Patents Issued in January 9, 2024
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Patent number: 11866372Abstract: Systems and methods include a computer-implemented method can be used to make drilling tools from new wurtzite boron nitride (w-BN) superhard material. An ultra-high-pressure, high-temperature operation is performed on pure w-BN powder to synthesize w-BN and cubic boron nitride (c-BN) compact having a first size greater than particles of the pure w-BN powder. The ultra-high-pressure, high-temperature operation includes pressurizing the w-BN powder to a pressure of approximately 20 Gigapascal, heating the w-BN powder at a heating rate of 100° C./minute and cooling the w-BN powder at a cooling rate of 50° C./minute. The compact is cut to a second size smaller than the first size using laser cutting tools. The cut compact is bonded metallurgically, mechanically, or both metallurgically and mechanically onto a tool substrate to form the drilling tool.Type: GrantFiled: May 10, 2021Date of Patent: January 9, 2024Assignees: Saudi Arabian Oil Company, Chengdu Dongwei Technology Co., LTDInventors: Guodong Zhan, Timothy E. Moellendick, Bodong Li, Duanwei He
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Patent number: 11866373Abstract: A method for coating fibers, includes desizing sized short fibers having an average length less than or equal to 5 mm, the short fibers being made of ceramic material or carbon, sieving the desized short fibers in order to separate them from any agglomerates of sized short fibers still present, introducing the desized and sieved short fibers into a reactor, and coating the short fibers in the reactor by chemical vapor deposition in a fluidized bed.Type: GrantFiled: August 25, 2021Date of Patent: January 9, 2024Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SAFRAN CERAMICS, UNIVERSITE DE BORDEAUXInventors: Arnaud Delehouze, Eric Bouillon, Amine El Mansouri, Nathalie Dominique Bertrand, Alain Jean-Michel Guette
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Patent number: 11866374Abstract: A flexible 3D printing feedstock material is disclosed. The flexible 3D printing feedstock material includes 45-80 vol % of a powder having at least one of a metal powder and a ceramic powder, 0-5 vol % of a compatibilizer, 10-35 vol % of a soluble flexibilizer, and 5-35 vol % of a non-soluble binder component. Methods of forming the flexible 3D printing feedstock material by melt mixing the components are disclosed. Methods of producing a 3D printed part by operating a fused deposition modeling 3D printer loaded with a filament formed of the 3D printing feedstock material are also disclosed.Type: GrantFiled: June 26, 2019Date of Patent: January 9, 2024Assignee: MARKFORGED, INC.Inventors: Joseph Roy-Mayhew, Zachary Farrell
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Patent number: 11866375Abstract: Methods of firing ceramic-forming honeycomb bodies are disclosed that include heating the honeycomb bodies and blocking furnace gases from flowing through the honeycomb body by placing a layer selected from the group consisting of a graphite layer, a graphite-containing layer, an activated carbon layer, or an amorphous carbon layer adjacent an endface of the honeycomb body. Heating removes organic pore-forming material and graphite pore-forming material in the honeycomb body. The layer oxidizes to form a porous layer after firing to a first temperature, and furnace gases flow through the honeycomb body.Type: GrantFiled: May 30, 2019Date of Patent: January 9, 2024Assignee: Corning IncorporatedInventors: Thomas Richard Chapman, Patrick David Tepesch, Douglas Richard Wing
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Patent number: 11866376Abstract: A method and apparatus for producing boron nitride nanotubes and continuous boron nitride nanotube yarn or tapes is provided. The apparatus includes rotating reaction tubes that allow for continuous chemical vapor deposition of boron nitride nanotubes. The rotation of the reaction tubes allows the boron nitride nanotubes to be spun into yarns or made into tapes, without post process or external rotation or spinning of the gathered nanotubes. Boron nitride nanotube yarns or tapes of great length can be produced as a result, thereby providing industry with a readily useable format for this type of material. Dopants such as carbon can be added to engineer the band gap of the nanotubes. Catalysts may be formed outside or inside the reactor.Type: GrantFiled: October 29, 2019Date of Patent: January 9, 2024Assignee: University of New HampshireInventors: David S. Lashmore, Tyler Bennett
