Abstract: In an example, a ventilator includes an outer container containing liquid, an inverted container submerged in the liquid to provide inverted container space between a closed top and an inner container liquid level; gas supply line to supply breathing gas to the inverted container space; and inhalation line having an inlet in the inverted container space to provide breathing gas to patient. The inverted container moves upward from a first elevation when the inverted container space reaches a hydrostatic delivery pressure and volume of the inverted container space increases. The inverted container stops moving upward and the gas supply line stops supplying when the inverted container reaches a second elevation above the first. Based on a breath demand signal or preset timing, the inhalation line opens to permit flow of breathing gas to the patient at the hydrostatic delivery pressure, lowering the inverted container due to lost buoyancy resulting in sinkage.

Abstract: An anesthetic vaporizer system includes a reservoir containing anesthetic agent, an agent level sensor measuring an agent level of the anesthetic agent in the reservoir, a display, and a controller. The controller is configured to receive agent level measurements from the agent level sensor over a time period, and determine the anesthetic agent is being added to the reservoir from an agent source based on the agent level measurements over the time period. A filling status is determined based on the agent level measurements and a filling status indicator is displayed based on the determined filling status.

Abstract: Systems and methods are provided that provide respiration entrainment cues to a user to encourage relaxation or a sleep state. The entrainment cues may be audible, visible, or tactile (or any combination). The entrainment cues include a rhythmic component associated with a target respiration rate and may include sub-components associated with a target breath architecture, such as an inhale-exhale cycle. The systems and methods detect the user's respiration to determine whether the user's respiration matches the entrainment cues or whether the user has fallen asleep.

Abstract: A light health care system including a physiological sensing device, a processor, and a light source device is provided. The physiological sensing device is adapted to acquire physiological data of a user. The processor is coupled to the physiological sensing device, and the processor acquires at least one light parameter corresponding to the physiological data according to the physiological data. The light source device is coupled to the processor, and the light source device outputs a light beam according to the at least one light parameter, wherein a green light beam or a blue light beam in the light beam accounts for more than 40% of the light beam. A light health care method is also provided.

Abstract: The inventive method for making a medical device includes providing a micro plastic tube; molding a hub onto the tube; trimming the tube to a predetermined length; molding a tip onto the tube, and creating a tip that contains a micro orifice at a predetermined angle.

Abstract: A catheter has a jacket (10, 11, 5) defining a lumen and a helical support (6). The catheter has a proximal portion (1) and a distal portion (3), the distal portion having for at least some of its length a corrugated outer surface. A transition portion has a flexural stiffness which is less than that of the distal portion and more than that of the proximal portion. The transition portion provides an optimum transition in flexural stiffness by way of features of the jacket including geometry of jacket corrugations (15), or overlapping tubular layers (1073, 1074). The distal end of the distal portion may have an extension of liner material folded over (1072, 1082) to provide a particularly soft tip. In other examples the liner is terminated (763) before the distal tip. The catheter is particularly suited to an aspiration device (1350) with a flow restrictor (1353) and the distal portion distal of the flow restrictor.

Abstract: An imaging marker for use with a catheter, the imaging marker comprising a plurality of segments including at least two stiff segments and at least one flexible segment, wherein for each pair of stiff segments, one of the flexible segments is located therebetween such that the flexible segment is operable to function as a hinge when the imaging marker is bent. In typical embodiments, the stiff segments are visible under a medical imaging system. In some embodiments, the stiff segments are comprised of a radiopaque material which is visible under an X-ray (fluoroscopy) imaging system.

Abstract: Vascular access devices and methods of their use are provided. In one embodiment, a vascular access device includes a catheter (112) and at least one deployable wire (134). The catheter includes a primary lumen extending from a proximal end to a distal end of the catheter. The at least one deployable wire is secured to the catheter and configured to move relative to the catheter between a delivery configuration and a deployed configuration.

Abstract: A catheter insertion system includes a housing extending along a longitudinal axis. A needle extends distally from a distal end of the housing. The needle has a longitudinal passage coaxially aligned with the housing. A catheter has a length and is sized and shaped to be advanced from a retracted position within the longitudinal passage of the needle to an extended position with at least a portion of the catheter length extending beyond a distal tip of the needle. The needle is typically configured to be retracted back into the housing after the catheter has been advanced, thus providing an integrated catheter and catheter insertion apparatus. After needle retraction, the housing may be taped to the patient's skin while the needle remains protected within the housing. A luer on the catheter may then be connected to a fluid or other source in an otherwise conventional manner.

