Abstract: A patient interface comprises an opening for receiving a flow of gas from a conduit and an adaptable connector system for connecting at least two different types of conduit with the opening. The adaptable connector is permanently mounted with the patient interface so it cannot be lost and is able to swing into alignment with the opening, thereby providing a different connection end to be compatible with a second or further type of conduit connection end.

Abstract: A device for capturing momentarily an exhaled breath of a COVID 19 patient containing active SARS-CoV-2 virions within an accessible compartment of said device and converting said active SARS-CoV-2 virions into far-UVC inactivated SARS-CoV-2 virions by exposure to an activated 222 nm far-UVC lamp mounted in said accessible compartment and with the next inhaled breath of said COVID 19 patient said far-UVC inactivated SARS-CoV-2 virions are positioned within the respiratory system ready to be captured by an antigen-presenting cells such as the Dendritic cells (DCs) which are antigen-presenting cells that capture, process, and present antigens to lymphocytes to initiate and regulate the adaptive immune response. Said far-UVC inactivated SARS-CoV-2 virions can be collected from said accessible compartment of said device and processed into viable vaccine that can be administered to front-line workers.

Abstract: An active humidifier includes a disposable cartridge provided with a humidification chamber adapted to contain water to be heated for air humidification, with an inlet mouth for air introduced by a ventilation device and with an outlet mouth for conditioned air to a patient, the cartridge includes a disposable heating element directly inserted inside the humidification chamber close to the bottom and distanced therefrom, immersed in the water and lapped on all sides, the cartridge also includes an electrical connector for the electrical connection of the disposable heating element, and the disposable heating element includes an electrical resistor and in the humidification chamber is a sealed casing entirely made of plastic material.

Abstract: This disclosure describes systems and methods for humidifying ventilator delivered breathing gases. These systems and methods utilize a hollow cone atomizer (e.g., a pressure swirl atomizer) and/or a heating element associated with a heating circuit and/or a heating tube. In some aspect, the systems and methods utilize received flow, temperature, and/or humidity information to determine an amount of water to add to breathing gases to reach a desired humidity of the breathing gases delivered to the patient. In further aspects, the humidification system can serve as a nebulization system for delivering nebulized medicine.

Abstract: A method for detecting the tendency of a passenger of a vehicle to get motion sickness by using a rod and frame test is disclosed. An image designed to carry out a rod and frame test is displayed in the vehicle. The rod and the frame each enclose an angle greater than 0 degrees and less than 90 degrees with a horizontal spatial axis and/or a vertical spatial axis. A request is issued to correct the rod into a vertical or horizontal position by means of an input device. An input carried out by the passenger to correct the rod is recorded. The rod and frame test is evaluated by an evaluation device based on the recorded input of the passenger, and at least one measure is issued to prevent and/or combat the occurrence of motion sickness, depending on the result of the evaluation.

Abstract: Distributed feedback-circuitry uses operant conditioning to train a subject to achieve a target state of consciousness. The distributed feedback-circuitry includes remote circuitry having both a feature-extraction circuit and a controller. The former receives a real-time electroencephalogram and information indicative of a target state from the subject and generates a measured feature-set and a target feature-set therefrom. The latter causes transmission of a conditioning stimulus to be listened to by the subject. The conditioning stimulus causes the measured feature-set to be driven towards the target feature-set. The controller also causes the conditioning stimulus to comprise a conditioning-audio stimulus that transitions between being a base-audio stimulus with no reward stimulus and being a base-audio stimulus that has been operated on to incorporate a reward stimulus. The controller causes this transition based on progress made in causing the measured feature-set to conform to the target feature-set.

Abstract: A balloon guide catheter having a sleeved inflation lumen secured with a wire wrap for improved inflation lumen kink protection and a welded balloon construction provides a robust and flexible catheter with an exceptionally large inner lumen relative to its outer profile and enables rapid and reliable balloon inflation and deflation in a highly deliverable and kink resistant catheter. Balloon guide catheters having multiple sleeved inflation lumens and proximal luers for utilizing the multiple inflation lumens are also provided.

Abstract: A lead delivery apparatus and a method of delivering a medical lead to an anatomic target site. The method includes inserting a hydraulic plug into an internal delivery lumen of a delivery shaft, and coupling a medical lead to the hydraulic plug. Hydraulic pressure is applied to the hydraulic plug through the delivery lumen, thereby moving the hydraulic plug toward an anatomic target site, and advancing the medical lead toward the target site.