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Patent number: 11866377Abstract: An article for a high temperature environment includes a first ceramic composite substrate, a second ceramic composite substrate, and a high temperature interface between a first surface of the first ceramic composite substrate and a second surface of the second ceramic composite substrate. The high temperature interface includes at least one high temperature interface layer that includes a ceramic matrix and a plurality of fibers distributed through the ceramic matrix.Type: GrantFiled: April 21, 2021Date of Patent: January 9, 2024Assignee: Honeywell International Inc.Inventors: Mehrad Mehr, Bahram Jadidian
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Patent number: 11866378Abstract: Disclosed is a method for manufacturing a honeycomb structure. The method includes molding a molded body from a mixture containing silicon carbide particles, an organic component, and a dispersion medium, removing the organic component included in the molded body to obtain a porous honeycomb body, and impregnating an inner portion of partition walls of the porous honeycomb body with metal silicon. In a state in which the porous honeycomb body is placed on a support inside a container containing solid metal silicon, the impregnating an inner portion of the partition walls is performed by heating the inside of the container to a temperature higher than or equal to a melting point of the metal silicon so that the porous honeycomb body is impregnated with molten metal silicon through the support that is porous.Type: GrantFiled: March 12, 2019Date of Patent: January 9, 2024Assignee: IBIDEN CO., LTD.Inventors: Sonosuke Ishiguro, Yoshihiro Koga
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Patent number: 11866379Abstract: A method for coating a substrate includes spraying a combination of powders. The combination of powders includes: Hf0.5Si0.5O2; Zr0.5Si0.5O2; and, optionally, at least one of HfO2 and ZrO2. A molar ratio of said Hf0.5Si0.5O2 and HfO2 combined to said Zr0.5Si0.5O2 and ZrO2 combined is from 2:1 to 4:1. A molar ratio of said Hf0.5Si0.5O2 to said HfO2 is at least 1:3.Type: GrantFiled: August 13, 2021Date of Patent: January 9, 2024Assignee: RTX CorporationInventors: Xuan Liu, James T. Beals, Xia Tang, Richard Wesley Jackson, William J. Joost
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Patent number: 11866380Abstract: A method of fabricating a coating includes providing a ceramic matrix composite that includes SiC fibers disposed in a SiC matrix, depositing a base slurry on the ceramic matrix composite, wherein the base slurry contains powders of a metal oxide, at least one of silicon carbide, silicon nitride, or free silicon, and barium-magnesium-aluminosilicate in a first carrier fluid, drying the deposited base slurry to produce a base green layer, depositing a transition slurry on the base green layer, wherein the transition slurry contains powders of a metal oxide, at least one of silicon carbide, silicon nitride, or free silicon, at least one of zirconium carbide, zirconium nitride, or zirconium oxide, and barium-magnesium-aluminosilicate in a second carrier fluid, drying the deposited transition slurry to produce a transition green layer, and forming a consolidated coating on the ceramic matrix composite by heating the base green layer and the at least one transition green layer to cause chemical reactions that convType: GrantFiled: August 9, 2019Date of Patent: January 9, 2024Assignee: RTX CORPORATIONInventors: Imelda P. Smyth, Sarah A. Frith
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Patent number: 11866381Abstract: An assemblage appliance and method of recycling organic waste into biogas and liquid fertilizer, implementing essentially anaerobic digestion processes, is described. The assemblage appliance includes: a pliant structured exoskeletal envelope, pliable collapsible anaerobic digester and gas tank. A compact kit-of-parts for assembling the aforementioned appliance and respective method using the aforementioned appliance for recycling organic waste into biogas and liquid fertilizer are described.Type: GrantFiled: June 25, 2018Date of Patent: January 9, 2024Inventors: Oshik Moshe Efrati, Yair Teller, Erez Lanzer, Shoham Zak
