Abstract: An apparatus includes an inlet configured to be placed in fluid communication with a bodily fluid source and an outlet configured to be placed in fluid communication with a fluid collection device. A sequestration portion can be configured to receive an initial volume of bodily fluid. A flow controller disposed in the sequestration portion can be configured to transition from a first state to a second state in response to contact with the initial volume of bodily fluid. As the flow controller transitions, a negative pressure differential can be defined that is operable to draw the initial volume of bodily fluid into the sequestration portion. When the flow controller is in the second state, the negative pressure differential can be substantially equalized such that (1) the sequestration portion sequesters the initial volume and (2) a subsequent volume of bodily fluid can be transferred from the inlet to the outlet.

Abstract: A fluid control device includes an inlet configured to be placed in fluid communication with a bodily fluid source and an outlet configured to be placed in fluid communication with a fluid collection device, which can produce a negative pressure differential between the outlet and the inlet. A sequestration portion is in fluid communication with the inlet and includes a first flow controller configured to transition from a first state to a second state to place the sequestration portion in fluid communication with the outlet when the negative pressure differential has a first magnitude. A sampling portion is in fluid communication with an outlet and includes a second flow controller configured to transition from a first state to a second state to place the sampling portion in fluid communication with the inlet when the negative pressure differential has a second magnitude greater than the first magnitude.

Abstract: A fluid control device includes an inlet configured to be placed in fluid communication with a bodily fluid source and an outlet configured to be placed in fluid communication with a fluid collection device, which can produce a negative pressure differential between the outlet and the inlet. A sequestration portion is in fluid communication with the inlet and includes a first flow controller configured to transition from a first state to a second state to place the sequestration portion in fluid communication with the outlet when the negative pressure differential has a first magnitude. A sampling portion is in fluid communication with an outlet and includes a second flow controller configured to transition from a first state to a second state to place the sampling portion in fluid communication with the inlet when the negative pressure differential has a second magnitude greater than the first magnitude.

Abstract: An exemplary embodiment of the present disclosure provides a method of determining stress levels in a user comprising: receiving galvanic skin response (GSR) measurements by a wearable sensor on the user over a period of time; receiving temperature measurements by the wearable sensor on the user over the period of time; determining changes in the temperature over a predetermined threshold in the temperature measurements over the period of time; calibrating the GSR measurements based on the determined changes in temperature over the predetermined threshold; calculating a stress level of the user based on the calibrated GSR measurements; and generating an output indicative of the calculated stress level.

Abstract: The purpose of the present invention is to provide a biological information measurement garment that reduces the wear discomfort. The garment includes a clothing fabric; and an electrode formed on a skin-side surface of the clothing fabric, the clothing fabric having, in the skin-side surface thereof, an area of 30 cm2 or more that is not covered with the electrode and is exposed, the electrode including a conductive member, and a heat capacity A (J/K) of the conductive member and a heat capacity B (J/K) of the clothing fabric satisfying a following formula (1).

Abstract: The novel flexible electrodes disclosed herein utilize the low bending stiffness of electrospun nanofiber mats to achieve the material properties required for surgical implantation and sustained bidirectional communication with peripheral nerves without compromising electronic functionality. According to certain embodiments disclosed herein, implantable neural electrode probes are provided which comprise a polymeric substrate having proximal and distal ends, an electrode interface at the proximal end of the substrate; at least one neural contact at the distal end of the substrate; and electrically conductive traces formed on the fibrous substrate providing electrical communication between the at least one neural contact and the electrode interface, wherein the substrate comprises a nonwoven mass of polymeric nanofibers.

Abstract: A method of heart failure prediction comprising obtaining a raw electrocardiogram (ECG) signal by a sensor, generating a clean ECG signal according to the raw ECG signal by a pre-processing circuit, performing, by a feature extraction circuit, a principal component decomposition and a heart rate feature analysis according to the clean ECG signal to generate a feature vector with a plurality of features, and generating a prediction to indicate whether the heart failure will happen in a specified period according to the feature vector by a predicting model circuit.

Abstract: A physiological information measurement device includes: a risk level determination unit configured to analyze an electrocardiographic waveform measured by a measurement unit and to determine an occurrence risk of arrhythmia in a plurality of levels; and an arrhythmia monitoring unit configured to monitor the arrhythmia, in accordance with a level of the occurrence risk of the arrhythmia determined by the risk level determination unit.

