Abstract: A medication adherence system for facilitating adherence to a medication dosage schedule is provided, comprising a smart case to receive or adhere to a medication pack, a sensor for detecting a medication event, and a tangible computer readable medium interface for users to obtain feedback regarding their adherence to their respective medication dosage schedules.

Abstract: According to the invention, gene products expressed in a tumor-associated manner and the nucleic acids coding therefor were identified. The invention relates to the therapy and diagnosis of diseases wherein said gene products expressed in a tumor-associated manner are aberrantly expressed. The invention also relates to proteins, polypeptides and peptides which are expressed in a tumor associated manner and to nucleic acids coding therefor.

Abstract: The present invention provides a dental adhesive composition that, even after photocuring with a high-output LED irradiator, shows high bond strength not only for dentin untreated by phosphoric acid etching but also for dentin treated by phosphoric acid etching. The present invention relates to a dental adhesive composition comprising a phosphoric acid group-containing polymerizable monomer (A), the phosphoric acid group-containing polymerizable monomer (A) comprising: a dihydrogen phosphate monoester group-containing polymerizable monomer (A-1) represented by general formula (1); a hydrogen phosphate diester group-containing polymerizable monomer (A-2) represented by general formula (2); and a phosphoric acid tetraester group-containing polymerizable monomer (A-3) represented by general formula (3).

Abstract: Masking compositions useful for dental restoration, particularly masking compositions used as a coating to mask the unnatural color of milled lithium-silicate glass-ceramic dental restorations in soft states before crystallization cycle, and method of making same. Some embodiments relate to masking compositions comprising at least one glaze powder, at least one opacifier, and at least one colorant. Some embodiments relate to coating, drying, cooling, characterizing, and firing of dental restorations.

Abstract: A passenger cabin monitoring system includes infrared cameras disposed in respective passenger rest compartments, a flight attendant information system including at least one display and at least one speaker, and a computing device in communication with the infrared cameras and the flight attendant, information system. The computing device is configured to detect a temperature of a portion of passenger rest compartment based on one or more thermal images generated by a respective infrared camera of the passenger rest compartment. The computing device is further configured to compare the temperature of the portion of the passenger rest compartment with a predetermined critical temperature and provide an audible alert and/or a visual alert via the flight attendant information system to indicate a critical status of the passenger rest compartment when the temperature of the portion of the passenger rest compartment is above the predetermined critical temperature.

Abstract: A wearable article, a moisturizing composition and a method for preparing a wearable article have been disclosed. The wearable article includes at least a layer of a flexible material, wherein the flexible material is an elastomeric material and an inner surface of the layer of flexible material is a coated with a coating formulation comprising 1% to 7% by weight of a moisturizing composition and 93% to 99% by weight of solvent. The moisturizing composition includes 10 to 30% by weight of at least one humectant and 1.0 to 5.4% by weight of at least one antioxidant. Thereby, the present invention reduces transepidermal water loss (TEWL) and promotes skin barrier recovery.

Abstract: A tablet-type cosmetic with improved handling properties is characterized by comprising (A) 30-91% by mass of trehalose and (B) 4.0-16% by mass of polyethylene glycol with a molecular weight of 11,000-25,000, and having a bulk specific gravity of 0.1-0.5 g/ml.

Abstract: Provided is a cosmetic product with superb aesthetics having functionalities of a plurality of cosmetic materials with different forms in a single cosmetic product. Cosmetic product 1 of the present invention is completed by first loading a container 2 with a gel-like, cream-like or semisolid formulation A, and then loading a gel-like, cream-like or semisolid formulation B with a different composition inside the loaded formulation A. The present invention can provide cosmetic product 1 having a shape wherein the formulation B with a different functionality is surrounded in a spherical shape inside the formulation A having another functionality, the cosmetic product 1 having both superb aesthetics and functionalities.

Abstract: A purpose of the present invention is to provide an oil-in-water emulsion composition that is stable even when using solid oils from which it was conventionally considered to be difficult to form large oil-based particles exceeding 50 ?m, and also improving the uniformity of the particle sizes and the shapes of the oil-based particles. The present invention relates to an oil-in-water emulsion composition in which oil-based particles containing a solid oil, a liquid oil and a powder are dispersed in a water phase, wherein: the oil-based particles have an average particle size of 50 ?m to 10 mm; and the powder is contained inside the oil-based particles.

