Patents Issued in November 9, 2021
  • Patent number: 11167041
    Abstract: Provided herein are variant adeno-associated virus (AAV) capsid proteins having one or more modifications in amino acid sequence relative to a parental AAV capsid protein, which, when present in an AAV virion, confer increased infectivity of one or more types of retinal cells as compared to the infectivity of the retinal cells by an AAV virion comprising the unmodified parental AAV capsid protein. Also provided are recombinant AAV virions and pharmaceutical compositions thereof comprising a variant AAV capsid protein as described herein, methods of making these rAAV capsid proteins and virions, and methods for using these rAAV capsid proteins and virions in research and in clinical practice, for example in, e.g., the delivery of nucleic acid sequences to one or more cells of the retina for the treatment of retinal disorders and diseases.
    Type: Grant
    Filed: November 18, 2020
    Date of Patent: November 9, 2021
    Assignee: 4D MOLECULAR THERAPEUTICS INC.
    Inventors: David H. Kirn, Melissa Kotterman, David Schaffer
  • Patent number: 11167042
    Abstract: Provided herein are materials and methods for efficiently delivering nucleic acids to cochlear and vestibular cells.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: November 9, 2021
    Assignees: Massachusetts Eye and Ear Infirmary, Schepens Eye Research Institute, Children's Medical Center Corporation
    Inventors: Konstantina Stankovic, Luk H. Vandenberghe, Jeffrey Holt, Gwenaelle Geleoc
  • Patent number: 11167043
    Abstract: The present invention provides, among other things, methods of treating ornithine transcarbamylase deficiency, including administering to a subject in need of treatment a composition comprising an mRNA encoding an ornithine transcarbamylase protein at a low dose and at an administration interval such that at least one symptom or feature of the OTC deficiency is reduced.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: November 9, 2021
    Assignee: TRANSLATE BIO, INC.
    Inventors: Kim Askew, Jou-Ku Chung, Frank DeRosa, Michael Heartlein, Shrirang Karve, Thomas McCauley, Lianne Smith, Ann J. Barbier
  • Patent number: 11167044
    Abstract: Methods for producing new neurons in the brain in vivo are provided according to aspects of the present invention which include introducing NeuroD1 into a glial cell, particularly into a reactive astrocyte or NG2 cell, thereby “converting” the reactive glial cell to a neuron. Methods of producing a neuronal phenotype in a glial cell are provided according to aspects of the present invention which include expressing exogenous NeuroD1 in the glial cell, wherein expressing exogenous NeuroD1 includes delivering an expression vector, such as a viral expression vector, including a nucleic acid encoding the exogenous NeuroD1 to the glial cell.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: November 9, 2021
    Assignee: The Penn State Research Foundation
    Inventors: Gong Chen, Lei Zhang, Zheng Wu, Yuchen Chen, Fan Wang, Ziyuan Guo
  • Patent number: 11167045
    Abstract: Provided herein is chitosan-derivative nanoparticle comprising chitosan functionalized with a cationic amino acid and a hydrophilic polyol; and methods of making and using same, e.g., for gene delivery in vivo.
    Type: Grant
    Filed: October 28, 2019
    Date of Patent: November 9, 2021
    Inventors: Jun Gao, Eric Hsu, Anthony Cheung
  • Patent number: 11167046
    Abstract: A method for organ imaging, comprising: administering to a subject a diagnostic effective amount of 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate or 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-(4-sulfonatophenoxy)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate. In one embodiment, the organ includes one or more of kidney, bladder, liver, gall bladder, spleen, intestine, heart, lungs and muscle.
    Type: Grant
    Filed: November 18, 2019
    Date of Patent: November 9, 2021
    Assignee: LI-COR, INC.
    Inventors: Daniel R. Draney, William M. Volcheck, Katie Schaepe, Vassil Elitzin, Joy Kovar
  • Patent number: 11167047
    Abstract: An imaging nanoparticle comprising a plant virus particle having an interior surface and an exterior surface, an imaging agent that is linked to the interior and/or exterior surface, and a layer of biocompatible mineral such as silica coated over the exterior surface, is described. The imaging nanoparticle can be used in method of generating an image of a tissue region of a subject, by administering to the subject a diagnostically effective amount of an imaging nanoparticle and generating an image of the tissue region of the subject to which the imaging nanoparticle has been distributed.