Abstract: Body-worn systems and methods for continuously monitoring a patient for cardiac electrical signals and identifying rhythm abnormalities including atrial fibrillation.

Abstract: Compositions and methods are provided for the detection and/or diagnosis of traumatic brain injury.

Abstract: Neural activity in the brain arising from a stimulus is monitored. A stimulus is applied to a target structure of the brain and a neural measurement is obtained from at least one electrode implanted in contact with the target structure. The neural measurement is configured to capture a measure of any late response arising in the target structure, typically being a neural response arising after conclusion of an ECAP, such as in the period 1.5-10 ms after stimulus onset. The late response(s) can be a useful biomarker such as of therapeutic ranges of deep brain stimulation, disease progression, medication efficacy, and intra-operative changes.

Abstract: A neural stimulus comprises at least three stimulus components, each comprising at least one of a temporal stimulus phase and a spatial stimulus pole. A first stimulus component delivers a first charge which is unequal to a third charge delivered by a third stimulus component, and the first charge and third charge are selected so as to give rise to reduced artefact at recording electrodes. In turn this may be exploited to independently control a correlation delay of a vector detector and an artefact vector to be non-parallel or orthogonal.

Abstract: A brain navigation device, comprising: a lead with an elongated lead body; at least one macro-electrode contact positioned on an outer surface on the lead; wherein the at least one macro-electrode contact is located at the distal part of said lead; and wherein the at least one macro-electrode contact is configured to be used during lead navigation.

Abstract: A system for the administration of oculomotor tests with a mobile device is disclosed. The system includes: a cradle having a cavity configured to receive the mobile device therein; at least one light and at least one light sensor arranged on the cradle; an elongated light bar attachable to and electrically connectable to the cradle; and a stand including: an elongated frame configured to rest flat on a horizontal surface, the elongated frame comprising a first end, a second end, and a long axis defined between the first and second ends; a chin rest arranged at the first end; and a cradle support arranged at the second end and supporting the cradle thereon. The system facilitates the self-administration of a full stack of oculomotor tests.

Abstract: A biological classification device and a method for Alzheimer's disease using a brain image are disclosed. The biological classification device includes an image receiving unit which receives a plurality of images obtained by capturing images of a brain of a subject; an image processing unit which acquires neurodegeneration feature related to the brain of the subject and standardized uptake value ratio (SUVR) information from the plurality of images; an image analysis unit which performs first determination of a presence or absence of cranial nerve abnormality based on the neurodegeneration feature(s) and second determination and third determination of a presence or absence of abnormality of beta amyloid protein and tau protein, respectively, based on the SUVR information; and a classifying unit which performs biological classification of the subject related to Alzheimer's disease using the first, the second, and the third determinations together.

Abstract: An explainable artificial intelligence system includes a processor that visualizes and provides a diagnosed result, a decision-making structure which is description information for describing a basis for the diagnosis, a description of at least one second brain wave feature, and an importance of the at least one second brain wave feature.

Abstract: A computer implemented and automated method for detecting and measuring an allergic reaction is described. The method utilizes a server computer, an infrared module, a camera, and electronic devices connected through a network to measure allergic reactions as well as manage a patient's end-to-end allergic treatment. The infrared (IR) module includes a temperature sensor to detect and read radiation and provide a temperature reading emitted from the wheal formed on patient's body in response to an allergen. The camera captures an image of the wheal and provides its dimensions. IR module and camera correlate data to verify accuracy and provide criticality of the reaction. The method also provides other modules such as vaccination module, scoring module, allergen recommendation module, and a skin test result management module. All modules are provided on an electronic device and allow user input and changes to manage allergy treatment.

Abstract: The present invention is directed to a method for inducing an immune response in a subject, including a step of activating neurons in the mesolimbic network of the subject by applying a neurofeedback.

Abstract: A method for recognizing physiological symptom and a physiological symptom sensing system are provided. After the sound signal is obtained, multiple signal segments are captured from the sound signal. Afterwards, a sound type corresponding to each signal segment is recognized. Moreover, a physiological state of a living body is determined based on a plurality of the sound type of the signal segments and combinations of a plurality of the sound types.

