Abstract: Intravascular blood pumps and methods of use. The fluid system can be configured to pump fluid to a sheath portion and a catheter portion of a catheter blood pump. The fluid system can include a console having one or more pumps for providing fluid flow to the catheter blood pump. A return waste line may return from the catheter blood pump. A removable fluid cassette that directs fluid flow may be coupled to the console. The blood pump may include a pump portion that includes a collapsible blood conduit defining a blood flow lumen between an inflow and an outflow. The pump portion may include a distal collapsible impeller axially spaced from a proximal collapsible impeller, at least a portion of each of the distal and proximal collapsible impellers disposed between the inflow and the outflow.

Abstract: An implantable pump is configured to be implanted in series with blood flow from a heart. The pump includes a frame configured to be implanted within the natural blood flow of the heart such as a ventricular outflow tract an outlet valve of the heart, and a central axle configured to be affixed within the frame parallel to the blood flow. The pump also includes a rotor attached to the central axle and configured to rotate in order to pump blood, and at least two electromagnetic coils configured to be energized in order to cause the rotor to rotate.

Abstract: An inlet tube of a circulatory support device includes a first end configured to receive incoming blood and a second end coupled to a first end of a blood pump. A lumen extends from the first end to the second end, and a spiral feature is disposed within the lumen and configured to support a spiral flow of the incoming blood.

Abstract: A rotary machine is provided which may include a rotor and a stator within a housing. The stator may be for generating a rotating magnetic field for applying a torque to the rotor. A commutator circuit may provide a plurality of phase voltages to the stator, and a controller may adjust the plurality of phase voltages provided by the commutator circuit to modify an attractive force of the stator on the rotor to move the rotor in an axial direction.

Abstract: The disclosure relates to devices and methods for the treatment of edema, which devices use a restrictor for flow compensation. Devices and methods of the invention further use a flow-restrictor in the circulatory system, upstream of an intravascular pump, to balance pressure changes induced by the pump and to compensate for downstream flow. The device may be provided as an indwelling, intravascular catheter with a mechanical pump such as an impeller and a selectively deployable restrictor such as an inflatable balloon. Congestive heart failure or edema is treated by \ operating the pump in an innominate vein and using the restrictor for flow compensation, to restrict the upstream flow and thus amplify or maintain pressure reduction at the lymphatic outlet.

Abstract: An alignment garment for holding an external coil in a predetermined location. The alignment garment may comprise an attachment mechanism for holding the external coil in the predetermined location. The alignment garment may also have a plurality of straps with a first strap in the plurality of straps being secured to the attachment mechanism and a second strap of the plurality of straps being secured to the attachment mechanism.

Abstract: The present disclosure relates to intracorporeal gas exchange systems and methods in conditions associated with hypoxia and hypercarbia. The present disclosure envisages an intracorporeal oxygenation system comprising a blood oxygenator having a blood compartment and a gas compartment. The blood and gas compartments are separated by a gas permeable barrier so as to allow exchange of carbon dioxide in blood in the blood compartment with oxygen in the gas compartment. The system comprises a catheter device for insertion in a blood vessel of human comprising an interior portion and an exterior portion wherein the interior portion (100a) comprises an annular housing, a plurality of capillary conduit, a pumping device, an air sensing device, a blood sensor and a collar. The present disclosure also relates to a method of oxygenating a deoxygenated blood in a human and also to a method for treating a human suffering from hypoxia or hypercarbia.

Abstract: A neuromodulation apparatus and method of using the same. The neuromodulation apparatus has a plurality of active electrodes electrically isolated from each other and arranged in at least one electrodes array, at least one reference electrode, a pulse generator electrically connected to each active electrode of the plurality of active electrodes and configured to selectively transmit electric pulses to each of the plurality of active electrodes and a control unit coupled to the electrical pulse generator and adapted to measure a resistance and/or a current-voltage characteristic between each active electrode of the plurality of active electrodes and the at least one reference electrode.

