Abstract: Methods for processing data acquired using ultrasound elastography, in which shear waves are generated in a subject using continuous vibration of the ultrasound transducer, are described. The described methods can effectively separate shear wave signals from signals corresponding to residual motion artifacts associated with vibration of the ultrasound transducer. The systems and methods described here also provide for real-time visualization of shear waves propagating in the subject.

Abstract: A system, device and method for imaging, measuring and identifying surface features in a tubular, such as a casing, wellbore, or pipe. The device comprises an ultrasound transducer for sonifying an area of the surface of the tubular, with a pulse intercepting axial locations of the sonified area at different times. Reflected signals are processed using their time of flight to interpret the reflected signals as axial locations of features on the surface of the tubular. Multiple sonified areas are partially overlapped in the axial direction to capture features redundantly. Reflections from the multiple areas are combined to remove noise and strengthen reflections from real features. A geometric model of the surface of the tubular is rendered and displayed. Capturing larger areas per frame increases the logging rate and oversampling improves the resolution and signal to noise ratio.

Abstract: A method and system of nanoscale photoacoustic tomography (nPAT) for non-invasive three-dimensional mapping and characterization of fine cellular structures (such as but not limited to organelles, vesicles, and macromolecules) of biological samples is disclosed.

Abstract: Described herein is a system for determining structural characteristics of an object, the system including a first laser, a second laser, one or more processors, and a computer readable medium storing instructions that, when executed by the one or more processors, cause the system to perform functions. The functions include illuminating, by the first laser, a surface region of an object with an incident light pulse, thereby causing the object to exhibit vibrations; illuminating, by the second laser, the surface region with an incident light beam, thereby generating responsive light that is indicative of the vibrations; detecting the responsive light and determining a difference between a characteristic of the responsive light and a reference characteristic that corresponds to the surface region; determining a position of the surface region within a three-dimensional space; and displaying the surface region such that the difference is indicated at the position of the surface region.

Abstract: A method for quantitatively evaluating the expected ultrasonic inspectability of a designed part using ray tracing. First, a model of a part imported. Materials having different indices of refraction are selected for the part and an acoustic coupling medium. Then the following structures and positional relationships are defined: an ultrasonic transducer array comprising a plurality of elements, a position of the acoustic coupling medium between the transducer array and the part, and a plurality of positions of a transmit aperture relative to the part. For each defined position of the transmit aperture, a path of a respective ray is traced from a center of the transmit aperture through the part and then to a respective receive location on the transducer array. Also, a respective value of an inspectability margin is calculated based at least in part on a respective distance between a center of the receive aperture and the respective receive location.

Abstract: To provide a method for evaluating a corroded part, the method making it possible to specify only a waveform reflected by a corroded part and to evaluate the waveform. When a transmission unit (2) is moved on the surface of a metal pipe (60) and the distance between a corroded part (5) and the transmission unit (2) is changed, only a waveform portion A of ultrasonic waves reflected by the corroded part (5) moves toward the left or right along an X axis, and only the intensity of a noise waveform portion B included in a received wave changes upward or downward along a Y axis, which makes it possible to separate the waveform portion A and the noise waveform portion B of a longitudinal-wave surface wave reflected by the corroded part (5) and evaluate the waveform portion A in detail.

Abstract: The present invention an apparatus and method of injecting a liquid borne sample into a field flow fractionator and a method of forming a top plate and spacer. In an embodiment, the field flow fractionation unit includes a top plate including a sample injection inlet port, a sample injection outlet port, and a spacer including a separation channel cavity defining at least a portion of the separation channel, a sample injection inlet cavity configured to be in fluid contact with the separation channel and located substantially beneath the sample injection inlet port, a sample injection outlet cavity configured to be in fluid contact with the separation channel and located substantially beneath the sample injection outlet port, such that the injection inlet and outlet paths are configured to define an injection channel that is essentially perpendicular to the length of the separation channel spanning the width of the separation channel cavity.

