Abstract: A tissue-filling composition comprises an injectable material having the properties of a Bingham plastic. The tissue-filling composition is a solid which partially liquefies as it is injected through a needle or cannula into solid tissue. The tissue-filling composition may be a poly(vinyl alcohol) produced from an aqueous solution which is subjected to a single freeze-thaw cycle under conditions which cause the poly(vinyl alcohol) to have the properties of a Bingham plastic.

Abstract: The present disclosure relates to methods of preparing protein hydrogels and to protein hydrogels which may, for example, be prepared from such methods. The methods comprise denaturing a protein in an aqueous environment to produce an aqueous composition comprising overlapping polypeptide chains; crosslinking the polypeptide chains to produce a denatured protein hydrogel comprising a crosslinked network of entangled polypeptide chains; and optionally at least partially renaturing the denatured protein hydrogel.

Abstract: The present invention relates to a method for the antibacterial treatment of a solid surface comprising the steps of: a) activation of said surface by means of oxygen plasma; b) deposition from the vapor phase of a silane or siloxane having at least one fluorocarburic terminal group. A method is also provided for the antibacterial treatment of a solid surface comprising the step of functionalizing said surface with nanoparticles of gamma-Fe2O3.

Abstract: A multicompartment conductive collagen scaffold composite, comprising a scaffold comprising collagen and an electrically conductive material, optionally wherein the electrically conductive material comprises electrically conductive particles, and further comprising longitudinally aligned pores, and methods of making and using the same.

Abstract: A method for preventing surgical adhesion between surfaces that are to be prevented uses a blood product having fibrin. The blood product can be a singled layered blood product having components from plasma, components added to initiate a coagulation process, and components created during the coagulation process. The products and methods can be used for preventing surgical adhesion, for stopping or reducing bleeding in an open surgical wound, and for treating surgical wounds.

Abstract: A method of making a biomedical implant comprising the steps of contacting a biomedical implant having a surface comprising titanium with an acidic solution comprising a titanium precursor capable of hydrolysis to titanium for a time sufficient to epitaxially grow titania nanorods on the surface. Preferably, the titanium precursor is selected from the group consisting of titanium butoxide, TTIP and titanium tetrachloride. Carrying out the method provides a biomedical implant having a surface having nanorods comprising at least 50% titania extending therefrom, wherein the nanorods terminate in a substantially conical tip, wherein the nanorods have a density on the implant of at least 10 nanorods/um2.

Abstract: A biomedical implant having a surface having nanorods comprising at least 50% titania extending therefrom, wherein the nanorods are substantially needle-like having an average diameter of less than 50 nm, wherein the nanorods have an areal density of at least 25 nanorods/um2, preferably obtained by contacting a biomedical implant having a surface comprising titanium with an acidic solution comprising ethylene glycol and a titania precursor capable of hydrolysis to titania for a time sufficient to epitaxially grow titania nanorods on the surface.

Abstract: A breast pump relating to the technical filed of breast pumps is provided, comprising a base, a breast pump assembly and a ventilation tube. The base includes a housing and a pneumatic pump, and the pneumatic pump is arranged in the housing. The breast pump assembly is used for pumping the milk of the mammary gland, and is detachably connected to the housing. When the breast pump assembly is separated from the housing, the ventilation tube is connected to the pneumatic pump and the breast pump assembly, so that the pneumatic pump forms a negative pressure on the breast pump assembly. The breast pump assembly is connected to the housing when the ventilation tube is disconnected from the pneumatic pump and the breast pump assembly. The base included in the above breast pump assembly is detachably connected to the breast pump assembly.

Abstract: A breast pump is provided, including a milk bowl, and a breast shield detachably connected to the milk bowl, and a main body detachably connected to the milk bowl. A milk storage cavity for storing milk is defined by the milk bowl and the breast shield. The main body includes a housing detachably connected to the milk bowl, and an air pump disposed in the housing and used for generating negative pressure. One of the housing and the milk bowl is provided with a connecting post, another is provided with a connecting groove, and the connecting post and the connecting groove are detachably inserted. One of the housing and the milk bowl is provided with an elastic protrusion, another is provided with a groove corresponding to the elastic protrusion, and when the housing is assembled with the milk bowl, the elastic protrusion is placed in the groove.

