Abstract: The present technology relates generally to dry powder formulations of antibodies specific for thymic stromal lymphopoietin (TSLP), as well as methods of treating asthma, using the dry powder formulations, suitably via pulmonary delivery.

Abstract: Provided herein are compositions and methods for treating respiratory and pulmonary vascular disease. In particular, provided herein are spray dried simvastatin for delivery to the lung.

Abstract: The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.

Abstract: A capsule shell contains 40 to 99% by weight of a core-shell polymer and 1 to 60% by weight of a cellulose. The core-shell polymer contains 50 to 90% by weight of a core, containing polymerized units of 65 to 75% by weight of ethyl acrylate and 25 to 35% by weight of methyl methacrylate; and 10 to 50% by weight of a shell, containing polymerized units of 45 to 55% by weight of ethyl acrylate and 45 to 55% by weight of methacrylic acid.

Abstract: This disclosure provides novel peptide hydrogels containing encapsulated nanoparticles comprising nucleic acid molecules (such as miRNA) that can undergo multiple gel-to-solution (gel-sol) and solution-to-gel (sol-gel) phase transitions, and their use, such as for controlled delivery of nucleic acid molecules to a subject.

Abstract: A hydrogel object includes a polymer and water, wherein the rate of mass loss is not greater than 20 percent by mass when the hydrogel object is left undone for one week at 25 degrees C. and relative humidity of 50 percent.

Abstract: A light emitting apparatus including a first light emitter including at least one first light emitting diode and a wavelength converter, and a second light emitter including at least one second light emitting diode, in which the first light emitting diode emits light having a central wavelength in a range of violet or blue, the second light emitting diode emits light having a central wavelength in a range of about 400 nm to 420 nm, the wavelength converter includes green and red phosphors to convert light of the first light emitting diode into the white light, in the white light, an irradiance of light emitted from the first light emitting diode is less than that from the red phosphor, and an irradiance of light emitted from the second light emitting diode is greater than that of the white light emitted from the first light emitter at the same wavelength.

Abstract: A control system in a UVC-based aircraft sanitization system for controlling the UVC-based aircraft sanitization system to maintain a desired UVC (ultraviolet C) radiation level at a target surface in an aircraft under varying operating conditions is disclosed. The control system includes a controller configured to: receive measured radiation feedback from a radiation measurement device (e.g., dosimeter) on the target surface that identifies a radiation level that is applied at the target surface by the UVC-based aircraft sanitization system; and generate a UVC source control command for UVC sources in the UVC-based aircraft sanitization system. based on the received measured radiation feedback, to control the UVC sources to increase or decrease radiation level output (e.g., identify the amount of increase or decrease from the UVC sources) to generate sufficient radiation to achieve the desired radiation level at the target surface.

Abstract: A self-sanitizing stylus for use in combination with a touch screen device and method of using the same is disclosed. The self-sanitizing stylus comprises a body including a component retaining enclosure and longitudinal member. The longitudinal member has a body defined between a distal end with a touch tip disposed thereon, and a proximal end secured with an operative end of the component retaining enclosure. At least one ultraviolet radiation emitting device is disposed on the body. The component retaining enclosure includes a power source and switch connected between the power source, and the ultraviolet radiation emitting device, which when pressed establishes an electrical connection between the power source and the ultraviolet radiation emitting device, which emits UV radiation to disinfect the body or portion thereof.

Abstract: A sterilization module including a main body, a circuit board disposed in the main body, a light source disposed on the circuit board to emit sterilizing light, and a transparent unit to protect the light source from an outside and including a material that transmits the sterilizing light, in which the light source includes a mesa including a first semiconductor layer, an active layer, and a second semiconductor layer, a first electrode electrically connected to the first semiconductor layer, and a second electrode disposed on the second semiconductor layer and electrically connected to the second semiconductor layer, in which the first electrode includes a first contact region disposed on the outer area of the first semiconductor layer and a second contact region at least partially surrounded by the mesa, and a distance between the transparent unit and the circuit board is greater than a height of the light source.

