Abstract: A capsule endoscope, an endoscope system, and an image correction method are provided. The capsule endoscope includes an image sensor and a posture sensor. The image sensor is coupled to a processor and obtains a sensed image. The posture sensor is coupled to the processor and obtains three-axis data. The processor calculates a screen rotation angle according to the three-axis data and corrects the sensed image according to the screen rotation angle. A first axis and a second axis of the corrected sensed image rotate toward an actual vertical axis and an actual horizontal axis.

Abstract: An illumination optical system that transmits illumination light from a light source via a light guide to a distal end portion of an insertion part to irradiate an observation site from the distal end portion with the illumination light is provided. The illumination optical system includes a first lens located on a distal end side of the light guide and a second lens disposed on a distal end side of the first lens while holding a constant distance interval. An outer diameter of the second lens is larger than an outer diameter of the first lens and is 2.1 mm or more and 3.0 mm or less.

Abstract: A system and method reprocesses an internal channel of a medical device. The reprocessing system includes one or more valves, two or more fluid sources with each associated with a respective one of the valves, a pump that is able to dispense fluid from each of the two or more fluid sources, and a measuring device that measures a parameter of the fluid flow, where the parameter may be a fluid flow volume or a fluid flow time. The method includes using the pump and measuring device to dispense two or more fluids in sequence such that the pump and measuring device is shared among the two or more fluids.

Abstract: A clip for use in carpal tunnel surgery and similar surgeries has two separate clip sections, each with a proximal end that snaps together with the opposing proximal end of the other section, to make an assembled clip with a space between the sections except at proximal ends. At least one of the clip sections can be configured as a dilator, with a tapered distal end and without sharp edges. The two clip sections form endoscope and live channels to receive a viewing endoscope and a knife, inserted through the proximal end of the assembled clip device. Illumination is provided, either within the clip or from the scope of another inserted device, to enable viewing through the endoscope during a procedure. An embodiment of the clip device is formed with a rotation hub, such that the two clip sections can be swung apart or used together in a surgical procedure.

Abstract: A speculum operable to be disposed within an ear of a subject may include a housing. The housing may include a light conducting element. A transmitted optical illumination may be conducted by total internal reflection via the light conducting element. The housing may include a lumen. The housing may be configured to allow a reflected optical illumination to propagate through the lumen. The speculum may include one or more coupling portions which couple the transmitted optical illumination from a light source to the light conducting element. The one or more coupling portions may be shaped as a conic section.

Abstract: Particular embodiments disclosed herein provide a method for training a machine learning model to estimate the clinical significance of floaters in a patient's eye. One or more images, such as SLO images or en face retinal OCT images, are evaluated to identify shaded regions corresponding to floaters. The shaded regions are measured and the measurements processed using a machine learning model to obtain an estimated significance. The machine learning model is then updated according to a comparison of the estimated significance to a human-assigned clinical significance. The machine learning model may additionally or alternatively be updated by evaluating the estimated category with respect to visibility threshold data, such as one or more visibility threshold surfaces defined with respect to two or more variables.

Abstract: Particular embodiments disclosed herein enable psychophysical evaluation of vitreous floaters. One or more patient stimulus images are projected onto the patient's retina, the patient images including a stationary or mobile fixation target. While the patient stimulus images are displayed, images of the patient's retina are captured, such as using an SLO, and shadow images are derived from the images. The shadow images include representations of shadows cast by floaters. Observer stimulus images are generated from the shadow images and the patient stimulus images and projected onto the retinas of an observer, such as using a virtual reality display device.

Abstract: A method of detecting one or more change in an eye and a method diagnosing or providing an indication of an eye disease or eye condition or a neurodegenerative disease or condition, or a predisposition thereto are disclosed. The method of detection comprises comparing an image of the eye with at least one asynchronous image of the eye to thereby detect the one or more change in the eye wherein the change comprises a darkening or lightening in pigment of the Retinal Pigmented Epithelium (RPE) in the macula. The method of diagnosing or providing an indication of an eye disease or eye condition or a neurodegenerative disease or condition or a predisposition thereto comprises the same comparison and when the change is detected, providing a diagnosis of, indication of or to an eye disease or eye condition or a neurodegenerative disease or condition or a predisposition thereto.

