Abstract: Methods and apparatus for acquiring a noninvasive multi-dimensional photoplethysmogram (PPG) are provided. The apparatus comprises a plurality of light emitting diodes (LEDs), wherein a first LED of the plurality of LEDs is a first member of the group consisting of a green LED, a red LED, and an infrared LED and a second LED of the plurality of LEDs is a second member of a group consisting of a green LED, a red LED, and an infrared LED, wherein the plurality of LEDs are configured to illuminate a tissue, at least one sensor configured to sense light reflected from the tissue in response to illumination of the tissue by the plurality of LEDs, and at least one processor programmed to determine a multi-dimensional photoplethysmogram based, at least in part, on the sensed reflected light.

Abstract: Angiopoietin-like protein (ANGPTL)3/8 complexes and antibodies are disclosed, where the antibodies bind to and thereby neutralize ANGPTL3/8 complexes. Pharmaceutical compositions also are disclosed that include one or more anti-ANGPTL3/8 complex antibodies herein in a pharmaceutically acceptable carrier. Methods of making and using the same also are disclosed, especially for increase lipoprotein lipase activity and lowering triglycerides. In this manner, the compounds and compositions may be used in treating lipid metabolism-related and glucose metabolism-related diseases and disorders.

Abstract: A probe including a first sensor having a first magnetometer and a first accelerometer and a second sensor having a second magnetometer and a second accelerometer is configured for determining the distance and direction to a marker. The marker may be magnetic and may be surgically inserted into a patient's body to mark a specific location. The probe may be used to locate the marker, thus identifying the location. The probe may include a microprocessor that receives an output from the first sensor and an output from the second sensor and determines the distance and direction to the marker.

Abstract: A system for monitoring at least one biological tissue of a patient during a period of at least 24 hours. The system comprises an implantable intrabody probe and an extrabody probe which propagate an electromagnetic (EM) signal, using an antenna, via at least one tissue therebetween, in a plurality of sessions during a period of at least 24 hours, a processing unit which analyses the EM signal to detect a change in at least one biological parameter of the at least one tissue, and an output unit which outputs the change.

Abstract: A catheter is responsive to external and internal magnetic field generators for generating position data of the catheter position and pressure data to determine pressured exerted on a distal end of the catheter when engaged with tissue, with a reduced number of sensing coils and reduced number of sensing coil leads for minimizing lead breakage and failure. The catheter includes a distal section adapted for engagement with patient tissue, where the distal section has a proximal portion, a distal portion and a flexible joint with a resilient member adapted to allow axial displacement and angular deflection between the proximal and distal portions of the distal section. The catheter may have three or less sensing coils with three or less leads, each transmitting signals between a respective sensing coil and the signal processor.

Abstract: There is provided a method that includes receiving pulse oximetry measurements (SpO2) of a patient's peripheral arterial blood oxygen saturation during a first time period, and receiving breathing samples of the patient. The method further includes determining, using breathing samples of the patient, oxygen partial pressure measurements (PAO2,) and carbon dioxide partial pressure measurements (PACO2) from exhaled air of the patient during a steady-state breathing of the patient during the first time period.

Abstract: Determining lung capacity of includes capturing an audio waveform of the user performing an utterance presented to a user. A video of the user performing the utterance can be captured. The captured audio waveform and the video are analyzed for compliance. Based on the audio waveform, an indicator of respiratory function is determined. The indicator is compared with a reference indicator to determine health of the user. A machine learning model such as neural network can be trained to predict the indicator of the respiratory function based on input features comprising audio spectral and temporal characteristics of utterances. Determining the indicator or respiratory function can include running the trained machine learning model.

Abstract: Embodiments relate to a system and method for calibrating a ratio of body size of a subject including setting a body coordinate system of each body segment of the subject, calculating a first rotation matrix from a world coordinate system set based on the ground to a sensor coordinate system of each motion sensor when the subject takes a first basic pose, calculating a second rotation matrix from the world coordinate system to the sensor coordinate system of each motion sensor when the subject takes a second basic pose, calculating a third rotation matrix from the world coordinate system to the body coordinate system of a trunk for a first motion sensor attached to the trunk of the subject, and calculating a ratio of body size of the subject based on the third rotation matrix.