Abstract: A system for mapping and tracking at least one mole on a surface of a body comprises: an optical system configured to scan a surface of the body and to generate at least one image of at least a portion of the surface and including at least one primary imaging device attachable to at least one first maneuvering mechanism and a switching mechanism in mechanical communication with the at least one optical system. The switching mechanism is configured to reversibly switch the at least one optical system between generating the at least one image of a standing patient and generating the at least one image of a patient lying down.

Abstract: Techniques for patient pressure injury prevention (PPIP) include receiving, from a plurality of pressure sensors configured to be disposed in a spatial arrangement in contact with a patient, samples that indicate pressure measurements by the plurality of sensors at each of a plurality of different times. At each of the plurality of different times an angular orientation of the pressure is determined based on the samples. A change in the angular orientation of the pressure is determined at each successive time of the plurality of different times. A value of a patient movement parameter is determined based on the change in angular orientation of the pressure. A pressure injury category for the patient based on the value of the patient movement parameter is presented on a display device for a caregiver. Treatment of the patient by the caregiver is based on the pressure injury category.

Abstract: The present disclosure is directed to methods and apparatus for monitoring bone characteristics for various conditions such as osteoporosis and/or periodontitis. In various embodiments, a dental hygiene appliance (100) may include: a handle (102) adapted to be held by a user; a tool (106) secured to the handle to perform a dental hygiene-related task; emitter(s) (114A, 116, 360A) mounted on the dental hygiene appliance to emit wave(s) (252, 362) towards a mandible (250, 350) of the user; sensor(s) (114B, 116, 360B) mounted on the dental hygiene appliance to detect wave(s) (254, 364) propagating away from the mandible, wherein the detected wave(s) originate from or are caused by the emitted wave(s); and a controller (108) communicatively coupled with the emitter(s) and the sensor(s). The controller may: receive, from the sensor(s), signal(s) indicative of the detected waves; and determine, based on the signal(s), bone characteristic(s) of the user.

Abstract: An approach for a computer program to receive image data of a subject including at least a portion of a spine of the subject and a chronological age of the subject. The approach includes the computer program pre-processing the image data including at least a portion of a spine. The approach includes determining an apparent age of the spine or a portion of the spine of the subject using a trained artificial intelligence deep learning algorithm.

Abstract: This invention relates to the methods for the identification and isolation of cancer stem cells from cultured cancer cell lines. Cell line-derived cancer stem cells isolated using the present methods may be useful, for example, in assays to screen compounds for anti-cancer stem cell activity and in target discovery methods for identifying novel expressed genes and druggable targets. The invention also relates to the screening of compounds for activity against cell line-derived cancer stem cells.

Abstract: The present disclosure relates to a contactless sleep monitoring system and method for monitoring a plurality of characteristics of a subject based on vibration signals of a structure supporting the subject. The system can include a sensor that is coupled to the structure, but not in direct contact with the subject. A computing device in data communication with the sensor can obtain real-time sensor data from the sensor. The computing device can further analyze the sensor data to determine continuous and real-time measurements of characteristics of the subject where the characteristics can include a heart rate, a respiratory rate, a movement of the subject, and/or a posture of the subject. A user interface including a display of the determined measurements of the plurality of characteristics can be generated and displayed to a user.

Abstract: A multi-plane sleep monitoring endoscope includes an observation system, a data processing and outputting system, a lighting system, a display system, a circuit, a shell, and a power system. The observation system is a photographing system and includes two sets of imaging systems; distal ends of the imaging systems form observation ends, and the observation ends are not on the same horizontal plane. A positioning system can adjust a distance L between the horizontal planes where the observation ends are located and spatial states of the observation ends. The at least two sets of imaging systems can simultaneously perform observation and display on the display system. The multi-plane sleep monitoring endoscope can simultaneously monitor different planes in the sleep process of an obstructive sleep apnea/hypopnea syndrome patient, particularly suitable for simultaneously monitoring the velopharyngeal plane and the glossopharyngeal plane, and is safe and efficient in the clinical use process.