Abstract: Disclosed herein are wound-healing systems and methods thereof. A wound-healing system can include a wound dressing, a catheter-stabilization device, and an electrical-stimulation means for applying electrical stimulation to heal or protect at least a wound associated with a percutaneous insertion site of a patient. The wound dressing can be configured as an electrode for placement around the wound. The catheter-stabilization device can include an anchor pad and a retainer coupled to the anchor pad. The anchor pad can be configured to adhere to skin of the patient proximate the insertion site. The retainer can be configured to stabilize a catheter assembly while a catheter tube of the catheter assembly is disposed in the insertion site. The electrical-stimulation means can include an electrical power source and an external circuit between the catheter-stabilization device and the wound dressing for applying the electrical stimulation.

Abstract: The present disclosure relates to a mask pad having EMS electrode pads. Each electrode of the EMS electrode pad may be provided to correspond to the shape and size of the divided area according to the virtual line. The mask pad according to the present invention may minimize the edge current effect by the shape of the electrode to which electric energy is applied. In addition, energy transfer efficiency may be improved by capacitive coupling between the electrode and the skin. In addition, due to the coating of the electrode, a rate of contact with an affected part may be increased so that current may be applied evenly to each part.

Abstract: Alternating electric fields (e.g., TTFields) may be applied to a subject's body using electrode assemblies, each of which includes a plurality of graphite sheets (or sheets of another conductive anisotropic material) that are positioned adjacent to, but not touching, each other. One or more electrode elements are disposed in electrical contact with each of the graphite sheets. Strips of electrically insulating and thermally conductive material are disposed between the graphite sheets, and these strips are positioned in thermal contact with the adjacent graphite sheets. The graphite sheets facilitate the passive spreading of heat within the confines of any given sheet. And the strips of material allow the passive spreading of heat to continue beyond the confines of any given sheet without compromising inter-sheet electrical isolation.

Abstract: A biostimulator transport system, such as a biostimulator delivery system, is described. The biostimulator transport system includes a flexible tether extending through a tether support to a tether bight. The tether bight loops through an attachment feature of a biostimulator to connect the biostimulator to the biostimulator transport system. Tether legs extend from the tether bight to a handle of the biostimulator transport system. The handle includes a housing and a knob, and the tether legs attach to the housing and the knob. A tether leg can be disconnected from the housing and the knob can be removed to pull the tether out of the attachment feature and release the biostimulator from the biostimulator transport system. Other embodiments are also described and claimed.

Abstract: A cosmetic method for treating a skin of a person is presented, the method comprises inserting one or more needles to one or more depths into the skin of the person such that at least a tip of at least one needle of the one or more needles is deployed within a muscle layer of the person's skin; applying a negative DC voltage to the one or more needles, while a skin of the person is in contact with a positive electrode to form one or more closed circuits of DC current through the person's body; and providing the DC current for a pre-selected amount of time to damage and/or ablate muscles and/or muscle nerve cells in the muscle layer; thereby providing a skin treatment comprising reducing and/or smoothing wrinkles from the person's skin.

Abstract: A method and a system for skin treatment are presented. A muscle stimulating element is configured to provide muscle stimulation to a muscle layer located below the skin tissue, a handheld applicator is configured to be placed in vicinity of the skin tissue to deliver a muscle stimulation flow from said muscle stimulating element to cause selective contraction and expansion of one or more muscles in the muscle layer located below the skin tissue; and a control board is configured and operable to activate the muscle stimulating element according to one or more activation patterns adapted to provide said muscle stimulation flow to thereby provide one or more treatments to the skin tissue.

Abstract: Tumor treating fields (TTFields) can be delivered by implanting a plurality of sets of implantable electrode elements within a person's body. Temperature sensors positioned to measure the temperature at the electrode elements are also implanted, along with a circuit that collects temperature measurements from the temperature sensors. In some embodiments, an AC voltage generator configured to apply an AC voltage across the plurality of sets of electrode elements is also implanted within the person's body.

