Abstract: A precision syringe includes a syringe barrel and plunger that has a base, an internal portion, and an external portion. The internal portion of the plunger extends longitudinally into the syringe barrel. The internal portion has a first end coupled to the base and a second end that is configured to push fluid out of and/or suction fluid into the syringe barrel. The external portion extends longitudinally along an outer surface of the syringe barrel. The external portion has a first end coupled to the base and a second end that is configured to receive an applied force that causes the plunger to move relative to the syringe barrel so that the second end of the internal portion is actuated through a portion of the syringe barrel (e.g., to dispense fluid from or suction fluid into the syringe barrel).

Abstract: Drug delivery device adapted to expel a set dose, comprising an expelling mechanism with a drive spring, a dose setting mechanism with first and second dose setting ratchet parts, a bias spring as well as control means. The control means is adapted to rotate the second ratchet part in a first direction to thereby set a dose when rotating the dose setting member in the first direction, and move the ratchet parts axially out of engagement with each other when the dose setting member is rotated in the opposite direction. When the first and second ratchet parts have been axially disengaged, the drive spring will rotate the second ratchet part in the second direction to thereby reduce the set dose, the bias spring moving the ratchet parts axially into engagement with each other again, this resulting in the set dose being reduced corresponding to one tooth of the ratchet mechanism.

Abstract: An assembly for a drug delivery device comprises a housing, a dose member which is displaceable in a proximal direction with respect to the housing for setting of a dose of a drug, a clutch member which is displaced in the proximal direction with respect to the housing when setting the dose, and a stop member configured to define a clutch stop position. The clutch member and the dose member are configured to mechanically cooperate with one another when the clutch member is in the clutch stop position, thereby preventing further displacement of the dose member in the proximal direction with respect to the housing during setting of the dose.

Abstract: The present invention relates to a medicament delivery device comprising a generally tubular distal housing part (10; 110) having opposite proximal and distal ends, wherein third mechanically coded interface means (11; 111) are arranged on its proximal end; a generally tubular proximal housing (20; 120) part having opposite proximal and distal ends and being releasibly connected to said distal housing part, wherein with fourth mechanically coded interface means (22; 122) are arranged on its distal end; a medicament container having a slidable stopper, wherein said container is arranged to be positioned within said proximal housing part; a plunger rod (60; 160) arranged within said distal housing; drive means arranged within said distal housing and being operably connected to said plunger rod for driving said plunger rod and thereby said stopper towards the proximal end of the device; wherein said device further comprises an interface member (50; 150) comprising first (51; 151) and second (52; 152) mechanicall

Abstract: Disclosed embodiments include flexible tube assemblies, flexible needle assemblies, systems, methods of fabricating a flexible tube, and methods of fabricating a flexible needle.

Abstract: A filter cartridge for surgical gas delivery systems includes a filter housing configured to be seated in a filter cartridge interface of a surgical gas delivery system, with a plurality of flow paths defined through the filter housing including at least one evacuation/return flow path and at least one insufflation/sensing flow path. A humidity filter element is included in the evacuation/return flow path for removing humidity from an evacuation/return lumen of a tube set. The humidity filter element can include a sintered polymer material configured to provide tortuous flow paths therethrough to condense humidity out of a flow through the humidity filter element.

Abstract: A flap (20) for an inhalation actuated mechanism (18) of a powder inhaler (1) comprises a base member (29), a skirt structure (24) projecting from a surface of the base member (29), and a coupling portion (21) to be coupled to a resilient member (40?) of the inhalation actuated mechanism (18).

Abstract: A modular electronic cigarette which can be assembled into different shapes and configurations includes at least one atomization module and at least one battery module, the at least one atomization module and at least one battery module being detachably assembled together by means of magnetic connection, snap-fit, USB connection, or accessory to obtain various combination shapes of the electronic cigarette. Threaded connections between components are not required. The electronic cigarette can satisfy requirements of the user for simple and diverse combinations of components, thus increasing the user experience.