Abstract: An intermittent urinary catheterisation aid 2 and an assembly is provided. The aid allows a user to manipulate an intermittent urinary catheter 3 in one direction and insert it into the urethra in another direction.

Abstract: Disclosed herein are embodiments of stabilizers for use in delivering a replacement heart valve. The stabilizers can receive a portion of a delivery system, such as a handle, to prevent unwanted motion of the delivery system. The stabilizer can include a linear actuator for adjusting a position of the delivery system once held within the stabilizer.

Abstract: A medical device is provided that can be held and operated with a single hand to cause a catheter to be placed at a selected location in a patient's body. The user's other hand is free to perform other tasks, such as operating an ultrasound probe, for example. The medical device may also include a valve that can be operated with the same hand that holds the medical device to open a port to cause a fluid, such as a nerve block agent, for example, to be injected into the patient's body at the selected location.

Abstract: A medical device has a distal member with a configuration that can be changed by means of a control handle with a control assembly employing a rotational cam, a shaft, and a pulley, where the rotational cam is rotationally mounted on a portion of the control handle for rotation by a user. The rotational cam operates on the shaft to move it proximally or distally depending on the direction of rotation which in turn rotates the pulley to draw or release a puller wire to change the configuration of the distal member of the medical device. The shaft is oriented along a diameter of the control handle. The shaft has two ends which extends through two axial guide slots in the portion of the control handle to sit two opposing helical tracks formed on inner surface of the rotational cam. The guide slots are parallel with the longitudinal axis of the control handle and therefore maintain the shaft's diametrical orientation as the rotational cam is rotated to move the shaft proximally or distally.

Abstract: A catheter configured to dynamically compensate for the impact of internal and external forces that act upon the catheter during use is disclosed. The catheter may include sensors configured to measure received forces on control cables that extend within the catheter. A controller, coupled to the sensors, may record received force measurements associated with a working position of a distal end of the catheter. The controller may monitor subsequently received forces to identify force variances that may deflect the distal end of the catheter from its working position and may apply a driving force to one or more of the control cables to minimize the force variances. Monitoring received forces during use and applying compensating drive forces may reduce deflection of the distal end of the catheter, increasing the accuracy and precision of an annuloplasty procedure while minimizing potential damage to cardiac tissue.

Abstract: The present invention provides a steerable medical or surgical device, in particular a steerable catheter having one or more actuators which may be integrated into a catheter without the need for welding the actuator to the catheter, the device comprising a main shaft having a proximal end and a distal end, and at least one braided actuator coupled to the main shaft at or adjacent the distal end.

Abstract: A catheter includes a handle and an elongate member extending from the handle. The catheter may also include steering system coupled to the handle. The steering system may be configured to deflect at least a portion of the elongate member in at least one direction. The catheter may also include a locking mechanism configured to lock the portion of the elongate member in a deflected configuration, and a lever coupled to the handle. The lever may be configured to move from a first position to a second position to engage the locking mechanism. The lever may also be configured to be separably retained at least at one of the first position or the second position to prevent movement therebetween.

Abstract: A delivery device for delivering an instrument into a catheter assembly may include a syringe, which may include a barrel and a plunger movable within the barrel. The plunger may include a handle and a stopper coupled to a distal end of the handle. The stopper may include a channel. The delivery device may include a guidewire disposed within the barrel and extending through the channel. In response to depression of the plunger, the guidewire may move through the channel and a first end of the guidewire may be advanced in the distal direction. A second end of the guidewire may be fixed.

Abstract: A valve actuator that moves in a catheter assembly between a first position where a valve is closed and a second position where the valve is open, the valve actuator including a shaft portion at a distal end of the valve actuator that is configured to pierce the valve, a mating portion at a proximal end of the valve actuator that is configured to engage a Luer device, a diameter reduction region that connects the shaft portion and the mating portion, and a plurality of windows that extend through the valve actuator for flushing fluid, the plurality of windows being disposed in the diameter reduction region, wherein each of the plurality of windows does not extend a full length of the diameter reduction region.

