Abstract: A surgical severing and stapling instrument, suitable for laparoscopic and endoscopic clinical procedures, clamps tissue within an end effector of an elongate channel pivotally opposed by an anvil. An E-beam firing bar moves distally through the clamped end effector to sever tissue and to drive staples on each side of the cut. The E-beam firing bar affirmatively spaces the anvil from the elongate channel to assure properly formed closed staples, especially when an amount of tissue is clamped that is inadequate to space the end effector. In particular, an upper pin of the firing bar longitudinally moves through an anvil slot and a channel slot is captured between a lower cap and a middle pin of the firing bar to assure a minimum spacing. Forming the E-beam from a thickened distal portion and a thinned proximal strip enhances manufacturability and facilitates use in such articulating surgical instruments.

Abstract: A deployment device for a tissue repair system includes a front delivery assembly that is detachable from a base assembly of the deployment device. The front delivery assembly includes at least one prosthesis and at least one driven assembly that actuates the at least one prosthesis. The base assembly includes a driving assembly that may engage the at least one driven assembly of the at least one prosthesis. The front delivery assembly can be rotated so that the position of a prosthesis in the front delivery assembly is moved in and out of alignment with the driving assembly. A kit of parts may be provided that includes a base assembly as well as two or more detachable front delivery assemblies.

Abstract: An electrosurgical connection unit for a surgical robot arm to connect an electrosurgical instrument attached to the arm to an electrosurgical generator. The electrosurgical connection unit includes an input port connectable to the electrosurgical generator, the input port configured to receive a driving electrosurgical signal and output one or more activation signals; an output port connectable to the electrosurgical instrument, the output port configured to output the driving electrosurgical signal received on the input port; one or more activation switch units, wherein activation of an activation switch unit causes an activation signal to be output from the input port indicating a driving electrosurgical signal with a desired waveform is to be activated; and a control unit configured to selectively activate one of the one or more activation switch units in response to a control signal.

Abstract: A system and method for data filtering of passageway sensor data include traversing a plurality of passageways with a flexible elongate device and recording, during the traversing, positional data using one or more sensors coupled to the flexible elongate device. The positional data includes a first plurality of positional data points recorded during a first insertion of the flexible elongate device into a first passageway and a second plurality of positional data points recorded during a first retraction of the flexible elongate device within the first passageway. The system and method further include labeling the first plurality of positional data points and the second plurality of positional data points as first common passageway positional data points and registering the positional data with a model of the plurality of passageways, wherein the registering includes matching the first common passageway positional data points with corresponding first common passageway model data points.

Abstract: Various torque-limiting surgical driver devices, systems, and methods are disclosed. The surgical driver can include a body, a motor that is configured to rotate a drill bit engaged with the surgical driver, and a processor configured to control operation of the surgical driver. The surgical driver can have torque-limiting functionality, such as by monitoring the amount of torque applied to a drill bit and reducing or stopping rotation of the drill bit when certain torque-limiting criteria are met.

Abstract: Composite markers employ a gel carrier to carry at least one radiopaque element (e.g., wire or band or clip) and one or more other contrast materials, each detectable by a detection modality different than one another. Methods for forming these composite markers and methods of marking a target site in a mammalian subject employing these composite markers are also discussed herein.

Abstract: A method for generating and updating a three-dimensional representation of a surgical site based on imaging data from an imaging system is disclosed. The method comprises the steps of generating a first image of the surgical site based on structured electromagnetic radiation emitted from the imaging system, receiving a second image of the surgical site, aligning the first image and the second image, generating a three-dimensional representation of the surgical site based on the first image and the second image as aligned, displaying the three-dimensional representation on a display screen, receiving a user selection to manipulate the three-dimensional representation, and updating the three-dimensional representation as displayed on the display screen from a first state to a second state according to the received user selection.

Abstract: Systems, devices, and methods for endoscopic mapping of a target and tracking of endoscope locations inside a subject's body during a procedure are disclosed. An exemplary system comprises an imaging system configured to capture an endoscopic image of the target that includes a footprint of an aiming beam directed at the target, and a video processor configured to identifying one or more landmarks from the captured endoscopic image and determine their respective locations relative to the aiming beam footprint, and generate a target map by integrating a plurality of endoscopic images based on landmarks identified from one or more of the plurality of endoscopic images. The target map can be used to track endoscope location during an endoscopic procedure.