Abstract: An pressure attenuation device for use in a body can include a balloon comprising an outer wall and defining an interior chamber therein. The balloon can be configured to elastically deform up to at least to an internal pressure of 90 cm H2O. A high vapor pressure media having a vapor pressure of between 155 cm-185 cm H2O at 37 degrees Celsius can be positioned within the interior chamber. The balloon can have a minimum wall thickness of between 0.001 inches-0.00175 inches.

Abstract: A balloon catheter is disclosed for endovascular procedures. In one embodiment, among others, the balloon catheter includes an elongated catheter body. At a distal end, the catheter body also includes an angled tip and a balloon adjacent to the angled tip. The balloon is inflatable to form an oblong shape.

Abstract: A device and associated method for adjusting the opening pressure of an implantable valve. The valve has a rotor of rotation axis, whose angular position determines the opening pressure. The rotor has a rotor micro-magnet movable between positions of locking and unlocking, in which positions the micro-magnet respectively prohibits and permits the rotation of the rotor. The method includes: arranging a locator to align an axis of a locator receptacle with the rotation axis and to orient the locator in an angular position; determining the angular position of the rotor about its rotation axis with respect to the locator; inserting an actuator into the locator receptacle as far as a first insertion depth; partially withdrawing the actuator from the locator receptacle as far as a second insertion depth less than the first insertion depth; rotating the actuator starting from the second insertion depth; separating the actuator from the valve.

Abstract: Provided are a microneedle array capable of improving the visibility of an appearance inspection, and a manufacturing method of the same. A microneedle array is a microneedle array including: a sheet portion having a first surface and a second surface which oppose each other; and a plurality of needle portions arranged on the first surface of the sheet portion, in which the second surface of the sheet portion is configured by a rough surface having peak portions and valley portions, and an average transmittance of the sheet portion in a wavelength range of 300 nm to 740 nm is 75% or less.

Abstract: A microsensor and method of manufacture for a microsensor, comprising an array of filaments, wherein each filament of the array of filaments comprises a substrate and a conductive layer coupled to the substrate and configured to facilitate analyte detection. Each filament of the array of filaments can further comprise an insulating layer configured to isolate regions defined by the conductive layer for analyte detection, a sensing layer coupled to the conductive layer, configured to enable transduction of an ionic concentration to an electronic voltage, and a selective coating coupled to the sensing layer, configured to facilitate detection of specific target analytes/ions. The microsensor facilitates detection of at least one analyte present in a body fluid of a user interfacing with the microsensor.

Abstract: A handle for an applicator of coloured liquid to skin comprises a removable needle module and a needle actuator. The needle module comprises a needle. The handle comprises a handle body having top and bottom portions. The top portion is engagable with the needle actuator and has a top opening for receiving a drive shaft of the needle actuator. The bottom portion is removably engagable with the needle module and has a bottom opening for receiving a needle shaft of the needle. A reciprocally movable interface sealingly engages an internal surface of the handle body. The interface separates the bottom opening from the top opening so as to prevent fluid communication from the bottom opening to the top opening, and is configured to abut the drive shaft and the needle shaft during use to allow the drive shaft to indirectly drive the needle shaft.

Abstract: Antibiotics are administered in a surgical site subcutaneously via a small or stab incision in the surgical field. Transcutaneous ultrasonic vibrations are applied across the surgical field, which is then opened in the usual manner, to thereby provide a surgical field which contains a vastly higher and more effective level of antibiotic. At the same time the underlying tissue is hydrated.

Abstract: A device for reducing agent penetration at an insertion site is provided that has a porous inner sleeve fluidly connected to a conduit. A vacuum or hydrodynamic source is fluidly connected to the conduit. The device is stabilized by fibroblast in-growth and inhibits bacterial colonization. A device is also provided that has a conduit having a bore and an outer conduit surface. The outer conduit surface is optionally nanotextured to promote fibroblast adhesion and limit bacterial residency. A sleeve is provided in fluid communication with the bore of the conduit, and is formed from materials characterized by a pore matrix through which vacuum or hydrodynamic draw is achieved in a process to promote stabilization and reducing bacterial colonization by draw fluid from an area around the surrounding the site of the device. The sleeve optionally has a distal nanotextured surface.