Abstract: The present invention relates to a water-in-oil cosmetic composition with excellent fluidity and stability, comprising a large amount of aqueous phase. The water-in-oil cosmetic composition of the present invention has excellent filling property, stability at high temperature and long term stability, by forming a desirable fluidity in the process of preparation at high temperature. Preferably, the water-in-oil cosmetic composition of the present invention may excellently exhibit a water-drop effect due to high content of aqueous phase.

Abstract: This patent document discloses a kit containing abase component and an activating component for cosmetics, therapeutic and aesthetic application purposes. The kit, comprised innovative technology, ingredients, and formulations that overcome the drawbacks of unviable, unpractical, unwearable and unmarketable products, enables a film-formed “young-looking skin” to cling onto the real skin for much longer period of time, and is truly wearable and viable to the consumers for achieving the benefits of dramatically reducing or diminishing eye bags, dark circles, enlarged pores, wrinkles, age spots, and so on with desired and rapid results. The film is comfortable, invisible, safe, non-invasive and easy to wear.

Abstract: An aqueous oral care one-part composition (e.g., solution), a kit that includes such composition (e.g., solution), and methods (e.g., a method of providing fluoride to a patient's tooth surface), wherein the oral care composition (e.g., solution) includes: silver cations; iodide anions; fluoride anions; and water.

Abstract: The present invention relates to a pigment mixture based on at least two components A and B, where component A is a mixture of flake-form and spherical substrates which is covered with one or more inorganic layers and/or organic layers, and component B comprises crystalline or amorphous particles selected from the group of the metal oxides, metal hydroxides, metal oxy-halides, Prussian Blue or mixtures thereof, and to the use thereof in paints, coatings, printing inks, security printing inks, plastics, ceramic materials, glasses, in cosmetic formulations, as tracer, as filler and for the preparation of pigment preparations and dry preparations.

Abstract: Provided is a white pigment for cosmetics, and the white pigment has a higher function as a base pigment than that of titanium oxide. A white pigment for cosmetics of the present invention includes a titanium phosphate powder having a whiteness of 92.91 or more as determined in accordance with JIS Z 8715.

Abstract: The present invention is directed to a hair growth agent for external use comprising chiro-inositol, which is provided as an excellent hair growth agent.

Abstract: Compositions, such as personal care compositions, and methods for selectively inhibiting the growth of a detrimental bacteria and promoting the growth of a beneficial bacteria are disclosed. The composition may include a base and one or more fatty alcohols. The one or more fatty alcohols may be present in an amount effective to selectively inhibit the growth of at least one detrimental Gram-positive bacteria and promote the growth of at least one beneficial Gram-positive bacteria on skin. The detrimental Gram-positive bacteria may include Corynebacterium, and the beneficial Gram-positive bacteria may include Staphylococcus.

Abstract: Described herein is a stable perfuming composition including a perfume oil, a viscosifying agent including tricyclodecanedimethanol alcohol, and a perfumery carrier including hexylene glycol. Also described herein is the use of hexylene glycol in a composition including tricyclodecanedimethanol alcohol and a perfume oil to prevent the crystallization of the composition.

Abstract: The present invention is directed a shampoo composition for hair frizz reduction comprising from about 0.1% to about 20% of a moisture control material or mixture of moisture control materials wherein the moisture control material is selected from one or more of the following: Class II having the structure selected from: a) wherein R is hydrogen or metal ion, R6 is methyl, ethyl, propyl, alkenyl or phenyl having less than 12 carbon atoms and wherein R7, R8, R9, R10, R11, R12 are hydrogen, methyl, ethyl, propyl, phenyl, hydroxyl, methoxy or ethoxy groups; b) an alcohol wherein R13 is an alkyl, alkenyl, straight or branched carbon chains and; and wherein R14 is hydrogen, hydroxyl, alkyl, methyl, ethyl and propyl wherein the structure of such alcohol contains less than 20 total carbon atoms; c) alcohol comprising an unsaturated double bond in the C2 position.

Abstract: Disclosed is a topical skin composition comprising a glycol di-salicylate or a glycol di-benzoate compound having the following structure: where R is OH or H, n is 1 or 2, and where the composition further includes a glycol mono-salicylate compound or a glycol mono-benzoate compound.

