Patents Issued in August 1, 2023
  • Pneumatic system blockage detection
    Patent number: 11712386
    Abstract: A patient support apparatus pneumatic system may include a mattress defining an interior and a pneumatic enclosure in fluid communication with the interior and comprising an inlet and an outlet. A blower may be in fluid communication with the interior and the pneumatic enclosure. A pressure sensor may be configured to detect a pressure at the outlet. A controller may be configured to monitor a speed of the blower and the pressure at the outlet for detecting at least one of an intake blockage condition and an exhaust blockage condition.
    Type: Grant
    Filed: July 13, 2020
    Date of Patent: August 1, 2023
    Assignee: Hill-Rom Services, Inc.
    Inventors: Brandon Fisk, Jnanesha Ramegowda, Gregory John Shannon, Frank Sauser, Michael Churilla
  • Table mount for a touchscreen device
    Patent number: 11712387
    Abstract: The present disclosure is directed to table mount for mounting a touchscreen device to a surgical table. The table mount includes a clamp configured to releasably secure the table mount to the table, a first arm rotatably connected to the clamp and configured to extend vertically from the surgical table, a second arm rotatably connected to the first arm, and a touchscreen device docking assembly rotatably connected to the second arm and configured to hold a touchscreen device.
    Type: Grant
    Filed: April 20, 2021
    Date of Patent: August 1, 2023
    Assignee: Stryker Corporation
    Inventors: Brian Fouts, Lauren Thomas
  • Device for blood loss measurement following childbirth to detect postpartum hemorrhage
    Patent number: 11712388
    Abstract: A device for detecting postpartum hemorrhage is provided. A mat defines a proximal end and a distal end. The mat is configured to be disposed between a support and a patient and has a surface with a fluid flow region configured to direct flow of bodily fluids from the patient towards the distal end of the mat. A first detachable and optionally sealable bag is configured to receive the bodily fluids from the patient in a first operational mode of the device. A second sealable bag is configured to receive the bodily fluids from the patient in a second operational mode of the device. The second sealable bag comprises a visual volume indicator to measure the bodily fluids collected in the second sealable bag.
    Type: Grant
    Filed: March 10, 2021
    Date of Patent: August 1, 2023
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Celia Clark, Katie Munson, Shriya Suresh, Yvonne Wu, Sanghamithra Kalimi, Nisha Bharat, Jeffrey Stephen Plott, Chun Hei So, Gene Philip Parunak, Jahnavi Nalamolu
  • Device with therapeutic features
    Patent number: 11712389
    Abstract: A therapeutic stretching apparatus, which, in particular, provides a user with a system for providing assistance to increase knee extension as well as for maintaining stability of the knee after surgery. This device can not only act as a therapeutic stretching apparatus but also can act as a primary post-op knee brace with locks/limits on hinge to prevent user from further injuring the joint.
    Type: Grant
    Filed: May 30, 2020
    Date of Patent: August 1, 2023
    Assignee: ERMI, LLC
    Inventors: Thomas P. Branch, Edward S. Dittmar, Timothy James Shary, Shaun Kevin Stinton, Nathaniel K. DeJarnette
  • Oral rehabilitation device and medical treatment system therewith
    Patent number: 11712390
    Abstract: An oral rehabilitation device for rehabilitating the oral cavity of a user includes a device body, a first activating member, an upper-jaw member, a lower-jaw member, and a processing unit. The first activating member is disposed on an end of the device body. The upper-jaw member and the lower-jaw member are connected to the same end of the device body and are for contacting an upper jaw and lower jaw of the user, respectively. The processing unit is coupled to the first activating member and is used to control the first activating member to drive one of the upper-jaw member and the lower jaw member to open or close relative to the other of the upper-jaw member and the lower-jaw member, such that the upper jaw and the lower jaw can be rehabilitated. The present invention further discloses a medical treatment system to which the oral rehabilitation device is linked.