Abstract: A safety intravenous catheter that includes a passive release feature. The catheter assembly includes ready, safe, and released positions. In the release position, a retainer being in a proximal retainer position relative to a collar enables release of the catheter hub from the catheter insertion device. The sharp tip of the insertion needle remains inaccessible in the release position in order to prevent unwanted needle sticks.

Abstract: A medical insertion device includes an introducer assembly, a needle, and a housing. The introducer assembly includes a dilator coaxially disposed in a sheath, the dilator removably engaged to the sheath in an insertion configuration. The needle is coaxially disposed in the dilator, the needle having a distal tip and a proximal end coupled to a needle hub. The housing may be removably engaged to the dilator. The needle hub is movably disposed in the housing between a first locked position, a second locked position, and a third locked position.

Abstract: A guide wire includes a core shaft, a coil body curved from the proximal end side to the distal end side of the guide wire, and a fixing portion fixing the core shaft to the coil body. The core shaft includes a first contact part in contact with an inner surface of the coil body on an opposite side to the curving direction, and a second contact part in contact with the inner surface of the coil body in the curving direction, at a position closer to the distal end than the first contact part. The fixing portion includes a first fixing portion fixing the core shaft to the coil body at a position closer to the proximal end than the first contact part, and a second fixing portion fixing the core shaft to the coil body at a position closer to the distal end than the second contact part.

Abstract: Disclosed are a drug-coated balloon and a method for preparing the same. The drug-coated balloon comprises a surface liquefied drug coating and a balloon, wherein the drug coating comprises a lipophilic excipient and a drug. The balloon can reduce the loss of the drug during delivery and increase efficiency in transferring the drug to a lesion site.

Abstract: An allergen-loadable microneedle cartridge is disclosed. The cartridge includes at least one substrate, a plurality of microneedles in a microneedle layout protruding from at least one substrate, and fillable allergen sites corresponding to the microneedle layout. The fillable allergen sites and microneedle layout are configured such that the microneedles can penetrate subject skin and deliver pharmacologically active doses of allergens in a minimally invasive process. A planar allergen filling system for loading the allergen-loadable microneedle cartridges is also disclosed. The system has a loading section with spaced-apart allergen loading sites that correspond to the microneedle layout of the microneedle cartridge. Filling wells having allergen deposition areas larger than the allergen loading sites transfer deposited allergen to the allergen loading sites through capillary channels.

Abstract: A therapeutic delivery device that provides a controlled release of high doses of a therapeutic agent in a local area, sustains the high dose controlled release with a percutaneous port for refilling the device, and is versatile for use with multiple types of therapeutic agents and/or implant systems. A rate determining/controlled release membrane is used to decrease the molecular mobility of the therapeutic compounds thereby controlling the therapeutic release profile. The therapeutic delivery device includes a body defining an internal reservoir for receiving a therapeutic agent and including a first membrane for providing a controlled release of the therapeutic agent to the surgical site, a port in fluid communication with the reservoir, a sleeve configured to encapsulate the body, and a rigid housing configured to support the body and a portion of the sleeve, the rigid housing configured to release the body and the sleeve after the body and the sleeve are anchored position relative to the surgical site.

Abstract: Some embodiments disclosed herein relate to a medical connector having a backflow resistance module configured to prevent fluid from being drawn into the connector when a backflow inducing event occurs. In some embodiments, the backflow resistance module can include a variable-volume chamber configured to change in volume in response to a backflow-inducing event and a check valve configured to resist backflow. In some embodiments, the medical connector can include a fluid diverter configured to direct fluid flowing through the medical connector into the variable volume chamber to prevent fluid stagnation therein. In some embodiments, the medical connector includes a body member, a base member, a seal member, a support member, and a valve member.

Abstract: The present disclosure proposes a pen-like assembly of caps for cleaning and protecting needle-free iv-connectors, with an extended shelf life. An enhanced gas-tightness in sealing is arranged in-between successively arranged caps that are engaged together. A first approach is based on enhancing geometric compliance between striking surfaces, by contacting one or more material components that have different respective Shore hardness values. A second approach is based on meandering and extending a possible fluid communication route from a cavity inside a cap towards surroundings of the assembly. A third approach includes the provision of the fluid communication route with an adhesive or sealant to achieve a gas-tight sealing. A fourth approach includes circumferentially covering junctions with one or more covers that are substantially gas impermeable.

