Abstract: Provided herein are cross-reactive antibodies (or antigen binding fragments thereof) that bind to human CTLA4, activatable antibodies that bind to human CTLA4, nucleic acid molecules encoding the same, pharmaceutical compositions thereof, and methods of their therapeutic use (e.g., for treatment of cancer).

Abstract: The present invention provides a novel method of obtaining data for predicting the onset of an adverse event due to administration of at least one antibody drug selected from an anti-PD-1 antibody, an anti-PD-L1 antibody, an anti-CTLA4 antibody, and an antigen-binding fragment thereof, or a novel method of predicting the onset of the adverse event. More specifically, the present invention provides a method of obtaining data for predicting the onset of an adverse event or a method of predicting the onset of the adverse event, comprising measuring a level of at least one marker selected from sCD163 and CXCL5 in a biological sample collected from a subject administered the antibody drug.

Abstract: This invention relates to anti-PD-1 antibodies and methods of using them in treating diseases and conditions related to PD-lactivity, e.g., cancer.

Abstract: Provided herein are various embodiments relating to antibodies that bind LILRB2. Anti-LILRB2 antibodies can be used in methods to treat disease, for example, cancer.

Abstract: The present invention relates to compositions and methods for the immunomodulation mediated by the interaction of PD-L2 and RGMb.

Abstract: A novel PD-L1 antibody, an antigen-binding fragment thereof, and a pharmaceutical use thereof. A humanized antibody comprising a CDR of the PD-L1 antibody, a pharmaceutical composition comprising the PD-L1 antibody and the antigen-binding fragment thereof and a use of the PD-L1 antibody as a drug. A use of a humanized PD-L1 antibody in preparing a drug for treating diseases or disorders associated with PD-L1.

Abstract: Provided herein are variant CD80 polypeptides, immunomodulatory proteins comprising variant CD80 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.

Abstract: Provided herein are antibodies that selectively bind to complex comprising a non-classical HLA-I (e.g. HLA-E) and a neoantigen having variable heavy chain domains (VH), variable light chain domains (VL), and complementarity determining regions (CDRs) as disclosed herein, as well as methods and uses thereof.

Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to ?v?8 integrin. The invention includes uses, and associated methods of using the antibodies.

Abstract: Provided herein are antibodies specific for Interleukin-1 receptor accessory protein (IL1-RAP).

Abstract: The problem to be solved is to provide a humanized anti-IL-6 receptor antibody MRA-containing formulation which is suitable for subcutaneous administration, wherein dimerization or deamidation is prevented during long-term storage. The present application is directed to a stable antibody-containing liquid formulation characterized by containing arginine and histidine buffer. A method of inhibiting deamidation or dimerization of such an antibody in a concentrated liquid formulation includes histidine buffer in the liquid formulation.

Abstract: The present disclosure relates to the in vivo prevention or treatment of hematologic malignancy relapse using a TNFR2 antagonist (an anti TNFR2 antagonist antibody) (i) for use in the prevention or treatment of hematologic malignancy relapse after allogeneic hematopoietic stem cell transplantation (AHCT) or after a treatment with lymphocytes and (ii) for use in enhancing the graft-versus-leukemia-activity (GVL activity) of a hematopoietic stem cell transplantation (HCT) or a treatment with lymphocytes.

Abstract: The present disclosure provides antibodies that specifically bind to human OX40 receptor (OX40) and/or human GITR receptor (GITR), including multispecific antibodies that bind, e.g., to OX40 and GITR, and compositions comprising such antibodies. The antibodies disclosed herein modulate OX40 and/or GITR activity e.g., enhance, activate, induce, reduce, deactivate, or inhibit OX40 and/or GITR activity. The present disclosure also provides methods for treating disorders, such as cancer, autoimmune diseases or disorders, or inflammatory diseases or disorders, by administering an antibody that specifically binds to human OX40 and/or human GITR and modulates OX40 and/or GITR activity.

Abstract: The present invention relates to engineered anti-TNFR superfamily member antibodies having enhanced agonistic activity and methods of using them.

