Abstract: A modular seat loading system for loading of various driver seats onto an off-road vehicle (ORV), forming a modular wheelchair-accessible ORV. The modular system includes controllable length-adjustment devices, configured to controllably adjust angular position of a floor of the ORV, by controlling length thereof, for switch ably achieving ORV modes: a load mode in which a floor structure of the ORV is tilted forming a non-zero angle ??????? the ORV floor and a ground surface, for removably loading a wheelchair or a wheel-less seat for serving as a driver seat; and a drive mode in which the ORV floor structure is lifted from the ground. The modular seat loading system also includes a load controller configured at least for adjusting length of the length-adjustment devices. Each of the length-adjustment devices is also configured and used for movement suspension of the ORV by enabling natural expansion and contraction responsive to ORV movements and road conditions.

Abstract: A caster-wheel assembly (100; 200) for a vehicle, for example a wheelchair or powered wheelchair. The caster-wheel assembly comprises a switch (13) coupled to a housing (3); a castering wheel bracket (9) configured to receive a wheel (10), wherein the bracket is rotatably mounted about a caster pivot axis (28) with respect to the housing; biasing means (15) configured to provide a biasing force such that the wheel bracket is biased away from the housing; and a switch-actuating member (13) coupled to the wheel bracket such that movement of the wheel bracket towards the housing and against the biasing force causes the switch-actuating member to actuate the switch.

Abstract: A wheelchair structure includes a seat body, a rear wheel bracket, a push rod device, and two relatively arranged front wheel assemblies, where the front wheel assembly includes a support member and a first wheel body mounted at the bottom end of the support member, the seat body and the rear wheel bracket are rotatably connected between the support members of the two front wheel assemblies, the push rod device includes a push rod and a driving mechanism for driving the push rod to make a telescopic movement, a first end of the push rod is rotatably connected with the bottom of the seat body, a second end of the push rod is rotatably connected with the rear wheel bracket, the push rod makes the telescopic movement to drive the seat body to rotate between the support members of the two front wheel assemblies.

Abstract: A mechanical type lifting shifter provided below a wheelchair body, including a bottom supporting assembly having a pair of oppositely arranged supporting members and gear rack columns provided on the supporting members; a movable upper supporting assembly having movable supporting members slidably sleeving the gear rack columns; a gear roller assembly having a rotating shaft and a pair of lifting gears provided on the two end portions of the rotating shaft; two ends of the rotating shaft are respectively and fixedly connected to a pair of movable supporting members and support the movable supporting members, and the lifting gears are engaged with the gear rack columns; a pedal transmission assembly mounted on the rotating shaft and in transmission connection with the rotating shaft; and a pedal clutch assembly connected to the pedal transmission assembly to switch clockwise and anti-clockwise motion transmission between the pedal transmission assembly and the rotating shaft.

Abstract: Methods using a motor, and a rolling tube or rod of sufficient strength to apply a pull force on one side of a sheet on the bed with the patient lying on the sheet to help pull up the patient on his bed or turn patients on his side with little manual effort. Patients having mobility issues under care in homes, nursing-homes or hospitals have to be regularly pulled up and turned on their sides to make them comfortable and to avoid formation of bed sores among other reasons. Currently this is done manually by nurses or caregivers. These simple but strenuous operation has been the cause of back problems for many caregivers. The current method is a way to reduce or eliminate this cause of injury to caregivers by providing a mechanized help for the operations.

Abstract: Systems and methods for tracking unintentional high amplitude muscle movements of a user and stabilizing a handheld tool are described. The method may include detecting motion of a housing of the handheld tool when manipulated by a user while the user is performing a task with a user-assistive device attached to an attachment arm of the handheld tool, and storing the detected motion in a memory of the handheld tool as motion data. Furthermore, the method may include controlling a first motion generating mechanism and a second motion generating mechanism by generating a first motion signal and a second motion signal that respectively drive the first motion generating mechanism in a first degree of freedom and the second motion generating mechanism in a second degree of freedom to stabilize motion of the user-assistive device attached to the attachment arm of the handheld tool.