Abstract: An endoscope system includes a light source that irradiates a predetermined first and second narrowband light; an imaging sensor that captures an image of return light of the first narrowband light and the second narrowband light from the subject, and generates an image signal of the image; and a processor being configured to identify a first color of a first portion and a second color of a second portion based on a difference of an optical density with respect to hemoglobin in the image signal in every frame of the image, the first portion corresponding to a bleeding area, and the second portion corresponding to an area other than the bleeding area within the subject, and correct the first color and the second color based on the identified first and second color while maintaining a color difference between the identified first and second color in a predetermined range.

Abstract: A computer implemented method comprises receiving a model of a tissue region, steering a distal end of a catheter within a body to a first area of a tissue region, and obtaining a first image from the distal end of the catheter of the first area of the tissue region. The method further comprises mapping the first image of the first area of the tissue region to the model of the tissue region and displaying the first image of the first area of the tissue region on the model of the tissue region.

Abstract: A distal tip of an endoscopic device and a cylindrical cap is disclosed. The distal tip comprises a pattern of alternating grooves and lands on its outer surface. The cylindrical cap is configured to fit tightly over the lands, thereby changing the grooves into closed channels through which liquid or gas can flow.

Abstract: An endoscope is provided in which an attachment/detachment operation of the proximal end of a wire can be easily performed to/from an erecting operation mechanism and the wire can be prevented from meandering in a wire channel. An endoscope has an operation section 22 provided with an erecting operation lever, and a movable member 96 that moves in association with an operation of the erecting operation lever. The movable member 96 is arranged to be exposed to outside of the operation section 22. A wire 60 has a distal end side coupled to an erecting base, and a proximal end side coupled to an attachment member 98 that is attachable to and detachable from the movable member 96 by a one-touch operation. The wire 60 is configured of a wire body 60A and a gap filling member 60B.

Abstract: An endoscope accessory, such as a coupler device, is provided that includes a main body with a visualization section for allowing viewing of tissue by the endoscope and a proximal end configured for attachment to a distal end portion of the endoscope. The device includes a passage within the main body having an exit portal and a proximal end aligned with the working channel of the endoscope. An instrument passing through the passage is capable of angular adjustment relative to the main body of the coupler device by actuation of the endoscope.

Abstract: A medical instrument system includes an imaging probe and an elongated medical instrument. The imaging probe includes a first sealing feature comprising a first tapered profile formed on an external surface of the distal tip. The elongated medical instrument has a working channel extending to an opening in the distal portion. The distal portion includes a second sealing feature comprising a second tapered profile formed on an internal surface of the channel. A distal end surface of the distal tip extends through the opening and distally of a distal end surface of the elongated medical instrument when the first sealing feature is engaged with the second sealing feature. The first tapered profile and the second tapered profile form a seal that prevents fluid from passing through the opening when the imaging probe is within the working channel of the elongated medical instrument and the first and second sealing features contact.

Abstract: A surgical apparatus includes a housing, a test port retainer, a pressure test chamber, and an image capture assembly. The housing includes a pressure test port. The test port retainer includes a test port retainer housing, a probe seal, and a liquid exclusion barrier. In one aspect, the test port retainer also includes a hydrophobic membrane mounted within the test port retainer housing. The pressure test chamber includes a manifold and a central tube. The first end of the central tube is affixed to the image capture assembly to form a pressure seal, and the second end of the central tube is coupled to the test port retainer so that the pressure test port communicates with the interior volume of the central tube through the test port retainer.

Abstract: A system includes an endoscope connector and an endoscope adapter. The endoscope connector includes a first portion. The first portion includes a first magnetic coupling element and a first planar portion that is perpendicular to an axial direction of the endoscope connector. The endoscope adapter includes a second planar portion. The second planar portion includes a second magnetic coupling element and a substantially planar surface that is perpendicular to an axial direction of the endoscope adapter. The endoscope connector is non-mechanically attachable to the endoscope adapter using the first magnetic coupling element and the second magnetic coupling element. The first planar portion is alignable with the second planar portion such that: electroconductive contacts of the endoscope connector are axially aligned with electroconductive pins of the endoscope adapter and a port of the endoscope connector is axially aligned with a corresponding insertion port of the endoscope adapter.