Abstract: A method for controlling a vaporizer device may include determining a first temperature, vaporizing an inhalable substance at the first temperature, raising the first temperature by a temperature quantity, wherein a second temperature is a sum of the temperature quantity and the first temperature; and vaporizing the inhalable substance at the second temperature, wherein the temperature quantity is less than 3° C.

Abstract: An anesthesia ventilator, for the automated ventilation of a patient, includes an expiratory port and an inspiratory port for connecting a ventilation tube facing the patient for a breathing gas, a breathing gas delivery unit, at least one breathing gas sensor for detecting an anesthetic gas concentration, at least one pressure sensor for detecting a pressure of the breathing gas, as well as at least one computer. The computer is configured to actuate the breathing gas delivery unit as a function of the detected pressure of a preset desired pressure value. The computer is further configured to perform an adaptation of the desired pressure value as a function of the detected anesthetic gas concentration.

Abstract: An interfacing structure for a mask system includes a cushion component adapted to contact the patient's face in use and a cushion-to-frame component provided to the cushion component. The cushion-to-frame component is structured to secure the cushion component to a mask frame of the mask system. The cushion-to-frame component includes a cushion side adapted to interface with the cushion component and a frame side adapted to interface with the mask frame. The cushion side includes a platform to engage and support the cushion component. The platform provides an engagement surface to engage the cushion component and inner and outer flanges provided to opposing ends of the platform to guide, support and/or retain the cushion component on the platform.

Abstract: The present technology is directed to a respiratory pressure therapy system, that includes a plenum chamber pressurisable to a therapeutic pressure above ambient air pressure, a seal-forming structure to form a seal with an entrance to the patients airways to maintain said therapeutic pressure in the plenum chamber throughout the patients respiratory cycle in use, a positioning and stabilising structure constructed and arranged to provide an elastic force to hold the seal-forming structure in a therapeutically effective position on the patients head, a blower configured to generate the flow of air and pressurise the plenum chamber to the therapeutic pressure. the blower having a motor, the blower being connected to the plenum chamber such that the blower is suspended from the patients head and the axis of rotation of the motor is perpendicular to the patients sagittal plane, and a power supply configured to provide electrical power to the blower.

Abstract: A patient interface includes a frame including a textile material and a seal-forming structure provided to the frame. The seal-forming structure includes a foam material and/or a foam and textile material configured and arranged to form a seal with the patient's nose and/or mouth.

Abstract: Respiratory masks made of thermoformed EVA foam are provided. A mask can include a seal that contacts a user's face in use and a housing permanently joined to the seal. Both the seal and housing can be made of EVA foam. The seal and housing can be made of EVA foam having different densities. The mask can further include a frame removably or permanently coupled the housing. Headgear can be coupled to the frame and can couple the mask to the user's face in use.

Abstract: A method and apparatus for stimulating neural activity in the brain of a user of an apparatus with a display screen by causing at least one portion of the display screen to flicker in a controlled manner and utilizing the apparatus to measure an effect on a user exposed to the flicker for a time.

Abstract: A catheter has an elongate shaft with a longitudinal drainage bore for conveying fluid along the shaft. An elongate, tapered tip portion extends from an end of the shaft, the tip portion having a distal end furthest from the shaft, and a drainage aperture is provided in the tip portion, being in fluid communication with the bore. An inflatable balloon element is attached to the tip portion. The balloon element is configured such that when it is fully inflated, at least a portion of the balloon element extends around the distal end of the tip portion and extends along the tip portion to a point on an opposite side of the drainage aperture to the distal end, a surface of the balloon element including a depression providing a passageway in fluid communication with the drainage aperture.

Abstract: Embodiments provide a urinary catheter assembly comprising an outer package of gas-impermeable material and an intermittent urinary catheter arranged inside the outer package. The catheter comprises a proximal insertion end, a distal connection end, and a connector at the distal end. The connector defines a distal opening. The catheter assembly further comprises a sleeve of liquid-impermeable material configured to define at least part of a liquid tight enclosure. The enclosure encloses the insertable part of the catheter. The enclosure is closed by a first closure in the proximal end and a second closure in the distal end. The second closure is configured to be opened as the outer package is opened and the first closure is configured to be opened as the catheter and sleeve is removed from the outer package.

