Abstract: A method and (portable) device are provided for quantifying liver steatosis. The quantitative assessment of liver steatosis predicts whether a liver from the liver transplant donor is suitable for transplantation. Specifically, the quantitative assessment of liver steatosis predicts an associated risk for early allograft dysfunction. A biopsy image from a liver transplant donor is obtained from an automatic quantitative assessment of liver steatosis is made using a pre-trained artificial intelligence algorithm for identifying parameters of liver steatosis. The biopsy image is input to the pre-trained artificial intelligence algorithm. The quantitative assessment of liver steatosis is the output of the pre-trained artificial intelligence algorithm. Embodiments provide for rapidly diagnosing potential donor liver allografts at the time of procurement with a point-of-care device deployed with the transplant surgery team.

Abstract: An arrangement for determining external damage to hair is given. A device comprising: a reading unit adapted to obtain optical characteristics of hair; and a processing unit adapted to receive the optical characteristics from the reading unit and to determine surface properties of the hair from the optical characteristics, wherein the processing unit implements a pattern recognition algorithm and is adapted to assign, by employing the pattern recognition algorithm, the surface properties to a predetermined damage including at least one damage type and an associated damage level and to output the damage.

Abstract: There is provided herein a method for treating/diagnosing a speech/language related pathology, the method comprising: introducing a speech sample provided by a user to a speech/language machine learning (ML) classifier, wherein the ML classifier is trained with non-pathological/normal speech, applying novelty detection algorithms to compute a similarity measure, and based at least on the similarity measure, computing an output signal indicative of a speech/lingual quality of the user.

Abstract: A medical apparatus for estimating a mental/neurological disease with high precision is provided. This medical apparatus includes a computational processing device, a recording device having an estimation program which causes the computational processing device to execute processing recorded therein, a calculation unit configured to calculate a score of a subject, a detection unit configured to detect a disease whose score exceeds a reference range, and an estimation unit configured to estimate a mental/neurological disease.

Abstract: Disclosed is a method and an apparatus for detecting stages of sleep of a person. The method includes receiving temperature data and heart rate data of the person, and determining temperature variability on the basis of the temperature data and determining heart rate variability (HRV) on the basis of the heart rate data, and detecting stages of sleep of the person on the basis of the temperature variability and the heart rate variability.

Abstract: The present invention relates generally and specifically to combining biological sensors with external machines using machine learning to form computerized representations that can control effectors to deliver therapy or enhance performance.

Abstract: Embodiments of the present invention are directed to a two-layer adhesive and methods of using the same to secure an electronic device to an organism. In a non-limiting embodiment of the invention, a surface of the organism is coated with a first adhesive layer (bottom layer). The first adhesive layer is cured and a surface of the cured first adhesive layer is coated with a second adhesive layer (top layer). An electronic device is positioned on the second adhesive layer prior to curing the second adhesive layer. The second adhesive layer is then cured, thereby embedding the electronic device within the second adhesive layer. The bottom layer and the top layer are selected such that the bottom layer releases upon exposure to a first solvent after a first duration and the top layer releases upon exposure to a second solvent after a second duration more than the first duration.

Abstract: A microelectromechanical device and method for neuroprosthetics comprises microactuators and microelectrodes. The microelectrodes are to be positioned in a nerve bundle and bonded with the microactuators through an interconnect. The position of each of the microactuators can be individually tuned through control signals so that the microelectrodes are implanted at desired positions in the nerve bundle. The control signals are transmitted to the microactuators and generated with a open-loop or closed-loop control scheme that uses signals acquired by the microelectrodes from the nerve bundle as feedback.

Abstract: The present disclosure relates to various anchoring assemblies, systems, and methods for a catheter delivered device or otherwise implantable biomedical sensors. In one instance the anchoring systems of the present disclosure are designed to be used in connection with a biomedical sensor configured to be placed in the various locations within the anatomy of a patient including: a junction of a renal vein and an inferior vena cava, a junction of a jugular vein branch and a subclavian vein branch, a junction of a brachiocephalic vein branch and a superior vena cava, or a junction of an iliac vein branch and an inferior vena cava. In one embodiment, an biomedical sensor and anchoring system can be implanted in an organ of a patient or in an organ to be transplanted within a patient.

