Abstract: An intravenous (IV) tube organization apparatus includes at least one identification placard configured to couple to an IV tube. The identification placard includes a first tube capture portion configured to couple the identification placard to the IV tube, and a data portion to receive and display information regarding the IV tube. The IV tube organization apparatus also includes at least one arrangement clip configured to couple to the IV tube. The IV tube organization apparatus also includes a distinguishing characteristic to differentiate the apparatus from another apparatus.

Abstract: Provided in the present disclosure are a controller, a method for controlling controller, learning device, and a storage medium. Correct/incorrect determination of a transfusion tube is efficiently performed during a changeover. Motor shaft information of a driving motor, which drives an actuating portion sequentially compressing and relaxing a transfusion tube of a transfusion device, is obtained, and the correctness/incorrectness determination of the transfusion tube is performed on the basis of the motor shaft information.

Abstract: Implantable infusion devices and methods that provide closed loop control.

Abstract: Methods for treating a disease condition in a subject are provided. The subject methods are characterizing by enhancing at least one symptom of the disease condition in a manner effective to cause the subject to mount a compensatory response effective to treat the disease condition. Also provided are compositions, kits and systems for practicing the subject methods.

Abstract: An intravenous delivery system may have a liquid source containing a liquid, tubing, and an anti-run-dry membrane positioned such that the liquid, flowing form the liquid source to the tubing, passes through the anti-run-dry membrane. The anti-run-dry membrane may be positioned within an exterior wall of a drip unit, and may be secured to a seat of the exterior wall by an attachment component. The attachment component may have various forms, such as a secondary exterior wall that cooperates with the exterior wall to define a drip chamber, a washer positioned such that the anti-run-dry membrane is between the washer and the seat, and an adhesive ring formed of a pressure sensitive adhesive and secured to the anti-run-dry membrane and the seat via compression. Interference features may protrude inward from the exterior wall or outward from the anti-run-dry membrane to help keep the anti-run-dry membrane in place.

Abstract: The present disclosure includes systems, methods, and apparatuses for dispensing a volume (e.g., a volume of liquid or medication) during intraosseous infusion. In some embodiments, a resilient member is used to bias a portion of an arm towards a contracted position with a force sufficient to depress a plunger of a syringe, and a damper is used to resist movement of the portion of the arm from the extended position toward the contracted position to control a rate at which the resilient member can move the portion of the arm from the extended position toward the retracted position, and thereby limit the rate at which a volume is dispensed from the syringe. In other embodiments, a flow control valve may be used instead of a damper to limit the rate at which a volume is dispensed from the syringe.

Abstract: The embodiments described herein may relate to methods and systems for adjusting insulin delivery. Some methods and systems may be configured to adjust insulin delivery to personalize automated insulin delivery for a person with diabetes. Such personalization may include adjusting user specific dosage parameters in response to a user provided insulin delivery amount, including a user provided insulin delivery amount that varies from a recommended insulin delivery amount.

Abstract: An apparatus for filling a syringe with a verified dose of radiant fluid has a container holder that holds a container of the radiant fluid wherein a syringe oriented at a septum of the container can penetrate the septum. The syringe holder is configured to continuously grip the syringe, to drive the syringe to the container holder and penetrate the septum, to fill the syringe with a dose of the radiant fluid from the container, to drive the syringe to a transfer post, to drive the syringe to a metering zone of a metering station in order to verify that measured radiation is compatible with the dose, and to release the continuous grip.

Abstract: The present invention is directed to multi-liquid loading and delivery kits comprising a first storage vessel for a first active component, a second storage vessel for a second active component, at least two transfer syringes, at least two vial adaptors, at least two cannulas with a through lumen and a multi-liquid delivery device. The delivery device has dual hollow cartridges, each with at least one throughbore at one end and plunger access at the opposing end, a kick stand, a removable dual feed funnel, a spray or drip manifold and at least one spray or drip tip assembly.

Abstract: An apparatus and method are provided for opening auto-injectors for subsequent servicing and refilling with medicament. The apparatus opens and disassembles an auto- injector to gain access to its drug reservoir so that a replacement medicament may be applied. The apparatus provides for reassembling the auto-injector as a medical device for subsequent service.

