Abstract: A laparoscopic medical device includes an oximeter sensor at its tip, which allows the making of oxygen saturation measurements laparoscopically. The device can be a unitary design, wherein a laparoscopic element includes electronics for the oximeter sensor at a distal end (e.g., opposite the tip). The device can be a multiple piece design (e.g., two-piece design), where some electronics is in a separate housing from the laparoscopic element, and the pieces (or portions) are removably connected together. The laparoscopic element can be removed and disposed of; so, the electronics can be reused multiple times with replacement laparoscopic elements. The electronics can include a processing unit for control, computation, or display, or any combination of these. However, in an implementation, the electronics can connect wirelessly to other electronics (e.g., another processing unit) for further control, computation, or display, or any combination of these.

Abstract: A laparoscopic medical device includes an oximeter sensor at its tip, which allows the making of oxygen saturation measurements laparoscopically. The device can be a unitary design, wherein a laparoscopic element includes electronics for the oximeter sensor at a distal end (e.g., opposite the tip). The device can be a multiple piece design (e.g., two-piece design), where some electronics is in a separate housing from the laparoscopic element, and the pieces (or portions) are removably connected together. The laparoscopic element can be removed and disposed of; so, the electronics can be reused multiple times with replacement laparoscopic elements. The electronics can include a processing unit for control, computation, or display, or any combination of these. However, in an implementation, the electronics can connect wirelessly to other electronics (e.g., another processing unit) for further control, computation, or display, or any combination of these.

Abstract: A medical device for detecting at least one analyte in a body fluid is disclosed.

Abstract: A medical device for detecting at least one analyte in a body fluid is disclosed.

Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.

Abstract: A sensor implanted in tissues and including a sensing enzyme takes an electrical measurement and compares it to reference curves for the voltage current relationship. The sensor determines whether molecular compounds are present which interfere with the detection of the molecule of interest. If interfering species are found, the measurement voltage is set in a low range to reduce errors, while if the interfering species are not found, the measurement voltage is set in a high range to increase the detected signal.

Abstract: A fluid control device includes an inlet configured to be placed directly or indirectly in fluid communication with a bodily fluid source and an outlet configured to be placed in fluid communication with a fluid collection device. The fluid control device has a first state in which a negative pressure differential produced from an external source such as the fluid collection device is applied to the fluid control device to draw an initial volume of bodily fluid from the bodily fluid source, through the inlet, and into a sequestration portion of the fluid control device. The fluid control device has a second state in which (1) the sequestration portion sequesters the initial volume, and (2) the negative pressure differential draws a subsequent volume of bodily fluid, being substantially free of contaminants, from the bodily fluid source, through the fluid control device, and into the fluid collection device.

Abstract: A fluid control device includes an inlet configured to be placed directly or indirectly in fluid communication with a bodily fluid source and an outlet configured to be placed in fluid communication with a fluid collection device. The fluid control device has a first state in which a negative pressure differential produced from an external source such as the fluid collection device is applied to the fluid control device to draw an initial volume of bodily fluid from the bodily fluid source, through the inlet, and into a sequestration portion of the fluid control device. The fluid control device has a second state in which (1) the sequestration portion sequesters the initial volume, and (2) the negative pressure differential draws a subsequent volume of bodily fluid, being substantially free of contaminants, from the bodily fluid source, through the fluid control device, and into the fluid collection device.

Abstract: Systems, devices, apparatus, methods, and computer-readable storage media for developmental assessment using eye tracking are provided. In one aspect, a system for development assessment via eye tracking includes: a patient-side computing device having a screen for presenting visual stimuli to a patient, an eye-tracking device integrated with the patient-side computing device and configured to collect eye-tracking data of the patient while the visual stimuli are presented to the patient on the screen of the patient-side computing device, and an operator-side computing device configured to present a user interface for an operator to communicate with the patient-side computing device.

Abstract: Proposed are concepts of identifying physiological stress of a user of a virtual reality environment by displaying to the user a virtual object at an object location within the virtual reality environment and instructing the user to interact with the displayed virtual object. A measure of physiological stress may then be determined based on a detected parameter of the user's movement in response to the instruction, and the measure of physiological stress may be associated with a part of the user's body based on the object location.

