Abstract: The present invention relates to a conical contact type ophthalmic digital microscope, and more particularly, to a conical contact type ophthalmic digital microscope allowing observation of a magnified eyeball while being placed above a cornea of a patient. The corneal contact type ophthalmic digital microscope according to the present invention includes a housing, an objective lens part installed below the housing and configured to come in contact with a cornea of an eyeball, an image sensor part installed in the housing and configured to capture the eyeball visible through the objective lens part and generate an eyeball image, a position adjuster configured to change a position of the image sensor part, and a control part configured to control operations of the image sensor part and the position adjuster and output the eyeball image through a display provided outside the housing.

Abstract: A device for simply determining maximum permissible exposure time (MPE) of retina is disclosed, which principally comprises a light receiving unit and a core processor that is provided with a color temperature determining unit, a luminous flux determining unit and a calculating unit therein. The color temperature determining unit and the luminous flux determining unit are configured for completing a color temperature determination and a luminous flux determination of a light provided by a light source, respectively. The calculating unit is configured for calculating a maximum permissible exposure time (MPE) of retina of the light source based on a use distance and a color temperature and a luminous flux of the light. By using this device, generic users are facilitated to achieve the calculation of any one kind of light's MPE by themselves, without needing to using any spectrometer.

Abstract: Disclosed herein are methods and apparatus for making a determination about an eye in ambient lighting conditions comprising detecting ambient light reflected out of an eye of a subject from a retina of the eye of the subject and making a determination about the eye of the subject based upon the reflected ambient light.

Abstract: The invention relates to a method for performing a movement correction when measuring a human eye, in which the eye is scanned by a measurement beam in order to obtain a set of position values of an eye structure. Scanning extends over a measurement time interval, wherein the position values are each provided with a timestamp within the measurement time interval. A surface shape and a displacement function are determined, with the displacement function representing a movement pattern during the measurement time interval, and the surface shape and the displacement function being determined in such a way that the position values are approximated by the surface shape when the surface shape is moved according to the displacement function. Moreover, the invention relates to an associated measurement system.

Abstract: Embodiments of the present invention provide a computer-implemented method of determining a scattering spectrum of an eye. The method comprises receiving data from a detector indicative of a reflected wave of radiation reflected from the retina, wherein the reflected wave of radiation is formed by an incident wave of masked radiation directed towards a retina of the eye, such that at least one region masked from the incident wave is present on the retina, determining a first back scattering spectrum indicative of light scattered from an optical media of the eye in dependence on a portion of the reflected wave of radiation corresponding to the at least one masked region, determining a second back scattering spectrum indicative of light scattered from a neural retina of the eye in dependence on retinal structure information representative of neural retinal structure, and determining the scattering spectrum of the eye in dependence on the first back scattering spectrum and the second back scattering spectrum.

Abstract: Various embodiments for eye imaging, screening, diagnosis, and monitoring are provided. Some embodiments comprise systems for retinal imaging capable of capturing multiple high resolution images using multiple quick succession flashes. The images can be combined to provide for a complete image of the retina of a target FOV without corneal reflections. In some embodiments, a system for retinal imaging can utilize an optical design pupil layout that allocates a large area for the path of imaging rays on the eye pupil by using a narrow buffer area. In other embodiments, a system for retinal imaging can comprise a main device, including an imaging and sensing device, and a robotic system, including an eye tracker and/or sensors, wherein the robotic system is capable of automatically aligning the main device and selecting an optimal imaging mode by detecting a pupil size of an eye and is combined with an AI analysis tool.

Abstract: The present invention relates to systems for low-energy (e.g., 1.0 nJ-7.0 nJ) photoacoustic microscopy and methods for employing such systems. In certain embodiments, such systems employ a low-energy nanosecond pulsed laser beam (NPLB), at least two amplifiers, and a data acquisition system with at least three channels to generate at least three digital signals (e.g., which are averaged and normalized to the energy of the NPLB). In other embodiments, provided herein are systems for combined use of photoacoustic microscopy, dye-based microscopy (e.g., with fluorescein), and optical coherence tomography.

Abstract: System and method for fully automated end-to-end eye screening with automated medical acquisition and analysis. The system includes an eye imaging device, a mechanism that moves the imaging device, a computing platform that guides the movement mechanism, a user interface, and an electronic display device and/or printer to provide the screening, monitoring, and/or diagnosis report.