Abstract: A connector for a fluid drainage system having a body defining a drainage lumen extending longitudinally from a distal portion to a proximal portion. The body can include a piston housing and an inlet in fluid communication with a positive air pressure source. A piston is slidably engaged with the piston housing along a transverse axis between a first position and a second position. In the first position, the piston provides fluid communication between the distal portion and the proximal portion of the drainage lumen and occludes fluid communication between the inlet and the drainage lumen. The piston in the second position occludes fluid communication between the distal portion and the proximal portion of the drainage lumen and provides fluid communication between the inlet and the drainage lumen to clear dependent loops, while preventing distal fluid flow into a catheter.

Abstract: This nest comprises a plurality of breakable connecting bridges, a plurality of flanges arranged in a predetermined pattern and configured to form the flanges of the medical containers, the flanges being connected to the breakable connecting bridges, and a supporting structure attached to the breakable connecting bridges so as to support the flanges. The flanges are integrally formed with the breakable connecting bridges and the supporting structure.

Abstract: Drip chambers, burettes and other IV set components are described herein. An IV set component described herein comprises a chamber body, an inlet portion, and a disk valve. The chamber body defines a chamber volume and an outlet. The chamber volume is in fluid communication with the outlet. The inlet portion is coupled to the chamber body, the inlet portion defining an inlet, a priming port, a drip port. The inlet is in fluid communication with the priming port and the drip port, and the priming port and the drip port are each in fluid communication with the chamber volume. The disk valve is coupled to the inlet portion. The disk valve is movable to direct flow from the inlet to the priming port in a first position and to direct flow from the inlet to the drip port in a second position.

Abstract: A bolus delivery device is provided that comprises a housing and a reservoir defined by an activation dome and a reservoir seat and disposed within the housing for receipt of a volume of a fluid. The bolus delivery device further comprises a bladder disposed in the housing that is in fluid communication with the reservoir for receipt of the fluid from the reservoir; an actuator; an inlet conduit in fluid communication with the reservoir for providing the fluid to the reservoir; and an outlet conduit in fluid communication with the bladder for providing the fluid to a patient. The actuator is in operative communication with the reservoir to initiate a flow of the fluid from the reservoir to the bladder. The bladder expands as the bladder receives the fluid and contracts as the bladder dispenses the fluid. An infusion assembly including a bolus delivery device also is provided.

Abstract: A medical system configured to aid a user in locating an access port of an implantable medical device, the medical system including an implantable port comprising a medicament chamber accessible through a septum, a localizer base operably coupled to the implantable port comprising an array of electromagnetic field emitting coils, an antenna array comprising a plurality of electromagnetic field sensing coils, and a user interface adapted to display data received from the antenna array to visually depict a relative position of the antenna array relative to the localizer base.

Abstract: The present disclosure describes a medical syringe pump and a method for calibrating a medical syringe pump. In some cases the medical syringe pump is configured and/or prepared to execute the method according to the present disclosure, or has been calibrated accordingly. This disclosure also describes a blood treatment apparatus which comprises such syringe pump or is connected to such syringe pump. Furthermore, the present disclosure describes a digital storage medium and/or a computer program product as a computer program.

Abstract: Some embodiments are directed to a medical device for fluidly connecting to a medical spike, including a spike port configured to receive therein the medical spike and establish fluid communication between the medical spike and the medical device The spike-locking mechanism can be configured to resist extraction of the medical spike from the spike port.

Abstract: There is provided a method and a system for determining recommended multiple daily injections (MDI) therapy values for administering to a given subject. Consumed meals, insulin basal doses administered and insulin bolus doses administered to the given subject are received. An initial meal ratio parameter and an initial basal insulin dose used by the given subject are received. A predicted glucose concentration parameter is determined based on the consumed meals, the insulin basal dose, the insulin bolus doses, and the initial meal ratio parameter. An actual glucose concentration parameter is received. A set of optimal MDI therapy parameters are estimated using the predicted glucose concentration parameter, and the actual glucose concentration parameter.

Abstract: One or more embodiments of the disclosure relate, generally, to a diabetes management system. The diabetes management system may include a computing device that is configured to receive data relating to prior insulin use of a user and calculate a sliding scale glucose correction based, at least in part, on the data relating to prior insulin use.

