Abstract: An embodiment of the present disclosure provides an adjustable couch that can be mounted on a medical couch, the adjustable couch comprising: a first couch provided with a fixing means to be fixed to the medical couch; and a second couch disposed on the first couch and provided with a rotating-coupling means to be coupled rotatably about a first axis perpendicular to an upper surface of the first couch.

Abstract: Various methods and systems are provided for stationary CT imaging. In one embodiment, a modular imaging system comprises a plurality of distributed x-ray units releasably coupled to a plurality of detector arrays, with the plurality of distributed x-ray units and the plurality of detector arrays forming a self-supporting structure including a central opening shaped to receive a subject to be imaged. The modular imaging system may image the subject without rotation of the distributed x-ray units or detector arrays around the subject.

Abstract: Various methods and systems are provided for stationary computed tomography (CT) imaging. In one embodiment, a stationary CT system includes one or more detector arrays extending around at least a portion of an imaging volume, a stationary distributed x-ray source unit comprising a plurality of emitters including a first set of emitters configured to operate at a first voltage and a second set of emitters configured to operate at a second voltage, different than the first voltage, and a source controller for triggering the first set of emitters for acquiring first projection data by the one or more detector arrays and triggering the second set of emitters for acquiring second projection data by the one or more detector arrays, the first projection data and the second projection data usable to reconstruct one or more basis material composition images or monochromatic images of an object within the imaging volume.

Abstract: The present technology relates to a circular-arc-shaped hybrid C-profile for a C-arm X-ray apparatus, said profile having a lightweight profile as the main body and a steel profile as a support profile for a bearing unit, the lightweight profile and the steel profile being connected to one another by connecting means.

Abstract: Various methods and systems are provided for stationary CT imaging. In one embodiment, an imaging system comprises a chamber shaped to enclose a subject to be imaged, a support surface disposed within the chamber and shaped to maintain the subject in an upright position, and an annular imaging unit encircling the chamber and having a fixed angular orientation to the chamber, the annular imaging unit including a distributed x-ray unit and a detector array arranged opposite to each other across the chamber. The imaging system may image the subject without rotation of the annular imaging unit.

Abstract: Provided is an X-ray imaging system capable of performing X-ray imaging quickly. The X-ray imaging system is provided with: an X-ray tube device including a cathode and an anode, the X-ray tube device being capable of performing X-ray imaging by irradiating an imaging target with X-rays in a state of rotating the anode; a light irradiation device including a collimator defining an X-ray irradiation range of the X-rays with respect to the imaging target, a visible light irradiation unit for emitting visible light to the imaging target and a light irradiation operation unit for performing an operation for making the visible light irradiation unit in the light irradiation state; and a controller for controlling operations of the X-ray tube device and the light irradiation device. The controller rotates the anode at an imaging possible rotation speed capable of performing X-ray imaging when the light irradiation operation unit is operated.

Abstract: When a first-stage push-button switch of an operation unit (2) is pressed, an X-ray imaging control unit (72) transmits a signal A for starting voice guidance to a signal output unit (73) for a voice guidance unit as well as a signal B for starting preparation of X-ray imaging to an X-ray tube control unit (71). At this time, when the pushing operation of the push-button switch is performed, the X-ray imaging control unit (72) immediately transmits the signal A for starting the voice guidance to the signal output unit (73) for the voice guidance unit but transmits the signal B for starting the X-ray imaging after a time t1 has elapsed. The time t1 is a time calculated by subtracting a time t3 required for preparing an X-ray tube (42) for performing X-ray imaging from a time t2 required for the voice guidance.

Abstract: After an operator presses a practice mode execution start switch displayed on a touch panel liquid crystal display unit in an operation unit (2) or a touch panel liquid crystal display unit in an operation unit (41) to shift an imaging mode to a practice mode, when the operation unit (2) or the operation unit (41) of the imaging unit is operated, the signal from the X-ray imaging control unit (72) is transmitted to the voice guidance output control unit (52) in a voice guidance unit (5) via a signal output unit for a voice guidance unit (73). The voice guidance output control unit (52) in the voice guidance unit (5) transmits a signal for outputting voice guidance to a speaker (51). As a result, the same voice as a voice when performing the serial imaging is output from the speaker (51). Thus, a subject can execute the practice of a breathing method or the like.