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Patent number: 11866382Abstract: The present invention relates to improving the efficacy of man-made and/or natural organic-based animal manure fertilizers by administration of an organic solvent formula containing polyorganic acids and/or their salts. The formulation liberates nutrient(s) that are normally bound in the soil as insoluble salts and complexes. These delivery formulations also provide an environmentally sound and inherently safe solvating system that improves diffusion of polyorganic acids to the granule fertilizer. These delivery formulations enable safe storage, transport and subsequent application or blending with solid or liquid fertilizers. The combined formulation and fertilizer can be applied to soil to provide improved efficacy of fertilizer by liberating nutrients bound in the soil for uptake by plant life.Type: GrantFiled: July 20, 2021Date of Patent: January 9, 2024Assignee: SOILGENIC TECHNOLOGIES, LLCInventors: Gary David McKnight, Randall Linwood Rayborn
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Patent number: 11866383Abstract: A nitrification inhibiting composition for use in agricultural applications includes from about 5% to about 15% propylene glycol methyl ether and from about 20% to about 35% dicyandiamide. The nitrification inhibiting composition may be combined with a fertilizer and applied to plants or soil to increases the effectiveness of the fertilizer, thereby positively impacting crop yield and quality.Type: GrantFiled: April 4, 2019Date of Patent: January 9, 2024Assignee: SYNSUS PRIVATE LABEL PARTNERS, LLCInventors: Douglas Hocking, Robert Munion
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Patent number: 11866384Abstract: Compositions include dicyandiamide (DCD), N-(N-butyl) Thiophosphoric Triamide (NBPT), and styrene-maleic anhydride copolymer in a solution. Agricultural fertilizer compositions contain the DCD, NBPT and styrene-maleic anhydride copolymer composition in combination with a fertilizer.Type: GrantFiled: August 12, 2021Date of Patent: January 9, 2024Assignee: SYNSUS PRIVATE LABEL PARTNERS, LLCInventors: Douglas Hocking, Robert Munion
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Patent number: 11866385Abstract: A coating composition comprising an adduct formed by chemical reaction of a monomer containing poly-thiol with a monomer containing one or more unsaturated carbon-carbon bond; more particularly relates to coated agrochemical compositions coated with said coating composition.Type: GrantFiled: October 30, 2018Date of Patent: January 9, 2024Assignee: EVERRIS INTERNATIONAL B.V.Inventors: Evgeniy Tkalya, Ronald Petrus Johannes Gosens, Susan Tine Kathelyne Sijstermans, Michael Ernest Josephina Hendriks, Martin Anna Fransiscus Jacobus. Marx, Karina Rabe, Gerardus Jacobus Joseph Out
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Patent number: 11866386Abstract: A method of reducing an aromatic ring or a cyclic, allylic ether in a compound includes preparing a reaction mixture including a compound including an aromatic moiety or a cyclic, allylic ether moiety, an alkali metal, and either ethylenediamine, diethylenetriamine, triethylenetetramine, or a combination thereof, in an ether solvent; and reacting the reaction mixture at from ?20° C. to 30° C. for a time sufficient to reduce a double bond in the aromatic moiety to a single bond or to reduce the cyclic, allylic ether moiety.Type: GrantFiled: September 17, 2021Date of Patent: January 9, 2024Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Kazunori Koide, James Proviano Burrows
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Patent number: 11866387Abstract: A process for producing methacrylic acid or a methacrylic acid ester including, producing acrolein, reacting the produced acrolein with hydrogen to produce propanal, reacting the propanal with formaldehyde to produce methacrolein, and oxidizing the methacrolein in the presence of an oxygen containing gas and optionally an alcohol, to methacrylic acid or a methacrylic acid ester.Type: GrantFiled: July 11, 2019Date of Patent: January 9, 2024Assignee: Röhm GmbHInventors: Alexander May, Steffen Krill, Marcel Treskow, Diego Carambia, Gabriel Avella
