Abstract: Therapeutic compositions and/or formulations are provided, comprising: at least one cross-linked protein matrix, wherein the at least one cross-linked protein matrix comprises at least one protein residue and at least one saccharide-containing residue, and methods of producing the same. The cross-linked protein matrix may be derived from cross-linking a full length or substantially full length protein, such as tropoelastin, elastin, albumin, collagen, collagen monomers, immunoglobulins, insulin, and/or derivatives or combinations thereof, with a saccharide containing cross-linking agent, such as a polysaccharide cross-linking agent derived from, for example, hyaluronic acid or a cellulose derivative. The therapeutic compositions may be administered topically or by injection. The present disclosure also provides methods, systems, and/or kits for the preparation and/or formulation of the compositions disclosed herein.

Abstract: A coated substrate is disclosed, including a solvent-sensitive substrate and a polyester coating disposed on the solvent-sensitive substrate, wherein the polyester coating includes a polyester copolymer of a polyol and a polyacid. A method for forming a coated substrate is disclosed including spraying solvated polyester material from a spray nozzle onto a solvent-sensitive substrate and drying the solvated polyester material to form a polyester disposed on the solvent-sensitive substrate, wherein the solvated polyester material and the polyester coating include a polyester copolymer of a polyol and a polyacid.

Abstract: Provided herein are implantable biomaterials for promoting regeneration of an injured biological tissue, the biomaterials including piezoelectric materials and an extracellular matrix specific to the injured biological tissue, wherein the piezoelectric materials and the extracellular matrix are electrospun together to provide tissue-specific bioactive piezoelectric nanofiber scaffolds. Also provided herein are methods of fabricating a tissue-specific bioactive piezoelectric nanofiber scaffold and methods of promoting regeneration of injured biological tissue by implanting the disclosed bioactive piezoelectric scaffolds.

Abstract: An injectable, moldable and printable gramular hydrogel material crosslinked by non-covalent and covalent bonds, a preparation method therefor, and applications thereof are provided. The material uses gelatin particles or particles that have core-shell structures as basic structural units, and forms a continuous and porous particle network by means of the reversible non-covalent crosslinking and covalent bond crosslinking of the particles. The gelatin particles or the particles that have core-shell structures form a continuous porous particle network by means of reversible self-assembly under the effect of the non-covalent bonds, thus achieving injectable, printable, moldable and self-healing properties. Furthermore, high strength granular hydrogels are formed by means of initiating covalent crosslinking. The material can be used as a drug-sustained release carrier, a tissue engineering scaffold and a tissue adhesive hemostatic material in the field of biomedicine.

Abstract: Disclosed is a method of manufacturing an artificial skin structure applied with a haptic technology, in which a polymer layer made of a PVC gel material is interposed between electrodes made of a hydrogel material to accurately recognize a pressing form, a pressing direction, and a pressing degree of external force based on a capacitance change value or resistance change value to the external force applied to the electrode made of a hydrogel material, and particularly, a material having excellent elasticity is applied to an electrode and a polymer layer itself to accurately recognize and utilize various motions, such as stroking, pinching, and twisting motions, instead of a simple pressing motion, and an artificial skin structure manufactured by the same.

Abstract: Compositions for forming porous materials and three-dimensional objects, including fibers, films and coatings made from the materials are provided. Also provided are methods for forming the porous objects from the compositions. The compositions include a solvent, a polymer binder that is soluble in the solvent, and solid particles that are insoluble in the solvent. The solid particles include water-soluble salt particles that can be selectively dissolved from objects made from the compositions to render the resulting structures porous.

Abstract: Provided is a novel device or a novel implantation device. The implantation device is one of the following: (1) an implantation device comprising a material (A) having a density of 12 mg/cm3 or more and a dissolution rate of 80% or less as determined after immersion of the material (A) in physiological saline at 37° C. for 24 hours; and (2) an implantation device comprising a material (A) having a dissolution rate of 80% or less as determined after immersion of the material (A) in physiological saline at 37° C. for 24 hours and a ratio of X/Y of 0.24 or more wherein X is a density (mg/cm3) of the material (A) and Y is a degree of swelling of the material (A) expressed in terms of fold increase as determined after immersion of the material (A) in physiological saline at 37° C. for 60 minutes.

