Abstract: The present invention provides a guidewire adjuster and a delivery-system control handle provided with the guidewire adjuster. The guidewire adjuster includes a support mechanism which has a lumen for a guidewire to extend therethrough; and a driving mechanism for driving the guidewire to move back and forth in the lumen. The guidewire adjuster is able to drive the guidewire to move with respect to a sheath of the delivery system. The support mechanism is connected to the control handle of the delivery system and forms a lumen for accommodating the guidewire. A proximal end of the sheath together with the stent can be driven to move upwardly, due to the relative movement between the guidewire and the sheath of the delivery system. Therefore, the position of the stent can be adjusted by advancing the guidewire forward when the stent has been deployed at a lower position than expected.

Abstract: Mechanisms are provided to implement an intraoral control mechanism that allows a user to control an operation of a computer system or an electronic device. The intraoral control mechanism detects a strain based on a tongue of a user moving a control mechanism away from a fixed position; transduces the detected strain into a control signal; amplifies an amplitude of the control signal thereby producing an amplified control signal; converts the amplified control signal to a digital input signal; modulates the digital input signal onto a transmission frequency wave; and transmits the digital input signal to the computer system. The computer system may then either execute the digital control signal on the computer system itself to perform an operation or transmit the digital control signal to the electronic device so as to operate as indicated by the digital control signal. The digital input signal is saved for characterization of the user.

Abstract: An intragastric weight-loss device is disclosed. The device includes a proximal occlusion member comprising a spiral structure, a bridging member, and a distal occlusion member. The spiral structure can be configured to spiral into a bulbous shape when the proximal occlusion member is delivered into the stomach. The bridging member can extend from the proximal occlusion member. The distal occlusion member can be coupled to a distal end of the bridging member. The proximal occlusion member can be configured to intermittently obstruct a pyloric valve of a patient such that passage of food through the pyloric valve is slowed.

Abstract: An anatomical ring device for attachment to a penis includes a closed ring body defining an interior opening that is shaped and sized to receive a penis. The ring body may include two or more high-stretch sections separating two or more low-stretch sections of the ring body. The low-stretch sections may include a material that is substantially less stretchable than a material that comprises the high-stretch sections. The low-stretch sections may include two or more stiffeners disposed in the ring body. The high-stretch sections may include areas of the ring body that are situated between the stiffeners.

Abstract: Cosmetic method and apparatus are provided that can provide cooling and/or freezing of skin tissue proximal to the skin surface to generate an appearance of lightening or reduced pigmentation in the skin. The skin can be cooled to a temperature of less than about ?5 degrees Celsius for a duration of about one minute or less, using a plurality of cooled contact surfaces, each having a width between about 2 mm and about 20 mm. A cooling arrangement can be provided to provide controlled heat removal from the skin tissue being treated. A sensor can optionally be provided to detect freezing of tissue proximal to the cooled surfaces.

Abstract: A heating mat that, by making use of a multilayered structure, is able to provide therapeutic benefits to a user. The heating mat has a heating layer, PEMF emitters, and a primary therapeutic layer. The primary therapeutic layer uses therapeutic materials that facilitate treatment. The heating layer functions as a flexible heating element for the heating mat. The PEMF emitters are devices which generate pulses of EM energy that are known to have therapeutic properties. The PEMF emitters is mounted adjacent to a first face of the heating layer. The primary therapeutic layer is mounted adjacent to a second face of the heating layer, opposite to the PEMF emitter.

Abstract: Disclosed is a surgical instrument directed to phacoemulsification for cataract eye surgery. The instrument generally includes a hollow titanium needle extending from a vibration generating handpiece. Together, the hollow needle and handpiece form an aspiration pathway to suck cataractous debris from an eye. A piezoelectric transducer in the handpiece generates both high and low ultrasonic frequency vibrations that rings the needle. The low frequency produces a node-free standing wave along the needle and the high frequency produces a standing wave along the needle with a node of minimum amplitude along the needle. Both frequencies produce a high anti-node at the needle's tip. The low frequency causes higher cavitation for emulsifying the cataract and the high frequency facilitates fragmentation of the cataract with a low heat portion of the needle at the eye incision point. The placement of the node along the needle can be tailored by way of a tapered section in a step horn region of the handpiece.