    Type: Grant
    Filed: February 19, 2019
    Date of Patent: November 9, 2021
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Nicole F. Steinmetz, Michael Bruckman, Lauren Randolph
  • Patent number: 11167048
    Abstract: Disclosed are compositions and methods relating to prostate cancer. In particular, disclosed are bivalent targeting ligands that specifically bind prostate specific membrane antigen and gastrin-releasing peptide receptor. Bivalent binding agents disclosed herein can be used to image a tissue in a subject in need thereof and to diagnose prostate cancer in a subject in need thereof. Bivalent binding agents disclosed herein can be used to treat prostate cancer in a subject in need thereof.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: November 9, 2021
    Assignee: The Curators of the University of Missouri
    Inventors: Charles Jeffrey Smith, Rajendra Prasad Bandari
  • Patent number: 11167049
    Abstract: A method of reducing radiation exposure of a non-cancerous tissue of a patient diagnosed with a cancer includes administering to the patient an agent capable of competing for binding sites on a surface of the non-cancerous tissue, provided that the administration is carried out after a waiting period that follows administration of a compound including a radionuclide to the patient, the compound having affinity for both a cancerous tissue and the non-cancerous tissue, and, further provided that the binding sites have an affinity for both the agent and the compound.
    Type: Grant
    Filed: April 28, 2020
    Date of Patent: November 9, 2021
    Assignee: Molecular Insight Pharmaceuticals, Inc.
    Inventors: John W. Babich, Shawn Hillier, John Joyal
  • Patent number: 11167050
    Abstract: Described are: [1] a compound or the like represented by the formula (1); [2] a compound or the like having a target molecule recognition element bound to the compound or the like described in the above [1]; and [3] a metal complex compound or the like having a metal selected from the group consisting of a radioactive metal and a radioactive atom-labeled metal, and the compound or the like described in the above [1] or [2] coordinated to the metal. Also described are uses of the compound or the like described in the above [1] or [2] or the metal complex compound or the like described in the above [3] in a radioactive drug, a radiotherapeutic agent or a radioactive diagnostic imaging agent.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: November 9, 2021
    Assignee: NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
    Inventors: Yasushi Arano, Tomoya Uehara, Hiroyuki Suzuki
  • Patent number: 11167051
    Abstract: Certain exemplary embodiments of the present disclosure can provide an apparatus and method for generating at least one radiation can be provided. The exemplary apparatus and/or method can selectively kill and/or affect at least one virus. For example, a radiation source first arrangement can be provided which is configured to generate at least one radiation having one or more wavelengths provided in a range of about 200 nanometers (nm) to about 230 nm, and at least one second arrangement can be provided which is configured to prevent the at least one radiation from having any wavelength that is outside of the range can be provided or which can be substantially harmful to cells of the body.
    Type: Grant
    Filed: March 17, 2020
    Date of Patent: November 9, 2021
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Gerhard Randers-Pehrson, David Jonathan Brenner, Alan Bigelow
  • Patent number: 11167052
    Abstract: A sanitizing apparatus sanitizes headsets or eyeglasses between uses by patients. The apparatus includes a UV-C lamp that generates UV-C light at a proper frequency and intensity during a time period of sufficient duration to kill bacterial and viral infectants on surfaces of the headsets or eyeglass frames that may come in contact with a patient's skin. The apparatus may also be used for sanitizing bone vibrators, otoacoustic emissions testing equipment, headsets used in impedance testing, insert earphones, and response buttons that are commonly used in audiometric testing. The apparatus can also be used in communication situations in which headsets are utilized with microphones, such as in call centers.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: November 9, 2021
    Inventor: Daniel R. Schumaier
  • Patent number: 11167053
    Abstract: A system and method for an antivirus and radiation detection system configured to protect a wearer is provided. The system includes a personal protective equipment for preventing respiratory infection that includes a body configured to cover a nose and mouth of the user the body including at least one filter element disposed in the body that allows air to pass through the filter element from a first side of the body to a second side of the body; the filter element having a filter media; an ultraviolet light element disposed in the filter element that provides ultraviolet light into the filter media; and a pulsing laser element disposed in the filter element.