Abstract: A system and a method for filling an on-body injector includes a needle of the prefilled syringe being aligned with a fill port of the on-body injector. The needle may then be inserted into a guide of a needle cover attached to the on-body injector. An adapter attached to the syringe barrel may guide the needle into a center of the bore of the guide and into the fill port of the on-body injector. The needle may be inserted into the fill port and the adapter may be mechanically coupling to the guide. After the adapter is mechanically coupled to the guide, a volume of the drug of the prefilled syringe may be dispensed into a reservoir of the on-body injector. Once the reservoir is filled to a desired amount, the needle may be removed from the fill port by decoupling the adapter from the guide.

Abstract: A medical injection system adapted for a single-handed injection, the medical injection device comprising a gas compartment configured to contain a gas, the gas compartment comprising a piston, a reservoir intended to contain a drug composition, the reservoir having a proximal portion and a distal portion provided with a fluid exit configured to receive an injection needle, wherein the piston can move proximally between a distal position defining a first volume of the gas compartment to a proximal position defining a second volume of the gas compartment smaller than the first volume, and wherein the gas compartment is in gas communication with the reservoir in order to force the drug composition through the fluid exit, when the piston is moved proximally.

Abstract: A drug delivery device includes a compartment sized to receive a cartridge. The compartment includes a cartridge bay that opens so that a cartridge may be inserted into the cartridge bay and that closes when the cartridge is received by the compartment. The drug delivery device also includes a housing including an expanding assembly. The expanding assembly includes a driver supported from a distal end by a linear stabilizer that includes a bearing configured to push against the housing. The driver is rotated by a motor. The expanding assembly also includes two mid screws threadedly connected to the driver, a plunger driver threadedly connected to the two mid screws, and an anti-rotational guide that prevents rotation of the plunger driver.

Abstract: The present disclosure relates to medical delivery devices that include a barrel having an inner surface, and in at least one embodiment, the inner surface is hydrophilic. The medical delivery device may further include a stopper may having an elastomeric body, one or more fluoropolymer layers, and two or more ribs laminated to the one or more fluoropolymer layers. In some embodiments, the contact angle of the inner surface of the barrel is less than about 58°. Additionally, the stopper includes a sliding surface that is less than about 2.0 mm. The barrel provides inner surface that in combination with the fluoropolymer laminate or fluoropolymer film achieve high levels of air and liquid impermeability while also maintaining an acceptably low break loose force, low average glide force, and low glide force variation. In some embodiments, the compressibility stopper against the barrel is greater than about 7.9%.

Abstract: A kit is disclosed for accurately loading a small volume dose of a medication within a syringe and for delivering the small volume dose of the medication at a treatment site. The kit generally includes a loading and delivery system in accordance herewith, a syringe, and a medication. The loading and delivery system includes a syringe delivery ring and a syringe loading guide, which may be used for example, to administer a small volume dose of a medication at the end of an ocular surgery.

Abstract: A power injector system having a power injector for enabling delivery of fluid in an injection procedure to be performed on a patient may include one or more processors; a first user interface; and a second user interface. The first user interface and the second user interface may be configured to accept a plurality of user inputs associated with control of a plurality of operations of the power injector system and display information associated with the plurality of operations. One of the first user interface and the second user interface may be proximate to the power injector and the other may be remote from the power injector. The one or more processors may be programmed and/or configured to independently control the first user interface and the second user interface based on a first user input and a next user input received from the first user interface and/or the second user interface.

Abstract: The present invention provides a drug injection device (100, 100?, 100?) comprising a first element (130) and a second element (102, 102?, 102?) configured to undergo movement relative to each other corresponding to an action performed on or by the drug injection device (100, 100?, 100?), wherein the first element (130) comprises serially disposed protrusions (133), and wherein the second element (102, 102?, 102?) comprises a second element base and a deflectable transducer (170, 170?, 170?). The deflectable transducer (170, 170?, 170?) defines a base portion attached to the second element base, and a deflectable portion (162) configured for sequentially cooperating with the plurality of protrusions (133), wherein a processor (165) is electrically connected with the deflectable transducer (170, 170?, 170?) to register activation signals.