Abstract: Systems and methods for virtualized treatments in accordance with embodiments of the invention are illustrated. One embodiment includes a method for providing a virtualized treatment experience. The method includes steps for generating a treatment sequence includes a plurality of treatment elements, generating a virtualized environment for the generated treatment sequence, providing a plurality of treatment elements within the virtualized environment, and providing a set of one or more prompts for at least one treatment element of the plurality of treatment elements.

Abstract: A method of determining and administering therapies responsive to a circadian rhythm of a user including receiving an indication of a therapy to be administered to the user, identifying one or more periods during a circadian cycle during which administration of the therapy is preferred, defining a circadian administration time, receiving an indication of a normal circadian rhythm of the user. determining the position of the circadian administration time within the normal circadian rhythm of the user, defining a user circadian administration time, determining a time of day corresponding to the user circadian administration time, defining a clock administration time, and at least one of providing an indication to the user to administer the therapy at the clock administration time and administering the therapy to the user at the clock administration time.

Abstract: A smartwatch includes a non-invasive analyte sensor that is configured to non-invasively detect an analyte in a person wearing the smartwatch via spectroscopic techniques using non-optical frequencies such as in the radio or microwave frequency bands of the electromagnetic spectrum. The smartwatch can also include other functionality such as time keeping, date keeping, one or more additional sensors configured to sense one or more physiological properties of the wearer. Data generated by the analyte sensor and other data collected by the smartwatch or by a sensing device separate from the smartwatch can be analyzed to look for correlations between the analyte data and the other data. The results of the analysis can then be sent to the smartwatch to advise the user of the results.

Abstract: An electronic device, according to various example embodiments of the disclosure, may comprise: a display; a processor operatively connected to the display; a cover facing the display and comprising a light transmitting material; a flexible printed circuit board having a first side facing the cover, and a second side corresponding to the opposite side of the first side; a wireless charging coil disposed to surround the flexible printed circuit board; a first bio-signal sensing unit comprising bio-signal sensing circuitry including a light-emitting unit including light-emitting circuitry and a light-receiving unit including light-receiving circuitry mounted on the first side of the flexible printed circuit board; a second bio-signal sensing unit including an internal electrode formed inside the cover, which is a portion facing the flexible printed circuit board, and an external electrode electrically connected to the internal electrode and formed outside the cover; a contact having one end mounted on the first

Abstract: The present invention relates to an assembled, downward-pressing, multifunctional electroencephalogram (EEG) cap, at least comprising: a cap body, configured to be worn on a head of a patient, and formed by a plurality of constituent blocks, wherein each of the constituent blocks comprises a first unit and a second unit that carry extracranial electrodes for detecting EEG signals from corresponding areas of the head of the patient, in which the first unit and the second unit are configured to perform relative movements and thereby change their relative positions, the first unit and the second unit being shaped to fit a curved surface of the head of the patient; the first unit of the constituent block being movably connected to the second unit by means of a drive system provided between at least a part of the first unit and a part of the second unit, wherein the extracranial electrodes located on the first unit and on the second unit are configured to at least follow the relative movements between the first un

Abstract: An optical fiber sensing system according to the present disclosure includes clothing (10) including an optical fiber (20), an optical fiber sensing unit (31) configured to receive an optical signal from the optical fiber (20), and acquire, based on the optical signal, a plurality of parameters each having a pattern according to a state of a person wearing the clothing (10), and a state detection unit (32) configured to detect a state of a person wearing the clothing (10), based on a pattern contained in each of the plurality of parameters.

Abstract: A garment (e.g., a shirt) for monitoring biometric properties of the wearer of the garment is disclosed. The garment may include sensors for monitoring or assessing biometric properties such as, but not limited to, respiration properties, heart properties, and motion properties. These properties may be assessed together to provide an assessment of vital signs and body position (e.g., three-dimensional body position) of the wearer of the garment.

Abstract: A microsensor and method of manufacture for a microsensor, comprising an array of filaments, wherein each filament of the array of filaments comprises a substrate and a conductive layer coupled to the substrate and configured to facilitate analyte detection. Each filament of the array of filaments can further comprise an insulating layer configured to isolate regions defined by the conductive layer for analyte detection, a sensing layer coupled to the conductive layer, configured to enable transduction, and a selective coating coupled to the sensing layer, configured to facilitate detection of specific target analytes/ions. The microsensor facilitates detection of at least one analyte present in a body fluid of a user interfacing with the microsensor.