    Type: Grant
    Filed: March 19, 2021
    Date of Patent: November 9, 2021
    Inventor: Mark Laty
  • Patent number: 11167054
    Abstract: Activated hydrogen peroxide disinfecting compositions are provided especially for low-foaming applications. A concentrate for dilution by an end-user is provided, which includes a hydrogen peroxide source, a non-surfactant organic sulfonic acid or salt thereof, a non-ionic surfactant, and an optional organic acid. Also provided is a ready-to-use hydrogen peroxide, disinfectant solution including a biocidal amount of hydrogen peroxide, a non-surfactant organic sulfonic acid or salt thereof, a non-ionic surfactant, water as solvent and an optional organic acid. An end-user can disinfect a surface of microorganisms by contacting the surface with the disinfecting composition for an amount of time effective to kill a majority of the microbes located on the surface.
    Type: Grant
    Filed: April 16, 2020
    Date of Patent: November 9, 2021
    Assignee: LONZA, LLC
    Inventors: Deqing Lei, Philip Gerdon Sweeny
  • Patent number: 11167055
    Abstract: The present invention is directed to methods, compositions and articles comprising olfactory-active compositions. An article of the present invention comprises a structural component and an olfactory-active composition. The article may control the release, release rate or absorption of the olfactory-active composition. The article may be of various shapes and sizes. A method of use of an article comprises providing fragrance to an environment.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: November 9, 2021
    Assignee: ENVIROSCENT, INC.
    Inventors: Nicholas D. McKay, Jeffrey S. Sherwood, Jeffery S. Hsieh, Pedro Antonio Rodriguez
  • Patent number: 11167056
    Abstract: Air disinfection device using ozone for killing bacteria and viruses with ozone recombination unit, comprising a housing (10), a fan (20), an ozone generator (50) included in the housing (10) and arranged in a separate box (30), the ozone generator (50) is electrically driven by a supply unit (41) connecting a high voltage to the ozone generator (50) to excite corona discharge, wherein a germicidal lamp (40) light is arranged in the box (30), and both the germicidal lamp (40) and the ozone generator (50) are driven by electric pulses having a frequency over 10 KHz, and an ozone recombination unit (60) is arranged behind the box (30) across the airflow passage to neutralize ozone included in the air flow that comprises at least two windings (63, 64) each having at least one surface comprised of respective spaced wires positioned across the airflow path and connected to a supply unit (61) coupling a pulsated high voltage with a repetition frequency over 10 kHz between the windings (63, 64).
    Type: Grant
    Filed: March 4, 2021
    Date of Patent: November 9, 2021
    Inventor: Tibor Gabor Groholy
  • Patent number: 11167057
    Abstract: The present invention provides an air purifier that purifies, disinfect and decontaminate convention air flow by using UV rays. Because the UV rays emitted by the UV light sources are contained within the air purifier, use of the air purifier is safe in that a nearby person can avoid exposure to hazardous UV radiation. Adjustment of operating conditions, such as the UV intensity and wavelength and air speed, is programmable via a remote controller, a smart switch, a smart device, a wireless communication device, a smart home control appliance, a sensing device, and/or a built-in module, which renders the air purifier a smart appliance that may automatically and optimally suits to a user's need based on the user's habit and other physical parameters. Installation and removal of the air purifier, as well as cleaning and replacement of any part thereof, are simple and convenient, as a result of the clever design.
    Type: Grant
    Filed: June 24, 2021
    Date of Patent: November 9, 2021
    Assignee: OLYMPIA LIGHTING, INC.
    Inventor: Ram Shalvi
  • Patent number: 11167058
    Abstract: Compositions comprising clay minerals and methods for their use in promoting hemostasis are provided. The compositions comprise clay minerals such as bentonite, and facilitate blood clotting when applied to a hemorrhaging wound. Electrospun or electrosprayed materials (e.g. bandages, micron beads, etc.) which include clay minerals, and methods for the treatment of acute hemorrhage, are also provided.
    Type: Grant
    Filed: February 15, 2006
    Date of Patent: November 9, 2021
    Assignee: VIRGINIA COMMONWEALTH UNIVERSITY
    Inventors: Robert F. Diegelmann, Kevin R. Ward, Marcus E. Carr, Gary Lee Bowlin
  • Patent number: 11167059
    Abstract: Wound dressings and wound inserts comprising substantially dry reactive agents, methods of forming wound inserts comprising dry reactive agents, and wound-treatment methods.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: November 9, 2021
    Assignee: KCI LICENSING, INC.
