Abstract: Improved digital interfaces, graphical user interfaces, and alarms for analyte monitoring systems are provided. For example, disclosed herein are various embodiments of methods, systems, and interfaces for signal loss condition determination, Time-in-Ranges interfaces, GMI metrics, urgent low glucose alarms, alarm suppression features, alarm setup interfaces, and alarm unavailability detection features. In addition, various embodiments of interfaces for alarm logging and compatibility checking of an analyte monitoring software application are described. Also, various embodiments of interface enhancements are described, including an enhanced visibility mode, a voice accessibility mode, additional interfaces relating to user privacy, as well as caregiver alarms, among other embodiments.

Abstract: A method of managing insulin includes receiving blood glucose measurements on a computing device from a glucometer. The blood glucose measurements are separated by a time interval. The method includes determining, by the computing device, an insulin dose rate based on the blood glucose measurements and determining a blood glucose drop rate based on the blood glucose measurements and the time interval. The method also includes determining a blood glucose percentage drop based on the blood glucose measurements. The method includes decreasing the time interval between blood glucose measurements by the glucometer when the blood glucose drop rate is greater than a threshold drop rate, and decreasing the time interval between blood glucose measurements by the glucometer when the blood glucose percentage drop is greater than a threshold percentage drop.

Abstract: The present invention relates to a glucose detecting complex and a contact lens-type sensor comprising the same for detecting glucose in tears. The contact lens-type sensor for detecting glucose according to the present invention includes a complex in which glucose oxidase is coupled to cerium oxide nanoparticles. Such a configuration allows the visualization of changes in glucose concentrations and the quantitative measured of glucose in a simpler and more economical way. In addition, glucose concentrations can be monitored in real time through a non-invasive method by measuring the concentration of glucose in tears rather than in blood in comparison with the conventional blood glucose measurement method. Therefore, the present invention can be widely applied in the technical field for the early diagnosis and prevention of diabetes.

Abstract: An implantable inspecting device for inspecting an analyte in a liquid is provided, including a hollow carrier, a light source, a first polarizing member, a second polarizing member, and a sensor. The hollow carrier includes an accommodating space and at least one cavity portion communicated with the accommodating space. The light source, the first polarizing member, the second polarizing member, and the sensor are disposed in the accommodating space. The light from the light source passes through the first polarizing member, the liquid, and the second polarizing member to reach the sensor.

Abstract: A measuring device, intended to be placed on the skin of a human-being or animal user, the device extending between a contact face and a far end, the device including a side wall that extends between the contact face and the far end, on the contact face, at least one aperture to collect a gas of interest emitted through the skin, the aperture being produced through the contact face; a collecting chamber that extends between the contact face and a measuring chamber; a gas sensor, placed in the measuring chamber, to measure a concentration of gas of interest flowing through the measuring chamber; a processing unit, to estimate a gas-of-interest content in the body of the user based on the measurement taken by the gas sensor; a heat source to bring the contact face to a temperature above 37° C.; and an air intake produced through the side wall to admit ambient air into the duct.

Abstract: Apparatus for determining data indicative of blood oxygen levels of internal organs are disclosed.

Abstract: A device may identify a peak timestamp and a trough timestamp based on a first principal component of photoplethysmography (PPG) data associated with a plurality of wavelength channels. The device may generate a peak absorption spectrum based on the peak timestamp and the PPG data, and may generate a trough absorption spectrum based on the trough timestamp and the PPG data. The device may determine a measured arterial blood spectrum based on the peak absorption spectrum and the trough absorption spectrum. The device may fit the arterial blood spectrum model to the measured arterial blood spectrum to determine a set of values, each value in the set of values corresponding to a variable in a set of variables. The device may calculate an arterial oxygen saturation value based on one or more values of the set of values.

Abstract: A delivery device for delivering an instrument into a catheter assembly may include a syringe having a barrel and a plunger movable within the barrel. In response to depression of the plunger within the barrel, an instrument may be advanced distally. The instrument may include a catheter, a probe, a light tube for disinfection, or another suitable instrument. In response to depression of the plunger within the barrel, a distal end of the instrument may move through a catheter assembly coupled to the delivery device and into vasculature of a patient.

