Patents Issued in March 28, 2024
  • Publication number: 20240100321
    Abstract: An apparatus for providing Tumor-Treating Fields comprises an electrode layer having a plurality of electrode elements. First and second electrode elements are spaced apart within the electrode layer along a first axis. The electrode layer has at least one filler structure having a first filler portion positioned within a space between the first and second electrode elements. The at least one filler structure is configured to provide the electrode layer with a substantially consistent height along the first axis. The apparatus can further have an upper adhesive layer, a lower adhesive layer, and a layer of anisotropic material therebetween. The plurality of electrode elements can be in electrical contact with the outwardly facing surface of the layer of anisotropic material.
    Type: Application
    Filed: September 22, 2023
    Publication date: March 28, 2024
    Inventors: Yoram Wasserman, Stas Obuchovsky, Nataliya Kuplennik, David Shapiro, Avishai Nahshoni
  • Publication number: 20240100322
    Abstract: A transducer array for use in tumor-treating fields (TTFields) therapy is particularly suited for use in treating abdominal or thoracic cancers. The transducer array has features that increase its flexibility and adhesion to the patient's skin, including a branching configuration and a correspondingly branching top covering adhesive-backed layer. Additionally, a skin-level adhesive layer is provided beneath the flex circuit to which the electrode elements are attached, to help ensure thorough, lasting adhesion of the transducer array to the patient's skin over the course of treatment.
    Type: Application
    Filed: December 7, 2023
    Publication date: March 28, 2024
    Applicant: Novocure GmbH
    Inventors: Eilon KIRSON, Yoram Wasserman, Noa Halavee
  • Publication number: 20240100323
    Abstract: A medical device lead connector includes electrically conducting contact rings spaced apart by an electrically insulating ring and in axial alignment. The electrically conducting contact ring and the insulating ring having an interface bond on an atomic level.
    Type: Application
    Filed: December 6, 2023
    Publication date: March 28, 2024
    Inventors: Darren A. Janzig, Andrew J. Thom, Chris J. Paidosh, Brad C. Tischendorf, Gerald G. Lindner
  • Publication number: 20240100324
    Abstract: Disclosed herein is a device capable of high efficiency DNA electrotransfer into cells via a single capacitive discharge. The principle of this system relates to the storage of a quantum of charge on a capacitor which is then discharged through an electrode array configured to produce an electric field having electric field potential gradients focused through a region by the array configuration and of sufficient in strength for efficient electrotransfer of DNA into cells. This DNA, or related ribonucleic acid molecules or indeed other charged molecules, upon entering the cells, can affect changes in biological function.
    Type: Application
    Filed: October 16, 2020
    Publication date: March 28, 2024
    Inventors: Gary David Housley, Jeremy Pinyon, Nigel Hamilton Lovell, Edward Norman Crawford, Amr Al Abed, Georg Von Jonquieres
  • Publication number: 20240100325
    Abstract: A fixation component includes tines extending from a base portion of the fixation component. Each tine is elastically deformable between a pre-set position and an open position. Each tine includes a hook segment extending from a proximal end near the base portion to a distal end. Each tine also includes a distal segment extending from the distal end of the hook segment to a tissue-piercing tip. When positioned in the pre-set position, the hook segment extends along a pre-set curvature that encloses an angle between 135 degrees and 270 degrees, and the distal segment extends away from a longitudinal axis of the fixation component.
    Type: Application
    Filed: December 5, 2023
    Publication date: March 28, 2024
    Inventors: Jonathan L. Kuhn, Michael P. Campbell, Vladimir Grubac, Kenneth D. Rys, Richard W. Swenson, Charles Lowell Wilson
  • Publication number: 20240100326
    Abstract: A system and a method for increasing permeability of a brain barrier selected from a blood-brain barrier or a blood-cerebrospinal fluid barrier by controlled application of pulsed electric fields.
