Abstract: An intravenous fluid bag comprising: a primary chamber configured to retain a liquid; a valve in fluid communication with the primary chamber, the valve including a housing, a spike element, and a seal, with the housing surrounding the seal, which surrounds the spike element; the spike element having a first end culminating in a tip, a second end having an inner conduit, and one or more through holes between the tip and the second end in fluid communication with the inner conduit forming part of a continuous liquid passageway in fluid communication with the primary chamber; the seal having a relaxed state preventing fluid flow through the valve, and the seal having a compressed state through which the through holes of the spike element extend allowing fluid flow from a source external the intravenous fluid bag, through the through holes, through the inner conduit, and into the primary chamber.

Abstract: The invention relates to an infusion container comprising a sterile, ready-to-use, stable aqueous solution of Midazolam or a pharmaceutically acceptable salt thereof, suitable for direct intravenous infusion to a patient in need thereof.

Abstract: A container unit may be used to facilitate administrations of multiple medicinal fluids to a patient. A container unit may include a first container, a second container, and a carrier which holds the first container and the second container stationary relative to each other. The carrier may include a lip configured to engage a pooling device to secure the container unit to the pooling device. The carrier may also include a slot configured to engage an insert on the pooling device to guide the container unit as the container unit is secured to the pooling device. The carrier may also include a first portion and second portion with different shapes that are complementary to a shape of a port on the pooling device. The carrier may also include an extension which extends in a direction away from one of the first container to a level at least even with a stopper disposed in the first container.

Abstract: A reconstitution device includes: a piercing member having a first end and a second end, the first end of the piercing member configured to engage an administration port; a delivery member having a first end and a second end, the first end of the delivery member configured to engage a delivery site; a collar configured to engage a vial; and a cap extending from the collar and holding the piercing member and the delivery member such that the second end of the piercing member and the second end of the delivery member are disposed within the cylindrical collar.

Abstract: The invention relates to an installation for producing a medical preparation, in particular for producing a preparation for parenteral nutrition. The installation comprises a pump with which liquids can be transferred from a plurality of source containers into a target container. The installation has a modular construction and comprises a weighing module and a main module with the pump. According to a further aspect of the invention, the pump is arranged at an inclination with respect to a vertical plane. According to a further aspect of the invention, the installation comprises cascaded valve nodes.

Abstract: This medicine case comprises: a case body for accommodating a medicine, the case body being such that a discharge opening for the medicine is provided in a bottom part thereof; and a rotating member disposed inside the case body, the rotating member rotating about a rotating shaft. The rotating member has a first side wall member and a second side wall member that are parallel to each other and that constitute a passage through which the medicine is guided to the discharge opening. The first side wall member and the second side wall member approach and separate from each other while remaining parallel to each other, adjusting the width of the passage.

Abstract: It is vital to use the right medicine at the right time, at the right dose while taking medicines; forgetting to take medicines is a problem seen in patients with forgetfulness or carelessness, especially elderly patients, and in patients who are on continuous medication and/or have to use a medicine for a certain period. The synchronized medication tracking system of the present invention is designed to solve the problems of the patients. The present invention includes a cartridge that can be carried on patients at all times, a filling device for placing the medicines in portable cartridges, and an application to allow tracking this information.

Abstract: A long, thin, flexible medical apparatus, a kit including such an apparatus, and a method for employing the apparatus to assist in placing a distal portion of a lumen of a gastric tube in a stomach of a mammal. The apparatus comprises an elongate body portion, a handle portion fixed to a proximal end of the body portion, and a distal tip portion fixed to a distal end of the body portion. An ability to insert the body and distal tip portions into the gastric tube over the length of the long, thin, flexible structure provides a positive indication that the lumen is not blocked, obstructed, or otherwise compromised over that length. pH indicator sensors may be retained by the distal tip portion to exhibit a verifiable color change in response to contact with a predetermined subject fluid, such as gastric fluid, lung fluid, or another bodily fluid.

Abstract: In some embodiments, apparatuses and methods are provided herein useful to provide fluid nutrition and hydration. In one illustrative example, a feeding set for use with a peristaltic enteral feeding pump has sections of flexible tubing or conduit, a dispensing control valve that is in fluid communication with the tubing, and a retention disk. In some configurations, the feeding set has as attachment mechanism, which may be formed by one clips or hooks extending from the dispensing control valve and coupling geometry of the retention disk. By some approaches, the clips or hooks and the coupling geometry are configured to attach the feeding set with the pump, such as by attaching the feeding set to an internal panel of the feeding pump. In operation, the feeding set and pump are used to move fluid nutrition and hydration from a container or bag to the patient in a controlled manner.