Abstract: Disclosed embodiments include apparatuses, systems, and methods for providing an atraumatic sheath tip. Various disclosed embodiments seek to help reduce or avoid unnecessary tissue damage upon a sheath being extended to convey an elongated instrument for sampling or treatment. In an illustrative embodiment, an apparatus includes a deformable sheath tip configured to be positioned at a distal end of a sheath. The sheath defines therein a lumen configured to convey an elongated instrument. The sheath tip has a base end disposable at the distal end of the sheath and a contact end. The sheath tip has a first column strength along an axis of the sheath tip that is less than a second column strength of the sheath and a first degree of deformability that is greater than a second degree of deformability of the sheath.

Abstract: A multi-focal, multi-camera endoscope having a tip section including a first optical assembly for generating a first image of a body cavity; a second optical assembly for generating a second image of a body cavity; at least one illuminator associated with each of the first optical assembly and second optical assembly; and a processing system configured to: zoom the first optical assembly and thereby generate a zoomed first image in place of the first image; and automatically cause a physical display to eliminate a display of the second image and to only display said zoomed first image. To eliminate the display of the second image, the processing system reduces a power supply to the second optical assembly, reduces an illumination intensity of an illuminator associated with the second optical assembly or causes the physical display to power off, darken, or blacken.

Abstract: A steerable device, such as a steerable catheter, may include a control handle and an insertion shaft extending outwardly therefrom. In use, the insertion shaft is navigated to an area of interest for examination and/or treatment thereof. The steerable device may include a steering system that controls the deflection angle of the distal end of the insertion shaft in two or more non-planar directions for navigating the insertion shaft to the area of interest. The steering system may also include a locking mechanism for arresting or partially arresting the movement of the distal end of the insertion shaft in a first direction independent of arresting or partially arresting the movement of the distal end in a second non-planar direction.

Abstract: A link for an articulation arm includes a vertebra, two outer bearing portions, two inner bearing portions and four control bore holes. The vertebra has a first base and a second base. The two outer bearing portions are formed on the first base and are located on a radial line of the first base. The two inner bearing portions are formed on the second base and are located on a radial line of the second base. The two of the four control bore holes enter the second base and exit a respective one of the outer bearing portions. The other two of the control bore holes enter the first base and exit a respective one of the inner bearing portions.

Abstract: Controlled motion capsules and associated systems and methods are described. Controlled motion capsules can decelerate, and stop, without damaging epithelial walls. If any components fail, a controlled motion capsule, without added energy, becomes its most compact shape, passing harmlessly through the GI tract. Controlled motion capsule may include a shape changing material, comprising a reversible soft copolymer, in a container in the capsule, with a nonionizing radiation emitter, and a controller to activate the nonionizing radiation to expand and contract the shape changing material, on detection of certain conditions or instructions. Expansion of the shape changing material, including contact with epithelial walls, decelerates and can stop the controlled motion capsule movement. Motion control allows scientists to study the microbiome, doctors to deliver intestinal drugs at precise locations, and to closely examine signs of precancerous growth.

Abstract: A video data cable for use with a video medical device comprising an image capture device includes a processor; data storage; logic to identify the video medical device; logic to determine which of the video medical device or the data cable have a most up-to-date set of image capture settings based on the identified video medical device; logic to transmit the most up-to-date set of image capture settings to the video medical device when it is determined that the data cable includes the most up-to-date set of image capture settings; and logic to receive the most up-to-date set of image capture settings to the video medical device when it is determined that the data cable includes the most up-to-date set of image capture settings.

Abstract: Irrigation and/or aspiration devices and methods may be configured to aspirate and irrigate alone, sequentially, or concurrently. The devices and methods may provide a base with a removable head, and adapted for partial or complete separation of the irrigation and aspiration functions. The devices and methods can be configured to aspirate and/or irrigate the nasal and sinus cavities. The devices and methods may be manually and/or automatically controlled. The devices and methods may include removable, and/or replaceable, and/or refillable, and easily cleanable reservoirs for aspirant and irrigant. The device head and/or aspirant reservoir may comprise a diagnostic device, i.e., test device and/or container after use of the devices and methods.

Abstract: Irrigation and/or aspiration devices and methods may be configured to aspirate and irrigate alone, sequentially, or concurrently. The devices and methods may provide a base with a removable head, and adapted for partial or complete separation of the irrigation and aspiration functions. The devices and methods can be configured to aspirate and/or irrigate the nasal and sinus cavities. The devices and methods may be manually and/or automatically controlled. The devices and methods may include removable, and/or replaceable, and/or refillable, and easily cleanable reservoirs for aspirant and irrigant. The device head and/or aspirant reservoir may comprise a diagnostic device, i.e., test device and/or container after use of the devices and methods.

