Abstract: An aseptic coupling arrangement can include a first coupling device and a second aseptic coupling device. In one embodiment, the first and second coupling devices are substantially similar, each having a main body defining a front face and a fluid passageway therethrough. A first connecting feature disposed on the main body of each coupling device may be provided for aligning and coupling the aseptic devices together. Each coupling device may also include a sealing member received in the main body and a membrane removably coupled to the main body front face to cover the sealing member. The first aseptic coupling device may also include a rotatable protective cover that is removably attached to the main body and connected to the membrane. In one embodiment, the removal of the protective covers away from two coupled main bodies, in a direction parallel to the front faces, causes removal of the membranes.

Abstract: A connector for medical fluid vessels includes a fluid-seal fitting such as a male plug defining a lumen and mating with a cooperating connector, a mechanical fastener such as a screw thread for mating with the cooperating connector, and an outer housing positioned around the plug to form an annular space. A cap can be provided with a fluid-seal fitting such as a male plug for mating with the lumen of the connector. In example embodiments, the male plug is tapered and can comprise one or more projections for sealingly engaging with the lumen of the connector. According to some example embodiments, the cap can be tethered to the connector.

Abstract: The present invention relates to a cap for a medical connector. More specifically, the present invention related to an antimicrobial cap for placement over a connector, wherein various features of the antimicrobial cap maintain the connector in an antiseptic state.

Abstract: An exemplary compounding system and method can include two pump heads for simultaneously drawing two different fluids from at least two separate input containers such that the at least two different fluids are mixed and distributed to an output container. The system can include a manifold that maintains separation of certain of the different fluids until after passing by a first pump and a second pump and/or additional pumps. A junction can be placed in the fluid line downstream of the first and second pumps and/or additional pumps such that all or some of the fluids are mixed prior to output to the output container. The method of using the system can include incorporating software that selects various fluids at certain times and sequences to ensure optimum efficiency and safety for the system, and can continue compounding actions even when an input supply container runs out or otherwise fails to supply a particular fluid/material.

Abstract: An impeller for a pump is disclosed herein. The impeller can include a hub having a fixed end and a free end. The impeller can also have a plurality of blades supported by the hub. Each blade can have a fixed end coupled to the hub and a free end. The impeller can have a stored configuration and a deployed configuration, the blades in the deployed configuration extending away from the hub, and the blades in the stored configuration being compressed against the hub.

Abstract: The systems and methods described herein determine metrics of cardiac performance via a mechanical circulatory support device and use the cardiac performance to calibrate, control and deliver mechanical circulatory support for the heart. The systems include a controller configured to operate the device, receive inputs indicative of device operating conditions and hemodynamic parameters, and determine vascular performance, including vascular resistance and compliance, and native cardiac output. The systems and methods operate by using the mechanical circulatory support device (e.g., a heart pump) to introduce controlled perturbations of the vascular system and, in response, determine heart parameters such as stroke volume, vascular resistance and compliance, left ventricular end diastolic pressure, and ultimately determine native cardiac output.

Abstract: Methods, systems, and devices for implantable node are described. The method may include storing, at an implantable stimulation node, a set of stimulation profiles in a memory during a configuration phase. The method may also include receiving a stimulation command corresponding to a stimulation profile of the set of stimulation profiles during a treatment phase. The method may further include delivering stimulation based at least in part on the stimulation profile corresponding to the received stimulation command. In some cases, the system may include an implantable hub, an implantable sensing node, and a sensing device.

Abstract: The present invention provides a biomedical electrode composition capable of forming a living body contact layer for a biomedical electrode that is excellent in conductivity and biocompatibility, is light-weight, can be manufactured at low cost, and can control significant reduction in conductivity even though the biomedical electrode is soaked in water or dried. The present invention was accomplished by a biomedical electrode composition including a polymer compound having both the ionic repeating unit “a” and the repeating unit “b” of (meth)acrylate, in which the ionic repeating unit “a” is a repeating unit of sodium salt, potassium salt, or ammonium salt including a partial structure represented by the following general formula (1), and the repeating unit “b” of (meth)acrylate is a repeating unit represented by the following general formula (2).

