Abstract: This medical device (2) comprises a pre-filled syringe (3) comprising a syringe body (4) and a piston (16) mounted sliding in the syringe body (4), the syringe body (4) and the piston (16) delimiting an internal chamber (17) containing a fluid to be administered; and a package (21) in which the pre-filled syringe (3) is arranged, the package (21) comprising first and second package portions (22, 23) mounted movable relative to each other between a storage configuration in which the first and second package portions (22, 23) prevent the pre-filled syringe (4) from being removed from the package (21), and an open configuration in which the first and second package portions (22, 23) allow the pre-filled syringe (3) to be removed from the package (21), a movement of the first and second package portions (22, 23) from the storage configuration to the open configuration causing the piston (16) to move from a first piston position to a second piston position.

Abstract: A packaging for a reel of medical injection devices includes a base tray configured for supporting the reel and at least a first flat rib and a second flat rib. Each rib includes a respective slot arranged such that the ribs can be interlocked with one another by mutual engagement of the slots. The base tray includes at least two pairs of peripheral openings. Each opening is configured to receive an end of the ribs, so that the base tray and interlocked flat ribs engaging the base tray form a frame configured for enclosing the reel.

Abstract: Double-lumen infusion catheter including: a shaft having proximal section, distal section, and intermediate section therebetween; first and second lumens extending along a length of the shaft and having arc shaped wall therebetween; and an inflatable member provided distally to intermediate section, and over the distal section. First lumen has cross section larger than cross section of second lumen and is configured to receive a guidewire therethrough and allow fluid flow via an unobstructed portion of first lumen. Unobstructed portion is formed along guidewire outer surface, between guidewire outer surface and inner wall of first lumen, and extends from an inlet at proximal end of intermediate section to an outlet at distal end of intermediate section. First lumen is narrowed to approximate a first diameter in shaft proximal and distal sections, and is widened to approximate a second diameter greater than first diameter in the shaft intermediate section.

Abstract: Provided is a flexible and conformal wearable, self-contained medical device. The medical device comprises an integral housing formed by a flexible upper portion and a flexible lower portion joined along their perimeters. The medical device is also provided in a plurality of shapes and configurations for increasing the flexibility and conformability of the housing. The components contained within the housing, such as a drug reservoir, printed circuit board, and power supply are preferably constructed from flexible materials and are formed, connected and positioned according to the configuration of the housing in a manner for enhancing flexibility of the housing. A thermal bubble micropump is provided for controlling flow of a drug from the flexible reservoir, that utilizes a thermal resistor provided locally to a thermal expansion fluid that causes a surrounding membrane to expand and displace a volume of drug to be provided to the user.

Abstract: Provided is a wearable, self-contained drug infusion or medical device capable of communicating with a host controller or other external devices via a personal area network (PAN). The medical device utilizes a PAN transceiver for communication with other devices in contact with a user's body, such as a physiological sensor or host controller, by propagating a current across the user's body via capacitive coupling. The wearable nature of the medical device and the low power requirements of the PAN communication system enable the medical device to utilize alternative energy harvesting techniques for powering the device. The medical device preferably utilizes thermal, kinetic and other energy harvesting techniques for capturing energy from the user and the environment during normal use of the medical device. A system power distribution unit is provided for managing the harvested energy and selectively supplying power to the medical device during system operation.

Abstract: A syringe pump according to an embodiment includes a lead screw and a slider. The slider has an engagement part that engages with the lead screw and a slider cover with an internal space that houses the engagement part and is formed therein and an external surface that contacts a plunger of a syringe, and slides to move in a predetermined direction of travel with rotation of the lead screw to push the plunger. Then, the slider cover has a contact part that is provided in the internal space and contacts, when the slider pushes the plunger, a location that is close to the engagement part where the location is provided on a side of the direction of travel.

Abstract: This disclosure teaches a disposable inserter which includes a housing having arranged in a displaceable configuration an inserter assembly comprising a cannula assembly with a cannula, a manually operable member for displacing the inserter assembly from a retracted position to an advanced position in order to manually insert the cannula into the skin of a patient, a locking element for blocking or enabling displacement of the inserter assembly, and a coupling arrangement for coupling the disposable inserter to a reusable inserter for automatically displacing the inserter assembly from the retracted position to the advanced position in order to automatically insert the cannula into the skin of the patient.