Abstract: A wipe comprising a flexible body is disclosed herewith. The wipe may be provided as a component of a wipe and a bag kit having the wipe and a bag, the wipe disposed within the bag. The wipe comprises a flexible body having an open end. The flexible body may be constructed of fabric. The wipe can be shaped and dimensioned complementary to a human male penis such that the human male penis may be inserted into the open end. The wipe may be pre-wetted with water and one or more additives.

Abstract: An antimicrobial eyelid cleanser composition contains: (a) a hypohalous acid; (b) one or more surfactants having a HLB value of 5 to 18; and (c) an aqueous vehicle, the aqueous vehicle comprising: (i) one or more tonicity adjusters; (ii) one or more osmolality adjusters for adjusting an osmolality of the composition; and (iii) one or more pH adjusters for maintaining the pH of the composition at between about 4.5 to about 8.0. The composition can be dispensed in a foam, liquid, spray, mist, gel or lotion form. The composition can facilitate long term eyelid hygiene by removing excess oil, debris and desquamated skin and provide relief for inflammation of the eyes.

Abstract: An advantageous deodorizing composition comprising at least one zinc carboxylate salt and aluminium chlorohydrate is provided, as well as a deodorant consumer product comprising the same. Furthermore, a method of suspending aluminium chlorohydrate in an at least essentially anhydrous solvent is provided, as well as a method of preventing clumping of aluminium chlorohydrate in a deodorizing composition or a deodorant consumer product and a method of preventing clogging of a nozzle of a deodorant spray containing a deodorizing composition.

Abstract: Ultraviolet radiation sun protective compositions are reported which feature micronized metal oxide inorganic particles selected from zinc oxide, titanium dioxide and mixtures thereof, the inorganic particles being coated with an adduct of a hydroxy cinnamate and a silanol, amounts of the adduct to the inorganic particles being in a relative weight ratio of 1:200 to 1:4.

Abstract: An oily stick-shaped cosmetic containing (A) a partially hydrogenated jojoba ester, (B) Japan wax, (C) a higher fatty acid, and (D) a dimer acid ester.

Abstract: Described herein are personal care compositions that includes a carrier; a structuring agent that is ionic; and a surfactant blend comprising a zwitterionic surfactant and cetrimonium chloride.

Abstract: Aspects of the disclosure relate to hair treatment compositions including about 0.1 to about 10 wt. % of a cationic surfactant; about 0.1 to about 10 wt. % of a fatty acid having a carbon chain of 12 or more carbons; about 0.1 to about 20 wt. % of a fatty alcohol; and about 50 wt. % or more of water, wherein all weight percentages are based on the total weight of the hair treatment composition. Additionally, the hair treatment compositions are formulated to have a molar ratio of the total amount of cationic surfactant to the total amount of fatty acid is about 1:0.8 to about 1:3 and a pH of about 2.5 to about 5.5. The disclosure also relates to methods for applying such hair treatment compositions.

Abstract: A micromolecular organic method based on the mixed application of different active ingredients to provide an excellent corrective effect of the aesthetic and cosmetic alterations typical of aging. The active ingredients have synergistic effects, which potentiates or increases the effect on each other due the method of their combination. In addition to maintaining the good results achieved for a long time, the formulations, quantities, concentrations, sequencing, synergy, potentiation, amplification of effects, spatial structure effects relationship, form of administration, etc. present a wide margin of tolerance to the skin. The method including applying a BioNutrient MBM, a BioGel MBM, a BioExfoliant No. 1, a BioExfoliant No. 2, a cleaning mask, a face cleaner, a deep cleaner, a moisturizing lotion No. 1, a SPF lotion, a moisturizing lotion No. 2 with soothing effect and AntiSpot lotion to skin.

Abstract: The present invention relates to a process for coloring keratin fibers, preferably hair, comprising the steps of: (i) applying onto the keratin fibers a composition comprising (a) at least one compound chosen from alkylaminosulfonic acids and those of the formula (I) and (II), (b) at least one direct dye, and (c) at least one alkaline agent; (ii) heating the keratin fibers; and (iii) optionally rinsing and/or drying the keratin fibers. The present invention can provide superior coloring efficiency, such as color intensity and color lastingness.

Abstract: The disclosure relates to compositions and methods for removing direct dyes from hair, the methods comprising contacting hair with a composition comprising (i) at least one organic salt selected from imidazolium-based compounds and/or ammonium-based compounds, and (ii) at least one surfactant. The compositions can further contain at least one co-surfactant and/or cyclic compound.