Abstract: A bioflexible elastomer intestinal anastomosis stent based on a PTMC-b-PEG-b-PTMC copolymer, and a preparation method. Biocompatible degradable polymer medical materials, i.e., PTMC and PEG, are selected, an electrostatic spinning method is used for preparation, the size of an anastomosis tube can be adjusted according to the size of a human lumen, and the anastomosis tube is designed to not only be suitable for an anastomat of the small intestines and large intestines, but also suitable for an anastomotic and pre-supported lumen anastomat of an esophagus, artery, vein, etc. The anastomosis tube prepared has a thin wall and excellent elasticity, and in order to facilitate suturing by a doctor during a clinical surgical operation, the anastomosis tube is innovatively and seamlessly sleeved outside a plant cellulose tube having high hardness.

Abstract: A method for treating a respiratory condition of a patient with Alpha-2 Macroglobulin (?2M) molecules includes drawing whole blood, separating plasma containing ?2M molecules from other components of the whole blood, isolating the ?2M molecules from the other components of the plasma, and administering at least some of the isolated ?2M molecules to the patient via inhalation.

Abstract: A breast pump comprises abreast shield for fitting over at least the nipple of a breast thereby to create a cavity over the breast. A pump is used to deliver an under pressure to the cavity. In addition, a compressible chamber is used to manually create a reduced pressure in the cavity, in particular to function as a baseline pressure for holding the breast shield against the breast.

Abstract: Extracorporeal blood treatment systems and methods to display graphical user interfaces displaying a plurality of fluids areas, each including a flow rate, and displaying adjustment notifications proximate one or more fluid areas. For example, when a user adjusts a flow rate to a limit, one or more notifications may be displayed proximate other flow rates that may be adjusted to modify the limit.

Abstract: A dialysis system includes a fluidics system configured to perform a dialysis treatment session for a patient by having sensor(s) that measure corresponding parameter(s) and having dialysis actuator(s) that configures fluid flow through the fluidics system. The dialysis system includes a communication subsystem configured to communicatively connect to user device(s). A controller of the dialysis system is communicatively coupled to the fluidics system and the communication subsystem. The controller operates the fluidics system to perform the dialysis treatment session. The controller maintains data associated with the fluidics system. The data includes data types of patient health information, de-identified health information; and non-health information. The controller identifies access rights associated with first credential used by a first user device to the data types and communicates the data types to the first user device according to the access rights.

Abstract: Embodiments of the present disclosure provide a membrane oxygenator including an upper cover, a lower cover, a shell, and an oxygenation structure. Both ends of the shell are connected with the upper cover and the lower cover respectively. The oxygenation structure includes a mandrel, an oxygen pressure membrane, and a temperature-changing membrane, wherein an upper end of the mandrel enters a first blood path space of the upper cover, a lower end of the mandrel is opposite to a blood outlet of the lower cover, the oxygen pressure membrane is provided around the mandrel and connects a first gas path space and a second gas path space, and the temperature-changing membrane wraps around the oxygen pressure membrane. A gap is provided between the temperature-changing membrane and an inner wall of the shell. A blood inlet is provided on the shell near the upper cover.

Abstract: Despite therapeutic advances in the field of oncology, treatment toxicity, drug resistance, and inadequate tumor site delivery restrict the benefit of cancer chemotherapy regimens. Disclosed are extracorporeal devices comprising adsorbent components that are suitable for treating a subject prior to and following administration of a dose of a chemotherapy drug, wherein the devices are configured to remove circulating factors comprising a chemotherapy drug from blood or plasma. Also disclosed herein are methods of reducing the bloodstream presence of circulating factors that mediate drug resistance, drug toxicity, and cancer metastasis, wherein circulating factors include without limitation, tumor-derived and/or chemotherapy-induced extracellular vesicles or exosomes.

Abstract: An object is to ensure the connection quality of a pressure measuring device and achieve highly accurate pressure measurement so that fluid flow can be adjusted with high reliability.

