Abstract: A biometric information computing system capable of generating a blood lactate level of a user with high accuracy. The biometric information computing system that generates a blood lactate level of a user includes obtaining evaluation data based on a pulse wave of the user, a database that stores classification information generated using a plurality of training data, and the training data is a pair of input data based on a preliminarily obtained training pulse wave and reference data including a blood lactate level associated with the input data, and generating an evaluation result including the blood lactate level for the evaluation data.

Abstract: In one embodiment, a method includes accessing a sequence of images of a portion of a person's skin illuminated by ambient light and determining, from at least one of the images, a plurality of microregions in the portion of the person's skin. The method further includes determining, based on a similarity between particular microregions of the plurality of microregions, one or more regions of interest of the person's skin; determining, for each of the regions of interest, a remote photoplethysmogram (rPPG) signal based on the sequence of images; and determining, based on one or more of the rPPG signals, an estimate of an oxygen saturation in the person's blood.

Abstract: Disclosed herein are medical systems, devices, and methods for performing vascular treatments and diagnoses. A vascular device include an optical fiber including a single fiber core disposed offset from a central axis of the optical fiber. The single fiber enables logic of the system to perform determine multiple conditions of the device and the patient. The conditions may include one or more of blood flow parameters, infusate delivery parameters, location of the device within the patient, pH of the blood, oxygen level of the blood, damage to the optical fiber, or core temperature of the patient. The elongate medical device may be a catheter, a stylet, a guidewire, or a probe.

Abstract: A method of analyzing a blood sample from an animal is disclosed. The method includes: (a) extracting a blood sample from a blood collection device, wherein the blood collection device comprises: (i) a microneedle array and (ii) a blood storage layer, and wherein the microneedle array transports the blood sample from the animal to the blood storage layer, and wherein the microneedle array comprises one or more microneedles; (b) conducting at least one test on the extracted blood sample; and (c) reporting results from the at least one test to a customer.

Abstract: Provided herein is a device including a housing having a proximal end, a distal end, and a sidewall therebetween defining an interior, a fluid conduit displaceably received within the housing interior and having a proximal end and a distal end, the fluid conduit having a first conduit portion at the proximal end of the fluid conduit, at least a portion of the first conduit portion coated with an antimicrobial coating and a second conduit portion at the distal end of the fluid conduit, wherein the fluid conduit is configured to be advanced from a first, proximal position in which the second conduit portion does not extend beyond a distal end of a catheter of the intravenous catheter assembly to a second, distal position in which the second conduit portion extends beyond a distal end of a catheter of the intravenous catheter assembly.

Abstract: An integrated catheter system includes a catheter adapter, a needle-free connector including a first port, a second port positioned opposite the first port, and a side port positioned between the first port and the second port, intermediate tubing extending between the inlet of the catheter adapter and the first port of the needle-free connector, extension tubing extending from the side port of the needle-free connector, first indicia provided on a first portion or a second portion of the needle-free connector, and second indicia provided on the first portion or the second portion of the needle-free connector. The first indicia including a first color and the second indicia including at least one of a maximum pressure rating marking, a flow rate capability marking, and a catheter length marking.

Abstract: The invention is related to a hand-operated actuator mechanism for driving a piercing element with increased safety. The actuator mechanism comprises a mounting element connected to a trigger element by a first breakable connection element. It also comprises a piercing element carrier connected to the trigger element by a second breakable connection element. The trigger element further comprises a pushing member that can be pushed with a human finger. The first breakable connection element is configured to be broken by means of a predetermined pushing finger force pushing said pushing member. The piercing element carrier being movable between an initial position wherein the first and the second breakable connection elements are unbroken, and a stop position wherein an abutment stops a movement of the piercing element carrier.

Abstract: Methods are provided of measuring and improving attention of a person with first and second eyes. These methods include: displaying one or more stimuli aimed at attracting attention of the person; obtaining, through an eye tracker, positions of the first and second eyes over time; calculating, from the obtained positions of the first and second eyes, a gaze direction evolution for each of the eyes and corresponding angular velocity evolution for each of the gaze directions; determining a motion synchrony evolution of the first and second eyes by comparing the calculated angular velocity evolution of the first eye with the calculated angular velocity evolution of the second eye; and measuring the attention of the person depending on the determined motion synchrony evolution. Computer programs, systems and computer systems that are suitable to perform such methods of measuring and improving attention are also provided.

