Abstract: The present invention provides an anti-LAG-3 antibody capable of repeated administration even to animals other than rat. An anti-LAG-3 antibody comprising (a) a light chain comprising a light chain variable region containing CDR1 having the amino acid sequence of QSLLDSDGNTY (SEQ ID NO: 16), CDR2 having the amino acid sequence of SVS and CDR3 having the amino acid sequence of MQATHVPFT (SEQ ID NO: 17) and the light chain constant region of an antibody of an animal other than rat; and (b) a heavy chain comprising a heavy chain variable region containing CDR1 having the amino acid sequence of GFDFDTYP (SEQ ID NO: 18), CDR2 having the amino acid sequence of ITIKTHNYAT (SEQ ID NO: 19) and CDR3 having the amino acid sequence of NREDFDY (SEQ ID NO: 20) and the heavy chain constant region of an antibody of an animal other than rat. A pharmaceutical composition comprising the above anti-LAG-3 antibody as an active ingredient. A method for preparing the above anti-LAG-3 antibody is also provided.

Abstract: This invention relates to the combination of cabozantinib and atezolizumab to treat locally advanced or metastatic solid tumors, particularly advanced urothelial cancer or renal cell carcinoma.

Abstract: Disclosed are Fc-containing proteins comprising a binding region and a variant Fc region that can elicit one or more immune effector function and/or bind to an Fc receptor more effectively than a similar Fc-containing protein comprising a wild type Fc region. Also disclosed are nucleic acids encoding such Fc-containing proteins, methods for making such proteins, and methods of treatment utilizing such proteins.

Abstract: The present invention provides a pharmaceutical composition for inhibiting the metastasis of cancer, comprising, as an active ingredient, an antibody that specifically binds to an epidermal growth factor receptor, and a method for inhibiting the metastasis of cancer using the composition. The composition or the method is effective in inhibiting the invasion of various gastric cancer cell lines induced by EGFR ligands. Therefore, the pharmaceutical composition can be usefully used for inhibiting the metastasis of cancer.

Abstract: The present disclosure relates to antibodies that specifically bind a novel epitope on the AxI protein. Also disclosed are methods for the production and use of the anti-Axl antibodies.

Abstract: The present invention provides antibodies that bind Glucocorticoid Induced Tumor necrosis factor Receptor family related protein (GITR) and methods of using same. The anti-GITR antibodies can be used therapeutically alone or in combination with other therapeutics to treat cancer and other diseases.

Abstract: The invention generally relates to antibodies that bind to human folate receptor and diagnostic assays for folate receptor 1-based therapies. Methods of using the antibodies to monitor therapy are further provided.

Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. The ligand that binds a protein associated with a TCR complex is UCHT1 with a Y177 mutation. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.

Abstract: The present invention relates to therapeutic antibodies for the treatment of cancer, and more specifically, for the treatment of prostate, bladder, and/or pancreatic cancer. An embodiment of the present invention is an anti-glypican-1 (GPC 1) antibody, which may be conjugated to at least one cytotoxic agent that is toxic to a prostate, bladder, and/or pancreatic cancer cell.

Abstract: The present application relates to optimized IgG immunoglobulin variants, engineering methods for their generation, and their application, particularly for therapeutic purposes.

Abstract: Disclosed is a dispersion of metal-containing oxidized cellulose nanofibers with superior dispersibility, which is applicable to various uses. The disclosed metal-containing oxidized cellulose nanofiber dispersion comprises a dispersion medium, and metal-containing oxidized cellulose nanofibers containing a metal other than sodium in salt form, wherein the metal-containing oxidized cellulose nanofibers have a number-average fiber diameter of 100 nm or less and an average degree of polymerization of 100 to 2,000.

Abstract: The object of the present invention relates to the new and surprising use of sulfated hyaluronic acid (HAS) as regulator agent of the cytokine activity (pro- and anti-inflammatory) and consequently the use of HAS for the preparation of a new medicine for topic use in the prevention and treatment of pathologies associated with the activation and/or deficiency of cytokines of a pro- and anti-inflammatory nature. The Applicant has in fact discovered the exclusive capacity of HAS in modulating the activity of these particular proteins, it has studied the action mechanism and demonstrated the substantial difference between the different sulfated types known in the state of the art, but above all it has demonstrated an unexpectedly high activity of HAS vs different types and strains of Herpes virus, Cytomegalovirus and the virus of vesicular stomatitis. Finally, a further object of the present invention is the use of HAS as a skin absorption promoter of drugs of an anti-inflammatory nature.