Abstract: The disclosure relates to a method for monitoring a motion of a subject, as well as to a corresponding system and computer program product. As part of the method, a monitoring signal is emitted towards a corresponding receiver. The motion of the subject is then detected based on a change in the received monitoring signal. Therein, the monitoring signal is emitted using a spread-spectrum technique and/or using an M-to-N and multi-antenna emitter-receiver system with a set of M transmitting antennas and a set of N receiving antennas.

Abstract: The present patent application aims to teach apparatus, methods, and systems for providing accurate imaging in an OCT-Fluorescence imaging system, all the while decreasing lengthy processing times for the imaging, thus leading to a more accurate and timely delivery of data and images to the end user.

Abstract: In certain embodiments, a headpiece 101 may contain the functional components described above integrated therein, and the headpiece may be releasably matable, The present invention relates to systems and methods for patient monitoring and intervention to prevent sudden unexpected death, as may occur in patients with epilepsy (SUDEP) or in infants as part of SUID, SIDS and/or suffocation. More specifically, the present invention provides a wearable device configured for monitoring a wearer and/or his environment, identifying and/or assessing death risk to the wearer, initiating communications to a caregiver that might provide an intervention or other treatment, and/or itself performing an action acting as an intervention to prevent death of the wearer. The wearable device includes particular sensors for gathering data from the wearer and/or the wearer's environment. Optionally, the wearable device may further include stimulators for delivering a death-preventing intervention stimulus to the wearer.

Abstract: The present disclosure provides systems and methods for medical imaging. The method may include obtaining a plurality of channels of electrocardiogram (ECG) signals of a heart of a subject; identifying, from the plurality of channels of ECG signals, a target channel of ECG signal, wherein an amplitude of a characteristic wave of the target channel of ECG signal is the maximum amplitude among amplitudes of corresponding characteristic waves of the plurality of channels of ECG signals; and causing, based on the target channel of ECG signal, an imaging device to perform a scan operation on the heart of the subject.

Abstract: Disclosed is a pendant device particularly used in emergency services of all hospitals, allowing health staff move more comfortably in resuscitation room, speeding up the procedure time of caring patient, providing more effective and faster production of patient reports, and a patient treatment reporting method achieved by use of the pendant device.

Abstract: A wearable device includes one or more sensors configured to generate data associated with one or more physiological characteristics of a user of the wearable device and one or more control circuits configured to obtain the data associated with the one or more physiological characteristics of the user and transmit the data to a remote computing device in response to detecting a proximity event associated with the wearable device and the remote computing device.

Abstract: A system for assisting an x-ray operator with properly positioning a patient's body part to be x-rayed. The system uses a range sensor and/or a camera supported on an x-ray emitter to collect data about the patient's body part to be x-rayed. The data is transmitted to a processor and compared to a selected reference envelope or image. The processor provides an x-ray operator with a positive or negative notification based on its analysis of the collected data and the selected reference envelope or image. A negative notification indicates that the patient's body part needs to be adjusted. A positive notification indicates that the patient's body part is ready to be x-rayed.

Abstract: The invention relates to a problem of setting mutual position of an anatomy being imaged and imaging means of a computed tomography imaging apparatus so that specifically the very volume of the anatomy desired to be imaged actually is imaged. To further the positioning, a positioning tool in a form of a three-dimensional virtual positioning model (40), generated from the anatomy to be imaged, is shown on a display from which the volume (41) of the anatomy desired to be imaged can be pointed, selected or defined.

Abstract: A device (10) for a patient to lie on during a medical imaging procedure includes a main body (12). A matrix of pressure sensors (16) disposed on a top surface (14) of the main body are configured to continuously measure pressure across the top surface. At least one electronic processor (22) is operatively connected to read the pressure sensors. A non-transitory storage medium stores instructions readable and executable by the at least one electronic processor to use the matrix of pressure sensors to perform at least one of: a sag estimation operation (200); a motion estimation operation (300); and a respiratory monitoring operation (400).

Abstract: A method for determining a deformation measurement of a couch in a medical procedure may include determining a first deformation measurement of the couch at a reference point, the first deformation measurement corresponding to a first working position of the couch. The method may also include determining a second deformation measurement of the couch at the reference point, the second deformation measurement corresponding to a second working position of the couch. The method may further include determining a difference between the first deformation measurement and the second deformation measurement and causing an adjustment of one of the first working position and the second working position of the couch based on the difference between the first deformation measurement and the second deformation measurement.

