Patents Issued in December 14, 2021
  • Patent number: 11198880
    Abstract: To produce a bacterial microcompartment shell, or a designed shell based on naturally occurring bacterial microcompartment shells in a new host organism, a synthetic operon is constructed that contains the desired shell protein genes and translation efficiency is controlled by host specific ribosomal binding sites. Proteins or other molecules can be encapsulated in the microcompartment shells by various methods described herein. The constructs can also be used to express self-assembling sheets comprised of shell proteins.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: December 14, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Cheryl A. Kerfeld, Jonathan K. Lassila, James N. Kinney, Markus Sutter, Steven C. Wilson
  • Patent number: 11198881
    Abstract: The present disclosure concerns recombinant yeast host cell for saccharification of a biomass. The recombinant yeast host cell has a genetic modification for expressing a heterologous polypeptide having glucoamylase activity (Rasamsonia emersonii glucoamylase). In some embodiments, the heterologous polypeptide comprises the signal sequence associated with the alpha-mating 1 factor. The present disclosure also concerns a process for saccharification of a biomass using the recombinant yeast host cell as well as a process for fermenting the saccharified biomass into a fermentation product.
    Type: Grant
    Filed: November 25, 2020
    Date of Patent: December 14, 2021
    Assignees: Lallemand Hungary Liquidity Management LLC, BASF SE
    Inventors: Aaron Argyros, Alexandra Panaitiu, Charles Rice, Kenneth Barrett
  • Patent number: 11198882
    Abstract: As disclosed herein, optimal native genomic loci from maize plants have been identified that represent best sites for targeted insertion of exogenous sequences.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: December 14, 2021
    Inventors: Lakshmi Sastry-Dent, Zehui Cao, Shreedharan Sriram, Steven R. Webb, Debra L. Camper
  • Patent number: 11198883
    Abstract: Disclosed herein are methods and compositions for parallel or sequential transgene stacking in plants to produce plants with selected phenotypes.
    Type: Grant
    Filed: November 5, 2019
    Date of Patent: December 14, 2021
    Assignees: Dow AgroSciences LLC, Sangamo Therapeutics, Inc.
    Inventors: W. Michael Ainley, Dmitry Y. Guschin, Matthew Hayden, Daniel Isenegger, John Mason, Jeffrey C. Miller, Joseph F. Petolino, Yidong Ran, Tim Sawbridge, German Spangenberg, Steven R. Webb
  • Patent number: 11198884
    Abstract: Transgenic plants and methods for terpenoid production leveraging such transgenic plants are provided. Such transgenic plants may comprise a first heterologous nucleic acid encoding a polypeptide having 3-hydroxy-3-methylglutarylCoA reductase activity and a second heterologous nucleic acid encoding a polypeptide that introduces de novo formation of isopentenyl phosphate in the plant. Such de novo IP production may be achieved through the overexpression of phosphomevalonate decarboxylase in conjunction with 3-hydroxy-3-methylglutarylCoA reductase, which can result in up to a 130-fold increase of terpenoid production as compared to a wild-type plant.
    Type: Grant
    Filed: May 26, 2019
    Date of Patent: December 14, 2021
    Assignee: Purdue Research Foundation
    Inventors: Natalia Doudareva, Joseph Noel, Laura Henry, Suzanne T. Thomas
  • Patent number: 11198885
    Abstract: An expression increasing element comprising a 36 nucleotide DNA sequence that can be used to increase the expression of genes, and in particular to increase the expression of endogenous plant genes, in plants is disclosed. Also disclosed are plants, plant parts, and commodity plant products comprising the expression increasing element along with related methods of using the expression increasing element and plants comprising the expression increasing element.
    Type: Grant
    Filed: March 2, 2021
    Date of Patent: December 14, 2021
    Assignee: Inari Agriculture Technology, Inc.
    Inventor: Hannes Bart Claeys
  • Patent number: 11198886
    Abstract: The invention relates to biotechnology and provides novel recombinant DNA molecules and engineered proteins for conferring tolerance to protoporphyrinogen oxidase-inhibitor herbicides. The invention also provides herbicide tolerant transgenic plants, seeds, cells, and plant parts containing the recombinant DNA molecules, as well as methods of using the same.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: December 14, 2021
    Assignee: Monsanto Technology LLC
    Inventors: Artem G. Evdokimov, Clayton T. Larue, Farhad Moshiri, Joel E. Ream, Xuefeng Zhou
  • Patent number: 11198887
    Abstract: The invention provides a transgenic corn event MON 95379, plants, plant cells, seeds, plant parts, progeny plants, and commodity products comprising event MON 95379. The invention also provides polynucleotides specific for event MON 95379 and methods for using and detecting event MON 95379 as well as plants, plant cells, seeds, plant parts, progeny plants, and commodity products comprising event MON 95379.