Abstract: A disinfecting glove includes: a glove body that can be made of nitril rubber; a disinfecting pad that includes a pad body with a disinfecting agent applied and optionally an adhesive layer, a scrubbing portion, a cleaning portion, and dusting portions, such that the disinfecting pad can be detachably or permanently positioned on a palmar side of the glove body, such that the disinfecting glove can be used to clean and disinfect a surface. Also disclosed is a disinfecting glove system including a pair of glove assemblies, each including a glove container and a disinfecting glove; and a disinfecting system including a plurality of pairs of disinfecting gloves; and a plurality of disinfecting shoe covers, each including a shove cover body and a disinfecting pad.

Abstract: Provided are mobile decontamination units and methods of using such units for decontaminating various areas, such as aircraft cabins. A mobile decontamination unit comprises at least one aerosol dispersing nozzle and at least one aerosol directing fan. The nozzle disperses disinfectant in the aerosol form, while the fan directed this aerosol to surfaces being decontaminated. Aerosol dispersing parameters, such the nozzle and fan orientations, dispersing rate, fan speed, and the like, are determined based on area characteristics. Specifically, orientations of different surfaces, temperature, humidity and/or other like characteristics may be considered. Some characteristics may be obtained by the mobile decontamination unit after its deployment in the area, such as using its sensors. Other characteristics, such as area layout, may be preloaded to the mobile decontamination unit prior to its deployment. The dispersing parameters are determined to ensure through decontamination of the surfaces in the area.

Abstract: Mobile apparatus and methods for ultraviolet (UV) light sanitization of an aircraft. The mobile apparatus generally comprises a mobile platform, such as a trolley, that has integrated therewith circuitry and devices that control and actuate ultra-violet C-spectrum (UV-C) light sources that are mechanically coupled to the trolley. The proposed mobile apparatus includes a controller that receives input from an operator and, optionally, from dosimeters mounted on the proposed system and/or within the aircraft. Based on the inputs received, the controller provides guidance to the operator in the form of alerts and messages, as well as automatically adjusting components of the mobile apparatus to adapt itself to a specific aircraft type.

Abstract: A sanitizer using radiation comprises a hollow housing with an aperture, the housing being generally opaque to the radiation utilized. Mounted to the interior surfaces of the housing are radiation sources that produce radiation when powered. In operation, multiple objects to be sanitized are placed within the interior and the radiation sources powered, thereby sanitizing by radiation any pathogens present on the objects be irradiated. An easily adjustable shelving system that is substantially non-opaque to the radiation utilized, such as wire shelving with minimal opaque surfaces, may be used to support the objects to be sanitized. Depending on size, the portable box allows for multiple objects to be sanitized at the same time. The sanitizer in certain embodiments includes a plurality of UVC radiation sources mounted in the interior of the housing so as to surround the object to be sanitized on multiple sides.

Abstract: Dry adhesive materials, particularly in the form of a film or tape, for adhering one or more wet surfaces comprising: (i) one or more hydrophilic polymers; (ii) one or more amine coupling groups, and (iii) one or more cross linkers. The dry adhesive material, when placed in contact with the one or more wet surfaces, absorbs liquid from the one or more wet surfaces, swells to form temporary crosslinking with the wet surface, and forms covalent crosslinking with the one or more wet surfaces.

Abstract: Disclosed are methods of delivering an agent to the lumen of the vas deferens under guidance of ultrasound imaging. The methods include vas-occlusive contraception in which the vas deferens is non-surgically isolated and an occlusive substance is percutaneously administered into the lumen of the vas deferens under ultrasound. Also disclosed are methods of reversal of vas-occlusive contraception and methods of delivering an agent to the lumen of the vas deferens. Also disclosed are compositions for use in the methods of the invention.

Abstract: The invention relates to biomimetic, biodegradable composites including a magnesium (Mg) alloy mesh and a polymer/extracellular matrix (ECM). These hybrid composites, more particularly, are useful for the fabrication of medical implant devices, e.g., scaffolds, and are effective for bone regeneration. The fabrication process includes creating the Mg alloy mesh, and concurrently electrospinning the polymer and electrospraying the ECM onto the mesh.