Abstract: A hydrogen flame ionization detector includes a nozzle configured to eject a sample gas upward, a cylindrical collector provided above the nozzle with a longitudinal direction thereof vertically oriented, the collector being configured to collect ions generated by a hydrogen flame formed at a tip of the nozzle, an insulator provided to hold the collector therein in such a manner as to extend in a radially inward direction of the collector, and a collector housing configured to accommodate the collector therein in such a manner as to surround an outer peripheral surface of the collector while holding a peripheral portion of the insulator. An accumulation suppression structure is provided above the insulator to suppress a material emitted from an upper end of the collector from being accumulated in such a manner as to shorten an insulation distance between the collector and the collector housing.

Abstract: A chromatography-mass spectrometry method and apparatus of the present invention includes adding, to a sample, an internal standard material having a retention time similar to that of a target analyte and having a mass-to-charge ratio different from that of the target analyte; measuring the sample with a chromatograph-mass spectrometer and obtaining a chromatogram 101 of the target analyte and a chromatogram 102 of the internal standard material; detecting a peak 113 from the chromatogram of the internal standard material and obtaining a peak start time and a peak end time of the peak; and applying the obtained peak start time and peak end time to a peak start time and a peak end time of the chromatogram of the target analyte.

Abstract: An odor is detected with high accuracy. A sensing system includes: a sensor apparatus including a filter to remove an odor-causing substance contained in air and a sensor unit including one or more detection elements to detect an amount of the odor-causing substance contained in air; and an information processing apparatus including a difference calculation unit to calculate a difference between a detection value of each of the one or more detection elements, the detection value indicating an amount of the odor-causing substance contained in air that has passed through the filter and a detection value of each of the one or more detection elements, the detection value indicating an amount of the odor-causing substance contained in air that has not passed through the filter, and a determination unit to determine an odor of air based on the calculated difference.

Abstract: A differential monitoring system of carbon dioxide levels within an associated building with a monitoring zone including a quantity of captured carbon dioxide and a reference zone that is spaced away from the monitoring zone. The differential monitoring system includes a first carbon dioxide monitoring inlet disposed within the monitoring zone. A second carbon dioxide monitoring inlet is disposed within the monitoring zone in spaced relation to the first carbon dioxide monitoring inlet and/or is disposed within the reference zone in spaced relation to the first carbon dioxide monitoring zone. A controller is operable to determine when a carbon dioxide level at the second carbon dioxide monitoring inlet exceeds a carbon dioxide level at the first carbon dioxide monitoring inlet by a predetermined differential threshold. The inlets can be part of an aspirated sampling system and/or part of a distributed sensor system. Methods of monitoring carbon dioxide levels are also included.

Abstract: Described herein is a chemical sensing system that can be deployed in an environment and automatically monitor the environment. The chemical sensing system includes one or more chemical sensing units with sensing elements that sense chemicals in the environment. The chemical sensing system analyzes measured values output by the sensing elements to identify patterns indicative of events. After identifying an event, the chemical sensing system may generate an inference about the environment using measured values output by the sensing elements during the event.

Abstract: The present invention relates to a method for the determination of processing influences on the quality of feedstuff raw materials and/or feedstuffs, in which the processing conditions indicator of the of feedstuff raw materials and/or feedstuffs is determined and the specific digestibility coefficient of an amino acid of a feedstuff raw material and/or feedstuff in an animal species is determined. The present invention also relates to a process for the optimization of feedstuffs considering the determined processing influences and the thus obtained and/or obtainable feedstuffs.

Abstract: A system for analyzing a fluid includes an in-line sensor configured to analyze a fluid flowing past the in-line sensor to determine at least one in-line value of a fluid parameter of the fluid across an event period, and a sample sensor configured to analyze a sample of fluid extracted from the flow of fluid during the event period, to determine sample value of the fluid parameter for the sample. At least one processor is provided, configured to determine a representative in-line value of the fluid parameter across the event period based at least in part on the at least one in-line value, and determine an overall representative value of the fluid parameter across the event period based on the representative in-line value, the sample value for the sample, and one or more of the in-line values corresponding to the time of extracting the sample, wherein determination of the overall representative value is based on an error correction value determined for the in-line sensor during the event period.