    Inventors: Kz Hong, Shannon C. Ingram, Dmitry Zimnitsky, Justin Alexander Long, Richard Marvin Kazala, Jr., Hugo Ramirez
  • Patent number: 11167060
    Abstract: To provide a method for producing a calcium carbonate block for medical use which is useful as a bone substitute or a bone substitute raw material needed in medical care, which is a method for producing a calcium carbonate block that satisfies the following desired properties: 1) the calcium carbonate block has excellent mechanical strength; 2) the calcium carbonate block can be produced by a simplified production method; 3) the calcium carbonate block contains no impurity; and 4) the calcium carbonate block has high reactivity. A method for producing a calcium carbonate block, comprising a step of shaping a water-containing calcium hydroxide block and a carbonation step of immersing the calcium hydroxide block in a carbonate ion-containing aqueous solution.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: November 9, 2021
    Assignee: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION
    Inventors: Kunio Ishikawa, Kanji Tsuru, Akira Tsuchiya, Yuki Sugiura, Noriko Tanaka, Yasuharu Nakashima
  • Patent number: 11167061
    Abstract: A tympanic construct fabricated from at least one amniotic membrane, at least one chorionic membrane, or at least one amniotic membrane and at least one chorionic membrane obtained from human birth tissue is provided. Methods of preparing a tympanic construct, methods of repairing tympanic membrane defects and surgical sites, as well as kits for the same are also provided.
    Type: Grant
    Filed: February 6, 2018
    Date of Patent: November 9, 2021
    Assignee: BioDLogics LLC
    Inventor: Timothy R. Brahm
  • Patent number: 11167062
    Abstract: Provided herein are scaffold biomaterials comprising a decellularised plant or fungal tissue from which cellular materials and nucleic acids of the tissue are removed, the decellularised plant or fungal tissue comprising a cellulose- or chitin-based 3-dimensional porous structure. Methods for preparing such scaffold biomaterials, as well as uses thereof as an implantable scaffold for supporting animal cell growth, for promoting tissue regeneration, for promoting angiogenesis, for a tissue replacement procedure, and/or as a structural implant for cosmetic surgery are also provided. Therapeutic treatment and/or cosmetic methods employing such scaffolds are additionally described.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: November 9, 2021
    Assignee: UNIVERSITY OF OTTAWA
    Inventors: Andrew Edward Pelling, Charles Michel Cuerrier, Daniel J. Modulevsky, Ryan Joseph Hickey
  • Patent number: 11167063
    Abstract: The present disclosure is directed toward composite materials comprising high aspect ratio habits of drug crystals which can be partially or fully extending into a substrate, and additionally, can be projecting from a substrate at an angle of about 20° to about 90°. The present disclosure is directed toward medical devices, such as medical balloons, comprising said composite and methods of using and making the same. The described composite can be used for the local treatment of vascular disease. The present disclosure is also directed toward paclitaxel crystals with a hollow acicular habit.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: November 9, 2021
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: Robert L. Cleek, Edward H. Cully, Paul D. Drumheller, Mei Li, Peter D. Traylor
  • Patent number: 11167064
    Abstract: Hygienic Hydrophilic coatings, hydrophilic coating formulations and wetting fluids that include an anti-infective agent.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: November 9, 2021
    Assignee: Hollister Incorporated
    Inventors: David J. Farrell, John P. O'Mahony, James J. Fitzpatrick, Padraig M. O'Flynn, Paul C. Fletter, William K. Arnold, John T. Clarke, Adam J. Foley, Malford E. Cullum
  • Patent number: 11167065
    Abstract: The present invention relates to a method for coating catheter balloons with the pharmacological agent paclitaxel and the biological and biodegradable polymer composition shellac and optionally further components. Moreover the present invention relates to paclitaxel and shellac coated catheter balloons obtained according to the coating methods disclosed herein as well as the use of such coated catheter balloons for the short time release of the pharmaceutically active agent paclitaxel for prophylaxis and treatment of restenosis especially restenosis caused by angioplasty. The coated catheter balloons can be used alone or in combination with a coated or uncoated stent crimped on the catheter balloon before or after the coating with shellac and paclitaxel.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: November 9, 2021
    Assignee: EUROCOR TECH GMBH
    Inventor: Michael Orlowski
  • Patent number: 11167066