Abstract: The invention relates to a scaffold material composition for forming a solid tissue scaffold, the composition comprising a plurality of hollow polymer pellets, each pellet comprising an open hollow extending through the pellet, and wherein the plurality of hollow polymer pellets are capable of interlinking and setting into a solid scaffold. The invention further relates to associated compositions, uses, method of treatment and kits associated with such material.

Abstract: Provided herein are inks including decellularized extracellular matrix (dECM) particles and scaffolds made from the inks. Also provided are methods of making the scaffolds and applications for the scaffolds. In an embodiment, a porous scaffold comprises dECM particles and an elastomer, wherein the scaffold is planar having a thickness of about 100 ?m or greater, the scaffold comprises irregularly shaped pores having a random orientation and distribution throughout the scaffold, and the scaffold is free of crosslinking between the molecular components of the scaffold.

Abstract: Embodiments of the present invention provide a method of treating a stricture in a nonvascular body lumen such as urethral strictures, benign prostatic hyperplasia (BPH) strictures, ureteral strictures, esophageal strictures, sinus strictures, and biliary tract strictures. Embodiments of the present invention provide a method for treating at least one of benign prostatic hyperplasia (BPH), prostate cancer, asthma, and chronic obstructive pulmonary disease (COPD). The method can include delivering, for example, via drug coated balloon catheters, anti-inflammatory and anti-proliferative drugs (e.g., rapamycin, paclitaxel, and their analogues) and one or more additives.

Abstract: A biocompatible electrical connection includes a substrate; a ferrule having a concentric flange at a first end of the ferrule; a first adhesive; and a second adhesive. The first adhesive adheres a first surface of the concentric flange of the ferrule to a surface of the substrate. The second adhesive fills an annular space between a hole in the substrate and the ferrule. The first adhesive or the second adhesive forms a conductive path on the surface of the substrate between the ferrule and a circuit pattern on the substrate.

Abstract: The present invention provides materials and methods for forming an interface between an appliance and living tissue using a foamed elastomeric material which contacts the tissue or similar surfaces. The elastomeric material is in the form of a durable and washable material that when applied to living tissue or similar surfaces displaces and flows in to non-conforming areas creating an air and/or water tight seal that substantially returns to an original shape when removed from the contact surface. The appliance may also include structural elements designed to optimize comfort, compliance and seal achieved through minimizing the pressure variation along the contact surface of the therapy device.

Abstract: In some aspects, the present invention provides surgical procedures that comprise applying compositions into and/or onto tissue, including supporting tissues (e.g., ligaments, connective tissue, muscles, etc.) for pelvic organs, among other tissues. In other aspects, the present disclosure pertains to compositions that are useful for performing such procedures. In still other aspects, the present disclosure pertains to kits that are useful for performing such procedures.

Abstract: A human-activity-environment air-purifying apparatus is provided that draws in airflow from an ambient environment, kills germs in the airflow within the apparatus and expels purified airflow back into the environment. The apparatus has a housing with an interior chamber. An airflow enters the chamber through an inlet. From the interior chamber, the airflow is expelled through an outlet. The apparatus has a germ-killing-system that kills germs in the airflow and has an airflow-generator which causes the airflow to flow from the inlet to the outlet. In one aspect, the apparatus has a three-dimensional filter structure that has air-filter-surfaces that define a filter interior region and encompassed by the air-filter-surfaces of the filter structure. The filter is positioned in connection with the inlet so that airflow entering the inlet is dispersed into the housing interior chamber in multiple directions exclusively through the air-filter-surfaces of the three-dimensional filter structure.

Abstract: A breastpump for expressing human breastmilk includes a multipart hygiene module having a first part with a flow opening for connecting to a interior, a valve body with at least one valve and a second part with a rigid cup for forming a pump chamber. The valve body is arranged between the first and second part and the hygiene module as a whole is connectable to the housing of the breastpump in a sealing and detachable manner.

Abstract: A portable hemodialysis system is provided including a dialyzer, a closed loop blood flow path which transports blood from a patient through the dialyzer and back to the patient, and a closed loop dialysate flow path which transports dialysate through the dialyzer. Preferably, the hemodialysis system includes a sorbent filter in the dialysate flow path. Furthermore, the hemodialysis machine includes a blood pump, and a pair of dialysate pumps. A processor controls the flow of blood through the blood flow path, and the processor controls the flow of dialysate through the dialysate flow path. In addition, the processor stores a patient treatment plan wherein the flow rate of the dialysate through the dialysate flow path reduces throughout the patient's treatment to maximize the amount of urea removed by the sorbent filter.