Abstract: The present disclosure relates to methods of verifying enhanced rock weathering using immobile trace elements found within a mineral amendment. Further disclosed are mineral amendments that enable enhanced rock weathering.

Abstract: Disclosed herein are methods for the detection of the presence of sperm DNA fragmentation in a semen sample. The methods include embedding of sperm cells of the semen sample in a gel, denaturing DNA of the sperm cells, and lysing the nuclear proteins of the sperm cells. The present method includes an ionic surfactant sodium dodycyl sulfate (SDS) and a chaotropic agent urea in the lysis solution for releasing DNA from protamine of chromosome, which significantly reduces the time required for lysis. A kit for detecting sperm DNA fragmentation in a semen sample is also disclosed.

Abstract: A rapid testing mechanism for respiratory viral pathogens includes a filter material positioned to capture exhaled breath particles from a respiratory tract. A portion of the filter material is impregnated with a pathogen binding adsorptive reagent. When the exhaled breath particles pass through the filter material the following occurs: when the binding adsorptive reagent reacts, a positive test for respiratory viral pathogens is indicated by the filter material; and when pathogen binding adsorptive reagent does not react, a negative test for respiratory viral pathogens is indicated by the filter material.

Abstract: A device (10), a substance measuring device (100), a process, a computer program, a camera (200) and a cell phone are provided for the unique and individual identification of a substance measuring device (100) of a test subject (300). The device (10) includes an optical identifier (12).

Abstract: A method is shown for preparing a specimen for extensively analyzing a resident skin bacterium and/or a substance present in the stratum corneum, such as a protein or a lipid, or observing the shape of the stratum corneum. A method for preparing a specimen for analyzing a resident skin bacterium and/or a substance present m the stratum corneum or observing the shape of the stratum, includes applying a solution containing a polyvinyl alcohol polymer to the skin so as to form a thin-film and peeling and collecting the formed thin-film.

Abstract: The present invention relates to the field of producing, identifying, and selecting biological binding molecules, e.g. in particular antibodies or fragments thereof, which selectively bind to somatically hypermutated B-cell receptors or B-cell receptor complexes. The method is used in order to select a biological binding molecule which specifically binds to a B-cell receptor having hypermutated regions as the target receptor, but not to a B-cell receptor without hypermutated regions, and is carried out in a cell-based system using immature B cells which are in the pro/pre stage and cause a ‘Triple Knockout’ of the genes for RAG2 or RAG1, Lambda5, and SLP65.

Abstract: Disclosed herein are methods for identifying novel drug candidates.

Abstract: A complex comprises a CRBN having a europium-anti-his antibody on the N-terminus of the CRBN, and a Cy5-conjugated small molecule, wherein the Cy5-conjugated small molecule binds the CRBN, and uses thereof for identifying therapeutic compounds.

Abstract: Metal-organic frameworks (MOFs) comprising amines on the organic linker can be used for cell targeting. In particular, primary amine groups represent one of the most versatile chemical moieties for conjugation to biologically relevant molecules, including antibodies and enzymes. Different chemical conjugation schemes can be used to conjugate biological molecules to the amino functionality on the organic linker. For example, carbodiimide chemistry can be used to link a primary amine to available carboxyl groups on the protein. For example, sulfhydryl crosslinking chemistry can be used via Traut's reagent scheme. As a demonstration of the invention, the ability of EpCAM antibody-targeted MOFs to bind to a human epithelial cell line (A549), a common target for imaging studies, was confirmed with confocal microscopy.

Abstract: A diagnostically useful carrier includes a peptide including the amino acid sequence set forth in SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4 or a variant thereof. A kit, a composition, a detection method, use for detecting a neurological disease, a human autoantibody specifically binding to Drebrin and a therapeutic compound or combination for use in the treatment of a neurological use are also useful.