Abstract: A breast pump includes a milk bowl, a breast shield, a main body, and a membrane. The breast shield is detachably connected to the milk bowl. A milk storage cavity for storing milk is defined by the breast shield and the milk bowl. The main body is detachably connected to the milk bowl. The breast shield has a flange shaped to fit a breast and a milk pumping channel for receiving a nipple. An air pump for generating negative pressure is provided inside the main body, the milk bowl is air communicated with the negative pressure generated by the air pump and acting on the milk pumping channel to promote lactation. The membrane prevents the milk from reaching the air pump. The milk bowl is provided with a connecting part connected with the membrane, and the connecting part is embedded in the membrane.

Abstract: A breast pump is provided, including a milk bowl, and a breast shield detachably connected to the milk bowl, and a main body detachably connected to the milk bowl. A milk storage cavity for storing milk is defined by the milk bowl and the breast shield. The main body includes a housing detachably connected to the milk bowl, and an air pump disposed in the housing and used for generating negative pressure. The milk bowl is provided with a milk outlet spatially communicating with the milk storage cavity, and the housing is provided with a hole plug engaged to the milk outlet and used for partially sealing or completely sealing the milk outlet when the housing is assembled with the milk bowl.

Abstract: A method of preparing a solution for use during a dialysis, hemodialysis, or Continuous Renal Replacement Therapy (CRRT) treatment of a patient is provided. An antibiotic or other drug is added (48, 50, 52) to a solution and the concentration or dosing of the antiboitic or other drug within the solution is adjusted (72) as required based on a determiniation (64) of serum level of the antibiotic in a blood sample of a patient.

Abstract: A mobile dialysis fluid generation system includes a cargo unit configured to be transported by a vehicle; a cleanroom located inside the cargo unit; water purification equipment; at least one dialysis fluid preparation unit located inside the cleanroom; and at least one area provided outside the cleanroom but inside the cargo unit for storing at least one of a raw material or containers filled with dialysis fluid. The at least one dialysis fluid preparation unit includes at least one concentrate, a mixing device configured to receive purified water from the water purification equipment and to mix the purified water with the at least one concentrate to form dialysis fluid, a tubing set for transfer of the dialysis fluid from the mixing device to a container positioned and arranged to receive the dialysis fluid.

Abstract: A medical fluid container assembling system and method are disclosed. The system includes a coiled catheter pallet for receiving a catheter tip portion of a coiled catheter. The system also includes a coiled catheter preparation unit configured to place the coiled catheter on the coiled catheter pallet in a predetermined posture, and cause the catheter tip portion of the coiled catheter to extend a predetermined length. The system further includes a container body pallet for receiving a container tube of a container body. Additionally, the system includes a container body preparation unit configured to place the container body on the container body pallet in a predetermined posture, and cause the container tube of the container body to extend a predetermined length. The system also includes a container tube expander, a catheter tip gluing device, and an assembling mechanism configured to insert the catheter tip portion into the container tube.

Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that include a filter for removal of waste products from a dialysate. The filter may include multiple layers of one or more filter materials configured to allow dialysate to flow through the multiple layers.

Abstract: The device for blood oxygenation includes a gas exchange chamber with passage openings. One side the chamber is connected in a gas-tight manner with the expansion tank feeding the gas mixture containing oxygen to the chamber, having the inlet opening of gas mixture from the feeding installation. The other side of the chamber is connected in a gas-tight manner with the gas mixture discharging tank, having the outlet opening of gas mixture. The inner part of the chamber has a membrane as a capillary bundle permeable to gas mixture particles and non-permeable to blood particles, ends of which are anchored in the passage openings. The capillary bundle is tensed with a tension force and is parallel to the longitudinal axis of the chamber and to each other, or are arranged spirally. The side wall of the chamber has at least one inlet/outlet opening.

Abstract: A device for binding and separation of at least one component from a body fluid is disclosed. The device may have a proximal end and a distal end. The device may include a housing, an inlet disposed at the proximal end, an outlet, at least one of a sheet and a disc of a first matrix for binding of a first component from the body fluid, and a plurality of beads of a second matrix for binding of a second component from the body fluid. The first matrix may have a porous structure. The first component and the second component may be one of the same and different.