Abstract: A medicine injection catheter includes: a catheter main body formed with a medicine supply lumen; a tubular body connected to the distal end of the catheter main body and having a lumen communicating with the medicine supply lumen; an injection needle connected to the tubular body; a tubular cover member that accommodates the tubular body and that is configured to be advanced and retracted in the axial direction of the catheter main body between a first position where a distal end of the injection needle is accommodated in the tubular cover and a second position where the distal end of the injection needle protrudes forward from the inside space; a closing member to close and open the lumen of the tubular body, a motion conversion mechanism which converts advancing/retracting motion of the cover member into movement of the closing member to close the lumen of the tubular body.

Abstract: A lavage catheter for the treatment of a maxillary sinus is described. The catheter comprises a proximal portion and a distal portion. The distal portion comprises an irrigation tip. The irrigation tip has a tip opening through which fluid may be delivered by one handed operation of the catheter. A method for lavaging the maxillary sinus includes inserting the lavage catheter into a patient's anatomy and advancing the irrigation tip into the maxillary sinus using one hand.

Abstract: The technical objective of the present disclosure is to provide a steerable catheter enabling a lumen tip to approach an affected area only with an endoscope inserted together, without the aid of a C-type gantry based tomography apparatus. To this end, the steerable catheter according to the present disclosure includes: a housing; a lumen shaft; upper left, lower left, upper right and lower right wire parts; upper left, lower left, upper right and lower right stoppers; and a steering part for upwardly steering the terminal end of the lumen shaft by pulling the upper left and upper right wire parts, downwardly steering the terminal end of the lumen shaft by pulling the lower left and lower right wire parts, leftwardly steering the terminal end of the lumen shaft by pulling the upper left or lower left wire part, and rightwardly steering the terminal end of the lumen shaft by pulling the upper right or lower right wire part.

Abstract: Medical devices and methods for delivering fluid. The medical devices include one or more needles for delivering fluid. The methods may include expanding an expandable member such as an inflatable member to expand an expandable scaffold outward toward a lumen wall.

Abstract: A catheter protection device and method for securing a catheter to a patient's body to prevent the unauthorized and possibly traumatic removal of a catheter. The device is thin, breathable and not easily removed by an agitated or mentally incompetent patient. The device is constructed of a base, adhesives, and a sleeve. The edges of the base each contain a section of adhesive wherein mid-portion of the base remains uncovered by adhesive. The open sleeve is permanently attached to an edge of the base. Once a catheter has been placed in an open sleeve, the sleeve will be folded such that the rear portion of the sleeve attached to the nearest edge of the base creating a closed sleeve surrounding the catheter. The catheter protection device may be placed against a patient's body with the adhesive edges of the base and an adhesive covered catheter sleeve adjacent to a patient.

Abstract: A two-piece catheter securement system has a fixation pad with an adhesive undersurface and an antimicrobial flap. On an upper surface of the pad are cooperative first attachment members. An upper capture and retention shell has an outer shell wall. The first and second ends of the shell may have a plurality of slots for capturing and retaining administration and catheter tubing. The shell has an inner shell ceiling having a plurality of spaced apart second attachment members thereon. The first and second attachment members are aligned to cooperatively engage when the shell is urged into releasable engagement with the pad with the slots capturing and retaining the tubes.

Abstract: A set for peripheral nerve blocking, including a rigid cannula, an outer catheter sleeve which can be slid over the cannula, where the distal tip of the cannula protrudes over the distal end of the catheter sleeve, an inner catheter which can be inserted through the catheter sleeve after removal of the cannula from the catheter sleeve and which has an outlet opening at the distal end, and a first connector piece at the proximal end of the catheter sleeve, where the inner catheter has a second connector piece complementary to the first connector piece, and the inner catheter can be fixed in an axial position by connecting the first connector piece and the second connector piece in the catheter sleeve, in which axial position the distal end of the inner catheter protrudes from the distal end of the catheter sleeve with a pre-defined length which has the outlet opening.