Abstract: A cannula assembly is provided, the cannula assembly comprising a cannula, in particular a graft, for forming a flow channel for bodily fluids, in particular for blood, and a protective element for the cannula, wherein the protective element defines a channel for the cannula, wherein the cannula runs through the channel of the protective element at least in sections, wherein the protective element comprises a plurality of segments, wherein the segments are arranged next to one another in a sequence and wherein each segment defines a sub-section of the channel of the protective element. A blood pump assembly and a method for using the cannula assembly and the blood pump assembly are also provided.

Abstract: A system for supplying power transcutaneously to an implantable device implanted within a subject is provided. The system includes an external connector including one of a microneedle array and a microwire holder. The system further includes a power cable electrically coupled to the external connector and configured to supply power to the one of the microneedle array and the microwire holder, and an internal connector configured to be implanted within the subject and electrically coupled to the implantable device, the internal connector including the other of the microneedle array and the microwire holder. The microneedle array includes a plurality of electrically conductive microneedles, the microwire holder includes a plurality of electrical contacts, and the microwire holder is configured to engage the microneedle array such that the plurality of electrically conductive microneedles extend through the skin of the subject and electrically couple to the plurality of electrical contacts.

Abstract: An object of the present invention is to provide a gel sheet comprising an intermediate base, having no variation in adhesiveness. A gel sheet 1 comprising a gel material 10 and an intermediate base 20 embedded in the gel material 10, wherein when T represents the thickness of the gel sheet 1, and S represents the amplitude of the intermediate base 20, a relation represented by the following expression (1) is satisfied: S/T?0.

Abstract: Apparatus (20) is provided, including a bifurcation stent (50) comprising one or more electrodes (32), the stent (50) configured to be placed in a primary passage (52) and a secondary passage (54) of a blood vessel (30), and a control unit (34), configured to drive the electrodes (32) to apply a signal to a wall (36) of the blood vessel (30), and to configure the signal to increase nitric oxide (NO) secretion by the wall (36). Other embodiments are also described.

Abstract: The present invention refers to a photosensitive pixel structure (10) comprising a substrate (15) with a front surface and a back surface, wherein at least one photosensitive diode (12, 12?) is provided on one of the surfaces of the substrate (15). A first material layer (30) is provided at least partially on the back surface of the substrate (15), wherein the material layer (30) comprises a reflective layer, in order to increase a reflectivity at the back surface of the substrate. Further, the present invention refers to an array (1) and an implant comprising such a photosensitive pixel structure (10), as well as to a method to produce the pixel structure (10).

Abstract: A system for providing non-invasive neuromodulation to a patient includes a mouthpiece and a controller. The mouthpiece includes an elongated housing, a printed circuit board, and control circuitry mounted within the elongated housing. The controller includes an elongated u-shaped element, an electronic receptacle, and a microcontroller. A method for providing non-invasive neurorehabilitation of a patient including connecting a mouthpiece to a controller, transmitting a numeric sequence to the mouthpiece, generating a first hash code, transmitting the first hash code to the controller, generating a second hash code, comparing the second hash code with the first hash code, enabling electrical communication between the mouthpiece and the controller only if the first hash code matches the second hash code, contacting the mouthpiece with the patient's intraoral cavity, and delivering neurostimulation to the patient's intraoral cavity.

Abstract: A medical delivery device for delivering a medical device includes a navigable elongated member, a deployment bay, and a compression mechanism. The deployment bay may be configured to house the medical device as the medical device is navigated to the target site. The deployment bay may be at a distal end of the delivery device and may include a distal opening through which the medical device may be deployed. The compression mechanism is configured to longitudinally compress in response to a predetermined force such that the elongated member and deployment bay are relatively closer together along a longitudinal axis of the delivery device.

Abstract: The capsule includes a tubular body and a front-end unit including an anchoring member for the anchoring of the capsule to a wall of a patient's organ. The front-end unit is mobile in relative axial rotation with respect to the tubular body, and a disengageable coupling member is adapted to allow this relative rotation when the tubular body receives an external rotational stress, the anchoring member then exerting a reaction torque higher than a predetermined threshold torque, and to prevent the relative rotation in the absence of external rotational stress applied to the tubular body. The coupling member may in particular include, between the front-end unit and the tubular body, a friction interface, with an elastically deformable element applying an axial compression between a bearing face of the tubular body and a support ring integral with the anchoring member.

Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical noninvasive stimulation of a vagus nerve. The system comprises a stimulator that is applied to the surface of the patient's neck. The device housing transmits data to a patient interface device such as a mobile phone or computer relating to the status of a stimulation session. The interface device in turn may communicate with a database contained within other computers, via a network or the internet. The system is designed to address problems that arise particularly during self-treatment, when a medical professional is not present.