Abstract: A soft wearable muscle assisting device has at least a wearable body interface and attached thereon elements of active and passive components, adapted to together assist a user in changing or maintaining a position of a first body part articulated to a second body part. The wearable body interface comprises at least two gar-ment portions. The active and passive components comprise at least one actively powered element. The passive components comprise at least a first passive component and a second passive component that both extend between the at least two garment components and comprise elastic material for storing energy provided by the user and/or by the at least one actively powered element. The first and a second passive components are arranged on opposite sides of a joint of the body.

Abstract: An example photoacoustic system for neurostimulation includes a light producing device for producing light of a specific wavelength. At least one nanotransducer is binded on a surface of a neuron. The nanotransducer converts the light with the specific wavelength into at least one acoustic wave at or near the neuron.

Abstract: A stabilizing medical belt or harness method and apparatus for averting injury in individuals that are prone to falls is configured to be worn by the user as a belt or harness and operated autonomously. Power is preferably provided by a battery pack located on the belt or harness. The invention includes a plurality of gyroscopic drives that produce a strong stabilizing effect when activated by a central computer that detects when the user is about to slip or fall. The medical stabilizer belt or harness will also aid patients in physical therapy by assisting in balance during recovery.

Abstract: An improved walking device is disclosed wherein the device comprises an elongated body, a movable arm coupled to the elongated body, a power source connector, a first sensor, a releaser, a first spring, wherein the first sensor is capable of detecting an orientation of the device and producing an electronic signal based on the orientation, wherein the electronic signal is capable of at least partially causing a movement of the releaser, wherein the releaser is capable of nudging the movable arm away from a resting position, and wherein the first spring is capable of causing the movable arm to rotate to a deployed position.

Abstract: A fall arresting lift machine has a gantry upon casters, a power source upon the gantry, a drive with a motor upon the gantry in communication with the power source, a controller in communication with the motor and the power source, a vertical strap paying out from the drive motor, a harness upon the strap, and the harness is suitable for wearing by a user. The gantry includes feet, housings, uprights, elbows, braces, and a union. The harness has straps for over both shoulders of the user and a belt and inertial measurement units upon the straps. The drive and controller cooperate to assist a user to sit and to stand, and to detect abrupt acceleration typical of a fall, and arrest the fall. The casters swivel, or alternately select wheels remain in fixed orientation.

Abstract: Disclosed herein are novel embodiments of progressive mobility aid devices. Such progressive mobility aid devices are designed to progress through a variety of configurations to accommodate the use of the progressive mobility aid device in a safe and secure manner as the user of the progressive mobility aid device traverses a variety of surfaces and terrain such as traversing irregular surfaces including sidewalks and stone-based surfaces; loose surfaces and terrain including gravel and sand; soft surfaces including wet ground and carpeted surfaces; and variable gradient surfaces including stairs and inclining or declining surfaces and terrain. The progressive mobility aid devices accommodate such uses with an articulating design that provides for front legs of the progressive mobility aid device to be pivotably adjusted with respect to the rear legs of the progressive mobility aid device, and with wheel assemblies that are selectively deployable and retractable.

Abstract: The present disclosure relates to devices and systems related to a modular leg component for a mobility walker. Namely, a device including a leg component that includes a first surface and a second surface is described. The first surface and the second surface may be constructed from materials with a different hardness from one another. The surfaces are configured to be movable relative one another. For example, at least one of the first surface or the second surface is rotatable about an axis such that in a first configuration the first surface is arranged to contact a ground surface and in a second configuration the second surface is arranged to contact the ground surface.