Abstract: A triple syringe system that allows for a larger combined output of PRP (platelet rich plasma) and PPP (platelet poor plasma). The multi-syringe system allows for the connection of two or more additional syringes. The fractions may be extracted with the multi-syringe system of the present invention at different sequential times, or at the same time.

Abstract: According to certain embodiments, a surgical cassette for an ophthalmic surgical system comprises an irrigation conduit that is in fluid communication with a handpiece and carries fluid toward a surgical site. An aspiration conduit is in fluid communication with the handpiece and carries fluid away from the surgical site. An aspiration pump creates a vacuum pressure in the aspiration conduit to draw fluid through the aspiration conduit towards a drain reservoir. A reservoir couples with a pressure-vacuum source to manage the reservoir pressure. A valve is in fluid communication with the aspiration conduit and the reservoir, and provides one or more channels between the aspiration conduit and the reservoir. Each sensor detects a pressure associated with the surgical site. A computer controls the valve in response to the pressure detected by the one or more pressure sensors to mitigate a pressure or volume change.

Abstract: Methods and apparatuses for detecting full waste canister and/or fluid flow path blockage conditions are disclosed. Also disclosed are methods and apparatuses for controlling a pump. In some embodiments, flow of fluid can be restricted in a portion of the fluid flow path. A controller can be configured to compare a difference in pressure values upstream and downstream of a fluid flow restrictor to a pressure difference threshold, and determine based on the comparison whether to activate an alarm indicating the full waste canister condition or the fluid flow path blockage condition. The controller can be additionally or alternatively configured to determine a fluid flow using a flow meter, open a selectable valve in response to a comparison of the fluid flow with a fluid flow threshold, determine fluid flow after opening the valve, and determine based on the fluid flow after opening the valve whether to activate the alarm.

Abstract: Some embodiments are directed to a probe system for endoluminal negative pressure therapy with a probe tube, and a probe body, connected with the probe tube, which includes a basic body with an inner lumen and with at least one opening which leads from the inner lumen through an outer wall of the basic body to an outer side of the basic body, in which the probe body includes on the outer side of the basic body several rod-form structures and/or at least one lamella-form structure.

Abstract: Disposable nasal liquid dispenser device for dispensing a controlled quantity of a liquid solution into the nasal cavities and/or paranasal sinuses of a user, comprising: a liquid solution holding cylinder (1), said cylinder containing a quantity of liquid solution to be dispensed and comprising two cannulas (2) for dispensing the liquid solution into both nasal cavities simultaneously; two resilient nostril plugs (4) designed to seal the nostrils upon application therein, and comprising a discharge orifice (5) and coupling means (6) configured to be mounted on said cannulas (2); a piston (7) comprising elastic piston seals to offer sealing on the liquid solution holding cylinder (1) and designed to slide in an axial direction relative to said cylinder; and an actuator (8) configured to move the piston along the inside of the cylinder (1) upon manual actuation of a user.

Abstract: A wall-mounted insulin caddy according to the present invention includes a caddy body having a flat rear surface, an outer front surface, a pair of rounded corners, a top caddy body surface and a bottom caddy body surface, one or more removable adhesive strips coupled to the flat rear surface for mounting the caddy body to a wall and label on the outer front surface for identifying contents of any vials stored within the caddy body. The caddy body has a plurality of cylindrical storage locations, each of the plurality of cylindrical storage locations comprises a cavity within the caddy body accessible from a top caddy body surface for storing a vial, and a drainage hole from within the cylindrical storage locations through a bottom caddy surface. The caddy body reduces external light passing into vials placed within one of the plurality of cylindrical storage locations and .each of the plurality of cylindrical storage locations has a chamfered vial slot opening for easier vial installation.

Abstract: A system for infusing a gas into a vascular access device may include a catheter interface, which may include a distal end, a proximal end, and a lumen extending between the distal end and the proximal end. The system may also include a connector disposed on an outer surface of the catheter interface. The connector may be configured to couple to a reservoir. The reservoir may include a housing, which may include an opening and an impermeable wall. The opening may be configured to couple to the connector of the catheter interface. The reservoir may also include a molecular precursor to a gaseous agent that is suspended in a hydrogel and disposed within the housing. The gaseous agent may be antimicrobial, antithrombogenic, or both antimicrobial and antithrombogenic.

