Abstract: The objective of the present invention is to take advantage of new and improved processes and catalysts that can facilitate the efficient, direct CO2 conversion (CO2C) reaction to e-methane at temperatures less than about 350° C. in one step.

Abstract: Processes for upgrading a hydrocarbon-containing feed. The feed and a first particle stream can be contacted under pyrolysis conditions to effect pyrolysis of the feed to produce a pyrolysis effluent that can include olefins and the particles, where coke can be formed on the particles. A first gaseous stream and a second particle stream can be obtained from the pyrolysis effluent. At least a portion of the first gaseous stream can be contacted with oligomerization catalyst particles under oligomerization conditions to effect oligomerization of at least a portion of olefins in the first gaseous stream.

Abstract: Exemplary systems and methods process gas streams comprising methane. Exemplary reactors receive a gas stream and comprise catalyst material in a reaction zone. Non-thermal plasma may be generated in the reaction zone. A temperature of the reaction zone may be maintained within a predetermined temperature range. Products may be collected from a reactor outlet.

Abstract: Provided is a continuous process for converting waste plastic into recycle for polyethylene polymerization. The process comprises selecting waste plastics containing polyethylene and/or polypropylene and preparing a blend of a bio feedstock and the selected plastic. The amount of plastic in the blend comprises no more than 20 wt. % of the blend. The blend is passed to a FCC unit. A liquid petroleum gas LPG olefin/paraffin mixture and naphtha are recovered from the FCC unit and can be passed on to make polyethylene.

Abstract: Disclosed is oligomerization of ethylene to form 1-hexene in combination with aromatization of the 1-hexene formed by oligomerization, to form benzene.

Abstract: The present invention relates to the field of organic synthesis. More specifically, it concerns a process for the selective reduction of a C3-C70 substrate containing one or more carbonyl or carboxylic functional groups into the corresponding 5 alcohol diol, or polyalcohol in the presence of a silane and at least one catalyst or pre-catalyst in the form of a zinc complex. The Zinc complex of formula (I) or (II) is also part of the invention.

Abstract: This method produces methanol with reduced dependency on fossil fuel. The method includes: a gas acquisition step of acquiring a gas (G1) containing hydrogen by a pyrolysis reaction and/or a dehydrogenation reaction of a hydrocarbon; and a conversion step of converting at least part of the gas (G1), and a source gas containing (G2) carbon oxide into methanol. In the conversion step, the reaction is allowed to proceed by condensing a high boiling point component containing converted methanol and water, and discharging the high boiling point component condensed to the outside of the reaction system.

Abstract: Process for the preparation of dicidal.

Abstract: A method of separating phenol can include: separating a first portion of acetone from a product stream in an evaporator unit, wherein the first portion of the acetone includes recycle acetone and bypass acetone; recycling the recycle acetone; withdrawing a bottom fraction from the evaporator unit; neutralizing the bottom fraction to form a distillation feed stream that is directed to a distillation column; separating the distillation feed stream into a bottom stream and an overhead stream, the bottom stream including a crude phenol fraction; passing the overhead stream through a condenser to produce a distillate as a crude acetone fraction, and wherein reflux ratio of the distillation column is less than or equal to 0.40, with the reflux ratio a ratio of a weight of a reflux to distillate weight; and directing the bypass acetone around the distillation column.

Abstract: The present invention relates to a compound having general formula I for use in the activation of AMPK. A composition comprising said compound and methods for use thereof, in the activation of AMPK, are also provided.

Abstract: The invention provides methods for preparing and purifying compounds which can be used as environmentally compatible detergents, and compounds obtainable by such methods.

Abstract: A process for preparing aldehydes from methanol includes introducing a feed stream comprising methanol and hydrogen gas into a reaction zone of a first reactor, converting the feed stream into an intermediate stream comprising C2 to C4 olefins in the reaction zone in the presence of a first catalyst, wherein the first catalyst is a microporous catalyst component, removing water and species C4 and heavier from the intermediate stream to form a lights stream, and converting the lights stream into a product stream comprising propionaldehyde in the presence of a second catalyst and carbon monoxide in a second reactor. The propionaldehyde can further be converted to methyl methacrylate via oxidative esterification.