Abstract: The present invention relates to a method for preparing low molecular weight hyaluronic acid having a molecular weight of 100,000 to 200,000 daltons, the method comprising heating treatment, in the pH range 2.5 to 3.5, for an aqueous solution that contains hyaluronic acid having a molecular weight of 500,000 daltons or greater.

Abstract: The present invention relates to a composition for ophthalmological products, to corresponding copolymers and the preparation thereof and to the use thereof for the production of ophthalmic lenses or ophthalmological implants and to these products.

Abstract: Disclosed are a Z-N catalyst for ?-olefin polymerization and an application thereof, specifically, an industrial production catalyst consisting of (A) a solid catalyst component, (B) a cocatalyst organoaluminum compound and (C) an external electron donor compound and used for ?-olefin polymerization or copolymerization processes. The catalyst component is prepared from a transition metal such as titanium and magnesium and a composite aromatic diacid diester/1,3-diether as an internal electron donor. One or more organoaluminum compounds or a mixture thereof serve as the cocatalyst. One or more structure control agent hydrocarbyl alkoxysilicons are compounded with one or more activity regulator organic acid esters as the external electron donor capable of automatically adjusting the polymerization rate. The Z-N catalyst is used for ?-olefin polymerization/copolymerization, and can automatically adjust the polymerization rate at a higher polymerization temperature so as to maintain stable operation of a reactor.

Abstract: A flame retardant with which fire retardancy is improved and the fire retardancy is able to be secured stably for a long time is provided. An internal layer 11 containing a polymer and a flame retardant factor layer 12 that is formed outside of the internal layer 11 and that contains a polymer to which at least one of a sulfonate group and a sulfonate base is bonded are included. Thereby, compared to a case that the flame retardant factor layer 12 is not included, moisture is hardly absorbed, and respective particles of the flame retardant are inhibited from being adhered to each other. Accordingly, blocking is inhibited.

Abstract: The present invention relates to a novel process for preparing high-reactivity isobutene homo- or copolymers with a content of terminal vinylidene double bonds per polyisobutene chain end of at least 70 mol %. The present invention further relates to novel isobutene polymers.

Abstract: The present disclosure relates to a process for synthesizing a multi- or dual-headed composition by using an alpha,omega-diene and an organometallic compound in the presence of a catalyst precursor. The present disclosure further relates to use of the compositions, as well as the process to make the same, in olefin polymerization.

Abstract: The present invention provides an amine-based polymer, a preparation process thereof and use thereof. The amine-based polymer of the present invention is characterized in that said amine-based polymer contains a polymer main chain, and a structure represented by formula (I) is attached onto the polymer main chain, and said structure is attached to the polymer main chain via an attaching end present in at least one of Group G, Group G? and Group A in the structure, wherein each of the groups is defined as in the description. The amine-based polymer of the present invention is suitably used as a detergent, particularly suitably used as a fuel detergent. The amine-based polymer of the present invention is useful as a fuel detergent, and has an extraordinarily excellent detergency and dispersion properties.

Abstract: The present invention relates to a modifier represented by Formula 1, a method of preparing the same, a modified conjugated diene-based polymer having a high modification ratio which includes a modifier-derived functional group, and a method of preparing the polymer.

Abstract: The present disclosure relates to a capped, multi- or dual-headed chain composition comprising derivatives of a strained olefin. The present disclosure further relates to a process for synthesizing the capped, multi- or dual-headed composition by using an organometallic compound and a co-catalyst in the presence of a catalyst precursor and a strained olefin. The present disclosure further relates to use of the compositions, as well as the process to make the same, in olefin polymerization.

Abstract: A method for forming polar-functionalized polyolefins may comprise contacting an unsubstituted ?-olefin monomer and an amino-olefin monomer of formula H2C?CH(CH2)n(CHR)mNR?2, wherein R is H or an unsubstituted linear or branched alkyl group having from 1 to 10 carbons, each R? is an independently selected unsubstituted linear or branched alkyl group having from 1 to 10 carbons, m is an integer from 1 to 11, and n is an integer from 1 to 11, in the presence of a rare earth catalyst and a cocatalyst under conditions to induce a heteropolymerization reaction between the unsubstituted oc-olefin and amino-olefin monomers to provide a polar-functionalized poly olefin.

