Abstract: An oxygen saturation measuring apparatus capable of measuring arterial blood oxidation saturation (SpO2), and tissue oxygen saturation (rSO2), safely, easily and economically at a desired position of a biological body for a long time continuously. A ROM stores the distance information between a light emitting unit and a light receiving unit situated corresponding to the depth of a target intended to be measured for tissue oxygen saturation, a light emission driving unit makes the light emitting unit emit light in an amount of light corresponding to the distance information, MPU makes the light emitting unit emit a pulses capable of measuring the tissue oxygen saturation, MPU applies pulse capable of measuring the tissue oxygen saturation from the light emission driving unit to the light emitting unit, and the pulse increasing unit increases the amount of pulses from MPU for a predetermined time to pulses capable of measuring the arterial blood oxygen saturation.

Abstract: A spectrophotometric apparatus for determining optical parameters in a scattering medium based on the measurement of attenuation of light propagating through said medium by diffusion. To eliminate the detrimental effect of light being guided in an intermediate optical layer between a surface of the medium and a contact surface of the apparatus, either a multitude of optical barriers may be formed in the contact surface or the angular range over which light is emitted or received by the apparatus may be limited by appropriate means. With both of these alternative approaches, light propagation in the intermediate layer can be suppressed, leading to increased measurement accuracy. This is particularly beneficial for building an oximeter with improved precision. Further aspects include features for improving the applicability of the apparatus on curved surfaces such as the strongly curved skulls of neonates.

Abstract: Methods and systems are provided for a pulse oximetry probe configured to measure blood originating from the internal carotid artery. One example system includes a light emitter and a light detector coupled to a substrate and an attachment mechanism configured to couple the nasal pulse oximetry probe to a nose of a patient, the light emitter and light detector positioned on opposite sides of the nose at the root of the nasal bridge. One example method determines peripheral arterial oxygen saturation (SpO2) respiratory variability as well as other physiological parameters from measurements taken from the internal carotid artery.

Abstract: A method of assessment of renal function by monitoring a time-varying fluorescence signal emitted from a fluorescent agent from within a diffuse reflecting medium with time-varying optical properties is provided that includes using a renal monitoring system comprising at least one light source, at least one light detector, at least one optical filter, and at least one controller to provide a measurement data set comprising a plurality of measurement entries, each measurement data entry comprising at least two measurements obtained at one data acquisition time from a patient before and after administration of the fluorescent agent.

Abstract: The present invention relates to a system and method for determining at least one vital sign of a subject.

Abstract: Multiple analytes may be dysregulated singularly or concurrently in certain physiological conditions and may be advantageously assayed together using analyte sensors capable of detecting multiple analytes. Certain analyte sensors capable of the detection of multiple analytes may include first and second working electrodes, analyte-responsive active areas disposed on each of the working electrodes, and reference and counter electrodes. Analyte sensors that include multiple working electrodes but do not include reference and counter electrodes can also be used in conjunction with another sensor that contains reference and counter electrodes, such that these electrodes are shared.

Abstract: An apparatus for insertion of a medical device in the skin of a subject is provided.

Abstract: An apparatus for insertion of a medical device in the skin of a subject is provided.

Abstract: An apparatus and method for collecting a predetermined amount of blood or other fluid using an automated sampling system is provided.

Abstract: A biological liquid collection device designed to draw blood using an “atmospheric-balanced vacuum” to ensure the blood is exposed to the sample atmospheric partial pressure oxygen and partial pressure carbon dioxide levels as found in standard arterial blood gas syringes, resulting in blood gas sample stabilization during collection and a superior vacuum shelf-life by reducing the gas permeation rate through the plastic tube. The biological liquid collection device comprises a collection module for receiving a biological liquid sample, an evacuated container having an open end and a closed end wherein the evacuated container contains the collection module therein, and a closure for closing the open end of the evacuated container. The evacuated container comprises a gas composition that is substantially equal to the gas composition of the atmosphere outside of the evacuated container. A method for forming the atmospherically balanced vacuum collection device is also provided.

Abstract: A biological fluid collection system (10) including a collection module (14) for collecting a small sample of blood and transferring a portion of the sample into a device or instrument for analyzing the sample such as a point-of-care or a near-patient-testing device including blood collection devices for collecting and transferring venous and arterial blood samples are disclosed.