    Abstract: Drug-eluting devices and methods for the treatment of tumors of the pancreas, biliary system, gallbladder, liver, small bowel, or colon, are provided. Methods include deploying a drug-eluting device having a film which includes a mixture of a degradable polymer and a chemotherapeutic drug, wherein the film has a thickness from about 2 ?m to about 1000 ?m, into a tissue site and releasing a therapeutically effective amount of the chemotherapeutic drug from the film to treat the tumor, wherein the release of the therapeutically effective amount of the drug from the film is controlled by in vivo degradation of the polymer at the tissue site.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: November 9, 2021
    Assignees: The General Hospital Corporation, Massachusetts Institute of Technology
    Inventors: Laura Indolfi, Elazer R. Edelman, Robert S. Langer, Jeffrey W. Clark, David T. Ting, Cristina Rosa Annamaria Ferrone, Matteo Ligorio
  • Patent number: 11167067
    Abstract: The present invention relates to a breast pump (1) comprising a first pump (6) and second pump (6?), at least one expression kit (2, 2?), a valve assembly (13), and a control unit (8) for controlling the valve assembly (13) and/or the pumps (6, 6?), wherein the control unit (8) is configured to control the valve assembly (13) and/or the pumps (6, 6?) for alternate operation of the first and second pumps (6, 6?) in dependency of the operation times of the first and second pumps (6, 6?).
    Type: Grant
    Filed: February 9, 2017
    Date of Patent: November 9, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Bente De Lat, Arjan Teodor Van Wieringen, Arnold Aalders
  • Patent number: 11167068
    Abstract: An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid; a control unit (12) is configured for receiving a desired sodium mass transport at the end of the treatment session and for setting the sodium concentration value for the dialysis fluid in the dialysis supply line (8) at a set point to achieve the desired sodium mass transport at the end of the treatment session.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: November 9, 2021
    Assignee: Gambro Lundia AB
    Inventor: Anders Nilsson
  • Patent number: 11167069
    Abstract: A medicament preparation system, according to an embodiment, includes a water purification module and a medicament proportioning module. The system is configured to allow convenient and safe use in a home environment or a critical care environment as well as others affording safety, reliability, and a compact form factor.
    Type: Grant
    Filed: September 19, 2019
    Date of Patent: November 9, 2021
    Assignee: NxStage Medical, Inc.
    Inventors: Goetz Friederichs, William K. Weigel, Dennis M. Treu, Jeffrey H. Burbank, James M. Brugger, Keith David J. Wheeler, Scott W. Newell
  • Patent number: 11167070
    Abstract: The invention relates to systems and methods for recharging sorbent materials and other rechargeable dialysis components. The systems and methods include rechargers, flow paths, and related components for connecting multiple rechargers together to sharing infrastructure and resources. The rechargeable dialysis components can include zirconium phosphate, zirconium oxide, and other sorbent cartridge materials including any combination thereof or any other rechargeable component of a dialysis system. Additionally, a single-use cartridge or a multi-use cartridge can be used in the present invention.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: November 9, 2021
    Assignee: Medtronic, Inc.
    Inventor: Martin T. Gerber
  • Patent number: 11167071
    Abstract: A computer-implemented method and a computer system are disclosed. The computer system (200, 300) is suitable for detecting an operating state of a blood treatment machine (100, 201, 202, 20 . . . , 20n) or of a course of treatment in a blood treatment or a deviation from an ideal or uncomplicated operating state or a course of treatment.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: November 9, 2021
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventor: Pascal Kopperschmidt
  • Patent number: 11167072
    Abstract: A suction discharge unit of a suction discharge device includes a first unit and a second unit. The second unit controls the pressure inside the first unit. The first unit includes a storage chamber and a water sealing chamber. The water sealing chamber includes a first chamber communicating with the storage chamber, and a second chamber is sealed from the first chamber by sealing water. A negative pressure control unit is disposed in the second chamber. The negative pressure control unit includes a liquid retaining part retaining a liquid, a control member including control holes, and a support tube supporting the control member. The negative pressure control unit controls the pressure of the first chamber by causing gas to flow from the second chamber into the first chamber via the control holes and the liquid based on the pressure of the second chamber and the pressure of the first chamber.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: November 9, 2021
    Assignee: MURATA MANUFACTURING CO., LTD.