Abstract: The present invention presents a method of fabrication for a physiological sensor with electronic, electrochemical, and chemical components. The fabrication method comprises steps for manufacturing an apparatus comprising at least one electrochemical sensor, a microcontroller, and a transceiver. The fabrication process includes the steps of substrate fabrication, circuit fabrication, pick and place, reflow soldering, electrode fabrication, membrane fabrication, sealing and curing, layer bonding, and dressing. The physiological sensor is operable to analyze biological fluids such as sweat.

Abstract: Various systems, devices, components, and methods are disclosed for measuring the concentration of an analyte, such as acetone, in a breath sample. The disclosed devices include a breath sample analysis device having a mouthpiece configured to facilitate engagement with a user's mouth to receive a breath sample. The disclosed devices also include a breath sample capture cartridge containing an interactant that extracts the analyte from a breath sample passed through the cartridge. Also disclosed are devices for routing the breath sample through the cartridge during exhalation, and for analyzing a reaction in the cartridge to measure a concentration of the analyte.

Abstract: An adapter assembly includes a base member, a housing, and a locking mechanism. The base member defines a longitudinal axis. The housing is rotatably secured to the base member and is rotatable in relation to the base member between a plurality of positions. The locking mechanism is supported on the housing and includes a locking member and a button. The locking member is moveable from a locked position in which a lock of the locking member is engaged with the base member to secure the housing in one of the plurality of positions to an unlocked position in which the housing is rotatable in relation to the base member. The button is positioned on the base member and is depressible to translate the locking member in a direction parallel to the longitudinal axis from the locked position to the unlocked position.

Abstract: A medical device including a removable frame and biomaterial cover, methods of assembling and using the same, and a delivery system including the same are described herein. The medical device includes a frame having proximal and distal ends, the frame including a proximal disc at the proximal end, a distal disc at the distal end, and a connecting segment having a proximal end and a distal end connecting the proximal and distal discs. Each of the proximal and distal discs includes a respective plurality of prongs and has a maximum cross-sectional dimension larger than the connecting segment. The medical device further includes at least one biomaterial cover including an outer section and an inner section defining a cavity therebetween, wherein at least one of the proximal and distal discs of the frame is positioned in the cavity.

Abstract: A retractor is designed to assist in cuff implantation procedure. It has a flat non-cutting retracting end at the distal. Its function is to isolate tissue of interest, to make access, and to retract tissue for cuff placement and removal while protecting critical tissue at the surgical site.

Abstract: A method and apparatus for securing separate loops of suture with a coaxial mechanical fastener. Separate loops of suture extend from opposite ends of the mechanical fastener. A wire snare facilitates pulling the suture through the fastener. A suturing instrument provides for the infusion of pressurized physiologic solutions into the left ventricle so that the proper replacement suture length can be demonstrated real time prior to crimping the fastener. The instrument incorporates a slotted release site so that the fastener and suture can be released from the device tip once the fastener is secured. A method of securing suture coming from cardiac valve leaflets and or other structures like papillary muscles permits a more atraumatic orientation of the fastener coaxial with the suture strands.

Abstract: Devices and methods for inserting an implant into skin or other tissue of a patient can include a hyaluronic thread coupled with an insertion device that can provide a supportive enclosure for the thread as it is injected into a patient's skin or other tissue. The device can include a moveable member and laterally extending portions, a closed distal portion, and an inner cavity so that the thread can be positioned within the inner cavity and extend along the moveable member. The laterally extending portions can move, relative to the thread, to expose the thread. In use, the moveable member is insertable into a patient and at least a portion of the moveable member is configured to move within a patient to expose the thread.

Abstract: A suturing kit includes a suture and a suture holder for holding the suture. The suture has a first end and a second, opposite, end. The suture holder includes an elongated wall defining a suture receiving passage that is elongated along a longitudinal axis and terminates at a suture exit opening. The suture receiving passage has a width at least twice the diameter of the suture and receives the suture such that the suture is folded over forming a half loop section spaced from the suture exit opening. A first second of the suture extends from the half loop section toward the first end and a second section of the suture extends from the half loop section towards the second end. The first section and the second section of the suture within the suture receiving passage are aligned parallel to the longitudinal axis.