Abstract: The present disclosure concerns a device for examining a capillary area of the skin of a finger, said device comprising: an optical microscope); —a light source for illuminating the capillary area; —a support comprising a recess for receiving the finger, said recess comprising an opening positioned opposite the microscope; —the microscope being mounted to rotate on the support about a main axis of the finger so as to scan the capillary area from one edge of the finger to the other; —immobilisation means being configured to adjust the dimension of the recess relative to the shape of the finger in order to immobilise the finger in the recess without exerting pressure on the finger. The examination device of the present disclosure is particularly suitable for examining a capillary area of the skin of a finger in order to detect vascular anomalies.

Abstract: A wearable device that attaches to a body part of a user via an attachment member operates in at least a connected and a disconnected state. One or more sensors located in the wearable device and/or the attachment member detect the user's body part when present. Such detection may only be performed when the attachment member is in a connected configuration and may be used to switch the wearable device between the connected and disconnected states. In this way, the wearable device operates in the connected state when worn by a user and in the disconnected state when not worn by the user.

Abstract: A clamping device for reducing blood flow in a human limb comprises a first rigid part having a first inner profile, and a second rigid part having a second inner profile generally facing the first inner profile. A coupling portion couples the first rigid part and second rigid part to each other. The first inner profile extends further away from the coupling portion than the second inner profile. The first and second inner profiles define a recess, the recess being shaped to enable the clamping device to be positioned on the human limb, and the clamping device being configured to shift between an expanded configuration and a clamped configuration. The first and second inner profiles are arranged to apply pressure against the human limb when the device is in the clamped configuration and thereby to apply pressure to blood vessels in the human limb and reduce blood flow through the blood vessels.

Abstract: The present embodiments relate generally to applicators of on-skin sensor assemblies for measuring an analyte in a host, as well as their method of use and manufacture. In some aspects, an applicator for applying an on-skin sensor assembly to a skin of a host is provided. The applicator includes an applicator housing, a needle carrier assembly comprising an insertion element configured to insert a sensor of the on-skin sensor assembly into the skin of the host, a holder releasably coupled to the needle carrier assembly and configured to guide the on-skin sensor assembly while coupled to the needle carrier assembly, and a drive assembly configured to drive the insertion element from a proximal starting position to a distal insertion position, and from the distal insertion position to a proximal retraction position.

Abstract: The present embodiments relate generally to applicators of on-skin sensor assemblies for measuring an analyte in a host, as well as their method of use and manufacture. In some aspects, an applicator for applying an on-skin sensor assembly to a skin of a host is provided. The applicator includes an applicator housing, a needle carrier assembly comprising an insertion element configured to insert a sensor of the on-skin sensor assembly into the skin of the host, a holder releasably coupled to the needle carrier assembly and configured to guide the on-skin sensor assembly while coupled to the needle carrier assembly, and a drive assembly configured to drive the insertion element from a proximal starting position to a distal insertion position, and from the distal insertion position to a proximal retraction position.

Abstract: In an embodiment a vital sign sensor includes an emitter component configured to emit light, a detector component configured to detect light, a first layer of a substantially transparent material, wherein the emitter component is embedded in the first layer, and a second layer of a light scattering material arranged on the first layer, wherein the second layer includes converter particles, and wherein the first layer and the second layer are surrounded by at least one wall of a reflective material.

Abstract: A signal quality index evaluation circuit, comprises: a surrounding sensor; a zero-phase filter; and an evaluation circuit. The surrounding sensor senses its surrounding to generate a reference correction signal. The zero-phase filter is configured to generate a clean biological signal according to a biological signal and the reference correction signal, wherein the clean biological signal includes a plurality of period signals, and each one of the period signals has a biological value. The evaluation circuit is configured to calculate norm range according to the clean biological signal and one or more of the biological values of the period signals, and determine a difference between each one of the biological values corresponding to each one of the period signals and the norm range, the evaluation circuit is further configured to calculate and output a signal quality index according to the differences.