Abstract: The invention concerns an X-ray imaging apparatus for imaging a skull or a partial area of the skull, which apparatus comprises between the X-ray source and detector a patient support means (17). The patient support means (17) comprise a rear rest structure (170) containing a support part (171) arranged to get positioned at occipital area and a safety mechanism (173) in an area between its mounting point to the X-ray imaging apparatus (10) and said support pan (171). The safety mechanism (173) is arranged to go off when a force greater titan predetermined is acting on said support pan (171) and to release said support part (171) from its patient support position.

Abstract: An X-ray imaging apparatus according to an embodiment of the present disclosure includes an X-ray tube, a photon counting X-ray detector, and a filter unit. A generating unit of the X-ray tube is configured to generate X-rays. The photon counting X-ray detector is configured to count photons contained in the X-rays. The filter unit is provided between the X-ray tube and the photon counting X-ray detector. The filter unit includes a first filter and a second filter. The first filter is configured to shape a spectrum of the X-rays. The second filter is configured to generate X-ray fluorescence on the basis of X-rays related to a spectrum resulting from the shaping by the first filter.

Abstract: Various aspects include methods for use in X-ray detectors for adjusting count measurements from pixel detectors within a pixelated detector module to correct for the effects of pileup events that occur when more than one photon is absorbed in a pixel detector during a deadtime of the detector system. In various embodiments, count measurements may be obtained at two different X-ray tube currents, from which the detector system deadtime may be calculated based on the two count measurements and a ratio of the two X-ray tube currents. Using the calculated deadtime, a pileup correction factor may be determined appropriate for the behavior of the detector system in response to pileup events. The pileup correction factor may be applied to pixel detector count values after the counts have been corrected for pixel-to-pixel differences using a flat field correction.

Abstract: An imaging system comprises an adaptor plate configured to be removably coupled to a gantry structure of the imaging system, a plurality of detectors configured to be removably coupled to the adaptor plate, and one or more conduits for a fluid to flow through, wherein the fluid is used to cool the imaging system.

Abstract: X-ray devices and systems are described in this application. in particular, this application describes x-ray devices and systems that are used for three-dimensional (3D) image reconstruction with uncertain geometry. The x-ray imaging system contains an arm configured to be moved around an object to be imaged, a light weight, low power x-ray source attached to the arm, an x-ray detector configured to move complimentary to the x-ray source to capture multiple two-dimensional (2D) images in a solid angle path outside of a planar arc, 3D position and orientation tracking devices configured to capture the geometric position and orientation of the x-ray source and detector when each 2D projection image is captured, and a processor configured to construct a three dimensional (3D) image from the multiple 2D images using a reconstruction algorithm.

Abstract: In order to perform a setting of whether or not an input of an imaging failure reason at the time of an imaging failure is necessary, a check box 8j on whether or not the input of the imaging failure reason is necessary is displayed on a screen. When an operation to input a check mark in the check box 8j is performed, it is set that the input of the imaging failure reason is necessary. When an operation to remove the check mark from the check box 8j is performed, it is set that the input of the imaging failure reason is unnecessary. When it is set that the input of the imaging failure reason is necessary, a screen for inputting the imaging failure reason is displayed. When it is set that the input of the imaging failure reason is unnecessary, a screen for inputting the imaging failure reason is skipped. As a result, when the input of the imaging failure reason is unnecessary, the input operation is automatically skipped, reducing the burden on the operator.

Abstract: A method and a corresponding system are provided. The method comprises steps of providing 2D images and subsequently detecting outlines of a primary structure in each of the images. A visual representation of the 2D images is generated and the 2D images are then arranged as 2D slices in a 3D visual representation. To this end, at least two of the 2D images are taken at different imaging angles. The method provides a 3D visual representation of a region of interest comprising a primary structure to support a spatial sense of a user.

Abstract: In a method for recording a PET image data set, an overall recording area is moved continuously through the FOV at a constant movement speed, an attenuation map of the overall recording area being used to reconstruct the PET image data record from the PET raw data. The magnetic resonance data of a slice of the patient currently located within the FOV and movement status information relating to a cyclical movement of the patient are recorded simultaneously with recording the PET raw data. A movement status class is assigned to the PET raw data and the magnetic resonance data in each case. Using the magnetic resonance data assigned to the different movement status classes, attenuation maps of the patient are determined for the different movement status classes and applied to the PET raw data assigned to the corresponding movement status class to reconstruct the PET image data set.