Abstract: Apparatus for recording information concerning the use of an injection device, the apparatus comprising: one or more sensors for providing information indicative of how the injection device is used; a processor configured to analyse said information detected by the one or more sensors to determine use information, said use information corresponding to how the injection device is used; and a memory for storing said use information in an image format such that said use information can be retrieved from the memory and displayed in an image.

Abstract: A drug delivery device may include a housing having an opening and a drug storage container having a body portion with a proximal end and a distal end and a delivery member extending from the distal end of the body portion. The device may also include a plunger moveable toward the distal end of the drug storage container to expel a drug from the drug storage container through the delivery member and a plunger biasing member configured to urge the plunger toward the distal end of the drug storage container. The device may further include a container holder configured to support the drug storage container with respect to the housing such that a resultant force acting on the drug storage container from the plunger biasing member is at least substantially completely borne by the distal end of the body portion of the drug storage container.

Abstract: This application relates to force reduction in injection devices. According to a first aspect, the specification describes an injection device comprising: a medicament container; a stopper translatably disposed within the medicament container; a plunger rod, the plunger rod comprising a plunger head; a drive mechanism for displacing the plunger rod into the medicament container; and a force reduction feature, wherein the plunger rod is operable to displace the stopper; and wherein the force reduction feature is arranged to damp at least a part of a plunger rod motion when the plunger rod is driven by the drive mechanism.

Abstract: An assembly for a container to be filled with a pharmaceutical drug is provided. The assembly includes a first component and a second component. The first component has at least one electronic device fully embedded therein, a first end provided with a first engagement feature and an opposing second end. The second component has a second engagement feature configured to engage the first engagement feature of the first component.

Abstract: The present invention discloses a plunger rod (104) for use in connection with an injection syringe barrel (102). The plunger rod (104) comprises an elongated rod (114). The elongated rod (114) comprises a proximal end (107) adapted to receive an applied force along an axis (1000). It further comprises a distal end (105) adapted to transmit the applied force along the axis (1000). The plunger rod (104) is adapted to be inserted into a barrel (102) of a syringe (100) extending along the axis (1000). The plunger rod (104) is further adapted to transmit force along the axis (1000) to a plunger stopper (103) disposed within the barrel (102). The plunger rod (104) further comprises a radial spring mechanism (106, 117, 118, 119, 120), adapted to interact with an inner surface of the barrel (102).

Abstract: A medical plunger pump and a chamber structure thereof. The chamber structure includes a barrel, where the barrel is provided with at least one cylindrical chamber which includes a piston working section in which a piston is able to reciprocate and a joint section where the piston is connected to a push rod. The joint section includes a first arc section that protrudes from the piston working section, where a first end of the first arc section is smoothly connected to a side wall of the piston working section, and a second end of the first arc section is bent and extendable along an axis of the piston working section. The medical plunger pump includes the above-mentioned chamber structure.

Abstract: A medicine dispensing device including a vessel configured to contain a drug to be dispensed by the medicine dispensing device. The dispensing device includes a first series of zones of varying widths on a first portion of a surface of the vessel, with each zone of the first series of zones corresponding to a pre-determined treatment dose of the preselected drug, the treatment dose of the preselected drug correlated to a physical characteristic of a patient. A second series of zones of varying widths are also provided on a second portion of the surface of the vessel, with each zone of the second series of zones corresponding to a pre-determined prophylaxis dose of the preselected drug, the prophylaxis dose of the preselected drug correlated to the physical characteristic of the patient.

Abstract: Compact, light-weight, handheld printer devices are capable of delivering multi-part materials in mixed form, with controllable dwell-time within the device to allow for a desired amount of physical mixing and chemical cross-linking, while also allowing for deposition of the material directly onto a deposition site. A pen-style printer having a slim but elongated form factor is particularly suitable for depositing biomaterials directly onto a surgical site in the throat. The device may be configured to receive and dispense materials directly from conventional syringes. The printer device may be configured for dispensing and mixing materials having two or more component parts, and may include a leadscrew mechanism providing mechanical advantage, for dispensing higher-viscosity materials, and/or an enhanced degree of precision in dispensing a quantity of material. The mixing time and quantities can be controlled by varying one or more of syringe size and/or injector passage size and mixing chamber length.