Abstract: Multipurpose tactile warning panels for use in pedestrian walkways, and in particular tactile warning panels that are designed and built with multifunction/multipurpose capabilities that serve the visually impaired and enable the deployment of smart city technology by integrating tactile warning systems and subsurface enclosures that can withstand pressures of five (5) tons up to and exceeding sixty (60) tons and incorporate small cells, beacons, sensors, Fog Computing, electric energy generation, rechargeable power supplies, wireless M2M communication and a plethora of other smart city technologies.

Abstract: A method for performing cardiopulmonary resuscitation (CPR) includes elevating the head, heart and shoulders of an individual from a starting elevation angle to a final elevation angle greater than zero degrees relative to horizontal while performing CPR by repeatedly compressing the chest. The method includes elevating the brain within a time period selected to be slow enough to permit a sufficient amount of blood to flow to the brain throughout the elevation time period. The method also includes regulating the intrathoracic pressure of the individual while performing CPR. The performance of chest compressions is stopped and after stopping the performance of chest compressions, the head, heart, and shoulders are promptly from the final elevation angle within a timeframe selected to prevent significant drainage of blood from the brain until the head, heart and shoulders are lowered.

Abstract: A system for monitoring performance of a resuscitation activity on a patient by an acute care provider is provided. The system includes: a first wearable sensor configured to sense movement of a first portion of an acute care provider's hand; a second wearable sensor configured to sense movement of a second portion of the acute care provider's hand; and a controller. The controller is configured to: receive and process signals representative of performance of a resuscitation activity from the first sensor and the second sensor; identify from the processed signals information indicative of at least one of a relative distance, a relative orientation, a change in relative distance and a change in relative orientation between the first sensor and the second sensor during performance of the resuscitation activity; and determine at least one resuscitation activity parameter based, at least in part, on the identified information.

Abstract: Methods for treating fluid overload in a subject comprise shifting fluids directly and non-invasively from an interstitial compartment of the subject to skin of the subject through controlled local sweating. Methods of the invention allow for removal of excess fluid from the interstitial compartment of the subject and treat fluid overload in the subject. Sweat stimulation systems comprise a chamber and first and second relative humidity sensors. The chamber is sized to fit around a body part of a subject, comprises an inlet and an outlet, and is configured such that air flows through the chamber from the inlet to the outlet. The first relative humidity sensor is operably located inside the inlet, and the second relative humidity sensor is operably located proximate the outlet.

Abstract: A soaking chair comprising: a seat surface and a support structure; wherein the chair is designed for use in a shower; and wherein the seat surface comprises a soaking reservoir. The chair provides hydrotherapy to the anogenital, hip, buttocks, and/or lower back areas.

Abstract: Provided is a method for locating a human target using superficial vein characteristics, which includes acquiring a model displaying both of the human target and superficial veins; projecting the model on a body surface where the superficial veins are located, so that a ratio of a projection on the body surface to actual dimensions of a human body is (0.9-1.1):1; and adjusting a position of the projection of the model, observing the superficial veins, and making at least two of the superficial veins coincide with veins in the projection of the model, and determining that a position of the human target in the projection of the model is a projection of the human target on the actual body surface.

Abstract: This invention comprises a mounted unit that combines the healing power of touch with functional, multi-faceted human engineering body manipulation and stress relief by incorporating the most basic principles of massage, acupressure, reflexology, rubbing/scratching, Shiatsu, and other health improvement techniques to provide the user with an easy-to-use, self-administrable stimulation experience. The unit contains a plurality of generally domed protrusions from each of which extends a nail-like rib running through the center of the domed surface, which perform the massaging experience when a user rubs his or her back against it at a pressure desirable to the user. The mounted unit can comprise a removable handheld unit that increases the body areas which can be massaged by the invention and a hinged door, behind which can be stored specialized attachments that are removably fastenable onto the protrusions for more focused massage.