Abstract: Systems and methods for quantification of an influence of scattered radiation in the analysis of an object a projection image is provided. Based on the projection image and on a characteristic of a tomography facility and/or of the object relating to the influence of the scattered radiation, at least one intermediate image is created. The at least one intermediate image is analyzed using an artificial neural network to quantify the influence of the scattered radiation.

Abstract: An on-board proton imaging system may include a continuous rotation gantry configured to generate proton beams during rotation thereof to penetrate a patient object, a beam detector arranged opposite of the gantry around the object and configured to receive residual proton beams having passed through the object, and a controller in communication with the gantry and a multilayer detector. The controller may be configured to instruct the gantry to generate the proton beams based on patient factors, receive data from the detector indicating at least an energy level of the residual beams, and generate a three-dimensional image based on the received data.

Abstract: The invention relates to a method for estimating a dose administered by a radiology system provided with an X-ray source and a flat surface sensor, wherein (a) an X-ray image of the patient is acquired by the flat surface sensor; (b) the grey level of the pixel is determined at the centre of the X-ray image; (c) the kerma K is calculated, on the patient's entrance from the grey level, from the electrical charge passing through the X-ray tube during the patient's exposure time, the thickness of the patient's body along the axis of the X-ray beam and the distance between the X-ray source and the patient. This method of estimating dose can significantly reduce the margin of error on the dose administered.

Abstract: The present disclosure directs to a system and method for controlling a radiation exposure on a subject. The method includes obtaining exposure instructions including an exposure state of an imaging device. The method also includes determining first components associated with the imaging device and one or more target operations of the first components corresponding to the exposure state. The method further includes generating target operation instructions based on the one or more target operations of the first components. The method still further includes controlling the first components to implement the target operation instructions.

Abstract: A method and system for determining a dose of modulation (DOM) profile are provided. The method may include obtaining a 3D image and a topogram image of the object. The method may further include obtaining a dose of modulation (DOM) profile generation model. The DOM profile generation model may be generated by training a preliminary model based on a plurality of sample CT images, a plurality of sample 3D images corresponding to the plurality of sample CT images, respectively, and a plurality of sample topogram images corresponding to the plurality of sample CT images, respectively. The method may further include executing the DOM profile generation model to generate a DOM profile related to a computed tomography (CT) scan of the object based on the 3D image and the topogram image of the object.

Abstract: A method for treatment of a vascular lesion. A biomarker insertion device introduces a biomarker into a vascular region. The biomarker binds to a lesion type of a plurality of lesion types. Under ultrasound imaging, an image brightness of an imaged biomarker differs based on the lesion type of the plurality of lesion types to which the biomarker binds. An ultrasound imaging probe of an ultrasound imaging system images the biomarker and produces an image brightness of the imaged biomarker. The lesion type is determined based on the image brightness of the imaged biomarker. A frequency of a high intensity focused ultrasound emission of a non-invasive high intensity focused ultrasound device is tuned based on the determined lesion type. The tuned frequency is applied to the vascular lesion, resulting in the destruction of the vascular lesion.

Abstract: A position monitoring system is provided that includes a tracheal tube having a distal portion with a radiopaque indicator. The tracheal tube is configured to be positioned within an airway of a patient. The position monitoring system also includes an external sensor configured to be positioned on an external surface of the patient. The external sensor includes an emitter configured to transmit energy into the patient and toward the distal portion and a detector configured to receive a reflected portion of the energy to permit identification of a position of the distal portion. The position monitoring system, in certain embodiments, further includes a video laryngoscope communicatively coupled to the external sensor. The video laryngoscope includes a display and a processor, and the processor is configured to instruct the display to present an indication of the position of the distal portion based on feedback from the detector.

Abstract: An ultrasound system is disclosed. Embodiments in accordance with the present invention include a transducer configured to acquire pulse-echo data at each transmit frequency bandwidth of interest. In addition, a bandpass filter is configured to receive a signal of the pulse-echo data, wherein the signal is bandpass-filtered over a plurality of frequencies. Further, a processor is configured to calculate a spatial coherence of the bandpass-filtered signal. The spatial coherence of the signal is calculated in a spatial domain or a frequency domain. The spatial coherence is used to predict target conspicuity. The processor selects a preferred frequency based on and, preferably, to realize, the target conspicuity.