Abstract: A process for preparing aldehydes from synthesis gas includes introducing a first feed stream comprising hydrogen gas and a carbon-containing gas comprising carbon monoxide into a reaction zone of a first reactor, converting the first feed stream into a first product stream comprising C2 to C4 hydrocarbons in the reaction zone in the presence of a first catalyst, wherein the first product stream further comprises carbon dioxide, removing water and C4 and higher hydrocarbons from the first product stream to form a second feed stream, and converting the second feed stream into a second product stream comprising propionaldehyde in the presence of a second catalyst in a second reactor. The propionaldehyde can further be converted to methyl methacrylate via oxidative esterification.

Abstract: Process for preparing the dialdehyde of vinylcyclohexene

Abstract: A method for preparing 3-hydroxy-3-methylbutyric acid (HMB) or salts thereof from tertbutanol and carbon monoxide, may include reacting tert-butanol in an aqueous mixture with carbon monoxide under electrolytic conditions. The electrolytic conditions may include applying an electric potential to the aqueous reaction mixture in a range of from 1.5 and 25 V and/or operating electrodes at a current density in a range of from 1 to 10.000 A/m2. The electric potential may be applied to the aqueous mixture using a diamond anode and/or a steel cathode. The reaction may be conducted in the presence of at least one conducting electrolyte.

Abstract: A method for synthesizing a labeled pyruvic acid is provided. An isopropenyl Grignard reagent is added to a reaction vessel and cooled to a preset temperature. A carbon isotope-labeled carbon dioxide is added to the reaction vessel and continuously reacted with the isopropenyl Grignard reagent for a preset time. The reaction system is added with an acid and adjusted to a preset temperature to quench the reaction. The reaction system is subjected to ozonization, and reduced in the presence of a reducing agent. Impurities are removed to obtain the labeled pyruvic acid.

Abstract: A process for preparing C2 to C4 carboxylic acids from synthesis gas includes introducing a feed stream comprising hydrogen gas and a carbon-containing gas comprising carbon monoxide into a reaction zone of a first reactor, converting the feed stream into an intermediate stream comprising C2 to C4 hydrocarbons in the reaction zone in the presence of a first catalyst, wherein the intermediate stream further comprises carbon dioxide and wherein the first catalyst is a composite catalyst comprising a metal oxide catalyst component and a microporous catalyst component, and converting the intermediate stream into a product stream comprising C2 to C4 carboxylic acids in the presence of a second catalyst in a second reactor. The second reactor can be configured for olefin oxidation or paraffin oxidation.

Abstract: A process for the preparation of a color stable C6-12 saturated aliphatic carboxylic acid in which (1) the corresponding aldehyde is oxidized with molecular oxygen to obtain the crude saturated aliphatic carboxylic acid in a liquid mixture, (2) molecular oxygen removed from the crude saturated aliphatic carboxylic acid mixture, and (3) the saturated aliphatic carboxylic acid separated from the molecular oxygen depleted mixture by distillation as a color stable product.

Abstract: Provided is a method for obtaining high-quality products safely and stably. The present invention relates to a method for producing a compound, the method including feeding a slurry containing crystals of the compound to a hydraulic wash column; melting crystals in a crystal-containing circulation slurry discharged from the hydraulic wash column; discharging a mother liquor using a filter from the crystal-containing slurry in the hydraulic wash column; and introducing a liquid having a temperature equal to or higher than the temperature of the mother liquor immediately after being discharged in the mother liquor discharging step into a nozzle attached to the hydraulic wash column from outside the hydraulic wash column, the nozzle being other than a nozzle at a return port for a circulation liquid containing a melt obtained in the melting and a pipe that feeds the crystal-containing slurry to the hydraulic wash column.