Abstract: A system for mixing drug products and injecting includes a syringe body, proximal and distal stopper members disposed in the syringe body, a plunger member, and a needle hub assembly coupled to the distal needle interface of the syringe body. The proximal and distal stopper members form a proximal drug chamber between there between and a distal drug chamber between the distal stopper member and a distal end of the syringe body. The plunger member includes a needle retention feature, an energy-storage member, and an energy-storage member latching member all disposed in disposed in a plunger interior. First and second sizes of the respective proximal and distal drug chambers can be modified by movement of the proximal and distal stopper members relative to the syringe body. The needle is at least partially retractable into plunger interior upon manipulation of the plunger member relative to the syringe body.

Abstract: A Hypodermic Needle Safety Guard intended for sharps prevention and safer hypodermic needle use during all stages of an injection process. The Safety Guard may include two symmetrically positioned multi-featured arms that include spring tension, multiple hinges and needle locks. These arms may connect a proximal Luer body and a distal alignment tip thereby enabling the guard to open, close and lock on a needle when manual pressure is applied. The Guard position during hypodermic needle use tends to prevent sharps injury by adjusting the exposure of the Needle tip.

Abstract: A pen needle assembly includes an adapter (32, 122, 190, 254, 312) and a needle hub (134, 124, 192, 256, 314) coupled to the adapter. The needle hub is removable from the adapter. The adapter has a distal end for coupling with a pen needle delivery device and a distal end with at least one coupling member for coupling with the needle hub. The needle hub is a distal face forming a skin contact surface and a cannula extending from the distal face. The proximal end of the needle hub includes a coupling member for removably coupling with the coupling member of the adapter.

Abstract: A gaming system is provided, including a jackpot server and a gaming server. The jackpot server accumulates respective contributions from gaming client devices into a progressive jackpot. The gaming server presents wagering games to a player on a gaming client device. The wagering games include a first wagering game having a progressive jackpot component, and a second wagering game not having a progressive jackpot component. The gaming server receives a jackpot token from the player, including a token identification associated with the player and a progressive jackpot identification correlating to a token progressive jackpot. A wager is received for the second wagering game, which is conducted such that the player participates in the token progressive jackpot. The gaming server transmits a message to the jackpot server, including a portion of the wager as a contribution to the token progressive jackpot and an outcome of the second wagering game.

Abstract: The present disclosure relates generally to the field of medical devices. In particular, the present disclosure relates to devices, systems and methods for improved efficacy of radiotherapy treatment of hypoxic tumors. For example, the disclosed devices, systems and methods may statically or continuously oxygenate hypoxic tumors immediately prior to or simultaneous with irradiation.

Abstract: A dispenser including a reservoir configured for holding a fluid and more than one nozzle fluidly connected to the reservoir, wherein one of the more than one nozzle is a nozzle configured for dispensing one or more drops of the fluid and another one of the more than one nozzle is a nozzle configured for dispensing a spray, wherein the reservoir is configured to be squeezable to force the fluid to at least one of the more than one nozzle to be dispensed.

Abstract: Methods of making components for a medicinal delivery device are described, in which a base composition comprising a polysulphone is applied to the surface of a component to create a base layer, a primer composition comprising a silane having two or more reactive silane groups separated by an organic linker group is applied to the base layer to create primed surface, and a coating composition comprising an at least partially fluorinated compound is applied to the primed surface. Corresponding coated components and a medicinal delivery device are disclosed.

Abstract: An inhalation device including at least one processor configured to control an inhalation process including vaporing a substance received from a substance storage when coupled to the inhalation device, wherein the at least one processor is configured to be operated in an operation mode or in a standby mode, an electronic interface configured to be coupled to a substance storage interface, a passive detection circuit coupled between the electronic interface and the at least one processor and configured to detect whether the substance storage is coupled to the inhalation device (200), and, in case it is detected that the substance storage is coupled to the inhalation device, cause the at least one processor to switch from the standby mode to the operation mode.

Abstract: Disclosed is a system for respiratory system secretion management. The system comprises an oscillatory wave generator for generating a wave for loosening secretion from a respiratory system of a subject, a nasal module in communication with the oscillatory wave generator, for delivering the wave through a nasal passage of the subject, a power module configured to power the system, and a communication module coupled to at least one of the nasal module and the oscillatory wave generator. The communication module is for selectively communicating power and/or one or more waveform characteristics to the respective nasal module and/or oscillatory wave generator.