    Type: Application
    Filed: November 30, 2023
    Publication date: March 28, 2024
    Inventors: Yael MARDOR, Shirley SHARABI, Itzik COOPER, David LAST, David GUEZ, Dianne DANIELS ELMAKIAS, Yael BRESLER
  • Publication number: 20240100327
    Abstract: Described herein are methods and devices for monitoring or modulating an immune system in a subject with cancer, and methods and devices for treating a cancer in a subject. The implanted device can electrically stimulate the splenic nerve of the subject, which can modulate the inflammatory system (for example, by increasing or decreasing the blood level of one or more pro-inflammatory cytokines and/or anti-inflammatory cytokines to increase or decrease inflammation in the subject) and/or activate or increase circulation of one or more immune cells (such as natural killer cells and/or cytotoxic T-cells), for the treatment of cancer. The implanted medical device includes two or more electrodes configured to electrically stimulate the splenic nerve, and may further include an ultrasonic transducer configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy that powers the device.
    Type: Application
    Filed: October 16, 2020
    Publication date: March 28, 2024
    Inventors: Jose M. CARMENA, Michel M. MAHARBIZ, Ryan NEELY, Joshua KAY, Giana MONTERO GARNIER
  • Publication number: 20240100328
    Abstract: Embodiments of the present invention provide a system (100) for providing targeted cue delivery to regulate a gait of a user comprising a first cue delivery device (131) configured to provide somatosensory stimulation to a first leg of the user, a second cue delivery device (132) configured to provide somatosensory stimulation to a second leg of the user, one or more inertial sensors (121, 122) configured to output movement data indicative of the gait of the user, and a controller (110) configured to receive the movement data from the one or more inertial sensors (121, 122), determine a cue pattern for each of the first and second cue delivery devices (131, 132) independence on the movement data, and output a respective control signal (135, 136) to control each of the first and second cue delivery devices (135, 136) to provide stimulation according to the cue pattern.
    Type: Application
    Filed: October 22, 2020
    Publication date: March 28, 2024
    Inventors: James CANTLEY, Dongli LI
  • Publication number: 20240100329
    Abstract: The embodiments and methods described herein relate to an improved functional electrical stimulation (FES) orthosis. An apparatus can include a frame assembly, an electrode assembly, and an electric stimulator. The frame assembly is removably coupleable to a portion of a limb. The electrode assembly is configured to be in electrical communication with a portion of a neuromuscular system of the limb, and includes first and second sets of electrodes. The electric stimulator is in electrical communication with the electrode assembly. The electric stimulator is configured to send a first signal substantially during a first time period and via a first channel to the first set of electrodes for stimulation of a neuromuscular system of the limb, and is configured to send a second signal, during at least one of the first time period or a subsequent second time period, via a second channel to the second set of electrodes for stimulation of the neuromuscular system of the limb.
    Type: Application
    Filed: June 22, 2023
    Publication date: March 28, 2024
    Applicant: Bioness Inc.
    Inventor: Keith Sean MCBRIDE
  • Publication number: 20240100330
    Abstract: The present disclosure provides an electrically assisted muscle pumping (EAMP) system and a method. The system includes sensors to measure an acceleration of a user. The system includes a processor operatively coupled with the sensors, to register an orientation of the user. Electrodes may be operatively connected to stimulation signal generators to generate electrical stimulation signals. Implanted helical wire structure electrodes are placed inside the user and operatively connected to the electrodes to receive the electrical stimulation signals from the electrodes and transmit the electrical stimulation signals to nerves inside the body of the user. The stimulation signal generators are operatively connected to the processor and adapted to apply electric currents to the electrodes. A recorder is connected to the sensors and the stimulation signal generators to capture the acceleration of the user and the electric currents applied to the electrodes.
    Type: Application
    Filed: September 27, 2023
    Publication date: March 28, 2024
    Inventors: Manfred Franke, Stephan Nieuwoudt
  • Publication number: 20240100331
    Abstract: Embodiments of the invention provide apparatus and methods for stimulating L cells in the intestinal tract to produce incretins for the treatment of conditions including diabetes and obesity. Many embodiments provide a method and apparatus for the treatment of diabetes by electrically stimulating L-cells to secrete incretins to stimulate or otherwise modulate the production of insulin. Particular embodiments provide a swallowable capsule for stimulating L-cells in the intestinal tract as the capsule moves through the tract. The capsule can include two or more electrodes for providing electrical stimulation to L-cells, a power source for powering one or more components of the capsule, a sensor for sensing the location of the capsule in the intestinal tract; a controller and a waveform generator for generating the electrical signals emitted by the electrodes to stimulate the L-cells to secrete incretins such as GLP-1 to stimulate insulin production for glucose regulation of diabetic conditions.