Abstract: A neuromodulation system, device, and method are disclosed. In an embodiment, a neuromodulation system includes a processor, a signal generator, a first electrode, and a second electrode. The processor in cooperation with the signal generator, the first electrode, and the second electrode are configured to deliver a transcutaneous stimulation to a mammal. The transcutaneous stimulation is configured by the processor for inducing voluntary movement in the mammal. The first electrode is positioned transcutaneously on a spinal cord and/or spinal cord dorsal roots of the mammal. Additionally, the second electrode is placed transcutaneously on or over at least one of the spinal cord and/or the spinal cord dorsal roots, a muscle, a nerve, or on or near a target end organ or bodily structure of the mammal. The second electrode is in communication with the first electrode through a hardwire or wireless connection.

Abstract: A method of treating acute respiratory distress syndrome (ARDS) in a subject by applying an alternating electric field (AEF) to a region of the subject's torso. The ARDS may be caused by sepsis, viral infection, bacterial infection, near-drowning, chemical inhalation, acute pancreatitis, and chest injury. The viral infection may be COVID-19 or long covid. The ARDS may be identified using the Berlin Definition.

Abstract: A balloon type retinal stimulation device includes: a substrate unit having an insertion portion provided to be inserted into an eyeball; and a stimulation unit that is provided at one or both of one and the other surfaces of the substrate unit. The insertion portion is provided to be expandable and contractible as a fluid is injected into and discharged from an inside of the injection portion. When the insertion portion expands, one surface of the insertion portion is deformed to match a shape of the retina such that the stimulation unit is brought into close contact with the retina on which an image is formed, and the other surface of the insertion portion comes into close contact with an inner surface of the eyeball that is not a region of retina on which an image is formed, to support the insertion portion that is in contact with the region of retina on which an image is formed.

Abstract: An implantable device configured for implantation in a body of subject. The device includes: a flexible body and at least one stimulator unit attached to the flexible body, wherein the at least one stimulator unit includes a plurality of electric components encapsulated in a hermetically sealed enclosure, a receiving antenna, and at least one electric conductor in electrical connection with the plurality of electric components.

Abstract: Systems and methods are provided for neurostimulation timed relative to respiratory activity. Neurostimulation may be delivered to the spinal cord, the vagus nerve, and/or branches of the vagus nerve to provide therapeutic outcomes by controlling or adjusting stimulation based on pulmonary activity. In particular, the systems and methods use a detecting device to detect respiratory activity over time. Specific points in the respiratory signal are identified where central autonomic nuclei may be more receptive to afferent input and a stimulator is instructed to provide neurostimulation to at least one auricular branch of a vagus nerve, or to a cervical branch of the vagus nerve, or to a spinal cord of the subject. In this regard, the neurostimulation is advantageously correlated to the detected respiratory activity providing improved therapeutic outcomes.

Abstract: Stimulation for treating sensory deficits in patients with spinal cord injuries and/or peripheral polyneuropathy, and associated systems and methods. A representative method includes addressing the patient's somatosensory dysfunction, resulting from neuropathy and/or spinal cord injury, by directing an electrical therapy signal to the patient's spinal cord region, the therapy signal having a frequency in a frequency range from 200 Hz to 100 kHz.

Abstract: Methods and apparatuses for setting a therapeutic dose of a neuromodulator implanted into a patient. The therapeutic dose typically includes a therapeutic dose duration including a ramp-up time to reach a peak modulation voltage and a sustained peak modulation time during which the voltage is sustained at the peak modulation voltage. The methods and apparatuses may use a testing ramp to identify a peak modulation voltage that is patient-specific and provides a maximized therapeutic effect while remaining comfortably tolerable by the patient during the application of energy by the neuromodulator.

Abstract: Methods and systems for improving headache pain by using feedback mechanisms are provided.

Abstract: A computer implemented system and method facilitates a cycle of generation, sharing, and refinement of volumes related to stimulation of anatomical tissue, such as brain or spinal cord stimulation. Such volumes can include target stimulation volumes, side effect volumes, and volumes of estimated activation. A computer system and method also facilitates analysis of groups of volumes, including analysis of differences and/or commonalities between different groups of volumes.