Abstract: A multi-lumen catheter includes a body surrounded by an outer wall; an inner space of the body being divided with a partition, into a plurality of lumens including a first lumen and a second lumen. The second lumen has a second opening plane at its distal end, and the first lumen has a first opening plane at its distal end, the second opening plane being positioned more distally than the first opening plane. The outer wall includes a first outer wall portion defining the first lumen, the first outer wall portion having a first lumen slit notching a portion of a distal end of the first outer wall portion. The body includes a flexible portion having a lower hardness, the flexible portion including a distal end portion of the first outer wall portion, the distal end portion including the first lumen slit first lumen slit.

Abstract: The present invention provides mannose-binding lectin (MBL)-based compositions, and methods of using the MBL-based compositions in the reduction of unintended platelet activation, such as during a medical procedure.

Abstract: Some embodiments are directed to a system 10 for the application of topical negative pressure therapy to a site 18 on the body of a mammal. Some embodiments of the system 10 comprise a piston 22 and cylinder 24 device 12 having a self-contained power source for the generation of a reduced pressure and for aspirating the site 18. Some embodiments of the system 10 comprise a dressing 14 sealably surrounding the site 18 that can be operably connected to the device 12 by a conduit means 16 to apply the reduced pressure to the site 18.

Abstract: A suction tip and tubing aspirator is disclosed and comprises a first lumen having a first open end adapted to be operatively connected to a source of suction, and a second open end adapted to be inserted into a site from which tissue or debris is to be aspirationally removed, a second lumen integrally connected to the first lumen, and a stylus movably disposed within the second lumen between retracted and extended positions such that when the stylus is moved from the retracted position to the extended position, a distal end portion of the stylus will protrude outwardly from the second end of the first lumen so as to remove any tissue or debris which has clogged, blocked, or occluded the second open end of said first lumen.

Abstract: A bioresorbable device for implantation in the body of a patient for administering fluid and/or negative pressure to a treatment site. The device includes a bioresorbable resilient truss for holding two tissue surfaces spaced apart. The truss has two flexible elongate wall members wound in a manner to define a channel, the two elongate wall members intersecting each other periodically at a plurality of cross-over nodes. The truss also includes at least two flexible elongate bracing members, each bracing member being mechanically linked to the two elongate wall members at a plurality of the cross-over nodes.

Abstract: A liquid container (30) for an anal irrigation system, where the liquid container comprises a top part (33) and a bottom wall (32), at least one side wall (34) connecting the bottom wall (32) with the top part (33) forming a cavity for storage of liquid, where the liquid container (30) comprises a filling spout (41) located in the at least one side wall (34) such that the filling spout is closer to the top part than the bottom part, the filling spout (41) having a periphery, and where the liquid container further (30) comprises a handle (44), wherein in that the handle (44) is rotatable around the periphery of the filling spout (41), the liquid container (30) being configured for allowing the user to lift and hold the container in different positions.

Abstract: A portable bowel irrigating system for irrigating the bowels of a user with a removably attachable and replaceable pump cartridge allowing for moving parts of the pump mechanism to be substituted and for a high standard of cleanliness. The system includes a base unit, a liquid container, the pump cartridge, tubing, and an anal probe. Also disclosed is a method of irrigating the bowels of a user.

Abstract: A recharging and medication storage hub for a re-usable drug-delivery device is provided. According to some embodiments, the hub comprises a housing defining a port sized to receive at least part of the re-usable drug-delivery device, a charging station disposed on the housing configured to charge a rechargeable power source mounted on the drug-delivery device, and a medication storage chamber disposed in alignment with the port, the storage chamber configured to store a single-use medication cartridge. When at least part of the drug-delivery device is inserted through the port and into the medication storage chamber, a coupling mechanism is configured to releasably couple with and withdraw the medication cartridge from the medication storage chamber. In some embodiments, the hub may further comprise a temperature-changing device configured to control an interior temperature of the medication storage chamber.

