Patents Issued in January 9, 2024
  • Patent number: 11866372
    Abstract: Systems and methods include a computer-implemented method can be used to make drilling tools from new wurtzite boron nitride (w-BN) superhard material. An ultra-high-pressure, high-temperature operation is performed on pure w-BN powder to synthesize w-BN and cubic boron nitride (c-BN) compact having a first size greater than particles of the pure w-BN powder. The ultra-high-pressure, high-temperature operation includes pressurizing the w-BN powder to a pressure of approximately 20 Gigapascal, heating the w-BN powder at a heating rate of 100° C./minute and cooling the w-BN powder at a cooling rate of 50° C./minute. The compact is cut to a second size smaller than the first size using laser cutting tools. The cut compact is bonded metallurgically, mechanically, or both metallurgically and mechanically onto a tool substrate to form the drilling tool.
    Type: Grant
    Filed: May 10, 2021
    Date of Patent: January 9, 2024
    Assignees: Saudi Arabian Oil Company, Chengdu Dongwei Technology Co., LTD
    Inventors: Guodong Zhan, Timothy E. Moellendick, Bodong Li, Duanwei He
  • Patent number: 11866373
    Abstract: A method for coating fibers, includes desizing sized short fibers having an average length less than or equal to 5 mm, the short fibers being made of ceramic material or carbon, sieving the desized short fibers in order to separate them from any agglomerates of sized short fibers still present, introducing the desized and sieved short fibers into a reactor, and coating the short fibers in the reactor by chemical vapor deposition in a fluidized bed.
    Type: Grant
    Filed: August 25, 2021
    Date of Patent: January 9, 2024
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SAFRAN CERAMICS, UNIVERSITE DE BORDEAUX
    Inventors: Arnaud Delehouze, Eric Bouillon, Amine El Mansouri, Nathalie Dominique Bertrand, Alain Jean-Michel Guette
  • Patent number: 11866374
    Abstract: A flexible 3D printing feedstock material is disclosed. The flexible 3D printing feedstock material includes 45-80 vol % of a powder having at least one of a metal powder and a ceramic powder, 0-5 vol % of a compatibilizer, 10-35 vol % of a soluble flexibilizer, and 5-35 vol % of a non-soluble binder component. Methods of forming the flexible 3D printing feedstock material by melt mixing the components are disclosed. Methods of producing a 3D printed part by operating a fused deposition modeling 3D printer loaded with a filament formed of the 3D printing feedstock material are also disclosed.
    Type: Grant
    Filed: June 26, 2019
    Date of Patent: January 9, 2024
    Assignee: MARKFORGED, INC.
    Inventors: Joseph Roy-Mayhew, Zachary Farrell
  • Patent number: 11866375
    Abstract: Methods of firing ceramic-forming honeycomb bodies are disclosed that include heating the honeycomb bodies and blocking furnace gases from flowing through the honeycomb body by placing a layer selected from the group consisting of a graphite layer, a graphite-containing layer, an activated carbon layer, or an amorphous carbon layer adjacent an endface of the honeycomb body. Heating removes organic pore-forming material and graphite pore-forming material in the honeycomb body. The layer oxidizes to form a porous layer after firing to a first temperature, and furnace gases flow through the honeycomb body.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: January 9, 2024
    Assignee: Corning Incorporated
    Inventors: Thomas Richard Chapman, Patrick David Tepesch, Douglas Richard Wing
  • Patent number: 11866376
    Abstract: A method and apparatus for producing boron nitride nanotubes and continuous boron nitride nanotube yarn or tapes is provided. The apparatus includes rotating reaction tubes that allow for continuous chemical vapor deposition of boron nitride nanotubes. The rotation of the reaction tubes allows the boron nitride nanotubes to be spun into yarns or made into tapes, without post process or external rotation or spinning of the gathered nanotubes. Boron nitride nanotube yarns or tapes of great length can be produced as a result, thereby providing industry with a readily useable format for this type of material. Dopants such as carbon can be added to engineer the band gap of the nanotubes. Catalysts may be formed outside or inside the reactor.