Abstract: In one embodiment, a method to determine reliable electrocardiogram (ECG) signal is described. The method includes receiving at least one ECG signal for a period of time from a patient. The method also includes analyzing the at least one ECG signal to determine a first heart rate using a first method and analyzing the at least one ECG signal to determine a second heart rate using a second method different from the first method. The method includes comparing the first and second heart rates to each other and classifying the at least one ECG signal as reliable when a reliability threshold is satisfied.

Abstract: Systems and methods for determining myocardium strain and intracardiac blood flow data of the heart are provided. Input medical imaging data of a heart of a patient is received. At least one of extracted myocardium strain data of the heart and extracted intracardiac blood flow data of the heart is determined from the input medical imaging data. At least one of predicted myocardium strain data of the heart and predicted intracardiac blood flow data of the heart is determined based on the at least one of the extracted myocardium strain data and the extracted intracardiac blood flow data using a model of the heart. The model of the heart jointly models myocardium strain of the heart and intracardiac blood flow of the heart. The at least one of the predicted myocardium strain of the heart and the predicted intracardiac blood flow of the heart is output.

Abstract: An artificial intelligence (AI) system is disclosed that uses machine learning to classify retinal features contained in OCTA data acquired by a data acquisition system and to predict one or more retinopathies based on the classification of retinal features. The AI system comprise a processor configured to run a classifier model comprising a machine learning algorithm and a memory device that stores the classifier model, OCTA training data and acquired OCT A data. The machine learning algorithm performs a process that trains the classifier model to classify retinal features contained in OCT A training data.

Abstract: A method and a system analyze an individual's physiological data to identify aberrant vital-signs patterns and estimate an infection probability. The identification includes determining a score based on the current vital-sign measurements, and the mean and standard deviation of baseline vital-signs values. In one embodiment, the mean and the standard deviation are selected based on the corresponding baseline time window and activity bin of the current vital-sign measurement. The score is identified as normal when between two thresholds and aberrant outside of those two thresholds.

Abstract: A method and system for acquiring data for assessment of cardiovascular disease, the method comprising one or more of: manipulating one or more hardware aspects of the photoplethysmography data acquisition system(s) implementing the method; manipulating or providing user experience/user interface (UX/UI) aspects of the system(s) implementing the method; acquiring, processing, and deriving insights population specific data; accounting for or controlling sampling site variability; and using other suitable sources of data in order to generate high quality data for characterization, assessment, and management of cardiovascular disease.

Abstract: A system for patient body imaging with live feed medical video consultation. The system includes an imaging booth with a plurality of cameras for capturing body images of a patient, a server for storing and transmitting patient images and patient information, a computer and/or mobile computing device in communication with the server, and a computer processing unit in communication with a program application that includes the ability to conduct or schedule a live feed video consultation between the patient and a medical provider where the live feed video consultation enables both the patient and the medical provider to view the patient's body images. The imaging booth may be a foldable total body imaging apparatus that includes a foldable floor to produce a compact folded apparatus having a small footprint when not in use.

Abstract: A cone-beam computed tomography (CBCT) method uses a continuous beam and an area detector to carry out fast acquisition of projection data. The acquired projection data are then reconstructed to generate tomographic images. In acquisition of the projection data, a radiation source continuously irradiates a subject with a cone beam of radiation from a plurality of angles and an area detector continuously reads out data. A CBCT system including a source operable to produce a cone beam of radiation and an area detector movable in synchrony with the source to rapidly acquire projection data for CBCT construction is also disclosed.

Abstract: A medical imaging system includes an imaging unit that obtains a medical image or data used for generating the medical image by imaging a subject, a processor that stores positioning data for specifying arrangement of the subject with respect to the imaging unit, and a display unit that three-dimensionally displays the arrangement of the subject with respect to the imaging unit by using the positioning data in a case where the subject is imaged using the imaging unit.

Abstract: A surgical table with an integrated imaging device can obtain images of a patient's body part. The surgical table can include a base, a patient support platform, at least one platform support connected to the base, and an imaging device support that is mounted on the base and an imaging device mounted on the imaging device support. The patient support platform can be at least partially positioned between a first arm and a second arm. A first radiation source can be positioned in or on the first arm and a first radiation detector can be positioned in or on the second arm, with the first radiation detector arranged to detect at least a portion of the radiation emitted by the first radiation source.