Abstract: A system and method for automatically providing artifact warnings in Pulsed-Wave (PW) Doppler imaging is provided. The method includes acquiring, by an ultrasound system at a pulse repetition frequency (PRF), Pulsed-Wave (PW) Doppler signals from a selected gate position in a high PRF mode. The method includes determining, by a processor of the ultrasound system based on the PRF, a position of a virtual gate along a PW line in a B-mode image. The method includes presenting, at a display, the virtual gate at the determined position along the PW line in the B-mode image. The method includes analyzing, by the processor, B-mode image intensity values at the virtual gate in the B-mode image to determine whether the B-mode image intensity values exceed an intensity threshold. The method includes providing, by the at least one processor, a virtual gate warning when the B-mode image intensity values exceed the intensity threshold.

Abstract: Various methods and systems are provided for automatically or semi-automatically adjusting one or more ultrasound imaging parameters for imaging in a second mode based on images obtained in a first mode. In one example, a method includes operating an ultrasound imaging system in a first operating mode, determining an anatomy imaged by the ultrasound imaging system in the first operating mode, and responsive to an operating mode transition request, adjusting imaging parameters of the ultrasound imaging system in a second operating mode based on the first operating mode and the anatomy imaged in the first operating mode.

Abstract: A transducer assembly operable to transmit ultrasonic energy in a desired direction towards a zone adapted to be acoustically coupled to an object or area of interest is provided that has: a transducer layer; a backing layer disposed behind said transducer layer with respect to the desired direction; a back-matching layer disposed between the transducer layer and the backing layer to reflect towards said transducer layer part of the ultrasonic energy directed from the transducer layer to the backing layer; and a heat transfer layer disposed between the back-matching layer and the backing layer to drain heat from the transducer assembly. A process for manufacturing a transducer assembly is also disclosed.

Abstract: A syringe operable to rupture the amniotic sac and extract a pure, uncontaminated sample of amniotic fluid. The syringe includes a housing having an open insertion end opposite a handle end. The open insertion end includes a recessed portion with puncture member and fluid opening disposed therein. A plunger disposed within the tubular housing is operable draw the amniotic sac into the recessed portion of the syringe until it contacts the puncture member. The puncture member is operable to pierce the amniotic sac, and the plunger further provides a means for drawing a sample of amniotic fluid through the fluid opening and into the fluid receiving area within the syringe housing.

Abstract: A saliva collection and testing system comprising an electric toothbrush (1) suitable for taking a user's saliva by way of taking means (15), and a test unit (21) for testing the taken saliva, said test unit (21) including a seat (22) for the electric toothbrush (1) comprising means (25, 33) for taking the saliva collected by the toothbrush, said test unit (21) cleaning-up the saliva taking means (15) of the electric toothbrush (1) after saliva is taken so as to prepare said electric toothbrush (1) to a subsequent use. A digital tooth fingerprint sensor is present on the toothbrush and allows to recognize the user. Advantageously the test results are sent to a remote unit via a wireless system and in an encrypted mode for their subsequent processing by one or several Machine Learning algorithms which exploit an Artificial Intelligence.

Abstract: An articulated medical device having a hollow core, capable of large degrees of maneuverability through small spaces of a patient to reach a target with minimal invasiveness, and once the medical device has reached the target, allowing a medical tool to be guided through the hollow chamber for facilitating medical procedures, including endoscopes, cameras, and bendable medical devices, at the target.

Abstract: A biopsy device includes a body, a needle, a cutter, an analysis area, a valve, and a tissue sample holder. The cutter is movable relative to the needle and in communication with the needle for transporting tissue samples. The analysis area is disposed proximally of the cutter and in communication with the needle to receive a tissue sample cut by the cutter for analysis by a user. The valve is disposed proximally of the analysis area and configured to alternate between an open configuration and a closed configuration. The tissue sample holder is disposed proximally of the valve and fixedly attached to the body. The valve is configured to permit analysis of the sample disposed in the analysis area when the valve is in the closed configuration and to permit the tissue sample to be passed into the tissue sample holder when the valve is in the open configuration.

Abstract: A method of engaging a medical instrument with a medical instrument manipulator comprises receiving an indication that a first input coupling of the medical instrument is positioned adjacent to a first drive output of the manipulator. The first drive output is driven by a first actuating element. In response to receiving the indication, the first drive output is rotated in a first rotational direction. A determination is made, by one or more processors, as to whether a resistance torque is experienced by the first actuating element after rotating the first drive output in the first rotational direction. If the resistance torque is not experienced by the first actuating element after rotating of the first drive output in the first rotational direction, the first drive output is rotated in a second rotational direction.