Abstract: A degassing module that may be used in conjunction with a sorbent regeneration cartridge is described. The degassing module may include an air inlet port, a fluid outlet port, a gas outlet port, first and second channels located in an interior chamber, a port connecting the first and second channels, and a hydrophobic membrane positioned above the second channel. The first channel may be in fluid communication with the air inlet port and the second channel may be in communication with the fluid outlet port. In some embodiments, each of the first and second channels may have a spiral configuration.

Abstract: Systems, methods, and devices are provided for the treatment of edema. In one aspect a method for implanting an indwelling catheter within a vein of a patient is provided. The catheter can extend from a position upstream of at least one outflow port of a duct of the lymph system to a terminal position downstream of the at least one outflow port. In use, a first restriction can be created within the vein proximal to a distal region of the catheter. The first restriction can define a localized low pressure zone distal of the restriction and within a portion of the vein housing the catheter. The low pressure zone can be adjacent to the at least one outflow port to enable fluid to pass from the at least one lymph duct outflow port into the vein.

Abstract: Provided herein are bedside systems and methods for performing customized cell-based therapies and treatments in a patient-connected, closed-loop continuous-flow manner, including cellular modifications and treatments, e.g., to produce chimeric antigen receptor-T (CAR-T) cells among other cellular modifications and treatments.

Abstract: The purpose of the present invention is to adsorb calciprotein particles. An adsorbent for calciprotein particles of the present invention is characterized in that the surface of a water-insoluble carrier is covalently bonded, through a hydrocarbon group, to at least one selected from the group consisting of amino group, carboxyl group, phosphate group, phosphono group, phosphino group, and thiol group.

Abstract: The present disclosure relates to various aspects of a procedure for reducing the carbon dioxide content in blood during the treatment of patients. A first aspect of the present disclosure relates to a buffer solution for use in reducing the carbon dioxide content in the blood when treating a patient suffering from pulmonary insufficiency or the complete failure of lung function, wherein the fluid is in gas exchange with a portion of the patient's blood conducted through an extracorporeal circuit. The first aspect of the present disclosure further relates to an apparatus for the extracorporeal reduction of the carbon dioxide content in the blood using said buffer solution. A second aspect of the present disclosure relates to a system for extracorporeal blood treatment, likewise using said buffer solution and the apparatus, and furthermore to a treatment apparatus for extracorporeal blood treatment comprising the aforementioned system.

Abstract: An aspiration and irrigation ultraportable device is disclosed. The device is configured to aspirate and irrigate alone or sequentially. The device comprises a digitally adjustable dry/wet vacuum and a spray/irrigator assembly that is powered by rechargeable batteries. The device has at least one easily disposable and cleanable aspirant/irrigant reservoir. The present invention relates to the field of medicine specially related to outpatient and in-home settings of aspiration and irrigation of nose, ear, open wounds, and other body fluids.

Abstract: Systems and methods for cleaning a colon or other portion of an intestine include optional use of sensors to detect conditions of blockage of flow of materials within an evacuation channel used to remove fecal material from the body; and devices and methods for purging such blockages from the evacuation channel.

Abstract: A dispersion device includes a first dispersion generating system, a second dispersion generating system and an outlet end element including a first outlet corresponding to the first dispersion generating system and a second outlet corresponding to the second dispersion generating system.

Abstract: A trocar assembly includes a trocar including an elongated tubular member extending between a distal end configured to be inserted into a surgical site and a proximal portion including a trocar housing configured for introduction of surgical instruments into the tubular member, wherein the trocar housing includes at least one latch receptacle. The assembly includes a cap, wherein the housing of the cap is attached to the proximal portion of a trocar. The cap includes a housing configured to be removably attached to a proximal portion of a trocar. The housing includes a flow passage therethrough from a distal end of the housing to a proximal opening of the housing. A filter medium is included within the housing spanning the flow passage for filtration of flow through the flow passage.