    Inventors: Kiyoshi Kurihara, Susumu Takeuchi, Kenichiro Kawamura, Hiroaki Wada
  • Patent number: 11167073
    Abstract: A system for applying reduced pressure to tissue includes a multi-lumen reduced pressure delivery tube having a proximate end, a distal end, a primary lumen extending through the conduit from the proximate end to the distal end, and an ancillary lumen extending through the conduit from the proximate end to the distal end. A vacuum pump is coupled to the proximate end of the primary lumen, and a reduced pressure adapter is coupled to the distal end of the reduced pressure delivery tube. The adapter includes channels to direct liquid away from the ancillary lumens and into the primary lumen.
    Type: Grant
    Filed: April 15, 2019
    Date of Patent: November 9, 2021
    Assignee: KCI Licensing, Inc.
    Inventors: Keith Patrick Heaton, Timothy Mark Robinson, Christopher Brian Locke
  • Patent number: 11167074
    Abstract: Systems, apparatuses, and methods for utilizing a dressing having a single manifold fluidly coupled to at least two therapy units in a negative-pressure therapy and/or instillation therapy environment as set forth herein. In one example embodiment wherein the therapy system comprises two therapy units, apparatus and methods may be utilized for alternately applying pressure or fluids to a single tissue site to more quickly remove large amounts of fluid from the tissue site.
    Type: Grant
    Filed: January 31, 2017
    Date of Patent: November 9, 2021
    Assignee: KCl Licensing, Inc.
    Inventors: Timothy Mark Robinson, Christopher Brian Locke, James A. Luckemeyer
  • Patent number: 11167075
    Abstract: In some embodiments, a negative pressure apparatus includes a negative pressure source configured to provide negative pressure via a fluid flow path to a wound dressing placed to create a seal over a wound, a pressure sensor, and a controller. The controller can be configured to operate the negative pressure source in a first mode and determine a change in pressure in the fluid flow path over a period of time based on a plurality of measurements by the pressure sensor. In response to a determination that pressure in the fluid flow path is decreasing, the controller can operate the negative pressure source in a second mode in which greater amount of negative pressure is provided than in the first mode. In response to a determination that pressure in the fluid flow path is not decreasing, the controller can provide an indication of a first leak in the seal.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: November 9, 2021
    Assignee: Smith & Nephew PLC
    Inventor: Ben Alan Askem
  • Patent number: 11167076
    Abstract: A medical device for use with an associated tube inserted into an incision formed in skin or tissue of a patient includes a dressing including an opening sized to receive and allow movement of the associated tube. A valve is operatively connected with the opening of the dressing and includes a main body; and an opening formed in a portion of the main body. The opening is sized and dimensioned to accommodate the surgical tube.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: November 9, 2021
    Assignee: EHK Medical, LLC
    Inventor: Eric A. Espinal
  • Patent number: 11167077
    Abstract: Irrigation devices, methods, and systems are disclosed. The system comprises a catheter with one or more lumens and an expandable portion. One or more pumps are used to supply a mixture of contrasting and dilating agents in an interior kidney volume and flush a portion of the mixture out of the interior kidney volume. The method comprises placing a catheter into the interior kidney volume through a ureter, occluding a portion of the ureter with a distal end of the catheter, forming an exit port through an exterior kidney surface, flowing the contrasting and dilating agents through the one or more lumens to supply the mixture in the interior kidney volume, and flushing a portion of the mixture out of the exit port.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: November 9, 2021
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Jerry Long, Timothy Harrah, Aaron Kirkemo, Brandon Craft, Elizabeth Stokley, Sebastian Koerner, Chad Schneider
  • Patent number: 11167078
    Abstract: The present invention relates to an apparatus for flow tempering medical irrigation fluids and to a method carried out with the aid of this apparatus.