Abstract: A massaging device (100) with a massaging surface and a plurality of massaging elements (101, 102, 103) moveable relative to each other; characterized in that the massaging surface is adapted such that when applying the massaging surface to a skin surface (111) and moving the massaging elements (101, 102, 103) relative to each other, two differently directed forces are simultaneously exercised by the massaging elements (101, 102, 103) on the skin surface (111) thereby causing simultaneous pinching and stretching of the skin surface (111) present in between the massaging elements (101, 102, 103).

Abstract: A pneumatic massage system includes a source of pressurized air, a fluidic switching module in communication with the source of pressurized air, a first bladder in communication with the fluidic switching module, a second bladder in communication with the fluidic switching module, and a third bladder in communication with the fluidic switching module. The fluidic switching module is configured to direct air from the source of pressurized air to each of the first bladder, the second bladder, and the third bladder in a predefined sequence. The predefined sequence includes inflating the first bladder, inflating the second bladder while deflating the first bladder, and inflating the third bladder while deflating the second bladder.

Abstract: A dispensing container and adapter system for use with a planetary mixer is disclosed. The dispensing container has a longitudinal axis and a transverse axis. The dispensing container may include a nozzle and a removable cap to cover the nozzle. The removable cap may have a first width dimension measured along the transverse axis. The dispensing container may include a body having a second width dimension measured along the transverse axis. An adapter may receive the dispensing container. The adapter may include a cavity to receive the removable cap. The cavity may have a cavity width that exceeds the first width dimension. The adapter may also include a recess for receiving a portion of the dispensing container. The recess may extend from the cavity. At least a portion of the recess may have a width dimension smaller than both the first width dimension and the second width dimension.

Abstract: Protective locking systems for source vials which helps prevent mishandling of liquid medication to be removed from source vials and used in an injection device, such as a wearable injection device or a syringe. The protective locking systems include at least a key, a locking cap and a slide guard, each of which includes an opening sized at least large enough to receive a needle therethrough.

Abstract: Systems and methods for the transfer of medical fluid are provided. A medical fluid transfer system may comprise a pump configured to transfer fluid through a tube assembly having a first connector configured to couple to a source container and a second connector configured to couple to a target container. The medical fluid transfer system may also comprise a destination sensor configured to output information about the target container. The medical fluid transfer system may further comprise a control system configured to operate the pump based on an operational setting associated with fluid volume; receive measurement data representing a measurement of the target container by the destination sensor, and adjust the operational setting based on an observed volume of fluid transferred to the target container.

Abstract: An assembly fixture device for attaching a vial adapter to a vial includes a base, a support member secured to the base, a handle connected to the support member, a vial adapter grip assembly connected to the handle and comprising an adapter grip member configured to engage and hold a vial adapter, and a vial grip assembly connected to the base comprising first and second grip members that are movable relative to each other and configured to engage and hold a vial. The first grip member is biased toward the second grip member to provide a vial engagement force, where the vial engagement force is about constant when a distance between the first and second grip members is less than 40 mm.

Abstract: A reconstitution device includes a body, a first piercing member located at a first end of the body, and a receptacle located at the second end of the body. The receptacle includes a collar configured to engage a vial, and a cap extending from the collar and holding a second piercing member. The second piercing member is disposed within the collar. The reconstitution device includes a first fluid pathway formed within and extending from the first piercing member to the second piercing member. The reconstitution device includes a second fluid pathway formed within and extending from the second piercing member to a portion of the body between the first piercing member and the second piercing member.

Abstract: A sealing element is received between a connector and an attachment member. The sealing element includes a foot section received by a recess of the connector, a shoulder engaging an inner surface of the attachment member, and a flange engaging a support surface of the connector. The sealing element also includes a cylindrical body extending from the shoulder to the flange along an insertion direction and, where the cylindrical body deforms to create a flow path through the sealing element, and a sealing head defines an opening that transitions from a closed state to an open state when the cylindrical body deforms.