Abstract: A CPU specifies whether or not a structure of a specific shape having transmittance of radiation lower than a patient is present in an imaging region of a radioscopy apparatus that captures a radiographic image with the radiation emitted from a radiation source, based on the specific shape. The CPU performs control for setting an imaging region excluding the structure as the imaging region before irradiation of the radiation is performed from the radiation source in a case where the structure is present.

Abstract: The present invention discloses a method and a system of vertebral compression fracture detection. The method of vertebral compression fracture detection includes: recombining a plurality of anatomical images captured in at least a spine segment of a target individual into a 3D image; using a multi-planar reconstruction method to reformat the 3D image to obtain at least one sagittal reformatted image; using a classification model to determine whether the sagittal reformatted image covers the middle section of the vertebral column or not; using a vertebral detection method to detect each vertebral body in the sagittal reformatted image covering the middle section of the vertebral column; using a keypoint localization method to localize a plurality of keypoints of each vertebral body which was detected in the sagittal reformatted image; evaluating the compression fracture grade of each vertebral body in the sagittal reformatted image.

Abstract: A body thickness conversion unit converts a body thickness from a distance image imaged by a distance measurement camera to acquire the body thickness. A strength setting unit sets strength of noise reduction processing to a radiographic image to be stronger as the body thickness is thicker. A radiographic image acquisition unit acquires the radiographic image output from a radiation detector in radioscopy. A noise reduction processing unit executes the noise reduction processing on the radiographic image with the strength set by the strength setting unit.

Abstract: Various methods and systems are provided for stationary CT imaging. In one embodiment, an imaging system comprises a stationary distributed x-ray source unit comprising a plurality of emitters positioned to emit x-ray beams through the imaging volume, one or more detector arrays extending around at least a portion of an imaging volume, each detector array comprising a plurality of detector elements, each detector element configured to receive x-ray beams from more than one emitter, and an anti-scatter device configured to be positioned between one or more emitters of the plurality of emitters and an object in the imaging volume.

Abstract: Various methods and systems are provided for stationary CT imaging. In one embodiment, a method for an imaging system includes activating an emitter of a plurality of emitters of a stationary distributed x-ray source unit to emit an x-ray beam toward an object within an imaging volume, where the x-ray source unit does not rotate around the imaging volume, receiving the x-ray beam at a subset of detector elements of a plurality of detector elements of one or more detector arrays, sampling the plurality of detector elements to generate a total transmission profile, an attenuation profile, and a scatter measurement, generating a scatter-corrected attenuation profile by entering the total transmission profile, the attenuation profile, and the scatter measurement as inputs to a model, and reconstructing one or more images from the scatter-corrected attenuation profile.

Abstract: Systems and methods for digital radiography are provided. The method may be implemented on the implemented on a DR system including an imaging device and a computing device. The computing device may include at least one processor and at least one storage device. The method may include directing multiple dose sensors to detect a dose of radiation rays emitted from a radiation source of the imaging device. The multiple dose sensors may correspond to multiple imaging detectors, respectively. The method may also include determining the dose of the radiation rays. The method may further include directing, based on the dose of the radiation rays, at least one imaging detector of the multiple imaging detectors to proceed to detect the radiation rays for generating an image of a target object to be examined.

Abstract: A radiation imaging system is provided. The system comprises a radiation imaging apparatus including a plurality of pixels for acquiring radiation image data and a detection unit for performing exposure control during radiation irradiation, and a radiation control apparatus configured to control a radiation source that irradiates radiation to the radiation imaging apparatus. The radiation imaging apparatus and the radiation control apparatus transmit signals that relate to exposure control by wireless communication. The radiation imaging apparatus, in a case where an irradiation stop signal indicating that radiation irradiation has been stopped is not received from the radiation control apparatus after a signal instructing to stop radiation irradiation has been transmitted to the radiation control apparatus and until a first time interval has elapsed, transmits a signal instructing to stop radiation irradiation to the radiation control apparatus again.