Abstract: A mental state awareness system comprises a non-invasive brain interface assembly configured for detecting brain activity of a user, a processor configured for determining a mental state of a user based on the detected brain activity, and a biofeedback device configured for automatically providing biofeedback to the user indicative of the determined mental state of the user.

Abstract: Described herein are methods, software, systems and devices for detecting the presence of an abnormality in an organ, tissue, body, or portion thereof of a subject by analysis of the electromagnetic fields generated by the organ, tissue, body, or portion thereof.

Abstract: A system and method for a wearable field sensing device for biological electromagnetic (EM) field measurement including: a wearable structure; a biological sensor array, on or within the wearable structure, such that each biological sensor is situated adjacent to the body of the user, and wherein each biological sensor includes at least one ferromagnetic resonance (FMR) sensor; a power system, providing the power for the system; and control circuitry, electrically coupled to the system. The FMR sensor comprises an acoustically driven ferromagnetic resonance (ADFMR) sensor. The system may additionally include sensor shielding and an ambient sensor array to detect a block external fields.

Abstract: A device, system, and method for mapping myocardial tissue, such as epicardial tissue on the right ventricle. A system for mapping myocardial tissue may include a mapping device having a distal portion that includes a distal assembly sized and configured to be positioned within the pericardial space. The distal assembly may include an expandable shell, at least one inflatable or expandable element within the expandable shell, and a mapping electrode assembly. Inflation or expansion of the at least one inflatable or expandable element, and therefore expansion of the expandable shell, within the pericardial space may provide sufficient force of the mapping electrodes against the myocardial tissue being mapped. The system may also include a delivery sheath with a retention element for controllably retracting the device within the sheath during delivery and removal of the device from the pericardial space.

Abstract: A catheter is disclosed comprising: a connector including a plurality of first contacts and one or more second contacts; a shaft including a plurality of electrodes, each electrode being coupled to a different one of the plurality of first contacts; a memory coupled to at least one of the second contacts, wherein the memory is configured to: store a pinout map identifying an order in which the plurality of electrodes is coupled to the plurality of first contacts; and provide the pinout map to an external device via one or more of the second contacts after the connector is coupled to the external device.

Abstract: An automatic noise signal interval detection method and device are provided, and the method includes receiving input data and generating initial data in a time-frequency domain, calculating power for each epoch for each channel of the initial data, generating a power graph for a specific frequency region of each channel based on the power for each epoch, generating a baseline based on an average of each channel value on the power graph, and determining, as a noise signal interval, an interval exceeding a predetermined threshold based on the baseline on the power graph.

Abstract: A method of providing physiological self-regulation challenges prior to participating in a series of activities or exercises at a series of predefined locations includes determining a physiological goal associated with each location. A sensing device measures a physiological state of a user, and a mobile communication device communicates to a user whether or not the user has achieved the physiological goal for the challenge. The level of difficulty of the physiological goal may be reduced if the user does not meet the goal. The physiological goal may comprise a brain state that is conducive to learning, and the sensing device may be configured to measure brain state values representing cognitive engagement. Upon achievement of each physiological goal, the participant is provided with a reward such as information concerning the current predefined location and/or information concerning the next predefined location.

Abstract: A system and method of detecting eye movements of a subject for the diagnosis of neurological disorders. The method includes tracking eye movements of the subject, identifying microsaccades from the tracked eye movements, and characterizing microsaccade dynamics of the identified microsaccades to determine one or more parameters, such as microsaccade direction, microsaccade velocity, microsaccade magnitude, microsaccadic peak velocity-magnitude relationship, microsaccade duration, and intersaccadic intervals. The method also includes comparing the one or more determined parameters with a corresponding control parameter, assessing the comparison to determine differences between the one or more determined parameters and the corresponding control parameters, and generating a report including the diagnosis of neurological disorder based on the assessment.