Abstract: An IV infusion set includes at least one infusion component, a first IV tube coupled to the infusion component, a second IV tube and a disposable pump head that. The pump head includes an inlet port coupled to the first IV tube, an outlet port coupled to the second IV tube and a drive interface configured to be coupled to a first end of a drive shaft. The drive interface is configured to be rotated by rotation of the drive shaft having a second end coupled to a driver to increase a fluid flow rate through the IV infusion set. IV set assemblies and methods of use are also provided.

Abstract: Infusion pump interfaces providing simple and intuitive user experiences. A controller display subsystem for implementing infusion pump interfaces includes a processor, a memory, display logic, keypad I/O, and screen I/O. Display logic can command the processor via the memory to implement desirable displays on screen I/O.

Abstract: A pump for delivering fluid from a reservoir to a patient includes at least one pumping syringe having a barrel and a plunger movable through the barrel and at least one actuator for moving the plunger through the barrel to draw the fluid from the reservoir into the barrel and to expel the fluid from the barrel towards the patient. The pump also includes at least one inflow valve between the reservoir and the barrel of the at least one pumping syringe that opens when the plunger moves to aspirate the fluid from the reservoir into the barrel; and at least one outflow valve between the barrel of the at least one pumping syringe and the patient that opens when the plunger moves to expel the fluid from the barrel of the at least one pumping syringe towards the patient.

Abstract: Pump assemblies for use with an IV set are described herein. A pump assembly includes a rotatable crank, a piston rod, and a diaphragm assembly. The crank includes a crank profile defining a plurality of lobes. The piston rod includes a first follower and a second follower spaced apart from the first follower. The rotation of the crank relative to the piston rod causes the piston rod to reciprocate relative to the crank. The diaphragm assembly includes a housing and a diaphragm member. The diaphragm member is coupled to the housing and cooperatively defines a volume in fluid communication with the IV set. The diaphragm member is movable between an extended position configured to draw in fluid from the IV set and a contracted position configured to expel fluid into the IV set. The diaphragm member is coupled to the piston rod to reciprocate the diaphragm member.

Abstract: A drug delivery device includes a housing, a container disposed in the housing, an activation mechanism, a needle insertion mechanism, and a fluid flow path. The container has an inner volume to contain a medicament which is urged out of the container by the activation mechanism. The needle insertion mechanism includes an actuation assembly adapted to insert a needle and a cannula to deliver the medicament from the container and a valve assembly. The fluid flow connection is coupled with the container and the needle insertion mechanism and is adapted to allow the medicament to flow from the container to the needle insertion mechanism. The valve assembly is repeatedly movable between at least a valve open position and a valve closed position to selectively allow and restrict the medicament to flow through the needle and/or the cannula.

Abstract: A drug delivery device comprising a pumping system (4) and a liquid reservoir (7) fluidly connected to a delivery system outlet (12), the liquid reservoir comprising an elastic plunger (14) scalingly slidable within a container wall (13) of the liquid reservoir for expelling liquid out of the reservoir. The pumping system comprises a piston pump (5) comprising a plunger actuator arranged to displace the plunger (14), and a dosing unit (6) arranged downstream of the liquid reservoir (7) and fluidly connected to the liquid reservoir. The dosing unit (6) comprises a chamber portion (22) arranged between an inlet valve (24) and an outlet valve (26), the chamber portion (22) arranged to receive from the liquid reservoir a pump cycle volume of liquid under an operational pressure greater than ambient pressure generated by the piston pump, and to the deliver said pump cycle volume of liquid to the delivery system outlet, said pump cycle volume being dependent on the operational pressure.