Abstract: Embodiments may include an automated method for evaluating a sepsis status associated with a blood sample obtained from an individual. Methods may include determining a standard deviation of monocyte volume associated with the blood sample. Methods may include determining a white blood cell count (WBC) associated with the blood sample. Methods may include evaluating, using a data processing module, the sepsis status associated with the blood sample. The data processing module may include a processor and a computer application. This computer application may cause the processor to compare the standard deviation of monocyte volume with a first cutoff value to provide a comparison. The computer application may cause the processor to compare the WBC to a second cutoff to provide a second comparison. The computer application may also cause the processor to evaluate the sepsis status associated with the blood sample based on the first comparison and the second comparison.

Abstract: Disclosed herein are methods for diagnosing or prognosticating SARS-CoV-2 infection and/or COVID-19 in a subject. The methods set forth improved immunoassays, sensing platforms, and methods for detecting SARS-CoV-2 infection and re-infection.

Abstract: Methods for treating, preventing and predicting a subject's risk of developing breast cancer are provided.

Abstract: The present disclosure provides a method of treating cancer by immune checkpoint blockade, or selecting patients for treatment with immune checkpoint blockers, by detecting tumors with high levels of T-lymphocytes with low levels of activation and proliferation. In various embodiments the tissue sample may be from a conventional biopsy. In various embodiments the cancer may be non-small cell lung cancer.

Abstract: The present invention relates to compositions and methods for the prevention or the treatment of prostate cancer, wherein said compositions comprise an antibody binding to progastrin and said methods comprise the use of an antibody binding to progastrin.

Abstract: The present invention relates to inhibitors of HIF-1 and HIF-2 and uses thereof. The present invention further relates to the inhibitors for use in treatment of diseases. An isolated polypeptide is provided, that prevents dimerization of HIF-1? with HIF-1? and HIF-2? with HIF-1? and/or inhibits the activity of HIF-1 and HIF-2, wherein the polypeptide comprises the amino acid sequence C-X1-X2-X3-Z-X4 (SEQ ID NO: 1) and wherein X1, X2, X3 and X4 are any amino acid and wherein Z is leucine, valine of isoleucine or a non-natural derivative or leucine, valine or isoleucine. The isolated polypeptide prevents dimerization of HIF-1? with HIF-1? and HIF-2? with HIF-1? and inhibits the activity of HIF-1 and HIF-2 by binding to HIF-1? or HIF-1? and/or HIF-2? or HIF-1?.

Abstract: The present systems and methods are directed to de novo identification of peptide sequences from tandem mass spectrometry data. The systems and methods uses unconverted mass spectrometry data from which features are extracted. Using unconverted mass spectrometry data reduces the loss of information and provides more accurate sequencing of peptides. The systems and methods combine deep learning and neural networks to sequencing of peptides.

Abstract: This invention provides, and in certain specific but non-limiting aspects relates to: assays that can be used to predict whether a given ISV will be subject to protein interference as described herein and/or give rise to an (aspecific) signal in such an assay (such as for example in an ADA immunoassay).

Abstract: A method for predicting the risk of recurrence of Atrial Fibrillation in a subject based on measuring the amount of the biomarker Angiopoietin-2 (Ang-2) and optionally of at least one further biomarker in a sample from the subject is described. Also described is a method of diagnosing Atrial Fibrillation in a subject suspected to suffer from Atrial Fibrillation based on measuring the amount of the biomarker Angiopoietin-2 (Ang-2) and optionally of at least one further biomarker in a sample from the subject. Also described are devices adapted to carry out the method of the present disclosure.

Abstract: The present disclosure is directed to methods and kits for using serum biomarkers, including C-X-C Motif Chemokine Ligand 10 (CXCL10), C-X-C Motif Chemokine Ligand 13 (CXCL13), and/or soluble CD27 (sCD27), in predicting and evaluating therapeutic response to Tumor Necrosis Factor (TNF) inhibitor therapy in a patient in need thereof.

Abstract: The present invention provides a method for measuring growth hormone level in a human child, including a method of assessing pituitary-related growth hormone deficiency in a human child as a stand-alone test. The method includes the steps of oral administration of an effective amount of macimorelin to the child, collecting from the child two or three post-administration blood samples within a range of about 60 minutes after administration, and determining the level of growth hormone in the samples. The method can be used for diagnosing pituitary-related growth hormone deficiency in a child when the peak level of determined growth hormone in the samples is below a cut-off value.