    Type: Application
    Filed: December 7, 2023
    Publication date: March 28, 2024
    Inventors: Mir A. IMRAN, Mir HASHIM, Emily ARNSDORF
  • Publication number: 20240100332
    Abstract: A respiration promoting apparatus and a method for promoting respiration for coordinately stimulating two Phrenic nerves of a patient for activating a diaphragm of the patient comprising a first coil unit (91), a second coil unit (92) and a bracket structure (93). The first coil unit (91) has a first forward face (911) configured to be positioned at the patient to stimulate a first Phrenic nerve of the two Phrenic nerves (62) of the patient. The second coil unit (92) has a second forward face (921) configured to be positioned at the patient to stimulate a second Phrenic nerve. The bracket structure (93) is coupled to the first coil unit (91) and the second coil unit (92) and is adjustable such that positions and orientations of the first coil unit (91) and of the second coil unit (92) are adapted. The bracket structure (93) has a third forward face (918, 928, 932) configured to be positioned at the patient.
    Type: Application
    Filed: October 19, 2020
    Publication date: March 28, 2024
    Inventors: Pascal André SCHNELL, Thomas DEGEN, Dirk FENGELS, Ronja MÜLLER-BRUHN
  • Publication number: 20240100333
    Abstract: A system for delivering more than one energy waveform to a patient. The system comprising a first pair of electrodes and a second pair of electrodes adapted to be positioned on the patient and adapted to deliver energy to the patient, a stimulation pad comprising the first pair of electrodes and the second pair of electrodes, and a stimulation control unit in communication with the first and second pairs of electrodes. The stimulation control unit configured to combine a first energy waveform having a first frequency and a second energy waveform having a second frequency into a multiplexed signal, and deliver the multiplexed signal to the first pair of electrodes and the second pair of electrodes.
    Type: Application
    Filed: December 11, 2023
    Publication date: March 28, 2024
    Applicant: Sage Products, LLC
    Inventor: Brian J. Fahey
  • Publication number: 20240100334
    Abstract: Methods, systems, and apparatus for causing changes to cells or tissue within or adjacent to an eye. The system includes an external RF coil configured to transmit RF signals. The system also includes a wearable device configured to be removably disposed on the eye, the wearable device including a plurality of internal radiofrequency (RF) coils configured to receive the RF signals from the external RF coil and a plurality of stimulating electrodes configured to electromagnetically stimulate a portion of the eye or an area adjacent to the eye, causing changes to cells or tissue within or adjacent to the eye.
    Type: Application
    Filed: October 28, 2020
    Publication date: March 28, 2024
    Inventors: Mark S. Humayun, Gianluca Lazzi, Bodour Salhia, Manjunath Machnoor, Javad Paknahad
  • Publication number: 20240100335
    Abstract: A device for stimulating one or more eye functions of individual's eye is presented. The device comprises a stimulator for incorporating in mounting on an appliance attachable to individual's face and comprising respective stimulator arrangement(s) defining an interface region for covering a region of interest on the individual's face in a vicinity of the respective individual's eye. The stimulator arrangement comprises a local controller operating to apply a stimulating effect on one or more nerves in the region of interest to affect predetermined eye function(s), and an array of individually operable stimulating elements each generating a stimulating signal at a respective location in the interface region. The local controller activates a predetermined individual-specific sub-array of the stimulating elements, where locations of the stimulating elements of the sub-array provide a desired spatial pattern of the stimulating effect to be applied while avoiding stimulating effect outside said locations.