Abstract: A method for training a system for measuring or estimating or both of a user's response to a stimulus and for classifying the response is disclosed. The system is trained using a test stimulus presented to one or more users. One or more images of the users' face are captured and simultaneously EEG signals of the users are captured. One or more emotional features are derived from the facial data of the users. One or more cognitive features and emotional features are derived from the EEG signals of each of the users, and a training dataset is created by correlating the one or more emotional features from the facial data, one or more cognitive and emotional features from the EEG signals with one or more features associated with the test stimulus. Created training dataset is used for measuring or estimating or both of a user's response to the stimulus.

Abstract: The present disclosure provides a method for detecting the focus of attention. The method includes: obtaining the face of a person in the first image, as well as the result of facial recognition; determining whether the distance between the person and the target is within an effective attention range; determining whether the face is frontal; determining whether the effective attention period is not shorter than a period threshold; detecting the focus of attention for the person to the target.

Abstract: Various embodiments provide a muscle testing device. In an example embodiment, the muscle testing device comprises a frame comprising a central frame element and two arms extending therefrom. The distance between the arms is adjustable. The muscle testing device further comprises a first sensing pad (a) configured to be secured to a first arm of the two arms, (b) configured to measure a force or pressure applied to a sensing surface thereof, and (c) being moveable between a first position and a second position. When the first sensing pad is secured to the first arm in the first position, the sensing surface faces a second arm of the two arms. When the first sensing pad is secured to the first arm in the second position, the sensing surface faces away from the second arm. The muscle testing device may be part of a muscle testing kit.

Abstract: A method for measuring a neural response to a stimulus. Measurement circuitry is settled prior to a stimulus, by connecting a sense electrode to the measurement circuitry to allow the measurement circuitry to settle towards a bio-electrically defined steady state. Charge is recovered on stimulus electrodes by short circuiting the stimulus electrodes to each other. An electrical stimulus is then applied from the stimulus electrodes to neural tissue, while keeping the sense electrode disconnected from the measurement circuitry. After the stimulus, a delay is imposed during which the stimulus electrodes are open circuited and the sense electrode is disconnected from the measurement circuitry and from the stimulus electrodes. After the delay, a neural response signal present at the sense electrode is measured by connecting the sense electrode to the measurement circuitry.

Abstract: Epidermal electronics are non-invasive and non-obstructive skin mounted sensors with mechanical properties matching human epidermis. Their manufacturing process includes photolithography and dry and wet etching within cleanroom facilities. The high cost of manpower, materials, photo masks, and facilities greatly hinders the commercialization potential of disposable epidermal electronics. In contrast, an embodiment of the invention includes a low cost, high throughput, bench top “cut-and-paste” method to complete the freeform manufacture of epidermal sensor system (ESS) in minutes. This versatile method works for many types of thin metal and polymeric sheets and is compatible with many tattoo adhesives or medical tapes. The resultant ESS is highly multimaterial and multifunctional and may measure ECG, EMG, skin temperature, skin hydration, as well as respiratory rate.

Abstract: A patient-monitoring device includes a housing including a first opening, a snap located in the first opening to connect to an electrode through the first opening, and a dielectric potting compound covering the snap. A method of manufacturing a patient-monitoring device includes attaching a wire to a snap, providing a housing, providing a substrate including a connector and circuitry components, installing the snap into the housing, installing the substrate into the housing, providing a dielectric potting compound into the housing such that the dielectric potting compound covers the snap and the substrate, and curing the dielectric potting compound.

Abstract: Systems and methods for operating a biosensor are disclosed herein. In some embodiments, the biosensor is configured to access a user's interstitial fluid to determine the concentration of one or more analytes of interest. The method can include applying an excitation voltage to a working electrode of biosensor. The excitation voltage can be a time-varying waveform, such as a square waveform. The method can further include measuring a signal generated by the biosensor and analyzing the signal to determine one or more parameters of the biosensor and/or surrounding environment.

Abstract: Proposed is an electrocardiogram monitoring device for pets such as dogs and cats, the device including a pad that a pet climbs on a plurality of electrode bodies that are dispersedly disposed on an upper surface of the pad, and of which top portions are exposed, an electrode differentiation unit configured to select electrode bodies that are in contact with paw pads of the pet and that will receive electrical signals for electrocardiogram, and an electrocardiogram measurement unit configured to receive the electrical signals from the electrode bodies selected by the electrode differentiation unit and perform the electrocardiogram.