    Type: Grant
    Filed: October 8, 2019
    Date of Patent: August 1, 2023
    Assignee: CHANGHUA CHRISTIAN MEDICAL FOUNDATION CHANGHUA CHRISTIAN HOSPITAL
    Inventors: Mu-Kuan Chen, Gene Chen, Po-Te Lin, Chih-Hua Chen, Ming-Yu Hsieh, Mei-Hui Chang
  • State estimation program, trained model, rehabilitation support system, learning apparatus, and state estimation method
    Patent number: 11712391
    Abstract: A state estimation program is for causing a computer to function to determine a state of training in a rehabilitation support system used by a trainee to perform training of a preset motion and includes a threshold setting step and a state estimation step. The threshold setting step is for acquiring a sensor output, the sensor output being an output of a sensor included in the rehabilitation support system in the training performed by the trainee and setting a threshold for determining one of a normal state and an abnormal state of the training based on the sensor output. The state estimation step is for estimating whether the training is performed in the normal state or the abnormal state based on the threshold.
    Type: Grant
    Filed: July 1, 2020
    Date of Patent: August 1, 2023
    Assignee: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Nobuhisa Otsuki, Issei Nakashima, Manabu Yamamoto
  • Calf stretching apparatus
    Patent number: 11712392
    Abstract: A calf stretching apparatus that includes a base placeable on a ground surface and a foot placement platform with a front end, a rear end, a platform surface spanning in an upward direction with respect to the base from the front end to the rear end and with a portion disposed at an acute angle with respect to a lower surface plane, and a platform sidewall positioned upright with respect to the platform surface and including an upper edge and an arcuate heel sidewall portion having a heel pad member disposed proximal to the front end of the foot placement platform. The heel pad member has two opposing heel placement sidewalls spanning upwardly away from the platform surface toward the upper edge and converging to an internal heel placement support wall, that define a heel placement recess disposed above the platform surface and configured to receive a user's heel.
    Type: Grant
    Filed: February 16, 2021
    Date of Patent: August 1, 2023
    Inventor: David Barouche
  • Pelvis fixing device and motion assistance apparatus including the same
    Patent number: 11712393
    Abstract: Provided is a pelvis fixing device including a rear fixing module including a driving module mounting portion, the rear fixing portion configured to enclose a side surface and a rear surface of a waist of a user, and a front fixing module including a soft layer and a hard layer configured to enclose a front surface of the waist of the user, wherein the hard layer is connected to the rear fixing module to form a closed loop around the waist of the user.
    Type: Grant
    Filed: June 4, 2021
    Date of Patent: August 1, 2023
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Jongwon Lee, Minhyung Lee, Youn Baek Lee, Jeonghun Kim, Se-Gon Roh, Byungjune Choi, Hyun Do Choi
  • Shock absorbing ferrule for assisted ambulation
    Patent number: 11712394
    Abstract: A shock absorbing ferrule for a shaft of a crutch, an elbow/forearm crutch, a walker and other devices used during assisted ambulation, wherein the shock absorbing ferrule mitigates impact, potentially reducing injury during their use. The shock absorbing ferrule includes a ferrule having a viscoelastic walled cylindrical socket, which is an annular longitudinal cavity fitted with a shock absorbing assembly. The shock absorbing assembly includes at least one compression spring and a push plate. The compression spring has an outside diameter that is less than the inside diameter of the socket and is seated on the metal distribution washer and under the push plate. The push plate is a metal disk with a smooth perimeter edge having an upper side that is in abutment with an end of the shaft and a lower side that is in abutment with the compression spring.
    Type: Grant
    Filed: January 11, 2023
    Date of Patent: August 1, 2023
    Inventor: Anthony L. Spatorico
  • Uniform grip and gradient cushioning gain for footwear sole arrangement
    Patent number: 11712395
    Abstract: A sole arrangement for an article of footwear with a gradient depth value is provided. In one aspect of the disclosure, the sole arrangement extending from an end of a posterior area of the sole arrangement to an end of an anterior area of the sole arrangement, wherein the posterior area of the sole arrangement being formed under a heel area and the anterior area of the sole arrangement being formed under a forefoot area of a foot. The sole arrangement having an upper facing surface and a ground engaging surface, wherein the upper facing surface being on an opposite side of the sole arrangement than the ground engaging surface. The sole arrangement having a maximum posterior depth value. The sole arrangement having a maximum anterior depth value. The maximum posterior depth value may be smaller than the maximum anterior depth value by a first margin.