Abstract: A body thickness conversion unit converts a body thickness from a distance image imaged by a distance measurement camera to acquire the body thickness. A setting unit sets a gradation transformation function for use in gradation transformation processing to a radiographic image corresponding to the body thickness. A radiographic image acquisition unit acquires the radiographic image output from a radiation detector in radioscopy. A gradation transformation processing unit starts the gradation transformation processing with the gradation transformation function set by the setting unit.

Abstract: An x-ray system comprising: at least two system statuses; at least one system status value associated with at least one of the at least two system statuses; at least one trigger; at least one activation parameter associated with the at least one trigger; the at least one activation parameter is selected from the group consisting of: (a) at least one system status value; (b) at least one system status value with a tolerance; and (c) at least one range of system status values; at least one set associated with the at least one trigger, the at least one set comprises at least one system status parameter, the at least one system status parameter comprises at least one of: (1) a system status value; (2) a system status value with a tolerance; and (3) a range of system status values; and wherein the system status is changed according to the set upon activation of the at least one trigger.

Abstract: Methods, devices and systems for predicting non-clinical, undiagnosed conditions through audio data related to intestinal sounds of a patient or subject, wherein the methods, devices and systems utilize machine learning algorithms, and predicting the likelihood of in vivo impairment relative to the identified spectral events.

Abstract: The present invention provides a stethoscope head switchable between a digital mode and a conventional mode. The stethoscope head comprises a housing, a chestpiece, a switching mechanism, a microphone, a speaker, and a first power switch. The microphone is configured for receiving acoustic signals from the chestpiece. The speaker is configured for playing the acoustic signals received by the microphone. The first power switch is configured to be engaged by the switching mechanism. The switching mechanism is configured for switching the stethoscope head between the digital mode and the conventional mode when engaged by the first power switch.

Abstract: An ultrasonic imaging system and an imaging method. The imaging method comprises: transmitting a divergent ultrasonic beam to a scanning object, and scanning the scanning object with the divergent ultrasonic beam (S11); a self-scanning object receiving an echo of the divergent ultrasonic beam, and obtaining divergent ultrasonic echo signals by means of beam synthesis (S12); obtaining blood flow velocity vector information of the scanning object according to the divergent ultrasonic echo signals (S13); and displaying the blood flow velocity vector information of the scanning object (S14). Using a divergent ultrasonic beam to perform blood flow imaging can ensure that there is a sufficiently large scanning area for covering a scanning object, thereby achieving ultrasonic blood flow imaging at a high frame rate.

Abstract: A device and method for directing a cannula toward a target location under a patient's skin. The device is handheld and the device operations may be automated. The device includes an imaging probe for imaging the target location, a positioning unit for manipulating a cannula towards the target location, and a processor. The processor receives imaging data from the imaging probe, cannula pose data from at least one cannula position sensor, and device pose data from at least one device position sensor. The target location is identified from the imaging data, and a trajectory for manipulating the cannula towards the target location is determined based on the imaging data, the cannula pose data, and the device pose data. The processor may determine that the trajectory becomes misaligned with the target position, and may update to a corrected trajectory based on the imaging data, cannula pose data, and the device pose data.

Abstract: A device and system for and methods of using an ultrasound probe housing containing ultrasound probes configured to produce images inside the body of a patient for procedures requiring needle or probe insertion. The ultrasound probe housing can be configured with a guide channel cut-out or aperture between the ambient side and body side of a patient. A needle guide assembly may be pivotally connect internal to the guide channel cut-out or aperture of the ultrasound probe housing at a pivot point such that during use the needle enters the patient through the needle guide assembly within the ultrasonic probe housing so that the needle can be visualized by the ultrasonic probes in real time. The ultrasound probe housing may also provide an adhesion or suction quality to the body side of the device to facilitate aspects of the invention.

