Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte.

Abstract: Methods and Devices to monitor the level of at least one analyte are provided.

Abstract: An interchangeable sensor that can perform detection via spectroscopic techniques using non-optical frequencies such as in the radio or microwave frequency bands of the electromagnetic spectrum. The interchangeable sensor is removably disposable on a user wearable sensing assembly that can be worn by a user for non-invasively detecting an analyte in the user. The sensor can also be removably installed on a non-user wearable sensing assembly for performing a detection function using the sensor installed on the non-user wearable sensing assembly.

Abstract: A coupling tool for coupling together an electronics unit and a base unit of a wearable device for continuous analyte monitoring includes a carrier comprising a receiving feature and a carrier retention device, the carrier retention device configured to retain an electronics unit adjacent the receiving feature. The coupling tool also includes an activator including: a first member at least partially receivable in the receiving feature and a contact member configured to release the electronics unit from the carrier retention device in response to movement of the activator relative to the carrier. The coupling tool is in a locked configuration when the carrier retention device is configured to retain the electronics unit, and the coupling tool is in an unlocked configuration when the carrier retention device is configured to release the electronics unit from the carrier retention device. Other embodiments and methods are also disclosed.

Abstract: Measurement of target analytes is carried out with an enzyme-based sensor. The enzyme hydrogel is protected by a porous layer of a metallic material. The size of the pores is small enough to prevent degradation of the enzyme layer caused by the immune system of an organism, but large enough to allow transfer of molecules that participate in the electrochemical reaction allowing the enzyme to detect the target analytes.

Abstract: Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.

Abstract: A blood collecting syringe that advantageously indicates whether the needle has correctly entered the blood vessel, typically a vein. Correct placement is determined when the user observes flashback, or blood entering the syringe. Flashback can be undetected in certain situations due to lack of pressure in the patients vascular system, typically the venous system. This syringe includes an internal, luminal region having an adjustable volume. When desired, the initial luminal volume can be increased to create a partial vacuum. This partial vacuum results in an improved detection of flashback.

Abstract: A biological fluid sampling device includes a rigid body extending along a body axis and having a first end portion, a second end portion, and an intermediate portion extending between the first end portion and the second end portion. The second end portion includes a plurality of fins, with each fin extending radially outward relative to the body axis. Adjacent ones of the plurality of fins at least partially define a cavity therebetween. The device further includes an absorbent body connected to the rigid body and extending from the second end portion in a direction substantially parallel to the body axis, with the absorbent body being configured to absorb a biological fluid.

Abstract: An apparatus includes a housing, a fluid reservoir, a flow control mechanism, and an actuator. The housing defines an inner volume and has an inlet port that can be fluidically coupled to a patient and an outlet port. The fluid reservoir is disposed in the inner volume to receive and isolate a first volume of a bodily-fluid. The flow control mechanism is rotatable in the housing from a first configuration, in which a first lumen places the inlet port is in fluid communication with the fluid reservoir, and a second configuration, in which a second lumen places the inlet port in fluid communication with the outlet port. The actuator is configured to create a negative pressure in the fluid reservoir and is configured to rotate the flow control mechanism from the first configuration to the second configuration after the first volume of bodily-fluid is received in the fluid reservoir.

Abstract: The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.

Abstract: A system predicts the mental state of a user using a variety of contact or contactless sensors that measure heart rate, breathing or other data of the user. The mental state may be flow, overload, underload, stress, attention, motivation, valence, arousal, etc. While performing a game-playing task the difficulty of the task is adjusted based upon the predicted mental state of the user. A classifier for classifying a mental state is trained using event marking and ground truth data. Computer usage generates event markers. Game playing is used to simulate a mental state. Interruptions of a user are prevented when the user enters a flow, focused, or effortful attention state by classifying that state and indicating physically or electronically that the user should not be interrupted. Interruptions of a user are also prevented when the user enters a mind wandering state by classifying or predicting that state and indicating physically or electronically that the user should not be interrupted.

Abstract: Example devices and techniques for sensing a parameter of a substance of interest are disclosed. An example catheter includes an elongated body defining a lumen. The lumen is configured to receive or house an oxygen sensing element. When the oxygen sensing element is located in a proximal portion of the lumen, the oxygen sensing element is configured to sense an amount of dissolved oxygen in a fluid external to the lumen. The catheter is configured to block ingress of the fluid into the lumen while the oxygen sensing element senses the amount of dissolved oxygen.

