Abstract: An occlusion device for the left atrial appendage is plastically deformable and biodegradable.

Abstract: A method of preparing a ventricular partitioning device for implantation using a delivery system can include coupling the ventricular partitioning device to a delivery catheter, loading the ventricular partitioning device and a portion of the delivery catheter into a sleeve and creating a liquid-tight seal between a portion of the sleeve and the delivery catheter, coupling a distal end of the sleeve to a guide catheter, and delivering fluid through at least one of the first fluid delivery port or the second fluid delivery port. The method can be performed with the delivery catheter or the sleeve having a first fluid delivery port positioned thereon. The method can be with the guide catheter having a second fluid delivery port positioned thereon.

Abstract: An occlusion device includes a braided mesh body and at least one pinch member. The braided mesh body comprises plural strands each having a first end portion and a second end portion. The plural strands fold over to bring the second end portions of the plural strands adjacent to the first end portions of the plural strands forming a double-layer of the braided mesh body. In an example occlusion device, at least one of the plural strands is radiopaque, and the at least one pinch member is non-radiopaque.

Abstract: A surgical clip applier includes an elongated portion, a drive shaft, and an end effector. The drive shaft extends at least partially through the elongated portion. The end effector is disposed adjacent a distal end of the elongated portion, and includes a collar and a distal housing. The collar is coupled to the drive shaft and is movable relative to the distal housing. The collar is configured to support a base of a two-part fastener. The distal housing includes a leg and a C-shaped portion extending from a distal end of the leg. The C-shaped portion is configured to support a clip of the two-part fastener.

Abstract: Embodiments of the present invention are directed to devices, systems and methods adapted for implementing intermittent displacement of blood to mitigate peripheral nerve neuropathy such as that induced by chemotherapeutic agents (i.e., chemotherapy-induced neuropathy (CIN)) that are administered to a patient. Such devices, systems and methods advantageously provide for precise, uniform and controlled blood flow occluding (and optionally blood displacing) compression along irregular surfaces of an appendage of a patient. Such precise, uniform and controlled blood occluding compression is imparted upon the epidermal and dermis skin layers within the aforementioned areas of a patient's extremities to decrease the time that free nerve endings located in the epidermal and encapsulated nerve endings located in the dermis skin layers are exposed to nerve damaging chemotherapy chemicals, thereby substantially decreasing CIN caused by prolonged exposure to such chemicals.

Abstract: Embodiments of the present invention are directed to devices, systems and methods adapted for implementing intermittent displacement of blood to mitigate peripheral nerve neuropathy such as that induced by chemotherapeutic agents (i.e., chemotherapy-induced neuropathy (CIN)) that are administered to a patient. Such devices, systems and methods advantageously provide for precise, uniform and controlled blood flow occluding (and optionally blood displacing) compression along irregular surfaces of an appendage of a patient. Such precise, uniform and controlled blood occluding compression is imparted upon the epidermal and dermis skin layers within the aforementioned areas of a patient's extremities to decrease the time that free nerve endings located in the epidermal and encapsulated nerve endings located in the dermis skin layers are exposed to nerve damaging chemotherapy chemicals, thereby substantially decreasing CIN caused by prolonged exposure to such chemicals.

Abstract: A surgical saw system including a saw, a blade cartridge and an attachment. The saw including a housing and a reciprocating shaft. The blade cartridge that may be removably coupled to the saw includes a bar and a rack. The bar includes a first holding feature. The rack is moveably disposed within the bar and is configured to removably couple to the reciprocating shaft of the saw. The attachment is disposed between and connecting the bar of the blade cartridge to the saw. The attachment may include a coupling feature in selective releasable engagement with the first holding feature of the bar to hold the bar static relative to the saw. The blade cartridge may also include a drive link that extends from reciprocating shaft of the saw and the rack for imparting the reciprocal motion of the reciprocating shaft to the rack.

Abstract: The present invention relates generally to methods and systems for an adjustable drill stop, which has additional optional features of tissue retraction, visualization via transparent or semi-transparent material and/or window(s) on its size, precise gradation of depth by rotation indicated on side of the device, windows on the side for irrigation while drilling, and ability to utilize this device in setting of surgical drilling, in a drill which cannot be easily “overpowered” by typically applied forces (e.g. downward pressure by typical user).