Abstract: An apparatus for residual limb volume management. Specifically the present invention relates to tapered prosthetic socks used in combination with a measuring template such that, when compressed, a user can see whether or not their residual limb has swelled or shrunk. The point at which the top edge of the socket of the prosthetic stops when in a compressed stance is the “0” mark on the measuring template and any upward or downward movement will be noticed by the user via a baseline drawn onto the prosthetic sock made using the measuring template. A mobile/online application can be implemented to remind the user to regularly check the baseline and instruct the user if corrective action is needed.

Abstract: A method and system for detecting a person falling, confirming a potential fall, and taking action to mitigate the effect.

Abstract: A computer-implemented method includes obtaining movement data associated with a subject and measured by a stationary motion sensor. The movement data includes a series of values representing a series of movement events of the subject crossing fields of view of the stationary motion sensor. Each movement event in the series of movement events is associated with a respective time stamp. The computer-implemented method further includes extracting a plurality of features from the movement data, determining that the movement data is consistent with symptoms of an illness using a machine-learning model and based upon the plurality of features, and generating an output indicating a result of the determination.

Abstract: Methods, systems, and devices for providing guidance during rest and recovery are described. A method may include receiving physiological data associated with a user from a wearable device. The method may include providing, to a user device associated with the user, a first set of physical activity targets and a first set of activity messages based on the received physiological data, where the first set of physical activity targets and the first set of activity messages associated with a first operational mode associated with the user. The method may include identifying a trigger to transition from the first operational mode to a second operational mode associated with the user.

Abstract: A monitoring or tracking system may include an input port and a controller in communication with the input port. The input port may receive data from a data recorder. The data recorder is optionally part of the monitoring system and in some cases includes at least part of the controller. The controller may be configured to receive data via the input port, the data being related to a subject lifting an object. Using the data, the controller may locate body parts of the subject while the subject is lifting the object and monitor body movements of the subject during the lift. Further, the controller may be configured to determine a value related to a load of the object based on the body movements monitored. The controller may output via the output port the value determined and/or lift assessment information for the subject.

Abstract: A non-contact signal detection system for detecting movement associated with a subject. A carrier source is configured to generate a first carrier signal in phase coherence with a second carrier signal. A phase-locked loop includes noise pre-cancellation system for suppressing the noise associated with a beat signal and a controlled oscillation system. The noise pre-cancellation system can be configured to phase-lock the beat signal to a first reference signal in order to stabilize the phase of the beat signal and pre-cancel the noise associated with the beat signal. The controlled oscillation system can include a propagation pathway on which a transmission signal is phase-modulated with a vibratory signal of the subject. Once acquired, the vibratory signal can have suppressed noise.

Abstract: An electrochemical physiological sensor configured to come into contact with the body fluid and including an absorber of a body fluid defining a first surface configured to at least come into contact with the body fluid and a second surface opposite to the first surface; and a circuit deposited on the second surface and configured to contact the body fluid when absorbed by the absorber; the absorber has a porosity substantially between 40% and 70% so that the body fluid is absorbed by the absorber and the circuit is deposited without penetrating the absorber.

Abstract: Analyte monitoring systems, devices, and methods associated with analyte monitoring devices, and devices incorporating the same are provided. Various graphical user interfaces (GUI) and navigation flows are provided for performing various features, activities, functions, etc., associated with the analyte monitoring device or system. Intuitive navigation is provided to enhance the interpretation of analyte measurements.

Abstract: In one aspect, an apparatus for monitoring a physiological condition of a patient is disclosed. The apparatus includes a body having an attachment portion configured to be inserted into the skin of a patient to affix the body to the patient. The apparatus includes a sensor coupled to the body that is configured to generate sensor data corresponding to a physiological condition of the patient when the body is secured to the skin of the patient. The apparatus further includes a reference sensor that is remote from the sensor coupled to the body and is configured to engage an outer surface of skin to generate reference data against which the sensor data is compared.

Abstract: Method and apparatus for optimizing analyte sensor calibration including receiving a current blood glucose measurement, retrieving a time information for an upcoming scheduled calibration event for calibrating an analyte sensor, determining temporal proximity between the current blood glucose measurement and the retrieved time information for the upcoming calibration event, initiating a calibration routine to calibrate the analyte sensor when the determined temporal proximity is within a predetermined time period, and overriding the upcoming scheduled calibration event using the current blood glucose measurement are provided.