Abstract: A surgical stapler comprising an end effector and a system configured to feed staples into the end effector is disclosed.

Abstract: A surgical instrument. The surgical instrument comprises a plurality of sensors, and a status module releasably connected to the surgical instrument. The status module comprises a plurality of contacts, a circuit, and a plurality of indicators. Each individual contact is in electrical communication with a different sensor. The circuit is in electrical communication with at least one of the contacts. At least one of the indicators is in electrical communication with the circuit.

Abstract: A surgical system includes first and second elements. The first element has a first bearing face and a first helical surface extending from the first bearing face. The second element comprises a second bearing face, complementary to the first bearing face, a second helical surface extending from the second bearing face and congruent with the first helical surface so that the helical surfaces form a helical connection centered on an axis, and a mechanism for controlling reversible connection between the elements, the mechanism being suitable for successively actuating according to a first movement, which includes an axial translation without involving any rotation and by which the mechanism meshes the helical surfaces until the bearing faces are axially juxtaposed, a second movement, which is a rotation about the axis and by which the mechanism locks the helical connection while the bearing faces are pressed axially against each other.

Abstract: A surgical hub for prioritizing data on a display using situational awareness of a medical instrument may be provided. A first surgical task that uses a medical instrument during a medical procedure may be determined based on a contextual data. A second surgical task that uses the medical instrument may be determined based on the first surgical task and the contextual data. A message may be sent that may instruct a display to prioritize a display data associated with the second surgical task.

Abstract: A tissue fastening device includes a body including a plurality of sidewalls defining a channel, an anvil having a proximal end and a distal end and pivotally coupled to the body and the anvil moves between an open position and a closed position, and a locking mechanism to lock the anvil in the closed position.

Abstract: A method of operating an articulatable surgical instrument. The method includes providing a rotary drive motion to a rotary drive member of a surgical end effector and converting the rotary drive motion to an upper axial motion and a lower axial motion at locations that are distal to the articulation joint. The method further includes applying the upper axial motion to an upper portion of a firing member and applying the lower axial motion to a lower portion of the firing member such that the upper axial motion and lower axial motion drives the firing member distally through the surgical end effector from a starting position to an ending position.

Abstract: A tissue thickness compensator comprising a first compensation layer, a second compensation layer, and a pocket situated between the compensation layers can be positioned in the end effector of a surgical instrument. A fastener cartridge positioned in the end effector can comprise a fastener moveable between an initial position and a fired position. When the fastener is moved from the initial position to the fired position, the fastener can move through the pocket and can compress a portion of the tissue thickness compensator. A support can be positioned between the first and second compensation layers. When the fastener compresses the tissue thickness compensator, at least one of the support, first compensation layer and second compensation layer can be deformed. The tissue thickness compensator can also comprise a tab and/or a limiting plate to control deformation of the compensation layers and/or the support.

Abstract: A cover member for a surgical staple cartridge. The cover member is configured to retain a wedge sled within the staple cartridge in a starting position when the cover member is attached to the body of the staple cartridge. The cover member includes a top portion that covers all of the fastener openings in the deck of the staple cartridge when the cover is attached to the cartridge.

Abstract: Various embodiments of a device for deep surgical corridor microvascular anastomosis are described herein. A device, comprising: an elongated body; a rod disposed at least partially within the channel of the elongated body; an actuator in association with the elongated body and the rod, wherein the actuator is operable to actuate the rod in a first axial direction; and a pair of coupling arms in association with the distal portion of the rod, wherein the actuator is operable to actuate the rod in a first axial direction such that the pivotable end of each coupling arm of the pair of coupling arms is consequently actuated in the first axial direction such that the pair of coupling arms are parallel with one another in a closed configuration.

Abstract: A tissue monitoring system includes a sensor, a sensor reader, and at least one computing device. The sensor is releasably coupled to a staple by a tether and is configured to measure a physiological parameter of tissue and convert the measurement into a signal. The sensor reader is configured to receive the signal from the sensor and the at least one computing device is configured to receive the signal from the sensor reader and process the signal into physiological data. The sensor is implanted in tissue by the staple.