Abstract: Methods and apparatuses are described herein for treating a patient with mild cognitive impairment (MCI) or dementia by one or more digital therapeutics. For example, a patient. who has been diagnosed with the MCI or dementia may administer one or more digital therapeutics to the patient to improve a plurality of neurohumoral factors that cause the MCI or the dementia of the patient. The digital therapeutics may include one or more digital instructions that are generated to treat at least one imbalance of the plurality of neurohumoral factors based on at least one neurohumoral change among the plurality of neurohumoral factors by the patient's performance of the one or more digital instructions. The one or more digital instructions may include at least one of an execution environment setting, a lifestyle change, learning, exercising, or affirmation/achievement task.

Abstract: Methods, systems and devices for evaluating the integrity of a uterine cavity. A method comprises introducing transcervically a probe into a patient's uterine cavity, providing a flow of a fluid (e.g., CO2) through the probe into the uterine cavity and monitoring the rate of the flow to characterize the uterine cavity as perforated or non-perforated based on a change in the flow rate.

Abstract: Methods for assessing a skin surface of a patient and associated systems and devices are described herein. A method configured in accordance with embodiments of the present technology can include, for example, receiving a three-dimensional data set representative of the patient's skin surface and determining a boundary of a feature of the patient's skin in the three-dimensional data set. The method can further include determining, with a processor, a three-dimensional surface area of the feature within the boundary. In some embodiments, the method can also include identifying a plurality of sub-regions within the boundary and identifying one or more tissue types in each sub-region.

Abstract: A method for detecting a respiratory event of a subject comprises: receiving a bio-impedance measurement signal (S2) dependent on respiratory action from the subject; extracting (306) at least one time-sequence of the bio-impedance measurement signal (S2); and for each extracted time-sequence: comparing (308) the bio-impedance measurement signal (S2) with each of a plurality of machine learning models in an ensemble of machine learning models to form a set of predictions of occurrence of a respiratory event, wherein each prediction is based on comparing the bio-impedance measurement signal (S2) with one machine learning model, wherein each model correlates features of time-sequences of a bio-impedance measurement signal (S2) with presence of a respiratory event and wherein each model is trained on a unique data set of training time-sequences; deciding (310) whether a respiratory event occurs in the extracted time-sequence based on the set of predictions.

Abstract: Systems and methods for treating a subject with a psychiatric disorder are provided in which a therapy session is conducted. In the therapy session, each respective expression image in a plurality of expression images is sequentially displayed. Each expression image is independently associated with an expression. The successive display of images is construed as a tiled series of expression image subsets, each consisting of N expression images. Upon completion of the display of each respective subset, the user is challenged as to whether the first and the last images in the respective subset exhibit the same emotion. A score is determined for the respective subset based on whether the subject learned to respond correctly. The number of images in each subset is adjusted to a new number based on these scores. A treatment regimen is prescribed to the subject for the psychiatric disorder based at least in part on the scores.

Abstract: A device for treating chest wall injuries, including rib fractures, flail chest injuries or surgical incisions is described herein. The device includes a localized airtight compartment external to the chest wall and fully covering the area of injury, and is capable of varying the pressure within the compartment, and providing dynamic real-time counter forces that act reciprocal to the intrathoracic pressure changes that occur during ventilation. In a preferred embodiment, the device has the capability of sensing the patient's chest wall motion created by ventilation, and includes a pressure control component capable of varying the pressure within the airtight compartment such that it opposes pressure changes within the chest. The apparatus would be particularly useful in preventing the paradoxical movement of flail chest injuries. The device would also lessen pain experienced by patients with thoracic injuries such as rib fractures and post operative suffering.

Abstract: A method for power management of a wearable device or an implantable device comprising a sensor, the sensor configured for providing a physiological information of a user, the sensor being further configured to be operated in at least two power modes comprising a first power mode and a second power mode, wherein in the first power mode the physiological information of the user is gathered and in the second power mode the sensor consumes less power than in the first power mode, the method comprising: receiving a signal being indicative of whether a health device which is configured to treat a health condition of the user is in use, wherein the health device is positioned at a different location with respect to the user than the wearable device or the implantable device; and based on the signal operating the sensor for a time duration in the first power mode; and operating the sensor in the second power mode thereafter.