Abstract: The present disclosure relates to a dosage measurement system for a medicament delivery device. The medicament delivery device comprises a medicament reservoir, a lead screw and a drive sleeve. The drive sleeve is rotatable to axially displace the lead screw relative to the drive sleeve to dispense medicament from the medicament reservoir. The dosage measurement system comprises a sensor unit and a processor. The sensor unit is configured to measure rotation of at least one of the drive sleeve and lead screw. The processor is configured to determine a dosage dispensed from the medicament reservoir based on the measured rotation of said at least one of the drive sleeve and lead screw.

Abstract: A device for administering a fluid product includes a first housing part with a receiver for the product, a second housing part detachably connectable to the first housing part, a piston rod held such that it can be displaced for the exertion of an emptying movement, an actuatable or releasable drive element for the piston rod, a coupling element including a coupling input element that couples the drive element to the piston rod in a coupling engagement, transmits a driving force of the drive element to the piston rod, and triggers the emptying movement, and a decoupling element displaceably connected to the second housing part and coupled to the first housing part such that it is displaced, by a movement of the housing parts in relation to each other when the housing parts are separated into a decoupling position wherein the piston rod is decoupled from the coupling input element.

Abstract: A syringe mixing system is provided for housing and mixing contents between at least two syringes. In some embodiments, a syringe coupler is provided that receives first and second syringes and includes a valve member that is convertible between a closed position and an open position. Retention systems for preventing or inhibiting removal of at least one syringe after use are also provided.

Abstract: The disclosure relates to devices and methods for the treatment of edema which devices use an intravascular edema pump with an anticoagulant. The invention provides devices and methods for treating edema that use an indwelling catheter to place an impeller in a blood vessel of a patient, near an outlet of a lymphatic duct. Operating the impeller creates a local depression in blood pressure, which promotes drainage of lymph from the lymphatic system. The catheter is also used to release an anticoagulant such as heparin to wash and lubricate the impeller. Specifically, the anticoagulant inhibits clotting, hemolysis, or thrombosis from occurring and interfering with smooth operation of the impeller.

Abstract: A controller for an implantable blood pump, includes an accelerometer configured to measure at least one from the group consisting of position and movement of the controller. Processing circuitry is configured to control operation of the implantable blood pump, the processing circuitry being in communication with the accelerometer, the processing circuitry being configured to adjust a speed of the implantable blood pump if the measured at least one from the group consisting of position and movement deviates from a respective predetermined threshold.

Abstract: Disclosed are systems and techniques for determining an acoustic biomarker. For example, a precordial sound recording that includes at least a first sound component corresponding to a heart and a second sound component corresponding to a left ventricular assist device (LVAD) can be obtained. At least a portion of the second sound component corresponding to the LVAD can be filtered from the precordial sound recording to yield a filtered precordial sound recording. Based on the filtered precordial sound recording, at least one acoustic biomarker can be determined.

Abstract: An apparatus for a heart of a patient having a cardiac assist device adapted to be implanted into the patient to assist the heart with pumping blood. The apparatus has a sensor adapted to be implanted into the patient. The sensor in communication with the cardiac assist device and the heart which measures native volume of the heart. Alternatively, the sensor monitors the heart based on admittance while the cardiac assist device. Alternatively, the sensor monitors the heart based on impedance.

Abstract: The present disclosure is directed towards devices, methods, and related systems that are minutely-invasively delivered to the brain parenchyma, subdural or subarachnoid space where the devices, methods, and systems directly interface with central nervous system media (i.e., fluid or tissue) enabling detecting, sensing, measuring, stimulating, altering and/or modulating of the media or tissue surfaces.

Abstract: The invention relates to a surgical application tool (18) for implanting an electrode wire on nerves in an inner area of a pelvis of a human body, the surgical application tool (18) including a mandrel (16) having an engagement tip (19) and a shaft section (02) and including a sleeve (01) which is configured to insert and guide the electrode wire through a sleeve interior (08) when the mandrel (16) is removed, the sleeve (01) extending at least along the shaft section (02) and being detachable from the mandrel (16), a handle (20) being provided on the mandrel (16) and/or the sleeve (01) for the extracorporeal handling of the application tool (18), and the handle (20) being configured to manually rotate and/or pivot the mandrel (16) and/or the sleeve (01) when it is inserted into the body.