Abstract: A device for a non-contact measurement of an IOP of a subjects eye including: a frame; a conduit connected to the frame and aligned along a conduit axis; at least one camera connected to the frame and configured to capture one or more image frames each comprising an image of a side view of a cornea of the subjects eye; a fluid pulse generator in fluid communication with the conduit, the fluid pulse generator configured to generate a fluid pulse and puff the fluid pulse through the conduit; and a controller comprising a processing unit, the processing unit configured to: receive the one or more image frames; determine one or more fluid pulse pressure values; and determine the IOP value of the subjects eye based on at least one of the one or more image frames and at least one of the one or more fluid pressure values.

Abstract: Systems and methods for aiding, supplementing, and/or increasing the monitoring capabilities of responsible persons over a supervised person are disclosed herein. In some implementations, the system includes one or more controlling persons, one or more supervising persons, a supervised person, and a cloud server. Each of the controlling persons and the supervising persons can have a personal electronic device. The supervised person can have a wearable electronic device. The electronic devices allow the controlling persons and the supervising persons to actively communicate with the cloud server to upload data related to the supervised person that is accessibly stored in the cloud server. In turn, the wearable device can include one or more sensors to measure and communicate various bioindicators to the cloud server. The system allows the controlling persons to monitor the health of, development of, and/or current control over the supervised person.

Abstract: A physiological data acquisition system includes an array electrode sensor (220) having plural electrodes and configured to acquire physiological data; a single electrode sensor having a single electrode and configured to acquire additional physiological data; and a hub that is configured to receive the physiological data from the array electrode sensor and the additional physiological data from the single electrode sensor only along body communication channels. At least one of the array electrode sensor and the single electrode sensor is configured to send an energy request signal to the hub, along the body communication channels. The hub, in response to the received energy request signal, emits radio frequency signals, which are used by the at least one of the array electrode sensor and the single electrode sensor to harvest energy.

Abstract: Magnetic Resonance Imaging (MRI) receiver coil devices, including a MRI receiver coil or MRI receiver coil arrays, for use in a MRI guided High Intensity Focused Ultrasound system, and methods for manufacturing the same. A MRI receive coil device includes a flexible substrate having a first surface and a second surface opposite the first surface, and a pattern of conductive material formed on one or both of the first and second surfaces, the pattern including at least one receive coil and at least one capacitor, wherein the flexible substrate comprises a dielectric plastic material. In certain aspects, at least one layer of hydrophobic material covers the at least one receive coil and the at least one capacitor.

Abstract: The present disclosure relates to a device for determining a biomarker concentration in a blood of a body part under consideration of the physiological constitution of the body part. The device comprises a light source for radiating first light waves to the body part, a detector unit for measuring the reflected first light waves reflected from the body part and a processing unit coupled to the detector unit for receiving the measured first light waves.

Abstract: Anatomical measurements of non-visible aspects of features of living organisms that include a visible contoured shape on the anatomical region of the living organism is disclosed. The system and method include an imager configured to take a series of images of an anatomical region of a living organism, such as a human patient in a clinic, doctor's office, or hospital. The system and method create a three-dimensional digital anatomical model of the exterior or visible part of the anatomical region that includes a target feature, such as a breast, nose, foot, or tumor. The target feature within the three-dimensional digital model is then isolated and manipulated to find measurements of non-visible aspects of the feature, such as mass, distances between visible points which pass through invisible tissues, e.g., depth and base width, surface distance between visible points, volume, area, surface area, circumference, and surface angle measurements of the feature.