    Type: Grant
    Filed: May 23, 2022
    Date of Patent: August 1, 2023
    Assignee: ANTEPES, LLC
    Inventor: Shahriar Behnamian
  • Exercise equipment for transportation of article of footwear
    Patent number: 11712396
    Abstract: A sole arrangement for an article of footwear with a gradient depth value is provided. In one aspect of the disclosure, the sole arrangement extending from an end of a posterior area of the sole arrangement to an end of an anterior area of the sole arrangement, wherein the posterior area of the sole arrangement being formed under a heel area and the anterior area of the sole arrangement being formed under a forefoot area of a foot. The sole arrangement having an upper facing surface and a ground engaging surface, wherein the upper facing surface being on an opposite side of the sole arrangement than the ground engaging surface. The sole arrangement having a maximum posterior depth value. The sole arrangement having a maximum anterior depth value. The maximum posterior depth value may be smaller than the maximum anterior depth value by a first margin.
    Type: Grant
    Filed: May 23, 2022
    Date of Patent: August 1, 2023
    Inventor: Shahriar Behnamian
  • System, method, and non-transitory storage medium for providing online entertainment in association with an interactive adult toy
    Patent number: 11712397
    Abstract: An online entertainment system for facilitating interaction between a model hosting an online streaming video session and at least one viewer. The model operates an operable adult toy with which the at least one viewer can interact, either directly or indirectly, during the online streaming video session. The system provides the viewer with an interface with which the viewer can engage to participate in a game of chance. A result of the game of chance is used to obtain predetermined feedback parameters, actual feedback obtained from the adult toy during manipulation thereof by the model is compared against the predetermined feedback parameters, and control is performed based on a result of the comparison.
    Type: Grant
    Filed: July 29, 2022
    Date of Patent: August 1, 2023
    Assignee: HYTTO PTE. LTD.
    Inventors: Dan Liu, Jilin Qiu
  • Systems and methods for head up cardiopulmonary resuscitation
    Patent number: 11712398
    Abstract: A method for performing cardiopulmonary resuscitation (CPR) includes elevating the heart of an individual to a first height relative to a lower body of the individual. The lower body may be in a substantially horizontal plane. The method may also include elevating the head of the individual to a second height relative to the lower body of the individual. The second height may be greater than the first height. The method may further include performing one or more of a type of CPR or a type of intrathoracic pressure regulation while elevating the heart and the head. The first height and the second height may be determined based on one or both of the type of CPR or the type of intrathoracic pressure regulation.
    Type: Grant
    Filed: August 2, 2021
    Date of Patent: August 1, 2023
    Inventor: Keith Lurie
  • Chest compression machine systems and methods
    Patent number: 11712399
    Abstract: Chest compression machine systems and methods adjust the administration of patient treatment based on received physiological parameter measurements, such as a CO2 measurement. Adjustment of the administered chest compressions can include adjusting one or more chest compression parameters, such as the depth of the administered compressions, the administration of active decompressions, adjusting the height of active decompression, adjusting the rate of compressions and/or active decompressions and/or other changes to one or more properties, or characteristics, of the administered chest compressions and/or active decompressions.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: August 1, 2023
    Assignee: STRYKER CORPORATION
    Inventors: Erik von Schenck, Bjarne Madsen Härdig, Anders Nilsson
  • Elastically woven face cradle
    Patent number: 11712400
    Abstract: An objective of the present invention is to provide users a face cradle that form-fits to the unique contours of a user's face, as the user suspends their face within the elastic woven components of the face cradle. Accordingly, the present invention provides an apparatus comprising of a structure that holds a webbed elastic face rest. Preferably, the present invention comprises an arch shaped webbing formed over a rigid structure. According to a preferred embodiment, the present invention is shaped similar to that of a vortex or torus that can stretch, and form fit to the user's head/face with no pressure points. Furthermore, the present invention may exist as a standalone structure, or a removable attachment to a previously existing structure for attaching to a treatment table.
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: August 1, 2023
    Inventor: Jacob Kemp
  • Pill bottle container insert
    Patent number: 11712401
    Abstract: A lightweight pill container headspace occupying insert apparatus is disclosed that can be configured to conform to the general shape of an inner region of a pill container, such that the insert occupies or fills in the open or headspace the pill container thereby preventing movement of one or more pills or tablets within the container, among other advantages. The insert can include a biasing member having a first end and a second end, a first disc secured to the first end of the biasing member and a second disc secured to the second end of the distal member, wherein the first disc and second disc are configured to substantially align with an interior space of a pill container.