Abstract: A device for transport of ions and/or charged molecules between a source and a target electrolyte, comprising: a first electrode provided at or in said source electrolyte, and a second electrode provided at or in said target electrolyte; and wherein said first and second electrodes provides an electrical control of an ion flow, and further comprising means for limiting an electronic current between said source and said target electrodes, such that at least after a voltage is applied a potential difference between said source and target electrodes is maintained, which effects ion transport from said source to said target electrode; wherein the device further comprises an ion- and/or permselective polyelectrolyte for transport ions and/or charged molecules via electrophoresis and functions as an ion-selective membrane; and wherein said polyelectrolyte comprises a cross-linked hyperbranched polymer.

Abstract: Methods and systems for alleviating disorders and complications associated with autonomic nervous system dysfunction. The approach generally includes measuring heart rate signals from a subject to measure heart rate variability and determine a heart rate variability threshold, determining that the subject is experiencing autonomic nervous system dysfunction, and alerting the subject to stimulate the auricular branch of the vagus nerve with an ear device.

Abstract: A neck-hanging massaging device includes an elastic arm, a first handle, a second handle, an electrode assembly and an electric pulse generating device. The first handle and the second handle are fixedly connected to the two sides of the elastic arm. The electrode assembly is arranged on the elastic arm. The electric pulse generating device is electrically connected with the electrode assembly. The electric pulse generating device is arranged in the first handle.

Abstract: A conductive human interface includes an insulating body of elastomeric material and a compliant electrode embedded in the insulating body. The electrode is formed from an electrically conductive gel including a polymeric material and conductive particles dispersed in the polymeric material. The conductive particles can be included in the gel in an amount that is not more than about 10% by weight.

Abstract: A cylindrical microelectrode array having an elongated cylindrical core, and a multilayer structure conformally folded around and affixed to the cylindrical core so as to extend between opposite ends of the core. The multilayer structure has integrated sections including an electrode section with electrodes exposed through electrically insulating layers, a connector section with conductive bond pads for interfacing with external electronics, and a cable section with conductive traces encapsulated in electrically insulating layers and which connect between the electrodes and their corresponding bond pads. The array may be fabricated using a planar multilayer structure having the electrode, connector, and cable sections, and conformally folding the multilayer structure around and affixing to the cylindrical core. The cable section in particular may be conformally coiled around and affixed to the cylindrical core so that the electrical conduits helically extend between the connector and electrode sections.

Abstract: An extravascular neural interface is disclosed including a device containing electrodes for neurostimulation of a vessel. The devices are housed in flexible substrates forming two flaps, an inner flap having a spinal portion for routing leads/conductors into the device for connection to the electrodes and an outer flap that overlaps the inner flap. The inner flap supports and positions the electrodes to be inward facing, i.e., extravascular designs. The electrodes may be circular or elliptical and include a plurality of wings for securing the electrodes within a flap.

Abstract: A device for extending a lead according to some embodiments includes a body, a tubular member coupled to the body, the tubular member comprising an outer surface, wherein the outer surface is sized to insert into an inner lumen of a lead, the tubular member is movable between a first configuration in which the tubular member slides into the lead, and a second configuration in which at least a portion of the tubular member expands to engage an inner surface of the lead; and, an actuation mechanism operatively coupled to the tubular member, the actuation mechanism configured to move the tubular member between the first configuration and second configuration.

Abstract: Systems, devices, and methods for electroporation ablation therapy are disclosed, with the system including a pulse waveform signal generator for medical ablation therapy that may be coupled to an ablation device including at least one electrode for ablation pulse delivery to tissue. The signal generator may generate and deliver voltage pulses to the ablation device in the form of a pulse waveform in a predetermined sequence where the signal generator may independently configure a set of electrodes of an ablation device. The signal generator may further perform active monitoring of a set of electrode channels and discharge excess energy using the set of electrode channels.

Abstract: A system for stimulating body tissue may include a stimulation lead, sensors, and a control unit. The stimulation lead may include one or more energy sources. The control unit may include a processor and non-transitory computer readable medium, and an interface (e.g., touch screen interface) for receiving user inputs and communicating information to the user. The sensors may be configured to provide impedance measurements to the control unit. The control unit may calculate lung gas distributions and/or generate an image modeling lung gas distributions. Stimulation delivered by the stimulation may be adjusted based on the impedance measurements.

Abstract: Apparatus and methods are described including placing a set of two or more electrodes (22) in electrical contact with a portion of a subject's body. At least one computer processor (24) drives the electrodes to apply an amplitude shift keying signal to the portion of the subject's body, the amplitude shift keying signal containing a high frequency component that acts as a carrier wave, the high frequency component having a frequency of between 80 Hz and 120 Hz, and a low frequency component that acts as a modulating component that modulates the carrier wave, the low frequency component having a frequency of between 1 Hz and 8 Hz. Other applications are also described.