Abstract: A patient treatment unit for delivering non-invasive pulsed energy to living tissue with a probe stimulus generator circuit configured to output, as a treatment signal, a sequence of DC electrical pulses at a controlled pulse frequency of about 20 kHz and having a pulse voltage defined by a variable supply voltage of the probe stimulus generator circuit. The unit includes primary and secondary probes for contacting a body, an intensity adjustment circuit configured to control the variable supply voltage, and an electronic timer display configured to display an elapsed time in decimal numbers in minute and second format. An electrical current of the pulses is in a range of 0.1-2 mA while the probes are contacting the body. An operating output voltage across the probes while conducting the treatment signal does not exceed a maximum operating output voltage of 165 VDC while the probes are contacting the body.

Abstract: A patient treatment unit for delivering non-invasive pulsed energy to living tissue with a probe stimulus generator circuit configured to output, as a treatment signal, a sequence of DC electrical pulses at a controlled pulse frequency of about 20 kHz and having a pulse voltage defined by a variable supply voltage of the probe stimulus generator circuit. The unit includes primary and secondary probes for contacting a body, an intensity adjustment circuit configured to control the variable supply voltage, and an electronic timer display configured to display an elapsed time in decimal numbers in minute and second format. An electrical current of the pulses is in a range of 0.1-2 mA while the probes are contacting the body. An operating output voltage across the probes while conducting the treatment signal does not exceed a maximum operating output voltage of 165 VDC while the probes are contacting the body.

Abstract: Methods for automatically programming a signal generator in a patient therapy system and associated systems are disclosed. A representative method comprises retrieving data including therapy program parameters, level of efficacy, and medication use corresponding to a plurality of time periods; identifying from the data a target time period having a corresponding level of efficacy; determining from the data if medication was used during the target time period; determining from the data if medication was used during a prior time period immediately before the target time period; calculating a lead position confidence factor; and programming the signal generator to repeat therapy with the therapy program parameters corresponding to the target time period if the confidence factor is greater than a threshold value and medication was used during the prior time period and not during the target time period.

Abstract: A system for treating obstructive sleep apnea (OSA) is described. The system may include a locking device having a size and shape selected to couple to skin along a jaw of a patient. The locking device may be configured to receive at least one of a needle or an introducer for insertion into a tongue of the patient for lead placement of a lead for OSA treatment, and lock at least a portion of the at least one of the needle or introducer in place to reduce movement of the needle or introducer within the tongue.

Abstract: A method for optimization of the stimulation pattern of a set of implanted electrodes in excitable tissue of a patient is disclosed, wherein it comprises the steps of: (a) choosing a first group of a certain number of from said set of implanted electrodes, (b) stimulating the excitable tissue electrically by said first group of electrodes, (c) registering information provided by the patient, (d) assigning each electrode of said first group of electrodes a value related to said information, wherein these steps are repeated for one or more further groups of said certain number of electrodes chosen from said set of implanted electrodes, wherein each electrode may be included in one or several groups, wherein the total assigned value for each electrode is calculated, and wherein electrodes having a total assigned value exceeding a predetermined value or a predetermined number of the electrodes having the highest total assigned value are chosen to be included in said stimulation pattern, as well as a method for tr

Abstract: A system includes a memory and a processor. The memory is configured to store a definition of a cardiac pacing protocol. The processor is configured to (a) receive the stored definition of the cardiac pacing protocol, (b) in accordance with the pacing protocol, to automatically pace from an intracardiac location and to acquire respective sensed ECG signals, (c) based on one or more prespecified criteria for validity of the sensed ECG data, automatically accept or reject the sensed ECG signals, (d) based on one or more prespecified criteria for identification of an arrhythmia, identify the intracardiac location as an arrhythmogenic focus or pathway, (e) overlay the identified intracardiac location an electrophysiological (EP) map, and (f) subsequently identify or reject a new intracardiac location as an arrhythmogenic focus or pathway and overlay the new location on the EP map when pacing again from the new intracardiac location.

Abstract: A nerve activity blocking system (100) includes a blocking electrode (102) configured to generate a blocking electrical signal that blocks, at least in part, an action potential propagating through a nerve system of a body. using a low frequency alternating current. The blocking electrical signal prevents propagation of the action potential by overriding another electrical signal controlling an organ of the body.