Abstract: Conventionally, a coil formed in an irregular shape is used on a distal end side of the coil of a guide wire or a distal joining section is used on the tip of the guide wire to shorten a length in a longitudinal direction of a rigid joint portion for improving the passing performance to the occluded lesion. However, it is not enough especially in the completely occluded lesion. Thus, it is an important technical problem to improve both the passing performance and safety. An outer coil having a coil inclined portion and a distal joining section connected with the coil inclined portion are provided on a distal end portion of the guide wire. In the coil inclined portion, each one turn of a coil wire is continuously inclined in a longitudinal direction. Thus, both the passing performance and safety can be remarkably improved especially in the completely occluded lesion.

Abstract: An apparatus for dilating an upper esophageal sphincter. The apparatus includes an elongated expandable member having a cross-section shaped to support a natural shape of an upper esophageal sphincter. A catheter extends from the elongated inflatable member.

Abstract: Implantable physiological shunt systems and related fluid flow control devices and accessories for use therewith. Devices, systems and methods relating to implantable medical fluid flow control devices, rotors and magnets with increased resistance to inadvertent setting changes. Devices, systems and methods relating implantable medical fluid flow control devices, rotors and magnets which provide improved magnetic coupling to fluid flow control device accessories such as adjustment tools.

Abstract: In embodiments, the sunblock lotion spray booth comprises a booth, a plurality of spray columns, a plurality of canisters, a pump, a ventilator, and one or more payment receiving devices. The booth may be adapted to spray one or more tanning products onto a user via the plurality of spray columns located within the booth once a payment receiving device and an activation button have been activated. As non-limiting examples, the one or more tanning products may be sunblock lotions having different SPF values, bronzers, or combinations thereof. One or more of the plurality of spray columns may be height-adjustable. The pump may move the tanning products from the plurality of canisters to a plurality of nozzles located on the spray columns via tubing within the walls of the booth. The ventilator may circulate air within the booth.

Abstract: The purpose of the present application is to provide a microneedle patch applicator and a microneedle patch applicator housing, whereby perpendicular penetration properties of the needle into skin are enhanced. A microneedle patch applicator housing has a flat peripheral base part configured from a single sheet or film, and a protruding part which is surrounded by the peripheral base part and bulges perpendicularly upward toward a top surface from a bottom surface with respect to the peripheral base part. A bottom-surface portion of the protruding part constitutes part of a microneedle patch support surface. The protruding part is provided with a plurality of recessed fold parts, and the recessed fold parts have recess bottoms oriented in the direction away from a center part of the protruding part.

Abstract: A medical device includes: a first member including: a body portion, and an anchor, wherein a resin material of the anchor is different from a resin material of the body portion, and wherein the anchor is interlinked to the body portion; and a second member including a connecting portion that is connected to the anchor, wherein a resin material of the second member is the same as the resin material of the anchor.

Abstract: The present invention provides an intravascular blood pump comprising a housing region that may be expandable, wherein the housing region comprises a series of troughs extending along at least a portion of the length of the housing region, wherein the integrated lead trough(s) may be defined by or within the housing region and wherein each adjacent pair of troughs are separated by an insulated spacing gap and may be covered to form insulated conduits. The integrated lead trough(s) may be configured to receive one or more electrical leads therein.

Abstract: An implant system for restoring and improving physiological intracardiac flow in a human heart is provided including a force transducting, structurally stabilizing, and functionally assisting ventricular inflatable cardiac implant within a human heart for restoring and improving physiologic intracardiac flow, restoring the ventricular vortex, preventing atrioventricular pressure gradient loss, mitigating valvular regurgitation, and utilizing native energy and force, via force transduction, to restore geometric elliptical proportion and function to the atria, the ventricles and ventricular walls, and the valvular apparatus itself.