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Patent number: 11866388Abstract: Catalyst systems suitable for tetramerizing ethylene to form 1-octene may include a catalyst having a structure according to Formula (VI) or Formula (VII). In Formulas (VI) and (VII), X is a halogen, a (C2-C30) carboxylate, acetylacetonate, or a (C1-C30) hydrocarbyl; L1 is a neutral coordinating ligand; n is an integer from 0 to 6; Y is a (C6-C20)fluorine-substituted aryl, a (C6-C20)fluorine-substituted aryloxy, or a (C1-C20)fluorine-substituted alkoxy; and L?L is a bidentate chelating ligand. The catalyst system may also include an aluminum containing agent which includes a reaction product of an organoaluminum compound and an antifouling compound. The antifouling compound may include one or more organic acids, organic acid salts, esters, anhydrides, or combinations of these.Type: GrantFiled: February 8, 2023Date of Patent: January 9, 2024Assignee: SAUDI ARABIAN OIL COMPANYInventors: Sohel Shaikh, Motaz Khawaji, Wei Xu
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Patent number: 11866389Abstract: According to embodiments, a process of forming a catalyst for aromatizing hydrocarbons may include enhancing a mesoporosity of a zeolite support by a base-leaching treatment, an acid-leaching treatment, or both to form a zeolite support having enhanced mesoporosity, mixing the zeolite support having enhanced mesoporosity with a solution containing zinc or gallium to disperse the zinc or gallium on the zeolite support having enhanced mesoporosity, and calcining the zeolite support having enhanced mesoporosity with zinc or gallium dispersed thereon to form a zinc- or gallium-doped zeolite catalyst having a mesopore volume of greater than 0.09 cm3/g and less than 0.20 cm3/g.Type: GrantFiled: September 7, 2022Date of Patent: January 9, 2024Assignees: Saudi Arabian Oil Company, King Fahd University of Petroleum and MineralsInventors: Yaming Jin, Ziyauddin S. Qureshi, Abdullah M. Aitani, Omer Refa Koseoglu, Mohammad Naseem Akhtar, Hassan Saeed Al-Awad Alasiri
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Patent number: 11866390Abstract: The present disclosure provides compounds useful as anesthetics, such as topical anesthetics, of general formula (VIIIi): wherein: R2?H or Me; R3?H or Me; R4=Alkyl; R5?O-Alkyl; and Alkyl=aliphatic C1-C4 alkyl. The present disclosure further provides methods of making compounds of general formula (VIIIi), compositions comprising a therapeutically effective amount of a compound of general formula (VIIIi), and methods of treating or preventing pain in a subject by administering (e.g., topically applying) compositions comprising an effective amount of a compound of general formula (VIIIi) to the subject.Type: GrantFiled: July 25, 2023Date of Patent: January 9, 2024Assignee: PTC Innovations, LLCInventors: Pendleton Wickersham, Stephen Bendel, Todd Mathis, Christian Warren
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Patent number: 11866391Abstract: The present disclosure provides compounds useful as anesthetics, such as topical anesthetics, of general formula (VIIIk): wherein: R2?H or Me; R3?H or Me; R4=Alkyl; R5?O-Alkyl; and Alkyl=aliphatic C1-C4 alkyl. The present disclosure further provides methods of making compounds of general formula (VIIIk), compositions comprising a therapeutically effective amount of a compound of general formula (VIIIk), and methods of treating or preventing pain in a subject by administering (e.g., topically applying) compositions comprising an effective amount of a compound of general formula (VIIIk) to the subject.Type: GrantFiled: July 25, 2023Date of Patent: January 9, 2024Assignee: PTC Innovations, LLCInventors: Pendleton Wickersham, Stephen Bendel, Todd Mathis, Christian Warren
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Patent number: 11866392Abstract: The present disclosure provides compounds useful as anesthetics, such as topical anesthetics, of general formula (XIII): wherein: R8=NH2, NH(Me), N(Me)2, The present disclosure further provides methods of making compounds of general formula (XIII), compositions comprising a therapeutically effective amount of a compound of general formula (XIII), and methods of treating or preventing pain in a subject by administering (e.g., topically applying) compositions comprising an effective amount of a compound of general formula (XIII) to the subject.Type: GrantFiled: July 26, 2023Date of Patent: January 9, 2024Assignee: PTC Innovations, LLCInventors: Pendleton Wickersham, Stephen Bendel, Todd Mathis, Christian Warren