Abstract: During charging of implantable devices via inductive coupling, heat may be produced within the implantable device, so control of the charging may be desirable to reduce or avoid the risk of undesirable tissue heating. Exchanging parameters relevant for charging may prevent undesirable heating, but typically increase the complexity of the devices used. An implantable device is provided, for wirelessly receiving energy pulses, monitoring the energy storage, and transmitting a first sufficient energy signal if the energy storage exceeds a first maximum value. An associated energy transmission device is provided, for wirelessly transmitting a plurality of successive energy pulses transmitted at a first power level, pausing energy transmission immediately after the first sufficient energy signal is received, and subsequently resuming energy pulse transmission at the first power level if no further sufficient energy signal is received.

Abstract: Stimulation treatments for various medical disorders, such as neurological disorders, comprise novel systems, strategies, and methods for providing TMS, electrical, magnetic, optical and other stimulation modalities. Some stimulation methods comprise varying the stimulation parameters to improve the therapeutic efficacy of stimulation and decrease risk of habituation and side-effects such as interference with normal brain, sensory, motor, and cognitive processes. The creation, and subsequent variation, of stimulation parameters can use sensed data in order to match, adjust, or avoid matching characteristics of the stimulation therapy relative to certain endogenous brain activities. Novel methods are described for choosing, creating and subsequently stimulating with partial signals which summate to produce therapeutic vector fields having unique temporal patterns and low- or high-frequency spectral content. Improvements for the treatment of pain are disclosed.

Abstract: An electric stimulator for heart (as in heart pacemakers), brain (as in DBS), organs and general cells, with electrodes in the space surrounding the main stimulating electrodes. These surrounding electrodes are more effective at creating the best electric field to guide the stimulating electric charges necessary for the purpose of the device. The surrounding electrodes are supported on a second supporting device, while the main electrodes are in a first supporting device we call picafina.

Abstract: According to some embodiments, a device operates by comparative morphological analysis of depolarization signals collected in spontaneous rhythm on separate respective channels, with two temporal components combined into a single 2D parametric VGM vectogram characteristic. Similarity quantification methods evaluate a variation over time of a descriptor parameter of a current VGM compared to a stored previous reference VGM. This variation is compared with predetermined thresholds to diagnose an occurrence of remodeling or reverse remodeling in a patient, and/or to detect a lead failure or an occurrence of ischemia. The descriptor parameter is a function of a velocity vector of the VGM, a comparison relating to a correlation coefficient between respective magnitudes of a current VGM velocity vector and of a reference VGM velocity vector, and an average angle between these respective velocity vectors.

Abstract: This document discusses, among other things, systems and methods to generate a first pacing waveform during a first pacing period and a second pacing waveform during a second pacing period, and alternate the first and second pacing periods to provide pacing-based hypertension therapy to a heart of a patient to reduce patient blood pressure, wherein the first pacing waveform has a first atrioventricular (AV) delay and the second pacing waveform has a second AV delay longer than the first AV delay. Physiologic information can be received from the patient, and one of the first or second pacing period for delivery to the patient can be determined using the received physiologic information.

Abstract: Generally discussed herein are systems, devices, and methods for providing a therapy (e.g., stimulation) and/or data signal using an implantable device. Systems, devices and methods for interacting with (e.g., communicating with, receiving power from) an external device are also provided.

Abstract: Programming a stimulator device to deliver a stimulation therapy at high-density parameter settings using a cathode-minimized electrode configuration determined to induce paresthesia over a patient pain pattern at low-density parameter settings.

Abstract: Catheter and implantable leadless pacing devices, systems, and methods utilizing catheters and implantable leadless pacing devices are disclosed. An example catheter system may include a holding structure extending distally from a tubular member. An implantable device, such a leadless pacing device, may be located within a cavity of the holding structure and an electrical barrier may be located within the holding structure at a location between a proximal electrode and a distal electrode of the implantable device. The electrical barrier may inhibit electrical signals of the implantable device from traveling within the holding structure between the proximal electrode and the distal electrode of the implantable device. The holding structure may include one or more electrical ports adjacent the proximal end of the holding structure and adjacent or proximal of the proximal electrode of the implantable device.

Abstract: A hermetically sealed filtered feedthrough assembly attachable to an AIMD includes an insulator hermetically sealing a ferrule opening of an electrically conductive ferrule with a gold braze. A co-fired and electrically conductive sintered paste is disposed within and hermetically seals at least one via hole extending in the insulator. At least one capacitor is disposed on the device side. An active electrical connection electrically connects a capacitor active metallization and the sintered paste. A ground electrical connection electrically connects the gold braze to a capacitor ground metallization, wherein at least a portion of the ground electrical connection physically contacts the gold braze. The dielectric of the capacitor may be less than 1000 k. The ferrule may include an integrally formed peninsula portion extending into the ferrule opening spatially aligned with a ground passageway and metallization of an internally grounded feedthrough capacitor.