Abstract: A system for controlling blood pressure includes a wearable interface having an internal contact surface, the wearable interface configured to at least partially encircle a first portion of a first limb of a subject, a sensing module carried by the wearable interface and configured to determine at least a change in blood pressure of the first limb of the subject, and an energy application module carried by the wearable interface and configured to apply energy of two or more types to the first limb of the subject.

Abstract: At least one of the first or second hearing prostheses of a binaural hearing prosthesis system includes a dual-mode sound processing unit that is configured to selectively operate in a “sound processing mode” or in a “wireless streaming mode.” When operating in the sound processing mode, the dual-mode sound processing unit is configured to convert received sound signals into output signals for use in stimulating a first ear of a recipient. However, while operating in the wireless streaming mode, the dual-mode sound processing unit is configured to capture input signals (e.g., sound signals, data signals, etc.) and to encode those input signals for direct or indirect wireless transmission to the sound processing unit of the other hearing prosthesis of the binaural hearing system.

Abstract: Systems and methods for applying electrical stimulation to different sub-populations of targeted neurological tissue for optimizing spinal cord stimulation are disclosed. According to an aspect, a method includes applying a first pattern of electrical stimulation to a first sub-population of targeted neurological tissue of a subject. The method also includes applying a second pattern of electrical stimulation to a second sub-population of targeted neurological tissue of the subject, the second pattern of electrical stimulation being applied at a different frequency than the first pattern of electrical stimulation.

Abstract: A method of treating osteoarthritis in a knee includes generating, by an implantable stimulator configured to be implanted beneath a skin surface of a patient, stimulation sessions at a duty cycle that is less than 0.05, and applying, by the implantable stimulator in accordance with the duty cycle, the stimulation sessions to a location that includes at least one of an acupoint labeled ST35, an acupoint labeled EX-LE-4, and a location on a line that intersects the acupoints labeled ST35 and EX-LE-4. The duty cycle is a ratio of T3 to T4. Each stimulation session included in the stimulation sessions has a duration of T3 minutes and occurs at a rate of once every T4 minutes. The implantable stimulator is powered by a primary battery located within the implantable stimulator and having an internal impedance greater than 5 ohms.

Abstract: Transvascular diaphragm pacing systems (TDPS) and methods are disclosed for providing respiratory therapy to a patient. The TDPS can provide rapid insertion and deployment of endovascular pacing electrodes in critically ill patients who require intubation and invasive PPMV in order to support the physiological requirements of the human ventilatory system. The systems and methods make best use of the contractile properties of the diaphragm muscle and prevent muscle disuse and muscle atrophy. This can be carried out by engaging the phrenic nerves using patterned functional electrical stimulation applied to endovascular electrodes that are temporarily and reversibly inserted in central veins of the patient, such as the left subclavian vein and the superior vena cava.

Abstract: A system for estimating a volume of activation around an implanted electrical stimulation lead for a set of stimulation parameters includes a display; and a processor coupled to the display and configured to: receive a set of stimulation parameters including a stimulation amplitude and a selection of one of more electrodes of the implanted electrical stimulation lead for delivery of the stimulation amplitude; determine an estimate of the volume of activation based on the set of stimulation parameters using the stimulation amplitude and a database including a plurality of planar distributions of stimulation threshold values and a map relating the planar distributions to spatial locations based on the one or more electrodes of the implanted electrical stimulation lead selected for delivery of the stimulation amplitude; and output on the display a graphical representation of the estimate of the volume of activation.

Abstract: An intracardiac ventricular pacemaker having a motion sensor is configured to produce a motion signal including an atrial systolic event and a ventricular diastolic event indicating a passive ventricular filling phase, set a detection threshold to a first amplitude during an expected time interval of the ventricular diastolic event and to a second amplitude lower than the first amplitude after an expected time interval of the ventricular diastolic event. The pacemaker is configured to detect the atrial systolic event in response to the motion signal crossing the detection threshold and set an atrioventricular pacing interval in response to detecting the atrial systolic event.