Abstract: Disclosed is a method for controlling an electrochemical pump, comprising: providing an electrochemical pump, and causing a control circuit of the electrochemical pump to generate a pulse signal to enable an electrochemical reaction on electrodes of the electrochemical pump, wherein the pulse signal has alternating on-periods and off-periods where the pulse signal is off, and wherein each on-period has a plurality of on-times where the pulse signal is on and a plurality of off-times where the pulse signal is off, the on- and off-times being alternatingly arranged.

Abstract: Activatable medicament delivery containers and assemblies are disclosed that can be activated to direct a medicament from the container using an expandable material that causes an expansion chamber to displace the medicament from the container, where the medicament can be directed from the container at a predetermined or use-specific rate, and for a predetermined period of time, and the container being couplable with a dock to form an activatable medicament delivery assembly, where the container can be removably coupled or replace with the dock, and where the dock can be coupled directly to an intravenous fluid delivery device.

Abstract: An infusion set includes a base (221) and a flexible catheter (242) movable from a first catheter position disposed substantially entirely within the base (221) to a second catheter position in which a free end of the catheter (242) is disposed externally of the base (221). An introducer needle (234) is located within the catheter (242) and is movable between a first introducer needle position disposed substantially entirely within the base (221) and a second introducer needle position in which a free end of the introducer needle (234) is disposed externally of the base (221). A spring (281) is activated to move the catheter (242) from the first to the second catheter position and the introducer needle (234) from the first to the second introducer needle position to facilitate insertion of the catheter (242).

Abstract: A medicament delivery system (1) and method for determining an occlusion comprising a reservoir (4) that carries a medicament, a pump (3) connected to the reservoir (4) that draws the medicament out of the reservoir (4) for medication delivery, and an occlusion sensor (600) connected to the reservoir (4) that senses whether an occlusion is present wherein the occlusion sensor (600) is secured to an outer surface of the reservoir (4), the occlusion sensor (600) provides resistance output (630) to control electronics (8), and the control electronics (8) determines whether an occlusion is present based on the resistance output (630). The occlusion sensor (600) can be a strain gauge bonded onto a mid-section of an outer surface of a flexible reservoir (4) to provide a sensitive strain reading.

Abstract: Disclosed are techniques, devices and systems that provide adjustments to parameter settings of an insulin delivery algorithm based on inputs from a number of generic sensor devices. A majority of the generic sensor devices provide sensor readings that are unused as inputs to a drug deliver algorithm. The generic sensor devices may be operable to detect characteristics, such as changes in a state of a user. A processor may evaluate a sensor reading provided by a particular sensor with respect to a sensor baseline reading for the particular sensor. Using the result of the evaluation, the processor may calculate an adjustment to a parameter setting or settings of a medication delivery algorithm. A dosage of medication may be modified based on the adjustment of the parameter setting or settings.

Abstract: An electronic automatic injection device including a housing configured to receive an injection module containing a material to be injected, an electric motor having a rotary drive output, at least one forward driving spring and a multifunctional electric motor driven drive assembly responsive to the rotary drive output of the electric motor and being operative in a first mode of operation, when the injection module includes a prefilled syringe, to enable the at least one forward driving spring to displace the prefilled syringe in a forward direction and in a second mode of operation, when the injection module includes a needleless cartridge, to eject the injectable liquid from the prefilled syringe through a needle.

Abstract: The present disclosure pertains to a syringe comprising: a syringe barrel having an open proximal end that opens into an interior having a cylindrical wall and an angled distal surface terminating at an outlet; a plunger rod; and a plunger seal, a proximal end of the plunger seal configured to be attached to a distal end of the plunger rod, and a distal end of the plunger seal configured to be inserted into the interior of the syringe barrel through the open proximal end, the plunger seal forming a seal with the cylindrical wall of the interior of the syringe barrel, and the distal end of the plunger seal terminating at an angled distal surface, wherein the angled distal surface of the syringe barrel is more acute than the angled distal surface of the plunger seal. The present disclosure also pertains to kits containing such a syringe.