    Type: Grant
    Filed: July 20, 2017
    Date of Patent: November 9, 2021
    Assignee: W.O.M. WORLD OF MEDICINE GMBH
    Inventors: Andreas Lutz, Karl-Heinz Guenter Schoenborn
  • Patent number: 11167079
    Abstract: A cartridge for delivery of a material therefrom which has a corrugated portion to allow for bending/extending to be applied to the device from which a material to be deposited can be dispensed. The bendability and extendibility allow for greater efficiency in use and application of the material into cavities, pockets, and/or crevices where one needs to deposit the material.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: November 9, 2021
    Assignee: Profounda, Inc.
    Inventors: Todd Ewen MacLaughlan, Vinit Gopal Kathardekar, Amanullah Abdulhamid Vazir
  • Patent number: 11167080
    Abstract: A medical device for the treatment and irrigation of a sinus opening is described. The device allows for single-handed operation to access, dilate and irrigate a sinus opening. The device includes a sinus guide catheter, a guiding element, a balloon dilation catheter, a balloon catheter movement mechanism and a guiding element movement mechanism. A method for treating a sinus opening and irrigating a sinus is also described.
    Type: Grant
    Filed: April 7, 2021
    Date of Patent: November 9, 2021
    Assignee: Acclarent, Inc.
    Inventors: Mina W. Chow, Thomas R. Jenkins, Arthur M. Lin, Mei Y. Pader, Jessica K. Chan, Scott O. Chamness
  • Patent number: 11167081
    Abstract: An assembly is configured to position a peristaltic tube with respect to a linear peristaltic pump drive of an infusion pump. The assembly can include a peristaltic tube, first and second tube couplers, a frame, first and second securement plates, a free-flow prevention arm, and a biasing mechanism. The frame can include a snap-fit tab configured to releasably secure the assembly to an assembly receptacle of the infusion pump. The free-flow prevention arm can be selectively movable between a free-flow preventing position and a free-flow allowing position. A latching mechanism can be ergonomically manipulable to latch the free-flow prevention arm in a free-flow allowing position, and to unlatch the free-flow prevention arm such that the biasing mechanism is able to bias the free-flow prevention arm to the free-flow preventing position.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: November 9, 2021
    Assignee: Smiths Medical ASD, Inc.
    Inventors: Grant A. Adams, James Bryan Drost, Christopher Allen Lacy, Jonathan Sanborn, Daniel L. Adamson, Harshad Borgaonkar, Sameer Pai, Sean Riley
  • Patent number: 11167082
    Abstract: A drive mechanism (100) for use with a drug container (50) in a drug pump, the drug container (50) having a barrel (58) and a plunger seal (60), including a tether, an electrical actuator (101) and a gear interface. Rotation of the gear interface is controlled by the actuator (101). A gear assembly rotationally engages with the gear interface. The gear assembly includes a main gear and a regulating mechanism. Release of the tether is metered by the gear assembly through the regulating mechanism. A piston (110, 1110, 2110) is connected to the tether and is disposed in the barrel (58) and configured to translate axially within the container. A biasing member is disposed at least partially within the barrel (58) and is retained in an energized state between the piston (110, 1110, 2110) and drive housing, wherein the release of the tether controls the free expansion of the biasing member from its energized state and the axial translation of the piston (110, 1110, 2110).
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: November 9, 2021
    Assignee: AMGEN INC.