Abstract: An insertion needle structure includes a needle sharp and a needle body. The needle body is integrally connected to the needle sharp and has a receiving space for receiving a biosensor. The needle body includes a base wall, two side walls and two slope sections. The side wall has a first inner edge and a first outer edge. The first inner edge is near the receiving space, and the first outer edge faces away from the receiving space. The slope section is connected between the side wall and the needle sharp. The slope section has a second inner edge connected to the first inner edge, and a second outer edge connected to the first outer edge. The first inner edge, the second inner edge, the first outer edge and the second outer edge are curved. A condition of R11>R12 is satisfied.

Abstract: Systems and methods for a self-powered wireless wearable sensor system include a freestanding triboelectric nanogenerator (FTENG), used as a power source for a wearable sensor. The FTENG includes stator panels and corresponding slider panels with a grating pattern. Movement, such as cardiovascular exercise causes the slider panel(s) to slide across the stator panel(s) inducing a charge and powering a wearable device sufficiently to support data transmission and continuous monitoring. An integrated self-powered wireless wearable sensor system includes a microfluidic sweat sensor patch which may be connected to lower-power wireless sensor circuitry for regulating power efficiently and is powered by the FTENG.

Abstract: A first holding member and a second holding member are arranged so as to sandwich a measurement site of a measurement subject, and are capable of clamping the measurement site. A light beam emitted from a light emitting unit is guided to the first holding member by an optical fiber, passes through an optical system, is reflected by a reflection unit, and is then incident on the measurement site. A detection unit housed in the second holding member detects a photoacoustic signal generated in the measurement site irradiated with the light beam emitted from the light emitting unit. A matching member is arranged between the second holding member and the measurement site, and is in contact with the measurement site.

Abstract: Provided is a method of determining a concentration (Ca) of a first analyte (a) in sweat excreted by a first sweat gland type at a first skin location (i) having the first sweat gland type and a second sweat gland type. The method comprises measuring a first concentration (I) of the first analyte in sweat excreted at the first skin location and measuring at least one parameter of sweat excreted by the second sweat gland type at a second skin location (ii) having the second sweat gland type but not the first sweat gland type. The at least one parameter is used to determine a dilution factor (II) which quantifies dilution of the first analyte by sweat excreted by the second sweat gland type at the first skin location. This dilution factor (II) is then used to correct the first concentration (I) so as to determine the concentration (Ca). Further provided is an apparatus (100) for determining the concentration (Ca).

Abstract: It is provided an arrangement and method for supporting a measurement of a liquid sample contained in a container, the arrangement comprising: a measurement support equipment; a camera system adapted to acquire images of a region of interest in which the container is arrangeable; and a processor adapted: to analyze at least one image of the images, in order to obtain an analysis result; and to control the measurement support equipment based on the analysis result, wherein the measurement support equipment is in particular controlled without requiring touching anything except the container.

Abstract: Various examples are described for needle alignment for wearable biosensors. One example device includes a housing comprising an upper portion and a lower portion, the housing defining a cavity between the upper portion and the lower portion and configured to be worn on a wearer's skin, wherein: the upper portion defines a first opening extending through the upper portion to the cavity, and the lower portion defines a second opening extending through the lower portion to the cavity, the cavity establishing a substantially unobstructed pathway including the first opening and the second opening to enable an insertion needle to be inserted through the housing; and a needle guide extending into and along a portion of the pathway and aligned with a sensor wire to enable alignment between the insertion needle and the sensor wire.

Abstract: An apparatus for insertion of a medical device in the skin of a subject is provided.

Abstract: An IV catheter device can include or being configured to employ a probe assembly having an integrated fluid flushing mechanism. The probe assembly can be configured in a variety of ways to cause flushing fluid to be injected through a fluid permeable structure of the probe as the probe is advanced distally from a catheter. In this way, the fluid permeable structure can be kept clear of any occlusion that may otherwise form. With the probe extending distally from the catheter, a blood sample may be collected.