Abstract: The present disclosure is directed to compositions and methods for providing increased skin care benefits and/or multiple skin care benefits. The methods and compositions disclosed herein are directed to skin care compositions and skin care products comprising at least four osmolytes selected from amino acids, methyl-amines and polyols. More specifically, the methods and compositions disclosed herein are directed to skin care compositions and skin care products comprising a combination of at least four osmolytes selected from the group consisting of betaine, inositol, proline and serine.

Abstract: A toothpaste composition for alleviating dentin hyperesthesia is disclosed. The composition includes a peptide consisting of an amino acid sequence of the following Formula 1: K-Y-R1-R2-R3-R4-R5-R6-R7-R8??(Formula 1) wherein R1 is arginine (R), lysine (K) or glutamine (Q); R2 is arginine (R) or glutamine (Q); R3, R4, and R5 are arginine (R) or lysine (K), respectively; R6 is asparagine (N) or serine (S); and R7 and R8 are lysine (K) or tyrosine (Y), respectively.

Abstract: The present disclosure relates to a peptide consisting of an amino acid sequence of SEQ ID NO: 1, 2, 3, or 4, a pharmaceutical composition for preventing or treating skin disease including the peptide, a cosmetic composition for skin condition improvement including the peptide, a food composition for skin condition improvement including the peptide, a method of preventing or treating skin disease using the peptide, and a use of the peptide in preventing or treating skin disease or improving skin condition.

Abstract: Disclosed are stable, non-irritating, retinoid containing formulations for topical application to the skin for modulated sheet-peeling of the skin without inflammatory response that retards healing of the skin. The topical formulations have concentration levels of ingredients, including retinol, a retinol activation system having a surfactant and a solvent, anti-inflammatory agents, that are formulated for exfoliating skin in skincare treatments such as chemexfoliation, peeling, dermal restructuring, without associated inflammatory affects, such as irritation, redness, drying, oozing, swelling, tenderness of skin, which retard healing of the skin. Also provided are methods for the formulation, manufacture and use of the disclosed formulations.

Abstract: Disclosed is an efficacious, low-pH skin care composition that provides good sensory properties and has a low skin irritation potential. The low-pH composition includes an effective amount of a vitamin B3 compound and, optionally, one or more additional skin care actives to provide a skin health and/or appearance benefit. The low-pH composition also includes a pH buffer comprising lactic acid and sodium lactate, a polymer thickener comprising polyacrylate crosspolymer-6, and a silicone fluid having a kinematic viscosity of 100 cSt or less at 25° C. The pH of the low-pH composition can range from 2.0 to 5.0.

Abstract: Disclosed is a method of improving the penetration of a vitamin B3 compound into skin. The method involves a skin care regimen in which at least two skin care compositions are used in sequence to treat a target portion of skin where a skin health or appearance benefit is desired. The first composition applied to the skin is a low-pH skin care composition that contains a first concentration of a vitamin B3 compound. The second skin care composition applied to the skin is a conventional skin care composition that contains a higher concentration of the vitamin B3 compound than the first composition. When applied in the proper sequence, the regimen results in an unexpectedly high vitamin B3 flux into the skin.

Abstract: Disclosed is an efficacious, low-pH skin care composition that provides good sensory properties and has a low skin irritation potential. The low-pH composition includes an effective amount of a vitamin B3 compound and, optionally, one or more additional skin care actives to provide a skin health and/or appearance benefit. The low-pH composition also includes a salt/acid pH buffer system, an acid tolerant polymeric thickener and, optionally, a silicone fluid having a kinematic viscosity of 100 cSt or less at 25° C. The pH of the low-pH composition can range from 2.0 to 5.0.

Abstract: Compositions for reducing/eliminating aerosolization during dental/surgical irrigation procedures are set forth. One or more of the compositions herein can be provided in substantially similar concentrations to reduce/eliminate aerosolization.

Abstract: The instant disclosure relates to hair treatment compositions that include a unique combination of components that function to impart desirable cosmetic properties to the hair. The hair treatment compositions typically include: at least 0.5 wt. % of at least one non-polymeric mono, di, or tricarboxylic acid, and/or a salt thereof; one or more amines selected from the group consisting of diamines, polyamines, alkylamines, alkanolamines, and a mixture thereof; one or more fructan polysaccharides; one or more prosolvents; and water.

Abstract: A skin care composition comprising low molecular weight acetylated hyaluronic acid or its sodium salt having a weight average molecular weight less than 50 kDa, and a degree of acetylation of at least 3.6 is useful in the treatment of the visible effects of age on human skin.