    Type: Application
    Filed: December 11, 2023
    Publication date: March 28, 2024
    Inventors: Iftach YASSUR, Gal ANTMAN, Alon TIOSANO, Omer ZARCHI, Raz KARL
  • Publication number: 20240100336
    Abstract: Methods for electrical modulation of inflammation or serum TNF levels in a subject.
    Type: Application
    Filed: September 27, 2023
    Publication date: March 28, 2024
    Inventors: Adam M. Kressel, Valentin A. Pavlov, Sangeeta S. Chavan, Kevin J. Tracey
  • Publication number: 20240100337
    Abstract: A method for controlling connectivity between two or more brain regions of a subject includes receiving signals corresponding to a connectivity between two or more regions of a subject's brain, measuring a connectivity level from the signals, and delivering at least one stimulation pulse to at least one target region of the subject's brain if the measured connectivity level is outside of a predetermined range.
    Type: Application
    Filed: January 26, 2022
    Publication date: March 28, 2024
    Applicants: REGENTS OF THE UNIVERSITY OF MINNESOTA, ÉCOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE (EPFL), CORNELL UNIVERSITY
    Inventors: Alik WIDGE, Gregory MOLNAR, Virginia WOODS, Mahsa SHOARAN, Uisub SHIN
  • Publication number: 20240100338
    Abstract: Embodiments of a method for treating a patient suffering from chronic pain are described. A source location of chronic pain in a patient is first identified. A regional anaesthetic is then used to temporarily block selected nerves to confirm the source location and identify a target nerve. An electrode array of a neuromodulation apparatus is then implanted in the patient over the target nerve, such as just under the stratum corneum, and the neuromodulation apparatus is then used to stimulate the electrode array to create a long term conduction block that provides persistent pain relief to the patient.
    Type: Application
    Filed: December 18, 2020
    Publication date: March 28, 2024
    Applicant: SPECIALISED PAIN MEDICINE PTY LTD
    Inventors: Philip CORNISH, Anne CORNISH
  • Publication number: 20240100339
    Abstract: The present invention relates to a system for use in the treatment or prevention of disease or symptoms thereof, the system comprising: at least one object, wherein the object is configured for being positioned in or adjacent to the pituitary gland or the pituitary stalk of a subject; and a device configured to generate at least one intermittent stimulating signal in the object, wherein the signal subsequently activates a release of biologically active agents.
    Type: Application
    Filed: February 17, 2022
    Publication date: March 28, 2024
    Applicant: Academisch Ziekenhuis Leiden (H.O.D.N. LUMC)
    Inventor: Wouter R. VAN FURTH
  • Publication number: 20240100340
    Abstract: Provided is a device for relieving headache and pain caused by temporomandibular joint disorders may include: a body having a neck band surroundingly worn on a user's neck, first connectors extending forwardly from both ends of the neck band by first set lengths, and second connectors extending upwardly from front ends of the first connectors by second set lengths; first low frequency electrostimulators disposed on the second connectors and coming into close contact with the temporalis muscles, when the body is worn on the user's head, to apply low frequencies to the temporalis muscles; and second low frequency electrostimulators disposed on the connected portions between the first connectors and the second connectors and coming into close contact with the masseter muscles, when the body is worn on the user's head, to apply low frequencies to the masseter muscles.
    Type: Application
    Filed: December 8, 2023
    Publication date: March 28, 2024
    Inventors: Tae Hun KIM, Won Sik BAE, Jae Hyeong OH, Dong Jin YOU
  • Publication number: 20240100341
    Abstract: Neuromodulation of cranial nerves can be used to treat sleep or breathing disorders, among other diseases and disorders. A neuromodulation system can include a housing configured for implantation in an anterior Cervical region of a patient, such as at or under a mandible of the patient, such as at least partially in one or mote of a submental triangle, a submandibular triangle, and a carotid triangle. The system can include an electrode lead coupled to the housing, and the electrode lead can include an electrode configured to be disposed at or near a cranial nerve target in the patient. The system can be configured to generate electrical neuromodulation signals for delivery to the cranial nerve target using the electrode.
    Type: Application
    Filed: October 4, 2023
    Publication date: March 28, 2024
    Inventors: Lynn Elliott, Stephen C. Masson, JR.