Abstract: Apparatus for precisely locating a distal end of a Central Venous Access Device (CVAD) including a cardiac monitor having a display screen and a first electrical input and a second electrical input. A first electrical lead wire has a first end electrically connected to the first electrical input of the cardiac monitor, and a second end to be electrically connected to a left side of a patient's body. A stylet is included having a proximal end and a distal end, wherein a second electrical lead wire having a first end is electrically connected to the second electrical input of the cardiac monitor, and a second end on the second electrical lead wire, and a first Quickly Attached/Quickly Released (QA/QR) electrical connector is attached to the second end of the second electrical lead wire. The first QA/QR electrical connector is electrically connected directly to the proximal end of the stylet. The first QA/QR electrical connector preferably is a hook clip.

Abstract: A medical device comprising a flexible electrode array having a bend radius of no more than about 2 mm; and a fluidic component, wherein the fluidic component is fluidically actuatable to cause the fluidic component to change configuration; wherein the fluidic component and the flexible electrode array are configured such that a change in configuration of the fluidic component causes a change in configuration of the flexible electrode array.

Abstract: Systems, methods, and computer program product embodiments are disclosed for performing electrophysiology (EP) signal processing. An embodiment includes an electrocardiogram (ECG) circuit board configured to process an ECG signal. The embodiment further includes a plurality of intracardiac (IC) circuit boards, each configured to process a corresponding IC signal. The ECG circuit board and the plurality of IC circuit boards share substantially a same circuit configuration and components. The ECG circuit board further processes the ECG signal using substantially a same path as each IC circuit board uses to process its corresponding IC signal.

Abstract: A medical device system, such as an extra-cardiovascular implantable cardioverter defibrillator ICD, senses R-waves from a first cardiac electrical signal by a first sensing channel and stores a time segment of a second cardiac electrical signal in response to each sensed R-wave. The medical device system determines a morphology parameter correlated to signal noise from time segments of the second cardiac electrical signal, detects a noisy signal segment based on the signal morphology parameter; and withholds detection of a tachyarrhythmia episode in response to detecting a threshold number of noisy signal segments.

Abstract: A device may receive electroencephalography data relating to one or more cerebral regions. The device may generate, based on the electroencephalography data, a cortical stimulation mapping model of the one or more cerebral regions, wherein the cortical stimulation mapping model includes one or more virtual inputs and one or more virtual outputs corresponding to the one or more cerebral regions. The device may apply a virtual impulse to the one or more virtual inputs. The device may determine a virtual after-discharge from the one or more virtual outputs, wherein the virtual after-discharge includes information relating to an electrical response to the virtual impulse. The device may generate, based on the virtual after-discharge, an index that maps a magnitude of the virtual after-discharge to the one or more cerebral regions. The device may cause an action to be performed based on the index.

Abstract: Automated assessment of neural response recordings involves storing a set of basis functions comprising at least one compound action potential basis function and at least one artefact basis function. Neural recordings of electrical activity in neural tissue are obtained by application of stimuli, using a single configuration of stimulation and recording. Each neural recording is decomposed by determining at least one parameter which estimates at least one of a compound action potential and an artefact. The at least one parameter is/are determined for each respective one of the plurality of neural recordings, to yield a plurality of values. A spread of the plurality of values is determined. An indication that the neural response recordings are of higher quality is output if the spread is small. An indication that the neural response recordings are of lower quality is output if the spread is large.

Abstract: The present disclosure relates to methods of treating or ameliorating hepatic encephalopathy (HE), including assessing the severity of HE in a patient suffering from HE, or the determining the presence or occurrence of an overt hepatic encephalopathy event. In particular, some aspects of the methods use a novel Hepatic Encephalopathy Staging Tool (HEST), which includes a set of criteria to categorize the HE into different stages and provide guidance on effective treatments based on the severity of the HE. Other aspects of the methods use an Overt Hepatic Encephalopathy Screening Tool (O-HEST) to determine whether an OHE event is occurring or has occurred and provide guidance on proper medical attention and change in treatment.

Abstract: A device and system for monitoring breast milk volume comprising a sensing module attached to a bra. The sensing module can include a processing unit configured to receive, store, and process readings measured by the sensing components of the module. The processing unit can be connected to a wireless transmitter that can be configured to transmit recorded and stored readings from the sensing module to a mobile device. The mobile device can display the transmitted data and further process the data to enable visualization of trends in the collected data.