    Type: Grant
    Filed: July 29, 2019
    Date of Patent: December 14, 2021
    Assignee: Monsanto Technology LLC
    Inventors: Heather M. Anderson, Sarah L. Brown, Renato A. Carvalho, Ancideriton A. Castro, Katherine M. Dunkmann, Adam J. Evans, Stanislaw Flasinski, Cara L. Griffith, Tianxiang Shen, Todd R. Smith, Heidi M. Windler
  • Patent number: 11198888
    Abstract: Insecticidal proteins exhibiting toxic activity against Coleopteran and Lepidopteran pest species are disclosed, and include, but are not limited to, TIC3668, TIC3669, TIC3670, TIC4076, TIC4078, TIC4260, TIC4346, TIC4826, TIC4861, TIC4862, TIC4863, and TIC-3668-type proteins. DNA molecules and constructs are provided which contain a polynucleotide sequence encoding one or more of the disclosed TIC3668-type proteins. Transgenic plants, plant cells, seed, and plant parts resistant to Lepidopteran and Coleopteran infestation are provided which contain polynucleotide sequences encoding the insecticidal proteins of the present invention. Methods for detecting the presence of the polynucleotides or the proteins of the present invention in a biological sample, and methods of controlling Coleopteran and Lepidopteran species pests using any of the TIC3668-type insecticidal proteins are also provided.
    Type: Grant
    Filed: November 14, 2019
    Date of Patent: December 14, 2021
    Assignee: Monsanto Technology LLC
    Inventors: Gregory J. Bean, David J. Bowen, Catherine A. Chay, Arlene R. Howe, Jason S. Milligan, Yong Yin
  • Patent number: 11198889
    Abstract: A process for the manufacture of butanol, acetone and/or other renewable chemicals is provided wherein the process utilises one or more of the group comprising by-products of the manufacture of malt whisky, such as draff, pot ale and/or spent lees, biomass substrates, such as paper, sludge from paper manufacture and spent grains from distillers and brewers, and diluents, such as water and spent liquid from other fermentations. The process comprises treating a substrate to hydrolyse it and fermenting the treated substrate at an initial pH in the range of 5.0 to 6.0. Also provided is a biofuel comprising butanol manufactured according to the process of the invention.
    Type: Grant
    Filed: February 17, 2020
    Date of Patent: December 14, 2021
    Assignee: Celtic Renewables Limited
    Inventors: Jane Samantha White, Kenneth Alexander Leiper, Martin Tangney, Sandra Messenger
  • Patent number: 11198890
    Abstract: The subject invention relates to a process of preparing (R)-3-hydroxybutyric acid or a salt thereof by one-step fermentation with a nonpathogenic microorganism. The fermentation of (R)-3-hydroxybutyric acid was performed by supplying with certain carbon and nitrogen sources. These microorganisms include a Glutamic acid Bacterium HR057 strain or one type of genetically engineered Corynebacterium Glutamicum.
    Type: Grant
    Filed: August 15, 2019
    Date of Patent: December 14, 2021
    Assignee: NNB Nutrition USA, LLC
    Inventors: Kylin Liao, Wenchao Fan
  • Patent number: 11198891
    Abstract: Provided herein are eukaryotic microorganisms having a simple lipid profile comprising long chain fatty acids (LCFAs). Also provided are compositions and cultures comprising the eukaryotic microorganisms as well as methods of using the eukaryotic microorganisms.
    Type: Grant
    Filed: December 18, 2017
    Date of Patent: December 14, 2021
    Assignee: MARA RENEWABLES CORPORATION
    Inventors: Violeta Ugalde, Zachary Sun, Anthony Windust, Roberto E. Armenta
  • Patent number: 11198892
    Abstract: Provided is a method of producing an oil containing polyunsaturated fatty acids by using Schizochytrium sp. The method comprises: performing fermentation using Schizochytrium sp.; resuspending the resultant cells after fermentation in water, adding cellulase and neutral protease for enzymolysis; mixing the enzymatic hydrolyzate with n-hexane, shaking, extracting, centrifuging, and collecting the n-hexane phase; concentrating the n-hexane phase under reduced pressure to remove the n-hexane, and drying to obtain an oil; performing a first crystallization and a second crystallization, and then performing cold filtration to obtain a liquid oil after the second crystallization; and subjecting the liquid oil to deacidification and decolorization. By regulating fermentation conditions and conducting concentration processing on polyunsaturated fatty acids, the content of eicosapentaenoic acid in the Schizochytrium sp.