Abstract: The present invention relates to a monitoring apparatus for monitoring an ablation procedure. The monitoring apparatus comprises an ultrasound signal providing unit for providing an ultrasound signal that depends on received echo series of an object that is ablated. The monitoring apparatus further comprises an ablation depth determination unit for determining an ablation depth from the provided ultrasound signal. The ablation depth can be determined directly from the ultrasound signal and is an important parameter while performing an ablation procedure. For example, it can be used for determining the progress of ablation within the object and for determining when the ablation has reached a desired progression.

Abstract: Embodiments provide an ultrasound treatment system. In some embodiments, the system includes a removable transducer module having an ultrasound transducer. In some embodiments, the system can include a hand wand and a control module that is coupled to the hand wand and has a graphical user interface for controlling the removable transducer module, and an interface coupling the hand wand to the control module. The interface may provide power to the hand wand or may transfer a signal from the hand wand to the control module. In some embodiments, the treatment system may be used in cosmetic procedures on at least a portion of a face, head, neck, and/or other part of a patient.

Abstract: Methods and apparatus for treating a patient. The method includes acquiring a plurality of radio frequency (RF) signals with an ultrasound transducer, each RF signal representing one or more return echoes from a scan line of a pulse-mode echo ultrasound scan. A position of the ultrasound transducer corresponding to each of the acquired RF signals is determined, and a plurality of contour lines generated from the plurality of RF signals. The method estimates a 3-D shape and position of an anatomical feature, such as a joint of patient based on the generated contour lines and corresponding ultrasound transducer positions. An apparatus, or computer includes a processor and a memory with instructions that, when executed by the processor, perform the aforementioned method.

Abstract: In a transcatheter treatment support technique using a combination of a guide wire equipped with a photoacoustic technique and an ultrasonic imaging device, the ultrasonic imaging device estimates a front edge position of the guide wire using a difference between arrival times of photoacoustic waves arriving at an array of elements configuring an ultrasonic probe or a change of an image of the photoacoustic generation source, which depends on a distance of the photoacoustic generation source from an imaging region, and grasps a relationship between an imaging position and the front edge position of the guide wire using the estimation result. This enables visually grasping a relationship between a region (imaging region) from which an image is able to be obtained with reflective waves from a biological body with use of the ultrasonic probe and an insertion object present outside the region, particularly, the front edge of the guide wire.

Abstract: A combination of an ultrasonic scanner and an omnidirectional receive transducer for producing a two-dimensional image from received echoes is described. Two-dimensional images with different noise components can be constructed from the echoes received by additional transducers. These can be combined to produce images with better signal to noise ratios and lateral resolution. Also disclosed is a method based on information content to compensate for the different delays for different paths through intervening tissue is described. The disclosed techniques have broad application in medical imaging but are ideally suited to multi-aperture cardiac imaging using two or more intercostal spaces. Since lateral resolution is determined primarily by the aperture defined by the end elements, it is not necessary to fill the entire aperture with equally spaced elements. Multiple slices using these methods can be combined to form three-dimensional images.

Abstract: The present disclosure describes system, application, and/or methods for enabling operation of a transducer probe with a medical imaging device. An example method includes the steps of retrieving a user identification code assigned to a user associated with an imaging device, retrieving a transducer identification code of a transducer probe from a memory of the transducer probe responsive to connecting the transducer probe to the imaging device, generating a temporary digital key based on the user identification code and the transducer identification code, retrieving a stored digital key from the memory of the transducer probe, verifying an association of the transducer probe including comparing the stored digital key with the temporary digital key, enabling operation of the transducer probe with the imaging device if the stored digital key matches the temporary digital key.

Abstract: An ultrasound transducer includes: a flexible board configured to receive and output an electrical signal through a signal line; a plurality of piezoelectric devices that are electrically connected to the board and are aligned in a row, each piezoelectric device being configured to transmit and receive an ultrasound wave; a plurality of leads extending the signal line and protruding from an end portion of the board, each lead being electrically connected to the piezoelectric device in a curved manner; and a plurality of sheets that are arranged to prevent the leads from being in contact with each other, each sheet being provided on the lead and having an insulation property.