Abstract: Bone marrow aspirate harvesting is provided via use of a surgical device that includes a needle including a plurality of lateral holes defined at different positions longitudinally along a wall thereof and a movable aspiration insert within the needle, wherein the needle need not be repositioned within the patient to harvest bone marrow aspirate. The surgical device includes a needle with lateral holes; a movable aspiration insert including an aspiration window that is sized to interface with one lateral hole of the plurality of lateral holes at a time, wherein the aspiration insert is disposed in a lumen of the needle; and a handle including a positioning means in communication with the aspiration insert, wherein the positing means is configured to actuate between a first state and a second state to move the aspiration insert a certain distance in a first direction along a longitudinal axis of the needle.

Abstract: A method of implant a knee prosthesis includes forming a bone void at an end of a bone, implanting a void filler in the bone void, and implanting a knee prosthesis onto the end of the bone so that a stem of the knee prosthesis is received by the void filler.

Abstract: Systems and methods for joint replacement are provided. The systems and methods can include a surgical orientation device and/or a reference sensor device. The surgical orientation device and orthopedic fixtures can be used to locate the orientation of an axis in the body, to adjust an orientation of a cutting plane or planes along a bony surface, to distract a joint, to measure an angle, to orient a cutting guide, to orient a resection guide, to resect the femur, or to otherwise assist in an orthopedic procedure or procedures.

Abstract: A balloon catheter includes a tubular body and a balloon circumferentially around a portion of the tubular body. The tubular body includes an outer surface and an inner surface defining a lumen of the tubular body. The balloon comprises a proximal end portion and a distal end portion each being secured to the tubular body, and a distensible portion defining an interior that is in fluid communication with the lumen of the tubular body. The distal end portion of the balloon extends through the outer surface and the inner surface into the lumen of the tubular body, forming a sealing portion circumferentially around the inner surface of the tubular body. A catheter assembly including a balloon catheter and a method of use are also provided.

Abstract: Systems, devices and methods for removing a blood clot (10) from a blood vessel (12). Various uses of suction pressure and positive pressure, proximal and/or distal to the blood clot (10) assist with clot dislodgement and removal. The pressure(s) may be constant and/or cycled/pulsed to assist with clot dislodgement and/or removal. Various further devices assist with separating the clot (10) from the vessel (12).

Abstract: Apparatuses, capacitor arrays, and methods for generating therapeutic compressed acoustic waves (e.g., shock waves). In the apparatuses and at least some of the methods, a plurality of electrodes can disposed in a chamber that is defined by a housing and configured to be filled with liquid, and a plurality of capacitors can be electrically connected to the electrodes and can be carried by (e.g., physically coupled to) the housing. Voltage pulses can be applied simultaneously to the plurality of electrodes (e.g., to begin to vaporize and ionize portions of the liquid to provide at least one inter-electrode conductive path between the plurality of electrodes) and to the capacitors to charge the plurality of capacitors). The plurality of capacitors can be configured to, upon reaching a threshold charge, discharge to the plurality of electrodes (e.g.

Abstract: A surgical instrument (1) comprises at least three individual components (2,3,4,5,6) arranged movably relative to one another. Each of the individual components (2,3,4,5,6) is directly and movably connected to at least one further one of the individual components (2,3,4,5,6). All of the constituent parts of the surgical instrument (1) are made of a metallic or metal-containing material. Each individual component (2,3,4,5,6) has at least one friction surface region (9,10) which forms a pair of friction surfaces with at least one friction surface region (9,10) of another individual component (2,3,4,5,6). At least one of the two friction surface regions (9,10) of each pair of friction surfaces has a hard-material surface layer (16).

Abstract: Several heart wall remodeling devices and methods are disclosed. One heart wall remodeling device includes a trimming tool for trimming a line within a patient. The trimming tool includes an actuator for manipulation by a user, a moveable inner shaft coupled to the actuator, and an outer sleeve coupled to the inner shaft. The outer shaft includes a backstop disposed along an inner wall of the outer sleeve and a channel disposed between a first end and a second end of the outer sleeve. The inner shaft includes an inner shaft, a compressible member, and a cutter.

Abstract: Devices and methods for collecting tissue fragments of variable sizes from a surgical site are described herein. The devices can include at least two filters having a different pore size for the collection and sorting of tissue fragments by size.