    Type: Grant
    Filed: May 20, 2020
    Date of Patent: December 14, 2021
    Assignee: INFINITUS (CHINA) COMPANY LTD.
    Inventors: Zehua Chen, Yong Zhou, Jian Tang, Yonghua Wang, Zheng Xiao, Chenfeng Jing, Dong Liang
  • Patent number: 11198893
    Abstract: Provided is a method for producing an unsaturated fatty acid oxide (e.g. ?3 fatty acid oxide) that is new and has more beneficial features compared to conventional technologies. This method uses a lipoxygenase-containing composition (e.g. a lipoxygenase-containing composition derived from beans) as a lipoxygenase enzyme, and also uses a freezing method with organic solvent extraction. The present invention makes it possible to produce an unsaturated fatty acid oxide (e.g. ?3 fatty acid oxide) efficiently and at a low cost. The present invention also provides a pharmaceutical composition containing an ?3 fatty acid oxide isolated and purified by this method as an active ingredient.
    Type: Grant
    Filed: June 19, 2017
    Date of Patent: December 14, 2021
    Assignee: Bizen Chemical Co., Ltd.
    Inventors: Shiho Saito, Yoshihisa Misawa, Naomichi Baba, Hiroshi Tabata, Tadahiro Tsushima, Jun Fujii
  • Patent number: 11198894
    Abstract: A method for producing an L-amino acid such as L-lysine is provided. An L-amino acid is produced by culturing a bacterium having an L-amino acid-producing ability, which has been modified so that the activity of a carotenoid biosynthesis enzyme is increased, in a medium, and collecting the L-amino acid from the medium.
    Type: Grant
    Filed: February 5, 2019
    Date of Patent: December 14, 2021
    Assignee: AJINOMOTO CO., INC.
    Inventors: Kazuteru Yamada, Ye Zhang, Kenji Abe, Naoki Iwanaga, Ryo Takeshita, Yuri Uehara, Chika Hikichi, Yasuhiro Oota
  • Patent number: 11198895
    Abstract: Fermentative production of L-lysine using an L-lysine excreting bacterium of the species Corynebacterium glutamicum having a completely or partly deleted whiB4 gene is provided.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: December 14, 2021
    Assignee: Evonik Operations GmbH
    Inventors: Georg Thierbach, Frank Schneider, Kornelia Voß, Thomas Bekel
  • Patent number: 11198896
    Abstract: One aspect of the invention provides a nucleic acid encoding a 7?-hydroxysteroid dehydrogenase (7?-HSDH) that catalyzes at least the stereospecific enzymatic reduction of a 7-ketosteroid to the corresponding 7-hydroxysteroid. The enzyme includes a mutation at position 64 of SEQ ID NO:2 or in the corresponding sequence positions of an amino acid sequence derived therefrom with at least 90% sequence identity to SEQ ID NO:2. The mutation at position 64 is the mutation R64X1, wherein X1 represents E, D, T, L, S, P, V, K, C, A, G, Q, F, W, I or Y. The enzyme shows the following property profile in comparison with the 7?-HSDH with SEQ ID NO:2: (a) an increased specific activity (Vmax [U/mg]) for NADPH in the enzymatic reduction of dehydrocholic acid (DHCA) with NADPH as cofactor.
    Type: Grant
    Filed: July 10, 2020
    Date of Patent: December 14, 2021
    Assignee: Pharmazell GmbH
    Inventors: Werner Hummel, Daniel Bakonyi
  • Patent number: 11198897
    Abstract: A method for rapid antibiotic susceptibility testing by tracking sub-micron scale motion of single bacterial cells including obtaining a biological sample from a subject including live bacteria. Different doses of antibiotic are added to a multi-well glass slide and adding portions of the biological sample to the wells. Bacterial cells are tethered onto the surface. The tethered bacterial cells are imaged and tracked. Bacterial sub-micron motion of tethered cells is measured at the different doses. A processor performs statistical analysis on a population of cells for each antibiotic dose to generate an antibiotic dose curve proportional to the motion changes, where the antibiotic dose curve plots data including a decrease in movement over time indicating a proportional effectiveness of an antibiotic applied to a well.