Abstract: A composition of materials for creating a hyper-effective base for various skin care, body care, and hair care formulations is disclosed. The resulting composition of materials is a superior moisturizing oil. The disclosed composition of materials provides numerous skin benefits including but not limited to improving overall skin tone and appearance, reducing inflammation and moisturizing the skin.

Abstract: A composition for sebum control and pore reduction, and its use for controlling sebum and reducing pore of skin are disclosed. The external-use skin preparation composition contains, as an active ingredient, extracts of one or more medicinal herbs selected from the group consisting of Cimicifugae rhizoma, Solani nigri herba, Glycyrrhiza uralensis, Clematis mandshurica, Acanthopanax senticosus, Inulae radix and Dioscorea japonica, and thus it not only can control the production of sebum and alleviate skin troubles, but also provide antioxidant effects, prevent pore enlargement, or prevent occurrence of skin irritation.

Abstract: The present invention relates to a cosmetic composition for topical application to the skin comprising, in a physiologically acceptable medium, at least one effective amount of at least one aqueous extract of rose fruit distinct from the fruit of the dog rose (i.e. Rosa canina), in particular an aqueous extract of rose fruit of the Evanrat or Jardin de Granville® rose variety, and the use of same in particular to promote and/or improve the supply of nutrients to the skin, to strengthen the barrier function and to densify the extracellular matrix, in particular for the eye contour area.

Abstract: The present invention relates generally to cosmetic compositions and methods that can be used to increase skin hydration, increase adenosine triphosphate (ATP) production in skin, increase antioxidant capacity of skin, reduce glycation of skin, or a combination thereof. In particular, topical application of the compositions to skin increases adenosine triphosphate (ATP) production in skin by at least 10%, increases antioxidant capacity of skin, and/or reduces glycation of skin by at least 50%. In particular, the compositions can include Chamomilla recutita (Matricaria) flower extract, Vitis vinifera (Grape) seed extract, hydrolyzed sodium hyaluronate, Natural Moisturizing Factors (NMF), and optionally carnosine.

Abstract: One aspect of the present invention provides an anti-obesity agent, an anti-dementia agent, a deodorant, an anti-aging agent, an anti-glycation agent, an anti-type I allergy agent, a hypotensive agent, a flavor improving agent, a muscle enhancing agent, and a bone metabolism improving agent which contain a bagasse decomposition extract as an active ingredient.

Abstract: This invention relates to a composition comprising amnion homogenate in admixture with a biologically acceptable excipient such as a hydrogel, which may be useful as a therapeutic or cosmetic composition and in particular as a wound dressing, a scar dressing, a topical hydrogel or a topical ointment. This invention also relates to devices such as wound dressings and cosmetic patches comprising the composition and to methods of making and using the composition or device.

Abstract: A method of treating skin in a subject is provided. A method of reducing an appearance or effect of aging in a subject is also provided. Methods of improving skin integrity and/or skin surface topology in a subject are further provided. The methods comprise administering an effective amount of a preparation comprising ammonia oxidizing microorganisms to the subject. Related preparations and kits are also provided.

Abstract: Compositions for use in oral hygiene contain a Lactobacillus helveticus strain. Compositions further containing a Lactobacillus plantarum strain, especially Lactobacillus plantarum SD5870, are particularly effective. The combination of Lactobacillus helveticus LAFTI L10 and Lactobacillus plantarum SD5870 synergistically improves oral hygiene. The compositions are particularly useful against dental caries.

Abstract: The present invention relates to a film comprising an alginate salt of a monovalent cation or a mixture of alginate salts containing at least one alginate salt of a monovalent cation, and a compound of Formula (I), such as adrenaline, or a pharmaceutically acceptable salt thereof. The present invention further relates to methods for manufacturing such a film, and the use of such a film in the treatment of a human patient, in particular the use of such a film in the treatment of a condition selected from anaphylaxis, superficial bleeding and cardiac arrest.

Abstract: The present invention provides oral care compositions. The compositions may be provided in a solid form, such as a film. The compositions can comprise one or more film forming polymers, one or more bioadhesive agents, one or more plasticizers, benzocaine (and optionally one or more further active ingredients), one or more polymeric solvents, and an aqueous solvent. The oral care composition can be a solid or semi-solid composition up to a temperature of at least 40° C. Methods of providing such an oral care compositions are also provided herein.

Abstract: Embodiments of the disclosure relate to dosage forms intended for smoking, vaporization and/or inhalation and to methods for the preparations thereof.