Abstract: An implantable medical device performs a method that includes detecting a cardiac event interval that is greater than a P-wave oversensing threshold interval. In response to detecting the cardiac event interval greater than the P-wave oversensing threshold interval, the device determines the amplitude of the sensed cardiac signal and withholds restarting a pacing interval in response to the amplitude satisfying P-wave oversensing criteria. A pacing pulse may be generated in response to the pacing interval expiring without sensing an intrinsic cardiac electrical event that is not detected as a P-wave oversensing event.

Abstract: A pacemaker lead for cerclage pacing includes a lead fixing part including a fixing tip whose diameter becomes gradually smaller toward an end of a distal part thereof, a plurality of bipolar electrodes that come into close contact with heart muscle, in an outer circumference of the lead fixing part, and a guide wire insertion through hole through which a guide wire can be inserted thereinto, a lead body part configured to be extended to the lead fixing part, having a stylet insertion through hole formed therein, and a body fixing part formed in a bent shape so as to be fixed to an inner wall of the coronary sinus, and a stylet inserted into the stylet insertion through hole, enabling the pacemaker lead for cerclage pacing to be easily moved within the body of the patient.

Abstract: A method programs an implantable medical device to configure the implantable medical device for stimulating neural tissue by at least one electrode. The method includes: performing, by the implantable medical device, an evoked compound action potential (eCAP) threshold search by stimulating the neural tissue with test stimulation pulses; determining, based on the eCAP threshold search, an eCAP threshold amplitude and a coupling factor that is indicative of a coupling between the at least one electrode and the neural tissue; and generating a first set of stimulation parameters containing at least a stimulation amplitude that is determined in dependence on the eCAP threshold amplitude and the coupling factor.

Abstract: An electronic medical device includes a first portion, with the first portion including a first insertion hole and an external surface. The first insertion hole is to removably receive an elongate element. The external surface of the first portion comprises a first position indicator, which is located to be visibly juxtaposed relative to a first operative element of the elongate element when the elongate element is fully inserted in the first insertion hole. In some instances, the position indicator may serve a dual function as a vent.

Abstract: A connector and lead (or other elongated body) can produce a tactile sensation that indicates alignment between connector contacts of the connector and the terminals on the lead (or other elongated body). For example, a terminal or retention sleeve of the lead (or other elongated body) may include an indented circumferential groove that interacts with a connector contact or retention contact of the connector to produce the tactile sensation. As another example, one or more terminals or spacers may have a larger diameter than adjacent spacers or terminals to interact with a connector contact to produce the tactile sensation.

Abstract: A medical lead includes a lead body, an electrical connector, an electrical conductor, and a sleeve. The lead body includes a distal end and a proximal end defining a longitudinal axis of the lead body. The electrical connector is positioned near the proximal end of the lead body. The electrical conductor extends about the longitudinal axis of the lead body. The sleeve is coupled to an insulative material of the lead body and positioned around the electrical conductor. The electrical conductor is electrically coupled to the electrical connector. The sleeve is not fixed to the electrical conductor. In response to bending of the medical lead, the conductor may move within the sleeve to relieve strain created by the bending.

Abstract: An energy harvester includes a pendular unit subjected with a piezoelectric beam coupled to an inertial mass. On the clamped side of the beam, a beam frame includes two pressing elements between which the beam is taken in sandwich, each including i) an intermediate part, an internal face of which presses on a corresponding face of the beam, and ii) a pressure plate, an internal face of which presses on an external face of the intermediate part, a printed circuit board being interposed between them. The intermediate parts and the pressure plates are passed through by at least one common transverse bore receiving a locking pin. The intermediate parts, the pressure plates and the pin are each massive metal parts ensuring a direct electrical and mechanical contact with the electrodes of the beam and with the printed circuit boards.

Abstract: A system is provided for driving an implantable neurostimulator lead, the lead having an associated plurality of electrodes disposed in at least one array on the lead. The system comprises an implantable pulse generator (IPG), the IPG including an electrode driver, a load system for determining load requirements, an IPG power coupler, and an IPG communication system. The system also includes an external unit, which includes an external variable power generator, an external power coupler, an external communication system, and a controller for varying the power level of the variable power generator.

Abstract: A system and method for extra cardiac defibrillation is disclosed. In a particular embodiment, an extra cardiac implantable cardioverter defibrillator system includes an implantable defibrillator having a metal case and a defibrillation lead. The defibrillation lead has a connector at its proximal end for coupling to the implantable defibrillator and a first defibrillation coil electrode at a distal portion of the lead. The first defibrillation electrode configured to be disposed in an inferior vena cava.