Abstract: A system and method for monitoring and delivering medication to a patient. The system includes a controller that has a control algorithm and a closed loop control that monitors the control algorithm. A sensor is in communication with the controller and monitors a medical condition. A rule based application in the controller receives data from the sensor and the closed loop control and compares the data to predetermined medical information to determine the risk of automation of therapy to the patient. A system monitor is also in communication with the controller to monitor system, remote system, and network activity and conditions. The controller then provides a predetermined risk threshold where below the predetermined risk threshold automated closed loop medication therapy is provided. If the predetermined risk threshold is met or exceeded, automated therapy adjustments may not occur and user/clinician intervention is requested.

Abstract: An injection device for delivering equal doses of a fluid contained in a reservoir, the device having a housing, and an arming mechanism and a dose delivery mechanism arranged therein, the housing coupled to an enclosure for the reservoir. The arming mechanism includes an axially non-displaceable and rotatable setting sleeve. The setting sleeve is coupled with a spring strained by the rotation of the setting sleeve during arming of the device. The dose delivery mechanism includes a screw ring and a non-rotatable and axially displaceable piston rod within the setting sleeve. The piston rod cooperates with the screw ring so that during arming, the screw ring and the piston rod are immobilized, and during delivery of each dose the piston rod is displaced along the housing due to unwinding of the spring and rotation of the screw ring, the displacement of the piston rod causing the fluid to be discharged from the reservoir.

Abstract: The invention provides methods and apparatus for injecting a medicine, especially a highly viscous medicine. Conventional methods and apparatus for injecting viscous medicines suffer from a variety of problems such as excessive force during the initial needle insertion and initial injection. In an inventive method, during the initial phase of the injection, energy is stored in a torsion spring that is subsequently released during a later stage of the injection. The present invention also provides for an improved autoinjector; especially via the use of a combination compression and torsion spring that powers the injection through controlling force applied to a plunger via a screw flange or nut having pins that ride in a prescribed path down the length of the autoinjector.

Abstract: A method of providing and/or injecting octreotide acetate to a subject in need thereof includes storing the octreotide acetate in a cartridge of a multi-use multi-dose injector provided with a variable dose setter and actuator. The injector includes a needle configured for subcutaneous administration of the octreotide acetate, the octreotide acetate having a concentration of 2,500 ?g/mL. The method further includes providing, on the injector, a plurality of indicia only at prescribed doses of 50 ?g, 100 ?g, 150 ?g and 200 ?g settable via the dose setter without indicia between said prescribed doses; and permitting setting of a dose of the octreotide acetate by rotation of the variable dose setter, wherein the injector is configured to provide at least one audible feedback during the rotation.

Abstract: A prefilled injection pen for injecting insulin, the prefilled injection pen including: a screw rod, a memory connection barrel, a fixed barrel and a rotating barrel. A plurality of first one-way teeth is evenly distributed on an end surface of the rotating barrel. The memory connection barrel is disposed inside the rotating barrel. The inner wall of the memory connection barrel is provided with a protrusion matching a thread of the screw rod. An end face of one end of the fixed barrel is provided with a ratchet pawl matching the first one-way teeth. The fixed barrel is also provided with a first inner thread matching the screw rod. The screw rod is provided with two machined plane surfaces. A plunger is disposed at one end of the screw rod and a stopper is disposed in a thread groove at the other end of the screw rod.

Abstract: A sensor assembly comprising a first rotary sensor part with a plurality of individual electrically conducting axial position sensor segments arranged in a circumferential pattern, and a second rotary sensor part arranged rotationally relative to the first portion and comprising a plurality of circumferentially arranged electrically interconnected axial position contacts adapted to be arranged in contact with the axial position sensor segments. The assembly further comprises actuator means for axially moving the axial position contacts between a connected and a dis-connected position, wherein the axial position contacts and the axial position sensor segments are arranged such that for a given rotational position at least two axial position contacts each are in contact with a different axial position sensor segment.

Abstract: An autoinjector having a body (1) receiving a reservoir (S), the reservoir containing fluid and including a piston (P); a piston rod (5) adapted to co-operate with the piston (P) of the reservoir (S), the piston rod (5) movable by an injection spring (8) between a primed position and an injection position in which the piston rod (5) has moved the piston (P) of the reservoir (S); and an indicator device for indicating that the autoinjector may be removed from the injection site. The autoinjector includes a retarding system for delaying actuation of the indicator device relative to the end of injection, the retarding system including a dashpot (16) containing a fluid and a piston (19) arranged in the dashpot (16). The retarding system has the dashpot (16), the piston (19), a retarding spring (18), a locking key (20), and the piston rod (5), and the piston rod (5).