Abstract: The volume of a hyperinflated lung compartment is reduced by sealing a distal end of the catheter in an airway feeding the lung compartment. Air passes out of the lung compartment through a passage in the catheter while the patient exhales. A one-way flow element associated with the catheter prevents air from re-entering the lung compartment as the patient inhales. Over time, the pressure of regions surrounding the lung compartment cause it to collapse as the volume of air diminishes. Residual volume reduction effectively results in functional lung volume expansion. Optionally, the lung compartment may be sealed in order to permanently prevent air from re-entering the lung compartment.

Abstract: Various systems, devices, components and methods are disclosed for controllably and selectively occluding, restricting, and/or diverting flow within a patient's vasculature. The flow restriction systems can include an implant having a flow restrictor and an implantable controller having an actuator for actuating the flow restrictor. The flow restriction systems can also include an external device for controlling operation of the implant via the implantable controller.

Abstract: A non-occlusive blood-restricting device is provided for treating a vascular malformation. The blood-restricting device includes a first section configured to assume a first shape when deployed from a microcatheter within a portion of the vascular malformation so as to at least partially cover an orifice of the vascular malformation, the portion of the vascular malformation including one or more anatomical features selected from the group consisting of: a neck of the vascular malformation and a wall of the vascular malformation. The first shape defines a sequence of loops having a gradually decreasing diameter and coaxial around a first central axis. The blood-restricting device also includes a second section configured to assume a second shape when deployed from the microcatheter. The second shape defines a single loop around a second central axis when the blood-restricting device is not restrained. Other embodiments are also described.

Abstract: An apparatus for treating an aneurysm in a blood vessel includes a wire to be advanced within a tube and an occlusion element disposed on the wire. The occlusion element includes a cover and an inner anchoring member. The occlusion element is configured to fit within the tube and slide out of an opening at distal end of the tube in response to movement of the wire. The cover is configured to expand to an expanded configuration when advanced into the aneurysm, wherein the cover comprises a diameter that is greater than the diameter of a neck portion of the aneurysm and is configured such that a first portion of the cover contacts an interior surface of the aneurysm and a second portion covers the neck portion of the aneurysm. The inner anchoring member extends from the cover portion and is configured to contact the interior surface of the aneurysm.

Abstract: A left atrial appendage (LAA) occluder, and a method of application are provided. The LAA occluder includes a plugging portion, a connecting portion, and a covering portion that are connected sequentially along an axial direction, where the plugging portion includes a first support mesh that can be transformed to have a reduced radial profile, and a first gathering member; a plurality of anchoring members for grasping LAA tissues are arranged on an outer peripheral surface of the first support mesh; the first gathering member is detachably connected to the connecting portion, such that the plugging portion can be provided individually at an LAA; the covering portion includes a second support mesh that can be transformed to have a reduced radial profile, and a second gathering member; and the second gathering member is provided at an end of the second support mesh away from the connecting portion.

Abstract: A cartridge may include a pair of side walls separated by a compartment, the compartment being configured to receive a surgical clip, and a base member supporting the pair of side walls. The pair of side walls may extend at an acute angle relative to a vertical axis of the base member to hold the surgical clip at the acute angle. The acute angle may be greater than 10° and/or about 20-30°. The cartridge may also include a pedestal extending between the pair of side walls and configured to support the surgical clip, where the pedestal is disposed at the acute angle. The cartridge may further include a retainer configured to retain the surgical clip in the compartment, the retainer including a pair of fingers configured to contact the surgical clip, where the pair of fingers are oriented at the acute angle.

Abstract: The instant disclosure is directed to devices and methods for deploying a biased occlusion clamp. In addition, the present disclosure includes devices and methods for deploying a biased occlusion clamp using robotics. Moreover, the present disclosure includes devices and methods for reducing the force necessary to open an occlusion clamp without permanently compromising the clamping force of the clamp itself.

Abstract: A system includes a clip having a pair of clip arms, proximal ends of the clip arms received within a channel of a capsule to be moved between an open configuration and a closed configuration. A proximal end of the capsule including a plurality of connecting elements extending proximally therefrom. Each of the connecting elements including a hook along a proximal portion thereof. An applicator includes an elongated flexible member and a control member extending therethrough, the control member configured to be connected to the clip arms to move the clip assembly between the open and closed configurations, the elongated flexible member including a bushing including a first ramped portion and a necked portion extending proximally from the first ramped portion, a proximal end of the first ramped portion including a lip configured to engage the hook when the connecting elements are crimped thereover.