Abstract: Methodologies and mechanisms are provided for introducing one or more magnetizable particles introduced non-invasively into one or more body structures containing nervous tissue in a subject, directing, guiding, transporting, focusing and/or concentrating the one or more particles using at least one image-guidance component in proximity to the one or more body structures which can direct the one or more particles within the one or more body structures, and modulating, using at least one activation component, the one or more particles to modulate neuronal function in the one or more body structures of the subject.

Abstract: A wearable ultraviolet light phototherapy device is disclosed. The wearable ultraviolet light phototherapy device can have a substrate or a housing that is to be worn on a body part of a patient. At least one ultraviolet light emitting source located about the substrate or housing can deliver ultraviolet radiation into the body part of the patient. A control module can control operation of the at least one ultraviolet light emitting source. To this extent, the control module can direct the at least one ultraviolet light emitting source to deliver a predetermined amount of ultraviolet radiation at a peak wavelength into the body part of a patient. The control module can determine the predetermined amount of ultraviolet radiation as a function of the patient's susceptibility to ultraviolet radiation.

Abstract: An aspect of the present disclosure relates to an electronic device, and more particularly, to an electronic device that may include: a substrate; a plurality of light emitting devices, disposed on the substrate; a wavelength converting layer, disposed on the substrate, wherein the plurality of the light emitting devices emit a light of same color, wherein light emitted from the light emitting devices is converted by going through the wavelength converting layer, wherein the converted light is extracted to outside of the electronic device, and has a wavelength longer than that of the light emitted from the light emitting devices. Through this, an electronic device can be provided emitting light having a wavelength from which effects of inflammation treatments and skin regeneration can be acquired.

Abstract: An apparatus is provided for ocular stimulation. In embodiments, the apparatus comprises ocular stimulator circuitry couplable with a headwear item, and a plurality of ocular stimulator LED packages electrically couplable to the ocular stimulator circuitry. The plurality of ocular stimulator LED packages are configured to stimulate a pineal gland associated with a live subject on which the headwear item is disposed. The apparatus may be configured to cause the ocular stimulator LED packages to emit light according to at least one pre-programmed operating mode.

Abstract: A device to stimulate the retina comprises one or more light sources coupled to one or more optical elements. The one or more optical elements is configured to illuminate the retina with one or more images at a location away from a fovea of a wearer. In some embodiments, each of the one or more images comprises a depth of focus and a spatial resolution. The one or more images can be formed at a distance anterior to the retina, at a distance posterior to the retina or on the retina. In some embodiments, the depth of focus is less than the distance, and the spatial resolution greater than a spatial resolution of the retina at the location.

Abstract: A method and device for treating an infection of the nail or nail bed and adjacent tissues through non-thermal means is described. The device illuminates an area with light in the near-infrared region of the electromagnetic spectrum. Preferably, light having wavelengths of from about 870 nm to about 930 nm will be used. Further, the device includes light emitting diodes that are capable of emitting ultraviolet light. These lights are intended to provide a sterile environment for a user using the device.

Abstract: Techniques for generating a radiotherapy treatment plan are provided. The techniques include receiving an input parameter related to a patient, the input parameter being of a given type; processing the input parameter with a machine learning technique to estimate a realizable plan parameter of a radiotherapy treatment plan, wherein the machine learning technique is trained to establish a relationship between the given type of input parameter and a set of realizable radiotherapy treatment plan parameters to achieve a target radiotherapy dose distribution; and generating the radiotherapy treatment plan based on the estimated realizable plan parameter.

Abstract: Systems and methods for radiation treatment planning based on a model of planning strategies knowledge including treatment states and treatment actions are disclosed. According to an aspect, a method includes receiving geometric characterization data of a target volume for radiation treatment of a patient. The method also includes receiving geometric characterization data of at least one organ at risk proximate the target volume. Further, the method includes constructing a model for applying a predetermined radiation dosage to the target volume based on the received data. The model includes treatment states and associated treatment actions selectable to implement at each state. The method includes presenting information about at least one treatment state, the treatment actions associated with the at least one treatment state, and the rewards associated with the treatment actions associated with the at least one treatment state. The method also includes reconstructing the model.