    Type: Grant
    Filed: December 31, 2020
    Date of Patent: August 1, 2023
    Inventor: Osman Yusuf
  • Multi-mix infusion bag
    Patent number: 11712402
    Abstract: A multi-mix infusion bag is provided. The multi-mix infusion bag includes a lower portion and an upper portion. The lower portion has a lower chamber and the upper portion includes a plurality of chambers. Each chamber is separated and contains a fluid agent. The multi-mix infusion bag is configured to transfer each fluid agent within each chamber of the upper portion into the lower chamber for mixing. The multi-mix infusion bag may include dispensing devices associated with each chamber, wherein the dispensing devices operate to transfer the fluid agents into the lower chamber for mixing.
    Type: Grant
    Filed: December 9, 2019
    Date of Patent: August 1, 2023
    Inventors: Tomas A. Caquias, Jesus A. Caquias
  • Disposable absorbent stoma pad for gastrostomy
    Patent number: 11712403
    Abstract: An absorbent stoma pad for encapsulating an external bolster of a feeding tube is provided. The stoma pad includes an upper layer, base layer, absorbent material, and cavity. The upper layer, which includes an upper surface and a lower surface, contains a centrally located opening with respect to a periphery of the upper layer, wherein the opening is configured to receive a tube portion of the feeding tube. The base layer, which includes an upper surface and a lower surface, contains a centrally located opening with respect to a periphery of the base layer, wherein the opening is also configured to receive the tube portion of the feeding tube. Meanwhile, the absorbent material is disposed adjacent the upper layer's lower surface. Further, the cavity permits airflow between the absorbent layer and the base layer when the external bolster is encapsulated by the stoma pad and positioned within the cavity.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: August 1, 2023
    Assignee: O&M Halyard, Inc.
    Inventor: Donald McMichael
  • Methacrylamide adhesive systems
    Patent number: 11712404
    Abstract: Provided are compositions useful as dental adhesives comprising an acrylamide compound, a methacrylate base monomer, a polymerization initiator, and a polymerization inhibitor or a polymerization stabilizer.
    Type: Grant
    Filed: February 26, 2019
    Date of Patent: August 1, 2023
    Inventors: Wilbes Mbiya, Carmem Silvia Costa Pfeifer, Jack Liborio Ferracane
  • Method for the remineralization of teeth
    Patent number: 11712405
    Abstract: Composition for use in the remineralization of teeth, which comprises a fluoride-containing component and a calcium-containing component, wherein the calcium-containing component contains a nanoparticulate calcium salt and the composition is designed for the successive application of the fluoride-containing component and the calcium-containing component to the tooth surface, wherein the fluoride-containing component is applied to the tooth before the calcium-containing component.
    Type: Grant
    Filed: January 16, 2019
    Date of Patent: August 1, 2023
    Assignee: Ivoclar Vivadent AG
    Inventors: Urs Lendenmann, Carlo Bolis
  • Oil-in-water emulsion cosmetic
    Patent number: 11712406
    Abstract: An oil-in-water type emulsified cosmetic and a method of making can be prepared in a system not containing a silicone and is surprisingly produced without a wet-type dispersion apparatus by using a specific combination of the oil component constituting the oily phase and a hydrophobizing agent for a hydrophobized powder. The composition includes an aqueous phase; an oily phase dispersed in the aqueous phase; and a powder dispersed in the oily phase. The oily phase comprises a volatile hydrocarbon in oil in a combined amount of 40% by mass or more with respect to the total oil content. The powder has a surface hydrophobized by treatment with a metallic soap consisting of a higher fatty acid and a divalent metal, or by a composite treatment with a higher fatty acid and a divalent metal hydroxide.
    Type: Grant
    Filed: December 6, 2021
    Date of Patent: August 1, 2023
    Assignee: SHISEIDO COMPANY, LTD.
    Inventors: Shun Kubota, Hideo Hata, Malyn Concina, Michelle Lou, Hideki Takahashi, Julie Shown, Yosuke Ikebe
  • Hybrid-type multi-lamellar nanostructure of epidermal growth factor and liposome and method for manufacturing same
    Patent number: 11712407
    Abstract: The present invention relates to a hybrid-type multi-lamellar nanostructure of an epidermal growth factor and a liposome and a method for manufacturing same. The new type of hybrid-type multi-lamellar nanostructure not only has a high epidermal growth factor encapsulating efficiency, but also can be manufactured through a simple process, such that the same can be easily delivered into a living body or a cell while maintaining a high physiological activity of the epidermal growth factor.