Abstract: Embodiments related to methods of use of an image analysis system for identifying residual cancer cells after surgery are disclosed. In some embodiments, the image analysis system collects a surgical site image and indicates on a display one or more locations of the identified cancer cells. In some embodiments, the method for identifying residual cancer cells comprises determining and selecting a portion of the surgical site image responsive to an intensity parameter; modifying the selected portion of the surgical site image to determine one or more groups of residual cancer cells based on size; and identifying at least one of the one or more groups of residual cancer cells from the modified portion of the surgical site image using a local-based threshold.

Abstract: A system (SYS) for obtaining a three-dimensional (3D) scan of a body part or a complete body to enable inspection of at least a part of the body part or the complete body is described. The system has an image acquisition system (IAQ) configured for obtaining a plurality of images (IMGS) from the body part or the complete body from a first plurality of first viewing directions and configured for obtaining a plurality of depth maps (DIMGS) from the body part or the complete body from a second plurality of second viewing directions. The system has an image processor (IPROC) configured for determining a three-dimensional model of the body part.

Abstract: A photoacoustic imaging device is suitable for performing photoacoustic imaging on an object to be tested and includes a light emitting device and a light-transmissible ultrasonic transducer. The light emitting device emits a beam along an optical axis. The light-transmissible ultrasonic transducer is disposed on the light emitting device at the optical axis and includes a transparent substrate and a plurality of ultrasonic transducer units. The plurality of ultrasonic transducer units is disposed on the transparent substrate and allows the beam to pass therethrough and be incident to the object to be tested along the optical axis, for coaxially receiving an ultrasound transmitted from the object to be tested along the optical axis after the beam is incident into the object to be tested.

Abstract: A photoacoustic detector system combined with transparent ultrasonic sensors may include: a light source from which an optical oscillation device generates light for generating a photoacoustic phenomenon; a light transmission system which transmits the generated light to a probe side; a probe which accommodates an optical system and the transparent ultrasonic sensor therein; the optical system which adjusts the size, focus, path, and other parameters of the generated light; the transparent ultrasonic sensor which detects an ultrasonic wave generated in an observation area in response to light irradiated to the observation area according to a photoacoustic effect, and is made of a light-transmitting material to transmit the generated light; a data collection device which collects photoacoustic data including the ultrasonic wave detected by the transparent ultrasonic sensor; and a data detection device which analyzes the photoacoustic data and determines whether a specific material is detected in the observatio

Abstract: A malaria diagnosis and/or treatment apparatus can include an optical source and an acoustic detector in a single probe (sensor). The optical source can provide optical energy configured to produce transient vapor nanobubbles around malaria-specific nanoparticles, such as hemozoin in skin, blood and other tissues infected with malaria, but not in uninfected tissues. The acoustic detector can detect pressure pulses generated by the transient vapor nanobubbles. A malaria diagnosis and/or screening process can be based on using several metrics of the detector signal output, which include the time and amplitude parameters of such signal. This metrics characterize both active and residual forms of malaria disease and can be used in the clinical diagnostics of malaria and in mass screening of the malaria transmission.

Abstract: A method for screening a user temperature, the method comprising: detecting a user's face in a first image using a first camera operating within a first portion of the electromagnetic spectrum; aligning the detected user's face to a second image of the user's face detected using a second camera operating within a second portion of the electromagnetic spectrum which is different from the visible spectrum; determining the user's temperature based on the second image aligned to the first image; and determining if the user's temperature exceeds a predetermined threshold.

Abstract: In one aspect, a system for detecting blood in an oral cavity during toothbrushing is disclosed. A toothbrush includes a sensor configured to emit first light at a first wavelength and second light at a second wavelength, and receive reflected portions of the light, the reflected portions having a first intensity and a second intensity, respectively. For each of a plurality of different times of a brushing session, a processor calculates a ratio of the first intensity to the second intensity. The processor identifies peaks in the ratio over the different times and, based on the number of peaks in the ratio, determines whether hemoglobin is present in the oral cavity.