Abstract: Disclosed are a polyolefin having a high molecular weight by using a novel metallocene catalyst; a method for preparing the polyolefin by using the same; and a method for preparing an ethylene-propylene random copolymer having high molecular weight, high syndiotacticity and small crystal size, thereby providing injection molded articles with improved transparency.

Abstract: An endless belt includes a substrate layer, and a first surface layer that is disposed on an outer circumferential surface of the substrate layer and that includes a cross-linked fluororesin layer. A layer containing a cross-linked fluororesin forms the inner circumferential surface of the belt. Martens hardness of the inner circumferential surface of the belt at 130° C. is higher than Martens hardness of the outer circumferential surface of the belt at 130° C.

Abstract: The present invention relates to copolymers, to a method for the preparation of these copolymers, to the use of these copolymers for reducing wear in a lubricant composition, to lubricant compositions comprising these copolymers, and to the use of these lubricant compositions as an automatic transmission fluid, a continuously variable transmission fluid, an engine oil, a gear oil, or a hydraulic oil.

Abstract: The present invention relates to a polymeric composition comprising a polymer comprising monomers of methyl methacrylate and methacrylic acid. In particular the present invention relates to a process for making a polymeric composition suitable for moulded objects, said polymeric composition is comprising monomers of methyl methacrylate and methacrylic acid. The present invention concerns also process for making a moulded object comprising a polymer comprising monomers of methyl methacrylate and methacrylic acid. The present invention concerns also moulded object comprising a polymer comprising monomers of methyl methacrylate and methacrylic acid.

Abstract: The present disclosure discloses preparation and application of a novel multifunctional nanocomposite material with new photosensitizer, and belongs to the technical field of photodynamic therapy and the field of biomedicine. The photosensitizer multifunctional nanocomposite material provided by the present disclosure is prepared by self-assembly of cercosporin and an acid-sensitive copolymer multifunctional material with liver tumor cell targeting ability and traceability, wherein the acid-sensitive copolymer multifunctional material can be a copolymer of poly(N,N-dimethylaminoethyl methacrylate) and poly-3-azido-2-hydroxypropyl methacrylate covalently linked by galactose-modified rhodamine B.

Abstract: The invention relates to a continuous method for producing an isocyanurate-containing isocyanate mixture, in which in a step a) a mixture of a first and a second isocyanate component and an isocyanate group trimerization catalyst is provided; in a step b) the mixture obtained in step a) is reacted in a first residence time zone at an elevated temperature; in a step c), the reaction mixture obtained in step b) is further heated in a second residence time zone, optionally after adding a stopper; and in a step d), the reaction mixture obtained in step c) is cooled down in a third residence time zone by way of lowering the temperature, thus obtaining the desired isocyanurate-containing isocyanate mixture.

Abstract: An object of the present invention is to provide a polyurethane composition, in which reduction in the strength of the foam is suppressed when the foam has been greatly deformed. The present invention relates to a polyurethane composition comprising a base resin and a curing agent, wherein the base resin comprises a compound (A-1) comprising a polyalkylene skeleton comprising neither an aromatic skeleton nor an alicyclic skeleton, and having two or more functional groups having an active hydrogen atom, a compound (A-2) comprising an aromatic skeleton and/or alicyclic skeleton, and having two or more functional groups having an active hydrogen atom, a blowing agent (B), and an amine-based catalyst (C); a polyurethane foam therefrom; and a method for soundproofing and reinforcing a vehicle.

Abstract: Compositions and methods for forming epoxy resin systems are provided. In one embodiment, a composition is provided for an epoxy resin system including an epoxy resin blend comprising an epoxy resin, a first curing agent selected from the group of a polyarylene alkylphosphonate, a polyarylene arylphosphonate, and combinations thereof, and a second curing agent.