    Type: Grant
    Filed: October 29, 2019
    Date of Patent: January 9, 2024
    Assignee: University of New Hampshire
    Inventors: David S. Lashmore, Tyler Bennett
  • Patent number: 11866377
    Abstract: An article for a high temperature environment includes a first ceramic composite substrate, a second ceramic composite substrate, and a high temperature interface between a first surface of the first ceramic composite substrate and a second surface of the second ceramic composite substrate. The high temperature interface includes at least one high temperature interface layer that includes a ceramic matrix and a plurality of fibers distributed through the ceramic matrix.
    Type: Grant
    Filed: April 21, 2021
    Date of Patent: January 9, 2024
    Assignee: Honeywell International Inc.
    Inventors: Mehrad Mehr, Bahram Jadidian
  • Patent number: 11866378
    Abstract: Disclosed is a method for manufacturing a honeycomb structure. The method includes molding a molded body from a mixture containing silicon carbide particles, an organic component, and a dispersion medium, removing the organic component included in the molded body to obtain a porous honeycomb body, and impregnating an inner portion of partition walls of the porous honeycomb body with metal silicon. In a state in which the porous honeycomb body is placed on a support inside a container containing solid metal silicon, the impregnating an inner portion of the partition walls is performed by heating the inside of the container to a temperature higher than or equal to a melting point of the metal silicon so that the porous honeycomb body is impregnated with molten metal silicon through the support that is porous.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: January 9, 2024
    Assignee: IBIDEN CO., LTD.
    Inventors: Sonosuke Ishiguro, Yoshihiro Koga
  • Patent number: 11866379
    Abstract: A method for coating a substrate includes spraying a combination of powders. The combination of powders includes: Hf0.5Si0.5O2; Zr0.5Si0.5O2; and, optionally, at least one of HfO2 and ZrO2. A molar ratio of said Hf0.5Si0.5O2 and HfO2 combined to said Zr0.5Si0.5O2 and ZrO2 combined is from 2:1 to 4:1. A molar ratio of said Hf0.5Si0.5O2 to said HfO2 is at least 1:3.
    Type: Grant
    Filed: August 13, 2021
    Date of Patent: January 9, 2024
    Assignee: RTX Corporation
    Inventors: Xuan Liu, James T. Beals, Xia Tang, Richard Wesley Jackson, William J. Joost
  • Patent number: 11866380
    Abstract: A method of fabricating a coating includes providing a ceramic matrix composite that includes SiC fibers disposed in a SiC matrix, depositing a base slurry on the ceramic matrix composite, wherein the base slurry contains powders of a metal oxide, at least one of silicon carbide, silicon nitride, or free silicon, and barium-magnesium-aluminosilicate in a first carrier fluid, drying the deposited base slurry to produce a base green layer, depositing a transition slurry on the base green layer, wherein the transition slurry contains powders of a metal oxide, at least one of silicon carbide, silicon nitride, or free silicon, at least one of zirconium carbide, zirconium nitride, or zirconium oxide, and barium-magnesium-aluminosilicate in a second carrier fluid, drying the deposited transition slurry to produce a transition green layer, and forming a consolidated coating on the ceramic matrix composite by heating the base green layer and the at least one transition green layer to cause chemical reactions that conv
    Type: Grant
    Filed: August 9, 2019
    Date of Patent: January 9, 2024
    Assignee: RTX CORPORATION
    Inventors: Imelda P. Smyth, Sarah A. Frith
  • Patent number: 11866381
    Abstract: An assemblage appliance and method of recycling organic waste into biogas and liquid fertilizer, implementing essentially anaerobic digestion processes, is described. The assemblage appliance includes: a pliant structured exoskeletal envelope, pliable collapsible anaerobic digester and gas tank. A compact kit-of-parts for assembling the aforementioned appliance and respective method using the aforementioned appliance for recycling organic waste into biogas and liquid fertilizer are described.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: January 9, 2024
    Inventors: Oshik Moshe Efrati, Yair Teller, Erez Lanzer, Shoham Zak
  • Patent number: 11866382
    Abstract: The present invention relates to improving the efficacy of man-made and/or natural organic-based animal manure fertilizers by administration of an organic solvent formula containing polyorganic acids and/or their salts. The formulation liberates nutrient(s) that are normally bound in the soil as insoluble salts and complexes. These delivery formulations also provide an environmentally sound and inherently safe solvating system that improves diffusion of polyorganic acids to the granule fertilizer. These delivery formulations enable safe storage, transport and subsequent application or blending with solid or liquid fertilizers. The combined formulation and fertilizer can be applied to soil to provide improved efficacy of fertilizer by liberating nutrients bound in the soil for uptake by plant life.