Abstract: A liquid medicine administration device includes: a needle unit configured to be inserted into and placed on a living body; a liquid medicine supply device provided separately from the needle unit and configured to deliver a liquid medicine filled inside from a distal portion; a tube configured to allow the liquid medicine to flow, the tube having a distal end connected to the needle unit; and a connector to which are attachable both (i) the liquid medicine supply device, and (ii) a priming solution delivery device configured to deliver a priming solution filled inside from a distal portion. The connector includes: a hollow needle having a needle hole that is formed inside the hollow needle and that communicates with the tube, the hollow needle protruding toward the liquid medicine supply device or the priming solution delivery device, and a valve body that is disposed distal to the hollow needle.

Abstract: A liquid medicine administration device includes: a needle unit configured to be inserted into and placed on a living body; a liquid medicine supply device provided separately from the needle unit and configured to deliver a liquid medicine filled inside from a distal portion; a tube configured to allow the liquid medicine to flow, the tube having a distal end connected to the needle unit; and a connector to which the liquid medicine supply device is attached, the connector being located at a proximal end of the tube. The connector includes: a valve body that has a disk shape and that opens during delivery of the liquid medicine to allow the liquid medicine supply device to communicate with the tube, and a valve seat that is annular and provided on a tube side with respect to the valve body, the valve seat protruding toward and contacting the valve body.

Abstract: Embodiments of the current disclosure are directed toward systems, devices and methods for diabetes management. In particular, the present disclosure relates to systems, devices and methods for dispensing insulin to a patient using a miniaturized and portable patch pump.

Abstract: A body-worn medication delivery pump having a patch form factor is provided that includes a controller and an integrated plethysmographic module that employs a photoplethysmographic multi-chip package disposed in a skin contact element designed to maintain contact with a wearer's skin during motion, reduce contact pressure inflammation during prolonged contact, reduce crosstalk and ingress of stray light, such that the controller of the pump programmed is programmed to adjust its medication delivery algorithms responsive to outputs of the plethysmographic module.

Abstract: A venous needle monitoring device. An apparatus and system for monitoring for the presence of a needle or cannula to determine if it becomes dislodged from a patient. A venous needle monitoring device comprising: a wearable device; at least one temperature sensor; at least one heart rate sensor; a controller with a transmitter. The at least one temperature sensor and at least one heart rate sensor are disposed on the wearable device. The controller and transmitter are located within the wearable device. The at least one temperature sensor and at least one heart rate sensor are in communication with the controller. The controller generates an alarm signal when a threshold value is reached based upon a temperature value measured by the at least one temperature sensor and a heart rate value measured by the at least one heart rate sensor. Wherein the transmitter is suitably disposed for transmitting the alarm signal to one or more associated medical devices.

Abstract: Devices and methods are provided to improve accuracy of occlusion detection based on measured data in a fluid delivery device by using dead band normalization of loaded measured data to unloaded measured data. The loaded measured data and unloaded measured data are obtained during the same fluid movement operation or stroke of the fluid delivery device. The dead band normalization can be performed during an aspiration operation or a dispensing operation. An interface in the fluid delivery device that is close to the fluid driving mechanism and that can at least temporarily move under control but without moving fluid can be used to identify when to generate unloaded measured data during a fluid movement operation for dead band normalization of loaded measured data measured during that fluid movement operation.

Abstract: Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, a controller module, and optionally a single point glucose monitor are provided. Integration may be manual, semi-automated and/or fully automated.

Abstract: The autoinjector includes a housing extending along longitudinal axis (A) and configured to receive a medical container having a barrel defining a reservoir for containing a medical product, said barrel having a distal end provided with an injection needle and an opened proximal end. A power pack arranged inside the housing for expelling the medical product from the medical container. The power pack includes a plunger rod configured to extend through the opened proximal end of the barrel for pushing a stopper arranged inside the barrel. The plunger rod is axially movable between an initial position and an injection end position distally located with respect to the initial position. Resilient adjustment means are arranged between the plunger rod and the barrel for compensating clearances between the plunger rod and the barrel.

Abstract: A sub-assembly for a medicament delivery device, the sub-assembly having a housing extending along a longitudinal axis from a proximal end to a distal end; a cap releasably attached to the proximal end of the housing; wherein one of the cap and the housing has a user-visible surface extending in a circumferential direction relative to the axis, the surface having a cut-out; wherein the other one of the cap and the housing has a protrusion in the cut-out; and wherein the cut-out defines a user-visible labyrinth which the protrusion must follow during use in order for the cap to be detached from the housing.