Abstract: A method of manufacturing a micro-molded electrode having multiple individually addressable sensors along a shaft can include forming a recess in a mold substrate, depositing a structural material therein, depositing a conductive material at specific locations, providing a coating, and removing the mold substrate. A micro-molded electrode having a base tapering to at least one shaft can include an electrode substrate, multiple individually addressable sensors, and a coating.

Abstract: Biometric information about a person may be collected and analyzed to gain insight into the person's physical and/or emotional conditions. The collection and analysis may be performed using a uniquely designed sensing device that includes multiple sets of sensors configured to collect EEG, EOG, EMG, EDA, and/or PPG signals from the person's head and/or facial areas. The sensing device may include a multi-layered facepad and may be coupled to a VR/AR headset and/or a scalp engagement apparatus to monitor the person's physiological and/or neural reactions to audio/visual stimuli.

Abstract: A biosensor having a satisfactory wearing comfort is provided, taking the compressive elastic modulus, the thickness and the planar area of the component into account. The biosensor includes a substrate having a rigidity K of 3.0 N·mm2 or less expressed by following formula (1), and a component provided on a first main surface of the substrate, the component having a rigidity that satisfies following formula (2) and is equal to or greater than a predetermined value, K=ET3/12 ??(1) K?6.34×1014×S?10.6 ??(2) where E and T in formula (1) denote a compressive elastic modulus at 23° C. expressed in megapascals (MPa), and a thickness expressed in millimeters (mm), respectively. In formula (2), K denotes the rigidity expressed by formula (1) in newton millimeters squared (N·mm2), and S denotes a planar area expressed in square centimeters (cm2).

Abstract: An electrocardiogram (ECG) measurement device for a vehicle is provided. The ECG measurement device includes an impedance compensator that corresponds to an electrode in contact with a body of a driver and configured to compensate an impedance of each of electrode signals received from the electrode. An electrode selector sequentially selects the electrode signals in response to receiving the electrode signals from the electrode. A differential amplifier differentially amplifies the electrode signals. In particular, each electrode signal has the compensated impedance. Additionally, a signal quality evaluator evaluates quality of an ECG signal output from the differential amplifier and a compensation controller then adjusts an impedance compensation value of each of the impedance compensators as a result of evaluating the quality of the ECG signal.

Abstract: In various examples, a component for a medical device is described. The component includes a conductor wire including a connection portion. An electrode is formed from a conductive tube. The conductive tube is compressed at least partially around the connection portion of the conductor wire to at least partially surround and couple to the connection portion.

Abstract: A biological information measurement apparatus according to an embodiment of the present disclosure includes one or a plurality of measurement channels to be brought into contact with a biological body, and a reference channel to be brought into contact with the biological body. The biological information measurement apparatus further includes a differential circuit that generates a biological signal corresponding to a difference between a measurement signal obtained from the measurement channel and a reference signal obtained from the reference channel, and a switch mechanism that switches contact impedance between the biological body and each of the measurement channel and the reference channel.

Abstract: The present invention provides a circuitry of a biopotential acquisition system comprising an input node, an ETI transmitter and an ADC. The input node is coupled to an electrode of the biopotential acquisition system, and the electrode is used to be in contact with a human body. The ETI transmitter is configured to generate a transmitter signal to the input node. The ADC is coupled to the input node, and is configured to process an input signal from the input node to generate a digital signal, wherein each of the input signal and the digital signal comprises components of an ECG signal and an ETI signal.

Abstract: There is provided an electroencephalogram (EEG) signal amplifier for boosting impedance in an analog front end (AFE). The EEG signal amplifier includes a first feedback loop configured to amplify an EEG signal, a second feedback loop connected to the first feedback loop and configured to amplify an input impedance, and an attenuator included in the second feedback loop.

Abstract: A system and method for detecting and verifying bradycardia/asystole episodes includes sensing an electrogram (EGM) signal. The EGM signal is compared to a primary threshold to sense events in the EGM signal, and at least one of a bradycardia or an asystole is detected based on the comparison. In response to detecting at least one of a bradycardia or an asystole, the EGM signal is compared to a secondary threshold to sense events under-sensed by the primary threshold. The validity of the bradycardia or the asystole is determined based on the detected under-sensed events.

Abstract: Provided are an electrocardiogram signal processing apparatus and method for identifying supraventricular arrhythmia and ventricular arrhythmia particularly to determine, by using the morphological similarity, complexity value, and R-R interval length of an electrocardiogram signal of a subject, regardless of whether or not the subject has supraventricular arrhythmia or ventricular arrhythmia.