Abstract: A process is described for the purification of HA, and pharmaceutical, cosmetic and nutritional compositions containing HA thus purified.

Abstract: A process for the continuous synthesis of a modified diene elastomer comprising at least one silicon atom directly connected to the elastomer chain is provided. The process comprises polymerization by n reactors r1 to rn, considered to be continuous stirred-tank reactors equipped with an internal stirring system and arranged in series, n varying from 2 to 15. The reactor r1 is fed by an input solution comprising a solvent, one or more monomer(s), an anionic polymerization initiator chosen from lithium amides and a polar agent. The temperature of each reactor varies from 20° C. to 150° C. and is greater than or equal to the temperature of the reactor which immediately precedes it. The living diene elastomer obtained exhibits a polydispersity index varying from 1.1 to 1.7. The process further comprises modification of the living diene elastomer obtained in the preceding stage by a functionalization, coupling or star-branching agent.

Abstract: The present invention provides a 1,3,7-octatriene polymer having a narrow molecular weight distribution and a hydride thereof. Specifically, the 1,3,7-octatriene polymer is a polymer containing a structural unit derived from 1,3,7-octatriene, wherein the polymer has not only a molecular weight distribution (Mw/Mn) of 2.05 or less but also a weight average molecular weight (Mw) of 1,000 to 1,000,000.

Abstract: The present disclosure relates to poly(alpha-olefin)s and methods for making poly(alpha-olefin)s. A poly(alpha-olefin) may include about 95 wt % or greater C10-C18 alpha-olefin content and have a weight average molecular weight of from about 1,000,000 g/mol to about 10,000,000 g/mol. A method for forming a poly(alpha-olefin) may include introducing one or more C10-C18 alpha-olefins to a catalyst system comprising a catalyst compound and an activator. The method may include obtaining poly(alpha-olefin)s comprising about 95 wt % or greater C10-C18 alpha-olefin content and having a weight average molecular weight of from about 1,000,000 g/mol to about 10,000,000 g/mol.

Abstract: The present invention relates to an ethylene copolymer obtained by radical polymerisation through a high-pressure process comprising (i) ?78.0 and ?99.99 mole % of recurring units derived from ethylene; (it) ?0.01 and ?22.0 mole % of recurring units derived from comonomer A according to Formula (I), wherein R1 is composed of a saturated aliphatic moiety comprising 5-40 carbon atoms or R1 is composed of a saturated aliphatic moiety and consists of hydrogen atoms and 5-40 carbon atoms; R2 is selected from —H or —CH3; R3 is selected from —O—, —(CO)—(NH)— or —(CO)—O—; n=0 or 1 The ethylene copolymers have a reduced peak melting temperature and reduced enthalpy of fusion, indicating that these ethylene copolymers have a reduced degree of crystallinity and improved clarity, combined with a desired melt mass-flow rate.

Abstract: The present disclosure relates to dual catalyst systems and processes for use thereof. The present disclosure further provides a catalyst system that is a combination of at least two hafnium metallocene catalyst compounds. The catalyst systems may be used for olefin polymerization processes. The present disclosure further provides for polymers, which can be formed by processes and catalyst systems of the present disclosure.

Abstract: Disclosed is a resin comprising a structural unit derived from a compound represented by formula (I) and a structural unit having an acid-labile group: wherein R1 represents a hydrocarbon group which may have a substituent, R2 each independently represent an alkyl group which may have a halogen atom, a hydrogen atom or a halogen atom, Ar represents an aromatic hydrocarbon group which may have a substituent, L1 represents a group represented by formula (L1-1), etc., L11, L13, L15 and L17 each independently represent an alkanediyl group, L12, L14, L16 and L18 each independently represent —O—, —CO—, —CO—O—, etc., * and ** are bonds, and ** represents a bond to an iodine atom.