Abstract: A diagnostic hub located in a toilet receives a wireless signal from a mobile device of a user and determines that the user is proximate to the toilet based on the wireless signal. An identification of the user is determined based on the wireless signal. A geolocation of the diagnostic hub is determined. Sensor data generated by biometric sensors and environmental sensors is received. The diagnostic intakes a mixture of water and urine from the toilet into an intake chamber of the diagnostic hub through an inlet line or one or more openings in a housing of the diagnostic hub. A lab-on-a-chip of the diagnostic hub executes a biochemical assay on a fluid volume of the mixture using a reagent. Substance levels present in the urine are determined based on the biochemical assay. Results based on the substance levels are determined, indicating a diagnosis of one or more diseases or medical conditions.

Abstract: Devices, systems, and methods herein relate to electromyography (EMG) that may be used in diagnostic and/or therapeutic applications, including but not limited to electrophysiological study of muscles in the body relating to neuromuscular function and/or disorders. Sensor assemblies and methods are described herein for non-invasively generating an EMG signal corresponding to muscle tissue where the sensor may be positioned directly on a surface of the muscle tissue including any associated membrane (e.g., mucosal, endothelial, synovial) overlying the muscle tissue. A sensor assembly may include one or more pairs of closely spaced, atraumatic electrodes in a bipolar or multipolar configuration. The first and second electrodes may be applied against a surface of muscle tissue (that may include a membrane overlying the muscle) and receive electrical activity signal data corresponding to an electrical potential difference of the portion of muscle between the electrodes.

Abstract: A signal analysis device includes a biological information acquisitor that acquires a waveform of a time section of an R wave included in a waveform for one cycle indicating a cardiac cycle of a heart of an analysis target as a target time waveform, and an analyzer that, upon approximating the target time waveform by an approximate time waveform that is a time waveform obtained by a difference or a weighted difference between a first cumulative distribution function and a second cumulative distribution function, acquires at least one of at least some parameters of parameters identifying a first unimodal distribution, at least some parameters of parameters identifying the first cumulative distribution function, at least some parameters of parameters identifying a second unimodal distribution, or at least some parameters of parameters identifying the second cumulative distribution function as a parameter indicating activity of a myocardium of the heart.

Abstract: A method for detecting and classifying a beat in an electrocardiogram (ECG) signal includes detecting a QRS waveform in an ECG signal using a waveform detection model, and detecting a class of a cardiac event capable of being derived from the QRS waveform; and detecting a unique R-peak in the QRS waveform using a regression model.

Abstract: A method includes, during arrhythmia occurrence, acquiring multiple sets of reference coronary sinus electrophysiological (CS-EP) signals with a first catheter in coronary sinus (CS) of a heart of a patient, while measuring multiple respective reference CS locations of the first catheter. One or more intra-cardiac electrophysiological (IC-EP) signals are acquired with a second catheter located in a cardiac chamber of the heart, while acquiring actual CS-EP signal with first catheter, and while measuring an actual CS location of first catheter. Using reference CS locations, reference CS-EP signal is identified whose reference CS location is nearest to actual CS location of the first catheter. A signal-stability measure between actual CS-EP signal and identified reference CS-EP signal is estimated.

Abstract: The present invention provides a system and method of monitoring brain injury rehabilitation and a rehabilitation method which utilizes a non-invasive monitoring device.

Abstract: Systems and methods are disclosed for conducting spinal cord stimulation or other neurostimulation and sensing evoked compound action potential (ECAP) signals. The sensed signals may be processed to isolate ECAP features from noise and/or interfering signals. The isolated ECAP features may be used to control neurostimulation therapy for the patient, such as to quantify or measure lead migration and adjust a neurostimulation therapy for the patient to account for an impact of any detected lead migration, or other purposes (e.g., to guide an implant procedure).

Abstract: A method for content delivery includes dividing a reference group of human subjects into multiple segments according to one or more segmentation criteria. Subjective responses of the human subjects to a reference set of data items are collected, and neurophysiological responses of the human subjects to the data items in the reference set are measured. The human subjects are classified into multiple brain types according to the measured neurophysiological responses. Based on the collected subjective responses, a mapping is defined between the segmentation criteria and the brain types and is applied in predicting a brain type of a human subject outside the reference group. A content offering is selected for presentation to the human subject responsively to the predicted brain type.