Abstract: The present disclosure relates to a system and method capable of capturing, processing and analyzing electroencephalography (EEG) signals, including features, patterns or signatures with relevance to diagnosis, prognosis, risk stratification or other clinically relevant interpretation, by means of a low-profile head-mounted wireless recording device that may be rapidly applied to the individual being examined. The head-mounted recording device is comprised of an array of electrode elements that contact the subject's forehead, a docking site and an acquisition device that receives, processes, and transmits the EEG data. In one embodiment, the device simultaneously collects additional data, including but not limited to accelerometer data, heart rate, sound level, light level, temperature and/or pulse oximetry.

Abstract: A technique for using biofeedback to facilitate and quantify accurate patient assessments includes receiving brainwave activity readings of a provider and a recipient(s) before, during, and post an interaction between the provider and the recipient(s) for a procedure. The brainwave readings being indicative of the state of mind of the provider and the recipient(s). The provider performs a therapeutic or knowledge transfer to the patient(s)/recipient(s) and evaluates the impact/efficacy of the procedure on them. The system correlates the collected brainwave activity signals of the provider and the recipient(s) to determine the efficacy of the therapeutic or knowledge transfer procedure. The brainwave activity signals are collected using a headgear based on an electroencephalogram system and an electromyography system.

Abstract: The disclosed apparatus, systems and methods relate to ocular surface potential difference (OSPD) measurement, and in particular, to the devices, methods, and design principles allowing for such measurement and the use of the measured OSPD in various research and clinical settings.

Abstract: A seizure detection system including one or more circuits configured to receive an electroencephalogram (EEG) signal generated based on electrical brain activity of a patient. The one or more circuits are configured to identify candidate seizures with a statistical analysis that identifies the candidate seizures based on changes in non-linear features of the EEG signal, determine to switch from identifying the candidate seizures with the statistical analysis to an artificial intelligence model, and switch from identifying the candidate seizures with the statistical analysis to identifying the candidate seizures based on the artificial intelligence model with the EEG signal.

Abstract: A system or method for pressure related skin injury risk assessment and treatment including measuring extrinsic and intrinsic pressure on skin of the patient through assigned ratings responsive to the pressure on skin measurement, measuring oxygenation of the patient and assigning a rating responsive to the oxygenation measurement, measuring perfusion of the patient and assigning a rating responsive to the perfusion measurement, summing the pressure on skin, oxygenation and perfusion ratings to obtain a POP Box score, determining a risk of pressure related skin injury for the patient in response to the POP Box score, and determining or selecting a recommended treatment from among a plurality of recommended treatments for the patient in response to the determined risk of pressure related skin injury.

Abstract: An apparatus (12) for placement on the abdomen of a subject for monitoring uterine contractions. The apparatus includes a light source (16) and a light detector (18) which communicate light via a reflection surface (22) arranged facing the light source and light detector. One of the light source and light detector is fixed in position relative to the reflection surface, while the other is arranged to be displaceable relative to the reflection surface responsive to movement of the subjects abdomen caused by contractions. The movement of the moveable component is such as to cause a variation in the light intensity received at the light detector, the variation in light intensity being representative of the uterine contractions.

Abstract: A method for characterizing cutaneous pigmentary disorders in an individual which includes: for each pigmentary disorder: on a date tkm acquiring 2D images of a pigmentary disorder from a plurality of angles and reconstructing at least one 3D image; storing the images in a first folder; on the basis of the images, calculating parameters of the pigmentary disorder, and storing in a second folder; evaluating the parameters and storing in a third folder; iterating at least one of the four preceding steps on multiple dates, and for each iteration: comparing the data for at least one period and identifying the changes; storing in a fourth folder per period; for each fourth folder, grouping the folders together in a fifth folder defining a snapshot of the pigmentary disorder; aggregating the fifth folders in a sixth folder defining a dynamic profile of the pigmentary disorder; iterating the preceding steps to obtain a sixth folder for each additional pigmentary disorder; and generating, for the individual, a knowle

Abstract: The present invention relates to a medical device and a method for assessing and monitoring epithelial barrier function in vivo of a subject using electrical impedance measurements. The method comprises initiating an impedance measurement session including passing an electrical current through the skin of the subject to obtain values of skin impedance of a target tissue region, said data comprising at least one impedance value measured in the target tissue region at different tissue layers. Further, an evaluation procedure is applied for analyzing the epithelial barrier function in the target tissue region based on the measured data set of impedance values for the target tissue region at different tissue layers. The procedure evaluates the obtained data set of impedance values to provide an outcome indicating a status of the epithelial barrier function of the subject.