    Type: Grant
    Filed: December 30, 2015
    Date of Patent: August 1, 2023
    Assignees: CELLTRION, INC., Korea Advanced institute of Science and Technology
    Inventors: Yoon Sung Nam, Sung Duk Jo, Bon Il Koo
  • Semisolid oral dispersions comprising active agents
    Patent number: 11712408
    Abstract: The semisolid oral dispersions include hydrophilic active agent particles in hydrophobic phase. The hydrophilic active agent particles can include bleaching agents, antimicrobial agents, anticalculus agents, and/or combinations thereof. The hydrophilic active agent particle can have a solubility in water of at least about 20 parts, by weight of the particles, in about 100 parts, by weight, of water.
    Type: Grant
    Filed: April 8, 2020
    Date of Patent: August 1, 2023
    Assignee: The Procter & Gamble Company
    Inventors: Paul Albert Sagel, Jayanth Rajaiah, Michael David Curtis
  • Alcohol containing low-water cleansing composition
    Patent number: 11712409
    Abstract: A low-water cleansing composition is provided that includes 5.0 wt. % to less than 40 wt. % of one or more C1-C8 alcohol, at least 10.0 wt. % of a mixture of two or more surfactants, at least 0.05 wt. % of a pH adjuster; and water, the concentrations being based on a total weight of the low-water cleansing composition.
    Type: Grant
    Filed: November 1, 2021
    Date of Patent: August 1, 2023
    Assignee: GOJO Industries, Inc.
    Inventors: Venkatesan Padyachi, Srini Venkatesh, Daniel M. Willis, Nick E. Ciavarella, Dewain Garner
  • Composition for improving hair health
    Patent number: 11712410
    Abstract: A composition comprising two peptides with a size of 11 and 12 amino acids, wherein 2-3 of said amino acids are cysteines and a suitable dermatology excipient, which can be used for treatment and grooming products for animal hair, preferably for treatment and cosmetics for human hair.
    Type: Grant
    Filed: September 5, 2018
    Date of Patent: August 1, 2023
    Assignee: K18, INC.
    Inventors: Suveen Sahib, Elsa Jungman
  • Lip compositions capable of forming a multilayer structure after application to lips
    Patent number: 11712411
    Abstract: Lip compositions including at least one semi-crystalline acrylate copolymer, wherein the compositions include at least two components prior to mixing and application to lips and are capable of forming a multilayer structure after application to lips, are provided.
    Type: Grant
    Filed: October 29, 2020
    Date of Patent: August 1, 2023
    Assignee: L'OREAL
    Inventors: XianZhi Zhou, Tsang-Min Huang, Jody Ebanks, Mariko Hasebe, Hy Si Bui, Chunhua Li, Rita Jaky El-Khouri, Rabia Ahmad
  • Cosmetic compositions capable of forming a multilayer structure after application to a keratinous material
    Patent number: 11712412
    Abstract: Cosmetic compositions capable of forming a multilayer structure after application to a keratinous material are provided, as well as methods of applying such compositions to a keratinous material.
    Type: Grant
    Filed: September 23, 2022
    Date of Patent: August 1, 2023
    Assignee: L'OREAL
    Inventors: Rita Jaky El-Khouri, Jody Ebanks, Rabia Ahmad
  • Halobacillus trueperi TCI66207 and bacterial lysate thereof and use of bactertal lysate
    Patent number: 11712413
    Abstract: A Halobacillus trueperi TCI66207 strain, deposited in the Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures (Accession number DSM 33381). The H. trueperi TCI66207 strain has one or more of the following function: improving skin cell mitochondrion activity, promoting skin cell proliferation, maintaining skin corneum layer completeness, increasing expression of keratin (Keratin14) and/or hyaluronic acid synthase (HAS3) genes and promoting hyaluronic acid production.
    Type: Grant
    Filed: July 20, 2020
    Date of Patent: August 1, 2023
    Assignee: TCI CO., LTD.