Abstract: A medicament delivery device configured to provide a variable single dose of medicament is disclosed. The medicament delivery device includes a main body and a syringe arranged in the main body, wherein the syringe comprises a medicament. The medicament delivery device further includes a removable cap and a plunger rod operatively arranged to eject the medicament through a delivery member i.e. an injection needle attached to the syringe. Still further, the medicament delivery device includes a tubular member coupled to the plunger rod. The tubular member is configured to rotate during removing of the removable cap, and the rotation releases the plunger rod thereby allowing the plunger rod to travel a predetermined distance so as to prime the medicament delivery device.

Abstract: Plunger assemblies (20) including a plunger sleeve (34), a plunger rod (22), and an axial protrusion (30) disposed within an inner cavity (40) of the plunger sleeve. Application of a distal force onto the plunger via the plunger rod causes the axial protrusion to contact and apply pressure to an engagement surface (50) in the inner cavity. The engagement surface is configured to receive distal force from the end of the axial protrusion. This causes the plunger to elongate and slightly constrict, thus reducing break loose force and facilitating transition from storage mode to dispensing mode of the plunger.

Abstract: A drug delivery device may include a housing defining a longitudinal axis and having an opening and a drug storage container including a delivery member having an insertion end configured to extend at least partially through the opening during a delivery state. The device may also include plunger moveable toward the distal end of the drug storage container to expel a drug from the drug storage container through the delivery member, the plunger including a body portion having an inner wall defining an axial chamber and an outer wall cooperating with the inner wall to define a body thickness. The device may further include a plunger biasing member disposed at least partially within the axial chamber, the plunger biasing member configured to urge the plunger toward the distal end of the drug storage container.

Abstract: A dose counting system of an injection device or of a module configured to be used with or applied to an injection device is described. The dose counting system includes a sensor arrangement including a first sensor configured to output a first signal and a second sensor configured to output a second signal; and a processor configured to: detect a peak in the first signal when the first signal has increased by at least a predefined up threshold and the first signal exceeds the value of the second signal by more than a predetermined crossover threshold; determine that a unit of medicament has been administered when the first signal drops from the peak by more than a predefined down threshold and the preceding peak occurred in the second signal; and determine a medicament dosage administered by the injection device by counting the administered units of medicament.

Abstract: An electronic device comprising: a housing for attachment to an injection device; a first sensor assembly comprising a first coil and two magnets of opposite polarity, wherein the first coil is configured to provide a first voltage pulse as a first Wiegand wire of the injection device moves from a first position proximate to one of the magnets of the first sensor assembly to a second position proximate to the other magnet of the first sensor assembly; and one or more processors configured to enter an enabled state from a sleep state after receiving the first voltage pulse from the first coil.

Abstract: The present invention relates to a medicament delivery device for delivering a number of predetermined amounts of medicament, comprising a body having a proximal and an opposite distal end and extending along a longitudinal axis (L); a medicament container (20) arranged inside said body; a driving mechanism arranged inside said body and configured to act on said medicament container; a manually movable activation member (102) arranged on the distal end the body; a biased actuator member (64) arranged to be movable along the longitudinal axis and through the manually movable activation member (102), said biased actuator member being configured to protrude a predetermined distance from the distal end of the manually movable activation member and configured to interact with said driving mechanism when the biased actuator member is displaced said predetermined distance towards the proximal end of the body for delivering a predetermined amount of medicament; and an actuator guide member (90) arranged in the body a

Abstract: The present disclosure relates to an injector device comprising: a housing having a distal end and a proximal end; a medicament cartridge disposed within the housing; a needle unit comprising a needle, the needle unit being disposed in the distal end of the housing; and a button disposed in the proximal end of the housing, the button being configured to move the cartridge onto the needle unit to fluidly connect the needle with the cartridge when, in use, the button is pressed from an initial position into a depressed position.

Abstract: A method and an apparatus for applying an anesthetic that includes a receptacle having an upper end, a substantially hollow interior, a lower end having a tube or nozzle extending therefrom, and an attachment for attaching to the barrel of a syringe or vice versa. The receptacle receives a container or canister containing an endothermic gas or vapor (propellant) that rapidly absorbs heat when released to the atmosphere. A depressible actuating member or trigger propels the gas or vapor through an outlet nozzle that is oriented to project a stream of gas or vapor along a delivery axis that intersects a delivery axis of the needle, therefore, the gas or vapor can be successively delivered to an injection site with minimal repositioning of the housing.