Abstract: A first-order estimation method of shear wave velocity, includes the steps of demodulating entry data, and obtaining a complex angle value, matrix average, offset matrix, displacement matrix and shear wave velocity. According to the method, the main contour of the displacement curve is extracted by the quadrature decomposition of matrix, thereby improving the signal quality of the shear wave estimation. Unlike conventional method which needs estimating twice, the shear wave displacement curve can be estimated directly to reduce estimation errors and improve estimation efficiency.

Abstract: An ultrasonic diagnostic apparatus generates an ultrasonic image of a subject by using an ultrasonic probe, and the ultrasonic diagnostic apparatus includes: a transducer unit that is arranged in the ultrasonic probe and performs transmission and reception of ultrasonic waves; a stepping motor that is arranged in the ultrasonic probe and moves the transducer unit; a motor controller that sends a drive signal of a microstep drive method to the stepping motor; an encoder that is arranged in the ultrasonic probe, detects rotational motion of the stepping motor, and generates a detection signal having a pulse train shape depending on an amount of rotational displacement per unit time of the stepping motor; and a position data generator that generates high-resolution position data in which resolution of position data of the transducer unit obtained from the detection signal is increased.

Abstract: An ultrasound control unit (10) is for coupling with an ultrasound transducer unit (12). The control unit is adapted to control a drive configuration or setting of the transducers of the transducer unit, each drive setting having a known power consumption level associated with it. The control unit includes a control module (20) adapted to adjust the drive setting from a first setting to a second setting, the second having a lower associated power consumption that the first. The second setting is tested by an analysis module (16), the analysis module adapted to determine a measure of reliability of ultrasound data acquired by the transducer unit, for the purpose of deriving at least one physiological parameter, when configured in the second setting. The second setting is only used if its determined reliability passes a pre-defined reliability condition.

Abstract: An exhaled breath condensate (EBC) collection device comprising two adjacent parts foldable together and apart from each other, a condensation zone to condense exhaled breath from a subject, the condensation zone being a third part provided between the two adjacent parts and connectable to cooling means arranged in each of the two parts being in cooling relationship with the condensation zone. There is also provided a method for detecting antigens or antibodies to the antigens, the method comprising collecting EBC from a subject using the EBC collection device, performing immunochromatographic testing (ICT) of the collected exhaled breath condensate, and interpreting the immunochromatographic testing results as follows: if the immunochromatographic testing results are positive, the antigens or antibodies to the antigens are detected, or if the immunochromatographic testing results are negative, the antigens or antibodies to the antigens are not detected.

Abstract: The invention relates to a kit (1) for the sampling of biological liquid in particular urine comprising: a flexible accumulator (2) of biological liquid adapted to collect the liquid comprising at least one liquid absorbing layer (10) and at least one support layer (11) attached thereto; at least one closed recipient (3) comprising a tubular container (5) with a tubular sidewall portion (6) and a bottom portion (7) forming an elongated tubular cavity (9) and a closing lid (5) sealingly connected to the sidewall portion (6); wherein the accumulator (2) is configured for being inserted in the tubular cavity (9) of the container, wherein the recipient (3) comprises holding means (12) configured for maintaining the accumulator in position in the recipient and distant from the bottom portion (7) of the container.

Abstract: This document describes devices for in vivo drug testing in the brain. This document also describes implantable devices for long-term drug delivery to the brain parenchyma, and for access to biomarkers from the parenchyma.

Abstract: Methods and techniques for obtaining enriched cell samples from an organ in a subject using an ultrasound contrast agent and insonating. Contiguous fragments of epithelia are obtained which are useful for subsequent histological analysis and for informing therapy and other medical considerations.

Abstract: Provided herein, in some embodiments, are breakable swabs for sample collection. In some embodiments, the swabs may be used in rapid diagnostic tests to detect one or more target nucleic acid sequences (e.g., a nucleic acid sequence of one or more pathogens). In some embodiments, the pathogens are viral, bacterial, fungal, parasitic, or protozoan pathogens, such as SARS-CoV-2 or an influenza virus. The swab may include a stem portion for handling and a head portion for collecting and/or holding a sample. After sample collection, the head portion may be inserted into a reaction tube or any other sample-receiving device. The stem portion of the swab may then be separated or detached from the head portion along a breakable portion.