Abstract: Controllers and methods for heart treatments are disclosed herein. The controller can include a communication module that can send and receive data from heart therapy devices. The controller can include memory including stored instruction. The controller can include a processor. The processor can receive a signal of an impending electrical treatment at a processor. The processor can determine a current operating parameter of a blood pump communicatingly coupled with the processor. The processor can determine an adjustment to the operating parameter of the blood pump to affect an impedance of heart tissue to be affected by the impending electrical treatment. The processor can control the blood pump according to the adjustment to the operating parameter of the blood pump.

Abstract: The catheter device comprises a motor at the proximal end of the catheter device and a drive shaft, extending from the proximal end section to the distal end section of the catheter device, for driving a rotating element located at the distal end of the catheter device. The catheter device also comprises a hose-like catheter body which encompasses the drive shaft and extends from the proximal end section to the distal end section. At the proximal end of the catheter device, the drive shaft is connected to a motor by a clutch. The clutch is a magnetic clutch with a proximal and a distal magnet unit. The proximal magnet unit is connected to the motor and the distal magnet unit to the drive shaft. The distal magnet unit is mounted fluid-tight in a clutch housing. The proximal end of the catheter body makes a fluid-tight connection with the clutch housing.

Abstract: Described herein are treatment tip apparatuses (e.g., devices, systems, etc.) including one, or more preferably a plurality, of electrodes that are protected by an electrode partition, such as an electrode housing (which may be retractable) until pressed against the tissue for deployment of the electrodes and delivery of a therapeutic treatment. In particular, these apparatuses may include a plurality of treatment electrodes (e.g., needle electrodes) and be configured for the delivery of nanosecond pulsed electric fields.

Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.

Abstract: Disclosed is a system for stimulation of a subject. The stimulation may be to provide therapy to treat the subject. Stimulation may be of selected muscle groups and/or portions.

Abstract: An electrical stimulation lead includes terminals disposed along the proximal portion of the electrical stimulation lead; segmented electrodes disposed along the distal portion of the electrical stimulation lead; conductors electrically coupling the terminals to the electrodes; and an electrode carrier with divider segments extending from shoulder segments and disposed between, and separating, at least two of the segmented electrodes. The electrical stimulation lead can be formed by disposing electrode strips on an electrode carrier, each of the electrode strips comprising a plurality of pre-electrodes and at least one connection region in an alternating, longitudinal arrangement with one of the at least one connection region disposed between each adjacent pair of the pre-electrodes of the electrode strip; and removing each of the connection region(s) to separate the pre-electrodes into segmented electrodes.

Abstract: Applying therapeutic neural stimuli involves monitoring for at least one of sensory input and movement of a user. In response to detection of sensory input or user movement, an increased stimulus dosage is delivered within a period of time corresponding to a duration of time for which the detected sensory input or user movement gives rise to masking, the increased stimulus dosage being configured to give rise to increased neural recruitment.

Abstract: A shield member is placed within a polymer flexible carrier in between a manipulation member used to aid implant of a nerve cuff and the nerve to avoid touching the nerve surface with the manipulation member because the texture or material of the flexible member typically causes more foreign body reaction or other biologic reaction from the nerve and surrounding tissues than the polymer of the flexible carrier itself.

Abstract: An example device for repairing a tissue is described herein. The device can include a flexible carrier layer, and a support member including a plurality of micro-protrusions extending therefrom. The support member can be at least partially integrated with the flexible carrier layer. Additionally, the flexible carrier layer can be configured to cover at least a portion of the tissue, and the micro-protrusions can be configured to mechanically interface with the tissue.

Abstract: A system to deliver current to an area of interest of a subject is described that includes a power source, a controller electrically coupled to the power source, at least one first electrode electrically coupled to the controller, and at least one second electrode electrically coupled to one of the power source and the controller, with the area of interest positioned between the at least one first electrode and the at least one second electrode. A method of stimulating at least one of bone growth, tissue healing and pain control within an area of interest of a patient is described that includes inserting first and second electrode spaced at a predetermined distance, and further includes directing an electric current between the first and second electrodes so that at least a portion of the electric current passes through the area of interest positioned between the first electrode and the second electrode.