Abstract: An ocular implant including an intraocular pressure sensor and having an inlet portion and a Schlemm's canal portion distal to the inlet portion, the inlet portion being disposed at a proximal end of the implant and sized and configured to be placed within an anterior chamber of a human eye, the Schlemm's canal portion being arranged and configured to be disposed within Schlemm's canal of the eye when the inlet portion is disposed in the anterior chamber.

Abstract: Systems and methods for delivering multiple ocular implants to reduce intraocular pressure are disclosed. The ocular implants can be implanted at multiple sites within a single human eye without requiring removal of the delivery apparatus from the eye. A system for delivering multiple ocular implants can include at least two implants preloaded within a delivery device and configured to be implanted within the eye, a metering device configured to transfer energy to the implants for delivery at selected locations within the eye, wherein the metering device is configured to meter a variable amount of energy for each implant delivery event in the eye. The system can further include an injector mechanism configured to serially engage and drive each of the implants.

Abstract: Laser pulse modulation for laser corneal treatments is used to control the thermal energy imparted to the cornea. The optical energy of the laser pulses may be modulated to reduce or increase the thermal energy, depending upon an expected thermal load or a measured temperature at each position location of the cornea subject to laser treatment. The laser pulse modulation may involve pulse frequency modulation, pulse amplitude modulation, and pulse duration modulation.

Abstract: A sleep mask apparatus for use over a user's eyes. The sleep mask apparatus includes an opaque element having an inner surface and an opposing outer surface. The opaque element is sized and configured to extend across both of the user's eyes to mitigate the passage of light toward the user's eyes with the inner surface facing the user and the outer surface facing away from the user. A support element is coupled to the opaque element and includes a first support surface and an opposing second support surface. The inner surface of the opaque element is offset from the first support surface. The support element defines a peripheral margin extending around the opaque element, with the first support surface having an adhesive applied thereto at the peripheral margin to facilitate adhering of the support element to the user.

Abstract: A two-piece bandage is useful for treating wound on a patient. The bandage includes a boundary portion including a bottom surface comprising adhesive for attaching the boundary portion to skin of a patient, an open window in the middle of the boundary portion permitting one to view a wound through the open window, and a top surface. The top surface includes a first portion of the top surface surrounding the open window including a flat surface and a second portion of the top surface including an uneven surface. The bandage further includes a plurality of replaceable wound covering portions, each replaceable wound covering portion comprising a padded section comprising a material to dress the wound.

Abstract: An absorbent disposable article, such as a diaper, panty diaper, panty liner, sanitary napkin or incontinence device is disclosed. The article has a porous polymer-based structure obtainable by a process of: (a) depositing and photopolymerizing, layer-by-layer in accordance with a predetermined 3D model, an emulsion having an external continuous phase surrounding droplets of an internal phase having has one or more photopolymerizable monomers and/or oligomers and a photopolymerization initiator; and (b) removing the internal phase from the continuous polymer phase formed from the one or more photopolymerizable monomers and/or oligomers. The process produces a monolithic porous structure having three types of pores: (i) pores resulting from the location from which the internal phase was removed, (ii) pores interconnecting the pores according to (i), and (iii) pores as predetermined by the 3D model. The invention also relates to a method of making the article.

Abstract: The present disclosure relates generally to a wearable device, and more specifically to a wearable device for detecting biological events, monitoring health condition of an individual, and for providing automatic alerts and analytics reporting. An exemplary wearable device for monitoring health condition of an individual comprises a puck component attachable to the individual's clothing, wherein the puck component comprises a circuit of a moisture sensor; a strip component configured to be placed within the individual's clothing, wherein a proximal end portion of the strip comprises a pair of conductive pads, and wherein the pair of conductive pads is configured to interface with the circuit of the moisture sensor while the proximal end portion of the strip is enclosed within the puck via a coupling mechanism.

Abstract: A compressed groove point (16) where compressed grooves (12) formed bilaterally and symmetrically on both sides of a center line (CL) in a lengthwise direction of a sanitary napkin (1) or lines extended from center lines of the compressed grooves (12) intersect with each other at a position corresponding to a front end (31) of a intergluteal cleft of a wearer is formed, and a right and left pair of outline inflection points (17) is formed in an outline of a rear end of the sanitary napkin (1) formed into a bilateral and symmetric wavelike shape.