Abstract: The present disclosure provides a method performed in an accessory device. The accessory device comprises an interface configured to communicate with one or more devices of an ostomy system. The interface comprises a display. The ostomy system comprises a monitor device, and/or an ostomy appliance configured to be placed on a skin surface of a user, wherein the ostomy appliance comprises the base plate. The method comprises displaying, on the display, a notification settings user interface comprising one or more control objects including a first control object, wherein the notification settings user interface is configured to adjust notification setting parameters of an ostomy user application.

Abstract: A method and an osseointegrated prosthesis system having an osseointegrated prosthesis member are provided having a monitoring system operably coupled to the osseointegrated prosthesis member configured to quantitatively assess the osseointegration of the osseointegrated prosthesis member, a wave-generating element coupled to the osseointegrated prosthesis member and configured to output guided waves along the osseointegrated prosthesis member interrogating an interface between bone and the osseointegrated prosthesis member, and a sensing system configured to sense a condition of the interface between bone and the prosthesis.

Abstract: Described are systems and methods that use one or more two-dimensional (“2D”) body images of a body to determine body fat measurements of that body. For example, a standard 2D camera of a portable device, such as a cell phone, tablet, laptop, etc., may be used to generate one or more 2D body images of a user. Those 2D body images, or image, may be processed using the disclosed implementations to determine a body fat measurement of the body represented in the image.

Abstract: An apparatus for measuring patient data includes a frame having a plurality of electrode hubs. Each hub can include one or more electrode members. The frame can be configured to receive a head of a patient. Each of the electrode hubs can have a single electrode member or a plurality of electrode members that extend from or are connected to an outer member for contacting a scalp of the head of the patient. The outer member can have at least one circuit configured to transmit data received by at least one of the electrode members to a measurement device via a wireless communication connection (e.g. Bluetooth, near field communication, etc.) or a wired communication connection.

Abstract: A garment shaped to approximate the abdomen of an expectant mother having a layered laminated conductive material adhered to the garment is disclosed. A portion of the laminated material is configured to directly contact the skin of the maternal abdomen to create an electrical signal connection. A portion of the layered laminated material comprises a stretchable circuit assembly having a substrate with an adhesive layer, a thermoplastic layer, a conductive layer and an encapsulating layer. A monitor controller is disposed about the garment and is configured to receive electrical signals from the circuit assembly and transmit information related to the electrical signals to a remote location.

Abstract: In various embodiments, an electronic device may include: a light receiver including light receiving circuitry, a light emitter including light emitting circuitry, a partition wall disposed between the light receiver and the light emitter configured to block light emitted by the light emitter from being directly incident on the light receiver, a film disposed above one surface of the light receiver, and a processor. The film may include a transmission region configured to transmit light of all wavelength bands and a selective blocking region configured to absorb light of a specific wavelength band. The processor may be configured to analyze light incident on the light receiver through the film.

Abstract: Systems, computer-implemented methods and/or computer program products that facilitate wearable multiplatform sensing are provided. In one embodiment, a computer-implemented method comprises: measuring, by a system operatively coupled to a processor, wirelessly on a nail plate, physiological data of an entity; integrating and synchronizing, by the system, the physiological data with other physiological data from one or more devices to form integrated physiological data; and analyzing, by the system, the integrated physiological data to detect one or more disorders.

Abstract: An apparatus and method for examining an organism surface includes a pliable member including a contact layer, a plurality of channels, and a reaction layer, wherein the plurality of channels are disposed between the contact layer and the reaction layer; each of the channels having a size in the range of micrometers and formed of biocompatibility materials, and the contact layer including a plurality of spherical projections having a size in the range of micrometers and formed of biocompatible materials, and the reaction layer including examining molecules and a reaction unit.

Abstract: A system, apparatus, and method using multiple complementary sensors for the monitoring and wireless communication of several respiration characteristics—that is badge-size, wearable on the outside of clothing, and non-invasive.