Abstract: The present disclosure relates to a method, device, and system for emotion intervention, as well as a computer-readable storage medium and a healing room. The emotion intervention method includes: identifying a user's emotion state according to the user's first biometric information; and recommending at least one emotion intervention corresponding to the emotion state.

Abstract: The present disclosure relates to the field of schizophrenia or an autism spectrum disorder (“ASD”) diagnostics and disease management. Specifically, the present disclosure teaches a method of assessing schizophrenia or ASD in a subject in which a subject's usage data for a mobile device is collected over a first predefined time window. A usage behavior parameter is determined from the usage data, and the determined usage behavior parameter is compared to a reference. From the comparison it may be determined whether the schizophrenia or ASD in the subject is improving, persisting or worsening. A system including a mobile device having sensors recording usage data and a remote device operatively linked to the mobile device is also disclosed.

Abstract: A system and method for screening and monitoring progression of subjects' health conditions and wellbeing, by the analysis of their voice signal. According to one embodiment, a system is provided that records voice samples of subjects and evaluates, in real time, the severity of their health condition based on vitality biomarkers. The vitality biomarkers are the construct of machine learning and deep learning models trained in an offline procedure. The offline training procedure is optimized to associate between (a) acoustic features and/or image representations of training cohort subjects' pre-recorded voices; and (b) their vitality score, extracted from their medical records. In the training procedure, the vitality scores of the training cohort subjects is heuristically defined as a function of the speaker age at the time of recording and the duration elapsed between the time of recording and available clinical events, with emphasis on the time of death when available.

Abstract: The present invention provides an intelligent attention rehabilitation system, which includes a gaze tracking module, an attention evaluation module, an intelligent computation and program push module, a data storage module, and an assessment and feedback module. In the invention, based on the theoretical CMA, data on attention level is acquired; and the advantages of simple configuration requirements and low cost of the gaze tracking technology, and intelligent computation of AI algorithms are used, to digitally evaluate attention of a subject. Besides, the DQN algorithm is used to realize intelligent push of related attention training guidance and programs, to solve the problem of family attention rehabilitation training under the lack of scientific guidance in the market currently, thereby providing a more scientific and accurate family attention rehabilitation evaluation and training system for the need.

Abstract: A muscle activity sensor includes a base textile, an electrode, and an interconnect. The base textile is configured to apply a compression force against a dermal surface of the user. The electrode is coupled to the base textile and includes a sensor layer including a conductive textile coupled to a dermal side of the base textile. The sensor layer is configured to receive electrical signals associated with muscle activity of the user. The electrode may also be configured to provide the electrical signals as an output signal. The interconnect may be coupled to the base textile over a distance from the electrode to an interconnect junction contact such that the interconnect moves with the base textile as the user moves. The interconnect may be further configured to deliver the output signal from the electrode to the interconnect junction contact.

Abstract: The electrode for recording a physiological electrical signal of a living being made from electrically conductive material and including a body having a front surface and a rear surface for electrical contact, the electrode further including a rigid mounting element attached to the body, at an edge of the rear electrical contact surface and designed so as to produce a removable mounting of the electrode on a recording sensor.

Abstract: Provided is a method of analyzing electrical characteristics of nerves, the method including generating an input electrical signal to be applied to a nerve, obtaining an output electrical signal based on measuring a nerve signal generated from the nerve in response to the input electrical signal, obtaining output frequency components, which are frequency components of the output electrical signal, based on converting the output electrical signal into a frequency domain, and obtaining conductance of the nerves and capacitance of the nerves based on the output frequency components.

Abstract: A system and method for cardiac activation imaging includes non-invasively or minimally invasively acquiring data about an electrical activation of a heart of a subject using at least one sensor. An activation image of the heart of the subject is reconstructed using a weighted sparse constrained reconstruction.

Abstract: A system and method for non-invasively generating a report of cardiac electrical activities of a subject includes determining, using cardiac electrical activation information, equivalent current densities (ECDs). The ECDs are assembled into time-course ECD information and a spectrum of the time-course ECD information is analyzed to determine peaks for spectral characteristics of atrial fibrillation (AF). The spectral characteristics of AF are correlated with potential electrical sources of the AF and a report is generated indicating the potential electrical sources of the AF spatially registered with the medical imaging data.