Abstract: A cap (120) for a drug delivery device (1) having a distal end (121) and a proximal end (122); the cap (120) having an opening at the proximal end and further comprising an outer cap element (130) and an inner cap element (131) being located inside the outer cap element (130), the inner cap element (131) comprising a deformable region (151) and a cap snap means (149); wherein the deformable region (151) of the inner cap element (131) is deformable into a gap (143) between the inner cap element (131) and the outer cap element (130).

Abstract: A protective dental needle includes a sheath having a cylindrical body with a channel along the cylindrical body. A needle assembly includes a hypodermic needle extending through a hub. The needle assembly is retained within the sheath and movable within the sheath between a retracted position and an extended position. A needle cap is positioned external to the sheath. The needle cap includes a plurality of longitudinal ribs that extend from an interior surface of the needle cap.

Abstract: Drug delivery devices that include a microphone and processing circuitry that can detect operating events, such as peak inspiratory flow (PIF) and Breath Actuated Mechanism (BAM) in dry powder inhalers can be used to improve clinical trials by providing information about the way in which the inhalers under test are being used.

Abstract: A pharmaceutical dispenser with a housing, a medium reservoir, a discharge opening, connection channel connecting the medium reservoir to the discharge opening, and a detection device arranged in the area of the connection channel and designed to detect medium flowing therein. The connection channel is connected to and communicates with a pressure chamber, the detection device includes a membrane which delimits the pressure chamber, and includes an electrically conductive connection portion and is subjected to pressure. The detection device has an electrical mating contact surface in relation to which a membrane-side connection portion is movable when subjected to pressure, such that an electrical contact between the conductive connection portion and the mating contact surface is established or cancelled.

Abstract: A delivery device for and method of modulating a condition relating to sodal cognition and/or behaviour in a human subject using oxytocin, non-peptide agonists thereof and/or antagonists thereof, comprising: providing a nosepiece to a first nasal cavity of the subject; and providing a supply unit for administering less than 24 IU of oxytocin, non-peptide agonists thereof and/or antagonists thereof through the nosepiece to an upper region posterior of the nasal valve which is innervated by the trigeminal nerve.

Abstract: Devices and methods for delivering fluid from a container to the nasal cavity. The device includes a selector and a nozzle that are connected together and rotatable relative to each other. The device includes a curve to overcome anatomical barriers and one or more openings to provide for effective distribution when delivering the fluid to the nasal cavity. The selector includes an opening that aligns with a corresponding opening in a container that holds the fluid. The nozzle includes a first passage with one or more openings on a first lateral side, and a second passage with one or more openings on an opposing second lateral side. The selector and nozzle can be positioned at a first and second rotational positions to selectively deliver the fluid through the first and second passages to the nasal cavity.

Abstract: A respiratory treatment apparatus generates an indication of inspiration or expiration based on a measure of motor current of a flow generator. In an example, first and second current signals are derived from the measurement. The first derived current signal may be a long term measure or average of current and the second derived current signal may be a short term measure or average of current. A processor (120) determines an indication of inspiration or expiration as a function of the first and second derived current signals. The function of the first derived current signal and the second derived current signal may be a comparison of the derived current signals. The derived signals may be determined by filtering. The indication of inspiration or expiration may serve as a trigger or cycle control for changing treatment pressure in synchrony with patient respiration without measured signals from pressure, flow or speed sensors.

Abstract: The present disclosure pertains to an apparatus configured to facilitate monitoring of gas in a therapeutic gas delivery system with a catalytic sensor. The gas delivery system comprises a pressure generator having an inlet and an outlet, and a gas delivery flow path configured to communicate the gas between the pressure generator and a subject. The apparatus comprises a receiver body configured to receive the catalytic sensor such that the catalytic sensor removably couples with the receiver body, the receiver body located remotely from/outside the gas delivery flow path; a delivery port configured receive a portion of gas obtained from the gas delivery system that has passed through the pressure generator outlet and guide the received portion of gas toward the catalytic sensor; and a return port configured to exhaust the received portion of gas from the receiver body to the gas delivery system through the pressure generator inlet.

Abstract: An exhaust valve shroud for a personal protection respiratory device, the shroud comprising a main body defining an inlet for receiving exhaled air from an exhalation valve, an outlet for emitting exhaled air from the shroud, and a perimeter flow conduit for carrying the exhaled air from the inlet to the outlet, wherein the perimeter flow conduit includes a bifurcated transition section which receives air from the inlet in a substantially forward facing direction and directs the air into first and second substantially downwardly extending flow passages, each of which passages are in communication with the outlet.