Abstract: A method of modifying contact status of one or more electrodes in a plurality of electrodes located on a medical device includes measuring an electrical characteristic of each electrode in the plurality of electrodes located on the medical device, determining a contact status for each electrode in the plurality of electrodes based on the measured electrical characteristic for the corresponding electrode, wherein the contact status is indicative of contact with adjacent tissue. The method further includes modifying the contact status of a first electrode in the plurality of electrodes based on the determined contact status of one or more other electrodes in the plurality of electrodes.

Abstract: A microsensor and method of manufacture for a microsensor, comprising an array of filaments, wherein each filament of the array of filaments comprises a substrate and a conductive layer coupled to the substrate and configured to facilitate analyte detection. Each filament of the array of filaments can further comprise an insulating layer configured to isolate regions defined by the conductive layer for analyte detection, a sensing layer coupled to the conductive layer, configured to enable transduction, and a selective coating coupled to the sensing layer, configured to facilitate detection of specific target analytes/ions. The microsensor facilitates detection of at least one analyte present in a body fluid of a user interfacing with the microsensor.

Abstract: A subcutaneously implantable device includes a housing, a first prong, and a second prong. A first electrode on the first prong is configured to contact the first lung. A second electrode on the device is configured to contact the first lung or a second lung. A third electrode on the second prong is configured to contact the heart or the tissue surrounding the heart. Sensing circuitry in the housing in electrical communication with the first electrode, the second electrode, and the third electrode is configured to measure an impedance in the first lung and/or the second lung, and/or a transthoracic impedance across the first lung and the second lung through the first electrode and the second electrode, and to measure an electrical signal from the heart through the third electrode.

Abstract: The invention comprises a system that monitors heart activity through embedded ECG sensors in a desk, and desk-related amenities such as a chair, a computer keyboard, a mouse, and a floor mat. The invention also comprises pressure sensors for monitoring a user's presence at the desk. Signals measured from the ECG or pressure sensors are transmitted (in a wired, or wireless fashion) to a computer processing device which applies algorithms to refine the collected signals, and passively estimate the user's ECG.

Abstract: Neural network based heart rhythm classifiers are described. The neural network is configured to receive an electrocardiogram segment and to output an indication of whether the electrocardiogram segment represents a heart rhythm that is suitable for treatment by a defibrillation shock. Preferably, the received electrocardiogram segment is not transformed or processed prior to its reception by the neural network and no features of the electrocardiogram are identified to the neural network. In some embodiments, the received electrocardiogram segment is the sole input to the neural network. In various embodiments, the neural network is configured to classify electrocardiogram segments obtained while CPR was being performed on the patient. Classifiers that output a characteristic of CPR are also described. Such outputs may include an indication of whether CPR was being performed while the ECG was being detected, compression depth, etc. The described classifiers are well suited for use in defibrillators.

Abstract: System and method for measuring dyslipidemia condition of a subject using thermal imaging is disclosed. The disclosed system and method includes thermal sensors for capturing thermal images and/or videos of a body part; and a processing engine to detect a predefined region of the body part in each frame of the captured images and/or videos. The processing engine segments one or more portions from the predefined region in each frame of the captured images and/or videos to identify a ROI comprising arteries in the segmented portions. Based on the identified region of interest, the engine extracts pixel values, representing biosignals, from each frame of the captured images and/or videos to determine parameters associated with a rate of atherosclerotic, levels of lipids and lipoproteins, and hemodynamic factors of the subject. Further a risk score for the dyslipidemia condition based on the determined parameters using computational models is measured.

Abstract: Provided are a system and a computer program for managing and predicting thyrotoxicosis using a wearable device. The system for predicting thyrotoxicosis is a system for predicting thyrotoxicosis using a resting heart rate, the system including a wearable device for measuring the heart rate of a patient at regular intervals, and a bio-signal computing device for receiving heart rate information from the wearable device, the bio-signal computing device outputting a warning alarm when a resting heart rate is greater than a reference heart rate when the patient is in a normal state.