    Type: Grant
    Filed: July 20, 2021
    Date of Patent: January 9, 2024
    Assignee: SOILGENIC TECHNOLOGIES, LLC
    Inventors: Gary David McKnight, Randall Linwood Rayborn
  • Patent number: 11866383
    Abstract: A nitrification inhibiting composition for use in agricultural applications includes from about 5% to about 15% propylene glycol methyl ether and from about 20% to about 35% dicyandiamide. The nitrification inhibiting composition may be combined with a fertilizer and applied to plants or soil to increases the effectiveness of the fertilizer, thereby positively impacting crop yield and quality.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: January 9, 2024
    Assignee: SYNSUS PRIVATE LABEL PARTNERS, LLC
    Inventors: Douglas Hocking, Robert Munion
  • Patent number: 11866384
    Abstract: Compositions include dicyandiamide (DCD), N-(N-butyl) Thiophosphoric Triamide (NBPT), and styrene-maleic anhydride copolymer in a solution. Agricultural fertilizer compositions contain the DCD, NBPT and styrene-maleic anhydride copolymer composition in combination with a fertilizer.
    Type: Grant
    Filed: August 12, 2021
    Date of Patent: January 9, 2024
    Assignee: SYNSUS PRIVATE LABEL PARTNERS, LLC
    Inventors: Douglas Hocking, Robert Munion
  • Patent number: 11866385
    Abstract: A coating composition comprising an adduct formed by chemical reaction of a monomer containing poly-thiol with a monomer containing one or more unsaturated carbon-carbon bond; more particularly relates to coated agrochemical compositions coated with said coating composition.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: January 9, 2024
    Assignee: EVERRIS INTERNATIONAL B.V.
    Inventors: Evgeniy Tkalya, Ronald Petrus Johannes Gosens, Susan Tine Kathelyne Sijstermans, Michael Ernest Josephina Hendriks, Martin Anna Fransiscus Jacobus. Marx, Karina Rabe, Gerardus Jacobus Joseph Out
  • Patent number: 11866386
    Abstract: A method of reducing an aromatic ring or a cyclic, allylic ether in a compound includes preparing a reaction mixture including a compound including an aromatic moiety or a cyclic, allylic ether moiety, an alkali metal, and either ethylenediamine, diethylenetriamine, triethylenetetramine, or a combination thereof, in an ether solvent; and reacting the reaction mixture at from ?20° C. to 30° C. for a time sufficient to reduce a double bond in the aromatic moiety to a single bond or to reduce the cyclic, allylic ether moiety.
    Type: Grant
    Filed: September 17, 2021
    Date of Patent: January 9, 2024
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Kazunori Koide, James Proviano Burrows
  • Patent number: 11866387
    Abstract: A process for producing methacrylic acid or a methacrylic acid ester including, producing acrolein, reacting the produced acrolein with hydrogen to produce propanal, reacting the propanal with formaldehyde to produce methacrolein, and oxidizing the methacrolein in the presence of an oxygen containing gas and optionally an alcohol, to methacrylic acid or a methacrylic acid ester.
    Type: Grant
    Filed: July 11, 2019
    Date of Patent: January 9, 2024
    Assignee: Röhm GmbH
    Inventors: Alexander May, Steffen Krill, Marcel Treskow, Diego Carambia, Gabriel Avella
  • Patent number: 11866388
    Abstract: Catalyst systems suitable for tetramerizing ethylene to form 1-octene may include a catalyst having a structure according to Formula (VI) or Formula (VII). In Formulas (VI) and (VII), X is a halogen, a (C2-C30) carboxylate, acetylacetonate, or a (C1-C30) hydrocarbyl; L1 is a neutral coordinating ligand; n is an integer from 0 to 6; Y is a (C6-C20)fluorine-substituted aryl, a (C6-C20)fluorine-substituted aryloxy, or a (C1-C20)fluorine-substituted alkoxy; and L?L is a bidentate chelating ligand. The catalyst system may also include an aluminum containing agent which includes a reaction product of an organoaluminum compound and an antifouling compound. The antifouling compound may include one or more organic acids, organic acid salts, esters, anhydrides, or combinations of these.