Abstract: A cutting assembly in which an inner tube is rotatably disposed within an outer tube and defines as aspiration path. The inner tube may include segments, and the segments may define a flexible region associated with a bend of the outer tube. The outer tube may define irrigation channels, and further define irrigation apertures positioned proximal to a cutting window or distal to the flexible region. The irrigation channels fluidly separate the aspiration lumen from an irrigation path so as to prevent ingress of irrigation fluid into the aspiration lumen through slots defined by the segments. An inner jacket may be coaxially disposed within the inner tube and configured to provide a seal between the aspiration path and the irrigation path. A distal end of the inner jacket may be disposed in a counterbore, and the proximal end of the inner jacket may be proximal to the inner tube.

Abstract: In one aspect, the dual bevel needle can include a hollow tube having a proximal end, a distal end, a first lateral side, and a second lateral side opposite the first lateral side; a first needle point at the distal end of the hollow tube; a second point at the distal end of the hollow tube; a first bevel on each of the first lateral side and the second lateral side, the first bevel comprising a first bevel angle relative to a longitudinal axis of the tube; and a second bevel on each of the first lateral side and the second lateral side, the second bevel having a second bevel angle relative to the longitudinal axis of the tube, wherein the first and second bevels each form a portion of an ellipse, the ellipse having an inner cutting edge and terminating in the first and second needle points at the distal end of the tube, the second bevel angle being shallower than the first bevel angle, the second bevel being located adjacent the proximal end of the first bevel, and the inner cutting edge converging to a narr

Abstract: A surgical access assembly and method of use is disclosed. The surgical access assembly comprises an outer sheath and an obturator. The outer sheath and obturator are configured to be delivered to an area of interest within the brain. Either the outer sheath or the obturator may be configured to operate with a navigational system to track the location of either within the brain. Once positioned at a desired location, the obturator is removed, leaving a distal end of the outer sheath adjacent an area of interest, and creating a working corridor. Interrogation of the area of interest may be performed to evaluate a disorder and/or abnormality, as well as evaluate treatment regimes. Interventional devices may also be introduced to the area of interest, as well as a variety of treatments.

Abstract: A vessel harvesting device includes a handle and a cannula assembly extending distally from the handle. The cannula assembly includes an outer tube having a flange, and at least one insert extending within the outer tube. The at least one insert defines a tool path configured to receive a surgical tool therethrough, a scope path configured to receive a surgical scope therethrough, and an insufflation channel. The device further includes a cannula gasket disposed within the flange of the outer tube and defining a plurality of apertures each in alignment with one of the tool path, the scope path, and the insufflation channel. The device further includes an insufflation tube extending from the handle through cannula gasket and the insufflation channel.

Abstract: The present disclosure provides for an interlocking cannula system that includes a handle and a set of cannulas. The set of cannulas includes a sequence of smaller to larger cannulas constructed such that the smaller cannulas may be nested within larger cannulas. Each cannula in the set of cannulas includes a respective locking mechanism configured such that each cannula may be interlocked with each of the other cannulas in the set. The handle is constructed such that each cannula in the set may interlock with the handle by the respective locking mechanism of the cannula. In some instances, the respective locking mechanisms are constructed to enable an ordered release of the cannulas.

Abstract: A phoetal (i.e., fetal) extraction device including a frame configured to hold a biobag for receiving a baby, the frame having a distal end for insertion into a vagina, a longitudinal axis aligned with a insertion direction, and a radial direction. The frame includes frame members having distal end configured for insertion and proximal ends attached to a connecting element. The frame members extend away from the connecting elements and are circumferentially spaced apart around the longitudinal axis. The frame members are expandable in the radial direction such that a radial position of radial orientation of the frame members is adjustable relative to the connecting element. A kit of parts including at least the frame and the biobag.

Abstract: Systems and methods for joint replacement are provided. The systems and methods include a surgical orientation device and at least one orthopedic fixture. The surgical orientation device and orthopedic fixtures can be used to locate the orientation of an axis in the body, to adjust an orientation of a cutting plane or planes along a bony surface, to distract a joint, or to otherwise assist in an orthopedic procedure or procedures.

Abstract: A method of assembling a pivotal bone screw assembly includes applying tooling to a receiver assembly comprising a receiver with a channel for receiving a rod and a cavity with an interior support surface adjacent a lower opening, a retaining structure located in the cavity above the interior support surface, and an insert held in a first position above the retaining structure via a first interference engagement between the insert and the receiver. The method further includes uploading a capture portion of a shank through the lower opening until the capture portion is captured by the retaining structure, and then directly contacting the insert with the tooling to drive the insert downward to a second position to establish a biased overlapping engagement between the outer surface of the insert and the interior surface in the receiver that inhibits the insert from moving back up within the receiver to the first position.