Abstract: A blood collection device may include a syringe with hemolysis protection. The syringe with hemolysis protection may be coupled to a catheter assembly and used for blood draw. The blood collection device may include the syringe, which may include a distal end, and a flow restrictor. The flow restrictor may include a distal end and a proximal end. The proximal end of the flow restrictor may be coupled to the distal end of the syringe, which may protect against hemolysis.

Abstract: A method and system are provided for dynamic user interaction. The method includes assessing input data, received from a user, that is used to determine a psychological state of the user. The method further includes determining a current psychological state of the user, using an application stored in non-transitory storage media, based on the input data, and determining possible courses of action for the user based on the determined current psychological state of the user. The method additionally includes presenting the current psychological state and the possible courses of action to the user through a physical interface.

Abstract: The provided systems, methods and devices describe lightweight, wireless tissue monitoring devices that are capable of establishing conformal contact due to the flexibility or bendability of the device. The described systems and devices are useful, for example, for skin-mounted intraoperative monitoring of nerve-muscle activity. The present systems and methods are versatile and may be used for a variety of tissues (e.g. skin, organs, muscles, nerves, etc.) to measure a variety of different parameters (e.g. electric signals, electric potentials, electromyography, movement, vibration, acoustic signals, response to various stimuli, etc.).

Abstract: Manufacturing a neural interface device. Forming a neural interface probe of an implantable microelectrode body. PECVD a first amorphous silicon carbide insulation layer, forming a thin film metal trace and interface pad on the first layer, the pad on a portion of the trace. PECVD a second amorphous silicon carbide insulation layer on the first layer and covering the trace and the pad. Forming an opening in the second layer to expose the pad to an ambient environment. Patterning the first and second layers to define the neural interface probe. The probe has a rectangular cuboid shape, a cross-sectional area perpendicularly transverse to a long axis length of the probe and through any perpendicularly transverse cross-section along the long axis length is less than about 50 microns. The layers are the principle material of construction of the probe.

Abstract: A bio-electrode composition contains (A) a composite of an ionic polymer material and particles. The component (A) contains the particles bonding to the polymer containing a repeating unit having a structure selected from the group consisting of salts of ammonium, lithium, sodium, potassium, and silver formed with any of fluorosulfonic acid, fluorosulfonimide, and N-carbonyl-fluorosulfonamide. Thus, the present invention provides: a bio-electrode composition capable of forming a living body contact layer for a bio-electrode which is excellent in electric conductivity and biocompatibility, light-weight, and manufacturable at low cost, and which prevents significant reduction in the electric conductivity even when wetted with water or dried; a bio-electrode including a living body contact layer formed of the bio-electrode composition; and a method for manufacturing the bio-electrode.

Abstract: A microelectrode probe for implantation into soft tissue comprises an envelope of flexible polymer material divided by a wall into a distal and a proximal compartment filled with matrices of biocompatible material dissolvable or degradable in aqueous body fluid and comprising a centrally disposed electrically conducting core penetrating the wall and attached to it. The core is insulated at its proximal portion from which it extends to a holder for attachment to a tissue different from said soft tissue. The envelope and the core extending distally from the holder are embedded in an additional matrix of similar kind. Also disclosed is method for its manufacture, an array comprising two or more microelectrode probes and a microelectrode probe for incorporation into the array as well as method for the manufacture of the array.

Abstract: A flexible implantable electrode arrangement includes an electrically insulating carrier structure of a first polymer material, an electrically conductive layer, and an electrically insulating cover layer of a second polymer material. The electrically conductive layer includes an electrically conductive carbon fiber layer. The electrically conductive layer integrally forms an implantable electrode, a conductor track connected to the implantable electrode, and a contact pad. The electrically insulating cover layer at least partially covers the electrically conductive layer.

Abstract: A bio-electrode composition contains: (A) a polymer compound containing a repeating unit-a having a structure selected from the group consisting of salts of ammonium, sodium, potassium, and silver formed with any of fluorosulfonic acid, fluorosulfonimide, and N-carbonyl-fluorosulfonamide; and (B) a silicone compound having a polyglycerin structure. This bio-electrode composition is able to form a living body contact layer for a bio-electrode which enable quick signal collection after attachment to skin.