Abstract: The present document describes a facial interface comprising a flexible face contact layer configured to cover a user's face; and a nasal layer configured to sealably cover an external nose region of said user. The flexible face contact layer and nasal layer provide fluid circulation of air through said user's nostrils.

Abstract: One form of the present technology includes a sealing structure to seal against a user's face around the user's airways. The sealing structure includes a flap or membrane that extends inward towards the user's airways and includes a structure that prevents an inner boundary of the flap or membrane from being blown outwards (e.g., folded backwards upon itself) due to internal pressurization.

Abstract: A system of breathing arrangements for delivering breathable gas to a patient includes at least first and second cushion components, e.g., full-face, nasal, nasal prongs, nose tip, and/or a combination of any of the above, including a nasal or full-face cushion and nasal prongs/nozzles combination, etc., that are different from one another in at least one aspect, and a common frame assembly configured to support each of the first and second cushion components. Various embodiments are directed to a full-face or nasal mask used with a frame having lateral connector portions having a stiffening member. The mask assembly may include a nose height adjustment device for the height of the cushion, or a cushion adjustment member by which the position of the cushion may be adjusted relative to the frame. The mask assembly may include a chin strap assembly.

Abstract: An oxygen mask configured for CO2 sampling and oxygen delivery, the oxygen mask having an oxygen inlet, a nasal breath-sampling element and a breath sampling port configured to receive breath samples, sampled by the breath-sampling element, wherein the breath-sampling element is configured to reduce dilution of exhaled breath by the delivered oxygen.

Abstract: An oxygen delivery system provides controlled flow of oxygen-enriched gas to a patient. The system includes one or more sensors configured to measure respiration rate information and heart rate information of the patient. A computer system including one or more physical processors is operatively connected with the sensors. The physical processors are programmed with computer program instructions which, when executed cause the computer system to determine a metabolic oxygen consumption information of the patient from the respiration rate information and the heart rate information from the one or more sensors, and continuously adjust flow, volume and/or pressure of the oxygen-enriched gas delivered from an oxygen source of the oxygen delivery system to the patient based on the determined metabolic oxygen consumption information of the patient.

Abstract: Helically winding an extruded web to form a wall of a heated hose about a central axis, extruding a bead of plastics material around a heating wire such that the extruded bead comprises the heating wire at a first location within a cross-section of the extruded bead, helically winding the extruded bead onto the wall of the hose to provide a support helix, and exerting tension on the heating wire to draw down the heating wire toward the central axis such that the heating wire migrates radially inward from the first location to a second location within the cross-section of the extruded bead.

Abstract: A medical tube has a tube wall, a first end and a second end. At least one heater wire is wrapped around the wall. Near or at one of the first end or the second end, there is at least one recess in an outer surface of the wall. The heater wire passes over the at least one tube recess such that the wire does not contact the wall in the area of the tube recess. Also disclosed are methods of making the tube and components used in making the tube.

Abstract: An anti-explosion gas generator for health use is provided. The anti-explosion gas generator for health use includes an electrolysis device for electrolyzing water to produce a gas mixture of hydrogen and oxygen. The gas generator for health use further includes a gas mixing system coupled to the electrolysis device for receiving the gas mixture. The gas mixing system mixes the gas mixture with water vapor, an atomized medicine, a volatile essential oil or a combination thereof to produce a health gas. The health gas is provided for being inhaled by a user.

Abstract: A humidifier comprises a water reservoir and a reservoir dock configured to receive the water reservoir in an operative position. The water reservoir is configured to hold a volume of liquid. The water reservoir includes a chamber and a single conduit providing an inner opening arranged within the chamber. The reservoir dock includes a dock inlet conduit arranged to receive the flow of air from the RPT device. The dock inlet conduit is structured and arranged to extend within the single conduit of the water reservoir when the water reservoir reaches the operative position such that the dock inlet conduit and the single conduit at least partially overlap one another.

Abstract: A float retention arrangement and related methods for a humidification chamber that includes at least one float that operates an inlet valve that controls a flow of water through a water inlet opening of the humidification chamber. A cover of the humidification chamber defines an interior space, at least one gas port and a float retention opening. A component forms at least a portion of a water supply conduit for supplying water from a water source to the water inlet opening. The component is insertable into the float retention opening and is positionable to contact and retain the at least one float in a non-use position. In some configurations, the component can be a water spike.