Abstract: An object of the present invention is to provide a macromolecular material that exhibits excellent elongation. The first macromolecular material of the present invention contains the first polymer containing the first structural unit and the second polymer containing the second structural unit. The first structural unit has a guest group in its side chain, and the second structural unit has a host group in its side chain. At least one of the first and the second polymers contains at least one fluorine group. The second macromolecular material of the present invention contains the first structural unit having a guest group in its side chain, the second structural unit having a host group in its side chain, and the third structural unit other than the first and second structural units. At least one of the first, the second, and the third structural units contains at least one fluorine group.

Abstract: A method for producing a carboxyl group-containing nitrile rubber including the steps of: polymerizing a monomer mixture including an ?,?-ethylenically unsaturated nitrile monomer and a carboxyl group-containing monomer in a solvent; terminating a polymerization reaction by adding a nitrous acid salt and a water-insoluble hydroquinone as polymerization terminators to the polymerization system, thereby obtaining a dispersion of the carboxyl group-containing nitrile rubber having a pH of 7 or below; and coagulating the dispersion of the carboxyl group-containing nitrile rubber, thereby obtaining the carboxyl group-containing nitrile rubber in the solid state, wherein the amount of the nitrous acid salt to be used is 0.15 parts by weight or less relative to 100 parts by weight of the monomer mixture used in the polymerization reaction.

Abstract: The present invention provides a water-soluble silicone macromer. The water-soluble silicone macromer has a general formula: E?(M1)x?(M2)y, wherein M1 is a repeating unit which is derived from a silicone containing monomer, M2 is a repeating unit which is derived from a first hydrophilic monomer, and E is an ethylenically unsaturated group. The amount of M1 is in a range of 30-60 wt % based on the total weight of the water-soluble silicone macromer, and the amount of M2 is in a range of 40-70 wt % based on the total weight of the water-soluble silicone macromer. A silicone hydrogel composition containing the water-soluble silicone macromer and a silicone hydrogel lens made of the silicone hydrogel composition are also provided herein.

Abstract: The present invention relates to a polymer-graphene composite, in which a polymer has been introduced onto the surface of graphene while maintaining the structural features and mechanical properties of the graphene, thereby realizing an excellent dispersibility in an organic solvent, a method for preparing the same, and a polymer-graphene composite composition using the same.

Abstract: Polyurethane foams and methods of manufacturing are described herein. The foam can include (a) a polyurethane formed by the reaction of (i) one or more isocyanates selected from the group consisting of diisocyanates, polyisocyanates, and mixtures thereof, and (ii) one or more polyols; and (b) a filler. The amount of filler in the foam can be from 50 to 90% by weight, based on the total weight of the foam. The filler can include a plurality of fibers and/or a particulate filler. The polyurethane foams described herein are made without adding a surfactant to the reaction mixture. The density of the polyurethane foam can be at least 5 lb/ft3.

Abstract: Heat-curing epoxy resin compositions are characterized by high impact strength, good storage stability, and a low curing temperature. The epoxy resin compositions are suitable for use as a construction shell adhesive and for producing structural foams. They can already be cured in so-called bottom-baking conditions. Furthermore, it has been found that the use of an accelerator of the formula (Ia) or (Ib) results in an increase of the impact strength of heat-curing epoxy resin compositions.

Abstract: The present invention provides an epoxy resin including a reaction product of 1,2,4-trihydroxybenzene and an epihalohydrin, the epoxy resin containing a cyclic compound that has a cyclic structure containing, as constitutional atoms, oxygen atoms at 1-position and 2-position derived from 1,2,4-trihydroxybenzene, the cyclic compound being contained in an amount of 0.003 to 0.070 mol based on 100 g of the epoxy resin. The epoxy resin is liquid and is excellent in pyrolysis resistance.

Abstract: The present disclosure provides a curable composition that includes an epoxy resin and a curing component comprising a blend of at least two amines. The curable composition may be combined with reinforced fibers and cured to form a composite article which can be used in various applications, such as in wind turbine blades.