Abstract: The methods described herein provide improvements to the measurement of dose content uniformity of inhaler and nasal devices. The methods involve analyzing and measuring a spray pattern of an emitted spray from an inhaler or nasal device. The spray pattern may be used to determine the dose content uniformity of an inhaler or nasal device.

Abstract: Devices for generating and releasing vapor. In particular, described herein are portable devices for generating a low-temperature inhalable vapor having an elongated tubular body containing a vaporization chamber and a battery-powered heater, a removable mouthpiece covering the vaporization chamber, a display configured to indicate the temperature of the vaporization chamber; a microcontroller configured to regulate the temperature of the vaporization chamber, and a control to select from among a variety of temperature settings.

Abstract: A cartridge of an electronic vaping device includes a housing extending in a longitudinal direction. The housing includes a sidewall, a transverse wall at the first end of the sidewall, and an inner tube integrally formed with the housing. The sidewall is generally cylindrical and a first end and a second end. The transverse wall includes at least one outlet therein. The inner tube extends in the longitudinal direction. The inner tube is concentrically positioned with respect to the sidewall. The inner tube communicates with the at least one outlet. The cartridge also includes a reservoir between the sidewall and the inner tube. The reservoir is configured to contain a pre-vapor formulation.

Abstract: Sensing airflow and delivering therapeutic gas to a patient. At least some of the example embodiments are methods including: titrating a patient with therapeutic gas during a period of time when a flow state of breathing orifices is in a first state, the titrating results in a prescription titration volume; and then delivering the prescription titration volume of therapeutic gas to the patient when the flow state of the breathing orifices is in a second state different than the first state, the delivering only to the breathing orifices open to flow.

Abstract: An air-blowing device 10A includes an air blower 50 and a housing 20 that includes an intake hole 41a into which a fluid flows as a result of the air blower 50 being driven and an exhaust portion from which the fluid is discharged as a result of the air blower 50 being driven and that accommodates the air blower 50. The housing 20 is capable of expanding and contracting so as to change the internal volume of the housing 20.

Abstract: A respiratory monitoring system includes (10) a mechanical ventilator (12) configurable to perform a ventilation mode in that includes an inhalation gas delivery phase and provides extrinsic positive end-expiratory pressure (PEEP) at a PEEP level during an exhalation phase. A breathing tubing circuit (26) includes: a patient port (28), a gas inlet line (16) connected to supply gas from the mechanical ventilator to the patient port, a gas flow meter (30) connected to measure gas flow into lungs of the patient, and a pressure sensor (32) connected to measure gas pressure at the patient port. At least one processor (38) is programmed to: compute a proxy pressure comprising an integral of gas flow into the lungs measured by the gas flow meter; and trigger the inhalation gas delivery phase of the ventilation mode when the proxy pressure decreases below a trigger pressure threshold.

Abstract: A method for controlling oxygen mix for a single-limb non-invasive ventilator comprising a pressure controller, and both a blower and a pressurized oxygen source downstream of the blower, each comprising a controller and a flow valve controlling flow, comprising: (i) generating a flow trajectory; (ii) providing the generated flow trajectory to a pair of complimentary flow coupling filters comprising a blower flow coupling filter and an oxygen flow coupling filter; (iii) generating an output from each of the filters, comprising an input flow trajectory for the blower flow controller and an input flow trajectory for the oxygen flow controller; and (iv) adjusting, by the blower flow controller and/or oxygen flow controller based on the input flow trajectory, target pressure, and oxygen mix, the blower speed controller and/or the pressurized oxygen source proportional flow valve.

Abstract: A medical system for assisting with an intubation procedure for a patient. The system comprising airflow sensors configured to obtain data indicative of airflow in the patient's airway and physiological sensors configured to obtain information regarding airflow in the patient's lungs. The system further including a monitoring device communicatively coupled to the airflow sensors and the physiological sensors. The patient monitoring device comprising at least one processor coupled to memory and configured to: provide a user interface on a display and assist the rescuer in determining proper placement of an endotracheal tube, receive the data indicative of the airflow in the patient's airway, receive the physiological information regarding the airflow in the patient's lungs, and determine whether the tube is properly placed based on the received physiological information, and present an output of the determination of whether the ET tube was properly placed.