Abstract: A wide field fundus camera is disclosed to implement multiple illumination beam projectors and to capture multiple retinal images at various viewing angles to facilitate wide field retinal examination. The wide field fundus camera contemplates an ultra-wide field lens that can provide edge to edge imaging of the entire retina at a single alignment. The wide field fundus camera contemplates configuration of said multiple illumination beam projectors to provide visualization of retina and Purkinje reflections simultaneously to facilitate determination of proper camera alignment with the eye. The wide field fundus camera further contemplates control of multiple illumination beam projectors in a programmable manner to further assess alignment of each illumination beam projector with the eye and to capture said multiple retinal images.

Abstract: Disclosed herein are methods, devices, and systems for monitoring fluid outflow behavior of an eye of a subject, for example, during ocular surgery. Changes to intraocular pressure can reflect fluid outflow behavior. Fluid outflow behavior can be a critical factor in the successful outcome of a surgery and determining likelihood of post-operative side effects. Large fluctuations in intraocular pressure, ocular hypertension, and hypotony can be associated with vision loss or poor ocular health.

Abstract: The present invention provides a wellness monitoring system provided with one or more processors and a memory coupled to the one or more processors. The wellness monitoring system includes a first device, a system cloud server, and a second device. The first device is handled by a first person. The first device includes a routine monitoring application configured to collect a set of data associated with the first person. The system cloud server is connected with the first device and the second device through a communication network. The system cloud server collects and stores the set of data collected by the routine monitoring application. The second device is associated with a second person, wherein the second device is configured to review, analyze, and compare, the set of data stored at the system cloud server.

Abstract: Methods and devices for transmitting and receiving data through biological tissue using ultrasonic pulses are described. Methods of the present invention may set an initial time-hopping frame length and an initial spreading code length for data transmission. A request-to-transmit may be sent from a transmitter over a control channel at the initial frame and code length. The receiver may respond to the transmitter with a clear-to-transmit packet having feedback information. The feedback information can be used to improve a forward time-hopping frame length and a forward spreading code length. Embodiments of the invention may involve a body area network or body surface network comprising a plurality of implanted sensor nodes operating according to the disclosed invention.

Abstract: Medical conditions in tissues are simultaneously imaged and treated using light within selected wavelength ranges. By treating conditions, such as wounds, lesions, and tumors, at the same time that they are imaged, the overall diagnostic and treatment time is substantially reduced.

Abstract: A process for medical imaging, the process including: (i) receiving scattering data representing mono-static or multi-static measurements of scattering of electromagnetic signals from tissues of a body part of a subject at a plurality of different signal frequencies, wherein electromagnetic signals are emitted from one or more antennas and the corresponding scattered signals are measured by the one or more antennas; (ii) processing the scattering data to calculate electric field power values at each of a plurality of scattering locations of the subject's tissues within the body part and for each of the plurality of frequencies; (iii) for each of the scattering locations, summing the calculated electric field power values at the scattering location over the plurality of frequencies and the plurality of antennas to generate an image of the tissues within the body part; and (iv) iteratively updating a model of the tissues within the body part based on a comparison of the model with the generated image until a

Abstract: Systems, devices, and methods for isolating and protecting patients during medical imaging procedures. The devices generally related to disposable personal protective equipment (PPE) that may be used to isolate patients and prevent cross-contamination of infectious diseases during medical imaging.

Abstract: The present disclosure relates to method of performing an interventional procedure using flexible probes with a compound or a composition comprising the compound, wherein the compound comprises a targeting moiety, wherein the targeting moiety targets a receptor, antigen, or antibody and a fluorescence imaging agent.

Abstract: A processing device may receive a plurality of intraoral scans of the patient that were generated by an intraoral scanner, determine a three-dimensional surface of at least a portion of one or more dental arch of the patient using the plurality of intraoral scans, automatically determine whether a restorative dental object is represented in at least one of the three-dimensional surface or one or more intraoral scans of the plurality of intraoral scans, and automatically generate a prescription for treating the one or more teeth based at least in part on at least one of a) a presence or absence of a restorative dental object in at least one of the three-dimensional surface or the one or more intraoral scans or b) a location of the restorative dental object in the one or more dental arch of the patient.