Abstract: Example devices and techniques for improving signal quality of a sensed evoked response signal include processing circuitry communicatively coupled to stimulation generation circuitry and sensing circuitry. The processing circuitry is configured to control the stimulation generation circuitry to generate a stimulation signal and receive from the sensing circuitry the sensed evoked response signal. The processing circuitry is configured to determine that a characteristic value of at least one of the artifact or the sensed evoked response signal meets a threshold and automatically change, based on the determination that the characteristic value of the at least one of an artifact in the sensed evoked response signal or the sensed evoked response signal meets the threshold, at least one sensing parameter.

Abstract: System and methods are provided herein and include a HIS electrode configured to be located proximate to a HIS bundle and to at least partially define a HIS sensing vector. They system includes memory to store program instructions and cardiac activity (CA) signals for a series of beats utilizing a candidate sensing configuration. The candidate sensing configuration is defined by i) the HIS sensing vector and ii) a sensing channel that utilizes sensing circuitry configured to operate based on one or more sensing settings to detect near field and far field activity. The system includes one or more processors that, when executing the program instructions, are configured to analyze the CA signals to obtain an atrial (A) feature of interest (FOI) and a ventricular (V) FOI for the corresponding beats within the series of beats and identify a V-A FOI relation between the A FOIs and the V FOIs across the series of beats.

Abstract: A method of cardiac signal processing including: receiving measurements from at least two electrodes positioned within the heart; determining, using the measurements, relative positioning of the at least two electrodes relative to each other; evaluating suitability of the relative positioning of the at least two electrodes for measurement of cardiac activity to determine which cardiac cycles should receive cardiac contractility modulation stimulation.

Abstract: An example system includes telemetry circuitry configured for communication between a medical device and an external device associated with the medical device and processing circuitry. The processing circuitry is configured to receive, with the telemetry circuitry, an advertisement from the medical device. The advertisement includes connection parameters for a potential communication session with the medical device and an indication that the medical device is connected by an established communication session between the medical device and a connected device. The processing circuitry is further configured to identify the connected device using the indication of the advertisement, initiate a communication session between the telemetry circuitry and the connected device, and output, with the telemetry circuitry and using the communication session between the telemetry circuitry and the connected device, a request for information from the medical device.

Abstract: Systems, apparatus, methods and non-transitory computer readable media facilitating telemetry data communication security between an implantable device and an external clinician device are provided. An implantable device can include a security component configured to generate security information based on reception of a clinician telemetry session request from the clinician device via a first telemetry communication protocol. The security information can include a session identifier and a first session key, and the clinician telemetry session request can include a clinician device identifier associated with the clinician device.

Abstract: A method (100) for using an automated external defibrillator (AED) (310), the method comprising: receiving (120), during an active CPR protocol, a signal indicative of motion or lack of motion of the individual; analyzing (130), by the controller, the received signal to determine whether the individual is undergoing motion; providing (140) a direction to begin or continue chest compressions if the controller determines from the received signal that the individual is not undergoing motion; analyzing (150), by the controller, a received ECG signal to determine whether the individual could benefit from a shock delivered from the AED; interrupting (160) the active CPR protocol, if the individual is not undergoing motion and if the individual could benefit from a shock delivered from the AED; and delivering (170) a shock to the individual.

Abstract: In embodiments, a WCD system includes electrodes with which it senses an ECG signal of the patient. A processor may detect sequential peaks within the ECG signal, measure durations of time intervals between the peaks, including between non-sequential peaks, and identify a representative duration that best meets a plausibility criterion. The plausibility criterion may be that the representative duration is the one that occurs the most often, i.e. is the mode. Then a heart rate can be computed from a duration indicated by the representative duration and, if the heart rate meets a shock condition, the WCD system may deliver a shock to the patient. An advantage can be that the representative duration can be close to a good R-R interval measurement of a patient, notwithstanding noise in the ECG signal that is in the shape of peaks.