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Patent number: 11866393Abstract: Disclosed are 7,7?-dihalo-3,3,3?,3?-tetramethyl-1,1?-spirobiindane and a preparation method thereof. The 7,7?-dihalo-3,3,3?,3?-tetramethyl-1,1?-spirobiindane is a compound represented by formula I, or an enantiomer, a raceme or a diastereomer thereof. The compound of formula I could be prepared by using a racemic or optically active 3,3,3?,3?-tetramethyl-1,1?-spirobiindane-6,6?-diol as a raw material through a series of reactions. The 7,7?-dihalo-3,3,3?,3?-tetramethyl-1,1?-spirobiindane is a key intermediate for preparing 3,3,3?,3?-tetramethyl-1,1?-spirobiindane-based phosphine ligand compounds represented by formula II or III.Type: GrantFiled: March 22, 2022Date of Patent: January 9, 2024Assignee: Zhejiang UniversityInventors: Xufeng Lin, Linxi Yao, Shirui Chang, Lei Wang
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Patent number: 11866394Abstract: Prodrugs of hydroxamate-based GCPII inhibitors and methods of their use for treating a disease or condition are disclosed.Type: GrantFiled: July 12, 2021Date of Patent: January 9, 2024Assignees: THE JOHNS HOPKINS UNIVERSTY, INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY AS CR V.V.I.Inventors: Barbara Slusher, Rana Rais, Jan Vavra, Tomas Tichy, Pavel Majer, Andrej Jancarik, Lukas Tenora
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Patent number: 11866395Abstract: A method of producing petrochemicals using a hydrocarbon fuel cell includes the steps of operating the fuel cell to produce electricity, thermal energy, and one or more exhaust stream, the one or more exhaust stream comprising at least a carbon-containing gas and water, reacting at least a portion of the exhaust stream with the reactant stream of natural gas to produce one or more petrochemical streams in a reactor, and heating one or more reactants using at least a portion of at least one of the electricity and the thermal energy.Type: GrantFiled: February 7, 2019Date of Patent: January 9, 2024Assignees: 1304338 Alberta Ltd., 1304342 Alberta Ltd.Inventors: Jose Lourenco, MacKenzie Millar
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Patent number: 11866396Abstract: The present invention relates to an NCC process and an apparatus for producing light olefins and aromatics, wherein the C5+ fraction (16) of the cracking effluent is separated into a C5 fraction (25) recycled into the NCC reactor (4) and a C6+ fraction (26), and wherein the C6+ fraction (26) is sent into an aromatics extraction unit (30) to produce an aromatics-enriched fraction (31) and a low-aromatics fraction (32).Type: GrantFiled: December 15, 2020Date of Patent: January 9, 2024Assignee: IFP ENERGIES NOUVELLESInventors: Olivier Thinon, Anne Claire, Vania Santos-Moreau
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Patent number: 11866397Abstract: A process for upgrading a hydrocarbon feed to produce light olefins, includes contacting the hydrocarbon feed with steam in the presence of a cracking catalyst in a steam catalytic cracking reactor at reaction conditions sufficient to cause at least a portion of the hydrocarbons in the hydrocarbon feed to undergo one or more cracking reactions to produce a steam catalytic cracking effluent comprising ethylene, propylene, or both, wherein the process is capable of being transitioned between an ethylene-selective mode and a propylene-selective mode; determining whether to produce ethylene or propylene; when producing ethylene, then operating the process in ethylene-selective mode comprises producing more ethylene than propylene; or when producing propylene, then operating the process in propylene-selective mode comprises producing more propylene than ethylene.Type: GrantFiled: March 14, 2023Date of Patent: January 9, 2024Assignee: SAUDI ARABIAN OIL COMPANYInventors: Mohammed Z. Albahar, Emad N. Al-Shafei, Mohammed F. Aljishi, Ali N. Aljishi, Ali S. Alnasir
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Patent number: 11866398Abstract: This invention relates generally to the synthesis of ?12-Prostaglandin J product using stereoretentive ruthenium olefin metathesis catalysts supported by dithiolate ligands. ?12-Prostaglandin J products were generated with excellent selectivity (>99% Z) and in moderate to high/good yields (47% to 80% yield; 58% to 80% yield).Type: GrantFiled: May 14, 2019Date of Patent: January 9, 2024Assignee: California Institute of TechnologyInventors: Jiaming Li, Xu Chen, Tonia S. Ahmed, Brian M. Stoltz, Robert H. Grubbs