Abstract: A robot-assisted approach for transrectal ultrasound (TRUS) guided prostate biopsy includes a hands-free probe manipulator that moves the probe with the same 4 degrees-of-freedom (DoF) that are used manually. Transrectal prostate biopsy is taken one step further, with an actuated TRUS manipulation arm. The robot of the present invention enables the performance of hands-free, skill-independent prostate biopsy. Methods to minimize the deformation of the prostate caused by the probe at 3D imaging and needle targeting are included to reduce biopsy targeting errors. The present invention also includes a prostate coordinate system (PCS). The PCS helps defining a systematic biopsy plan without the need for prostate segmentation. A novel method to define an SB plan is included for 3D imaging, biopsy planning, robot control, and navigation.

Abstract: A collapsible medical device and methods for deploying the same are provided. The medical device includes a tubular metal fabric, which includes a plurality of braided metal strands and a proximal end and a distal end, the tubular metal fabric having a collapsed configuration for delivery and an expanded preset configuration for creating an occlusion of an opening. In the expanded preset configuration, the device has two expanded disk portions and a central portion, a first expanded disk portion and the central portion connected by a first reduced diameter portion, and a second expanded disk portion and the central portion connected by a second reduced diameter portion. Each of the first and second reduced diameter portions is smaller in diameter than both the two expanded disk portions and the central portion, and each of the first and second reduced diameter portions is recessed into the central portion.

Abstract: A collapsible medical device and associated methods of occluding an abnormal opening in, for example, a body organ, wherein the medical device is shaped from plural layers of a heat-treatable metal fabric. Each of the fabric layers is formed from a plurality of metal strands and the assembly is heat-treated within a mold in order to substantially set a desired shape of the device. By incorporating plural layers in the thus-formed medical device, the ability of the device to rapidly occlude an abnormal opening in a body organ is significantly improved.

Abstract: A tissue specimen retrieval bag assembly includes a tissue specimen bag having an open proximal end and a closed distal end, the proximal end including a cuff defined therein and extending therearound. A flexible bag brim is disposed within the cuff, the flexible bag brim transitionable between a first, collapsed configuration and a second, expanded configuration. The flexible bag brim includes a D-Shaped cross section configured to facilitate both furling the tissue specimen bag onto itself around the bag brim when the bag brim is disposed in the second, expanded configuration and securing the tissue specimen bag in a desired furled configuration. The flexible bag brim defines a cavity therein configured to facilitate compression thereof and to facilitate handling of the bag brim by a surgical instrument.

Abstract: A steerable instrument has a proximal end and a distal end, a steering device (168), and a tubular body (18) extending in a longitudinal direction from said proximal end to said distal end. The tubular body (18) has an intermediate flexible zone (12a) and a distal deflectable zone (17) and a tube element made from a metal. The tube element has a first slotted structure (74) in the flexible zone (12a) and a second slotted structure (72; 106; 136; 156) in the deflectable zone (17). The tubular body (18) has tangential rotation blocking elements which form cable channels (96; 97; 146; 152), each cable channel (96; 97) accommodating one of a plurality of cables (90). The cables (90) are connected at the proximal end to the steering device (168) and at the distal end to the deflectable zone (17) to allow deflection of the deflectable zone (17) by the steering device (168).

Abstract: A powder spray device includes a funnel member, a first three-way joint, an air-current supply tube, a discharge tube, a vibration motor, a bypass air-current tube, and a switching mechanism. The first three-way joint has a first opening connected to an outlet at a lower end of the funnel member. The air-current supply tube and discharge tube are respectively connected to second and third openings of the first three-way joint. The vibration motor is fixed onto an outer surface of a funnel body of the funnel member. The bypass air-current tube branches off from the air-current supply tube and is connected to the discharge tube. The switching mechanism switches from and to standby state, in which compressed gas is sent only through the bypass air-current tube, to and from spray-coating state, in which compressed gas is sent out through the air-current supply tube, and also through the bypass air-current tube.