Abstract: A composition includes a photolatent amine, camphorquinone, and a coumarin sensitizer. The coumarin sensitizer is triplet photosensitizer and has an absorbance with a wavelength of maximum absorbance in a range from 390 nanometers to 510 nanometers. Compositions that further include a polymerizable material are also disclosed. Polymer networks preparable from such compositions and methods for making the polymer networks are also disclosed.

Abstract: Aromatic polyester particles which are formed from an aromatic polyester having a flow starting temperature of 400° C. or higher and have a circularity of a projected image of 0.80 or more and 1.00 or less.

Abstract: The present invention provides a polycarbonate copolymer having low specific gravity and high surface hardness.

Abstract: A method of producing a polyether polyol that includes reacting a low molecular weight initiator with ethylene oxide in the presence of a polymerization catalyst, the low molecular weight initiator having a number average molecular weight of less than 1,000 g/mol and a nominal hydroxyl functionality at least 2, and the polymerization catalyst being a Lewis acid catalyst having the general formula M(R1)1(R2)1(R3)1(R4)0 or 1. Whereas, M is boron, aluminum, indium, bismuth or erbium, R1, R2, and R3 each includes a same fluoroalkyl-substituted phenyl group, and optional R4 includes a functional group or functional polymer group. R1, R2, and R3 are the same fluoroalkyl-substituted phenyl group. The method further includes forming a polyether polyol having a number average molecular weight of greater than the number average molecular weight of the low molecular weight initiator in the presence of the Lewis acid catalyst.

Abstract: Synthesis of polyionenes with built-in degradable linkers through addition polymerization of a novel class of degradable A2-type monomers (d-A2), and their use as antimicrobial agents are disclosed. A library of biodegradable polyionenes and Gemini-surfactants made from d-A2 monomers are also disclosed. These materials have potent and broad spectrum of antimicrobial activity with high selectivity over mammalian cells.

Abstract: A polyimide that is a reaction product of a diamine represented by Chemical Formula 1, a diamine represented by Chemical Formula 2, and a tetracarboxylic dianhydride represented by Chemical Formula 3: wherein, in Chemical Formulae 1 to 3, L1, L2, Ra to Rf, m, R2, R10, R12, R13, n7, and n8 are the same as defined in the specification.

Abstract: Disclosed are oral care compositions of novel phosphono-phosphate and anionic group containing polymer compositions that have targeted uses with divalent cations and surfaces having divalent cations. These compounds can be used to deliver anionic character to surfaces such as calcium hydroxyapatite for use in oral care applications.

Abstract: The present invention pertains among others to a method of preparing a biomass mash from a biomass comprising lignin. The invention also pertains to a biomass mash comprising reduced viscosity.

Abstract: A method of preparing a hydrogel product comprising crosslinked glycosaminoglycan molecules, said method including: i) providing a glycosaminoglycan crosslinked by amide bonds, wherein the crosslinked glycosaminoglycans include ester crosslinks formed as byproducts during the amide crosslinking; and ii) subjecting the crosslinked glycosaminoglycans to alkaline treatment to hydrolyze ester crosslinks formed as byproducts during the amide crosslinking.

Abstract: The present invention provides a method for producing a molded article by pressing a composite material containing a resin composition and carbon fibers, wherein the resin composition contains a polyamide resin, a copper compound and potassium halide, and (1) the copper compound content is 0.1 parts by mass or more relative to 100 parts by mass of the polyamide resin.

Abstract: The present invention relates to plastic composition comprising at least one polyester, biological entities having a polyester-degrading activity and at least an anti-acid filler, wherein the biological entities represent less than 11% by weight, based on the total weight of the plastic composition, and uses thereof for manufacturing biodegradable plastic articles.

Abstract: The present invention relates to a method for preparing superabsorbent polymer. According to the preparation method of the present invention, the surface penetration depth of a surface crosslinking agent can be appropriately controlled, and superabsorbent polymer with excellent properties can be prepared though homogeneous surface crosslinking. Thus, superabsorbent polymer with improved absorption property can be provided without deterioration of absorbency under load.

Abstract: The present invention relates to plastic films with improved laser engraving capability, chemical resistance and mechanical stress, special embodiments of such films in the form of co-extrusion films, layer structures comprising such films, use of such films, as well as security documents, preferably identification documents, containing such films.