Abstract: This document describes methods and materials for mapping and modulating repolarization. For example, this document relates to methods and devices for mapping and modulating repolarization to target atrial and ventricular arrhythmias to deliver electrical stimulation pacing, ablation and/or electroporation.

Abstract: A method for monitoring specific activity parameters of the human heart, where ECG and PCG signal monitoring is performed simultaneously by at least two electrodes placed on the chest in such a way that the ECG signal is utilized as a reference time point during PCG monitoring, and monitoring is performed with a measuring unit consisting of a couple of measuring heads containing combined ECG and PCG electrodes, a controlling master measuring head and a slave measuring head performing synchronized implementation, and a computing evaluating unit which is in wireless data communication connection with the above unit and is capable of data processing. ECG and PCG signals are simultaneously monitored by two measuring heads, each comprising an ECG electrode and a PCG electrode, one of the measuring heads serving as a master measuring head and the other one of the measuring heads serving as a slave measuring head.

Abstract: Methods and apparatuses, including devices and systems, for remote and detection and/or diagnosis of acute myocardial infarction (AMI). In particular, described herein are handheld and adhesive devices having an electrode configuration capable of recording three orthogonal ECG lead signals in an orientation-specific manner, and transmitting these signals to a processor. The processor may be remote or local, and it may automatically or semi-automatically detect AMI, atrial fibrillation or other heart disorders based on the analyses of the deviation of the recorded 3 cardiac signals with respect to previously stored baseline recordings.

Abstract: The technology relates to medical equipment, namely, to a medical chair for recording an electrocardiogram in the first lead («1-lead»), and can be used in medical institutions, pharmacies, public organizations and at home. Chair for measuring electrocardiogram in the first lead containing: two dry capacitive contact electrodes, each is attached to the appropriate armrest; wherein electrodes are made in the form of handles and configured in such a way as to enable the user to hold onto them with their palms in a sitting position; wherein electrodes are adapted to connect them to the lead cable for connection with the electrocardiograph, wherein electrodes are isolated from the chair frame through a dielectric spacer, wherein the electrocardiograph holder is attached to the chair so that the electrocardiograph secured in the holder is at user eye level.

Abstract: In one embodiment, a medical system includes respective electrodes for application to a body of a subject and to output a set of respective activation signals in response to electrical activity of a heart of the subject captured over a sequence of heartbeat intervals, and a processor to classify a first heartbeat interval of the set of activation signals as a first morphological template, compute a measure of similarity between a second heartbeat interval of the set of activation signals and the first morphological template, group the second heartbeat interval of the set of activation signals in a first morphological group with the first morphological template responsively to the measure exceeding a predefined threshold, and classify the second heartbeat interval of the set of activation signals as a second morphological template responsively to the measure not exceeding the predefined threshold, and repeat the above, mutatis mutandis, for subsequent heartbeat intervals.

Abstract: The present disclosure provides electroretinography devices configured to detect biopotential signals from an eye of a subject. In some embodiments, the device is configured to prevent the subject's eyelids from closing over the device when placed in contact with the anterior surface of the subject's eye. In some embodiments, the device has a Young's modulus of no more than about 50 MPa. In some embodiments, the device includes a diffusing or refracting element configured to scatter, focus or diverge incident light. In other embodiments, the device includes a void through which incident light can enter the subject's eye without passing through any portion of the device.

Abstract: A method and an apparatus for analyzing heart rate Variability (HRV), and use thereof are provided. A low-cost, portable and wearable signal acquisition device is utilized to acquire electrocardiography (ECG) signals of epilepsy patients for 24 hours before treatment, and a time domain index, a frequency domain index and a nonlinear index of the ECG during a long term and during a short term are calculated with a programmed HRV analysis method, and the efficacy of vagus nerve stimulation (VNS) treatment for patients with medically intractable epilepsy is accurately and efficiently predicted based on characteristic parameters for characterizing an effect level of the vagus nerve regulating the heart rate, i.e., vagus nerve activity, thereby avoiding unnecessary costs and avoiding the delay of the optimal treatment timing. In addition, the characteristic parameters obtained by the HRV analysis on the ECG may be utilized to clearly select VNS treatment indication patients.