    Type: Grant
    Filed: February 8, 2023
    Date of Patent: January 9, 2024
    Assignee: SAUDI ARABIAN OIL COMPANY
    Inventors: Sohel Shaikh, Motaz Khawaji, Wei Xu
  • Patent number: 11866389
    Abstract: According to embodiments, a process of forming a catalyst for aromatizing hydrocarbons may include enhancing a mesoporosity of a zeolite support by a base-leaching treatment, an acid-leaching treatment, or both to form a zeolite support having enhanced mesoporosity, mixing the zeolite support having enhanced mesoporosity with a solution containing zinc or gallium to disperse the zinc or gallium on the zeolite support having enhanced mesoporosity, and calcining the zeolite support having enhanced mesoporosity with zinc or gallium dispersed thereon to form a zinc- or gallium-doped zeolite catalyst having a mesopore volume of greater than 0.09 cm3/g and less than 0.20 cm3/g.
    Type: Grant
    Filed: September 7, 2022
    Date of Patent: January 9, 2024
    Assignees: Saudi Arabian Oil Company, King Fahd University of Petroleum and Minerals
    Inventors: Yaming Jin, Ziyauddin S. Qureshi, Abdullah M. Aitani, Omer Refa Koseoglu, Mohammad Naseem Akhtar, Hassan Saeed Al-Awad Alasiri
  • Patent number: 11866390
    Abstract: The present disclosure provides compounds useful as anesthetics, such as topical anesthetics, of general formula (VIIIi): wherein: R2?H or Me; R3?H or Me; R4=Alkyl; R5?O-Alkyl; and Alkyl=aliphatic C1-C4 alkyl. The present disclosure further provides methods of making compounds of general formula (VIIIi), compositions comprising a therapeutically effective amount of a compound of general formula (VIIIi), and methods of treating or preventing pain in a subject by administering (e.g., topically applying) compositions comprising an effective amount of a compound of general formula (VIIIi) to the subject.
    Type: Grant
    Filed: July 25, 2023
    Date of Patent: January 9, 2024
    Assignee: PTC Innovations, LLC
    Inventors: Pendleton Wickersham, Stephen Bendel, Todd Mathis, Christian Warren
  • Patent number: 11866391
    Abstract: The present disclosure provides compounds useful as anesthetics, such as topical anesthetics, of general formula (VIIIk): wherein: R2?H or Me; R3?H or Me; R4=Alkyl; R5?O-Alkyl; and Alkyl=aliphatic C1-C4 alkyl. The present disclosure further provides methods of making compounds of general formula (VIIIk), compositions comprising a therapeutically effective amount of a compound of general formula (VIIIk), and methods of treating or preventing pain in a subject by administering (e.g., topically applying) compositions comprising an effective amount of a compound of general formula (VIIIk) to the subject.
    Type: Grant
    Filed: July 25, 2023
    Date of Patent: January 9, 2024
    Assignee: PTC Innovations, LLC
    Inventors: Pendleton Wickersham, Stephen Bendel, Todd Mathis, Christian Warren
  • Patent number: 11866392
    Abstract: The present disclosure provides compounds useful as anesthetics, such as topical anesthetics, of general formula (XIII): wherein: R8=NH2, NH(Me), N(Me)2, The present disclosure further provides methods of making compounds of general formula (XIII), compositions comprising a therapeutically effective amount of a compound of general formula (XIII), and methods of treating or preventing pain in a subject by administering (e.g., topically applying) compositions comprising an effective amount of a compound of general formula (XIII) to the subject.
    Type: Grant
    Filed: July 26, 2023
    Date of Patent: January 9, 2024
    Assignee: PTC Innovations, LLC
    Inventors: Pendleton Wickersham, Stephen Bendel, Todd Mathis, Christian Warren
  • Patent number: 11866393
    Abstract: Disclosed are 7,7?-dihalo-3,3,3?,3?-tetramethyl-1,1?-spirobiindane and a preparation method thereof. The 7,7?-dihalo-3,3,3?,3?-tetramethyl-1,1?-spirobiindane is a compound represented by formula I, or an enantiomer, a raceme or a diastereomer thereof. The compound of formula I could be prepared by using a racemic or optically active 3,3,3?,3?-tetramethyl-1,1?-spirobiindane-6,6?-diol as a raw material through a series of reactions. The 7,7?-dihalo-3,3,3?,3?-tetramethyl-1,1?-spirobiindane is a key intermediate for preparing 3,3,3?,3?-tetramethyl-1,1?-spirobiindane-based phosphine ligand compounds represented by formula II or III.