Abstract: A method for mapping functionally related brain regions of a subject. The method includes receiving a structural brain image and a dataset of resting-state functional MRI (rs-fMR1) three-dimensional (3D) image frames of a brain of the subject includes 3D image frames of the subject's brain over time. A functional connectivity map identifying groupings of functionally connected voxels is overlaid on the structural brain image. Spontaneous brain activations associated with each voxel in a grouping of functionally connected voxels are time-correlated with spontaneous brain activations in one or more other voxels in the grouping of functionally connected voxels. A reference location map for a pre-defined resting state network is generated, including reference information output. The reference location map includes brain reference locations that are informative of the one or more resting-state networks to assist a user in identifying the resting state network of the functional connectivity map.

Abstract: Use of non-contact patient monitoring systems to detect, diagnose, monitor and/or adjust therapy for diseases or conditions that have motion-based symptoms, symptoms such as limb tremors, spasms, etc. that can be correlated to diseases or conditions such as Essential tremor, Parkinson's disease, restless leg syndrome, or a diabetic episode. Information garnered by the non-contact monitoring system, information such as location, frequency, severity, and duration of the motion, can be collected and analyzed so that a diagnosis can be made and/or a treatment plan developed and/or adjusted by the patient's caretaker. The non-contact monitoring can provide real-time feedback regarding effectiveness of therapies or treatments, such as, e.g., neurological stimulation.

Abstract: Parkinson's disease is characterized by degeneration of highly metabolic dopaminergic neurons which produce clinical signs to include tremor, rigidity, and glabellar reflex. There are few objective, inexpensive, sensitive, and specific tests for early diagnosis of Parkinson's disease. In this invention, patients who manifest early objective signs of possible Parkinson's disease are pretreated with a supplement to increase central nervous system NAD+, and then subsequently administered a sodium L-lactate infusion after which the signs of early Parkinson's disease are recorded. Remission of the early signs of Parkinson's disease is diagnostic for Parkinson's disease. A clinical trial is suggested.

Abstract: A method for identifying mild cognitive impairment by at least one processor of an apparatus according to some embodiments of the present disclosure is disclosed. the method comprises performing a task of acquiring digital biomarker data for identifying mild cognitive impairment of a user of a user terminal; performing a preliminary task to allow the user to check the task before performing the task; and acquiring gaze information of the user in conjunction with performing the task and the preliminary task; wherein the gaze information is used when determining displayed information in the preliminary task, and used when identifying mild cognitive impairment of the user in the task.

Abstract: A method for analyzing and displaying functional lumen imaging probe (FLIP) measurement data includes receiving FLIP measurement data. A heatmap or topograph of the measurement data is generated and displayed to thereby create an image of a diameter along the lumen. The image is segmented to display only diameters of the lumen within a range of diameter values specified by a user.

Abstract: The invention provides a fetal position monitoring system, comprising an abdominal belt or a glove comprising a force and/or deformation sensor arrangement for obtaining resistance information of a plurality of local areas of the abdomen in response to an applied pressure. A data analysis processor interprets the resistance information to derive a fetal position and/or fetal size and optionally also fetal movement and an output is provided giving a representation of the fetal position and/or fetal size and optionally also fetal movement. This system provides a way of generating an output of the fetal position or size which requires minimum medical knowledge of the user, and it may be used at home.

Abstract: A non-invasive method for measuring a physical quantity representative of the elasticity of a material, including: determining the phase velocities of the fundamental mode of the various components of a shear wave generated at the surface of the material, along a measurement axis, the set of pairs, each formed by a frequency f, and the phase velocity Vi of the fundamental mode determined for the frequency fi, forming a dispersion curve of the fundamental mode in a measurement direction parallel to the measurement axis, wherein the index i is an order number of the frequency fi and of the phase velocity Vi, and transforming the dispersion curve into a profile of phase velocities as a function of depth, the phase velocity at a given depth being a physical quantity representative of the elasticity of a material at the depth.

Abstract: A method for automatically detecting a landmark in three-dimensional (3D) dental scan data includes projecting 3D scan data to generate a two-dimensional (2D) depth image, determining full arch data obtained by scanning all teeth of a patient and partial arch data obtained by scanning only a part of teeth of the patient by applying the 2D depth image to a convolutional neural network model, detecting a 2D landmark in the 2D depth image using a fully-connected convolutional neural network model and back-projecting the 2D landmark onto the 3D scan data to detect a 3D landmark of the 3D scan data.