Abstract: Systems, devices, and methods are described for generate at least one instances of a skin state and at least one instances of a personalized skincare recommendation responsive to receiving one or more inputs indicative of a predicted physiological cycle progression. The system includes a mitigation unit including computational circuitry configured to generate a personalized skincare recommendation responsive to one or more inputs indicative of the onset of the change in the skin state; and a skin-state display unit including computational circuitry configured to generate one or more instances of the skin state and one or more instances of a personalized skincare recommendation.

Abstract: A motor organ disease prediction device includes at least one processor, in which the processor derives a bone mineral density of a target bone among bones included in a subject including a bone part and a soft part, a muscle mass around the target bone, shape information representing a shape of the target bone, and shape information representing a shape of a bone adjacent to the target bone from a first radiation image and a second radiation image acquired by imaging the subject by radiation having different energy distributions. The processor derives a probability of occurrence of a motor organ disease relating to the target bone from the bone mineral density of the target bone, the muscle mass around the target bone, the shape information of the target bone, and the shape information of the bone adjacent to the target bone.

Abstract: Systems and methods for an intuitive display of one or more anatomical objects are provided. One or more 3D medical images of one or more anatomical objects of a patient are received. Correspondences between the one or more 3D medical images and points on a 2D map representing the one or more anatomical objects are determined. The 2D map is updated with patient information extracted from the one or more 3D medical images. The updated 2D map with the determined correspondences is output.

Abstract: An improved sleep onset/offset detection method based on a compact neural network that runs in a wearable device processing sensor data in near real-time, which means accumulating data from a few minutes instead of seconds before starting predictions.

Abstract: A blood vessel position display device (1) includes an image processing device (31) configured to subject an image for analysis of a target part (2) to image processing to acquire blood vessel information including positions and shapes of blood vessels included in the target part (2), a selection device (32) configured to choose blood vessels as conforming blood vessels in which a parameter obtained from the blood vessel information satisfies specific conditions, an image generation device (33) configured to generate a projection image including display lines at least set to have lengths corresponding to the conforming blood vessels, and a projection device (40) configured to cause the positions of the display lines to correspond to the positions of the conforming blood vessels so as to project the projection image on the target part (2).

Abstract: The present invention describes a system and method for selecting and optimizing a sound stimulus using a deep neural network to regulate and improve human sleep quality. The deep neural network has the capability of characterizing processing of human brain cortical neurons for external stimulus (images, sounds, etc.) information. By inputting massive sound stimuli into the deep neural network, a sound mode which causes model-estimated sleep electroencephalograph to be optimal can be found, the sound mode is applied to a real human body, and the intensity of corresponding sleep waves of the human body in different sleep stages is enhanced through closed-loop optimization so as to realize the purpose of regulating sleep. The present invention mainly aims at solving the technical problem of how to select and optimize, when a sound stimulus means (music, speech, natural sounds, white/colored noise, etc.) is used to assist in human sleep.

Abstract: Some implementations of the present invention relate to systems and methods for managing disruptive sleep disorders. In some cases the described systems and methods may detect an episode of parasomnia, such as sleep paralysis, sleepwalking, night terrors, chronic nightmares, sleep hallucinations, sleeping disorders associated with post-traumatic stress disorder, or a similar sleep disturbance, and provide a stimulus to wake the user from the episode of parasomnia. Accordingly, in some cases, the present invention comprises a sensor to monitor a user's physiological indicators to first determine if the user is asleep and then identify the onset of an episode of parasomnia, and a mechanism for providing a sensory stimulus to wake the user. Other implementations are also described.

Abstract: According to an aspect of the invention, there is provided a low back pain analysis device comprising: a processor; and a storage medium having computer program instructions stored thereon, wherein the computer program instructions, when executed by the processor, perform processing of: obtaining a relationship between a result of a pattern and a low back pain, using the result of the pattern obtained by classifying gravity center movement data acquired by a sensor, which is attached to furniture and acquires the gravity center movement data for a sitting period including a period for which a person is sitting on the furniture, using clustering.