Abstract: A mechanical locking assembly for an endovascular device, comprising a shaft comprising a main body a shaft comprising a main body and enlarged end, an inner channel component comprising a full collar formed on proximal end of the inner channel component, and an outer cage component comprising a partial collar formed on the outer cage component wherein the full collar of the inner channel component fully surrounds the outer cage component and the partial collar of the outer cage component at least partially surrounds the shaft.

Abstract: A medical device and method for closure of a puncture in a body lumen are disclosed. The device has an aggregate (10) of a support structure (20) and a substantially fluid tight patch member (30) attached thereto at an attachment unit (40). The aggregate has a first, temporary delivery shape, for delivery to an interior of said body lumen and to be subsequently subjected to a change of shape to a second shape, which is a tubular shape. When delivered in said body lumen, the patch member is arranged radially outside of said tubular support structure and arranged towards an inner tissue wall of the body lumen. The aggregate is the detached from a delivery device and said puncture is intraluminally closed in a leakage tight manner, advantageously supported by a physiological pressure of a body fluid in said body lumen. Rotational orientation is detectable by fiducial markers.

Abstract: A surgical stabilizer arm ends with a hybrid quick connect mechanism capable of holding tissue manipulator tools of either the ball type or the shaft type. The single integrated mechanism allows users to choose the type of attachment mechanism they prefer on a case-by-case basis. The mechanism has a spring-loaded sleeve that can be pulled back to enable an attachment (manipulator tool) to be inserted. A ball-style attachment is inserted through an opening in a grip cage, and a shaft-style attachment is inserted into an actuator (e.g., spring detent) through the claws of the grip cage. When the sleeve is released, a compression spring pushed the actuator forward, either pressing the ball attachment against the grip cage or pressing the spring detent against the shaft attachment to partially lock the attachment in place. Tightening a tension cable increases the pressure to fully lock the attachment in place.

Abstract: Disclosure herein are knotless suture anchor constructs and methods of use thereof. The suture anchor constructs can include a bone anchor and a suture. The bone anchor can include a suture anchoring member and can define a cavity and a longitudinal passage extending from a trailing end of the bone anchor at least partially therethrough to the cavity. The suture anchoring member can be located in the cavity. The suture can be coupled to the suture anchoring member and can include a tensioning portion, a repair portion, and an intermediate portion. The intermediate portion can form a suture loop extending along the longitudinal passage.

Abstract: An assembly includes a flexible fixation member, a suture, and a delivery device. The fixation member includes a body with two terminal ends. A suture passes through the flexible fixation member at various points along a length of the body such that portions of the fixation member are slidable relative to the suture and configurable to form a cluster within a surgical site. The delivery device includes a tubular member, an elongated inserter, and a trigger. The elongated inserter is slidably disposed within the tubular member. The inserter has a forked distal end configured to receive a portion of the flexible fixation member and the suture. The trigger is finger-engagable and fixedly coupled to the proximal end of the inserter. It is configured to advance and retract the inserter relative to the tubular member. The trigger includes a retention member for retaining a proximal end portion of the suture.

Abstract: Methods and devices are provided for anchoring suture to bone. In one exemplary embodiment, a suture anchor is provided that includes a proximal component, a distal component, and an intermediate component positioned between the distal component and the proximal component. The proximal and distal components can each be configured to move independent of one another and to move relative to the intermediate component. In this way, the proximal, intermediate, and distal components of the suture anchor can be configured to cooperate with one another to prevent removal of the suture anchor from a bone hole in which the suture anchor is disposed and to lock a suture relative to the suture anchor and to the bone hole.

Abstract: A suture anchor and methods of use thereof are disclosed. The suture anchor comprises an anchor body having a slot formed in the body and a passage extending through the body in a first direction. The passage is sized to permit a suture to traverse the body through the passage. The suture anchor also has a shaft with a sharp portion, and the slot and the passage intersect within the anchor body. The shaft is movable relative to the anchor body within the slot from a first position in which the sharp portion and the passage do not intersect, to a second position in which the sharp portion and the passage intersect. The shaft can penetrate a suture or multiple suture strands to fix the suture or suture strands relative to the suture anchor.