Abstract: Dimensions of a surface feature are determined by capturing an image of the surface feature and determining a scale associated with the image. Structured light may be projected onto the surface, such that the position of structured light in the captured image allows determination of scale. A non-planar surface may be unwrapped. The surface may alternatively be projected into a plane to correct for the scene being tilted with respect to the camera axis. A border of the surface feature may be input manually by a user. An apparatus and system for implementing the method are also disclosed.

Abstract: Provided is an obstructive sleep apnea syndrome diagnosis method using machine learning. An embodiment of the present invention is directed to providing an obstructive sleep apnea syndrome diagnosis method using machine learning, which diagnoses obstructive sleep apnea syndrome by extracting parameters related to obstructive sleep apnea syndrome from a geometrical shape of an airway and performing machine learning using data calculated through simulation. Another embodiment of the present invention is directed to providing an obstructive sleep apnea syndrome diagnosis method using machine learning, which improves accuracy of diagnosis of obstructive sleep apnea syndrome and proposes a quantitative standard by diagnosing the obstructive sleep apnea syndrome from the geometrical shape of the airway as described above.

Abstract: A medical system worn by an individual comprising in certain embodiments a central processing unit, a memory unit containing programming and diagnostic values, a global positioning system unit, a wireless communications component, at least one physiologic sensor, and at least one medicament administration device containing at least one active pharmaceutical ingredient.

Abstract: A patient health management platform accesses a metabolic profile for a patient and biosignals recorded for the patient during a current time period comprising sensor data and/or lab test data collected for the patient. The platform receives patient data recorded during the current time period comprising food items consumed, medications taken, and symptoms experienced by the patient. The platform implements a machine-learned metabolic model to determine a metabolic state of the patient at a conclusion of the current time period by comparing a true representation of the metabolic state and a prediction of the metabolic state. The true representation and the prediction are determined based on the recorded biosignals and the recorded patient data, respectively. The platform generates a patient-specific treatment recommendation outlining instructions for the patient to improve their metabolic state and provides the patient-specific treatment recommendation to the patient device for display to the patient.

Abstract: A neurological screening device and method for assessing brain dysfunction of a subject including a projection apparatus configured to project an image onto retinas of a subject, detectors configured to capture light reflected from the retinas, the reflected light indicating a fixation of the eyes, a controller configured to generate baseline cognitive performance data based at least in part on a presence or absence of fixation, cause output of a plurality of assessment images on displays of the neurological screening device, the plurality of assessment images corresponding to a cognitive assessment configured to stress the frontal lobe of the subject, generate stressed cognitive performance data based at least in part on a presence or absence of fixation during the cognitive assessment, and determine brain dysfunction of the subject based at least in part on the baseline cognitive performance data and the stressed cognitive performance data.

Abstract: A device for electrostimulation or for data acquisition by diagnostic instruments has at least one electrode unit with the following layers: a) base layer with at least one electrode disposed in or on the base layer, and b) layer with one of the following layer structures: b1) plastic layer and layer of knitted fabric and plastic layer or b2) layer of knitted fabric and plastic layer or b3) plastic layer and layer of knitted fabric. The layers a) and b) are joined tightly with one another.

Abstract: Apparatuses, systems, and methods are disclosed for noninvasively locating and measuring tissue based on real-time feedback. An apparatus includes a probe comprising an interrogation electrode that is configured to measure electrical impedance of tissue of a patient's body between the interrogation electrode and a reference electrode. An apparatus includes a processor and a memory that stores code executable by the processor to apply, noninvasively, an electrical current using the interrogation electrode of the probe to a location on the patient's body to locate and measure an electrical impedance of the tissue of the patient, measure electrical impedance of the tissue between the interrogation electrode of the probe and the reference electrode, and adjust a location of the probe on the patient's body according to feedback based on the measured electrical impedance of the tissue.

Abstract: The application belongs to the field of earphone technology, and discloses a type of monitoring earphones intended for autism spectrum disorder. The upper part of headband is fixed with an electroencephalogram signal sensor, and the two sides thereof are respectively secured with No. 1 buckle and No. 2 buckle, which are used to fix No. 1 No. 1 signal processor and No. 2 signal processor on the upper part of the headband. Once the user is found by the application to be not himself/herself, the earphone will play his/her favorite music with Bluetooth, serving the function of music therapy.