Abstract: A processing device receives a plurality of intraoral scans of a dental arch. The processing device determines, from the plurality of intraoral scans, a first set of intraoral scans that depict a restorative object and a second set of intraoral scans that fail to depict any restorative object. The processing device generates a multi-resolution three-dimensional model of the dental arch, wherein a first portion of the multi-resolution three-dimensional model is generated from the first set of intraoral scans, has a first resolution and represents the restorative object, and wherein a second portion of the multi-resolution three-dimensional model is generated from the second set of intraoral scans, has a second resolution and represents a remainder of the dental arch, wherein the first resolution is greater than the second resolution.

Abstract: A method of generating a 3D model includes: determining a 3D surface comprising a preparation tooth using a first plurality of intraoral scans generated by an intraoral scanner at a first time; receiving one or more additional intraoral scans of the preparation tooth that were generated by the intraoral scanner at a second time; determining a change to one or more portions of the preparation tooth between the three-dimensional surface and the one or more additional intraoral scans; determining, based at least in part on the change to the preparation tooth, whether to use a) the 3D surface, b) data from the one or more additional intraoral scans or c) a combination of the 3D surface and the data from the one or more additional intraoral scans to depict one or more portions of the preparation tooth; and generating the 3D model comprising the preparation tooth.

Abstract: A portable or semi-portable kiosk configured as a human body temperature scanning device, connected to a network that is also linked to a health history database and configured to allow or deny access to a building to a user.

Abstract: Methods, systems, and devices for direct radio frequency (RF) signal processing for heart rate (HR) monitoring using ultra-wide band (UWB) impulse radar are presented. A radar sensor is able to directly sample a received signal at RF which satisfies the Nyquist sampling rate, preserving a subject's vital sign information in the received signal. The vital sign information can be extracted directly from a raw RF signal and thus down conversion to a complex baseband is not required. The HR monitoring performance from the proposed direct RF signal processing technique provides an improvement in continuous HR monitoring as compared against existing methods using a complex baseband signal and/or other measurement techniques.

Abstract: Wireless systems and methods are provided for protecting vital organs from blood flow loss, and for physiological monitoring of a subject in various settings. The systems and methods permit the coordinated delivery of various treatment protocols involving inflation or deflation of cuffs to multiple limbs of the subject.

Abstract: A gas delivery conduit adapted for fluidly connecting to a respiratory gases delivery system in a high flow therapy system, the gas delivery conduit includes a first connector adapted for connecting to the respiratory gases delivery system, a second connector adapted for connecting to a fitting of a patient interface, tubing fluidly connecting the first connector to the second connector where the first connector has a gas inlet adapted to receive the supplied respiratory gas, one of electrical contacts and temperature contacts integrated into the first connector. The gas delivery conduit further can include a sensing conduit integrated into the gas delivery conduit, where the first connector of the gas delivery conduit is adapted to allow the user to couple the first connector with the respiratory gases delivery system in a single motion.

Abstract: A gas delivery conduit adapted for fluidly connecting to a respiratory gases delivery system in a high flow therapy system, the gas delivery conduit includes a first connector adapted for connecting to the respiratory gases delivery system, a second connector adapted for connecting to a fitting of a patient interface, tubing fluidly connecting the first connector to the second connector where the first connector has a gas inlet adapted to receive the supplied respiratory gas, one of electrical contacts and temperature contacts integrated into the first connector. The gas delivery conduit further can include a sensing conduit integrated into the gas delivery conduit, where the first connector of the gas delivery conduit is adapted to allow the user to couple the first connector with the respiratory gases delivery system in a single motion.

Abstract: A method for assessing a state of a cardiovascular system includes receiving a blood pressure Pa and a blood flow Qa of the cardiovascular system; calculating with a fractional-order, viscoelastic Windkessel model an arterial compliance C? of the cardiovascular system; and evaluating the state of the cardiovascular system based on a fractional-order parameter ? associated with the fractional-order, viscoelastic Windkessel model.