Abstract: The present invention relates to a system for monitoring physiological parameters to an integrated digital system, which is able to determine several biological parameters, such as from photoplethysmographic (PPG) signals and other connected devices or sensors to give a personalized supplement, nutritional and lifestyle recommendation to improve specifically said parameters. By using new algorithms based on PPG signals the cardiovascular condition of a person can be analyzed by estimating cardiovascular parameters.

Abstract: An ergonomically designed smart wristband for clinical-grade multiparameter monitoring is disclosed. The smart wristband incorporates multiple sensors including custom-designed reflective arterial pulse sensors, a thermopile sensor, and electrocardiogram (ECG) electrodes. When the smart wristband is worn on the wrist, the biosensors contact the skin. The smart wristband may tether wirelessly to a mobile or any other computing device to continuously acquire and stream information like arterial pulse waveform and temperature data. Algorithms running on the computing device or onboard microprocessor analyze the acquired data to report parameters like blood pressure, body temperature, respiration, and blood oxygen. The device can also operate in a fully-standalone mode to accomplish continuous multiparameter physiological monitoring, analysis, and reporting.

Abstract: Systems, devices, methods, and kits for monitoring one or more physiologic and/or physical signals from a subject are disclosed. A system including patches and corresponding modules for wirelessly monitoring physiologic and/or physical signals is disclosed. A service system for managing the collection of physiologic data from a customer is disclosed. An isolating patch for providing a barrier between a handheld monitoring device with a plurality of contact pads and a subject is disclosed.

Abstract: A vital-signs patch for a patient monitoring system that includes a housing containing a sensor that makes physiological measurements of a patient, a transmitter, a receiver, a memory, and a processor. The processor periodically takes a measurement from the sensor, converts the measurement to a data record, and stores the data record in the memory. Upon receipt of a signal from another device, the processor retrieves at least a portion of the data record, converts the retrieved portion of the data record to a vital-sign signal, and causes the transmitter to transmit the vital-sign signal to the other device.

Abstract: A wearable cardiac monitoring device for providing an improved fit to a body of a patient during long term cardiac monitoring of the patient is provided. The device includes a garment configured to be worn about a torso of the patient and including a flexible material and physiological sensors configured to detect a physiological signal of the patient, the physiological sensors disposed on the flexible material and positioned at one or more anatomical locations of the patient's torso. The device also includes force applicators disposed on the flexible material proximate to the one or more physiological sensors, each of the force applicators configured to be adjustable during the long term cardiac monitoring of the patient to cause a pressure in a range of 0.05 psi to 0.65 psi to be exerted by the physiological sensors onto the one or more anatomical locations of the patient's torso.

Abstract: Non-invasive heartbeat sensor for determining a heart rate in a conduit of an extracorporeal blood treatment apparatus, comprising one source for directing an optical signal towards the blood flowing in the segment; one detector for receiving an optical informative signal comprising the signal emitted by said source after passing the blood, and emitting respective output signal; a controller receiving the respective output signal and retrieving a heartbeat frequency and a heart rate value, based on the output signal, wherein the informative signal is altered by flow perturbation of the blood partially generated by the flow impulses originated by the heart.

Abstract: In an embodiment, a data processing method comprises obtaining one or more photoplethysmography (PPG) signals from one or more PPG sensors of a monitoring apparatus, the PPG signals being generated based upon optically detecting pulsed variations in blood flow; obtaining a motion sensor signal from a motion sensor in the monitoring apparatus; identifying, based upon the motion sensor signal, one or more periods of motion (e.g., low motion) of the monitoring apparatus; and selectively obtaining and storing segments of the PPG signals based on a temporal relationship between the segments of the PPG signals and the identified periods of motion.

Abstract: According to various embodiments of the present invention, an electronic device may comprise a first sensor, a processor operably connected to the first sensor, and a memory operably connected to the processor, wherein the memory stores instructions that, when executed by the processor, cause the electronic device to: when a signal for measuring biometric information is detected, acquire depth information about a user of the electronic device from the first sensor; determine a position of a biometric reference point of the user, on the basis of the acquired depth information about the user; acquire a biometric signal relating to a measurement point of the user from the first sensor; calculate a distance between the measurement point and the biometric reference point; and correct biometric data about the user on the basis of the calculated distance and the acquired biometric signal. In addition to the various embodiments disclosed in the present invention, various other embodiments are also possible.