Abstract: An ambulatory assist ventilation (AAV) apparatus and system are disclosed for the delivery of a respiratory gas to assist the spontaneous breathing effort of a patient with a breathing disorder. The AAV system includes a compressed respiratory gas source, a respiratory assist device for controlling respiratory gas flow to the patient, a patient circuit tubing and a low profile nasal interface device, which does not have a dead space or hollow area where CO2 can collect, for delivering the respiratory gas to the patient, wherein the nasal interface device is fluidly connected to the respiratory assist device via tubing for receiving the respiratory gas therefrom. In some cases, the nasal interface device may be used in combination with other gas sources, such as oxygen concentrators, to provide dual therapy capability suitable for some applications.

Abstract: The invention relates to a respiratory system comprising a first patient interface for delivery of a first flow of gases to a patient, a second patient interface for delivery of a second flow of gases to the patient, and a device and/or sensing arrangement that is configure to facilitate a switching of the system between a first respiratory mode where the device allowing delivery of the first flow of gases to an outlet of the first patient interface when the second patient interface is absent from the patient, and a second respiratory mode where the device reducing or stopping delivery of the first flow of gases to the outlet of the first patient interface when the second patient interface is located together with the first patient interface upon the patient.

Abstract: An additive gas delivery apparatus for delivery of additive gas to inspirational gas can be set to deliver the additive gas according to a dosing setting in normal therapy, and can be set to deliver according to a backup dosing setting in response disruption of signals representing data for controlling the delivery of additive gas according to the dosing setting in normal therapy. An additive gas delivery apparatus has an inlet for the additive gas and an integrated inlet for gas for oxygenating the patient that are connected to a backup line to mix the additive gas and gas for oxygenating the patient to a set concentration of additive gas in the gas mixture at an integrated backup outlet of the additive gas delivery apparatus.

Abstract: A respiratory assistance apparatus includes a flow generator and a humidifier. The humidifier includes a humidification chamber. The humidification chamber comprises a water tub that is configured to receive a volume of water. A lid is hingedly coupled to the water tub for enclosing a volume contained within the water tub.

Abstract: A therapeutic cognitive focus device for improving the cognitive focus of a user in a learning environment by providing a variety of tactile sensations for the user is described. The device includes a strap having ends adaptable to form a bracelet or the like, and having various focus elements attached to or formed on the strap for a user to engage in hyperactive movements to increase cognitive focus. A first focus element comprising at least one rotatable bead, a second focus element comprising a plurality of fabric paint patterns, and a third focus element comprising at least one adjustable string having various shaped weighted ends, each providing a variety of tactile sensations when engaged by the user. The tactile sensations provided to the user when operating the device contribute to increasing cognitive focus when used in a learning environment.

Abstract: Methods and systems for pre-action training are described. In an aspect, a method is presented for constructing a user-controllable image comprising obtain anatomical and physiological data associated with a body, storing the anatomical and physiological data in a database; and creating the user-controllable image based on the stored anatomical and physiological data. At least a moveable portion of the user-controllable image may be constructed to move based on input from a user. Victims of stroke, TBI, or other neurological setbacks may pre-train their nervous system for use of one or more injured body parts. The methods and systems described provide pre-action training control of non-virtual prostheses, exoskeleton body parts, powered orthotic devices, robots or other motile or audiovisual output devices used to improve therapy, rehabilitation, and in some circumstances to lessen or prevent blood clots. Therapy may be remotely delivered.

Abstract: A method for applying adapted colour rendering in relation to intensity of light of wavelengths relevant to the circadian rhythm of a user, a computer program, a carrier, a system and a head-mounted device is disclosed. The method comprises receiving gaze tracking information identifying a gaze vector of the user of the system, and determining a respective location of a first area of the display and a second areas of the display based on the identified gaze vector. A first colour rendering mode is applied in the first area of the display, and a second colour rendering mode is applied in the second area of the display. The first colour rendering mode and the second colour rendering mode differ in relation to a degree of selective adaptation of intensity of light of wavelengths relevant to the circadian rhythm of the user.