Abstract: Devices, systems, and methods for visually depicting a vessel and evaluating treatment options are disclosed. The methods can include obtaining pressure measurements from first and second instruments positioned within a vessel of a patient while the second instrument is moved longitudinally through the vessel from a first position to a second position and the first instrument remains stationary within the vessel; and outputting a visual representation of the pressure measurements obtained by the first and second instruments on a display, the output visual representation including a graphical display of a pressure ratio of the obtained pressure measurements and at least a portion of a pressure waveform of the obtained pressure measurements identifying a diagnostic period utilized in calculating the pressure ratio.

Abstract: A system (100) and a method for analyzing a physiological condition of a user. The system (100) comprises one or more sensors (102a, 102b) to measure one or more parameters including temperature and relative humidity from the user's skin and/or a corresponding temperature and relative humidity from the user's environment via an air gap. A signal representative of the measured parameters is generated. The system (100) also includes at least one transceiver (108) communicably connectable to the sensing unit (102) via one or more communication interfaces, wherein the transceiver (108) is configurable to analyze one or more received signals to initiate one or more events based on the analyzed parameters of the user. The system (100) further includes a processing unit (110) to receive one or more signals from the transceiver (108) and uses artificial intelligence and machine learning techniques to alert users of an impending physiological condition.

Abstract: The present invention relates to an apparatus and a method for determining an indication of blood flow in a limb. According to an embodiment, the apparatus comprises an orientation sensor, a blood volume (BV) measuring device and a control unit. The orientation sensor is configured to determine an orientation of the limb and output an orientation signal indicative thereof. The blood volume measurement device is configured to measure an indication of blood volume (BV) in the limb and output a BV signal indicative thereof. The control unit is arranged to receive the orientation signal and the BV signal, determine a change in orientation of the limb in dependence on the orientation signal, and correlate the change in orientation with a change in blood volume of the limb determined in dependence on the BV signal.

Abstract: A method includes obtaining a baseline blood pressure at an initial time window; estimating a plurality of intermediate blood pressure change estimates, the intermediate blood pressure change estimates correspond to respective time windows that are subsequent to the initial time window; estimating a final blood pressure change estimate between the initial and final time windows; and obtaining the blood pressure by adding the baseline blood pressure to the final blood pressure change estimate. Estimating the final blood pressure includes estimating a first blood pressure change between the initial time window and the final time window; estimating a plurality of second blood pressure changes, each second blood pressure change is between a respective time window of the respective time windows and the final time window; and estimating the final blood pressure change estimate as a combination of the first blood pressure change and the plurality of second blood pressure changes.

Abstract: Measuring, using a wearable device, a blood pressure of a user includes extracting, using sensor data of the wearable device, features related to a pulse wave; determining a pulse transit time (PTT); scaling at least one of the features using the PTT to obtain a scaled feature; using the scaled feature as an input to a machine-learning (ML) model; and obtaining, using an output of the ML model, the blood pressure of the user.

Abstract: The present invention relates to a method of analysing cardiac data relating to a patient, comprising: providing cardiac data relating to the patient—optionally by using a means for providing physiological data (20); determining one or more properties of the data, wherein the or each property is determined over a particular context length, the context length being selected based on the or each property—optionally using an analysis module (24); comparing the or each property against a respective predetermined threshold value, thereby to indicate a probability of the patient experiencing a cardiac event—optionally using a means for providing an output (26); and providing an output based on the comparison. A system and apparatus corresponding to this method is also disclosed.

Abstract: A method for determining one or more physiological parameters of a subject. The method includes providing a plurality of images of a vessel of the subject in response to illumination of the vessel to light of different wavelengths; converting each of the plurality of images of the vessel into at least two grayscale images, thereby generating a plurality of first grayscale images of a first wavelength range and a plurality of second grayscale images of a second wavelength range, the first wavelength range and the second wavelength range being different from each other; and determining the one or more physiological parameters of the subject based on at least the plurality of first grayscale images and the plurality of second grayscale images.

Abstract: Wearable data acquisition devices including sensors for detecting physiological signals are used to detect and measure various parameters pertaining to the health of the wearer. Through the use of algorithms, the data detected and measured by said sensors are processed to make inferences used to monitor the health of the wearer. An signal to noise ratio (SNR) calculation is used as a component of the sensitivity analysis of an algorithm. For example, a sleep algorithm will select a block of data, the SNR calculation will be done, with the average quality of the signal as result. The value associated with said signal quality may then be subjected to sensitivity analysis, which will yield a sleep accuracy value which, in turn, is indicative of the minimum signal quality which is required.