Abstract: Disclosed are hair-colouring compositions comprising an oxidative dye and an alkalising agent consisting of isopropanolamine and a malic acid diester. The compositions according to the invention, due to synergic effects between isopropanolamine and the malic acid diester, are advantageous, because they lighten the hair by up to four levels, do not have an unpleasant odour, and limit the damage caused to the hair, maintaining its integrity and consequently its natural characteristics of elasticity, shine and combability.

Abstract: Described herein are rinse-off hair conditioner compositions with high deposition properties for cationically coated microcapsules. The compositions contain limited amounts of quaternary ammonium salts that are replaced by at least one non-quaternized conditioning ingredient to provide a high deposition of microcapsules onto a surface.

Abstract: The present invention relates to a cleansing composition which can simultaneously provide excellent washing performance and a good care feeling while securing good stability without being influenced by the use environment which may variously vary. The cleansing composition includes the following components (A) to (C): (A) an internal olefin sulfonate having 12 or more and 24 or less of carbon atoms: 1.8 mass % or more and 20 mass % or less; (B) a cationic surfactant represented by a specific formula: 0.1 mass % or more and 8 mass % or less; and (C) an aliphatic alcohol having 12 or more and 22 or less of carbon atoms: 1 mass % or more and 20 mass % or less, wherein a mass ratio of the content of the component (B) to the content of the component (A), (B)/(A), is 0.1 or more and 1 or less, and a mass ratio of the content of the component (C) to the total content of the component (A) and the component (B), (C)/{(A)+(B)}, is 0.1 or more and 4.5 or less.

Abstract: The present invention relates to a novel compound represented by following formula 2 produced by means of marine-derived fungus Penicillium sp. and a composition for improving skin wrinkles, enhancing elasticity and skin whitening using excellent collagen synthesis promoting activity and melanin production inhibitory activity of the novel compound. In formula 2, R1 is any one selected from the group consisting of H, OH, COOH, an alkyl having 1 to 6 carbon atoms and an alkoxy having 1 to 6 carbon atoms. R1 is any one selected from the group consisting of H, OH, COOH, an alkyl having 1 to 6 carbon atoms and an alkoxy having 1 to 6 carbon atoms. R2 is any one selected from the group consisting of H, OH, COOH, an alkyl having 1 to 6 carbon atoms and an alkoxy having 1 to 6 carbon atoms. R3 is any one selected from the group consisting of H, OH, COOH, an alkyl having 1 to 6 carbon atoms and an alkoxy having 1 to 6 carbon atoms.

Abstract: Active substance combinations of N-(4-amino-2-methylquinoline-6-yl)-2-((4-ethylphenoxy)methyl)benzamide and one or more cosmetically or dermatologically acceptable fragrances.

Abstract: Use of N-(4-amino-2-methylquinoline-6-yl)-2-((4-ethylphenoxy)methypbenzamide for producing cosmetic or dermatological preparations for the treatment and/or prophylaxis of symptoms of intrinsic and/or extrinsic skin aging and for the treatment and/or prophylaxis of damaging effects of ultraviolet radiation on the skin.

Abstract: A hair coloring composition that includes about 5 to 25 wt. % of a first monosaccharide having 2 to 4 carbon atoms, up to about 10 wt. % of a second monosaccharide having 2 to 4 carbon atoms, about 0.1 to 5 wt. % of a surfactant, and about 0.1 to 5 wt. % of a delivery agent, each based on a total weight of the hair coloring composition. A method for coloring hair, that involves applying the hair coloring composition onto the hair, and optionally applying heat to the hair at a dyeing temperature of 30 to 205° C.

Abstract: The invention relates to i) a process for treating keratin fibres, in particular human keratin fibres such as the hair, employing a) at least one oxidized polysaccharide, in particular oxidized inulin, and b) at least one (polysaccharide with amine group(s); ii) a composition comprising the ingredients a) and b); iii) the use of a) and b) to treat keratin fibres, in particular human keratin fibres such as the hair, and iv) a multi-compartment kit or device comprising a) and b). The invention makes it possible to obtain good hair-conditioning cosmetic properties, with a long-lasting effect.

Abstract: The instant disclosure generally relates to a bicomponent composition for coloring mammalian or synthetic keratin fibers, the bicomponent composition comprising first, second, components. The first component includes an organic polymer, the second component includes a pretreatment base compound. One or more of the components includes pigment microparticles. The bicomponent composition combines upon application to treated material such as hair, forms a solid coating thereon and has a substantially long color fastness following development (setting). Methods of using such compositions are also described herein.