Abstract: The biological information measurement device comprises: an adhesive tape having on its bottom side an adhesive surface to be affixed to the skin of a user; a mounting substrate disposed on the top side of the adhesive tape; a guide needle insertion cylinder provided on the top side of the adhesive tape, on which the mounting substrate is held; a sensor electrically connected to the mounting substrate for measuring biological information; and a cover covering the top side of the mounting substrate. The bottom side of the mounting substrate is in a state of not being affixed to the top side of the adhesive tape, and the adhesive tape and the cover are more stretchable than the mounting substrate.

Abstract: The problem is to provide a probe holder for fixing, using a simple configuration, a plurality of probes in a state in which the positional relationships of the probes are defined. To solve the problem, provided is a probe holder for holding probes for emitting or detecting light and attaching the probes to the head of a subject, the probe holder including: a plurality of basic units each holding three of the probes with a single plate; and a plurality of couplers each linking a respective one of the three of the probes and adjacent probes to form a plurality of adjacent probes that are linked at a point equidistant from the plurality of adjacent probes, each probe in the plurality of adjacent probes being included in a different one of the plurality of basic units.

Abstract: The disclosure provides tissue force sensor systems and methods for tissues, e.g., laryngeal tissue. The systems include a top housing including on an upper side an attachment mechanism for connecting the top housing to a medical device, e.g., a laryngoscope, and on a lower side a first cavity for receiving a top portion of a force measurement device such as a load cell; a bottom housing including on a lower side an attachment mechanism for connecting the bottom housing to a handle, holding system, or suspension system for holding or supporting the medical device, and on an upper side a second cavity for receiving a bottom portion of the force measurement device; and an attachment device for connecting the top housing to the bottom housing.

Abstract: The present embodiments relate generally to applicators of on-skin sensor assemblies for measuring an analyte in a host, as well as their method of use and manufacture. In some aspects, an applicator for applying an on-skin sensor assembly to a skin of a host is provided. The applicator includes an applicator housing, a needle carrier assembly comprising an insertion element configured to insert a sensor of the on-skin sensor assembly into the skin of the host, a holder releasably coupled to the needle carrier assembly and configured to guide the on-skin sensor assembly while coupled to the needle carrier assembly, and a drive assembly configured to drive the insertion element from a proximal starting position to a distal insertion position, and from the distal insertion position to a proximal retraction position.

Abstract: The present embodiments relate generally to applicators of on-skin sensor assemblies for measuring an analyte in a host, as well as their method of use and manufacture. In some aspects, an applicator for applying an on-skin sensor assembly to a skin of a host is provided. The applicator includes an applicator housing, a needle carrier assembly comprising an insertion element configured to insert a sensor of the on-skin sensor assembly into the skin of the host, a holder releasably coupled to the needle carrier assembly and configured to guide the on-skin sensor assembly while coupled to the needle carrier assembly, and a drive assembly configured to drive the insertion element from a proximal starting position to a distal insertion position, and from the distal insertion position to a proximal retraction position.

Abstract: A system for obtaining signals related to electrical activity of the heart of a subject includes a sensing device including an elongate member having a distal end configured for placement within a body lumen of a subject, and a proximal end configured to extend from the subject, an actuation portion carried by the elongate member and configured for placement within the body lumen, the actuation portion having a low-profile state for delivery within the body lumen and an expanded state, and one or more sensors disposed on the actuation portion, each including a contact surface configured to contact an interior wall of the body lumen, wherein the actuation portion is configured to cause the contact surface of each of the one or more sensors to contact a location on the interior wall of the body lumen to provide a signal component for producing one or more electrocardiogram signals.

Abstract: The present disclosure provides methods and devices for assessing movement. In some exemplary embodiments, a system for assessing movement is provided. In some embodiments, the system includes a handheld device. In some embodiments, the handheld device includes a plurality of sensors configured to record motion and position data, a body having a plurality of sides, a battery, and a proximal end configured to interact with a touchscreen of a computing device.