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Patent number: 11866399Abstract: Process for hydroformylation of olefins using Pt and bromine.Type: GrantFiled: December 13, 2022Date of Patent: January 9, 2024Assignee: EVONIK OPERATIONS GMBHInventors: Carolin Schneider, Ralf Jackstell, Matthias Beller, Robert Franke
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Patent number: 11866400Abstract: Process for hydroformylation of olefins using Pt and DPEphos.Type: GrantFiled: December 13, 2022Date of Patent: January 9, 2024Assignee: EVONIK OPERATIONS GMBHInventors: Carolin Schneider, Ralf Jackstell, Matthias Beller, Robert Franke
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Patent number: 11866401Abstract: A salicyl fumarate derivative having the general structural formula (A): In the structural formula (A), R1 is one of H+, Na+, K+or NH4+. R2 is one of fumaric acid ester products. The derivative has the general structural formula of the combination of salicylic acid and fumaric acid through an esterification reaction. This category of compounds possesses good effects in treatment of neurodegenerative diseases.Type: GrantFiled: November 27, 2020Date of Patent: January 9, 2024Assignee: CHONGQING NEUROPARK BIOSCIENCE CO., LTD.Inventors: Lichuan Yang, Bobby Thomas, Mingyue Guo
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Patent number: 11866402Abstract: The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.Type: GrantFiled: April 30, 2021Date of Patent: January 9, 2024Assignee: Corsair Pharma, Inc.Inventors: Xiaoming Zhang, Meenakshi S. Venkatraman, Cyrus K. Becker
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Patent number: 11866403Abstract: The present invention provides a carboxylic acid ester compound represented by formula (1) that is useful as a fragrance component or as a formulated fragrance material, wherein R1 is —COOR, wherein R is an alkyl group having 1 to 4 carbon atoms.Type: GrantFiled: May 28, 2019Date of Patent: January 9, 2024Assignee: Mitsubishi Gas Chemical Company, Inc.Inventors: Yutaka Matsuura, Tomohiko Hakamata
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Patent number: 11866404Abstract: The present disclosure relates to the formation of terephthalate esters.Type: GrantFiled: June 17, 2021Date of Patent: January 9, 2024Assignee: 9449710 CANADA INC.Inventors: Adel Essaddam, Fares Essaddam
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Patent number: 11866405Abstract: The present application relates to chemical compounds of Formula (A): and pharmaceutically acceptable salts thereof, wherein X, R1, and R2 are as defined herein. The chemical compounds of Formula (A) inhibit IRAK4 and consequently have potential utility in medicine.Type: GrantFiled: December 1, 2021Date of Patent: January 9, 2024Assignee: AstraZeneca ABInventors: Ina Terstiege, Stefan Schiesser, Yafeng Xue, Hui-Fang Chang, Anna Ingrid Kristina Berggren
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Patent number: 11866406Abstract: This disclosure describes compounds of Formula (I), stereoisomers, side compounds thereof, pharmaceutical compositions and methods of manufacturing such compounds, using silylation reagents and producing compositions and products made using such methods. More particularly, this disclosure describes manufacture of trofinetide and side products, compositions and products containing such compounds, for pharmaceutical uses to treat neurodegenerative or neurodevelopmental disorders.Type: GrantFiled: June 23, 2022Date of Patent: January 9, 2024Assignee: NEUREN PHARMACEUTICALS LIMITEDInventors: Clive Blower, Mathew Peterson, James Murray Shaw, James Anthony Bonnar, Etienne David Frank Philippe Moniotte, Martin Bernard Catherine Bousmanne, Cecilia Betti, Karel Willy Luc Decroos, Mimoun Ayoub
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Patent number: 11866407Abstract: This invention is in the field of medicinal chemistry and relates to a new class of small-molecules having a pyrrolidinone-acetamide (or similar) structure (e.g., Formula I) which function as inhibitors of the SARS-CoV-2 papain-like protease (PLpro), which function as inhibitors of the SARS-CoV-2 related viral 3CL protease (MPpro), which function as therapeutics for the treatment of viral infection characterized with PLPpro and/or Mpro protease activity and/or expression (e.g., COVID-19), and which function as therapeutics for the treatment of other conditions characterized with PLPpro and/or Mpro protease activity and/or expression.Type: GrantFiled: April 19, 2022Date of Patent: January 9, 2024Assignee: Arizona Board of Regents on Behalf of the University of ArizonaInventor: Jun Wang