Abstract: A method includes receiving physiological data associated with a sleep session of a user. The method also includes identifying a triggering event based at least in part on the physiological data. The method also includes generating image data in response to identifying the triggering event, the image data being reproducible as one or more images of at least a portion of the user during the sleep session. The method also includes causing at least a portion of the image data to be communicated to the user subsequent to the sleep session.

Abstract: Measurement control part measures contact pressures and a contact speed of a hand of a contacting person. The contact pressures change over time at respective positions, as measured values respectively based on two sensors when the hand of the contacting person touches sequentially to the two sensors being capable of detecting contact pressure. A determination control part compares measured values with reference ranges respectively, the reference range being a predetermined for a contacted person feeling comfortable when touched by the contacting person, and determines whether or not the measured value is within the reference range for each of measured values. An evaluation control part evaluates that the touching of the contacting person is a comfortable touching when all the measured values are within corresponding reference ranges respectively, and evaluates that the touching of the contacting person is an uncomfortable touching when one measured value is outside the corresponding reference range.

Abstract: Disclosed is a wearable robotic device that can replace the standard clinical tests used in the follow-up of MS (Multiple Sclerosis) disease, can make measurements with high precision, and enables monitoring the phase of MS disease and the process of response to the treatment at frequent intervals. The device allows the patients to perform dynamic activities and contributes to the good course of the disease as it is able to stimulate when the patients deliver different performance than the healthy people normals.

Abstract: A wearable medical device includes: a spatial sensor configured to determine distance to objects in an environment in front of the spatial sensor; an acoustic signal generator operable to generate an acoustic signal; a processor; and a memory configured to store instructions which, when executed the processor, cause the wearable medical device to: detect, using the spatial sensor, objects in the environment, calculate the distance to objects detected in the environment, and when the distance to an object is less than a predetermined value, control the acoustic signal generator to generate a first alert.

Abstract: A measurement system includes a measurement unit configured to perform measurement a plurality of times on the basis of a first clock signal having a first clock period to obtain a plurality of measurement results, a time stamp provision unit configured to provide a time stamp indicating a measurement time to each measurement result obtained in the second period among the plurality of measurement results obtained using the measurement unit the basis of a second clock signal having a second clock period longer than the first clock period and having better period accuracy than the first clock signal, and a measurement time correction unit configured to correct a measurement time of a measurement result in accordance with a period specified using two time stamps and the number of measurement results obtained during the period.

Abstract: A catheter assembly or other elongate tubular device for use in establishing vascular or other access within the body of a patient is disclosed. The catheter assembly is equipped with one or more sensors that enable monitoring of one or more physiological aspects of the patient or physical aspect of the catheter assembly itself when the catheter assembly is disposed within the patient. Such aspects include central venous pressure, body temperature, ECG heart signals, oxygen levels, ultrasound data, glucose, etc. The catheter assembly includes the ability to wirelessly transmit or otherwise forward data relating to the detected physiological parameters to another location, such as a patient electronic medical record, smartphone or other mobile device, nurse station, etc. Catheter assemblies configured to detect the frequency of catheter flushing, flushing quality, etc., are also disclosed.

Abstract: Devices and methods for monitoring internal physiological parameters of animals. Such a device and method makes use of a housing configured for implantation in an animal, and at least first and second arms pivotally coupled to the housing to have a collapsed configuration and a deployed configuration, wherein the first and second arms are alongside the housing and approximately parallel to the longitudinal axis in the collapsed configuration, expanded outward away from the housing and not parallel to the longitudinal axis in the deployed configuration, and biased toward the deployed configuration. Sensors are associated with the housing for collecting physiological parameters of the animal. The device is further equipped with a wireless transmitter for wirelessly transmitting outputs of the sensors to a receiver while the housing is implanted internally within the animal and the receiver is located externally of the animal.

Abstract: The terminal may include a touch panel including first electrodes arranged in a first direction and second electrodes arranged in the second direction intersecting the first direction, a display panel attached to the touch panel and to display an image, and a processor to control the touch panel and the display panel. In a measuring mode, the processor is configured to: apply a driving signal to the touch panel, the touch panel being configured to form an electric field and/or magnetic field when the driving signal is applied, and determine body composition of a user based on a sensing signal output from the touch panel in accordance with eddy current, the eddy current being induced to a body of the user by the electric field and/or magnetic field formed around the touch panel.