Abstract: An aircraft system includes an aircraft control having embedded biometric sensors. The biometric sensors record pilot physiological data at various phases of flight for analysis and pilot monitoring. The biometric data may be recorded and correlated to flight phases to establish a base-line profile for an individual pilot or an individual flight phase for later comparison and monitoring. Certain biometric data may be used as a secondary characteristic to confirm the identity of a pilot, or to verify that a pilot is currently engaging the aircraft control.

Abstract: The present application refers to a process and a system for collecting, storing, analyzing and visualizing electrocardiographic (ECG) data collected by portable ECG device (100) with embedded wireless communication technology, additionally containing a portable ECG device (100), a hermetically sealed box (200) of medicines containing a lock system comprising a lock (220), a first device (310) to be accessed by the patient, a second device (320) to be accessed by the medical professional, a platform for graphical display of ECG data, and a remote data storage and processing central. The hardware board of the portable ECG device contains wireless communication technology, global positioning system (GPS), start button (141), rechargeable battery charging port, and an equipment configuration and programming port. The battery (120) is Li-Ion type, containing LEDs indicating device operation, and waiting for connection. The battery status is displayed on the app display.

Abstract: A biometric information computing system that allows achieving a quantitative evaluation on a status of a user. A biometric information computing system that calculates blood information regarding blood of a user includes obtaining data, a database, calculating data, and evaluation of data. The system obtains evaluation data based on a pulse wave of the user. The database stores classification information generated using a plurality of training data. The training data is a pair of input data based on a preliminarily obtained training pulse wave and reference data including the blood information associated with the input data. The system calculates the blood information for the evaluation data by referring to the database. The system generates an evaluation result regarding a status of the user based on the blood information.

Abstract: Algorithms for continuous BP monitoring using the load cell ballistocardiogram and the finger/toe photoplethysmogram (PPG) signals. This disclosure includes two different approaches; (1) a conventional pulse transit time-based model and (2) a U-Net-based model to predict BP from ballistocardiogram and PPG signals. In pulse transit time-based models, the pulse transit time was acquired through signal processing and linear regression was performed on its inverse to estimate BP. In the U-Net-based model, the source signals (ballistocardiogram and PPG) were translated to BP waveforms from which the BP values were estimated after calibration.

Abstract: Systems, devices, and methods for measuring blood pressure without the use of a pump are provided. A pumpless blood pressure measuring system or device can be wearable for long periods of time comfortably. The pumpless blood pressure measuring system or device can include a body, at least one tension band connected to the body, at least one pressure sensor configured to be in direct physical contact with the user's body, and a tourniquet mechanism. The tourniquet mechanism can be tightened to lead to artery occlusion such that the at least one pressure plate can determine the blood pressure of the user/wearer.

Abstract: The invention relates to a method and a measuring device for continuously non-invasively determining at least one cardiovascular parameter, preferably the arterial blood pressure, at an extremity containing an artery, the measuring device comprising a receiving element that can be attached to the extremity and is suited to at least partly surround the extremity, and comprising a flexible bubble which is supported on the receiving element, acts on the extremity and is filled with a fluid. According to the invention, an actuator which is suited to vary the pressure in the flexible bubble is placed in or on the receiving element, and the flexible bubble includes a pressure sensor which is in contact with the fluid in the flexible bubble and which is suited to continuously measure the absolute pressure value. The measuring device further comprises a unit suited to measure the pulsations generated by the volume flow in the artery, and a control unit having two different modes of operation, i.e.

Abstract: This disclosure relates to methods for measuring one or more physiological signals while the user is engaged in a predetermined activity. Exemplary predetermined activities can include activities such as walking, climbing stairs, biking, and the like. The physiological measurements can include, but are not limited to, heart rate signals. The physiological measurements may be affected by the predetermined activity, so the system may be configured to employ one or more criteria prior to measuring physiological information to minimize the effects. The one or more criteria can include, but are not limited to, an inter-sampling waiting time, continuous motion criteria, predetermined activity criteria, a post-physiological measurement amount of time, and a confidence value. The continuous motion criteria can be based on the type of predetermined activity. For example, walking may have walking state criteria and a step count criteria.