Abstract: Storage stable organopolysiloxane gels, preparable in commercial quantities are prepared by the hydrosilylation reaction of a silicone resin containing a hydrosilyatable group, a short chain Si—H-functional silicone, and a long chain Si—H-functional silicone.

Abstract: A composition derived from seawater enriched in magnesium and depleted in potassium, the method for preparing the composition and its use as a moisturising and/or soothing cosmetic agent. A cosmetic composition includes the composition derived from seawater and a cosmetic treatment method includes the topical application of the composition.

Abstract: Various compositions and methods for treating or preventing damage to hair, especially in over-processed or chemically treated hair, are described.

Abstract: An oral disintegrating tablet (ODT) comprising an active ingredient, about 1 to about 20% w/w of at least one amphiphilic compound, about 1 to about 60% w/w of at least one disintegrant and about 0.5 to about 5% w/w of at least one binder, wherein the ODT has hardness of at least about 1 kp and wherein, when the ODT contacts a hydrophilic solvent, the amphiphilic compound self-assembles into liquid crystalline particles.

Abstract: A method of administering diazepam with a multimodal delivery profile is described.

Abstract: A topical mixture that produces nitric oxide and a method for using the topical mixture to increase the vasodilation of a bloodstream via transdermal absorption of the nitric oxide. The nitric oxide can then affect subcutaneous tissues. The systemic vasodilation of a mammal may be increased via a topical application of an appropriate nitric oxide producing substance.

Abstract: The invention relates to a combination drug with increased storage stability containing chondroitin sulfate (4.5 mg/ml), hyaluronic acid (16 mg/ml), a phosphate buffer (pH 6.1 to 7.9) and an electrolyte (e.g., an alkali salt, e.g., sodium chloride) for the treatment inflammations of the urogenital tract, in particular of the bladder, in particular for the treating cystitis, and to an instillation kit containing said drug.

Abstract: Hot melt extrusion is disclosed as a process for forming vaginal drug delivery films. The methods involve extruding a composition comprising one or more active pharmaceutical ingredients and one or more polymer carriers at an elevated temperature through a die to thereby provide the film. Films prepared by hot melt extrusion are also described.

Abstract: A non-irritation, non-blurring, photostable ophthalmic sunscreen composition contains at least one of the following: bemotrizinol; bisoctrizole; tris-biphenyl triazine; and/or octyl methoxycinnamate. A liquid vehicle base is then a remainder of the solution by weight. The composition is an artificial tear formulation or an ophthalmic suspension or ointment. The composition may include at least one inorganic and/or at least one organic active ingredient. The inorganic active ingredients may include, but not be limited to zinc oxide, titanium dioxide, iron oxide, zirconium oxide, and cerium oxide. The organic active ingredients may include, but not be limited to dioxybenzone, octinoxate, octisalate, homosalate, avobenzone, octocrylene, para-aminobenzoic acid, cinoxate, methyl anthranilate, octocrylene, padimate O, ensulizole, sulisobenzone, trolamine salicylate, and ecamsule.

Abstract: In one aspect, the disclosure relates to relates to compositions, devices, and processes for drug delivery to an eye. The disclosed drug delivery compositions comprise a particle having a core component comprising a first polymer and a therapeutic agent, and a shell layer surrounding the core component comprising a second polymer. In a further aspect, the present disclosure relates to methods of treating an ophthalmological disease or disorder. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: An oral disintegrating tablet that forms liquid crystalline particles or liquid crystalline bulk phase upon disintegration. The oral disintegrating tablet is fast disintegrating following contact with saliva and/or the oral mucosa but also provides slowed delivery of the active ingredient to avoid the difficulties associated with the speed of delivery of an active ingredient through the oral mucosa.

Abstract: A chewable supplement made by providing gelatin; providing an optional emulsifier; providing a food-grade oil; mixing the gelatin, and the emulsifier with the food-grade oil with to achieve a first mixture; heating the first mixture to achieve a heated first mixture; removing heat from the first mixture; providing collagen; adding the collagen to the first mixture and mixing the collagen with the first mixture to achieve a collagen mixture; and separating the collagen mixture into individual doses.

Abstract: The invention relates to dry powder formulations comprising respirable dry particles that contain 1) itraconazole in crystalline particulate form, 2) polysorbate 80, and 3) one or more excipients, wherein the ratio of itraconazole to polysorbate 80 (wt:wt) in the feedstock solution is greater than 10:1.