    Type: Grant
    Filed: October 16, 2020
    Date of Patent: December 14, 2021
    Assignee: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Nongjian Tao, Karan Syal
  • Patent number: 11198898
    Abstract: A method for detecting phospholipase D (PLD) activity in a cell, comprising: (i) stimulating endogenous PLD in said cell for said PLD to catalyze a transphosphatidylation reaction between phosphatidylcholine or a derivative thereof and an exogenous functionalized alcohol to form a phosphatidyl alcohol, wherein the functionalized alcohol possesses a first functional group that can react with and form a bond to a functionalized detectable label having a second functional group reactive with the first functional group, and said phosphatidyl alcohol contains said first functional group in available form; (ii) reacting said phosphatidyl alcohol with said functionalized detectable label under conditions where said functionalized detectable label reacts, via its second functional group, with the first functional group to form a linkage between said detectable label and said phosphatidyl alcohol so as to form a labeled phosphatidyl alcohol containing said detectable label; and (iii) detecting said labeled phosphatidy
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: December 14, 2021
    Assignee: CORNELL UNIVERSITY
    Inventors: Jeremy Baskin, Timothy Bumpus, Dongjun Liang
  • Patent number: 11198899
    Abstract: Methods, compositions, and kits for stabilizing both human and microbial deoxyribonucleic acid (DNA) present in complex biological samples, such as feces, are disclosed. In particular, aqueous compositions for stabilizing DNA contained in biological samples at ambient temperature are disclosed, together with associated methods and kits using same. In one aspect, the compositions comprise a chelating agent present at a concentration of at least about 150 mM, and the composition has a pH of at least about 9.5.
    Type: Grant
    Filed: October 7, 2019
    Date of Patent: December 14, 2021
    Assignee: DNA Genotek Inc.
    Inventors: Hyman Chaim Birnboim, Lindsay Pozza, Carlos Alberto Merino Hernandez, Evgueni Vladimirovitch Doukhanine
  • Patent number: 11198900
    Abstract: The invention provides compositions comprising nucleic acid complexes for use in monitoring binding interactions and in measuring association and/or dissociation kinetics, detecting analytes including low concentration analytes, and screening library members. In some instances, the nucleic acid complexes are double-stranded nicked nucleic acids comprising a scaffold nucleic acid hybridized to one or more oligonucleotides. In some instances, a first, a second, a third, and optionally a fourth oligonucleotide are linked to moieties that are known to interact with each other or which are suspected of interacting with each other or of interacting with a common moiety such as an analyte. Changes in topology of the complex are used to determine the binding interactions of the various binding partners.
    Type: Grant
    Filed: November 16, 2015
    Date of Patent: December 14, 2021
    Assignees: Children's Medical Center Corporation, President and Fellows of Harvard College
    Inventors: Mounir Ahmad Koussa, Kenneth Anders Halvorsen, Andrew Ward, Wesley Philip Wong
  • Patent number: 11198901
    Abstract: The present invention relates to a method for forming nano-gaps in graphene. The method may include applying a voltage across a region of graphene such that a nano-gap which extends across the entire width of the graphene is formed, wherein the region across which the voltage is applied may include a point which is the narrowest in the region.
    Type: Grant
    Filed: June 23, 2015
    Date of Patent: December 14, 2021
    Assignee: OXFORD UNIVERSITY INNOVATION LIMITED
    Inventors: George Andrew Davidson Briggs, Jan Andries Mol
  • Patent number: 11198902
    Abstract: Methods and apparatus for the selection or processing of particles sensitive to the application of an external stimulus to rupture/lysis at least one selected particle or the fusion of first and second selected particles are disclosed herein. Particles are organized using a first field of force by selectively energizing electrodes of an array of selectable electrodes having dimensions comparable to or smaller than those of the particles. A first configuration of stresses is applied to the electrodes; and then a second configuration of stresses is applied to the electrodes, so as to create a second field of force, located substantially close to at least one selected particle to be lysated or to a pair of first and second particles to be fused and such as to produce the application of a stimulus suited to produce their lysis or fusion.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: December 14, 2021
    Assignee: Menarini Silicon Biosystems S.p.A.
    Inventors: Nicolò Manaresi, Gianni Medoro, Mélanie Abonnenc
  • Patent number: 11198903
    Abstract: The present invention describes methods for performing higher multiplexed real-time PCR for detection and quantitation of target nucleic acids using tagged hydrolysis probes.
    Type: Grant
    Filed: October 7, 2019
    Date of Patent: December 14, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Igor Kozlov, Amar Gupta, Randall Saiki, Alison Tsan
  • Patent number: 11198904
    Abstract: A substrate for medical test and a gene sequencing method thereof are disclosed. The substrate for medical test includes a micro flow channel substrate, a first substrate, and a second substrate. A side of the micro flow channel substrate facing the first substrate is provided with at least one first micro flow channel, and the first substrate includes a first sample inlet and a first sample outlet which are in communication with the first micro flow channel; a side of the micro flow channel substrate facing the second substrate is provided with at least one second micro flow channel, and the second substrate includes a second sample inlet and a second sample outlet which are communication with the second micro flow channel.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: December 14, 2021
    Assignees: BEIJING BOE OPTOELECTRONICS TECHNOLOGY CO., LTD., BOE TECHNOLOGY GROUP CO., LTD.