Abstract: A sheet applying device, a sheet applying system, and a sheet applying method are provided. A first sheet applying system 10 mainly includes a first sheet applying device 11 and a sheet cartridge 900. The first sheet applying device 11 mainly includes a first supporter 200 and a holder 500. The first supporter 200 mainly includes a first support shaft 210a, a second support shaft 210b, a first swing mechanism 220, a support cover 211, and a handle 300. The first support shaft 210a and the second support shaft 210b have straight cylindrical bar shapes and movably extend in parallel to each other from a proximal end side of the first sheet applying system 10 toward a distal end side of the first sheet applying system 10, in other words, in a longitudinal direction of the first supporter 200.

Abstract: The present invention provides an instrument assembly that is expandable in steps for providing precise measurement of bone gap and distraction of bone in a controlled manner. It discloses a tool performing expandable Bi-Surface Mechanism to expand a bi-compartmental structure. The disclosed system is equipped with two active surfaces (Bottom base and a top plate) between which a force is applied to move the surfaces in relation to each other for providing precise measurement of bone gap and distraction of bone in a controlled manner. Additionally, the control mechanism of the present invention includes applying direct and/or measured/graduated separation force between the two surfaces and able to deliver haptic and sensor-based feedback to the surgeon for the critical ligament tensioning and balancing aspects of the procedure.

Abstract: The present disclosure relates to antisense oligonucleotides, which target CAMK2D mRNA in a cell, leading to reduced expression of CAMK2D protein. Reduction of CAMK2D protein expression is beneficial for the treatment of certain medical disorders, e.g., cardiovascular-related diseases or disorders.

Abstract: Surgical constructs and methods of use for tissue repair, in which the surgical constructs include a soft fixation device formed of flexible material, the soft fixation device having a head portion formed of a bunching material for anchoring the soft fixation device in a bone tunnel, and a tail portion for pulling the soft fixation device into the bone tunnel. The surgical constructs include one ore repair flexible strands coupled to the head portion of the soft fixation device for engaging tissue to be repaired.

Abstract: A system and method for repairing soft tissue tears such as meniscal tears. The anchor system has a first implant connected to a length of suture. The length of suture is folded such that a tensioning limb extends from the first implant and a locking limb extends from the first implant. The anchor system also includes a second implant fixed to the locking limb and an adjustment mechanism in the length of suture between the first implant and the second implant. The tensioning limb is passed through the adjustment mechanism. This creates an adjustment loop in the length of suture extending from the adjustment mechanism through the first implant. The adjustment loop is a one-way adjustable loop for moving the first implant and second implant in relative position to each other.

Abstract: Systems and methods of placing one or more suture loops into tissue, such as the base of the tongue, are described. A system can include a variable-thickness suspension line for suspending tissue, including a suture having a first thickness dimension; an elastomer surrounding a portion of the suture and defining a central segment of the suspension line having a second thickness dimension greater than the first thickness dimension, and at least one transition zone extending from the central segment of the suspension line to a lateral end of the suspension line, the transition zones having a thickness dimension that tapers from the second thickness dimension to the first thickness dimension.

Abstract: An anchoring system includes an anchor including an anchor body and a distal member located at a distal end of the anchor body, the distal member having a suture receiving aperture; and an implant delivery device, comprising: a cannulated outer shaft, the cannulated outer shaft configured to engage a proximal end of the anchor body for driving the anchor into a bore; and an inner shaft slidably received in the cannulated outer shaft, wherein a distal end of the inner shaft is extendable distally beyond a distal end section of the cannulated outer shaft such that, when the cannulated outer shaft is engaging the proximal end of the anchor body, the distal end of the inner shaft is extendable through the anchor body to a distance beyond the distal end of the anchor body to engage a suture located within the suture receiving aperture, wherein the anchoring system is configured such that the suture can be tensioned at a location within the bore distal from the anchor body before the anchor body is implanted within