Abstract: Provided is a method for purifying a compound capable of providing a high purity compound in high yield and at low cost. The present invention relates to the method for purifying a compound using a purification apparatus, the purification apparatus including: a crystallizing unit including a crystal forming section; and a wash column including a mechanism that forcibly transfers crystals. The crystallizing unit includes N tanks connected in series, wherein N is 2 or greater, a 1st tank is a most downstream tank, a (N)th tank is a most upstream tank, at least the 1st tank is a crystallization tank including a cooling mechanism, and a 2nd and subsequent tanks are each a crystallization tank or a ripening tank. The purification apparatus includes a line that feeds a compound-containing liquid to be purified to at least one of the N tanks.

Abstract: The present invention aims to provide a compound purification apparatus capable of providing a high purity compound in high yield and at low cost.

Abstract: The disclosure provides methods of synthesizing very long chain fatty acids, including deuterated very long chain fatty acids. The fatty acids can by polyunsaturated fatty acids. The methods include the step of reacting a protected leaving group (L)-substituted saturated aliphatic group with a halo-substituted unsaturated aliphatic group to form a protected aliphatic group. The protected aliphatic group is deprotected to form an alcohol. The alcohol is then oxidized, thereby forming a very long chain fatty acid.

Abstract: The present disclosure is directed to compounds having Formula (I) and their enantiomers, wherein the definitions of R, Y1, Y2, W, X, Z, and n are provided in the disclosure. The disclosure is also directed to pharmaceutical compositions of the disclosed compounds, as well as their use for treatment of thrombosis and related conditions and complications.

Abstract: The present invention relates to a process for the continuous preparation of (meth)acrylate by reacting an alcohol with a (meth)acrylic acid using at least one control unit which is closed-loop controlled by a sensor (S).

Abstract: An improved process for synthesizing methacrylic acid and/or alkyl methacrylates, in particular methyl methacrylate (MMA), involves reacting acetone and hydrogen cyanide in the presence of an alkaline catalyst in a first reaction stage such that a first reaction mixture containing acetone cyanohydrin (ACH) is obtained. The process then involves working up the first reaction mixture containing acetone cyanohydrin (ACH), reacting acetone cyanohydrin (ACH) and sulfuric acid in a second reaction stage (amidation), and heating the second reaction mixture in a third reaction stage (conversion), such that methacrylamide (MAA) is obtained. The process further involves hydrolyzing or esterifying methacrylamide (MAA) with water and, optionally, alcohol, preferably water and optionally methanol, in a fourth reaction stage such that methacrylic acid or alkyl methacrylate is formed. The sulfuric acid used has a concentration of 98.0 wt % to 100.0 wt %.

Abstract: Through an intermediate I (a compound having the structural formula as shown in the formula Ia and/or the formula Ib), or a pharmaceutically acceptable salt thereof, or a solvate thereof, and a tautomer Ic of Ib, a bicyclopyrone intermediate II with a high yield can be prepared. Two compounds are docked first under the action of a base to produce an intermediate I, and then the intermediate I is subjected to intramolecular ring closure by an ammonium salt, which can increase the yield of the bicyclopyrone intermediate (II), reduce side reactions, and reduce problems that a reaction of raw materials is easily incomplete due to intramolecular ring closure directly through an ammonium salt. A one-pot method includes producing an intermediate I under the action of a base and then performing a ring-closure reaction to produce a bicyclopyrone intermediate (II) that reduces side reactions, and further increases the yield.

Abstract: The invention relates to compounds of formula (I) and to their use in treating or preventing an inflammatory disease or a disease associated with an undesirable immune response: wherein R, R1, R2 and RB are as defined herein.

Abstract: The present invention relates to a process for producing L-phenylalanine ester which comprises the reaction of L-phenylalanine with an alcohol in the presence of thionyl chloride.