Abstract: The present invention relates to a disc for use in a delivery device for medication units, such as a pills or tablets or portions thereof, comprising a substantially disc-shaped body, comprising means to be engaged for rotation of the disc at least one opening, spaced from the centre of the disc and preferably near the edge of the disc, for holding at least part of the medication unit wherein the at least one opening for holding at least a part of the medication unit is located at a distance from the contour of the disc-shaped body and is thus enclosed by the substantially disc-shaped body.

Abstract: The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: Leave-on oral care compositions comprising a hyaluronic acid, and a gum-strengthening polyol are provided for promoting Gum Health of a user.

Abstract: The present invention includes a low dose and sustained release formulation of a mitochondrial uncoupling agent The compositions of the invention are useful for preventing or treating a disease or disorder, such as non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, insulin resistance and/or diabetes, in a subject in need thereof.

Abstract: Nutritional products having improved cohesiveness of food boluses and methods of making and using same are provided. The nutritional products may include nutritional compositions and high molecular weight, water-soluble polymers such that the nutritional products have extensional viscosities that provide improved cohesiveness to the nutritional products and Trouton ratios of at least 6. Methods of administering such nutritional products to patients having impaired swallowing ability and/or dysphagia are also provided.

Abstract: The present invention involves a novel method for treatment of chronic kidney disease comprising administering a compound that induces a stress protein response in a patient, and administering a potent antioxidant if the patent's response is below a predefined level. It also involves a quantitative measure for determining a patient's antioxidant reserve capacity.

Abstract: A pharmaceutical composition is described. The composition comprises: (i) a drug component consisting of salmeterol xinafoate and fluticasone propionate. and (ii) a propellant component at least 90 wt % of which is 1,1-difluoroethane (HFA-152a). The drug component is the sole drug component in the pharmaceutical composition.

Abstract: This disclosure relates to administration of a combination of: 1) about 100-110 mg, about 104-106 mg, or about 105 mg of bupropion hydrochloride, or a molar equivalent amount of a free base form or another salt form of bupropion; and 2) about 40-50 mg, about 44-46 mg, or about 45 mg of dextromethorphan hydrobromide, or a molar equivalent amount of a free base form or another salt form of dextromethorphan in certain patient populations, such as patients having moderate renal impairment, patients receiving a concomitant strong CYP2D6 inhibitor, patients who are known CYP2D6 poor metabolizers, those in need of an NMDA antagonist that does not cause dissociation, and those at risk of QT prologation.

Abstract: A dosage form of lacosamide and a pharmaceutical dosage form thereof is disclosed. The dosage form includes an extended release portion and optionally an immediate release portion. Also provided are methods of providing extended release of lacosamide and treatment of a neurological or psychiatric disease or condition.

Abstract: The present disclosure relates to a method for treating certain types of tumors or cancers, such as plexiform neurofibromas (PN), plexiform neurofibromas associated with neurofibromatosis type 1 (NF1-PN), by orally administering an effective amount of mirdametinib to the patient, where an amount of mirdametinib is administered on the first day of treatment to provide (i) an AUC0-tau less than 400 ng h/mL, (ii) a Cmax no more than 40 ng/mL, or (iii) both.

Abstract: A method for amelioriation of, or prophylaxis against, a viral infection comprising administering to a patient in need of treatment a therapeutically effective amount of 5 aminolevulinic acid, optionally with at least one of cucumarin nano, zinc, vitamin C and methylene blue, and compositions thereof. Such compositions may be used for the treatment of coronavirus infections, including the SARS-CoV-2 virus, and/or rhinoviruses.

Abstract: Botanical extracts are provided, which comprise ethanol extracts of Nannochloropsis algae having between 1 wt % and 50 wt % polar lipids and between 45 wt % and 60 wt % fatty acids, wherein the fatty acids comprise more than 10 wt % of eicosapentaenoic acid (EPA) as triglyceride conjugates and/or diglyceride conjugates, and less than 15 wt % EPA as free fatty acids. EPA level may reach up to 90 wt %, and the botanical extract may be fluid at room temperature. Growth conditions are configured, adjusted and monitored to promote EPA formation in the cell vacuoles, resulting in a high proportion of EPA as tri/di-glyceride conjugates, as well as in a high concentration of ?-3 fatty acids, which merely requires gentle extraction procedures to reach the final products, thereby maintaining the biochemical of the compounds without excessive modifications.