Abstract: The invention is related to a portable rebreathing system for closed rebreathing. In order to minimize consumption of oxygen during rebreathing mode while safeguarding correct oxygen concentration, oxygen is added into the breathing passage using staged addition of oxygen via at least three individual oxygen supply valves 51, 52, 53. The two first oxygen supply valves are calibrated nozzles where one nozzle 51 is constantly delivering a predetermined amount of oxygen during normal breathing and the second nozzle 52 adds more oxygen at a second predetermined amount when the person to be treated is breathing heavily. The third valve is only opened manually and delivers a short burst of oxygen that fills the rebreathing system and its counter lung within seconds.

Abstract: A display for outputting information contents of at least one parameter, adjustment value or measurement value of medical devices within at least one display region, wherein the at least one display region is in the form of a tachometer-like display.

Abstract: Systems, methods, and devices are disclosed for accurately detecting a position of an endotracheal tube by sensing patient anatomy surrounding the endotracheal tube. Systems of the present disclosure include an endotracheal tube having at least one sensor supported by the endotracheal tube configured to detect surrounding patient anatomy. A signal processing unit can receive data from the sensor and can at least one of (i) identify the detected patient anatomy, for example, vocal cords, (ii) determine a distance between the detected patient anatomy and a known point on the endotracheal tube, and (iii) verify a positioning of the endotracheal tube within a tracheal or esophageal lumen of the patient. In some embodiments, the system can include at least one inflatable component that can extend along an outer surface of the endotracheal tube and support the at least one sensor.

Abstract: The invention relates to a positioning sputum suction laryngeal mask. The positioning sputum suction laryngeal mask comprises a mask body and a mask body tube, wherein the mask body comprises a mask body bottom plate and a mask main body arranged on the mask body bottom plate, a central region in the mask main body is provided with a mask body cavity communicated with the mask body tube, a stomach decompression tube corresponding to the stomach mouth is arranged on the back side of the mask body bottom plate, and the stomach decompression tube is isolated from the mask body cavity through the mask body bottom plate. The positioning sputum suction laryngeal mask also comprises a connection suction mechanism capable of realizing negative pressure suction in a gas supply process.

Abstract: Novel airway devices and methods address complications of ventilating a patient with a mask; placing an endotracheal tube in an awake patient; and need for a bite block during flexible bronchoscopy and gastroscopy. The airway device features notches for engaging maxillary and mandibular teeth in a manner protracting the patient's mandible relative to the maxilla to open up the airway. This way, an open airway is easily maintained simply by holding the jaw closed against the device with the same hand used to operate a bag ventilator. A longitudinal channel in the device features a downwardly curved end wall for improved guidance of the endoscope into position. The channel is open sided at the top or bottom to allow rolling of the airway device off the endoscope into an offset position serving as a protective bite block and allowing feeding of the endotracheal tube along the endoscope.

Abstract: A ballooning patient interface has a frame that supports a sealing member. The frame and/or the sealing member is secured to the head of a user with headgear, such as a strap. Various features of the sealing member improve comfort for the user in the nares of the users as well as on facial surfaces in contact with the sealing member.

Abstract: A nitric oxide delivery system can include a cassette which is a single use disposable component used to store liquid N2O4 activate upon operator demand, convert N2O4 to NO2 via a heating element(s) controlled by a console to deliver NO2 at a controlled flow rate, direct concentrated NO2 to a contained pair of conversion cartridges and exhaust NO gas to the console for delivery to the patient.

Abstract: Provided is a sensory substitution apparatus and method that combines two or more pieces of multi-sense sensory information to be converted into different multi-sense sensory information, in which received pieces of multiple information are combined to suit sensory characteristics of the user's body and efficiently transmitted to a different sensory organ. According to the present invention includes: receiving input sensory information; classifying the input sensory information; calculating an importance of each of individual sensory information; determining a target sense for which part or all of the individual sensory information, of which an importance is calculated, is to be converted into a new sensory signal incongruent with the corresponding individual sense; and converting the input sensory information into target sensory information to be transmitted to the determined target sense which is an organ.