Abstract: In some examples, a method includes receiving a signal indicative of a blood pressure of a patient and identifying at least one first portion of the signal comprising a first characteristic of the signal exceeding a first threshold. The method also includes identifying at least one first portion of the signal comprising a second characteristic of the signal exceeding a second threshold, the first characteristic being different than the second characteristic. The method further includes determining a filtered signal indicative of the blood pressure of the patient by excluding the at least one first portion and the at least one second portion from the signal. The method includes determining a set of mean arterial pressure values based on the filtered signal and determining an autoregulation status of the patient based on the set of mean arterial pressure values.

Abstract: An image processing apparatus according to an embodiment includes processing circuitry. The processing circuitry is configured to obtain three-dimensional image data of a brain acquired by performing a magnetic resonance imaging process. The processing circuitry is configured to generate a projection image rendering a micro bleed or calcification occurring in the brain by performing a projecting process on the three-dimensional image data in a range limited on the basis of a shape of the brain. The processing circuitry is configured to output the projection image.

Abstract: An incontinence detection alert system may include a bed configured to receive an occupant and at least one monitor configured to acquire data related to at least one of a status of the bed or a status of the occupant. An incontinence detection system may have circuitry to detect an incontinence event of the occupant. A controller may be configured to receive the data from the at least one monitor and to further receive data related to a time of the incontinence event. A remote device may be configured to receive an alert from the controller before a predicted time of a future incontinence event.

Abstract: A breathable package that allows a device or object disposed in the package to be sterilized, and maintains the sterile condition until the package is opened at the point of use. The package also provides a visual indication that the package seal integrity has not been compromised or that the package has been compromised or breached. The package includes a first material, such as a film, and a second non-woven material, such as non-woven high density polyethylene, that form opposing sides of the package.

Abstract: Extra-oral dental method and/or apparatus embodiments according to this application can generate cephalometric imaged by digital tomosynthesis. An extra-oral dental imaging system embodiment for creating a cephalometric image of at least part of a human skull can include an X-ray source, an imaging device suitable for producing multiple frames during at least part of an exposure; a memory for registering and/or storing said multiple frames; and a manipulator for displacing the imaging device along an exposure profile between multiple frames during said at least part of the exposure of said object. The imaging device has an active area having a long dimension m and a short dimension n, wherein the aspect ratio m:n is strictly inferior to 1.5.

Abstract: A nuclear medicine tomography system including: a detector carrier; a detector carrier housing including an inner space; a plurality of detector units, coupled to the detector carrier, each detector unit comprising: a detector camera; a cooling channel which guides air to the detector camera from the inner space; an exhaust channel which guides air from the detector camera to the inner space; a heat pump configured to cool air within the inner space.

Abstract: For calibration in medical emission tomography, the dosimeter and/or detector is calibrated in the field, such as at the clinic or other patient scanning location. To allow for a fewer number of calibration sources used in calibrating and/or assist in calibration for multispectral emission tomography, a calibration source includes multiple isotopes and/or a proxy source or isotope is used instead of the same isotope used in factory calibration.

Abstract: A method and system is disclosed for analyzing and evaluating image data of a subject. The image data can be collected with an imaging system in a selected manner and/or motion. More than one projection may be combined to generate and create a selected view of the subject. The evaluation may be a location determination of a member positioned within the subject.

Abstract: An intraoral imaging apparatus for tomosynthesis imaging has an x-ray source having a primary collimator that defines boundaries of a radiation field. A transport apparatus translates the x ray source along a path for tomographic imaging. An intraoral x-ray detector defines an imaging area for the radiation field. A positioning apparatus correlates the position of the intraoral detector to the position of a secondary collimator. One or more radio-opaque markers provided on a detector attachment is coupled to the detector, the one or more markers configured to condition acquired x-ray images to relate the spatial position of the intraoral x-ray detector to the x-ray source position, wherein the one or more markers are disposed within the defined imaging area. A control logic processor accepts image data from the detector and determines the relative location of the source with respect to the detector according to detected marker position.