    Type: Grant
    Filed: March 22, 2022
    Date of Patent: January 9, 2024
    Assignee: Zhejiang University
    Inventors: Xufeng Lin, Linxi Yao, Shirui Chang, Lei Wang
  • Patent number: 11866394
    Abstract: Prodrugs of hydroxamate-based GCPII inhibitors and methods of their use for treating a disease or condition are disclosed.
    Type: Grant
    Filed: July 12, 2021
    Date of Patent: January 9, 2024
    Assignees: THE JOHNS HOPKINS UNIVERSTY, INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY AS CR V.V.I.
    Inventors: Barbara Slusher, Rana Rais, Jan Vavra, Tomas Tichy, Pavel Majer, Andrej Jancarik, Lukas Tenora
  • Patent number: 11866395
    Abstract: A method of producing petrochemicals using a hydrocarbon fuel cell includes the steps of operating the fuel cell to produce electricity, thermal energy, and one or more exhaust stream, the one or more exhaust stream comprising at least a carbon-containing gas and water, reacting at least a portion of the exhaust stream with the reactant stream of natural gas to produce one or more petrochemical streams in a reactor, and heating one or more reactants using at least a portion of at least one of the electricity and the thermal energy.
    Type: Grant
    Filed: February 7, 2019
    Date of Patent: January 9, 2024
    Assignees: 1304338 Alberta Ltd., 1304342 Alberta Ltd.
    Inventors: Jose Lourenco, MacKenzie Millar
  • Patent number: 11866396
    Abstract: The present invention relates to an NCC process and an apparatus for producing light olefins and aromatics, wherein the C5+ fraction (16) of the cracking effluent is separated into a C5 fraction (25) recycled into the NCC reactor (4) and a C6+ fraction (26), and wherein the C6+ fraction (26) is sent into an aromatics extraction unit (30) to produce an aromatics-enriched fraction (31) and a low-aromatics fraction (32).
    Type: Grant
    Filed: December 15, 2020
    Date of Patent: January 9, 2024
    Assignee: IFP ENERGIES NOUVELLES
    Inventors: Olivier Thinon, Anne Claire, Vania Santos-Moreau
  • Patent number: 11866397
    Abstract: A process for upgrading a hydrocarbon feed to produce light olefins, includes contacting the hydrocarbon feed with steam in the presence of a cracking catalyst in a steam catalytic cracking reactor at reaction conditions sufficient to cause at least a portion of the hydrocarbons in the hydrocarbon feed to undergo one or more cracking reactions to produce a steam catalytic cracking effluent comprising ethylene, propylene, or both, wherein the process is capable of being transitioned between an ethylene-selective mode and a propylene-selective mode; determining whether to produce ethylene or propylene; when producing ethylene, then operating the process in ethylene-selective mode comprises producing more ethylene than propylene; or when producing propylene, then operating the process in propylene-selective mode comprises producing more propylene than ethylene.
    Type: Grant
    Filed: March 14, 2023
    Date of Patent: January 9, 2024
    Assignee: SAUDI ARABIAN OIL COMPANY
    Inventors: Mohammed Z. Albahar, Emad N. Al-Shafei, Mohammed F. Aljishi, Ali N. Aljishi, Ali S. Alnasir
  • Patent number: 11866398
    Abstract: This invention relates generally to the synthesis of ?12-Prostaglandin J product using stereoretentive ruthenium olefin metathesis catalysts supported by dithiolate ligands. ?12-Prostaglandin J products were generated with excellent selectivity (>99% Z) and in moderate to high/good yields (47% to 80% yield; 58% to 80% yield).
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: January 9, 2024
    Assignee: California Institute of Technology
    Inventors: Jiaming Li, Xu Chen, Tonia S. Ahmed, Brian M. Stoltz, Robert H. Grubbs
  • Patent number: 11866399
    Abstract: Process for hydroformylation of olefins using Pt and bromine.