Abstract: The present invention relates to a method for calibrating on-line a direct neural interface implementing a REW-NPLS regression between an output calibration tensor and an input calibration tensor. The REW-NPLS regression comprises a PARAFAC iterative decomposition of the cross covariance tensor between the input calibration tensor and the output calibration tensor, each PARAFAC iteration comprising a sequence of M elementary steps (2401, 2401, . . . 240M) of minimisation of a metric according to the alternating least squares method, each elementary minimisation step relating to a projector and considering the others as constant, said metric comprising a penalisation term that is a function of the norm of this projector, the elements of this projector not being subjected to a penalisation during a PARAFAC iteration f not being penalisable during following PARAFAC iterations. Said calibration method makes it possible to obtain a predictive model of which the non-zero coefficients are sparse blockwise.

Abstract: A system for deploying an electrode array at a target location through a hole formed in the patient's cranium. The system includes an array of electrodes attached to a substrate and an inserter attached to the substrate and/or the array of electrodes. The inserter, substrate and array of electrodes are configured into a first compressed state and are positioned within the lumen of a cannula. Using the cannula, the system is inserted through the hole, the cannula is then removed, and the inserter is used to transition the substrate and electrode array from the first compressed state to a second uncompressed state, thereby deploying the array of electrodes at the target location.

Abstract: A flexible, artificial membrane circuit comprised of controlled electromagnetic coils placed in contact with the surface of tissue-capable-of-generating-an-action-potential for measurement and stimulation of activity in discrete regions of tissue. Circuit includes control systems, power systems and wireless communication systems as well to allow coil stimulation activity to be controlled by an outside source and to relay measurements of activity to an outside device.

Abstract: An electrode device for electrophysiological measurement may include an electrode substrate having a surface area. The electrode device may include a central electrode disposed on the electrode substrate around a central portion of the surface area. The electrode device may include a plurality of electrodes disposed on the electrode substrate concentric with the central electrode. The plurality of electrodes may include a first electrode covering a first portion of the surface area of the electrode substrate and a second electrode covering a second portion of the surface area of the electrode substrate. The second portion may be greater than a combined surface area of the first portion and the central portion.

Abstract: Apparatus and methods remove a voltage offset from an electrical signal, specifically a biomedical signal. A signal is received at a first operational amplifier and is amplified by a gain. An amplitude of the signal is monitored, by a first pair of diode stages coupled to an output of the first operational amplifier, for the voltage offset. The amplitude of the signal is then attenuated by the first pair of diode stages and a plurality of timing banks. The attenuating includes limiting charging, by the first pair of diode stages, of the plurality of timing banks and setting a time constant based on the charging. The attenuating removes the voltage offset persisting at a threshold for a duration of at least the time constant. Saturation of the signal is limited to a saturation recovery time while the saturated signal is gradually pulled into monitoring range over the saturation recovery time.

Abstract: A method and body-worn monitoring system for continuous fiducial point determination in SCG and ECG signals.

Abstract: A method for extracting f wave from a single-lead electrocardiography signal is provided. The method includes: establishing a two-channel temporal convolutional neural network model, including two coding submodules, two mask estimation submodules, an information fusion module and two decoding submodules; constructing a training data set of ECG signals; training the two-channel temporal convolutional neural network model, and saving the trained model. The two-channel temporal convolution neural network encodes and decodes a QRST complex and the f wave respectively, and uses a mask of information fusion to estimate and construct regular items to restrict a distribution difference of QRST component coding features, so as to reduce the distortion of the QRST complex, select potential features of a QRST complex and f wave with high signal-to-noise ratio, and thus improve a detection accuracy of the f wave.

Abstract: A guiding sheath has a hemostatic valve and a central lumen into which a diagnostic or treatment catheter can be introduced and guided into a patient. The hemostatic valve also includes an electrically conducting element or proximity sensing element on its proximal end that interacts with a second electrically conducting element or proximity sensing element on a proximal end of the diagnostic or treatment catheter that can be passed through the central lumen of the guiding sheath and into the patient's heart. The interaction between the two electrically conducting elements or proximity sensing elements enables the location of the distal end of the diagnostic or treatment catheter in the patient's heart without the need for irradiating the patient.