Abstract: Stable, ready-to-use injectable pharmaceutical compositions are provided, comprising the combination of neostigmine, glycopyrrolate, and a pharmaceutically acceptable liquid vehicle, optionally with additional pharmaceutically acceptable excipients. Other aspects of the invention relate to methods for making such compositions and methods of using such compositions for reversing the effects of non-depolarizing neuromuscular blocking agents. Preferably, the composition comprises neostigmine methylsulfate, glycopyrronium bromide, and a pharmaceutically acceptable liquid vehicle, and is provided in a pre-filled, ready-to-use sealed container, such as a pre-filled syringe, suitable for intravenous administration.

Abstract: The present invention relates to a vaginal sustained-release drug delivery system for luteal support and a method for preparation and use thereof. The vaginal sustained-release drug delivery system for luteal support is a progesterone depot-type vaginal ring having a bilayer structure of a core layer and a film layer enclosing the core layer, wherein the core layer is composed of a solid scaffold carrier of medical EVA containing a drug uniformly dispersed therein, and the film layer is composed of a medical EVA material containing no drug. The vaginal sustained-release drug delivery system for luteal support according to the present invention can be used for assisted reproduction and for treatment of functional uterine bleeding, premenstrual syndrome and the like due to luteal phase defect with a significantly improved therapeutic effect.

Abstract: An intravaginal drug delivery device comprising: a drug delivery device, and a therapeutically effective amount of a single active agent that is therapeutically effective for the treatment of endometriosis, wherein the drug delivery device delivers the single active agent directly to endometrial implants in women diagnosed with endometriosis, wherein the single active agent is selected from the group consisting of mifepristone and metabolites thereof.

Abstract: An antimicrobial polymer for use in contact lenses includes at least one antimicrobial monomer; and at least one other monomer selected from an acrylic monomer, a hydrophobic acrylic monomer, a hydrophilic acrylic monomer, a vinyl monomer and/or a collagen monomer.

Abstract: The METHODS, APPARATUSES AND SYSTEMS FOR INSTILLING STEM CELLS AND PHARMACEUTICALS INTO THE HUMAN VENTRICULAR SYSTEM (hereinafter “Ventricular Stem Cell System” or “VSCS”) disclosed herein provide safe and effective techniques for obtaining stem cells and instilling any type of stem cell or pharmaceutical agents into the human ventricular system for treatment of various diseases, including neurodegenerative diseases such as Parkinson's, Alzheimer's, Multiple Sclerosis, and others.

Abstract: The present disclosure provides a method for lifting submucosal or mucosal tissues in a patient, comprising administrating to the tissues an effective amount of a thermosensitive gel composition comprising Poloxamer-407. A method for performing an endoscopic procedure, a method for submucosal or mucosal resectioning, a method for performing an endoscopic ultrasound procedure, and a method for performing a polyp removal are also provided.

Abstract: A topical liquid grip lotion is disclosed in multiple embodiments. The topical liquid grip lotion includes embodiments which are longer lasting that prior products and also includes embodiments which are formulated to provide relief from temporary user discomfort or pain that may associated with the underlying activity by the user in areas where the topical lotion is applied. The certain embodiments of the liquid sports grip aid/liquid hand chalk include about 1% lidocaine. In addition to increasing the amount of time of use per application, these embodiments provide a pain reducing agent which can be exceptionally useful for athletes and individuals who experience soreness in their hands, feet, and body when training. Alternative embodiments include formulations are substantially non-irritating due to the topical use of the product, and not intended for ingestion. It is unique that as not only do the embodiments immediately dry hands, feet, and body but can reduce soreness.

Abstract: The invention relates to pharmaceutical compositions for parenteral administration comprising a) Ibuprofen or a pharmaceutically acceptable salt thereof, and b) a phosphate buffer.

Abstract: Slurries comprise liquid water, about 2% to about 70% ice by volume, and one or more additives affecting flowability and/or tonicity of the slurry. Solutions for making a slurry comprise liquid water and one or more additives affecting flowability of the slurry. Flowability of the slurry relates to ice particles capable of flowing through a cannula, such as a needle. The slurry is suitable for injection into subcutaneous fat of a human subject for removal of adipose tissue.

Abstract: The present invention provides a pharmaceutical composition for the lubrication of joints, the pharmaceutical composition comprising a non-ionic tonicity agent comprising a polyol, and liposomes comprising at least one membrane comprising at least one phospholipid (PL) selected from a glycerophospholipid (GPL), said GPL having two C12-C18 hydrocarbon chains, being the same or different, and sphingomyelin (SM) having a C12-C18 hydrocarbon chain, the pharmaceutical composition being essentially free of an additional pharmaceutically active agent, wherein the at least one membrane has a phase transition temperature in the range of about 20° C. to about 39° C. and the joint has a joint temperature which is above the phase transition temperature.