Abstract: The present disclosure provides methods of identifying a patient in need of pressure ulcer treatment and treating the patient with clinical intervention selected based on sub-epidermal moisture values. The present disclosure also provides methods of stratifying groups of patients based on pressure ulcer risks and methods of reducing incidence of pressure ulcers in a care facility.

Abstract: A system and method for generating biofeedback using feedback signals created by at least one media device. A subject person is monitored to obtain biometric data. The biometric data is used to generate a biometric waveform. The biometric waveform is used to generate control signals. The control signals are used to regulate audio signals, lighting, audiovisual imagery and/or auxiliary devices so that these feedbacks are altered to represent some waveform characteristic embodied by the biometric waveform. The subject person will hear and/or see the feedback and will better be able to control their body and mind.

Abstract: A method for classifying movement of a user during a period of low activity, such as sleep, is provided. The method includes providing a wearable device having a motion sensor; obtaining sensor data from the motion sensor in a buffer having raw sensor data points within a time period; determining whether at least part of the raw sensor data points in the first buffer meets a predefined condition based on a stationarity of motion in the raw sensor data; deriving a low-temporal resolution representation of the raw sensor data points in the first buffer when the at least part of the plurality of raw sensor data points in the first buffer meets the predefined condition based on stationarity; adapting the low-temporal resolution representation based on an estimated effect of a phenomenon on the low-temporal resolution representation; and classifying movement of the user based on the adapted low-temporal resolution representation.

Abstract: A method for monitoring health of a person by a health monitoring system includes: measuring movement data of a person using a wearable health monitoring device, determined whether the person is in a deep sleep mode based on the movement data, automatically measuring a respiratory rate of the person that is in a deep sleep mode, determining that the person is in one of a plurality of respiration zones, measuring at least one of a body temperature, an ambient temperature, a sleeping position, a smoke or carbon monoxide level, a video, and images of the person, and automatically producing an alarm signal if a predetermined criterion is met based on the respiration zone and at least one of the body temperature, the ambient temperature, the smoke level, the carbon monoxide level, a sleeping position, or the images of the person.

Abstract: This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with an immunosuppressant.

Abstract: In a method for generating a biomarker quantifying spatial homogeneity of a medical parameter map, A) the parameter map is provided, B) at least two parameter classes are provided, where each parameter value is to be assigned to a parameter class, C) a sub-area of the examination area is selected, D) in each case, a frequency value for each parameter class for the sub-area is determined, E) a heterogeneity indicator for the sub-area is determined based on the frequency values of the parameter classes, F) further heterogeneity indicators are generated for at least two further sub-areas that are at least partially different from one another, G) a statistical homogeneity value is determined by statistical evaluation of the heterogeneity indicator of the sub-area and the further heterogeneity indicators, and H) the statistical homogeneity value is provided as a biomarker.

Abstract: An electronic device includes a sensor capable of detecting pulsation in a target region of a subject, a pressing portion to be pressed toward the target region, and an elastic member interposed between the sensor and the pressing portion.

Abstract: A face mask including a body portion configured to be secured to a user's face and cover a mouth and nasal passages of the user, a processor, and an oximetry sensor operably positioned at the user's nose when the body portion is secured to the user's face. In some implementations, the oximetry sensor includes at least one emitter configured to emit light into tissue of the user's nose and at least one detector configured to detect at least a portion of the emitted light after passing through the tissue and transmit one or more signals to the processor responsive to detected light. In some implementations, the processor determines one or more physiological parameters based on the one or more signals transmitted by said at least one detector. In some implementations, the face mask is configured to wirelessly transmit the one or more physiological parameters to a mobile computing device.

Abstract: A method for monitoring health of a person by a health monitoring system includes determining if a person wearing a wearable health monitoring device is sleeping or not based on movement data, measuring sleep movements of the person to determine whether the person is in a deep sleep mode when the person is determined to be sleeping, measuring bio-vital signals of the person and at least one of a posture of the person or environmental parameters when the person is determined to be in the deep sleep mode, and automatically producing an alarm signal if a predetermined criterion is met based on the bio-vital signals and at least one of a posture of the person or the environmental parameters.

Abstract: A direct current (DC) motor for operation in an external magnetic field may include a rotor which is rotatable about a rotation axis and has at least two windings, at least four continuous rotary transmitters, wherein two rotary transmitters are associated with each of the windings and are configured to supply the associated winding with direct current, an angle sensor which is configured to determine the angular position of the rotor, and a controller configured to control the current feed to at least one of the windings dependent upon the angular position of the rotor. The motor is oriented relative to an external magnetic field during operation so that the rotation axis extends transversely to the external magnetic field.