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Patent number: 11866408Abstract: Described herein are compounds that are derivatives of DMT or 5-MeO-DMT and can be metabolically converted to N,N-dimethyltryptamine or analogs thereof upon administration to a subject. In certain embodiments, the compounds described herein are useful for the treatment of conditions associated with a neurological disease.Type: GrantFiled: February 23, 2023Date of Patent: January 9, 2024Assignee: TERRAN BIOSCIENCES INC.Inventors: Matthew Alexander James Duncton, Sam Clark
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Patent number: 11866409Abstract: Provided are ARTS mimetic compounds that act as novel antagonists for XIAP and Bcl-2. Further, the novel ARTS mimetic compounds of the presently claimed subject matter induce apoptosis and/or differentiation in premalignant and malignant cells and thereby restore their normal-like phenotype. Further provided are compositions, methods and uses of said ARTS mimetic compounds in the treatment of cancer and premalignant conditions.Type: GrantFiled: November 2, 2016Date of Patent: January 9, 2024Assignee: CARMEL-HAIFA UNIVERSITY ECONOMIC CORPORATION LTD.Inventors: Sarit Larisch, Dalit Barkan
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Patent number: 11866410Abstract: The present invention relates to a new process for manufacturing (6aR,10aR)-7-propyl-6,6 a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4?,5?:5,6]benzo[1,2-g]quinoline with formula (Ib) below, (4aR,10aR)-1-Propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinoline-6,7-diol with formula (I) below and salts thereof. Both compounds are for use in the treatment of neurodegenerative diseases and disorders such as Parkinson's Disease. The invention also relates to new intermediate compounds of said process.Type: GrantFiled: October 7, 2021Date of Patent: January 9, 2024Assignee: H. Lundbeck A/SInventors: Mikkel Fog Jacobsen, Martin Juhl, Kåre Søndergaard
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Patent number: 11866411Abstract: Compounds and compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.Type: GrantFiled: March 8, 2021Date of Patent: January 9, 2024Assignee: Agios Pharmaceutical, Inc.Inventors: Francesco G. Salituro, Jeffrey O. Saunders, Shunqi Yan
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Patent number: 11866412Abstract: Novel acridin-9-one derivative compounds having broad spectrum antibacterial activity, a method of making said compounds, methods of using said compounds, and a pharmaceutical composition comprising said compound(s) are provided. The acridin-9-one compounds have antimicrobial activity against various susceptible and resistant gram-positive and gram-negative bacteria as well as drug resistant bacteria. They act as DNA gyrase and topoisomerase IV inhibitors and are satisfiable as a drug for infectious treatment.Type: GrantFiled: March 3, 2023Date of Patent: January 9, 2024Assignee: KING FAISAL UNIVERSITYInventors: Christophe Tratrat, Michelyne Haroun
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Patent number: 11866413Abstract: Disclosed is a method for refining 5-fluorouracil, comprising the following steps: dissolving 5-fluorouracil in an organic solvent, preferably DMSO, heating and stirring until dissolved; naturally cooling the filtrate until a crystal is precipitated; filtering, washing a filter cake using a polar solvent, and draining and drying under reduced pressure. By using the new refining method, the content of impurities in 5-fluorouracil may be reduced to less than 0.01%, the product purity is more than 99.98%, and the refining yield is higher than 70%. In addition, the refining method of the present invention has a simple process, convenient operation, low production costs, high product purity, a stable process, and is suitable for industrial production.Type: GrantFiled: January 10, 2020Date of Patent: January 9, 2024Assignee: SHANGHAI XUDONG HAIPU PHARMACEUTICAL CO., LTDInventors: Xiaolin Chen, Pengfei Gao, Yike Yang, Yi Liang, Yafeng Zhan
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Patent number: 11866414Abstract: There are disclosed compounds of the following formula I: or a stereoisomer or pharmaceutically acceptable salt thereof, wherein all substituents are as defined herein, which are useful in the modulation of IL-12, IL-23 and/or IFN?, by acting on Tyk-2 to cause signal transduction inhibition. The compounds of the invention may be useful for treating neurodegenerative diseases or disorders.Type: GrantFiled: May 13, 2022Date of Patent: January 9, 2024Assignee: BRISTOL-MYERS SQUIBB COMPANYInventors: Steven H. Spergel, Ryan M. Moslin, Michael Edward Mertzman, Zili Xiao