Abstract: Filter needle comprising a hub having a proximal end arranged for removable connection to a syringe body, and having a distal end in which a needle is mounted, the hub provided with a channel between the proximal end and the distal end, for when the syringe body is connected, establishing a fluid connection between the syringe body and the needle, wherein a filter unit is mounted in the channel of the hub.

Abstract: Methods and associated structures for translating a syringe stopper though a lubricant free tube, such as an insertion tube, syringe barrel or cartridge tube, during the assembly and/or use of the syringe or auto-injector. The stopper in a non-compressed state includes a proximal end, a plunger rod engaging cavity, and a sealing region having a length spaced from the proximal end by a sealing location length. The sealing region includes at least one rib having at least one microgroove within a polymer barrier, the at least one microgroove having an initial width. By the disclosed methods and structures, a translation force biased towards the outer diameter of the stopper is applied to the stopper using force concentrators. The translation force with force concentrators is sufficient to translate the stopper though the tube in a compressed state with a reduction of increase in the initial width of the at least one microgroove when compared to not using force concentrators.

Abstract: Coverings for syringe plunger tips, as well as syringes and syringe components including such coverings, are disclosed. A material of the covering may have at least one different material property than a material of the plunger tip. The coverings may provide a reduced coefficient of friction between the covering and a surface of the syringe relative to the coefficient of friction between the plunger tip and the syringe surface. The coverings may also isolate a substance loaded in the syringe from the plunger tip. The coverings may include a locking member to lock the covering over the plunger tip. Methods for manufacturing a syringe assembly including such coverings are also disclosed.

Abstract: A drug delivery device comprising electronic circuitry comprising sensor means adapted to capture a property value related to the dose amount of drug expelled from the reservoir by the expelling means a during an expelling event, storage means adapted to store a plurality of property values to create a data log, and transmission means for wireless transfer of the data log to an external device at a low speed. The transmission means is adapted to listen for and receive a scan request packet whereby the transmission means is operated to wireless transfer of the data log to an external device at a higher speed.

Abstract: The cap includes a housing extending along a longitudinal axis A, the housing having a distal end and an opposite proximal end configured to be removably attached to the body of the autoinjector. A retainer is arranged inside the housing and is axially movable with respect to said housing, the retainer including an inner cavity for receiving the needle shield, a clamping member configured to remove the needle shield from the medical container, an opened distal end configured to provide access to a distal end of the needle shield, and a proximal abutment surface configured to abut against the medical container. A plug is arranged at the distal end of the housing, the plug including a sealing portion configured for closing the distal end of the housing and at least one anti-rattling member arranged at a proximal side of the sealing portion for abutting against the retainer and move the retainer in the proximal direction.

Abstract: A machine for the preparation of a medical product with a worktop includes a hole for introducing syringes such that the injection points thereof are positioned for filling by the machine and a device for loading syringes. The device includes a fixed portion and a moveable portion, it being possible for the moveable portion to slide with respect to the fixed portion. The fixed portion includes housings for syringes that extend in a direction that is not parallel to that of the movement of the moveable portion. The moveable portion includes housings for syringes that extend in the direction of movement of the moveable portion. Two points of the movement of the moveable portion define a working position where the housings are aligned such that each pair of housings of the fixed portion and moveable portion receive the same syringe. The housings are misaligned in the loading position.

Abstract: A drug delivery device includes a housing element, a protection member, a movable member, wherein the drug delivery device has an initial state, in which (i) the protection member is in an extended position to cover the drug delivery element, (ii) the protection member is movable in a proximal direction from the extended position into a retracted position in order to expose the drug delivery element, and (iii) the protection member is coupled to the movable member in distal direction and proximal direction such that an axial movement of the protection member in both, the distal and proximal direction, results in an axial movement of the movable member in the same direction. The drug delivery device is configured such that, starting from the initial state, movement of the protection member in proximal direction initiates a rotation of the movable member relative to the protection member by a predetermined angle.