Abstract: A sensory activity sack provides a garment with pleasant tactile features offering safe sensory stimulation for persons with developmental or sensory disabilities and an isolation bag for the wearer's arms and hands. The isolation bag prevents the wearer from engaging in self-injurious behavior or other harmful behaviors. Multiple fabrics and textures in the isolation bag, including mesh and denim, provide a pleasing tactile experience, which can be furthered by the placement of toys into the isolation bag. Sensory panels made with a sturdy, textured material such as denim provide tactile stimulation and resistance against wear and biting, as well as adding a comforting weight to the sensory activity sack for wearers with sensory issues.

Abstract: The present disclosure pertains to a system configured to adjust a volume of auditory stimulation delivered to a subject during sleep. The system is configured to determine a deepening time indicative of a rate at which sleep of the subject deepens during the sleep session. The deepening time is determined based on (i) a ratio of power in a high frequency band of an EEG signal to power in a low frequency band, (ii) a density of slow waves, or (iii) a hypnogram, indicative of sleep depth in the subject during the sleep session. The system is configured to determine a rate of volume increase for auditory stimulation during a subsequent sleep session based on the deepening time; and control the one or more sensory stimulators to adjust the volume of auditory stimulation provided to the subject during the subsequent sleep session based on the determined rate of volume increase.

Abstract: An infant calming/sleep-aid device that includes a moving platform and a sound generator, the sound and motion adapted to calm a fussy baby, induce sleep, and maintain sleep under normal conditions. The device makes a determination as to whether sound signals represent sound coming from inside the device or outside the device. If the sound signals are coming from the inside the device, then the signals are evaluated in a specified frequency band to determine whether the sound is a baby cry. If a determination is made that there is a baby cry, then a threshold analysis is performed to quantify the cry and compare it to a threshold value. If the cry is above a specified threshold, the device moves the platform and/or generates sound.

Abstract: A sleep induction device includes at least one sensor for detecting a physiological characteristic of the user, a stimulator configured to provide successive stimuli to the user to anticipate on the detected physiological characteristic, which successive stimuli define a guidance path, and which guidance path is to be followed by the user to induce a change during the sleep session of the user, a memory which is arranged to store values of detected physiological characteristics, and provided stimuli during the sleep session, and a processing unit including a control programme which is programmed to determine a current sleep state of the user, which current sleep state is based on at least one detected physiological characteristic measured by the at least one sensor and which control programme is programmed to generate an initial guidance path to induce a change from the determined current sleep state to another sleep state.

Abstract: A seat assembly includes a seat having a seat base and a seat back, an electronic control unit (ECU), a sensor assembly, and/or a response assembly. The ECU may be configured to determine via the sensor assembly whether an occupant disposed in the seat is in a first state, a second state, or a third state. The ECU may be configured to control the response assembly to change the state of said occupant from the first state to the second state and from the third state to the second state. The ECU may be configured to determine at least one of a breathing rate, a heart rate, and a heart rate variability of said occupant via the sensor assembly.

Abstract: Apparatuses and methods described herein relate to treating cancerous tumors using radiation therapy and chemotherapy. In some embodiments, a method of treatment includes administering radiation therapy targeting a tumor, isolating a segment of a vessel proximate to the tumor, and administering a dose of a chemotherapeutic agent to the segment of the vessel. The method can further include waiting a period of time after administering the radiation therapy before administering the dose of the chemotherapeutic agent. In some embodiments, a catheter device including first and second occluding elements can be used to isolate the segment of the vessel.

Abstract: There is provided an apparatus for use in a bodily lumen. The apparatus comprises a guidewire and a catheter. The guidewire has a proximal end portion and a distal end portion. The catheter has a proximal end portion and a distal end portion. The catheter includes a lumen for receiving the guidewire. The catheter is configured to be translated along the guidewire. The catheter is configured to be biased towards a translated position along the guidewire by a magnetic attraction between the guidewire and the catheter.

Abstract: Steerable medical devices and methods of use. In some embodiments, the steerable medical devices can be steered bi-directionally. In some embodiments the steerable medical devices include a first flexible tubular member and a second flexible tubular member secured together at a location distal to a steerable portion of the steerable medical device.

Abstract: A deflectable catheter shaft section is disclosed comprising an elongated body extending along a longitudinal axis and comprising a distal end and a proximal end; and a plurality of lumens extending along the longitudinal axis of the elongated body, wherein at least one of the lumens is abutting at least another one of the lumens. A catheter comprising the deflectable catheter shaft section and a method of manufacturing the deflectable catheter shaft section are also disclosed. A catheter incorporating a deflectable catheter shaft section can further comprise first and second compression coils disposed over pull wires located within the catheter, wherein the compression coils are unattached to the catheter or components thereof, but can be constrained by a shaft coupler at a distal end of each of the compression coils and by at least a portion of a handle assembly at a proximal end of each of the compression coils.