Abstract: The present invention generally provides a device for inserting needles and alleviating the discomfort associated with needle insertion. In certain embodiments, the device is suited for injecting butterfly needles and particularly butterfly needles that are attached to infusion tubing. The patient or caregiver loads a butterfly needle with tubing attached into the base of the drive plunger. The needle with tubing attached is retracted into the housing of the device by retracting the inner plunger. Once retracted, the device is activated and ready to administer a needle into the tissue of a patient. The device is then placed on the location of the skin where injection is desired. The surface that contacts the skin may be textured and may include a contact switch that causes the device to vibrate when slight pressure is applied through contact with the skin.

Abstract: A pulmonary delivery device (300) with a first chamber (206) adapted to thermally vaporise a quantity of a first fluid to form a relatively warm first vapour and a second chamber (208) adapted to atomize a quantity of a second fluid without heating of the second fluid to form a mist of a relatively cold, second vapour, the device further comprising an outlet via which, in use, a user can inhale a mixture of the first and second vapours. The second chamber is in the form of a passive atomiser wherein the second chamber is selectively or continuously in fluid communication with air, the second chamber including at least one flavouring or aroma wherein the flavour is inhaled by drawing air through the chamber.

Abstract: This disclosure provides an ophthalmological surgical tool to perform transretinal pneumatic displacement of sub-retinal hemorrhage, and uses thereof. The surgical tool comprises a gas cannula which is configured to dispense air or medical gas in an air-knife pattern to displace or disrupt sub-retinal hemorrhage away from the macula.

Abstract: Various exemplary drug delivery devices with a multi-dispensing head, drug products utilizing the same, and methods of using drug delivery devices with a multi-dispensing head are provided. In general, a nasal drug delivery device is configured to dispense a drug therefrom into a nose. In an exemplary embodiment, the drug delivery device includes two tips each configured to be positioned in or adjacent to a nostril. The two tips are configured to be positioned in or adjacent to the nostrils simultaneously.

Abstract: A method for evaluating inhalation administration and a system for evaluating inhalation administration, the system including a flow detector and an intelligent terminal. The method includes the following steps: 1) obtaining patient-related data of an inspiration flow-time curve; 2) according to an inspiration flow parameter of inhalation administration, obtaining a start time and an end time of each effective inspiration flow section on the inspiration flow-time curve; and 3) calculating an effective inspiration volume Veffective based on the inspiration flow-time curve and a series of time parameters ti1 and ti2 obtained. The method for evaluating inhalation administration and the system for evaluating inhalation administration provide a basis for medical workers to select an appropriate inhalation administration device for patients.

Abstract: The invention relates to an ultrasonic mist inhaler, comprising: a liquid reservoir structure comprising a liquid chamber adapted to receive liquid to be atomized, the liquid chamber comprising a top surface representing the maximum level of the liquid chamber and the bottom surface representing the minimum level of the liquid chamber, a sonication chamber in fluid communication with the liquid chamber, the sonication chamber compring means of ultrasonic vibrations and a capillary element extending between the sonication chamber and the liquid chamber, wherein the means of ultrasonic vibrations and the liquid chamber are arranged according to one of the following configurations: the means of ultrasonic vibrations are disposed close to or at the bottom surface of the liquid chamber, the means of ultrasonic vibrations are disposed close to or at the top surface of the liquid chamber as depicted in FIG. 3.

Abstract: A stand-alone chamber or multi-chamber inhalation system has at least two alternative vaporized test liquid supply systems for passive or self-administered delivery of vaporized test fluid and air to one or more test chambers, which can be passive or restraint chambers, based on operator selection of delivery on and off times in a passive mode or actuation of an actuator in the chamber by a test animal in a self-administered mode. In one case, a multiple inhalation chamber system has two or more separate test fluid delivery systems and provides options for selective passive uniform drug delivery to multiple chambers or selective delivery of two or more different drugs to different groups of chambers from different delivery systems so that two different drugs or different concentrations of delivered drugs can be tested simultaneously.