Abstract: A package formed of flexible polymeric film and having a line of weakness to facilitate opening of the package and to demarcate a package base and a package hood is disclosed. The package hood may be configured so as to serve as an effective package reclosure device whereby the package may be used to store the unused supply of articles following opening.

Abstract: A packaging body for absorbent articles which can further attract an attention of a user and can increase a desire of purchase of the user is provided. The packaging body for absorbent articles includes absorbent articles and a bag-shaped packaging sheet for packaging a plurality of absorbent articles. The packaging sheet includes a surface constituting an outer surface of the packaging body, and a back surface that constitutes an inner surface of the packaging body and comes into contact with the absorbent articles. The surface of the packaging sheet has a plurality of surface recesses formed so as to be recessed toward the back surface side and the back surface of the packaging sheet has a plurality of back surface recesses formed so as to be recessed toward the surface.

Abstract: Embodiments are disclosed of a method of controlling timing and/or dosage of a transdermal drug patch. For example, a control device operative to move the patch to one or more of a plurality of operational relationships with a skin of a patient, including being fully engaged with the skin, partially engaged with the skin, and disengaged with the skin. The device may include a roller that peels a patch on and off the skin. Optionally a convention patch is used. In some embodiments a patch and/or an adaptor has a mobile zone and an immobile zone. In some embodiments, an active surface of the patch fully contacts the skin in an engaged state. For example the patch may be attached to the device on a passive portion thereof.

Abstract: A patient transport apparatus for use with a vehicle, comprising a lift mechanism between a base and a support frame to move between an extended configuration defining a first distance and a retracted configuration defining a second distance. An interface generates a user signal. A sensor generates a sensor signal corresponding to force acting on the base relative to the support frame. A controller determines if the user signal corresponds to an extend or retract command; determines if the force acting on the base has exceeded a predetermined threshold value based on the sensor signal; drives the lift mechanism toward the extended configuration where the user signal corresponds to the extend command and toward the retracted configuration where the user signal corresponds to the retract command; and interrupts driving the lift mechanism to stop motion of the lift mechanism in response to the sensor signal exceeding the predetermined threshold value.

Abstract: A patient transport apparatus comprises a support structure. The support structure comprises a base, a frame, and a patient support surface to support a patient. The patient transport apparatus also includes a first and a second caster assembly respectively coupled to the support structure to facilitate movement of the support structure along a floor surface, with the first caster assembly comprising a first brake assembly and the second caster assembly comprising a second brake assembly. The patient transport apparatus also includes an actuator assembly operatively coupling the first and second brake assemblies, with the actuator assembly comprising a first and second actuator respectively operatively coupled to the first and second brake assemblies. The actuator assembly further comprises a cable assembly interconnecting the first and second actuator that places the operatively coupled first and second brake assemblies in the braked state or the unbraked state.

Abstract: A lift assist device preferably includes a pair of lift units and a battery. Each lift unit preferably includes a linear actuator, a lift projection, a top bracket and a bottom bracket. A screw sled extends from one side of the linear actuator. An end of a lift projection is secured to the screw sled. One end of the top bracket is attached to a top of the linear actuator. One end of a bottom bracket is attached to a bottom of the linear actuator. The top and bottom brackets will be different depending on whether they are attached to rollators, wheelchairs, motorized wheelchairs and motorized scooters. The lift assist device may be used to help lift a user from a chair adjacent the rollator, wheelchair, motorized wheelchair or motorized scooter, or when the user is seated in rollator, wheelchair, motorized wheelchair or motorized scooter.

Abstract: There is described methods of monitoring a patient on a bed. An exemplary method includes receiving one or more sensory outputs from sensors associated with the bed, analysing the one or more sensory outputs and determining a plurality of features of the patient therefrom, and receiving the plurality of patient features and determining a health assessment by inputting the patient features into a statistical model.

Abstract: The present invention discloses a turning air mattress, a turning air cell, and a control method for a turning air mattress. With structural arrangements of an upper portion and a lower portion of the turning air cell as well as inflation and deflation control, the turning air cell having an upper portion that is wider and a lower portion that is narrower can further assist a patient in body turning, enabling the patient to easily achieve a sufficient body turning angle, further reducing the risk of likeliness to pressure sores caused by the structure of the air mattress pressing against the body of the patient.