    Inventors: Chu-Han Huang, Yung-Hsiang Lin
  • Oral pharmaceutical composition for preventing or treating dry eye syndrome comprising rebamipide or a prodrug thereof
    Patent number: 11712414
    Abstract: Disclosed is an oral pharmaceutical composition for preventing or treating dry eye syndrome, which comprises rebamipide or a prodrug thereof, or a pharmaceutically acceptable salt thereof, as an active ingredient. The compounds can treat dry eye syndrome via oral route, and can be thus employed safely and conveniently compared to conventional eye drops.
    Type: Grant
    Filed: April 17, 2014
    Date of Patent: August 1, 2023
    Assignees: SAMJIN PHARMACEUTICAL CO., LTD., ASTECH. CO., LTD.
    Inventors: Eui Hwan Cho, Sung Ju Choi, Sung Woo Lee, Hee Jong Shin, Jong Bae Yoon, Ki Seok Park, Ho Tae Nam
  • Soft, chewable and orally dissolvable and/or disintegrable products
    Patent number: 11712415
    Abstract: A soft, chewable and orally dissolvable and/or disintegrable product includes a biopolymer-sugar based matrix and botanical powder dispersed throughout the biopolymer-sugar based matrix. The biopolymer-sugar based matrix includes at least one biopolymer, at least one sugar and optional additives. Soft, chewable and orally dissolvable and/or disintegrable product can also include flavor beads.
    Type: Grant
    Filed: February 11, 2021
    Date of Patent: August 1, 2023
    Assignee: Philip Morris USA Inc.
    Inventors: Feng Gao, Shalva Gedevanishvili, Shengsheng Liu, Munmaya K. Mishra, William R. Sweeney, Randall Baren, Qinglin Li, Darin Colassaco, Salem Chouchane
  • Solid oral pharmaceutical compositions for isoxazoline compounds
    Patent number: 11712416
    Abstract: A solid oral pharmaceutical composition for delivery of a pharmaceutically acceptable active ingredient to an animal where the composition comprises an isoxazoline compound, a solvent and an excipient, a process for the manufacture of such solid oral pharmaceutical composition and a method of controlling a parasite infection administering such solid oral pharmaceutical composition.
    Type: Grant
    Filed: March 2, 2021
    Date of Patent: August 1, 2023
    Assignee: Intervet Inc.
    Inventors: Keith Freehauf, Niki Waldron, Jürgen Lutz, Frank Guerino
  • Fast dispersing suspending composition, method of preparation and application thereof
    Patent number: 11712417
    Abstract: Disclosed herein is a fast-dispersing suspending composition which promotes the formation of a suspension for pharmaceutical, food and veterinary products. The composition includes a suspending agent, a diluent, and a glidant, wherein the amounts of these agents are selected to enable the dispersion of the composition and the formation of the suspension. Also disclosed are a method of forming a suspension of a solid dosage form and a method of administering the resulting suspension to a subject.
    Type: Grant
    Filed: June 8, 2022
    Date of Patent: August 1, 2023
    Assignee: AUSON PHARMACEUTICALS INC.
    Inventors: Enxian Lu, Peng Hou, Longlong Feng, Long Wang
  • Chemoembolization agents
    Patent number: 11712418
    Abstract: A chemoembolization therapy, which combines therapeutic effects of peripheral arterial occlusion with the local administration of an anti-cancer agent. A particle or microsphere occludes the arteries providing blood flow to the tumor, resulting in tumor oxygen deprivation. The anti-angiogenic agent is an anti-cancer drug.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: August 1, 2023
    Assignees: BRUIN BIOSCIENCES, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: James Na, David Imagawa, Fabio Tucci, Graham Beaton, Satheesh Ravula
  • Liposome formulations
    Patent number: 11712419
    Abstract: The present invention relates to pharmaceutical formulations comprising an anti angiogenic compound such as a monoclonal antibody or fragment thereof selected from, for example, ranibizumab, which is a vascular endothelial growth factor binder which inhibits the action of VEGF, and a delivery agent selected from a pharmaceutically acceptable liposome. The formulations are useful in the treatment of a variety of angiogenic disorders and diseases in animals and people, and, preferably, in ophthalmic disorders selected from age-related macular degeneration, diabetic macular edema and corneal neovascularization.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: August 1, 2023
    Assignee: OPKO Pharmaceuticals, LLC
    Inventors: Arturo Santos, Phillip Frost
  • Thyroid hormone oral dosage forms and methods of using the same
    Patent number: 11712420
    Abstract: Thyroid hormone oral dosage forms and methods of making and using the thyroid hormone oral dosage forms are disclosed.