Abstract: An alert system usable to protect an individual from infectious disease is disclosed. The alert system can make use of one or more body-worn sensors to identify different entities within an environment, as well as their positional relationship (e.g., distance) to a reference location (e.g., the user and/or the alert system). The alert system can present alerts, such as through an augmented reality (AR) display, to identify potential risks and provide information to help minimize risk of infection. The AR display can identify risks with helpful and easy-to-interpret graphics or other overlays. Potential risks can include proximity to other individuals in an environment, contact with high-touch surfaces (e.g., fomites), insufficient cleaning (e.g., insufficient handwashing techniques), and others. The alert system can monitor the environment in real-time to assist the user in preventing transmission of pathogens to or from the user.

Abstract: Embodiments are directed to a non-transitory computer-readable storage medium comprising instructions that when executed cause processor circuitry to generate a longitudinal dataset of a set of features from tracked physical measurements of a user received from sensor circuitry, apply at least one machine learning model to the longitudinal dataset of the set of features to identify a pattern within the set of features indicative of a probability of the user being in a state of menopause, predict a current state of menopause for the user based on the identified pattern, and communicate a data message indicative of the current state of menopause for the user. In some embodiments, the set of features are compressed to pseudo-features and input to a first ML model using a second ML model.

Abstract: Apparatus for aligning a scan field of a medical scanner with a patient support, the apparatus comprising: at least one fiducial marker mounted to the patient support; a camera mounted to the medical scanner for imaging the at least one fiducial marker mounted to the patient support; a transport mechanism for moving the medical scanner relative to the patient support; and a computing system for instructing the transport mechanism to move the medical scanner to align the scan field of the medical scanner with the patient support.

Abstract: An x-ray system includes an x-ray source which, when in operation, generates x-rays at a plurality of x-ray focal spots, with a collimator allocated in each case to each x-ray focal spot. The collimator selects x-rays generated in the respective x-ray focal spot and directed onto a common detector, collimators being in a fixed position in relation to the respective allocated x-ray focal spots. The x-ray source is embodied as an x-ray tube with at least one anode including the x-ray focal spots and with a plurality of cathodes. Or the x-ray source includes a plurality of x-ray tubes, the anodes whereof include the x-ray focal spots. The collimators are arranged in the respective x-ray tube, and the collimators are arranged on the respective anode. A method is further for operating such an x-ray system.

Abstract: A photon counting detector (PCD) apparatus includes a PCD array including a plurality of micro-pixels positioned in at least one of a channel direction and a row direction; and processing circuitry configured to: receive signals from each of the plurality of micro-pixels; configure the PCD array to include (a) a first micro-pixel area including a first group of plural micro-pixels of the plurality of micro-pixels and (b) a second micro-pixel area including a second group of plural micro-pixels of the plurality of micro-pixels, such that a portion of the first and second groups of plural micro-pixels overlap between the first and second groups; bin the signals from the first group of plural micro-pixels into a first virtual bin value; and bin the signals from the second group of plural micro-pixels into a second virtual bin value.

Abstract: A non-transitory computer-readable medium storing a computer program capable of providing an easy-to-interpret image. A computer acquires, according to a computer program, a signal data set by a first inspection wave emitted in a direction inclined at a first angle with respect to a longitudinal axis direction of an imaging core used in a catheter. Then, the computer constructs an image obtained by using a direction inclined at a second angle different from the first angle with respect to the longitudinal axis direction of the imaging core as an observation target, based on the acquired signal data set.

Abstract: For a biopsy guided by contrast-enhanced x-ray imaging, a breast imaging system may image a patient's breast subsequent to injection of contrast agent to locate a site for biopsy and/or position a biopsy device relative to the site. Once a tissue specimen is removed from the site for diagnostic evaluation, a confirmation that the specimen was removed from an intended area of interest for biopsy is performed using the systems and methods described herein. For example, the breast imaging system and/or a separate specimen imaging system may capture high and low energy images of the specimen, subtract the low energy image from the high energy image to generate a subtracted image of the specimen, and determine, based on the subtracted image, that the contrast agent is present within the specimen to confirm the site from which the specimen was removed is the intended site for biopsy.