Abstract: In general, various surgical patient positioners and methods for using the same are provided. For example, a surgical patient support is provided for use during anterior hip replacement surgery. The surgical patient support can have a body support configured to receive an upper body of a patient thereon and one or more extremity supports configured to receive one or more patient extremities thereon.

Abstract: A patient aid assembly for a railed device having first and second associated rails in parallel relation, and an interconnecting member joining first and second mobile upper extremity support assemblies.

Abstract: A system for treating soft tissue of a patient. The system includes a treatment head and a computer portion. The treatment head includes a probe and an electrode operably coupled to the probe. The probe and electrode are configured to respectively deliver a mechanical force impulse and an electrical stimulation to the soft tissue when placed in operable contact with the soft tissue. The computer portion includes a CPU and is configured to coordinate the delivery of the mechanical force impulse and electrical stimulation relative to each other. The system is configured to sense a shockwave in the soft tissue of the patient, the shockwave resulting from the mechanical force impulse delivered to the soft tissue via the probe. The system is also configured to analyze a characteristic of the sensed shockwave and configure the electrical stimulation to be delivered to the soft tissue via the electrode based on the characteristic analysis of the sensed shockwave.

Abstract: An ingestible gastrointestinal capsule (GIC) for mechanically stimulating a segment of the gastrointestinal (GI) wall by alternately and repeatedly pressurizing, and/or vibrating it is provided. The GIC is programmed to being activated following a predefined time delay. The activated GIC agitates, shakes, rattles, jolts, vibrates and/or moves in a reciprocal expanding and contracting motion thereby mechanically stimulating the adjacent segment of the GI wall at a targeted location. Activation of the GIC may include a number of automatically accomplished partial activations, such as when the time elapsed from the moment of setting the GIC on equals a predefined time delay; when the mechanical load applied onto the GIC exceeds, and/or gets lower than a respective predefined level of mechanical load; when the ambient pH reaches a predefined level, or changes, and/or a temperature associated with the user reaches a predefined threshold. Agitation is accomplished by an agitation mechanism embedded in the GIC.

Abstract: System and method for providing remotely guided physical treatment are disclosed. A computing device is communicably coupled to a therapeutic robot and a remote guidance device. The computing device receives full-body images of a treatment subject. The computing device generates a plurality of key physical points for the treatment subject by identifying a three-dimensional human body template that corresponds to the shape and posture parameters of the treatment subject and fitting the identified first three-dimensional human body template to the full-body images of the treatment subject. The fitting causes adjustments to locations of the corresponding set of key physical points of the first three-dimensional human body template. The adjusted locations of the corresponding set of key physical points of the first three-dimensional human body template are provided to the guidance device as basis for a treatment procedure that is specified by the treatment guidance provider during the physical treatment session.

Abstract: An exercise device for stretching muscles, fascia and joints includes a rear base that transitions to a front nipple made from a solid and firm material. The device is attachable rigidly to a stationary structure such as a door jam in numerous different positions for use in a variety of exercises. The device may be attachable via a clamp unit that can be tightened laterally or other attachment means to attach to the door jam. The exercise device may be modular in form made from a plurality of pieces that are attachable to one another to form the device in a solid unitary structure.

Abstract: A securing device for securing an infusion appliance to an infusion container includes a first fastening element, which is designed in such a way that it is connectable to a fastening region of the infusion container, and a second fastening element, which is arranged at a distance from the first fastening element and which is designed in such a way that it is connectable to a fastening region of the infusion appliance. At least one connection element connects the first fastening element and the second fastening element to each other. The securing device can be used for medical infusion and transfusion arrangements.

Abstract: A vial adaptor comprises first and second housings coupled to each other, a sheath enclosing the first and second housings, and a spike disposed in the first and second housings. The first and second housings form a first chamber therein. The sheath and the first and second housings form therebetween a second chamber in air communication with the first chamber. The second housing is slidable relative to the first housing to cause the spike piercing through a front stopper to establish air and fluid communication with a vial attached to the vial adaptor, meanwhile to vary the volume of the first chamber and press the air into the second chamber. Upon a fluid being drawn from the vial, the air in the first and second chambers enters the vial to compensate the pressure reduction caused by the fluid drawn out to prevent fluid spillage or aerosolizing from the vial.