Abstract: Methods and apparatus are described for synchronizing a stimulus with EEG data for research and clinical and consumer applications using EEG and ECG devices. An input/output adapter for stimulus timing includes an adapter input port for receiving an encoded audio file played from an audio output device. The audio file has a first channel carrying trigger data and a second channel carrying stimulus data. The adapter is configured to separate the encoded audio file into its first and second channels; read the trigger data in the first channel and generate a trigger signal for delivery to an EEG data logger; and read the stimulus data in the second channel and generate an auditory signal for delivery to an audio playback device. Timing errors in regard to stimulus onsets are addressed by the synchronized transmission of the trigger signal and auditory signal.

Abstract: An apparatus for intraoperative neuromonitoring of nerves in the pelvic region of a patient, having at least one nerve stimulator which can be introduced into the operating area during an operation, and a sensor device which can be attached to at least one pelvic organ of the patient. In order to provide an apparatus of this type, by means of which it is possible to reliably monitor, without a significant delay, the integrity/proper functioning of nerves which act on one or more pelvic organs, i.e. in particular the bladder and/or the rectum, during an operation in the pelvic region of a patient, the sensor device includes at least two sensing electrodes, which can be applied to the pelvic organs, and an impedance measuring device, which is or can be connected to the sensing electrodes and has a display showing impedance changes in the pelvic organs between the sensing electrodes.

Abstract: Methods for assessing steatosis and fibrosis in a patient's liver include (i) measuring a diffusion-weighted relaxometry signal of the liver, or portion thereof; and determining a fibrosis content of the liver or portion thereof based on the measured diffusion-weighted relaxometry signal, or (ii) measuring a relaxometry signal of the liver, or portion thereof; and determining a fat content of the liver or portion thereof based on the measured relaxometry signal. A system for such non-invasive sensing includes a static magnetic field source; RF transmitter coils connected to a pulse sequence generator; RF receiver coils configured to detect a magnetic field generated within liver tissues; and a signal acquisition and processor system configured to acquire signals from the RF receiver coils and perform a relaxation time (T2) relaxometry measurement, wherein the RF transmitter coils and pulse sequence generator are configured to apply a varying magnetic field to the liver tissues.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium for skin health monitoring including instructions that, when executed, cause the one or more processors to perform various operations. The operations include obtaining first scan data representing a first hyperspectral scan of a user's skin at a first time. The operations include obtaining second scan data representing one or more previous hyperspectral scans of the user's skin during a period of time prior the first time. The operations include determining, based on providing the first scan data and the second scan data as input features to a machine learning model, a likelihood that the user will develop a predicted skin condition in the future. The operations include providing, for display on a user computing device associated with the user, information about the predicted skin condition.

Abstract: A system for guiding sleep restriction therapy is based on sleep data as well as medication data for a subject for a plurality of nightly sleep sessions. The sleep data and the medication data are processed to derive a target in-bed duration and to derive a target medication dose. A sleep restriction and medication recommendation are then output based on the target in-bed duration and the target medication dose. This system implements an improved sleep restriction therapy method that not only promotes the usual gradual increase of the allowed sleeping window, but also enables implementation of a gradual decrease of sleeping medication, which is beneficial for therapy adherence.

Abstract: Disclosed are biofeedback methods and devices suitable for providing biofeedback useful for helping a user control an own breathing, for example, to help in inducing deep breathing, and such biofeedback devices further comprising a dispenser for dispensing an inflatable substance.

Abstract: A dosage regimen supporting apparatus according to an embodiment includes processing circuitry. The processing circuitry estimates the symptom of the side effect of a patient as a dosage target of a therapeutic agent and the timing of onset of the symptom in the next dosage period of the therapeutic agent based on biological information or report information of the patient related to the symptom of the side effect and the timing of onset of the symptom, and attribute information of the patient. The processing circuitry outputs a suggestion related to content and a timing of treatment for dealing with the side effect based on the biological information or the report information, and an estimation result.

Abstract: A method for classifying an ostomy condition is disclosed, the method comprising obtaining image data; determining one or more ostomy representations including a first ostomy parameter based on the image data; and outputting the first ostomy parameter, wherein the method comprises transforming the image data, and wherein determining the one or more ostomy representations based on the image data comprises determining the first ostomy parameter based on the transformed image data.