Abstract: A sub-assembly for a medicament delivery device cassette unit, the sub-assembly having a body extending along a longitudinal axis from a proximal end to a distal end; a delivery member guard coaxially attached to the body and being axially movable relative to the body along the longitudinal axis; a latch adjacent to the delivery member guard and axially movable relative to the body; and a lock member attached to the body; the lock member is movable relative to the latch between a locked position and an unlocked position; the lock member has a distally directed surface facing a proximally directed surface of the latch in the locked position; and wherein the distally directed surface of the lock member is further apart from the proximally directed surface of the latch in the unlocked position than in the locked position.

Abstract: A medication delivery device is provided and comprises a housing, a plunger within the said housing, a plunger hook, and a button, the button connects to a safety sleeve, disengaging safety sleeve from the plunger hook, thereafter the button engages with the plunger hook to push release the plunger held under spring pressure. The device further comprises a shield lock member to connect a pre-filled syringe (PFS) holder and a needle shield together. The shield lock member is activated after the dose is delivered.

Abstract: A slope needle includes a needle base having a predetermined length. The needle base accommodates a cannula therein with a portion of the cannula protruded to an outside; and a slope hub configured to be coupled to a syringe. The slope hub is extended from the needle base. The needle base includes a needle base bevel formed at an end of the needle base from which the cannula protrudes.

Abstract: An activation assisting assembly for a medicament delivery device is provided where a first part has a first tubular portion extending along a longitudinal axis (L); wherein the first tubular portion comprises a cavity extending along the longitudinal axis (L) between a first end and a second end; wherein the second end of the cavity has an opening; a second part having a second tubular portion axially aligned with the first tubular portion, and being axially movable relative to the first tubular portion; wherein the second tubular portion has a recess facing towards the opening of the cavity of the first tubular portion; a pin movably connected to the second tubular portion; wherein the pin has an elongated body extending between a first end, distal from the recess of the second tubular portion, and a second end.

Abstract: A fluid delivery system and a fluid conduit assembly suitable for use with the system are disclosed herein. The system includes a fluid infusion pump and a fluid conduit assembly coupled to the pump to deliver medication fluid to a user. The fluid conduit assembly includes a structure defining a flow path for the medication fluid, and a gas trapping filter coupled to the structure and positioned in the flow path. The gas trapping filter functions to filter particulates from the medication fluid and retain gas bubbles from the medication fluid.

Abstract: An infusion liquid heating and flow-velocity-monitoring system for clinical use is provided. The system includes a dynamic heating module, a measurement and analysis module for average velocity in infusion tubes, a velocity adjustment module, an alarming and automatic clipping module, a mobile-phone-computer remote monitoring module, an operable shared module, and a micro control module. A method of determining average velocity on a cross section of a tube according to a solution to Fourier series in a dynamic thermal dispersion equation of a steady flow in the tube is provided. Moreover, functions including monitoring infusion rate, automatic heating, monitoring whether infusion fluid in the infusion tube is empty, and automatic clipping and closing of the tube for preventing blood backflow, etc. are achieved. Lastly, specific applications developed which is connected with mobile phones by 5G network, Bluetooth and WIFI are used to display status of the infusion fluid.

Abstract: A photo-resist (21) is applied in a pattern or vertical columns having the dimensions of holes or pores of the aperture plate to be produced. This mask pattern provides the apertures which define the aerosol particle size, having up to 2500 holes per square mm. There is electro-deposition of metal (22) into the spaces around the columns (21). There is further application of a second photo-resist mask (25) of much larger (wider and taller) columns, encompassing the area of a number of first columns (21). The hole diameter in the second plating layer is chosen according to a desired flow rate.

Abstract: A smart vaporizer that uses a vibrating mesh nebulizer with water based liquids that tracks the type of liquid, dosage inhaled, time, and user then transmits that information to smart devices such as smart phones and smart watches which then transmits back to the vaporizer additional data related to user weight, body fat, heart rate, blood pressure, temperature, movement, sleep, blood sugar, and medication usage to determine when metered amounts of said liquid may be inhaled by a user.

Abstract: The present invention relates to an insufflator with a novel type of input processing for the setpoint value of the pressure in the body cavity. The new device makes it possible to predefine the pressure in the body cavity as the set pressure when there is sufficient expansion and to apply this pressure to the previous control in order to work as gently as possible on the patient.