    Inventors: Peizhi Cai, Fengchun Pang, Yue Geng, Chuncheng Che, Hailin Xue
  • Patent number: 11198905
    Abstract: The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising DNA from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father. The ploidy state is determined by using a joint distribution model to create a plurality of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. The mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias, for example using massively multiplexed targeted PCR.
    Type: Grant
    Filed: February 20, 2020
    Date of Patent: December 14, 2021
    Assignee: Natera, Inc.
    Inventors: Matthew Rabinowitz, George Gemelos, Milena Banjevic, Allison Ryan, Zachary Demko, Matthew Hill, Bernhard Zimmermann, Johan Baner, Styrmir Sigurjonsson
  • Patent number: 11198906
    Abstract: Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing or nucleic acid amplification. Such properties include enhanced performance with large nucleotide analogs, increased stability, increased readlength, and improved detection of modified bases, and can also include resistance to photodamage, enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, increased yield, increased accuracy, altered speed, increased cosolvent resistance, and the like. Also provided are nucleic acids which encode the polymerases with the aforementioned phenotypes, as well as methods of using such polymerases to make a DNA or to sequence a DNA template.
    Type: Grant
    Filed: March 9, 2020
    Date of Patent: December 14, 2021
    Assignee: Pacific Biosciences of California, inc.
    Inventors: Satwik Kamtekar, Erik Miller
  • Patent number: 11198907
    Abstract: Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: December 14, 2021
    Assignee: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
    Inventors: Jesse Salk, Lawrence A. Loeb, Michael Schmitt
  • Patent number: 11198908
    Abstract: The present disclosure relates to a method for diagnosing or providing information for diagnosing Alzheimer's disease or a brain disease, and a composition and a diagnostic kit for diagnosing Alzheimer's disease or a brain disease using miR-485-3p. The present disclosure enables objective data analysis of the diagnosis of Alzheimer's disease or a brain disease by measuring the expression level of miR-485-3p in blood, minimizes risk to a patient by measuring the concentration of amyloid beta 42 in saliva, and enables quick and accurate diagnosis. Accordingly, the present disclosure is very useful for preventing Alzheimer's disease or a brain disease.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: December 14, 2021
    Assignee: Biorchestra Co., Ltd.
    Inventors: Jin-Hyeob Ryu, Hyun-Jeong Cho
  • Patent number: 11198909
    Abstract: Methods are described for stratifying patient risk for patients with prostate cancer and for providing a treatment recommendation to a patient based on a phosphodiesterase 4D variant 7 (PDE4D7) risk score. A diagnostic kit and a computer program product for the analysis and determination of the PDE4D7 risk score are also described.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: December 14, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Ralf Hoffmann, Eveline Den Biezen-Timmermans, Dianne Arnoldina Margaretha Wilhelmina Van Strijp, Anne Godefrida Catharina Van Brussel, Marcia Alves De Inda, Johannes Baptist Adrianus Dionisius Van Zon, Janneke Wrobel
  • Patent number: 11198910
    Abstract: Provided herein, among other things, are various compositions and methods for analyzing chromatin. In some embodiments, the composition may comprise a mixture of a nicking enzyme, four dNTPs, at least one labeled dNTP and, optionally, a polymerase. In some embodiments, this method may comprise: obtaining a sample comprising chromatin, reacting the sample with the composition to selectively label the open chromatin in the sample, and analyzing the labeled sample.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: December 14, 2021
    Assignee: New England Biolabs, Inc.
    Inventors: Chaithanya Ponnaluri, Hang-Gyeong Chin, Pierre O. Esteve, Sriharsa Pradhan
  • Patent number: 11198911
    Abstract: Products, systems, and methods for classifying human colorectal cancer into a consensus molecular subtype (CMS) and for assessing risk of recurrence based on CMS scores and based on risk scores derived from abbreviated gene expression profiles, for determining suitable treatment protocols for human colorectal cancer patients based on the determined CMS classification and based on the determined risk of recurrence, and for administering the suitable treatment protocols.
    Type: Grant
    Filed: March 7, 2019
    Date of Patent: December 14, 2021
    Assignee: UNIVERSITY OF NOTRE DAME DU LAC
    Inventor: Steven Buechler
  • Patent number: 11198912
    Abstract: Embodiments of the invention include a system and method of using biomarkers in the diagnosis of lung cancer. A subject can be screened for lung cancer based on expression of specific mRNAs, miRNAs or the detection of a nucleic acid, protein, peptide or other biological molecule in blood, serum or plasma. Embodiments include 29 specific miRNAs for use as biomarkers to screen or distinguish healthy individuals from individuals affected with the disease, including a lung cancer, along with 81 additional nucleic acids, proteins or peptides for use as biomarkers to screen or distinguish healthy individuals from individuals affected with the disease, including a lung cancer. Levels of more than one of the mRNAs, miRNAs or proteins can be scored and compared to one or more threshold values to diagnose or determine the prognosis of lung cancer. Embodiments also include a kit for screening healthy subjects from subjects affected with the disease.