Abstract: A spinal joint distraction system for treating a facet joint including articular surfaces having a contour is disclosed and may include a delivery device including a generally tubular structure adapted to engage a facet joint, an implant adapted to be delivered through the delivery device and into the facet joint, the implant comprising two members arranged in opposed position, and an implant distractor comprising a generally elongate member adapted to advance between the two members of the implant causing separation of the members and distraction of the facet joint, wherein the implant is adapted to conform to the shape of the implant distractor and/or the articular surfaces of the facet upon being delivered to the facet joint. Several embodiments of a system, several embodiments of an implant, and several methods are disclosed including a method for interbody fusion.

Abstract: Systems and methods for en bloc derotating a spinal column are provided. In one exemplary embodiment, the method can include manipulating first and second frames coupled respectively to a first set of vertebrae and a second set of vertebrae to derotate the first and second sets of vertebrae relative to one another, and subsequently locking a linkage assembly coupled respectively to the first and second frames to maintain the first and second sets of vertebrae in a derotated position.

Abstract: The present disclosure relates to a system comprising a dynamic locking bone plate and screw that provide a plate and screw complex for fracture fixation. The plate comprises a plurality of screw holes, each screw hole adapted to receive a screw. The screw threads allow for insertion into bone with compression of the plate to bone and the four male components on the screw head allow for the screws to be locked into place in the plate once they interact with the female components of the plate. The screw locking heads will come in two form, one plush fit to the locking plate and the other offset to allow some movement in the screw plate complex. On the under surface of the plate, the plate comprises a raised area or protrusion defining the bone to plate contact surface. The area between adjacent screw holes is adapted to allow for customisation by the surgeon intra-operatively for optimal fracture fixation.

Abstract: Devices, systems, and methods of bone stabilization. The bone stabilization system includes a bone plate having an upper surface and a lower surface configured to be in contact with bone, the bone plate having an opening extending from the upper surface to the lower surface. The opening is configured to receive a fastener, which may be either a locking fastener or a compression fastener.

Abstract: An engagement feature for selectively connecting a fastener such as a screw to a driving tool, the fastener incorporating a head with a tapered recess extending therein and a projection contained within the recess for engagement with a corresponding engagement feature and/or selective locking feature of the driving tool.

Abstract: An orthopedic bone screw includes a head, and a shaft extending from the head and comprising threads. The threads have a major diameter and a minor diameter. The shaft includes a threadless atraumatic tip opposite the head, the threadless atraumatic tip having a cylindrical portion that is distal of the threads and a round end portion that is distal of the cylindrical portion and forms a tip of the orthopedic bone screw. A length of the cylindrical portion of the atraumatic tip is 25% to 150% of the major diameter of the threads.

Abstract: Surgical constructs, assemblies, and methods for rotator cuff reinforcement are disclosed. Side tissue of a reconstructed rotator cuff is secured with at least one flexible coupler and at least one fixation device secured to bone.

Abstract: A tip for application of cryogenic matter onto a skin lesion includes a conduit configured to receive therein cryogenic matter; an absorbent application element configured to absorb and contain the cryogenic matter from the conduit and having an exposed face configured to apply the cryogenic matter directly onto the skin lesion; a thermally conductive material arranged in contact with at least a portion of the absorbent application element, said thermally conductive material configured to conduct cold from the absorbent application element and comprising a lip extending circumferentially at least partially around a perimeter of the exposed face; and a layer of insulating material disposed exterior to portions of the thermally conductive material. A device for application of cryogenic matter onto a skin lesion includes an applicator body with two opposing tweezer arms and at least one canister containing cryogenic matter; and first and second disposable tips.

Abstract: A tip for application of cryogenic matter onto a skin lesion includes a conduit configured to receive therein cryogenic matter; an absorbent application element configured to absorb and contain the cryogenic matter from the conduit and having an exposed face configured to apply the cryogenic matter directly onto the skin lesion; a thermally conductive material arranged in contact with at least a portion of the absorbent application element, said thermally conductive material configured to conduct cold from the absorbent application element and comprising a lip extending circumferentially at least partially around a perimeter of the exposed face; and a layer of insulating material disposed exterior to portions of the thermally conductive material. A device for application of cryogenic matter onto a skin lesion includes an applicator body with two opposing tweezer arms and at least one canister containing cryogenic matter; and first and second disposable tips.