Abstract: An embodiment of the disclosure is a rack adapted to engage a rack handler. The rack includes a rack body. The rack body has a bottom, a top opposite the bottom, and a receptacle that extends from the top toward the bottom. The receptacle is sized to receive the sample collection unit. The rack body has a first interior surface that extends from the bottom toward the top, and a second interior surface that extends from the bottom toward the top. The second interior surface is opposite to the first interior surface so as to at least partially define a slot along the bottom. The rack body also includes an interference groove in the slot along at least one of the first interior surface and the second interior surface. The slot and the interference groove are sized to engage a portion of the rack handler.

Abstract: An analysis device that includes a placement section, a pressing member, and a measurement member, has an analysis kit including a chip provided with a capillary through which a sample flows and a cartridge superimposed on the chip, and in which a liquid reservoir placed therein to enable a component present in sample can be measured in a state in which the chip and the cartridge have been fitted together. The analysis kit is placed on the placement section. The pressing member presses the analysis kit in a direction in which the cartridge is superimposed on the chip to sandwich the analysis kit between the pressing member and the placement section, and to fit the chip and the cartridge together. The measurement member that measures the component present in the sample in the analysis kit in which the chip and the cartridge have been fitted together.

Abstract: A method of measuring the speed of a fluid comprising the following steps: generating a plurality of pseudorandom frequencies (fus_n); for each pseudorandom frequency (fus_n), emitting ultrasound signals into the fluid to travel along a path of defined length; receiving the ultrasound signals; for each received ultrasound signal, producing a travel time measurement, so as to generate for each pseudorandom frequency (fus_n) a predefined number of travel time measurements; for each pseudorandom frequency (fus_n), evaluating the accuracy of the measurements; for evaluating the speed of the fluid, making use of the measurements produced for the pseudorandom frequency that presents the greatest accuracy.

Abstract: An atomic force microscope is provided having a controller configured to store one or more positional parameters output by a sensor assembly when a light spot is located at a first preset position on the surface of the cantilever. The controller is further configured to operate an actuator assembly so as to induce movement of the spot away from the first preset position, to detect said movement of the first spot based on a change in the one or more positional parameters output by the sensor assembly, and to operate an optical assembly in response to the detected movement of the first spot to return the first spot to the first preset position.

Abstract: A quantum-dot-based measuring system is disclosed. The quantum-dot-based measuring system includes a laser to emit excitation light, an optical fiber probe including a tail end and a tapered tip, and the tapered tip of the optical fiber probe is attached with one or more quantum dots, and the excitation light is injected from the tail end of the optical fiber probe and emitted from the tapered tip to a sample to be detected, an objective lens to collect optical signal reflected by the sample and a spectrometer to receive the optical signal.

Abstract: A probe assembly for a surface analysis instrument such as an atomic force microscope (AFM) that accommodates potential thermal drift effects includes a substrate defining a base of the probe assembly, a cantilever extending from the base and having a distal end, and a reflective pad disposed at or near the distal end. The reflective pad has a lateral dimension (e.g., length) between about twenty-five (25) microns, and can be less than a micron. Ideally, the reflective pad is patterned on the cantilever using photolithography. A corresponding method of manufacture of the thermally stable, drift resistant probe is also provided.

Abstract: The surface of the atomic force microscopy (AFM) cantilever is defined by a main cantilever body and an island. The island is partly separated from the main body by a separating space between facing edges of the main body and the island. At least one bridge connects the island to the main body, along a line around which the island is able to rotate through torsion of the at least one bridge. The island has a probe tip located on the island at a position offset from said line and a reflection area. In an AFM a light source directs light to the reflection area and a light spot position detector detects a displacement of a light spot formed from light reflected by the reflection area, for measuring an effect of forces exerted on the probe tip.