Abstract: The present invention provides a composition comprising a) at least one epoxy resin, b) at least one cyclic amine of the formula (I) in which R1 to R4 is H or an organic radical, with the proviso that at least one of the R1, R2, R3 and R4 radicals ?H, and X?—(Y1)m-(A1)n-(Y2)o-(A2)p-(Y3)q-(A3)r-(Y4)s—??(II) where, independently of one another, m, n, o, p, q, r and s=0 or 1, A1, A2, A3=alkylene or alkenylene radical and Y1, Y2, Y3, Y4?NR5, PR5, O or S, where R5 independently=organic radical, where any two organic radicals selected from R1 to R5 and any radicals present in the alkylene and/or alkenylene radicals A1, A2, A3 may also form one or more further rings, with the proviso that at least one of the radicals selected from R1 to R5 present and any radicals present in the alkylene and/or alkenylene radicals A1, A2, A3 is substituted by at least one —NHR6 or —NH2 group, where R6=organic radical, and c) at least one salt of a strong Brønsted acid with a counterion selected from metal ions, metal-co

Abstract: The present invention provides novel methods and processes for polymerizing unsaturated substrates, such as alkyne bearing monomers, with arenes. The polymerizations are catalyzed by gold (Au) catalysts/complexes and/or other cocatalysts. The invention further provides novel structurally complex polymers prepared in high yield via an intermolecular polyhydroarylation mechanism. Such resulting products comprise oligomeric and polymeric materials with novel molecular architectures and microstructures, which subsequently impart unique properties. The invention includes both the synthesis methods and processes and the resulting compounds and compositions of matter.

Abstract: A method for preparing tyrosine derived polyarylates includes combining a desaminotyrosyl-tyrosine ethyl ester, a desaminotyrosyl-tyrosine benzylester, succinic acid and a catalyst in a flask to produce a first mixture. Methylene chloride is added to the first mixture to produce a first suspension. Diisopropylcarbodiimide (DIPC) is added to the first mixture to produce a first solution. The first solution is added to a non-solvent to produce a precipitate. The precipitate is dissolved in methylene chloride to form a polymer solution. The polymer solution is blended with a slurry to produce polymer shreds. The polymer shreds are blended with a second slurry to produce a tyrosine derived polyarylate.

Abstract: The invention relates to microwave-resistant mouldings comprising at least one amorphous or microcrystalline copolyamide moulding compound, comprising at least one amorphous or microcrystalline copolyamide (A), said copolyamide (A) containing at least the following monomers: (a) at least one cycloaliphatic diamine, (b) 0.25 to 30 mol % of at least one dimeric fatty acid and (c) at least one aromatic dicarboxylic acid, where the proportions of all the monomers add up to 100 mol % and which has a glass transition temperature of at least 155° C. and a dielectric loss factor tan ? of not more than 8.30×10?3. The invention also relates to the use of an amorphous or microcrystalline copolyamide moulding compound comprising the copolyamide (A) for production of microwave-resistant mouldings.

Abstract: The present invention relates to a copolymer with a rigid polyamide block and a flexible polyether or polyester block, wherein said polyamide block is semicrystalline and consists of a copolyamide of W/Y.Z type, wherein: (i) W is a lactam or an alpha, omega-aminocarboxylic acid; (ii) Y is a cycloaliphatic diamine; (iii) Z is an aliphatic and/or aromatic dicarboxylic acid; and the W/Y.Z molar ratio is between 10/1 and 27/1 limits excluded.

Abstract: The present invention relates to a film-forming dispersion comprising a functionalized polyamide and water.

Abstract: Some embodiments are directed to sequence-defined polyurethanes and methods of making and using same.

Abstract: Provided are a thermosetting resin composition having especially good compatibility and having dielectric properties (low dielectric constant and low dielectric dissipation factor) in a high frequency range, high adhesion to conductor, excellent heat resistance, high glass transition temperature, low thermal expansion coefficient and high flame retardancy, and a prepreg, a laminate and a multilayer printed wiring board using the resin composition.

Abstract: Equilibrated trifluoromethanesulfonic acid-acidified ?,?-diacetoxypolydimethylsiloxanes, processes for the production thereof and SiOC-bonded, linear polydimethylsiloxane-polyoxyalkylene block copolymers of the structure type ABA and a process for the production thereof are described, wherein the production of SiOC-bonded, linear polydimethylsiloxane-polyoxyalkylene block copolymers of the structure type ABA is effected by reacting trifluoromethanesulfonic acid-acidified acetoxysiloxane with polyetherols optionally in the presence of buffer mixtures and optionally an additional condensation catalyst and optionally in the presence of an inert solvent.