Abstract: A tip for application of cryogenic matter onto a skin lesion includes a conduit configured to receive therein cryogenic matter; an absorbent application element configured to absorb and contain the cryogenic matter from the conduit and having an exposed face configured to apply the cryogenic matter directly onto the skin lesion; a thermally conductive material arranged in contact with at least a portion of the absorbent application element, said thermally conductive material configured to conduct cold from the absorbent application element and comprising a lip extending circumferentially at least partially around a perimeter of the exposed face; and a layer of insulating material disposed exterior to portions of the thermally conductive material. A device for application of cryogenic matter onto a skin lesion includes an applicator body with two opposing tweezer arms and at least one canister containing cryogenic matter; and first and second disposable tips.

Abstract: A tip for application of cryogenic matter onto a skin lesion includes a conduit configured to receive therein cryogenic matter; an absorbent application element configured to absorb and contain the cryogenic matter from the conduit and having an exposed face configured to apply the cryogenic matter directly onto the skin lesion; a thermally conductive material arranged in contact with at least a portion of the absorbent application element, said thermally conductive material configured to conduct cold from the absorbent application element and comprising a lip extending circumferentially at least partially around a perimeter of the exposed face; and a layer of insulating material disposed exterior to portions of the thermally conductive material. A device for application of cryogenic matter onto a skin lesion includes an applicator body with two opposing tweezer arms and at least one canister containing cryogenic matter; and first and second disposable tips.

Abstract: A minimally invasive body sculpting system and method is provided using a numbing component, a helium plasma component, and an NIL component. An NIL cannula of the NIL component is insertable into the body to remove the fat cell via nutational movement thereof and suction there through. Skin tightening is achieved through the subcutaneous exposure of the skin to helium plasma.

Abstract: Treatment of skin tissue with photoactive materials and light, such as nanoparticles and formulations which are useful for cosmetic, diagnostic and therapeutic applications to mammals such as humans. In particular, embodiments of thermal treatment of the skin surface with metal nanoparticles in surfactant containing solutions are disclosed.

Abstract: High-voltage pulses ablation systems and methods are used to ablate tissue and form lesions. A variety of different electrophysiology devices, such as catheters, surgical probes, and clamps, may be used to position one or more electrodes at a target location. Electrodes can be connected to power supply lines and, in some instances, the power to the electrodes can be controlled on an electrode-by-electrode basis. High-voltage pulse sequences provide a total amount of heating that is typically less than that which is observed with thermally-based radiofrequency energy ablation protocols.

Abstract: A device and method for creating an arteriovenous (AV) fistula includes a proximal base having a distal diagonal end surface and a distal tip connected to the proximal base and movable relative to the proximal base. The distal tip has a proximal diagonal end surface. A heating assembly, including an energized heating element, is disposed one of the distal diagonal end surface and the proximal diagonal end surface. A passive heating assembly is disposed on the mating diagonal end surface. The distal diagonal end surface and the proximal diagonal end surface are adapted to contact opposing sides of a tissue portion to create a fistula. The angle of the proximal diagonal end surface matches the angle of the distal diagonal end surface, so that the two surfaces match one another during deployment.

Abstract: A surgical device includes a handpiece having a socket, including a distal opening providing access to a passage having a longitudinal axis, and first and second electrical contacts located therein, wherein the contacts are displaced along the longitudinal axis so the first contact is more distal than the second. Also, a surgical instrument includes an elongate shaft having distal and proximal ends, wherein an end effector at the distal end is for treating tissue. Further, a connecting portion includes third and fourth electrical contacts, wherein the contacts are displaced along the shaft so the third contact is more distal than the fourth. The surgical instrument is coaxially coupled to the handpiece by the connecting portion received in the passage, so the first contact is aligned with the third and the second is aligned with the fourth to provide an electrical power signal from the handpiece to the surgical instrument.

Abstract: Presented are a method and apparatus for surgical procedures. An exemplary apparatus includes a body having a longitudinal axis, the body comprising a hollow passageway extending through the longitudinal axis from an inlet at a distal end to a port at a proximal end. The apparatus further includes an electrode extending from the distal end of the body adjacent to the inlet. The apparatus also includes a swivel portion moveably coupled to the port, the swivel portion having a second hollow passageway fluidly coupled to the hollow conduit extending from the port to an outlet, wherein the swivel portion comprises a first swivel element operable to rotate around the longitudinal axis relative to the body, and wherein the swivel portion comprises a second swivel element operable to rotate relative to the first swivel element and the body.