    Inventors: Lawton Laurence, Paul F. Bente, IV, Mark A. Destefano, Ian P. Dardani, Ian B. Hanson
  • Patent number: 11167083
    Abstract: The present disclosure relates to systems and methods for controlling an MRI safe patient care/monitoring system. The system may include a an MRI safe infusion pump that contains a co-processor which acts as a central brain for all other patient care/monitoring devices in the MRI room. The co-processor is separated from the primary processor by a buffer in the infusion pump's memory, so that no actions by the co-processor can affect the primary processor. The co-processor controls the display software, alert software and alerts database. All other patient care/monitoring devices are connected to the MRI safe infusion pump in a daisy chain, so that they can share a single connection to outside the MRI room. Outside the MRI room the co-processor has access to the remote control & display, which contains the remote control GUI, and to the internet, through which it will access an external medical network, which contains an algorithm database.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: November 9, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: John Cronin, Michael D'Andrea
  • Patent number: 11167084
    Abstract: The invention relates to a control device for controlling the administration of propofol to a patient according to the preamble of claim 1 and to a method for controlling the administration of propofol to a patient according to the preamble of claim 4. With a method of this kind a bispectral index (BIS) target value is set which shall be, at least approximately, reached within a patient. A controller then computes a recommended infusion rate of propofol based on the target BIS value and further based on a measured propofol level of the patient for administering propofol to the patient.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: November 9, 2021
    Assignee: Fresenius Vial SAS
    Inventors: Alexandre Guerrini, Pauline Cottin
  • Patent number: 11167085
    Abstract: Embodiments include a syringe-based apparatus for delivering fluid, the apparatus comprising a housing having an open proximal end and a distal end defining an inner volume, a needle, an actuator mechanism coupled with the housing, the actuator mechanism comprising a syringe body and a plunger, a medicament reservoir, and a reconstitution fluid reservoir.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: November 9, 2021
    Assignee: TRUE CONCEPTS MEDICAL TECHNOLOGIES, LLC
    Inventor: Michael Hopkins
  • Patent number: 11167086
    Abstract: An autoinjector including a syringe, a driver for driving the plunger of the syringe and a stabilizing adaptor for holding the injector on the skin of a patient is provided. The stabilizing adaptor has an adhesive base with a long axis to short axis ratio of at least 1.5 to 1. The syringe is orientated with its axis at an angle of between 60 and 120 degrees to the base during operation of the autoinjector.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: November 9, 2021
    Assignee: West Pharma. Services IL, Ltd.
    Inventors: Oz Cabiri, Ran Hezkiahu
  • Patent number: 11167087
    Abstract: An apparatus includes a housing, an energy storage member, a carrier, a medicament container, and a delivery control mechanism. The housing defines a gas chamber configured to receive pressurized gas from the energy storage member to pressurize the gas chamber. The carrier has a proximal surface that defines a portion of the gas chamber. The medicament container is coupled to the carrier and has a distal end portion coupled to a delivery member. The medicament container contains a medicament and includes an elastomeric member that seals the medicament within the medicament container. The delivery control mechanism is coupled to a proximal end portion of the medicament container and includes a flow restriction member for regulating a pressure supplied by the gas chamber and entering into the medicament container that acts on the elastomeric member.
    Type: Grant
    Filed: August 7, 2020
    Date of Patent: November 9, 2021
    Assignee: kaleo, Inc.
    Inventors: Paul F. Meyers, Michael J. Roe
  • Patent number: 11167088
    Abstract: An injection device includes a container receiving receptacle configured for receiving a container for containing a medicinal product to be administered; a dispensing mechanism for causing the product in the container to be injected; and a RFID system associated with the container receiving receptacle capable of communicating bidirectionally with a RFID tag attached to the container and enabling the administration of the product only under given conditions. The RFID tag can be therefore read and written by the RFID system. The RFID system further includes an antenna arranged at least partially covering the RFID tag. The dispensing mechanism is triggered by a contact sensor when the device is pressed onto the animal's skin. The needle-free injection device is capable of communicating with external devices (PC, laptops, tablets, smartphones and the like).
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: November 9, 2021
    Assignee: HIPRA SCIENTIFIC, S.L.U.
    Inventors: Marc Font Ventura, Maria Glòria Pujol Prat, Joan Carles Pons Moll
  • Patent number: 11167089
    Abstract: Syringe for dispensing medical foam having a substantially cylindrical barrel with a nozzle at its forward end and a plunger with a substantially cylindrical shaft disposed within the barrel. A flexible annular flange is provided on the inner surface of the barrel which extends toward the nozzle to contact the shaft and form a seal between the barrel and the plunger.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: November 9, 2021
    Assignee: Provensis Limited
    Inventor: David Dakin Iorwerth Wright
  • Patent number: 11167090
    Abstract: The present invention relates to a prefilled glass container, such as a prefilled glass syringe, comprising an aqueous botulinum toxin formulation. The aqueous botulinum toxin formulation in the prefilled container is stable at low to ambient temperature for a prolonged time period. Furthermore, the present invention relates to a kit comprising the botulinum toxin prefilled container, and to the use of the botulinum toxin prefilled container in therapeutic and cosmetic applications.
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: November 9, 2021
    Assignee: Merz Pharma GmbH & Co. KGaA
    Inventor: Markus Vogt