Abstract: A stimulation device and a method to coordinately stimulate two separate nerves in a human or animal body for activating a target tissue in the human or animal body comprises a first coil unit (91) configured to be positioned at the human or animal body to stimulate a first nerve of the two separate nerves, a second coil unit (92) configured to be positioned at the human or animal body to stimulate a second nerve of the two separate nerves; and a bracket structure (93) coupled to the first coil unit (91) and the second coil unit (92). The bracket structure (93) is adjustable such that positions and orientations of the first coil unit (91) and of the second coil unit (92) relative to each other are adaptable to a target configuration in which the first coil unit (91) and the second coil unit (92) are distinctly positioned at the human or animal body such that the first nerve can be stimulated by the first coil unit (91) and the second nerve can be stimulated by the second coil unit (93).

Abstract: A transducer apparatus for delivering tumor treating fields to a subject's body, including: a substrate; an electrode element coupled to the substrate; a layer of anisotropic material electrically coupled to the electrode element, wherein the electrode element is located between the substrate and the layer of anisotropic material having a front face and a back face, wherein the back face of the layer of anisotropic material faces the electrode element; a non-conductive material border disposed over an outer perimeter of the layer of anisotropic material, the non-conductive material border being electrically non-conductive, wherein, when viewed in a direction perpendicular to the front face of the layer of anisotropic material: an inner edge of the non-conductive material border overlaps a portion of the front face of the layer of anisotropic material, and an outer edge of the non-conductive material border extends outside the outer perimeter of the layer of anisotropic material.

Abstract: An adhesive layer for use in a transducer apparatus, the adhesive layer extending in an x-y plane and having an adhesive layer outer edge, the adhesive layer including: an adhesive matrix material; a plurality of electrically conductive particles embedded at least partially within the adhesive matrix material forming a conductive adhesive region of the adhesive layer; and at least one non-conductive edge portion comprising an adhesive devoid of electrically conductive particles, the at least one non-conductive edge portion being electrically non-conductive; wherein, when viewed in a direction perpendicular to the x-y plane, a first non-conductive edge portion is located adjacent to and extends along an outer edge of the conductive adhesive region and forms at least a portion of an outer perimeter of the adhesive layer.

Abstract: Described herein are methods and systems for the identification and selection of a neurostimulation target for treating neurological or psychiatric disorders in a subject using functional connectivity networks. The methods and systems may analyze the connectivity or synchrony between deeper brain regions of interest that have been divided into parcels with surface regions of the brain. The methods and systems generally reduce the computational complexity of the targeting algorithm, which in turn may result in a more reliable determination of the neurostimulation targets. Additionally, the methods and systems may personalize the target for neurostimulation, which may improve the overall efficacy of the neurostimulation treatment. Methods and systems that use a decision algorithm to calculate a weight value for a plurality of seed-circuit pairs, and determine a neurostimulation target based on the seed-circuit pair having the greatest weight value are also described herein.

Abstract: The present invention relates to angle-tuned (AT) ring coil devices to reduce the individual coil footprint and improve depth-spread characteristics of transcranial magnetic stimulation (TMS) systems. The AT coil device includes multiple stacked coils, which enhances field strength, reduces the footprint, and increases the field penetration depth by modifying its geometric distribution. Moreover, the AT coil devices demonstrated superior performance for multisite stimulation due to their smaller footprint, making them suitable for multisite stimulations of inter and intra-hemispheric brain regions with an improved spread and less electric field divergence.

Abstract: The Method for the treatment of patients with viral infections such as COV-2-BARS or others using Microwave Resonant Absorption (MRA) effect in viruses and based on Structure Resonant Energy Transfer (SRET) that causes Confined Acoustic Vibrations (CAV) in infectious viruses and, as a result, their destruction. Devices using coupling of multi-frequency microwave energy to the patient organs infected with virus with Near Field Focused (NFF) antenna arrays, implemented to irradiate infected organs such as lungs, larynx, and nasofarinx by exciting high amplitude acoustic vibrations to fracture the outer protein shell (capsid) of the virus and completely or, at least, partially inactivate it.