    Type: Grant
    Filed: August 26, 2020
    Date of Patent: December 14, 2021
    Assignee: Liquid Lung DX
    Inventors: Patrick Lilley, Martin J. Keiser, III
  • Patent number: 11198913
    Abstract: Provided are compositions, kits, and methods for the identification of Listeria. In certain aspects and embodiments, the compositions, kits, and methods may provide improvements in relation to specificity, sensitivity, and speed of detection.
    Type: Grant
    Filed: October 25, 2019
    Date of Patent: December 14, 2021
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Michael R. Reshatoff, Kristin W. Livezey, James J. Hogan
  • Patent number: 11198914
    Abstract: A raw material for direct reduction which is reduced in a shaft furnace includes a raw material, and a coating layer which coats the raw material and has a porosity of 20 volume % or more.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: December 14, 2021
    Assignee: NIPPON STEEL CORPORATION
    Inventors: Moritoshi Mizutani, Tsunehisa Nishimura
  • Patent number: 11198915
    Abstract: A method of quenching a press hardenable steel is provided. The method includes an initial step of die quenching a part stamped within a stamping die followed by a partial quenching after the initial step of die quenching. In various methods, the press hardenable steel is a 36MnB5 grade steel and/or the initial step of die quenching is performed at a temperature of approximately 200° C.±10° C. in a die configured for 36MnB5 grade steel. At least one method further includes opening the die followed by the partial quenching, the partial quenching comprising spraying a cooling liquid onto the part to reduce a temperature of the part below approximately 130° C.±10° C., with the option of spraying to reduce the temperature of the part below approximately 100° C.±10° C.
    Type: Grant
    Filed: February 8, 2018
    Date of Patent: December 14, 2021
    Assignee: Ford Motor Company
    Inventors: Raj Sohmshetty, Constantin Chiriac, Mikhail Minevich, Jason Balzer, S. George Luckey, Jr.
  • Patent number: 11198916
    Abstract: Further lower iron loss can be achieved in a grain-oriented electrical steel sheet including: a predetermined film mainly composed of forsterite on a front and back surfaces thereof; and a plurality of grooves on the front surface thereof, in which the plurality of grooves have an average depth of 6% or more of a thickness of the steel sheet and are spaced a distance of 1 mm to 15 mm from respective adjacent grooves, the steel sheet has a specific magnetic permeability ?r15/50 of 35000 or more when subjected to alternating current magnetization at a frequency of 50 Hz and a maximum magnetic flux density of 1.5 T, and the steel sheet includes isolated parts having a presence frequency of 0.3/?m or less, the isolated parts being separated from a continuous part of the film in an interface between the steel sheet and the film in a cross section orthogonal to the rolling direction of the steel sheet.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: December 14, 2021
    Assignee: JFE STEEL CORPORATION
    Inventors: Kunihiro Senda, Makoto Watanabe, Seiji Okabe, Souichiro Yoshizaki
  • Patent number: 11198917
    Abstract: Provided is a method for nitriding a grain-oriented electrical steel sheet which is very useful in obtaining excellent magnetic properties with no variation, that enables generating glow discharge between positive electrodes and negative electrodes disposed in a nitriding zone and irradiating the generated plasma to a strip to perform appropriate nitriding.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: December 14, 2021
    Assignee: JFE STEEL CORPORATION
    Inventors: Hiroshi Matsuda, Hideyuki Takahashi, Hiroi Yamaguchi, Yasuyuki Hayakawa, Yukihiro Shingaki, Takashi Terashima
  • Patent number: 11198918
    Abstract: The present invention has as its object to provide thickness 60 ?m or less ultra-thin stainless steel foil which secures high thickness precision and simultaneously secures plastic deformability and good elongation at break, that is, secures good press-formability (deep drawability). The present invention solves this problem by ultra-thin stainless steel foil which has three or more crystal grains in a thickness direction, has a recrystallization rate of 90% to 100%, and has a nitrogen concentration of a surface layer of 1.0 mass % or less. For this reason, there is provided a method of production of stainless steel foil comprising rolling stainless steel sheet, then performing final annealing and making a thickness 5 ?m to 60 ?m, wherein a rolling reduction ratio at rolling right before final annealing is 30% or more, a temperature of final annealing after rolling is 950° C. to 1050° C. in the case of austenitic stainless steel and 850° C. to 950° C.