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Patent number: 11866415Abstract: Provided herein is a method of forming a beta-lactone from a carboxylic acid having a beta-carbon with a hydrogen atom disposed thereon. The method comprises contacting a carboxylic acid of formula (1) as described herein with an effective amount of a palladium(II) catalyst, an effective amount of an N-protected aminoacid ligand, and t-butylhydroperoxide in a solvent comprising hexafluoroisopropanol (HFIP), at about 60° C. to provide a beta-lactone of formula (2) as described herein.Type: GrantFiled: May 29, 2020Date of Patent: January 9, 2024Assignee: The Scripps Research InstituteInventors: Jin-quan Yu, Zhe Zhuang
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Patent number: 11866416Abstract: The present invention is related to the inhibition of the formation of Streptococci biofilms through the inhibition of glucosyl transferase (Gtf). Compounds, compositions and methods for inhibiting Streptococcus biofilm formation, as well as for preventing, inhibiting and/or treating the formation of dental caries, and methods of identifying compounds that prevent, inhibit and/or treat the formation of dental caries are provided.Type: GrantFiled: April 3, 2019Date of Patent: January 9, 2024Assignee: UAB Research FoundationInventors: Sadanandan E. Velu, Hui Wu, Qiong Zhang, Bhavitavya Nijampatnam
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Patent number: 11866417Abstract: Provided herein is a crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione hemihydrate. Pharmaceutical compositions comprising the crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione hemihydrate are also disclosed.Type: GrantFiled: October 1, 2020Date of Patent: January 9, 2024Assignee: Celgene CorporationInventor: Jerry Lee Atwood
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Substituted benzofuran, benzopyrrole, benzothiophene, and structurally related complement inhibitors
Patent number: 11866418Abstract: Disclosed are compounds of formulae I and II, and pharmaceutically acceptable salts and prodrugs thereof, which are inhibitors of the complement system. Also provided are pharmaceutical compositions comprising such a compound, and methods of using the compounds and compositions in the treatment or prevention of a disease or condition characterized by aberrant complement system activity.Type: GrantFiled: April 27, 2022Date of Patent: January 9, 2024Assignee: BioCryst Pharmaceuticals, Inc.Inventors: Pravin L. Kotian, Yarlagadda S. Babu, Weihe Zhang, Peng-Cheng Lu, Minwan Wu, Wei Lv, Trung Xuan Nguyen, Zhao Dang, Venkat R. Chintareddy, V. Satish Kumar, Krishnan Raman -
Patent number: 11866419Abstract: The present invention relates to the following compounds wherein the integers are as defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of tuberculosis.Type: GrantFiled: September 17, 2021Date of Patent: January 9, 2024Assignee: Janssen Sciences Ireland Unlimited CompanyInventors: Jérôme Émile Georges Guillemont, Magali Madeleine Simone Motte, Pierre Jean-Marie Bernard Raboisson, Abdellah Tahri
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Patent number: 11866420Abstract: The present invention relates to novel hydrochloride salt forms of N-(2?,4?-difluoro-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-[1,1?-biphenyl]-3-yl)cyclopropanesulfonamide (I). Compound (I) is a selective inhibitor of FGFR/VEGFR kinase families and is useful in the treatment of cancer.Type: GrantFiled: September 5, 2019Date of Patent: January 9, 2024Assignee: Aurigene Oncology LimitedInventors: David Jonaitis, Oskari Karjalainen
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Patent number: 11866421Abstract: Pyrimidine and Pyridine containing compounds are described herein that are enzyme p70S6K inhibitors useful in the treatment of S6K-dependent or S6K-mediated diseases and conditions, including but not limited to cancer, fibrotic metabolic and certain neurological disorders.Type: GrantFiled: May 31, 2021Date of Patent: January 9, 2024Assignee: Epigen Biosciences, INC.Inventors: Graham Beaton, Fabio Tucci, Satheesh Ravula, Suk Joong Lee, Chandravadan Shah