Abstract: A control circuit accesses a radiation treatment plan for a given patient. The control circuit then generates dose volume histogram information as a function of the radiation treatment plan and automatically assesses the dose volume histogram information to identify any anomalous results. Generating that information can comprise, at least in part and for example, generating at least one dose volume histogram curve. The latter may comprise generating at least one dose volume histogram curve for each of a plurality of different patient structures (such as one or more treatment volumes and/or one or more organs-at-risk).

Abstract: A control circuit accesses a plurality of information items that each correspond to a resultant dose volume histogram shape for a corresponding different radiation treatment plan. The control circuit then trains a machine learning model to predict a desired dose volume histogram shape using that plurality of information items as a training corpus.

Abstract: A photodynamic therapy and microwave therapy fusion system is provided. The system includes photosensitizers transplanted or attached to the biological tissues of a site in which cancer develops and made to have specific indirect energy band gaps so as to perform photodynamic therapy for the site in which the cancer develops; and a microwave assisted photodynamic therapy (MWAPDT) controller connected to a personal computer (PC) and adapted to allow a microwave frequency of 500 MHz to 10 GHz emitted from a microwave probe or an optic ray emitted from a fiber optic probe or a LED light of a wavelength of 300 to 1,000 nm from a micro LED of a LED probe to be irradiated onto the biological tissues of the site in which the cancer develops, to which the photosensitizers are transplanted or attached, so as to perform microwave therapy for the site in which the cancer develops.

Abstract: An intracranial photobiomodulation system (IPS) comprises a removeable light therapy implant and a permanent sheath. The removeable light therapy implant is adapted to be removably secured to the sheath and has (i) a support arm having a proximal end and a distal end, and (ii) at least one light source located along the support arm. The at least one light source is configured to emit light of at least one wavelength and at least one intensity. The permanent sheath comprises a shell and a sleeve. The shell is adapted to be permanently secured to a patient's scalp and the sleeve is made of a transparent material that allows light to pass therethrough and has a proximal opening and a distal closed tip, the proximal opening is adapted to removably receive the support arm and light source of the removeable light therapy implant.

Abstract: We disclose a method, comprising administering, to a patient suffering from a cancer, low-dose radiation, whereby expression of a target on a surface of a cancer cell increases after the low-dose radiotherapy; and administering, to the patient, a cell-based target-specific cancer therapy, wherein a cell of the cancer therapy interacts with the target. The method may further comprise administering an additional cancer treatment modality. We also disclose a kit comprising a cell of the cell-based target-specific cancer therapy; and instructions to perform the method. Further, we disclose a similar method and corresponding kit, wherein low-dose radiation induces expression of an intracellular target, and a small molecule cancer therapy interacting with the intracellular target is administered.

Abstract: Provided herein is radiotherapy treatment system (100) for assisting treatment of a subject in an external radiotherapy programme comprising one or more external radiotherapy treatment sessions, the system (100) comprising a robotic arm, RA, (400, 400a) having a base end (422, 422a) and an effector end and a steering guide (300) having a proximal (40) and distal (20) end comprising a rigid effector shaft (310) at the distal end (20) configured for insertion into the canal (602) of the subject (50), or for attachment to an inserter (204) configured for insertion into the canal (602) of the subject (50), wherein the positioning tool (200) is configured to move and/or fix the canal (602) for the external radiotherapy treatment session responsive to movements of the robotic arm.

Abstract: A control circuit presents to a user an automatic radiation treatment plan optimizer that provides pre-existing accuracy input parameters and that includes an opportunity to select a stereotactic body radiation treatment planning mode in addition to other treatment planning modes. In response to a user selecting the stereotactic body radiation treatment planning mode, the control circuit automatically overrides at least one of the pre-existing accuracy input parameters when automatically optimizing a radiation treatment plan.