Abstract: An Electrocardiography (ECG) noise-filtering device is provided in the invention. The ECG device includes a filter and a calculation circuit. The filter receives a first ECG signal and performs a Savitzky-Golay algorithm to generate a second ECG signal. The calculation circuit is coupled to the filter to receive the second ECG signal and processes the second ECG signal according to a Stationary Wavelet Transform (SWT) algorithm to generate a noise signal, and subtracts the noise signal from the second ECG signal to filter the noise signal in the first ECG signal.

Abstract: A method for providing a thermal feedback, performed by a feedback device. The feedback device outputs the thermal feedback, by transmitting a heat generated by a thermoelectric element, to a user via a contact surface contacting with a body part of the user. The method may include obtaining a feedback start message including a type of the thermal feedback, and when the type of the thermal feedback is a thermal grill feedback, outputting the thermal grill feedback by performing a thermal grill operation in which a heat generating operation and a heat absorbing operation is combined. The outputting of the thermal grill feedback may include applying a forward power to the thermoelectric element to perform the heat generating operation, applying a reverse power of which a current direction is opposite to the forward power to the thermoelectric element to perform the heat absorbing operation, and repeating the applying the forward power and the applying the reverse power alternatively.

Abstract: A controller comprising at least one processor of an information processing apparatus executes: acquiring first information about a condition of a body of a user; and acquiring second information about a condition of an environment around the user. Then, the controller of the information processing apparatus executes: executing a predetermined judgment process for judging whether predetermined symptoms occur on the user within a predetermined period, based on the first information and the second information; and notifying the user that predetermined medicine for coping with the predetermined symptoms is to be used, if a positive judgment is made in the predetermined judgment process.

Abstract: A method of determining regularity of a bio-signal is provided. The method of determining regularity of a bio-signal according may include acquiring a plurality of pulse waveforms of the bio-signal, acquiring a plurality of slope waveforms corresponding to the plurality of pulse waveforms, binarizing the plurality of slope waveforms, acquiring synchronization information of the plurality of pulse waveforms based on binarizing the plurality of pulse waveforms; acquiring a synchronization rate of a reference interval based on the synchronization information, and determining whether the bio-signal is regular or irregular based on the synchronization rate of the reference interval.

Abstract: An information management system including a measuring device and an information terminal. In the measuring device, a first communication means transmits identification information identifying the measuring device, and a first output means outputs a unique pattern in a human-perceivable manner at least when the identification information is transmitted.

Abstract: A physiological parameter sensing system receives signals from (on includes) a first physiological parameter sensor and an activity monitor. The first physiological parameter signal is used to determine when additional physiological parameter sensing is recommended and an alert is then generated. The alert has characteristics which depend on the type and/or level of activity currently being undertaken by the user. In this way, the alert can be selected so that it is perceived by the user but without being an annoyance.

Abstract: A patient support apparatus includes a sensor capable of detecting vital signs, setting acceptable limits for the vital signs, and includes structures for monitoring the vital signs and providing local and/or remote indications to caregivers if the vital signs fall outside of acceptable limits.

Abstract: A method and apparatus for displaying operation of image positioning, an electronic device, and a storage medium are provided. The method includes: in response to a selection operation for any one of a plurality of operation areas, obtaining an operation position; triggering a corresponding operation manner at the operation position; obtaining, according to a correspondence relationship for the operation position among the plurality of operation areas, a linkage display result, based on the operation manner, for the plurality of operation areas.

Abstract: Embodiments include a x-ray imaging system, apparatus, and method for use thereof. The apparatus comprises a first vertical column attached to a floor surface and configured to support an x-ray source; a second vertical column attached to the floor surface at a first distance opposite the first column and configured to support an x-ray imaging detector; and a positioning system configured to control vertical and angular movement of the x-ray source relative to the first column, wherein prior to image acquisition, the positioning system is configured to move the x-ray source to an initial height determined based on the detector height, and during image acquisition, the positioning system is configured to move the x-ray source to a plurality of positions along a trajectory defined by an upper angular position, a home position, and a lower angular position.

Abstract: Disclosed herein are methods of manufacturing an oral appliance, the method comprising the steps of: a) importing into a computer aided design (CAD) computer program a digitized data set obtained from a three-dimensional scan of a patient's dentition; b) preparing a three-dimensional electronic model of the patient's dentition; c) subtracting the three-dimensional electronic model of the patient's dentition from an image of a solid block to obtain an appliance data set; and d) manufacturing a dental appliance in accordance with the appliance data set. Also disclosed are devices made by the above method, and methods of treating a condition, for example a sleep breathing disorder, by using a device made by the above method.