    Type: Grant
    Filed: July 20, 2021
    Date of Patent: August 1, 2023
    Assignee: GENUS LIFESCIENCES INC.
    Inventors: Shivaji Phadke, Vaishnavi Parikh
  • Self-actuating articles
    Patent number: 11712421
    Abstract: Self-actuating articles including, for example, self-actuating needles and/or self-actuating biopsy punches, are generally provided. Advantageously, the self-actuating articles described herein may be useful as a general platform for delivery of a wide variety of pharmaceutical drugs that are typically delivered via injection directly into tissue due to degradation in the GI tract. The self-actuating articles described herein may also be used to deliver sensors and/or take biopsies without the need for an endoscopy. In some embodiments, the article comprises a spring (e.g., a coil spring, a beam, a material having particular mechanical recovery characteristics).
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: August 1, 2023
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Carlo Giovanni Traverso, Alex G. Abramson, Ester Caffarel Salvador, Niclas Roxhed, Minsoo Khang, Taylor Bensel, Robert S. Langer
  • Pharmaceutical compositions comprising activated carbon
    Patent number: 11712422
    Abstract: The invention provides a pharmaceutical composition comprising activated carbon particles, for oral administration. The pharmaceutical composition may be for (use in) the treatment of gastrointestinal fistula.
    Type: Grant
    Filed: December 10, 2020
    Date of Patent: August 1, 2023
    Assignee: Ferring B.V.
    Inventor: Soren Halskov
  • Methods and compositions for modifying mucous membranes
    Patent number: 11712423
    Abstract: The present invention relates to methods and compositions for modifying mucous membranes. In particular, the present invention relates to treating diseases associated with mucous membranes by changing the intrinsic chemical composition and/or physical features of a target mucous membrane.
    Type: Grant
    Filed: April 5, 2021
    Date of Patent: August 1, 2023
    Inventors: Nicholas L. Abbott, Christopher J. Murphy
  • Non-therapeutic methods for alleviating or reducing stress symptoms of ruminants
    Patent number: 11712424
    Abstract: The present invention relates to the reduction of stress in ruminants in need thereof.
    Type: Grant
    Filed: January 23, 2019
    Date of Patent: August 1, 2023
    Assignee: DSM IP ASSETS B.V.
    Inventors: Chris McSweeney, Gonzalo Martinez Fernandez, Stuart Edward Denman, Horst Joachim Paul Peter Schirra
  • Immunoregulatory role of 3-OH-kynurenamine and uses thereof
    Patent number: 11712425
    Abstract: Methods are provided for using 3-OH-kynurenamine to treat and prevent an inflammatory or autoimmune disease or disorder or transplant rejection, and for promoting immune tolerance.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: August 1, 2023
    Assignee: ALBERT EINSTEIN COLLEGE OF MEDICINE
    Inventor: Laura Santambrogio
  • Metallo-liothyronine
    Patent number: 11712426
    Abstract: The invention relates to supramolecular metal coordinated liothyronine (triiodothyronine, T3) compositions, methods of preparing such compositions, methods of purifying and formulating supramolecular metal coordinated liothyronine, and methods of treating hypothyroidism and other disease states using such compositions.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: August 1, 2023
    Assignee: SYNTHONICS, INC.
    Inventors: John D. Price, Thomas Piccariello, Michaela E. Mulhare
  • Method for increasing serum adiponectin for treatment and reduction of the risk of cardiovascular, vascular, and related diseases
    Patent number: 11712427
    Abstract: The invention provides methods for reducing the percentage of body fat, increasing the level of adiponectin, and/or treating or reducing the risk of cardiovascular disease (CVD) and coronary heart disease (CHD). Such methods include administering to an animal or human sufficient levels of a compound comprising a tri blend of HPMC (K15, K100, and K200) and myristic fatty acid.
    Type: Grant
    Filed: April 27, 2020
    Date of Patent: August 1, 2023
    Assignee: FIRST FRUITS BUSINESS MINISTRY, LLC
    Inventors: Roger J. Catarino, William D. Kuhne
  • Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
    Patent number: 11712428
    Abstract: In various embodiments, the present invention provides pharmaceutical compositions and methods for treating cardiovascular-related disease.