Abstract: The disclosure describes a novel method and apparatus for improving silicon interposers to include test circuitry for testing stacked die mounted on the interposer. The improvement allows for the stacked die to be selectively tested by an external tester or by the test circuitry included in the interposer.

Abstract: A sensor device for detecting voltage in a conductor cable includes a sense electrode to be disposed over a surface of the conductor cable to cover a sense region having a sense axial width and a sense circumferential length and a reference electrode to be disposed over the surface of the conductor cable to cover a reference region. The reference region has an axial position adjacent the axial position of the sense region and has a reference circumferential length greater than the sense circumferential length. The sensor device further includes a charge measurement circuit connected in series between the sense electrode and the reference electrode to measure a charge measurement and circuitry to compare the charge measurement to a threshold to detect a presence of the voltage in the conductor cable.

Abstract: A sensor assembly includes a connecting bar extending along a longitudinal axis and a tubular body extending along the longitudinal axis and at least partially surrounding the connecting bar such that the tubular body is radially spaced from the connecting bar. The tubular body includes a support member made of insulating material. The tubular body also includes a first section with an electric field sensor comprising a first layer of electrically conductive material on an inner surface of the support member to detect an electric field produced by the connecting bar. The first section also includes a first electric screen comprising a second layer of electrically conductive material on an outer surface of the support member to shield the electric field sensor from outside electrical interference. A second section disposed adjacent the first section includes a second electric screen. A dielectric material at least partially encloses the tubular body.

Abstract: A current sensor integrated circuit configured to sense a current through a current conductor includes a lead frame at least one signal lead, a fan out wafer level package (FOWLP), and a mold material enclosing the FOWLP and a portion of the lead frame. The FOWLP includes a semiconductor die configured to support at least one magnetic field sensing element to sense a magnetic field associated with the current, wherein the semiconductor die has a first surface on which at least one connection pad is accessible, a redistribution layer in contact with the at least one connection pad, and an insulating layer in contact with the redistribution layer, wherein the insulating layer is configured to extend beyond a periphery of the semiconductor die by a minimum distance. The die connection pad is configured to be electrically coupled to the at least one signal lead.

Abstract: A power circuit includes at least one power detector coupled to both a first power voltage input via a pin or pad and a second power voltage supplied into a component, and configured to output a sensed power voltage changed from the first power voltage in response to a drop of the second power voltage, and a comparator configured to compare the sensed power voltage with a reference voltage to output a power sensing result.

Abstract: An integrated circuit including a comparator having a first input to receive a reference voltage, a second input, and an output to provide an under-voltage indicator. Sense points are configured to provide a plurality of sense point voltages, each sense point providing a corresponding sense point voltage of the plurality of sense point voltages; and a minimum voltage tracking circuit configured to receive the plurality of sense point voltages and provide an output voltage which tracks whichever sense point voltage of the plurality of sense point voltages is currently a minimum sense point voltage. The comparator receives the output voltage at the second input and asserts the under-voltage indicator when the output voltage is below the reference voltage.

Abstract: A direct current (DC) power rail probe includes a single-ended probe tip, and a two-path circuit having an input coupled to the single-ended probe tip and an output configured for connection to measurement equipment such as an oscilloscope. The two-path circuit includes an alternating current (AC) path in parallel with a feed-forward (FF) path, the AC path including a capacitive element, and the FF path including a series connection of at least one resistive element and an amplifier. The probe tip and two-path circuit are selectively operable in a non-attenuating mode and an attenuating mode.

Abstract: It is provided a current recording method, a current recording device and a current recording system by the embodiments of this disclosure. The current recording method comprises: acquiring a first current Fourier value, the first current Fourier value being a Fourier value acquired by Fourier transforming an instantaneous value of current at a first end of a power line; acquiring a second current Fourier value, the second current Fourier value being a Fourier value acquired by Fourier transforming an instantaneous value of current at a second end of the power line; time-alignment the first current Fourier value and the second current Fourier value, based on a first transmission delay for acquiring the first current Fourier value and a second transmission delay for acquiring the second current Fourier value; storing the aligned first current Fourier value and second current Fourier value into a storage.