Abstract: Disclosed is a kettle-type continuous production method for glycine. The method includes: performing a hydantoin synthesis and hydrolysis reaction on glycolonitrile, ammonium carbonate, ammonium bicarbonate and water in a reactor with multiple serially connected kettles, and then purifying, concentrating, crystallizing, separating and drying the products to obtain refined glycine. The reactor with multiple serially connected kettles consists of a hydantoin synthesis section and a hydantoin hydrolysis section which are connected in sequence, the hydantoin synthesis section including a first reaction kettle group of reaction kettles with a reaction temperature of 80-100° C. and a second reaction kettle group of reaction kettles with a reaction temperature of 100-120° C.

Abstract: The present disclosure relates to PEG-lipids, cationic and/or ionizable lipids and nucleic acid-lipid particle compositions comprising the same. The present disclosure also relates to methods of making, using and delivering the described lipids and lipid-containing particles.

Abstract: The present invention relates to a compound of the following formula (I): in particular for use in a method for preventing or treating a disease in an individual, more particularly for preventing or treating a disease is associated to progerin or to prelamin A.

Abstract: A method for preparing guanidino acetic acid involves reacting cyanamide and glycine in an aqueous reaction mixture in the presence of a base. The ammonia content in the reaction mixture is controlled to be below 20 g/L, and the dicyandiatrade content in the reaction mixture is kept below 5 wt.-%.

Abstract: The present technology relates to thiol functionalized conductors which can be grafted onto polymers and methods for making same. In certain embodiments, the thiol functionalized conductors can be grafted onto polymers with low Tg to synthesize single-ion conducting polymer electrolytes (SIPE) having improved conductivity. The thiol functionalized conductor compound comprises a covalently attached sulfonimide anion on one end, which is associated with a monovalent cation; 1-3 hydrocarbon chains as the linker (L); 0-2 functional groups (R); and a thiol group on the other end of the compound.

Abstract: The disclosure provides a novel process and synthetic intermediates for making belzutifan, a HIF-2a inhibitor, useful for the treatment of certain VHL-related indications and cancer.

Abstract: Modular dendrimers with cationic groups and lipophilic groups are provided herein. In some aspects, the dendrimers provided herein may be formulated in compositions which contain a nucleic acid and one or more helper excipients. In some aspects, these compositions may also be used to treat diseases or disorders with a therapeutic nucleic acid.

Abstract: The present invention provides a method for separating a compound represented by Formula (1) or (2) [in the formula, P1 is a hydrogen atom or a protective group of a hydroxyl group, R1 is a linear or branched C1-6 alkyl group that may be substituted with a phenyl group, A is an alkenylene group, and R2 is a hydroxyl group, a C1-3 alkoxy group, a mono(C1-3 alkyl)amino group, or a di(C1-3 alkyl)amino group] from a geometrical isomer thereof, in which the geometrical isomer is a geometrical isomer in a double bond included in A, the method including processing a mixture containing the compound and the geometrical isomer thereof by a chromatographic method using an acidic functional group-modified silica gel as a stationary phase.

Abstract: The presented invention relates to solid forms of Siponimod adipic acid salt and cocrystal.

Abstract: Described herein are polymorphic forms of a CB1 modulator, methods of making such forms, pharmaceutical compositions and medicaments comprising such forms, and methods of using such forms in the treatment of conditions, diseases, or disorders that would benefit from modulation of the CB1 receptor.

Abstract: The present invention relates to a process for the preparation of brivaracetam, a compound of formula I and salts thereof. The present invention also relates to a compound of formula II and a compound of formula IIA, process for its preparation and conversion thereof to brivaracetam, the compound of formula I.

Abstract: The present disclosure describes a method to treat conditions, including bacterial infections. The compounds of the disclosure can also interact synergistically with antibiotics used concomitantly to kill drug-resistant bacteria.

Abstract: There is provided herein a compound of formula I or a pharmaceutically acceptable salt thereof, wherein R1 and the ring comprising Q1 to Q5 have meanings as provided in the description.