    Type: Grant
    Filed: December 13, 2022
    Date of Patent: January 9, 2024
    Assignee: EVONIK OPERATIONS GMBH
    Inventors: Carolin Schneider, Ralf Jackstell, Matthias Beller, Robert Franke
  • Patent number: 11866400
    Abstract: Process for hydroformylation of olefins using Pt and DPEphos.
    Type: Grant
    Filed: December 13, 2022
    Date of Patent: January 9, 2024
    Assignee: EVONIK OPERATIONS GMBH
    Inventors: Carolin Schneider, Ralf Jackstell, Matthias Beller, Robert Franke
  • Patent number: 11866401
    Abstract: A salicyl fumarate derivative having the general structural formula (A): In the structural formula (A), R1 is one of H+, Na+, K+or NH4+. R2 is one of fumaric acid ester products. The derivative has the general structural formula of the combination of salicylic acid and fumaric acid through an esterification reaction. This category of compounds possesses good effects in treatment of neurodegenerative diseases.
    Type: Grant
    Filed: November 27, 2020
    Date of Patent: January 9, 2024
    Assignee: CHONGQING NEUROPARK BIOSCIENCE CO., LTD.
    Inventors: Lichuan Yang, Bobby Thomas, Mingyue Guo
  • Patent number: 11866402
    Abstract: The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
    Type: Grant
    Filed: April 30, 2021
    Date of Patent: January 9, 2024
    Assignee: Corsair Pharma, Inc.
    Inventors: Xiaoming Zhang, Meenakshi S. Venkatraman, Cyrus K. Becker
  • Patent number: 11866403
    Abstract: The present invention provides a carboxylic acid ester compound represented by formula (1) that is useful as a fragrance component or as a formulated fragrance material, wherein R1 is —COOR, wherein R is an alkyl group having 1 to 4 carbon atoms.
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: January 9, 2024
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Yutaka Matsuura, Tomohiko Hakamata
  • Patent number: 11866404
    Abstract: The present disclosure relates to the formation of terephthalate esters.
    Type: Grant
    Filed: June 17, 2021
    Date of Patent: January 9, 2024
    Assignee: 9449710 CANADA INC.
    Inventors: Adel Essaddam, Fares Essaddam
  • Patent number: 11866405
    Abstract: The present application relates to chemical compounds of Formula (A): and pharmaceutically acceptable salts thereof, wherein X, R1, and R2 are as defined herein. The chemical compounds of Formula (A) inhibit IRAK4 and consequently have potential utility in medicine.
    Type: Grant
    Filed: December 1, 2021
    Date of Patent: January 9, 2024
    Assignee: AstraZeneca AB
    Inventors: Ina Terstiege, Stefan Schiesser, Yafeng Xue, Hui-Fang Chang, Anna Ingrid Kristina Berggren
  • Patent number: 11866406
    Abstract: This disclosure describes compounds of Formula (I), stereoisomers, side compounds thereof, pharmaceutical compositions and methods of manufacturing such compounds, using silylation reagents and producing compositions and products made using such methods. More particularly, this disclosure describes manufacture of trofinetide and side products, compositions and products containing such compounds, for pharmaceutical uses to treat neurodegenerative or neurodevelopmental disorders.
    Type: Grant
    Filed: June 23, 2022
    Date of Patent: January 9, 2024
    Assignee: NEUREN PHARMACEUTICALS LIMITED
    Inventors: Clive Blower, Mathew Peterson, James Murray Shaw, James Anthony Bonnar, Etienne David Frank Philippe Moniotte, Martin Bernard Catherine Bousmanne, Cecilia Betti, Karel Willy Luc Decroos, Mimoun Ayoub
  • Patent number: 11866407
    Abstract: This invention is in the field of medicinal chemistry and relates to a new class of small-molecules having a pyrrolidinone-acetamide (or similar) structure (e.g., Formula I) which function as inhibitors of the SARS-CoV-2 papain-like protease (PLpro), which function as inhibitors of the SARS-CoV-2 related viral 3CL protease (MPpro), which function as therapeutics for the treatment of viral infection characterized with PLPpro and/or Mpro protease activity and/or expression (e.g., COVID-19), and which function as therapeutics for the treatment of other conditions characterized with PLPpro and/or Mpro protease activity and/or expression.