Abstract: Accurate, low cost detection of biological signals can be achieved by a biological signal estimation device provided with: a first measurement unit for measuring a first signal generated in a living body; a second measurement unit for measuring a second signal generated in the living body; a comparison unit for comparing characteristics of the first signal and the second signal; and an estimation unit for estimating a biological signal in the living body by performing signal processing on the first signal and the second signal on the basis of the result of comparison of the characteristics by the comparison unit.

Abstract: In some examples, a device includes processing circuitry configured to determine a set of correlation coefficient values for first and second physiological parameters. The processing circuitry is further configured to determine a metric of the correlation coefficient values for a first plurality of bins and for a second plurality of bins, wherein each bin of the first plurality has a first bin parameter and each bin of the second plurality of bins has a second bin parameter different than the first bin parameter. The processing circuitry is also configured to determine a composite estimate of a limit of autoregulation of the patient based on the metric for the first plurality of bins and the metric for the second plurality of bins. The processing circuitry is configured to determine an autoregulation status based on the composite estimate and output, for display via the display, an indication of the autoregulation status.

Abstract: Classification of heartbeats based on intracardiac and body surface electrocardiogram (ECG) signals are provided. Intracardiac ECG (IC-ECG) signals and body surface ECG (BS-ECG) signals are processed to perform heartbeat classifications. A BS annotation of BS-ECG signals reflective of a sensed heartbeat is defined, the BS annotation including a BS annotation time value. IC annotations of IC-ECG signals which reflect atrial-activity or ventricular activity of the sensed heartbeat are also defined, each IC annotation including an IC annotation time value. The IC-ECG signals are discriminated as A-activity or V-activity and IC annotations are designated as IC-A annotations or IC-V annotations, respectively. A respective A/V time sequence comparison of IC annotations reflective of the sensed heartbeat is made with one or more time sequence templates for heartbeat classification.

Abstract: There is disclosed a computer-implemented method of classifying electrocardiogram data of a patient, comprising the steps of receiving input data from each of a plurality of electrocardiogram leads, arranging the input data into a single combined image, and applying a machine-learning algorithm to the combined image to classify the electrocardiogram data.

Abstract: Systems and methods for monitoring physiological indicators that a patient is in distress can include a distress monitor comprising a band configured to be placed about and in contact with a portion of a body of the patient; a plurality of sensors configured to measure changes in the physiological indicators of the patient; and a controller contained within an electronics region of the band, the controller being electronically connected to each of the plurality of sensors to receive a respective output signal from each; and a display configured to receive an output signal from the controller and to display an alert when the patient is displaying indicators of physiological distress.

Abstract: Apparatus and methods for imaging a region of a subject comprising an artifact. In certain embodiments, the apparatus and methods utilize computed tomography (CT) scans obtained at two different angles to image a region posterior to an artifact.

Abstract: A gantry frame for a computed tomography system is described. The gantry frame comprises a cylindrical drum frame with a cylinder barrel which has a profiled barrel structure. A gantry is also described. Additionally, a computed tomography system is described. A method for manufacturing a gantry frame for a computed tomography system is also described.

Abstract: The invention relates, in particular, to features of an apparatus applicable for use in the context of dental or medical CT imaging. The apparatus comprises a two longitudinally extending frame parts 11, 21, a support construction 12 for an X-ray source 14 and an image detector 15 and a first driving mechanism 16 arranged to move them about a rotation axis 13.

Abstract: In general, radiation shielding systems that shield radiation from multiple directions are described. In one embodiment, method of shielding radiation is provided, including orienting the rigid radiation shield in a selected position relative to a patient, and attaching a flexible radiation shield to the rigid radiation shield such that the flexible rigid radiation shield includes a first generally vertical portion that covers a gap between the rigid radiation shield and the patient.

Abstract: For position sensors, e.g., a fiber-based system, that build a shape of an elongated member, such as a catheter, using a sequence of small orientation measurements, a small error in orientation at the proximal end of the sensor will cause large error in position at distal points on the fiber. Exemplary methods and systems are disclosed, which may provide full or partial registration along the length of the sensor to reduce the influence of the measurement error. Additional examples are directed to applying selective filtering at a proximal end of the elongated member to provide a more stable base for distal measurements and thereby reducing the influence of measurement errors.