Abstract: In some embodiments, an X-ray system comprises a work-station and a mammography apparatus. The mammography apparatus can comprise: a breast positioning area; an absorption contrast imaging apparatus; and a diffractometer for analyzing structure of tissue within a breast. The absorption contrast imaging apparatus and the diffractometer can be configured to move in order to interchangeably align with the breast positioning area. The work-station can be configured to control the mammography apparatus, and to process data received from the mammography apparatus.

Abstract: A system and method for creating multi-phase kidney computed tomography (CT) images of a patient are provided. The method includes acquiring or accessing CT data that includes a first dataset acquired from the patient during a first phase when a dose of a contrast agent is being excreted from a kidney of the patient and does not include a second dataset acquired from the patient during a second phase after the dose of the contrast agent is delivered but before the dose of a contrast agent is being excreted from a kidney.

Abstract: A processor acquires two radiation images based on radiation that is transmitted through a subject including a plurality of compositions and has different energy distributions from each other, derives body thicknesses of the subject as a first body thickness and a second body thickness, respectively, for each pixel for each of the two radiation images by using an attenuation coefficient according to an order in which the radiation is transmitted through the plurality of compositions, and derives a composition ratio of the subject for each pixel of the radiation image based on the first body thickness and the second body thickness.

Abstract: A processor derives, based on at least one radiation image based on radiation that is transmitted through a subject including a plurality of compositions, a thickness of at least one composition of the plurality of compositions for each pixel of the radiation image, and derives a composition image for the at least one composition by using an attenuation coefficient based only on the thickness of the at least one composition.

Abstract: Embodiments provide a modular phantom that enables quantitative assessment of imaging performance (e.g., spatial resolution, image uniformity, image noise, contrast to noise ratio, cone-beam artifact) and dosimetry in cone-beam computed tomography (CT). The modular phantom includes one or more modules for various imaging performance tests that may be rearranged in the phantom to accommodate the design of various cone-beam CT imaging systems. The modular phantom includes one or more of a cone-beam module, an angled edge module, or a line spread module. The phantom may be inserted into a larger sleeve and be used to assess imaging performance and dosimetry in whole body CT imaging systems.

Abstract: A method of determining performance characteristics of a breast compression paddle utilized in a breast imaging system includes receiving a force application signal, wherein the force application signal is associated with an application of a compressive force by the breast imaging system with the breast compression paddle to a breast of a patient. The method applies the force application signal to an algorithm to obtain a reduction value. The reduction value is subtracted from a known paddle performance value for the breast compression paddle to obtain an updated paddle performance value for the breast compression paddle.

Abstract: A chest piece for a wireless stethoscope system can be configured to receive, from the accelerometer, motion data; determine, based on the motion data, that the chest piece has experienced no moment for a time threshold; and command the chest piece to enter a sleep mode that consumes less power in response to determining that no moment has occurred for the time threshold.

Abstract: There is provided a non-invasive method of generating image data of intra-cranial tissue using ultrasound energy that is transmitted across a head of a subject through the skull of the subject.

Abstract: An ultrasound probe includes a probe body including a side surface and a bottom surface, a display unit on the side surface, first and second imaging units arranged on the bottom surface, separated from each other in a first direction, and each configured to acquire a cross-sectional image of a human body, and a controller configured to determine a position of a blood vessel using the cross-sectional image acquired by each of the first and second imaging units, determine an orientation of the blood vessel based on the determined position of the blood vessel, and control the display unit to display an indicator indicating the orientation of the blood vessel.

Abstract: The invention relates to a medical system comprising a tool including: a body; a location measurement device adapted to emit an ultrasound location signal and receive a reflected location signal; a location processing device adapted to compare each of the echoes of the reflected location signal to a pre-determined location threshold, emit an information signal if no target location echo corresponding to the interface between first and second anatomical structures has been identified within an analysis time window, the target location echo having an amplitude that exceeds the location threshold.

Abstract: An ultrasonic tonometer for measuring intraocular pressure of a subject eye by using an ultrasonic wave. The ultrasonic tonometer includes an irradiation unit configured to irradiate the subject eye with a focused ultrasonic wave, and a Z-alignment detection unit configured to detect an alignment state in a working distance direction with respect to the subject eye. An appropriate Z-alignment position is set to a position that is farther from the irradiation unit than is a geometric focal position of the irradiation unit. The appropriate Z-alignment position is detected by the Z-alignment detection unit.