    Type: Grant
    Filed: February 16, 2015
    Date of Patent: December 14, 2021
    Assignee: NIPPON STEEL CHEMICAL & MATERIAL CO., LTD.
    Inventors: Hiroto Unno, Shinichi Terashima, Toru Inaguma, Koichi Nose, Naoki Fujimoto, Naoya Sawaki, Shuji Nagasaki
  • Patent number: 11198919
    Abstract: A system for air quenching a heat treated element comprises a tubular component, an internal air quench device moveably disposed within the interior of the tubular component, and an external air quench device moveably disposed about the tubular component. The internal air quench device comprises a nozzle configured to induce an airflow within the tubular component. The external air quenching device can comprise an annular ring disposed about the tubular component that is configured to generate a cone of air about the tubular component.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: December 14, 2021
    Assignee: NATIONAL OILWELL VARCO, L.P.
    Inventors: David Martin Ellis, Luis Marcos Cadena, Christopher Alan Conrey, Daryl Stevenson
  • Patent number: 11198920
    Abstract: Disclosed is a method for manufacturing high-carbon bearing steel, which include: heating a billet at a temperature of about 950 to 1,050° C. for about 70 to 120 minutes, rolling the billet to manufacture a wire rod, winding the wire rod to manufacture a wire rod coil, cooling the wire rod coil, and subsequently heat treating the wire rod coil for spheroidizing and carbonitriding, respectively. The bearing steel may include an amount of about 0.9 to 1.3 wt % of carbon (C), an amount of about 1.1 to 1.6 wt % of silicon (Si), an amount of about 1.0 to 1.5 wt % of manganese (Mn), an amount of about 1.5 to 1.9 wt % of chromium (Cr), an amount of about 0.2 to 0.6 wt % of nickel (Ni), an amount of about 0.1 to 0.3 wt % of molybdenum (Mo), and the balance iron (Fe) based on the total weight thereof.
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: December 14, 2021
    Assignees: Hyundai Motor Company, Kia Motors Corporation, Hyundai Steel Company
    Inventors: Jae-Yoon Hwang, Min-Woo Kang, Shin-Woong Jeong, Soon-Jae Won, Sang-Min Song, Seung-Hyun Hong, Min-Woo Kang
  • Patent number: 11198921
    Abstract: The present invention relates to a process for dissolving metals in perhalide containing ionic liquids, and to the extraction of metals from mineral ores; the remediation of materials contaminated with heavy, toxic or radioactive metals; and to the removal of heavy and toxic metals from hydrocarbon streams.
    Type: Grant
    Filed: April 2, 2019
    Date of Patent: December 14, 2021
    Assignee: Petroliam Nasional Berhad (Petronas)
    Inventors: Robin Don Rogers, John Holbrey
  • Patent number: 11198922
    Abstract: A system for collecting mercury from feed material that can be tailings comprises: a water inlet for forming a slurry containing the tailings; at least one screen for separating tailings greater than ¼ inch in diameter from the slurry to form a screened slurry; a rotatable collection chamber containing a plurality of plates, a drive for rotating the collection chamber for collecting mercury on the plates to provide a discharge material comprising water and treated tailings, the treated tailings containing less mercury than in the feed material.
    Type: Grant
    Filed: October 29, 2020
    Date of Patent: December 14, 2021
    Inventor: Paul Milton Clift
  • Patent number: 11198923
    Abstract: Alloys comprised of a refined microstructure, ultrafine or nano scaled, that when reacted with water or any liquid containing water will spontaneously and rapidly produce hydrogen at ambient or elevated temperature are described. These metals, termed here as aluminum based nanogalvanic alloys will have applications that include but are not limited to energy generation on demand. The alloys may be composed of primarily aluminum and other metals e.g. tin bismuth, indium, gallium, lead, etc. and/or carbon, and mixtures and alloys thereof. The alloys may be processed by ball milling for the purpose of synthesizing powder feed stocks, in which each powder particle will have the above mentioned characteristics. These powders can be used in their inherent form or consolidated using commercially available techniques for the purpose of manufacturing useful functional components.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: December 14, 2021
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Anit K. Giri, Anthony J. Roberts, Billy C. Hornbuckle, Scott M. Grendahl, Kristopher A. Darling
  • Patent number: 11198924
    Abstract: A fibre reinforced polymer (FRP) composite structure incorporates a woven preform containing tows of carbon or other advanced fibres and wires of shape memory alloy (SMA). The SMA wires are capable of absorbing much larger amounts of strain energy than the conventional components of FRP composites and hence enhance the impact resistance of the structure. The woven form incorporates the SMA into the structure in an optimum manner in terms of handling and performance.