Abstract: The present embodiment discloses an electronic method (100) for predicting physiological states of a subject. The embodiment involves predicting the physiological states instantly based on each peak of the pulses during heart beating. The physiological states may be clinical such as heart related, stress related problems, drowsiness, and so on. In some instances, the physiological states may be non-clinical such as behavioral-anger, anxiety, and so on.

Abstract: An earbud comprises at least two sensing devices, each located on a different part of the earbud. The earbud is shaped or dimensioned in such a way as to instill different extents of sensing devices displacements in response to user movements.

Abstract: Systems and methods for monitoring blood flow metrics using a patch of a flexible substrate configured to attach to an area of skin over a blood vessel. The patch includes a plurality of light sources arranged on the substrate to form a matrix and a row of photodetectors disposed on the substrate substantially in parallel with the rows of LEDs. The patch includes an optical signal interface configured to drive each light source and to input an intensity signal at one of the photodetectors. The intensity signals are used to determine AC and DC components corresponding to each optical path. AC to DC component ratios are calculated for each optical path and used to determine ratio-of-ratio values. At least a subset of the ratio-of-ratio values are used to determine a biological metric or a cross-sectional area of the blood vessel.

Abstract: Measuring device for non-invasively detecting the intracranial pressure pulsation of a patient, comprising a holding device which can be detachably attached to the outside of the patient's skull in a force-fitting and/or form-fitting manner, at least one bimorph bending sensor arranged in or on the holding device, an analog signal amplifier for amplifying the measurement data provided by the bimorph bending sensor, an A/D converter for converting the analog measurement data into digital data, and a computing unit for preprocessing the data and calculating vital parameters such as intracranial pressure based on the digital data. In addition, an associated method for non-invasive detection of intracranial pressure pulsation is described.

Abstract: Establishing an analyte database using analyte data that has been obtained using one or more non-invasive analyte sensors, and using the analyte database to analyze data obtained using a non-invasive analyte sensor. Once the analyte database is established, the analyte database can be updated with new analyte data, and the analyte database can be used to analyze the new analyte data to derive information from the new analyte data. For example, in the case of a human target, the new analyte data together with the analyte database can be used to predict an actual or possible abnormal medical pathology of the human target.

Abstract: The present invention provides a skin care diagnostic system characterized in that an LED light path is linked to a user terminal device having: a camera module for capturing an image of a skin surface; and a skin care service application generating control solution information of the LED light patch by analyzing the image captured by the camera module and an impedance measurement value received from the LED light patch. The LED light patch comprises: a BIA module for sensing the bioelectrical impedance of the skin surface; a BLE module for transmitting the impedance measurement value measured by the BIA module and receiving the control solution information of the LED light patch; a battery module comprising a thin-film battery; an LED module on which micro-LED devices are mounted in an array; and a control processor performing area-specific control, dimming control, wavelength control and user-selected care time control of the LED module in accordance with the received control solution information.

Abstract: Techniques are described for classifying tissue based on magnetic resonance image data, comprising. These may include acquiring magnetic resonance image data of a tissue region, detecting the tissue region contained within the magnetic resonance image data, acquiring information on an electrical property of the tissue region, and classifying the tissue region based upon the information on the electrical property of the tissue region.

Abstract: A computer-implemented method for assessing an image-generating procedure of magnetic resonance imaging, wherein in the image-generating procedure, an image recording procedure using at least one accelerating technique is combined with a reconstruction procedure comprising a reconstruction function trained using machine learning, wherein the method includes: establishing a spatially resolved image quality metric for a magnetic resonance image generated with the image-generating procedure; evaluating the image quality metric using at least one measure criterion with which at least one notification and/or adaptation measure is associated; and carrying out the at least one notification and/or adaptation measure for each fulfilled measure criterion.