Abstract: A method is provided for measuring a wake up indicator, where the wake up indicator gives the likelihood of a user waking up undesirably. It is based on the knowledge that waking up during deep NREM sleep is not desirable due to sleep inertia and on the recognition that it is also undesirable to wake up during REM sleep due to atonia. A sleep inertia estimation is determined to estimate if the user is in NREM sleep and an atonia estimation is determined to estimate if the user is in REM sleep. The wake up indicator is determined from the sleep inertia estimation and the atonia estimation. The wake up indicator thus may be used as an indicator for the time when it is suitable to wake up the user in a way which avoids arousal from a deep sleep state or from REM sleep, during which atonia may arise.

Abstract: A method for streaming a bilateral alternating tactile stimulation (BLS) session on the Internet including operating a first processor at a first location to execute a program starting a therapeutic session linked to an Internet website. The therapeutic session is streamed through the Internet website. A second processor operates at a second location remotely located relatively to the first location to link to the therapeutic session. Video and/or audio are is transmitted from the first location to the second location through the Internet website. a series of BLS signals are transmitted from the first location. The series of BLS signals are synchronized with the transmission between the first location and the second location. Internet communications are transmitted and received from the second location through the Internet website. The synchronized BLS signals are received at the second location.

Abstract: Disclosed is a self-expanding cannula, systems using such cannulae, and methods of their use. The cannulae may comprise single lumen cannula (“SLC”) configurations and double lumen cannula (“DLC”) configurations, and include at least a first cannula and a self-expanding wire frame attached to the first cannula. Self-expanding wire frame is automatically expandable from a compressed state (providing a reduced cannula diameter as it is moved through a patient's body to the site at which it is to be deployed) to an expanded state (which increases the diameter of the cannula to the diameter intended for its normal use). The expanded wire frame provides radial support to prevent a drainage canal (whether a patient's blood vessel or a portion of the system inserted into the patient's blood vessel) from collapsing as fluid is drained from the patient.

Abstract: A vascular introducer is disclosed that includes a proximal housing defining an axial passageway, a body portion extending distally from the proximal housing and defining an axial bore in communication with the axial passageway of the proximal housing, and an elongated tubular sheath extending distally from the axial bore of the body portion and defining a central lumen, wherein the axial bore of the body portion and the central lumen of the tubular sheath are adapted and configured to transition between a first inner diameter and a second inner diameter in response to introduction of a dilator having an outer diameter that is greater than the first inner diameter of the axial bore of the body portion and the central lumen of the tubular sheath.

Abstract: Rapidly insertable central catheters (“RICC”) and methods thereof are disclosed. For example, a RICC can include a catheter tube, a suture wing disposed over a medial portion of the catheter tube, a hub coupled to a proximal-end portion of the catheter tube, and a number of extension legs extending from the hub. The catheter tube can include a first section in a distal portion of the catheter tube and a second section proximal of the first section. The second section of the catheter tube can include an outer layer extruded over an inner layer such that an outer diameter of the catheter tube is larger in the second section than the first section of the catheter tube. The catheter tube can have a column strength sufficient to prevent buckling when the catheter tube is inserted into an insertion site and advanced through vasculature of a patient.

Abstract: A medical device includes: a tube through which fluid flows; a handle part coupled to a proximal end part of the tube; an electrode tip coupled to a distal end part of the tube; a fluid injection part configured to inject fluid into the tube; one or more openings formed in the tube; and a guide member disposed in the tube, and having an inclined part to guide the direction of the fluid sprayed out through the opening.

Abstract: A steerable sheath includes an inner liner extending from a proximal to a distal end of the steerable sheath. The inner liner includes a non-deflectable portion and a deflectable portion. The steerable sheath includes a first pull wire positioned along a first helical path around the circumference of the inner liner from a proximal to a distal end of the non-deflectable portion and along a first straight path from a proximal to a distal end of the deflectable portion. The steerable sheath includes a second pull wire positioned along a second helical path around the circumference of the inner liner from the proximal to the distal end of the non-deflectable portion and along a second straight path from the proximal to the distal end of the deflectable portion. The steerable sheath may also include electrode wires present in a helical or spiral pattern around the circumference of the steerable sheath.