    Type: Grant
    Filed: April 19, 2022
    Date of Patent: January 9, 2024
    Assignee: Arizona Board of Regents on Behalf of the University of Arizona
    Inventor: Jun Wang
  • Patent number: 11866408
    Abstract: Described herein are compounds that are derivatives of DMT or 5-MeO-DMT and can be metabolically converted to N,N-dimethyltryptamine or analogs thereof upon administration to a subject. In certain embodiments, the compounds described herein are useful for the treatment of conditions associated with a neurological disease.
    Type: Grant
    Filed: February 23, 2023
    Date of Patent: January 9, 2024
    Assignee: TERRAN BIOSCIENCES INC.
    Inventors: Matthew Alexander James Duncton, Sam Clark
  • Patent number: 11866409
    Abstract: Provided are ARTS mimetic compounds that act as novel antagonists for XIAP and Bcl-2. Further, the novel ARTS mimetic compounds of the presently claimed subject matter induce apoptosis and/or differentiation in premalignant and malignant cells and thereby restore their normal-like phenotype. Further provided are compositions, methods and uses of said ARTS mimetic compounds in the treatment of cancer and premalignant conditions.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: January 9, 2024
    Assignee: CARMEL-HAIFA UNIVERSITY ECONOMIC CORPORATION LTD.
    Inventors: Sarit Larisch, Dalit Barkan
  • Patent number: 11866410
    Abstract: The present invention relates to a new process for manufacturing (6aR,10aR)-7-propyl-6,6 a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4?,5?:5,6]benzo[1,2-g]quinoline with formula (Ib) below, (4aR,10aR)-1-Propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinoline-6,7-diol with formula (I) below and salts thereof. Both compounds are for use in the treatment of neurodegenerative diseases and disorders such as Parkinson's Disease. The invention also relates to new intermediate compounds of said process.
    Type: Grant
    Filed: October 7, 2021
    Date of Patent: January 9, 2024
    Assignee: H. Lundbeck A/S
    Inventors: Mikkel Fog Jacobsen, Martin Juhl, Kåre Søndergaard
  • Patent number: 11866411
    Abstract: Compounds and compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.
    Type: Grant
    Filed: March 8, 2021
    Date of Patent: January 9, 2024
    Assignee: Agios Pharmaceutical, Inc.
    Inventors: Francesco G. Salituro, Jeffrey O. Saunders, Shunqi Yan
  • Patent number: 11866412
    Abstract: Novel acridin-9-one derivative compounds having broad spectrum antibacterial activity, a method of making said compounds, methods of using said compounds, and a pharmaceutical composition comprising said compound(s) are provided. The acridin-9-one compounds have antimicrobial activity against various susceptible and resistant gram-positive and gram-negative bacteria as well as drug resistant bacteria. They act as DNA gyrase and topoisomerase IV inhibitors and are satisfiable as a drug for infectious treatment.
    Type: Grant
    Filed: March 3, 2023
    Date of Patent: January 9, 2024
    Assignee: KING FAISAL UNIVERSITY
    Inventors: Christophe Tratrat, Michelyne Haroun
  • Patent number: 11866413
    Abstract: Disclosed is a method for refining 5-fluorouracil, comprising the following steps: dissolving 5-fluorouracil in an organic solvent, preferably DMSO, heating and stirring until dissolved; naturally cooling the filtrate until a crystal is precipitated; filtering, washing a filter cake using a polar solvent, and draining and drying under reduced pressure. By using the new refining method, the content of impurities in 5-fluorouracil may be reduced to less than 0.01%, the product purity is more than 99.98%, and the refining yield is higher than 70%. In addition, the refining method of the present invention has a simple process, convenient operation, low production costs, high product purity, a stable process, and is suitable for industrial production.
    Type: Grant
    Filed: January 10, 2020
    Date of Patent: January 9, 2024
    Assignee: SHANGHAI XUDONG HAIPU PHARMACEUTICAL CO., LTD
    Inventors: Xiaolin Chen, Pengfei Gao, Yike Yang, Yi Liang, Yafeng Zhan
  • Patent number: 11866414
    Abstract: There are disclosed compounds of the following formula I: or a stereoisomer or pharmaceutically acceptable salt thereof, wherein all substituents are as defined herein, which are useful in the modulation of IL-12, IL-23 and/or IFN?, by acting on Tyk-2 to cause signal transduction inhibition. The compounds of the invention may be useful for treating neurodegenerative diseases or disorders.