Abstract: Examples of 3D-printed sensing devices for detecting vascular conditions in an animal body are described. A 3D-printed sensing device may comprise a binding layer to attach the 3D-printed sensing device to a part of the animal body. A sensor layer is extruded atop the binding layer. The sensor layer comprises a piezoresistive transducer to generate an electrical signal based on a pulse detected in the part of the animal body. In an example, the electrical signal is a binary signal having a logical high value at an instant of occurrence of the pulse and is agnostic of a strength of the pulse. An amplification module in the sensor layer may amplify the electrical signal and provide the amplified signal to a transmitter unit of the 3D-printed sensing device to transmit the amplified signal to a monitoring device associated with the 3D-printed sensing device.

Abstract: A wearable antenna assembly for tomographic brain imaging of a subject, the antenna assembly including: a resilient cap to be worn on the head of a subject whose brain is to be imaged; an array of antennas at least partially embedded in the cap at respective mutually spaced locations such that, when the cap is worn by the subject, the antennas are arranged around the subject's brain; wherein the cap has a multi-layered structure including a layer composed of graphite and aluminium oxide powders dispersed in PDMS to improve the matching of dielectric properties with those of the subject's head.

Abstract: Rapid quantitative evaluations of heart function are carried out with strain measurements from Magnetic Resonance Imaging (MRI) images using a circuit at least partially onboard or in communication with an MRI Scanner and in communication with the at least one display, the circuit including at least one processor that: obtains a plurality of series of MRI images of long and short axis planes of a heart of a patient, with each series of the MRI images is taken over a different single beat of the heart of the patient during an image session that is five minutes or less of active scan time and with the patient in a bore of the MRI Scanner; measures strain of myocardial heart tissue of the heart of the patient based on the plurality of series of MRI images of the heart of the patient; and generates longitudinal and circumferential heart models with a plurality of adjacent compartments, wherein the compartments are color-coded based on the measured strain.

Abstract: Embodiments of the present disclosure include a medical device, comprising an elongate shaft extending along a shaft longitudinal axis and comprising a shaft proximal portion and a shaft distal portion. A navigational assembly is connected to the shaft distal portion and extends along the shaft longitudinal axis. The navigational assembly includes a navigational electrode positioning feature and a magnetic position sensor positioning feature.

Abstract: A guidance system for assisting with the insertion of a needle into a patient body is disclosed. The guidance system utilizes ultrasound imaging or other suitable imaging technology. In one embodiment, the guidance system comprises an imaging device including a probe for producing an image of an internal body portion target, such as a vessel. One or more sensors are included with the probe. The sensors sense a detectable characteristic related to the needle, such as a magnetic field of a magnet included with the needle. The system includes a processor that uses data relating to the sensed characteristic to determine a 3-D position of the needle. The system includes a display for depicting the position of the needle. A needle assembly including a hub, cannula, and magnetic element is also disclosed, wherein the cannula is substantially non-magnetic so as to not distort the magnetic field of the magnetic element.

Abstract: Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the residence articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the residence article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the residence article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the residence articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the residence article includes dimensions configured for transesophageal retrieval. In some cases, the residence articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).

Abstract: A method for measuring changes in respiration using measurement data representing a plurality of measured respiration cycles in the form of flow and volume of respiration, or flow and time of respiration, or time and volume of respiration, over a duration of time, and wherein such measurement data pertains to at least the expiration phase measurement of the respiration cycles, analyzing variability of the expiration phases of flow-volume, flow-time or time-volume measurements of the respiration cycles wherein the measurements are measurements over a duration of time, wherein the variability between the expiration phases of the respiration cycles is analyzed from the measurement data in the range of the first half of expired volume in the expiration phase of the respiration cycles. A corresponding arrangement and a computer program product are also presented.

Abstract: A computer-implemented method is for classifying a body type of at least one person. In an embodiment, the method includes receiving at least one image data record of the respective person, which maps at least one subarea of the person; and ascertaining a body type for the person by an optimization method. A respective person model is used for each of the possible body types, which as a function of at least one person parameter determines an expected person geometry of the person described by the person model. The body type is selected by the optimization method by a similarity measure for the similarity of the image data record or a person geometry ascertained from the image data record being optimized with the expected person geometry by selecting the body type.