Abstract: The invention relates to a medical microdevice (100) for insertion into a human body, wherein the microdevice allows for measuring at least one of a localization of the microdevice in a space and/or a physical parameter in the environment of the microdevice, wherein the microdevice comprises a casing (111) and within the casing a magneto mechanical rotator (110), wherein the magneto mechanical rotator comprises a magnetic object (113) providing a permanent magnetic moment and a rotary bearing (112) that is adapted to stabilize a rotational motion of the magnetic object, wherein the magneto mechanical rotator is adapted to transduce an external magnetic or electromagnetic excitation field into a mechanical rotation of the magnetic object relative to the rotary bearing such that a periodically changing magnetic response field is generated. The microdevice thus allows for an improved signal transmission and for a further miniaturization.

Abstract: A measuring device includes a hollow catheter and a guide wire which is insertable into the hollow catheter, where a catheter developing structure is arranged on the catheter, a distance of the catheter developing structure from a distal end of the catheter being less than a length of diseased tissue; a guide wire developing structure is arranged on a distal end of the guide wire, and a scale mark zone is arranged on the guide wire, a proximal end of the catheter can enter into the scale mark zone; the scale mark zone is configured to directly or indirectly measure a distance between the proximal end of the catheter and the end portion of the guide wire, and further measure the length of the diseased tissue.

Abstract: A portable smart device designed to be held by a user or worn by the user for determining a breathing quality of a user during a breath training session. The portable smart device including a sensor configured to detect a breathing parameter of the user and output a breathing parameter signal. The breathing parameter including at least one of heart rate, heart rate variability, breathing rate, breathing rate variability, vagal tone, breath holding capability, variations in breath holding capability, blood oxygen saturation level and blood oxygen saturation level variability. The portable smart device also including and a processor configured to analyze the breathing parameter signal of the user during the breath training session to determine breathing parameter values, set the determined breathing parameter values as a baseline for the user, and output a semi-personalized breath training routine to the user based on baseline.

Abstract: Monitoring apparatus for measuring the respiratory rate of a subject comprises an upper arm unit attached to a subject's upper arm in use and containing at least one movement sensor and a photoplethysmograph configured to monitor blood volume within the subject's upper arm while the upper arm unit is worn on the subject's upper arm. The output from the photoplethysmograph and movement sensor(s) are processed to calculate and output an estimate of the rate of respiration of the subject. Respiratory cycle induced variations in the photoplethysmograph signal and movement sensor signals can be independently determined and there is a greater confidence in the calculated respiratory rate when these independent calculations give consistent readings. If there is insufficient confidence, no rate of respiration is displayed.

Abstract: An embodiment provides techniques for distinguishing between breathing events based on sensor data obtained from one or more wearable sensors. In one example, sensor data is obtained that includes one or more of a sensor signal and descriptive metadata of the sensor signal. Processing is applied to distinguish between a cough and another breathing event based on the sensor data, and an indication of a cough is provided.

Abstract: Apparatus for posturographic evaluation and for the therapeutic indication during a rehabilitation program of the systems involved in maintaining posture and balance of the patient, including two femoral accelerometer sensors installed on the thighs of the patient, a dorsal accelerometer sensor installed on the back in proximity to the D7 vertebra of the patient, held firmly in position by the restraint systems, an IOT platform whose surface has at least 16 load cells and in which the IOT platform includes a processing unit with internal processing circuit acquiring the output data from the load cells, from the two femoral accelerometer sensors and from the dorsal accelerometer sensor and sending the data to a central computer connected to an input device and to at least an output device and finally a dedicated software for the acquisition, analysis and processing of the input data for the real-time and post-processing uses.