Abstract: Provided is an auxiliary tool that makes skin administration of a micro-needle array on which a large number of micro-needles are provided as a result of a progress in fine processing technology more certain. A skin tight-binding device provided with a tight-binding band, and a hole provided on the tight-binding band, in which, when the tight-binding band is fixed to skin, the hole forms a micro-needle patch administration portion, and the skin tight-binding device further provided with a fixing tool that fixes the tight-binding band to the skin.

Abstract: Embodiments of the present invention provide for a catheterization system and related methods. The systems and methods provide for the initial placement of a smaller diameter catheter within a patient, the catheter being expandable to a larger diameter by the implementation of a dilator, wherein the dilator is configured to contact and expand a lumen of the catheter as it is inserted therethrough.

Abstract: A guidewire includes a proximal guidewire portion and a distal guidewire portion. The proximal guidewire portion includes a proximal illumination fiber and a first connection portion. The distal guidewire portion includes at least one distal illumination fiber and a second connection portion. The first connection portion is configured to couple to the second connection portion to define a rotatable slip coupling. The distal guidewire portion is configured to rotate about the longitudinal axis relative to the proximal guidewire portion at the slip coupling. The slip coupling provides optical continuity between the proximal illumination fiber and the at least one distal illumination fiber. The slip coupling may include a rotation limiting feature configured to limit the rotation of the distal guidewire portion about the longitudinal axis relative to the proximal guidewire portion.

Abstract: Guidewire-management devices and methods thereof are disclosed herein. A guidewire-management device can include a guidewire, a first sleeve, and a second sleeve. The first sleeve can be configured for distally feeding the guidewire out of the guidewire-management device. The first sleeve can also be configured for proximally feeding the guidewire into the guidewire-management device. The second sleeve can be proximal of the first sleeve in the guidewire-management device. The second sleeve can be configured for feeding the guidewire in concert with the first sleeve. At least a length of the guidewire extending between the first sleeve and the second sleeve can be disposed within a sterile barrier configured to maintain sterility of the guidewire. Methods of the guidewire-management devices can include a method of using a guidewire-management device such as the foregoing guidewire-management device.

Abstract: Balloon catheters, methods for preparing balloon catheters, and uses of balloon catheters are disclosed. The balloon catheter includes an elongate member, an expandable balloon, and a coating layer overlying an exterior surface of the expandable balloon. The coating layer includes a total drug load of a hydrophobic therapeutic agent and a combination of additives including a first additive and a second additive. The hydrophobic therapeutic agent is paclitaxel, rapamycin, or paclitaxel and rapamycin. The first additive is a surfactant. The second additive is a chemical compound having one or more hydroxyl, amino, carbonyl, carboxyl, acid, amide, or ester groups.

Abstract: A catheter having a head with a head orifice and a head channel connected to the head orifice, a primary lumen wall that defines an internal primary lumen volume, an adjustable neck that connects the head channel to the internal primary lumen volume, an adjustment system partially enclosed in the primary lumen wall that provides an articulation of the adjustable neck between an extended position to a contracted positon, wherein the articulation from the extended position to the contracted position provides a flexible tip catheter while the articulation from the contracted position to the extended position provides an ability to angulate toward a target.

Abstract: Drug delivery devices having a drug-permeable component and methods of making and using the same are provided. Drug delivery devices include a housing having a first and second wall structures that are adjacent one another and together form a tube defining a drug reservoir lumen. The second wall structure, or both the first wall structure and the second wall structure, are permeable to water, and the first wall structure is impermeable to the drug while the second wall structure is permeable to the drug, such that the drug is releasable in vivo by diffusion through the second wall structure.

Abstract: A softgel capsule for controlled delivery of topical and oral products comprising, a substantially conical-shaped base and a top planar mouth end covered with a soft substrate with perforations to eject a measured quantity of a topical cream, lotion, gel, or other medicament on to a skin surface in a controlled manner without spattering, providing for a clean and mess-free application. The softgel capsule is also used to deliver a measured quantity of an oral medicament into the oral cavity in a controlled manner and the capsule itself is capable of being ingested after the dispersion of its contents into the oral cavity. The small size of the softgel capsule makes it easy to pack and transport when traveling.