Abstract: A walking assistance method may include measuring a current gait motion of a user, defining a state variable based on the current gait motion, setting a delay that is a feedback element for the state variable, and generating a torque profile based on the state variable and the delay.

Abstract: Biometric identification methods and apparatuses (including devices and systems) for uniquely identifying one an individual based on wearable garments including a plurality of sensors, including but not limited to sensors having multiple sensing modalities (e.g., movement, respiratory movements, heart rate, ECG, EEG, etc.).

Abstract: A patient support apparatus, such as a bed, cot, stretcher, etc., for supporting a patient includes an exit detection system with multiple user-selectable modes of operation that each have different sensitivity levels for triggering an exit alert. The exit detection system also includes one or more non-user selectable modes of operation that are automatically implemented in response to a triggering action. For example, a transition mode may be automatically implemented when the user attempts to switch from a first user-selectable mode to a different user selectable mode, or a motion mode may be automatically implemented when movement of one or more components of the patient support apparatus occurs. In the transition mode, the exit detection system may use a least restrictive sensitivity level. In the motion mode, the exit detection system may inhibit exit alerts and/or change the criteria for issuing the exit alert.

Abstract: Provided is a system and method for smart dental unit. The system provides smart dental unit restoring one or more teeth, including: a prosthetic base structured and arranged to engage with mouth tissue. The prosthetic base supports at least one tooth and at least one sensor system structured and arranged to detect at least one event. The sensor system further has a processor coupled to a wireless transceiver operable to communicate with at least one remote computing system. The smart dental unit also has a unique identifier. In response to a detected event the processor generates data communicated by the wireless transceiver to the remote computer. The unique identifier is also used by the remote computer to determine the location of the smart dental unit. An associated method for making a smart dental unit and a system for dental based patient care are also disclosed.

Abstract: A method is provided which includes providing a sensor operable to measure movement over time on a user. The sensor includes an alert unit. The sensor is configured with a threshold to activate the alert unit when the measured movement over time is below the threshold. The measurements of movement over time are obtained, and it is determined whether the measured movement over time is below the threshold. When the measured movement is below the threshold, the alert unit at the sensor is activated to alert the user.

Abstract: The invention relates to a test to measure the ability of a subject to discriminate between speech sounds. The speech sounds may be selected from the worlds most widely spoken languages to enable the test to be carried out irrespective of the language spoken by the subject. Speech sounds may be presented in sequences, such as triplets. The subject would then be required to detect which speech sound in each sequence is different from the others. The test may be provided on a computer or similar device, in an embodiment a tablet computer, enabling the subject to conduct a self-assessment. The test may be performed on hearing aid users to determine the likelihood of a hearing aid user obtaining better test results after receiving one or two cochlear implants.

Abstract: A spectroscopic laser sensor based on hybrid III-V/IV system-on-a-chip technology. The laser sensor is configured to either (i) be used with a fiber-optic probe connected to an intravenous/intra-arterial optical catheter for direct invasive blood analyte concentration level measurement or (ii) be used to measure blood analyte concentration level non-invasively through an optical interface attached, e.g., to the skin or fingernail bed of a human. The sensor includes a III-V gain-chip, e.g., an AlGaInAsSb/GaSb based gain-chip and a photonic integrated circuit, with laser wavelength filtering, laser wavelength tuning, laser wavelength monitoring, laser signal monitoring and signal output sections realized on a chip by combining IV-based semiconductor substrates and flip-chip AlGaInAsSb/GaSb based photodetectors and embedded electronics for signal processing.

Abstract: One embodiment is a multi-analyte molecular sensing system designed for implantation in a body of a subject, the sensing system including an implant comprising a flexible substrate having a plurality of electronics systems disposed thereon; a sensor array comprising multiple sensors disposed on the flexible substrate; a sensor protection mechanism for providing selective protection and exposure of one or more of the sensors; a power system for providing power to the electronics systems; a data communication system for communicating with one or more external devices; and a biocompatible housing for protecting the implant.

Abstract: Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies E1, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies E1, E2, and working electrodes 802?, 802? formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies E1, E2.