Abstract: A system for imaging and treating tissue can include or use an imaging sensor adapted to receive imaging information from a location internal to a human or animal subject, a tissue therapy output for applying a tissue therapy to tissue at the location internal to the subject, and controller circuitry, comprising signal-processing circuitry configured for image-processing the imaging information to determine a structure or other characteristic at or near the location internal to the subject, and to tailor a parameter or algorithm, controlling the tissue therapy output, at least in part based on the imaging information.

Abstract: Disclosed is a working end of a surgical instrument for delivering heat energy to tissue and (RF) energy for cutting tissue of different modalities. The working end includes paired first and second metal jaw members movable between open and closed positions, with each jaw member defining a jaw body and jaw end-effecter for engaging and heating tissue for the sealing of the tissue or vessels, or welding and coagulation of the tissue and jaw structure capable of generating radiofrequency (RF) energy for cutting tissue. Jaw members contain a microwave emitter coupled to a microwave energy source, the emitter is located within the jaw end effecter, which effecter includes an insert made of a microwave energy absorbing material which converts microwave energy into the heat energy. Jaw members also contain electrodes located within the jaw effecter end coupled to a radiofrequency (RF) energy source for procedures including tissue cutting, etc.

Abstract: An electrosurgical forceps includes a first shaft member including a first inner frame. A first jaw member extends distally from the first inner frame. A first outer housing is supported by the first inner frame. The first inner frame includes a first member stamped from sheet metal. A second shaft member includes a second inner frame. A second jaw member extends distally from the second inner frame. A second outer housing is supported by the second inner frame. The second inner frame includes a second member stamped from sheet metal and a rigid filler member disposed on the second member.

Abstract: Methods and systems for modulating intraosseous nerves (e.g., nerves within bone) are provided. For example, the methods and systems described herein may be used to modulate (e.g., denervate, ablate) basivertebral nerves within vertebrae. The modulation of the basivertebral nerves may facilitate treatment of chronic back pain. The modulation may be performed by a neuromodulation device (e.g., an energy delivery device).

Abstract: A system for treating and/or diagnosing tissue from a tissue surface comprises: a console; an interface assembly; and a mobile device. The mobile device is configured to navigate a tissue surface and can comprise: a first tissue attachment assembly; a second tissue attachment assembly; and at least one articulation assembly. The interface assembly operably connects the console to the mobile device. The console is configured to manipulate the at least one articulation assembly via the interface assembly. The at least one articulation assembly is configured to navigate from a first tissue location to a second tissue location. The mobile device is configured to diagnose and/or treat tissue at the second tissue location. Methods of treating and/or diagnosing tissue are also described.

Abstract: An apparatus includes a body, a catheter, and a deflection assembly. The catheter includes a proximal segment defining a first longitudinal axis, a medial segment defining a second longitudinal axis, and a distal segment. The deflection assembly is configured to deflect the medial segment away from the first longitudinal axis and to deflect the distal segment away from the second longitudinal axis. The deflection assembly includes first and second input members associated with the body. The deflection assembly also includes a first translating assembly coupled to the medial segment. The first input member is configured to drive the first translating assembly to deflect the medial segment away from the first longitudinal axis. The deflection assembly further includes a second translating assembly coupled to the distal segment. The second input member is configured to drive the second translating assembly to deflect the distal segment away from the second longitudinal axis.

Abstract: System and methods for enhancement of nonthermal electroporation using thermal ablation include a system having a catheter for providing concomitant thermal energy and electroporation and a controller for controlling the concomitant delivery of the thermal energy and electroporation. The method includes controlled application of thermal energy in conjunction with electroporation to increase a region of irreversible electroporation.

Abstract: An RF catheter for treating hypertrophic cardiomyopathy includes: a body part constituting a catheter body made of a flexible and soft material; and an intraseptal insertion part provided at a distal part of the body part and having one or more electrodes, a tapered tip gradually becoming thinner toward an end thereof, and a guidewire lumen therein, into which a guidewire is inserted, so that during hypertrophic cardiomyopathy treatment, the intraseptal insertion part is inserted into the interventricular septum along the guidewire. A method of treating hypertrophic cardiomyopathy by using an RF ablation catheter includes: i) positioning the guidewire to a hypertrophied septum through a coronary sinus and a septal vein; ii) transferring the RF ablation catheter to the hypertrophied septum; and iii) performing RF ablation by applying RF energy to the electrodes provided at an end part of the RF ablation catheter by using an RF generator.