Abstract: Various aspects of the subject disclosure relate to a compounder system having a cartridge that includes fluid pathways controllable by valves of the cartridge. A pump component within the cartridge is actuable to move fluid through the controllable fluid pathways. The cartridge includes a needleless fluid port and a needleless vent port for fluid coupling to a vial via a vial puck. The vial puck includes corresponding needleless fluid and vent ports and a cannula. The cannula is extendible, by insertion of a protrusion on the cartridge into a shaft of the vial puck, into the vial to couple the vial to the needleless fluid and vent ports.

Abstract: Provided is a tablet guiding path adjusting apparatus that adjusts a tablet guiding path adjusting mechanism in the tablet cassette, comprising a rotor rotatably equipped within a cassette body and having a tablet guiding path for receiving at least one of tablets received within the cassette body and guiding to a discharging orifice of the cassette body; a partition member for entering the tablet guiding path and being located between a tablet at the lowest part and a tablet at the upper side thereof; and tablet guiding paths adjusting mechanisms configured to adjust at least either dimension of the depth and width of the tablet guiding path to the rotor; wherein the tablet guiding path adjusting apparatus engages with engaging parts of the tablet guiding path adjusting mechanisms to operate the tablet guiding path adjusting mechanism, and adjusts a dimension of the tablet guiding path in accordance with the shape or size of tablets received within the cassette body.

Abstract: Cosmetic stick containing: a) one or more UV filters, b) a Fischer-Tropsch wax with a solidification point of 80-85° C. (measured according to ASTM D 938) and a penetration at 25° C. of 0.4-0.9 mm (measured according to ASTM D 1321), the preparation being free from 3-(4-methylbenzylidene)-camphor, 2-hydroxy-4-methoxybenzophenone (INCI: Oxybenzone), 2-ethylhexyl 4-methoxycinnamate (INCI: Octyl Methoxycinnamate) and ethylhexyl-2-cyano-3,3-diphenylacrylate (INCI: Octocrylene).

Abstract: A solid state, oil gel composition for keratinous substance, such as skin, contains (a) at least one fatty acid-based gelling agent; (b) at least one polysaccharide fatty acid ester; and (c) at least one oil. An embodiment according to the present invention provides improved storage stability, morphological stability, and application property.

Abstract: Provided is a gel-type oil-in-water emulsion composition containing components A to F, in which A: at least one liquid oil which is selected from the group consisting of a hydrocarbon oil, an aliphatic ester and a silicone oil and a content of which is equal to or greater than 15% by mass with respect to a total amount of the gel-type oil-in-water emulsion composition; B: at least one nonionic surfactant which is selected from the group consisting of a saturated fatty acid glyceryl and a saturated fatty acid polyglyceryl and which has a Hydrophilic-Lipophilic Balance of equal to or smaller than 7; C: a sucrose saturated fatty acid ester; D: an ionic surfactant which has a saturated fatty acid residue as a hydrophobic group and a glutamic acid residue as a hydrophilic group; E: at least one surfactant having an unsaturated fatty acid residue; and F: water.

Abstract: An aqueous formulation for treating insects and fungal diseases on plants includes effective amounts of an HOCl-containing electrolyzed oxygenated aqueous solution, one or both of a food grade diatomaceous earth and a clinoptilolite zeolite, and one or more of a sodium magnesium fluorosilicate and a bentonite clay. The formulation, which is non-toxic to humans and pets, can be sprayed on the plants to kill insects and fungi and has a long dwell time to improve the effectiveness of the components of the formulation against insects and fungi. In particular, the formulation will kill bacteria, virus, mold, fungi, and may be used on food crops. The formulation also may be used as a plant and foliar cleaner and/or the formulation can be used to treat skin of a person to improve skin health.

Abstract: The present invention relates to hair care compositions comprising malodor reduction compositions and methods of using such hair care compositions. Such hair care compositions comprising the malodor control technologies disclosed herein provide malodor control without leaving an undesirable scent and when perfume is used to scent such compositions, such scent is not unduly altered by the malodor control technology.

Abstract: The present invention relates to hair care compositions comprising malodor reduction compositions and methods of using such hair care compositions. Such hair care compositions comprising the malodor control technologies disclosed herein provide malodor control without leaving an undesirable scent and when perfume is used to scent such compositions, such scent is not unduly altered by the malodor control technology.

Abstract: Described herein are methods of cleaning a tooth comprising administering a composition comprising a zinc amino acid halide complex to the oral cavity; and retaining the composition in the oral cavity for a time sufficient to form a precipitate.