Abstract: Provided is a liposomal sustained-release composition for use in treatment of pulmonary disease. The liposomal sustained release composition comprises a liposome that includes a polyethylene glycol (PEG)-modified lipid and encapsulates a tyrosine kinase inhibitor. Tyrosine kinase inhibitor is stably entrapped in the liposome, and the resulting liposomal drug formulation can be aerosolized or nebulized for administration via inhalation. This aerosolized liposomal drug formulation yields consistent pharmacokinetic and pharmacodynamic profiles while achieving desired efficacy and safety.

Abstract: Methods of prophylactically treating fibrotic conditions using a synthetic lamellar body composition are provided, such as conditions of the lung, skin, gastrointestinal system, genitourinary system, heart, peritoneum, kidney, liver, and mucosa. In particular the present invention is concerned with lung injury which may be characterised by increased pulmonary vascular permeability. Suitably the lamellar body composition for use in the prophylactic treatment of fibrotic or pro-fibrotic conditions comprises phosphatidylcholine, cholesterol and optionally at least one phospholipid selected from phosphatidyl serine, phosphatidyl glycerol and phosphatidyl inositol to provide an anionic lamellar body.

Abstract: Provided herein is a pharmaceutical composition for treating cancers. The pharmaceutical composition includes an oil-in-water (o/w) microemulsion, and an active pharmaceutical ingredient dissolved therein. The o/w microemulsion is comprised of an aqueous solution, an oil, and a surfactant, and is about 5-250 nm in diameter. Also provided herein are methods for treating cancers by use of the present pharmaceutical composition.

Abstract: The present invention relates to a self-emulsifiable composition including a monoacyl phospholipid, a diacyl phospholipid, oils and fats, and a polyhydric alcohol, in which the content ratio between the monoacyl phospholipid and the diacyl phospholipid is in the range of monoacyl phospholipid:diacyl phospholipid=1:9 to 9:1 as a mass ratio.

Abstract: The present invention provides methods of treating arthritis. A sustained release composition comprising liposomes and one or more therapeutic agent or a pharmaceutically acceptable salt thereof is administered to a subject in need thereof. The liposomes may be in an aqueous suspension. The sustained release composition can be administered intraarticularly.

Abstract: Compositions and methods relating to modulating thermogenic regulation are disclosed. The compositions and methods can be used to treat diseases or conditions such as obesity or cardiometabolic disorders such as type 2 diabetes mellitus, NAFLD and NASH. Compositions include an adipocyte-targeting composition that includes a therapeutic agent capable of modulating thermogenic regulation, a targeting element facilitating cellular uptake and delivery of the therapeutic agent to a targeted adipocyte, and liposomal particles comprising sphingomyelin, DMPC, and cholesterol, wherein the liposomal particles enhance intra-cellular penetration of the therapeutic agent and protect the therapeutic agent from degradation.

Abstract: This application is directed to methods which allow for encapsulation of an array of biological materials under physiological conditions that are relevant given a biological context and the compositions made using those methods. These reconstituted biological materials encompass: a) purified proteins that can bind to the lipid membranes inside and outside of vesicles based on the electrostatic charge; b) purified cytosolic proteins that position themselves in the lumen of the vesicles, c) mammalian cell extracts with an array of cytosolic protein content, among other contents and d) small biological molecules such as DNA and RNA as well as fluorescent dyes/probes. These vesicles can be used to simulate cells in drug discovery methods as well as useful in administering drugs and other compositions to cells in vitro and in vivo.

Abstract: A cerasome delivery system for targeting activated cd44 molecule, a preparation method and use thereof: a surface of a cerasome is partially modified by a targeting ligand, the targeting ligand being a ligand which may specifically bind to an activated cd44 molecule. The cerasome delivery system may be used for the diagnosis, prevention and treatment of vulnerable plaque or diseases associated with vulnerable plaque.

Abstract: The disclosure relates to a processing system for in particular pharmaceutical powders, and to a method for decontamination of such a processing system. The processing system includes a processing device for the powder, and a closed housing with an inner production space in which the processing device is arranged. The processing system further includes a steam generator via which water vapor is introduced into the production space in such a quantity that air supersaturated with water vapor develops there at least in some parts. Any powder residues present are bound via water since, on account of the supersaturation, water condenses in the production space. The condensed water, including powder residues bound therein, is removed, in particular with the housing opened.