Abstract: In one embodiment, a wearable cardioverter defibrillator (WCD) is described. The WCD includes a support structure that may be worn by a patient. A processor is coupled to the support structure. The wearable cardioverter defibrillator also includes a discharge circuit configured to discharge a stored electrical charge through a body of the patient, the discharge circuit in communication with the processor. The processor may be configured to detect an event occurring at the WCD and determine a severity of the event occurring at the WCD. The processor may activate a multi-sensory alarm based at least in part on the determined event severity.

Abstract: An in-vehicle automated external defibrillator system and a method of controlling the same, for detecting a state of a driver and applying an electric shock to his or her heart in the event of emergency, are disclosed. The method of controlling the in-vehicle automated external defibrillator system includes determining, by a driver state recognition device, a state of a driver through a state determination device, upon determining that the driver is in a cardiac arrest state, determining, by a heart impulse position controller, two current pads among a plurality of current pads disposed in a seat belt, determining, by a heart impulse intensity controller, current to be applied through the two determined current pads, and applying, by the heart impulse intensity controller, the determined current through the two determined current pads.

Abstract: A remote alarm for use with a wearable medical device. The remote alarm is configured to receive alarms, voice messages and prompts issued by the wearable medical device and to repeat those alarms, voice messages and prompts in a manner that can more easily be perceived by a patient wearing the wearable medical device or a bystander. The remote alarm can be configured to receive a communication from the wearable medical device, and in response, to identify one or more messages to be provided to the patient or a bystander. The messages may be provided audibly, visually, tactilely or combinations thereof. The remote alarm may further be configured to take certain actions depending upon the content of the communication, such as sending a telephone message to alert emergency personnel to the identity, location and medical condition of the patient, or sending an email.

Abstract: A method for evaluating a treatment for a brain condition, including: extracting one or more microstate parameter values from at least one EEG signal that was measured after the treatment; and evaluating at least one parameter of the treatment based on the one or more microstate parameter values.

Abstract: An optical output device for skin care, according to an embodiment of the present disclosure, comprises: a substrate disposed such that at least one light source is oriented toward a user's skin; a front cover covering one surface of the substrate; a rear cover covering the other surface of the substrate; a wearing device coupled to the rear cover so as to make contact with a part of the user's body such that the optical output device for skin care is worn by the user; and a wearing detection sensor for detecting whether the user is wearing the device.

Abstract: The present disclosure provides methods for generating tunable white light with controllable circadian energy performance. The methods use a plurality of LED strings to generate light with color points that fall within blue, yellow/green, red, and cyan color ranges, with each LED string being driven with a separately controllable drive current in order to tune the generated light output. Different light emitting modes can be selected that utilize different combinations of the plurality of LED strings in order to tune the generated white light.

Abstract: Provided is a charged particle irradiation apparatus that performs scanning with a charged particle beam and irradiates an irradiation target spot by spot. An embodiment of the present invention provides a charged particle irradiation apparatus (10) including: a first dose monitor (54) mounted in an irradiation nozzle (50); an irradiation pattern converting device (70) that generates irradiation control data used for controlling the charged particle irradiation apparatus (10) from treatment plan data including information on a dose rate and a dose of a charged particle beam for each spot; and a dose correction factor storage unit (72) that stores data of a dose correction factor with respect to a dose rate of a charged particle beam. The irradiation pattern converting device (70) is configured to select one spot in the treatment plan data, for instance.

Abstract: A neutron capture therapy system, including a beam shaping assembly, and a vacuum tube and at least one cooling device. The beam shaping assembly includes a beam inlet, an accommodating cavity accommodating the vacuum tube, a moderator adjacent to an end portion of the accommodation cavity, a reflector surrounding the moderator, and a radiation shield and a beam outlet arranged in the beam shaping assembly. An end portion of the vacuum tube is provided with a target. The cooling device undergoes a nuclear reaction with a charged particle beam incident from the beam inlet to produce neutrons. The moderator decelerates the neutrons produced by the target to an epithermal neutron energy region. The reflector leads deviating neutrons back to the moderator. At least one accommodating pipeline accommodating the cooling device is arranged in the beam shaping assembly. A filler is filled between the cooling device and the accommodating pipeline.