Abstract: A processing device determines a plurality of angles from which tracking images can be generated by an imaging device. The processing device generates a plurality of projections of a treatment planning image of a patient, the treatment planning image comprising a delineated target, wherein each projection of the plurality of projections has an angle that corresponds to one of the plurality of angles from which the tracking images can be taken. The processing device determines, for each angle of the plurality of angles, a value of a tracking quality metric for tracking the target based on an analysis of a projection generated at that angle. The processing device selects a subset of the plurality of angles that have a tracking quality metric value that satisfies a tracking quality metric criterion.

Abstract: Example methods and apparatuses of controlling a user interface with a plurality of input mechanisms are disclosed. One example method includes causing a first set of input mechanisms in the plurality of input mechanisms to be visually emphasized via a first visual technique while a second set of input mechanisms in the plurality of input mechanisms is not visually emphasized via the first visual technique, receiving a user input via an input mechanism that is included in the first set, based on the user input, determining a third set of input mechanisms in the plurality of input mechanisms and a fourth set of input mechanisms in the plurality of input mechanisms, and causing the third set of input mechanisms to be visually emphasized via the first visual technique while the fourth set of available input mechanisms is not visually emphasized via the first visual technique.

Abstract: Various approaches for enhancing treatment of target tissue using a source of focused ultrasound while limiting damage to non-target tissue include selecting a frequency of ultrasound waves transmitted from the source of focused ultrasound for generating a focus in the target tissue; providing microbubbles having the first size distribution such that at least 50% of the microbubbles have a radius smaller than a critical radius corresponding to a resonance frequency matching the selected frequency of ultrasound waves; and applying the ultrasound waves at the selected frequency to treat the target tissue.

Abstract: Described herein are methods for beam station delivery of radiation treatment, where the patient platform is moved to a series of discrete patient platform locations or beam stations that are determined during treatment planning, stopped at each of these locations while the radiation source rotates about the patient delivering radiation to the target regions that intersect the radiation beam path, and then moving to the next location after the prescribed dose of radiation (e.g., in accordance with a calculated fluence map) for that location has been delivered to the patient.

Abstract: Portable breathing equipment and related methods are disclosed. An example portable breathing equipment (PBE) includes a housing defining a cavity, a cover movably coupled to the housing, and a smoke hood provided in a wrapper and positioned in the cavity. A first portion of the wrapper couples to the housing and a second portion of the wrapper couples to the cover. At least one of the cover or the housing to cause the wrapper to tear to provide an access opening to allow access to the smoke hood when the cover moves from a closed position at which the cover seals the cavity of the housing and an open position at which the cover enables access to the cavity of the housing.

Abstract: There is provided a mask clip assembly for use with a face mask. The assembly includes a housing having inner and outer housing shells. The housing has open and closed positions. In the closed position the inner and outer housing shells are engaged with each other and form a cavity between the inner and outer housing shells. In the open position the inner and outer housing shells are separated and disposed away from each other in comparison to the closed position, the housing being sized and configured to engage the face mask with a portion of a mask periphery disposed in the cavity with the housing in the closed position. The assembly includes an air filter and intake and exhaust ports. The assembly includes an intake tube attached to the housing and in fluid communication between the housing and the intake port. The intake tube is positionable adjacent an inner face mask side with the housing in the closed position with a portion of the mask periphery disposed in the cavity.

Abstract: In a contaminated environment with health threatening aerosol a helmet with transparent face shield as an alternative to mask can be used. The helmet protects the entire head of a person using a transparent shield that is knotted at the back of the neck. The helmet uses a fan to suck the environment air, filter it with an aerosol filter and releases the clean air into the interior of the helmet. The contaminated air inside the helmet is filtered and then the clean air is sucked by another fan and released to the environment. The fans are battery powered and their speed can be controlled using sensors and a controller.

Abstract: A diaphragm or non-return valve is disposed in a supporting wall and includes a diaphragm plug and a valve seat having a passage opening surrounded by a continuous surface for sealing adhesion contact of a sealing lip of the diaphragm plug. The diaphragm plug is made as one piece and is of the same elastic, flexible material as the supporting wall, from which the diaphragm plug is separated along its perimetric edge by slots having a predetermined length. The diaphragm plug and the supporting wall are connected by at least two material bridges provided on opposite sides of the perimetric edge of the diaphragm plug, and the valve seat is configured as a shaped plate locked to the supporting wall in a position coincident with the diaphragm plug by a tightening ring, the valve seat and the tightening ring being engaged by elements passing through at least part of the slots.