Abstract: Provided are formulations, methods, and devices for providing a hydrogel. The formulations and resulting hydrogels may be used for treating various disorders, including ocular disorders. In certain embodiments, the hydrogel is formed from formulations comprising (a) a nucleo-functional polymer that is a biocompatible polyalkylene polymer substituted by (i) a plurality of —OH groups, (ii) a plurality of thio-functional groups —R1—SH wherein R1 is an ester-containing linker, and (iii) optionally one or more —OC(O)—(C1-C6 alkyl) groups, such as a thiolated poly(vinyl alcohol) polymer; (b) an electro-functional polymer that is a biocompatible polymer containing at least one thiol-reactive group, such as a poly(ethylene glycol) polymer containing alpha-beta unsaturated ester groups; and (c) one or more pharmaceutically active agents. In certain embodiments, the hydrogel is formed at a targeted sited using methods and/or devices for focal administration of the formulations and/or hydrogels described herein.

Abstract: A 9-fluoro-dibenzo[b,g]indeno[1?,2?:3,4]fluoreno-[1,2-d]oxonine-5,11,16,21-tetraone compound, its synthesis, and its use as an antimicrobial agent.

Abstract: Provided herein are compositions and methods for administration of sulcardine to a subject in need thereof.

Abstract: Provided herein are small molecule inhibitors of ASH1L activity and small molecules that facilitate ASH1L degradation and methods of use thereof for the treatment of disease, including acute leukemia, solid cancers and other diseases dependent on activity of ASH1L.

Abstract: This invention provides novel compositions comprising an anti-inflammatory agent and a mydriatic agent suitable for intraocular use, particularly ketorolac or pharmaceutically salts thereof and phenylephrine or pharmaceutically salts thereof, which are free of any buffering agent and yet, surprisingly, maintain stability for significant periods of time (e.g., at least about 3 months). The present invention also relates to a process of preparing such compositions and use thereof, e.g., in combination with intraocular ophthalmologic irrigation solutions.

Abstract: The present invention relates to pharmaceutically acceptable salts of [3-(4-{2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-propyl]-diethylamine (“COMPOUND I”) useful in the treatment of RAGE mediated diseases.

Abstract: In one aspect, the disclosure relates to compositions and methods for dispersing exiting Salmonella biofilms and inhibiting formation of Salmonella biofilms. In various aspects, the disclosed compositions can be used in methods of treating a persistent Salmonella infection, including an asymptomatic infection. Such infections can colonize a variety of tissues, including the gall-bladder. Also disclosed are methods of treating typhoid fever. Also disclosed are methods for mitigating or preventing secondary outbreaks of typhoid fever by treating asymptomatic subjects who had been symptomatic for typhoid fever at a previous time. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: Provided herein are methods of treating Tourette Syndrome in a subject in need thereof by administering to the subject compositions comprising a PDE10 inhibitor.

Abstract: The present disclosure relates to HIF-1? prolyl hydroxylase inhibitors, compositions which comprise the HIF-1? prolyl hydroxylase inhibitors described herein and to methods for controlling, inter alia, Peripheral Vascular Disease (PVD), Coronary Artery Disease (CAD), heart failure, ischemia, and anemia.

Abstract: The present invention relates to a compound according to general formula (I), which acts as an inhibitor of PqsR (the currently only known receptor for the Pseudomonas Quinolone Signal (PQS)); to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to uses of said compound(s), including the use as a medicament, e.g. the use in the treatment or prophylaxis of a bacterial infection, especially a Pseudomonas aeruginosa or Burkholderia infection.