    Type: Grant
    Filed: November 3, 2020
    Date of Patent: August 1, 2023
    Assignee: Amarin Pharmaceuticals Ireland Limited
    Inventors: Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni, Jonathan Rowe
  • Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
    Patent number: 11712429
    Abstract: In various embodiments, the present invention provides pharmaceutical compositions and methods for treating cardiovascular-related disease.
    Type: Grant
    Filed: November 13, 2020
    Date of Patent: August 1, 2023
    Assignee: Amarin Pharmaceuticals Ireland Limited
    Inventors: Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni, Jonathan Rowe
  • Formulated cannabis oil powder by nanoemulsification, methods of producing and uses thereof
    Patent number: 11712430
    Abstract: The invention discloses particular water-dispersible solid formulation of a cannabinoid or a cannabis extract, wherein they are present in the form of a nanoemulsion, and upon dispersion in water said formulation produces nanoparticles (droplets of a submicron size) with an average size of up to about 500 nm. The present disclosure further relates to methods of making thereof, as well as therapeutic applications in humans for treating disorders and broader application for a range of medical conditions.
    Type: Grant
    Filed: March 11, 2019
    Date of Patent: August 1, 2023
    Assignee: Karnak Technologies, LLC
    Inventors: Shlomo Magdassi, Liraz Larush, Rafael Ezra
  • Compositions comprising cannabinoids and methods of use
    Patent number: 11712431
    Abstract: The present disclosure is related to the use of compositions and their use in reducing and treating pain.
    Type: Grant
    Filed: December 19, 2022
    Date of Patent: August 1, 2023
    Assignee: Schedule 1 Therapeutics, Inc.
    Inventor: George D. Pappas
  • Method of treating cancer with an elevated glycogen content
    Patent number: 11712432
    Abstract: A method of treating cancer is provided. The method includes administering to a subject in need thereof an effective amount of a compound selected from the group consisting of a glycogen phosphorylase inhibitor, a glycogen synthase inhibitor, a glycogen degradation molecule, an anti-sense oligonucleotide that down-regulates glycogen synthesis, and combinations thereof, where the cancer includes elevated levels of glycogen.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: August 1, 2023
    Assignee: University of Kentucky Research Foundation
    Inventors: Matthew S. Gentry, Ramon C. Sun, Lyndsay EA Young
  • Compositions comprising PKM2 modulators and methods of treatment using the same
    Patent number: 11712433
    Abstract: A compound of Structure (I): or a pharmaceutically acceptable salt thereof, alone or in combination with a second therapeutic agent, as well as methods of treating a PKM2-mediated disease or disorder using the same are provided herein.
    Type: Grant
    Filed: March 20, 2020
    Date of Patent: August 1, 2023
    Assignee: Sumitomo Pharma Oncology, Inc.
    Inventors: Steven L. Warner, David J. Bearss, Jason Marc Foulks
  • Compound having anti-cancer effect, and preparation method therefor and use thereof
    Patent number: 11712434
    Abstract: The present invention provides a compound of the formula I, a process for its preparation and the use of a medicament for the treatment of cancer. The compound of the present invention has an inhibitory effect on various cancer cells and can be biologically converted into the active drug Linifanib in vitro (in plasma) to inhibit the proliferation of tumor cells, especially liver cancer cells, at a lower dose.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: August 1, 2023
    Assignee: 3D MEDICINES (BEIJING) CO., LTD.
    Inventors: John Gong, Yihui Lin, Fengqing Li, Fangqiang Tang
  • Mebendazole prodrugs with enhanced solubility and oral bioavailability
    Patent number: 11712435
    Abstract: Prodrugs of mebendazole and methods for their use in treating a disease, disorder, or disorder, including cancer, are disclosed.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: August 1, 2023
    Assignees: THE JOHNS HOPKINS UNIVERSITY, INSTITUTE OF ORGANIC CHEMISTRY & BIOCHEMISTRY AS CR V.V.I.
    Inventors: Barbara Slusher, Rana Rais, Gregory Riggins, Pavel Majer, Tomas Tichy, Jan Vavra, Andrej Jancarik, Lukas Tenora