    Type: Grant
    Filed: October 20, 2005
    Date of Patent: December 14, 2021
    Inventors: Lakshman Chandrasekaran, Andrew David Foreman
  • Patent number: 11198925
    Abstract: The present disclosure provides Al—Si—Mg aluminum alloys comprising a deliberate addition of Mn between 0.05-0.40 weight percent to increase at least one tensile property (such as the yield strength) of an aluminum product comprising such alloy. The Al—Si—Mg alloy comprises, in weight percent, 5-9% Si, 0.35-0.75% Mg, 0.05-0.4% Mn, less than 0.15% Fe, up to 0.15% Ti, 0.005-0.03% Sr and the balance being aluminum and unavoidable impurities, wherein the unavoidable impurities may be present in an amount of up to 0.05% each and up to 0.15% total. The present disclosure provides a foundry ingot comprising the above Al—Si—Mg aluminum alloy, a process for making the above Al—Si—Mg aluminum alloy and an aluminum alloy obtainable by said process.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: December 14, 2021
    Assignee: Rio Tinto Alcan International Limited
    Inventors: Francis Breton, Bruno Bourassa, Alexandre Maltais, Clément Boudreault, Dany Tremblay
  • Patent number: 11198926
    Abstract: In one aspect of the invention, an alloy includes a first element comprising magnesium (Mg), titanium (Ti), zirconium (Zr), chromium (Cr), or nickelaluminum (NiAl), a second element comprising lithium (Li), calcium (Ca), manganese (Mn), aluminum (Al), or a combination thereof, and a third element comprising zinc (Zn). According to the invention, nanoscale precipitates is produced in the magnesium alloy by additions of zinc and specific heat-treatment. These precipitates lower the energy for dislocation movements and increase the number of available slip systems in the magnesium alloy at room temperature and hence improve ductility and formability of the magnesium alloy.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: December 14, 2021
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Morris E. Fine, Semyon Vaynman, Evan T. Hunt, Akio Urakami, Yip-Wah Chung, Johannes Weertman
  • Patent number: 11198927
    Abstract: The present invention relates to Nb-based refractory alloys that are less expensive and less dense than some of the current Nb-based refractory alloys, have similar or better ductility, strength specific yield strength and oxidation resistance when compared to current Nb-based refractory alloys. Such Nb-based refractory alloys typically continue to be compatible with current coating systems for Nb-based refractory alloys. Such Nb-based refractory alloys are disclosed herein.
    Type: Grant
    Filed: September 26, 2019
    Date of Patent: December 14, 2021
    Assignee: United States of America as represented by the Secretary of the Air Force
    Inventors: Kevin J. Chaput, Oleg M. Senkov, Todd M. Butler
  • Patent number: 11198928
    Abstract: A method for producing a dual phase steel sheet is provided. The method includes providing a dual phase hot rolled steel sheet having a microstructure including ferrite and martensite and a composition including 0.1 to 0.3 wt. % C, 1.5 to 2.5 wt. % Si and 1.75 to 2.5 wt. % Mn. The steel sheet is annealed at a temperature from 750 to 875° C., water quenched to a temperature from 400 to 420° C. and subject to overaging at the temperature from 400 to 420° C. to convert the martensite in the hot rolled steel sheet to tempered martensite. The overaging is sufficient to provide the hot rolled steel sheet with a hole expansion ratio of at least 15%.
    Type: Grant
    Filed: November 15, 2019
    Date of Patent: December 14, 2021
    Assignee: ArcelorMittal
    Inventors: Hyun Jo Jun, Narayan S. Pottore, Nina Michailovna Fonstein
  • Patent number: 11198929
    Abstract: Provided is a hot rolled steel sheet comprising a predetermined composition wherein the hot rolled steel sheet comprises a dual structure of, by area fraction, a structural fraction of a martensite phase of 10 to 40% and a structural fraction of a ferrite phase of 60% or more, has an average grain size of ferrite grains of 5.0 ?m or less, and has a coverage rate of martensite grains by ferrite grains of more than 60%. Also provided is a method for producing a hot rolled steel sheet comprising rolling a steel sheet wherein the respective rolling loads of the final three rolling stands are 80% or more of an immediately previous rolling stand and an average value of these rolling temperatures is 800 to 950° C., and forcibly cooling, then coiling the steel sheet wherein the forcibly cooling includes cooling started within 1.5 seconds after the rolling ends and cooling the steel sheet by a 30° C./second or more average cooling rate down to 600 to 750° C.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: December 14, 2021
    Assignee: NIPPON STEEL CORPORATION
    Inventors: Takeshi Toyoda, Tetsuya Hirashima, Riki Okamoto