Abstract: Systems and methods for simulating radiation effect for cardiac ablation can include a processor generating a heart simulation model configured to simulate electrical activities of the heart of the patient. The processor can determine a simulated post-radiation state of the heart of the patient by adjusting the heart simulation model to account for an effect of a radiation treatment plan on simulated electrical activities of the heart of the patient. The processor can simulate, using the adjusted heart simulation model, the simulated post-radiation state of the heart with a stimulation to induce a heart rhythm disorder, determine whether the heart rhythm disorder is induced based on electrical activities generated when simulating the simulated post-radiation state of the heart with the stimulation, and output an indication of whether the heart rhythm disorder is induced. The processor can suggest modifications to the radiation plan if the heart rhythm disorder is induced.

Abstract: A method of determining treatment geometries for a radiotherapy treatment includes providing a patient model having one or more regions of interest (ROIs); defining a delivery coordinate space (DCS); for each beam's eye view (BEV) plane of each vertex in the DCS, and for each ROI, evaluating a dose of the ROI using transport solutions; evaluating a BEV scores of each pixel of the BEV plane using the doses of the one or more ROIs; determining one or more BEV regions in the BEV plane based on the BEV scores; determining a BEV region connectivity manifold based on the BEV regions; determining a set of treatment trajectories based on the BEV region connectivity manifold; and determining one or more IMRT fields. Each treatment trajectory defines a path through a set of vertices in the DCS. Each IMRT field defines a direction of incidence corresponding to a vertex in the DCS.

Abstract: Systems and methods for predicting a location of a target heart region for cardiac ablation can include one or more processors generating a 3D model of a heart of a patient based on medical images of the patient, and estimating, using the 3D model of the heart and electrophysiology data of the patient, one or more mechanical properties that drive motion of the patient's heart. The one or more processors can generate, using the 3D model and the one or more mechanical properties, a simulated motion pattern of the patient's heart over at least a portion of a cardiac cycle, and identify a region of interest (ROI) of the heart of the patient to be radiated. The one or more processors can determine, using the simulated motion pattern of the heart of the patient, a location of the ROI at a predefined time instance within the cardiac cycle.

Abstract: The present invention relates to the field of radiation therapy and methods, software and systems for adaptive radiotherapy. There is provided a method for adaptive radiotherapy treatment of a patient comprising receiving a sequence of measurement data of the treatment, the measurements being captured at different time points, mapping measurement data to a representation of a treatment geometry at the time points, using the representation in a dynamical model describing how variables in the representation evolve over time, based on the dynamical model, estimating positions over time of the treatment geometry or selected parts of the treatment geometry, determining a treatment action for the patient at a defined time point using the estimation from the dynamical model and executing the treatment action at the defined time point.

Abstract: The present disclosure provides methods and systems for dose distribution prediction. The methods comprise obtaining historical state information and current state information of a target subject. The current state information may reflect the state of the target subject in a current treatment fraction, and the historical state information may reflect the state of the target subject prior to the current treatment fraction. The methods also comprise determining a feature parameter of at least one optimization target with respect to the current treatment fraction, and predicting a current dose distribution to be used in the current treatment fraction based on at least part of the historical state information, the current state information, and the feature parameter of the at least one optimization target using a dose prediction model, the dose prediction model being a trained machine learning model.

Abstract: Systems and methods for cardiac radioablation treatment and planning are disclosed. In some examples, a computing device receives a first image of a patient that was captured for treatment planning. The computing device also receives target definition data characterizing a target area of the patient for treatment. Further, the computing device receives a second image of the patient captured on the day of, and prior to, treatment. The computing device determines whether there is a risk to an organ of the patient based on the first image, the target definition data, and the second image. The computing device also provides for display an indication of risk to the patient based on the determination. For example, the indication of risk can include a treatment target region and an organ at risk region superimposed over the second image. In some examples, the indication of risk includes expected dosage levels.