Abstract: Provided is a lactic acid-based block copolymer which is biodegradable while having excellent mechanical properties.

Abstract: The present invention relates to processes and systems for preparing nanoparticles, cellular or viral membranes and/or cellular or viral membrane coated nanoparticles using or comprising, inter alia, a multi-inlet vortexing reactor, tangential flow filtration (TFF) and/or a high shear fluid processor such as a microfluidizer (or a microfluidizer processor). The present invention also relates to the nanoparticles, cellular or viral membranes and/or cellular or viral membrane coated nanoparticles prepared by the present processes and systems, and the uses and/or applications of the nanoparticles, cellular or viral membranes and/or cellular or viral membrane coated nanoparticles.

Abstract: A method of preparing polymer particles includes combining a polyetherimide and a solvent at a first temperature to provide a slurry, wherein the polyetherimide is not soluble in the solvent at the first temperature; heating the slurry to a second temperature and at a pressure effective to dissolve the polyetherimide in the solvent to provide a homogenous solution; cooling the homogenous solution to a third temperature to provide a dispersion including a plurality of polymer particles; and isolating the polymer particles. The polymer particles have a Dv90 particle size of less than or equal to 250 micrometers. Polymers powders prepared according to the method are also described herein, wherein the powder includes a plurality of semi-crystalline polymer particles having a Dv90 of less than or equal to 250 micrometers.

Abstract: There are provided a method of producing reclaimed carbon fibers in which, even if a carbon fiber reinforced resin is not heated at 800° C. or higher, pieces of carbon fiber base material that are contained in the carbon fiber reinforced resin can be directly collected, and the variation in the resin residue content in the collected pieces of carbon fiber base material can be reduced, a device for producing reclaimed carbon fibers that can be used in the production method, and a method of producing a carbon fiber reinforced resin in which reclaimed carbon fibers can be effectively used.

Abstract: In a first aspect, a polyimide film includes a dianhydride, a fluorinated aromatic diamine and an aliphatic diamine. The polyimide film has a b* of less than one for a film thickness of at least 30 microns and a glass transition temperature of less than 300° C. In a second aspect, an electronic device includes the polyimide film of the first aspect.

Abstract: Provided herein is a polymer composition comprising a polyhydroxyamino ether (e.g., a crosslinked polyhydroxyamino ether) and printed circuit boards comprising the same.

Abstract: Disclosed are hot-melt, curl-free methods, structures, and compositions, which in flexible packaging applications, reduce mineral-oil, hydrocarbon migration into packaged food. One embodiment provides an optionally oriented base film having a first side and a second side that is a transparent or opaque film. Further, the composition comprises, consists essentially of, or consists of a water-based primer applied to the first side. Further still, the composition includes a barrier layer to mineral-oil migration, wherein the barrier layer is located between the adhesive-receptive layer and the polymeric substrate, and wherein the barrier layer consists essentially of: (i) polymers of polyvinyl alcohol, ethylene vinyl alcohol, polyester, polyamide, or combinations thereof; and (ii) optionally additives. The barrier layer provides a barrier to mineral-oil migration of 0.1 ?g/day*dm2 or less at 40° C. for 40 days, and the curl-resistant composition does not curl when heated for at least one hour at 60° C.

Abstract: Provided is a composition for producing a graphite-polymer composite. A composition for producing a graphite-polymer composite according to an embodiment of the present invention is prepared by comprising: a heat radiation filler comprising a non-insulating filler and an insulating filler, the non-insulating filler comprising a graphite composite including nanoparticles combined to a surface of graphite and a catechol amine layer; and a matrix forming component comprising a thermoplastic polymer compound. According to the present invention, the composition leads to an improvement in insulation property of a heat radiation member and a minimization in deterioration of heat radiation performance of the heat radiation member, so that the utilization of the composition can be improved in industries requiring both heat radiation characteristics and heat insulation performance.

Abstract: A method for the direct fluorination of plastics and articles made from plastics is presented. The novel method includes ensuring extremely low oxygen and moisture content in the chamber before the primary fluorination step, ramping the fluorine concentration during the fluorination step, and providing a quenching step for improved shelf-life. Containers processed by the novel method demonstrate a marked improvement in barrier properties for organic solutions.