Abstract: The invention relates to novel crystalline solid forms of salts of the chemical compound N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N?-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide, and solvates thereof, including hydrates, that are useful for the treatment of cancer. Also disclosed are pharmaceutical compositions comprising the crystalline solid forms and processes for making the crystalline solid forms, as well as methods of using them for the treatment of cancer, particularly renal cell carcinoma (RCC) and medullary thyroid cancer (MTC).

Abstract: High ATP production by the mitochondrial ATP-synthase is a new therapeutic target for anti-cancer therapy, especially for preventing tumor progression. A mitochondrial-related gene signature for metastasis is described, which features the gamma-subunit of the mitochondrial ATP-synthase (ATP5F1C). Knock-down of ATP5F1C expression significantly reduces ATP-production, 3D anchorage-independent growth and cell migration. Administration of the Bedaquiline, or a Bedaquiline derivative with a fatty acid moiety, down-regulates ATP5F1C expression in vitro and prevents spontaneous metastasis in vivo. Mitochondrial ATP5F1C is a promising new biomarker and molecular target for future drug development, for the prevention of metastatic disease progression.

Abstract: The present disclosure relates to the synthesis of prostate specific membrane antigen (PSMA) ligands that are useful in the treatment of diseases like cancer. In particular, the disclosure relates to a method for synthesizing PSMA ligands having a glutamate-urea-lysine (GUL) moiety and a chelating agent that can comprise a radiometal.

Abstract: Redox active polycyclic compounds and related electrode material, electrode chemical cell battery, methods and systems are described. In particular, tricyclic compounds having a redox potential of 0.20 V to 2.0 V with reference to Zn/Zn2+ electrode potential under standard conditions are described. More particularly, redox active monomers, dimers, and polymers in which each monomeric unit contains a tricyclic heterocyclic structure are provided as electrode material of a cathode for an electrochemical cell further containing a zinc anode and an aqueous electrolyte.

Abstract: Disclosed herein is a method for making a quaternary ammonium salt according to the formula Also disclosed is a method for making the ammonium salts from an oleofuran compound. The compounds are useful as antibacterial and/or antiviral compounds and methods for administering the compounds also are disclosed.

Abstract: The present invention relates to a novel method for preparing carbonylaminofurans of the general formula (I).

Abstract: [Problem] To provide a guanidine derivative (in particular, an amino acid compound having a 4-guanidino group) which has a low production cost and is less likely to cause the problem of waste liquor, a method for producing the same and an intermediate to be used in the production of the same. [Solution] A compound represented by formula (I), a tautomer thereof, an enantiomer thereof, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof; a method for producing a compound represented by formula (I), a tautomer thereof, an enantiomer thereof, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof, said method comprising a mixing step for mixing a compound represented by formula (II) with a compound represented by formula (III); and a compound represented by formula (IV) or formula (V).

Abstract: A method of manufacturing R-MDMA by forming a Grignard reagent from 5-bromobenzodioxole, treating the Grignard reagent with S-propylene oxide to form chirally pure alcohol 1, activating the alcohol as mesylate 2, converting to chirally pure azide 3, reducing the azide to amine 4, protecting the amine with di-tert-butyl dicarbonate, reducing the protected amine 5 to yield R-MDMA free base 6, and treating with an acid to form a salt 7 in >99% e.e. A method of manufacturing S-MDMA by forming a Grignard reagent from 5-bromobenzodioxole, treating the Grignard reagent with R-propylene oxide to form chirally pure alcohol 8, activating the alcohol as mesylate 9, converting to chirally pure azide 10, reducing the azide to amine 11, protecting the amine with di-tert-butyl dicarbonate, reducing the protected amine 12 to yield S-MDMA free base 13, and treating with an acid to form a salt 14 in >99% e.e.

Abstract: The present disclosure encompasses Lemborexant: succinic acid, a solid state form thereof, processes for preparation thereof, and pharmaceutical compositions thereof.