Abstract: The present disclosure relates to an interlayer film for laminated glass comprising: (a) polyvinyl butyral (PVB) resin having an average molecular weight (Mw) as measured by Gel Permeation Chromatography (GPC) from about 175,000 to about 210,000 Dalton; and (b) about 30 to about 50 parts per hundred (pph) of a plasticizer. The interlayer film interposed between two glass sheets forms laminated glass having a pummel adhesion value that is greater in an outer area of the laminated glass than in a middle area of the laminated glass after the laminated glass has been maintained at 50° C. and 95% relative humidity (RH) for 28 days. The laminated glass exhibits improved durability and does not delaminate over time, even in the presence of high temperature and humidity conditions.

Abstract: A method for producing an anisotropic conductive sheet that can be used for an inspection of a semiconductor package or a high-frequency component part, in which the pitch of wiring is narrowed and the wiring itself has been subjected to wire thinning, and that can be easily produced. A method for producing an anisotropic conductive sheet, includes a molding step of molding a conductive filler material-containing composition including (A) a conductive filler material dispersed in an organic solvent and (B) a binder resin, into a sheet-like body, and an organic solvent volatilization step of heating one surface of the sheet-like body and thereby volatilizing the organic solvent through the other surface of the sheet-like body.

Abstract: To provide a surface treatment liquid capable of making a base material including polyorganosiloxane on at least a part of a surface thereof hydrophilic stably over a long period of time, and provide a surface treatment method using the surface treatment liquid. In a surface treatment liquid including (A) resin and a (B) solvent, as the (A) resin, resin having a functional group I that is a hydroxyl group and/or a cyano group is used, and a functional group II that is a hydrophilic group other than the functional group I, and a ratio of a structural unit having an anionic group to total structural units of the (A) resin is 5 mol % or less, or resin including a cationic group including an anion moiety and a cation moiety that can be bonded to the (A) resin is used.

Abstract: The presently disclosed subject matter is directed to a method of making a foam, specifically, the development of isocyanate-free foams using at least one unsaturated polyester. The at least one unsaturated polyester is a reaction product of at least one unsaturated cyclic anhydride, dicyclopentadiene, and at least one polyol. The disclosed formulation further comprises at least one reactive diluent and at least one initiator. The disclosed formulations are cured by a free radical mechanism.

Abstract: Core particles produced in situ or introduced as preformed core particles are coated with a layer of carbon. Non-carbon as well as some carbon-based core materials can be utilized. The resulting carbon coated particles can find applications in rubber products, for instance as reinforcement for tire components.

Abstract: A resin composition includes a resin (A), a resin (B), and resin particles (C), and has a continuous phase containing the resin (A) and dispersed phases containing the resin (B), in which when a cross section of the resin composition along an extrusion direction in producing the resin composition is observed, an area circle equivalent diameter d80, which is an area circle equivalent diameter corresponding to 80% from a small diameter side in a number cumulative distribution of area circle equivalent diameters of the dispersed phases, is 600 nm or less.

Abstract: Provided is a resin composition containing: a cellulose acylate (A); a thermoplastic elastomer (B); and a fiber (C).

Abstract: The present invention relates to a modified conjugated diene-based polymer, and more particularly, a modified conjugated diene-based polymer prepared by continuous polymerization and having remarkable processability, narrow molecular weight distribution and excellent physical properties, and a rubber composition including the same.

Abstract: As a nonaqueous electrolyte secondary battery separator having a transverse direction/machine direction crease recovery angle ratio of close to 1, a nonaqueous electrolyte secondary battery separator is provided that includes a polyolefin porous film having a ratio of a 60-degree gloss in an machine direction to a 60-degree gloss in a transverse direction which ratio is not less than 1.00.

Abstract: The present invention relates to a propylene-butene copolymer resin composition used for non-woven fabric, a method of preparing the same, and spunbond non-woven fabric manufactured using the composition, and particularly, by optimizing a content of 1-buttene in a metallocene polypropylene resin composition to 0.5 to 5.0 wt %, while simultaneously optimizing both of a melt index and a residual stress ratio of the resin composition, has a merit of having a reduced modulus together with a high conversion rate to manufacture non-woven fabric which is softer than existing products while maintaining high strength.