Abstract: There is provided a computer-implemented method for analysing echocardiograms, the method comprising: obtaining (302) a plurality of pairs of consecutive echocardiograms for a plurality of subjects from a database (200), each echocardiogram having an associated indication of the content of the echocardiogram; analysing (304) each pair of consecutive echocardiograms to determine an associated class, the class indicating whether there is a change or no change between the consecutive echocardiograms in the pair; for each pair of consecutive echocardiograms, determining (306) an abstract representation of each echocardiogram by performing one or more convolutions and/or reductions on the echocardiograms in the pair, the abstract representation comprising one or more features indicative of the class of the pair; and training (308) a predictive model to determine a class for a new pair of echocardiograms based on the abstract representations for the plurality of pairs of consecutive echocardiograms.

Abstract: A method of predicting the risk of experiencing symptoms related to abnormal blood pressure and/or heart rate that includes obtaining subject heart rate variability data representing a number of HRV parameters, wherein the subject HRV data is generated based on heartbeat data obtained from an individual wearing a heart parameter sensor, providing the subject HRV data as an input to an artificial intelligence system, wherein the artificial intelligence system has been previously trained using training and test HRV data representing the number of HRV parameters obtained from a plurality of test subjects, and analyzing temporal data changes in or indicated by the subject HRV data in the artificial intelligence system to determine whether the individual is at risk of experiencing symptoms related to abnormal blood pressure and/or heart rate placing them at risk of a fall.

Abstract: An integrated bioinstrumentation system, combining an accurate and robust quasi 1D computational model with experimental peripheral measurements, is designed to extract information on other quantities of interest, for which the direct measurements are not feasible. The system is able to quantify and visualize the distributions of a cardiac output (CO), aortic blood pressure (BP), flow, velocity, and aortic arterial compliance, based on a peripheral analysis of a pulse transit time (PTT) measured at the available peripheral sites. A preliminary calibration stage extracts the arterial properties from simultaneous measurements of a pulse transit time, and an upper arm blood pressure. Obtained transfer functions, linking noninvasive peripheral measurements to the aortic pressure, cardiac output, aortic compliance and others serve to quantify the indicators of cardiac morbidity and mortality.

Abstract: A method includes receiving motion data from at least one sensor of a wearable device worn by a user. The method further includes receiving audio data from at least one sensor of the wearable device, the audio data representative of sounds emanating from the user's respiratory system. The method further includes comparing the motion data to a motion data criteria. The method further includes comparing the audio data an audio data criteria. The method further includes determining, based on the comparison of the motion data to the motion data criteria and the comparison of the audio data to the audio data criteria, whether the user has coughed.

Abstract: Described herein are paddles for breast biopsies. A reverse paddle and a compression paddle may be used in a breast biopsy. Both paddles may each have an aperture. When pressed against the breast, the reverse paddle and the compression paddle may allow the breast to bulge out of the aperture of both paddles during the biopsy. As the breast tissue bulges out of both paddles, the breast tissue to be examined via biopsy may be enlarged, thereby lessening the use of excisional biopsies on subjects with thin breasts.

Abstract: A mobile platform includes a chassis, a sensor module and at least one holding mechanism. In an embodiment, the at least one holding mechanism is designed to guide a first medical device and is configured to position the first medical device in at least one operating position within an adjusting range.

Abstract: The necessary detector configuration and mathematical algorithms to implement a lateral (side-viewing) field of view in a gamma detection probe designed for laparoscopic use is disclosed. For this application, the diameter of the probe is limited to 12 mm. A hybrid collimation design, using a combination of both electronic collimation and metallic shielding, allows the probe to detect gamma emissions form 15 KeV-1.0 MeV. In the lower energy range, the 1.52 mm tungsten shielding is sufficient to collimate the primary detector. Two additional detectors are used to provide electronic collimation and depth detection. The upper energy limit of 1.0 MeV is imposed to exclude the possibility of electron-positron pair production which occurs at energies of 1.022 MeV and greater.

Abstract: A digital radiographic detector system includes a number of DR detectors enclosed by a housing. A base section with wheels has attached thereto a vertical column with a height adjustable horizontal arm extending therefrom. The housing with DR detectors therein is attached to a distal end of the horizontal arm. The housing comprises a major surface made from a radiolucent material to allow the detectors to capture radiographic images via x-rays transmitted through the major surface of the housing. The housing is configured to support the plurality of DR detectors therewithin.