    Type: Grant
    Filed: May 13, 2022
    Date of Patent: January 9, 2024
    Assignee: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Steven H. Spergel, Ryan M. Moslin, Michael Edward Mertzman, Zili Xiao
  • Patent number: 11866415
    Abstract: Provided herein is a method of forming a beta-lactone from a carboxylic acid having a beta-carbon with a hydrogen atom disposed thereon. The method comprises contacting a carboxylic acid of formula (1) as described herein with an effective amount of a palladium(II) catalyst, an effective amount of an N-protected aminoacid ligand, and t-butylhydroperoxide in a solvent comprising hexafluoroisopropanol (HFIP), at about 60° C. to provide a beta-lactone of formula (2) as described herein.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: January 9, 2024
    Assignee: The Scripps Research Institute
    Inventors: Jin-quan Yu, Zhe Zhuang
  • Patent number: 11866416
    Abstract: The present invention is related to the inhibition of the formation of Streptococci biofilms through the inhibition of glucosyl transferase (Gtf). Compounds, compositions and methods for inhibiting Streptococcus biofilm formation, as well as for preventing, inhibiting and/or treating the formation of dental caries, and methods of identifying compounds that prevent, inhibit and/or treat the formation of dental caries are provided.
    Type: Grant
    Filed: April 3, 2019
    Date of Patent: January 9, 2024
    Assignee: UAB Research Foundation
    Inventors: Sadanandan E. Velu, Hui Wu, Qiong Zhang, Bhavitavya Nijampatnam
  • Patent number: 11866417
    Abstract: Provided herein is a crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione hemihydrate. Pharmaceutical compositions comprising the crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione hemihydrate are also disclosed.
    Type: Grant
    Filed: October 1, 2020
    Date of Patent: January 9, 2024
    Assignee: Celgene Corporation
    Inventor: Jerry Lee Atwood
  • Patent number: 11866418
    Abstract: Disclosed are compounds of formulae I and II, and pharmaceutically acceptable salts and prodrugs thereof, which are inhibitors of the complement system. Also provided are pharmaceutical compositions comprising such a compound, and methods of using the compounds and compositions in the treatment or prevention of a disease or condition characterized by aberrant complement system activity.
    Type: Grant
    Filed: April 27, 2022
    Date of Patent: January 9, 2024
    Assignee: BioCryst Pharmaceuticals, Inc.
    Inventors: Pravin L. Kotian, Yarlagadda S. Babu, Weihe Zhang, Peng-Cheng Lu, Minwan Wu, Wei Lv, Trung Xuan Nguyen, Zhao Dang, Venkat R. Chintareddy, V. Satish Kumar, Krishnan Raman
  • Patent number: 11866419
    Abstract: The present invention relates to the following compounds wherein the integers are as defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of tuberculosis.
    Type: Grant
    Filed: September 17, 2021
    Date of Patent: January 9, 2024
    Assignee: Janssen Sciences Ireland Unlimited Company
    Inventors: Jérôme Émile Georges Guillemont, Magali Madeleine Simone Motte, Pierre Jean-Marie Bernard Raboisson, Abdellah Tahri
  • Patent number: 11866420
    Abstract: The present invention relates to novel hydrochloride salt forms of N-(2?,4?-difluoro-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-[1,1?-biphenyl]-3-yl)cyclopropanesulfonamide (I). Compound (I) is a selective inhibitor of FGFR/VEGFR kinase families and is useful in the treatment of cancer.
    Type: Grant
    Filed: September 5, 2019
    Date of Patent: January 9, 2024
    Assignee: Aurigene Oncology Limited
    Inventors: David Jonaitis, Oskari Karjalainen
  • Patent number: 11866421
    Abstract: Pyrimidine and Pyridine containing compounds are described herein that are enzyme p70S6K inhibitors useful in the treatment of S6K-dependent or S6K-mediated diseases and conditions, including but not limited to cancer, fibrotic metabolic and certain neurological disorders.
    Type: Grant
    Filed: May 31, 2021
    Date of Patent: January 9, 2024
    Assignee: Epigen Biosciences, INC.
    Inventors: Graham Beaton, Fabio Tucci, Satheesh Ravula, Suk Joong Lee, Chandravadan Shah