Abstract: The invention relates to cosmetic formulations and new peptide related entities designed for the cosmetic treatment of the human skin. In more detail, the invention is related to peptides that target CD90 positive tissue cells and correspond to or derive from the partial sequence of erythropoietin (EPO) but do not substantially elicit a hematopoietic but a tissue regenerative and protective effect. In particular, the invention discloses EPO-derived tissue-protective peptides in functional relation to lipid structures and agents that trigger vasculature relaxation and promote transdermal transport of the polypeptide entities to the targeted skin cells.

Abstract: Tattoo removal is disclosed. In an example, a method for removing tattoo ink from skin or resolving a medical condition related to tattoo ink, includes applying a primary solution of beta glucan to a treatment area having tattooed skin. The primary solution stimulates the skin in the treatment area to enhance removal of the tattoo ink from the skin. The example method also includes coating the treatment area with a secondary solution. The secondary solution may have an absorbent material to draw in loose ink. The example method also includes disrupting a skin barrier in the treatment area by a needle or ablative device to improve penetration of at least one of the primary solution and the secondary solution.

Abstract: Disclosed are oral care compositions of phosphonate and sulfonate group containing polymer compositions that have targeted uses with divalent cations and surfaces having divalent cations. These compounds can be used to deliver anionic character to surfaces such as calcium hydroxyapatite.

Abstract: Described herein are personal care compositions comprising a stability control system comprising a non-ionic opacifier, and a cationic polymer. Methods of making and using the compositions are also described.

Abstract: To provide an acrylic silicone graft copolymer capable of effectively exerting a function in a composition for external application containing various oily components such as a natural oil, a hydrocarbon oil, ester oil and a silicone oil, and a composition for external application containing the acrylic silicone graft copolymer. A composition for external application including an acrylic silicone graft copolymer, which contains 2 to 25 mass % of a constitutional unit represented by formula (I), 55 to 85 mass % of a constitutional unit represented by formula (II) and 2 to 20 mass % of a constitutional unit represented by formula (III). wherein R1 is an alkyl group having 1 to 4 carbon atoms; R2 is an alkylene group having 2 to 10 carbon atoms; and n is an integer of 1 to 100.

Abstract: Disclosed herein are tooth whitening compositions comprising at least one hydrophobic polymer carrier; fumed silica; sorbitan sebacate behenate polymer; and at least one whitening agent, wherein the tooth whitening composition has a structural parameter such that G?/G? is greater than or equal to about 1. Also disclosed herein are methods of making a tooth whitening composition and methods of whitening the surface of a tooth.

Abstract: Aqueous nanoemulsions of carbamato-functional organopolysiloxanes prepared using a polyoxyethylene emulsifier having an HLB greater than 15 and at least 40 oxyethylene moieties and having a D50 particle size ?100 nm are transparent, stable, and useful in cosmetic compositions, particularly hair care compositions.

Abstract: An extended-release bio absorbable subcutaneous medicinal dosage delivery implant system includes an implant fabricated from a highly homogeneously mixed composition including a medicinal agent in combination with release controlling polymers which include poly (DL-lactide) and polycaprolactone. In one implementation for treating an opioid disease, the formulation composition includes naltrexone at 40 weight percent, poly (DL-lactide) in the range between 36 and 46.4 weight percent, and polycaprolactone in the range between 24 and 11.6 weight percent. In addition, in order to provide anti-biofouling quality and prevent foreign body adsorption/interaction with the material of the implant, polyethylene glycol is added in a preferred content of 2.0%. The manufacturing process includes hot melt extrusion and a mini jet based implant formation stage with the optimized process space were the temperature of the process ranges from 170° C.-180° C.

Abstract: Provided herein are methods and composition for trans-tympanic membrane delivery of therapeutic agents such as antimicrobial agents, anti-inflammatory agents, and anti-biofilm agents to the middle ear for rapid, localized treatment and prevention of diseases and conditions associated with a middle ear infection. In particular, provided herein are cationic, anionic, and polymer-based nanoparticles that provide a platform for delivery of therapeutic cargo, as well as cationic, anionic, and polymer-based nanoparticles compositions for rapid, localized delivery of therapeutic agents to the middle ear.

Abstract: The present invention provides a reproxalap ophthalmic solution, and methods of using the same for treating dry eye disease.