Abstract: The present disclosure relates to guidewire devices having shapeable tips and effective torquability. A guidewire device includes a core having a proximal section and a tapered distal section. A tube structure is coupled to the core such that the tapered distal section extends into the tube structure. The tube structure includes a plurality of bypass cuts formed tangentially within the tube structure to increase the flexibility of the tube structure and to reduce the tendency of resilient forces from the tube structure to disrupt a shaped distal tip of the guidewire device.

Abstract: A guidewire system for spine surgeries includes a first guidewire portion having an elongate first guidewire body with a distal end and a proximal end. A threaded male fastener at the distal end of the first guidewire body is configured to fasten to a vertebra of a spine of a subject and a threaded female coupler at the proximal end of the first guidewire body defines a threaded opening. The guidewire system includes a second guidewire portion having an elongate second guidewire body with a distal end and a proximal end. A threaded male coupler at the distal end of the second guidewire body is configured to thread into the threaded female coupler of the first guidewire portion to fasten the second guidewire portion to the first guidewire portion to form an elongate guidewire.

Abstract: The present disclosure relates to implantable encapsulation devices for housing a biological moiety or a therapeutic device that contains a biological moiety. Particularly, aspects of the present disclosure are directed to an implantable apparatus that includes a distal end, a proximal end, a manifold including at least one access port positioned either at the distal end or the proximal end, and a plurality of containment tubes affixed to the manifold and in fluid communication with the at least one access port. Additionally, the encapsulation device may contain a flush port and a tube that are fluidly connected to the manifold. The containment tubes may contain therein a biological moiety (e.g., cells) or a therapeutic device (e.g. a cell encapsulation member).

Abstract: Devices and methods for using and manufacturing microstructure arrays having at least a detachable distal area are described.

Abstract: A needle assembly for a liquid applicator comprises housing with longitudinal channel. The channel comprises upper and lower open ends. A needle bundle is movably mounted in the channel, which comprises needle shaft and needles attached thereto. A biasing member is configured and mounted for (i) biasing the needle bundle longitudinally towards a retracted position and (ii) biasing the needles laterally towards a needle-guiding side wall of the housing adjacent the lower open end. The biasing member is configured and mounted to form a fluid seal between the lower and upper open ends. The biasing member comprises an elastic tubular section with opposite sides. The first side has a first rectified length. The second side has a second rectified length longer than the first rectified length so that the second side is less tensioned than the first side to bias the needles towards the needle-guiding side wall.

Abstract: A tube for a medical container has a tube wall which consists of at least two layers. According to the invention, at least one layer contains a styrene-containing thermoplastic polymer (S-TPE), in particular a styrene-butadiene block copolymer (SBC) or a copolyester, a copolyester ether or a cyclic olefin copolyester. The at least one other layer contains ethylene-vinyl acetate copolymer (EVA), preferably with a vinyl acetate (VA) portion in the ethylene-vinyl acetate copolymer of from 10% to 30%, preferably 14% to 28%. The EVA can be mixed with a thermoplastic polybutene and/or SEBS to improve the tube properties. The tube wall can have a two-layer structure with an inner or an outer layer which contains the S-TPE, copolyester, copolyester ether or cyclic olefin copolyester, or a three-layer structure with an outer and inner layer containing the S-TPE or copolyester or copolyester ether.

Abstract: A connector-with-integrated-check-valve for minimizing microbial migration to catheter-tubing is formed from three parts: a connector-for-catheter-tubing that is hollow and with an internal valve seat; an elastomer gate (sometimes with disc and stem); and a connector-for-extension-tubing that is hollow and with support-surfaces.

Abstract: Levers (30) are connected to a base end portion (13) of a male luer via a base (15). Each lever includes a locking portion (31) and an operating portion (35). A locking claw (32) protrudes from each locking portion toward the male luer. A lock ring (8) is provided opposing inner surfaces of the operating portions. The lock ring is movable between a first position at which the lock ring is located close to the base and a second position at which the lock ring is located away from the base. When the lock ring is at the first position, the levers are pivotable such that the locking claws move away from the male luer. When the lock ring is at the second position, the lock ring restricts the levers from pivoting such that the locking claws move away from the male luer.