Abstract: The present invention discloses a method and system for conducting interactive rehabilitation session for a user with continuous monitoring. The session for user is generated in form of tasks, using current condition of the user and/or recommendations provided by a physiotherapist. The tasks may be performed by the patient in virtual environment, using, one or more virtual objects. Further, the tasks performed by the user is continuously monitored by implementing image processing techniques. The monitoring is performed to check if the user is performing the tasks as recommended by the physiotherapist. In case a deviation is detected, dynamic feedbacks may be provided to the user in real-time to correct actions of the user. Further, upon ending the sessions, the user may be scored or graded for the session based on performance of the tasks.

Abstract: This disclosure generally relates to systems and methods for detecting, monitoring, and responding to abnormalities in an infant's heartbeat. One or more sensing devices may collect infant heartbeat related data, which may be filtered and converted to a frequency signal. The frequency signal may be monitored for irregularity or stoppage, and a processing module may determine whether the irregularity or stoppage is caused by an actual stoppage or irregularity in infant heartbeat. If infant heartbeat is determined to have stopped, a corrective action may be performed.

Abstract: A device and method for detecting the level of a compound in tissue, the device including: an illumination source operable to emit light from an optical opening into the tissue; a detector array having a plurality of photosites, each operable to detect light of the illumination source travelling through the tissue; wherein different photosites of the detector array are located at different distances from the optical opening; and a processor adapted for determining compound levels in the tissue based on differences in detected illumination levels at distinct wavelengths at different distances from the optical opening.

Abstract: The present disclosure provides devices, systems, and methods capable of optimizing in vivo electrochemical measurement of a molecule of interest, for example glucose. Disclosed aspects may include an interference zapping layer, to which an electric potential may be applied to prevent or minimize various interfering molecules from reaching a working electrode. Aspects of the present disclosure may additionally or alternatively include a sensor including multiple working electrodes. The sensors having multiple working electrodes may measure background current during sensing in order to determine background current specific to each electrode, current due to electrochemical interferents, and current due to the molecule of interest. Sensors may also be capable of executing a measurement mode whereby a plurality of currents are measured over a range of interference zapping layer potentials and a range of working electrode potentials.

Abstract: Aspects of the present disclosure provide devices and methods capable of optimizing in vivo electrochemical measurement of a molecule of interest, for example glucose. Such aspects may include an engineered binding protein, for example an engineered glucose binding protein. The engineered binding protein may change conformation in response to binding or unbinding to a ligand and/or analyte, for example glucose. Such conformational changes may either expose or occlude a redox molecule attached to the binding protein. When exposed, the redox molecule may generate a redox signal dependent upon the binding protein's conformational state. The redox signal may be measurable, for example by cyclic voltammetry. The protein may be incorporated into a sensor that can be used as an implantable continuous glucose monitoring device.

Abstract: A physiological signal monitoring device includes a sensing member and a transmitter connected to the sensing member and including a circuit board that has electrical contacts, and a connecting port, which includes a socket communicated to the circuit board and a plurality of steel balls. The sensing member is removably inserted into the socket. The steel balls are electrically connected to the electrical contacts and the sensing member for enabling electric connection therebetween. Each of the steel balls is frictionally rotated by the sensing member during insertion of the sensing member into the socket and removal of the sensing member from the socket.

Abstract: Systems and methods are disclosed for providing ongoing monitoring and updating of blood volume status, where the system or method can include guidance in the form of recommendations for treatment actions or alerts about altered patient status.

Abstract: Provided is a biometric information computing system for improvement of evaluation accuracy. The biometric information computing system that outputs information relating to a feature of blood carbon dioxide of a user includes obtaining data, a database, and generating data. The system obtains evaluation data based on a pulse wave of the user. The database stores classification information generated using a plurality of training data, and the training data is a pair of input data based on a preliminarily obtained training pulse wave and reference data including the feature of blood carbon dioxide associated with the input data. The system further generates an evaluation result including the feature of blood carbon dioxide for the evaluation data.