Abstract: An intratumoral modulation therapy (IMT) method for the treatment of nervous system and systemic tumor in a patient which includes: (a) chronically implanting an electrode adjacent to or in the tumor of the patient or in a residual tumor bed, the electrode having electrical leads connected thereto; and (b) generating electric stimulation and applying the electric stimulation through the electrical leads to the electrode adjacent to or within the tumor. A method of transferring genetic material to a tumor cell which includes: (a) positioning an electrode adjacent to the tumor cell, the electrode having electrical leads connected thereto; (b) generating electric stimulation and applying the electric stimulation through the electrical leads to the electrode adjacent the cancer cell; and (c) delivering the genetic material to the tumor cell treated with the continuous alternating electric stimulation.

Abstract: A system for providing biphasic stimulation is disclosed. The system includes an electrode, an antenna coupled to a transmitter, a capacitor, a power supply, a backscatter load selectively coupled to the antenna via a switching device, a plurality of switches, and a controller configured to control the switching device to output, by the antenna, an acknowledgement signal to the transmitter responsive to receiving the power. The controller is further configured to control the plurality of switches to electrically couple a first plate of the capacitor to the electrode to provide a first nerve stimulation signal having a first polarity, and electrically couple a second plate of the capacitor to the electrode to provide a second nerve stimulation signal having a second polarity opposite the first polarity. The system further includes a housing encapsulating the antenna, the capacitor, the power supply, the backscatter load, the switches, and the controller.

Abstract: An apparatus is described comprising electrodes (22) configured to be placed upon a portion of a body of a subject, and a user interface device (26). A computer processor (24) applies a neuromodulation treatment to the subject, by driving electrical pulses into the portion of the subject's body via the electrodes, and generates an output on the user interface device that indicates to the subject a physiological effect that the neuromodulation treatment has upon the subject's body.

Abstract: The invention relates to a device (10) and to a method for electric stimulation. Said device comprises a stimulator (12) which comprises a multi-channel electrode arrangement with several stimulation electrodes (E1-E12). Said device also comprises a processor (18) which determines the pulse rate and the pulse amplitude for each stimulation electrode (E1-E12), and which controls the electrode arrangement for releasing stimulation impulses of the determined pulse rate and pulse amplitude. Said processor (18) determines the pulse rate for each stimulation electrode (E1-E12) dependent on the position in the cochlea. The invention also relates to a computer program product by means of which a data processing system determines the pulse rate for each stimulation electrode (E1-E12) dependent on the actual position thereof.

Abstract: This document discusses, among other things, systems and methods for robotically assisted implantation of an implant in a patient. A system includes an external positioning unit configured to engage an elongate member of the implant, and a control console communicatively coupled to the external positioning unit. The control console may have a user interface that enables a user to input motion control instructions. The control console may generate a motion control signal, according to a specific motion control instruction, to control the external positioning unit to propel the implant into a target implant site. The system may be used to robotically control the delivery and positing of a cochlear implant during a hearing-preservation cochlear implant surgery.

Abstract: A method of treating Alzheimer's Disease and/or Multiple Sclerosis and/or Minimally Conscious State and/or Mood Disorders and/or vascular brain disorders where there is small vessel compromise in a subject in need thereof, comprising applying a neuromodulation signal to the 1PAG or v1PAG of the subject.

Abstract: Apparatus and methods for managing pain uses a single composite modulation/stimulation signal with variable characteristics to achieve the same results as separate varying electromagnetic signals, including spinal cord stimulation or peripheral nerve stimulation.

Abstract: Disclosed is a system for stimulation of a subject. The stimulation may be to provide therapy to treat the subject. Stimulation may be of selected muscle groups and/or portions.