  • Publication number: 20240100342
    Abstract: Devices, systems, and techniques are described that use electric field imaging (often referred to as the sensed stimulation artifact representative of a delivered stimulus) as an informative feedback signal to provide closed loop control of electrical stimulation therapy. In some examples, the electric field imaging may be used in combination with other feedback signals, such as ECAP do monitor and adjust the delivered electrical stimulation therapy.
    Type: Application
    Filed: February 23, 2022
    Publication date: March 28, 2024
    Inventors: Jerel K. Mueller, Leonid M. Litvak, Vinod Sharma, Katelynn M. Johnson, Jiashu Li
  • Publication number: 20240100343
    Abstract: An implantable neuromodulation system can include an electrode configured to be disposed at or near a first branch of a hypoglossal nerve of a patient and configured to provide a first electrostimulation therapy to treat a sleep disorder or breathing disorder of a patient. The system can include a sensor configured to provide a sensor signal that includes information about a patient response to the first electrostimulation therapy. The patient response can include at least one of an acoustic profile of an airway of the patient, a change in a position of a tongue of the patient, and information about an evoked compound action potential (ECAP) of a portion of the hypoglossal nerve. In an example, a processor circuit can use information from the sensor signal to select a subsequent electrostimulation therapy to treat the sleep disorder or breathing disorder of the patient.
    Type: Application
    Filed: August 23, 2022
    Publication date: March 28, 2024
    Inventors: Stephen C. Masson, JR., Lynn Elliott, Paul Richard Mazanec
  • Publication number: 20240100344
    Abstract: Electrostimulating waveforms offering simultaneous and controllable cell-type-specific entrainment are described. The waveforms selectively entrain excitatory versus inhibitory cortical and hippocampal neurons including pyramidal neurons, parvalbumin neurons, and somatostatin neurons. The embodiment provides targeted electrical stimulation (ES) entrainment of excitatory versus inhibitory neurons. For example, the current disclosure provides methods of selectively entraining excitatory neurons with ES frequencies below 30 Hertz (Hz) and in particular embodiments to frequencies below 15 Hz, such as 8 Hz and 4 Hz. The current disclosure also provides methods of selectively entraining inhibitory neurons to ES frequencies of at least 30 Hz and depending on the type of inhibitory neuron, utilizing a frequency that is 30-60 Hz or a frequency that is greater than 100 Hz.
    Type: Application
    Filed: December 2, 2021
    Publication date: March 28, 2024
    Applicant: Allen Institute
    Inventors: Constantinos Anastassiou, Soo Yeun Lee
  • Publication number: 20240100345
    Abstract: A method of inserting and affixing an implant by making an incision in an abdominal wall is disclosed. A subcutaneous pocket is formed between a first layer of the abdominal wall and a second layer of the abdominal wall, such that the pocket is at least 2 centimeters from the costal margin. An implant is placed into the subcutaneous pocked and affixed within the subcutaneous pocket in the abdominal wall.
    Type: Application
    Filed: December 15, 2021
    Publication date: March 28, 2024
    Inventor: Eric Irwin
  • Publication number: 20240100346
    Abstract: A device for defibrillation and monitoring, a monitoring component, and a component for defibrillation and monitoring, are disclosed. The device for defibrillation and monitoring includes a host and a monitoring apparatus, which are assembled and disassembled through a detachably connection. The host is capable of independently performing defibrillation operations and display defibrillation information at least. Therefore, when it is necessary to go out for defibrillation operation alone, only the host is carried to medical assistance facilities. This monitoring apparatus can independently implement monitoring functions. When it is necessary to go out for implementing separate monitoring operations, just the monitoring apparatus is carried to the medical assistance facilities. Therefore, the user flexibly selects the devices they carry according to their requirements, improving the convenience of use.
    Type: Application
    Filed: September 26, 2023
    Publication date: March 28, 2024
    Applicant: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.
    Inventors: Lijuan HE, Huan ZOU, Dabing CHEN, Jianfeng JIANG, Peng ZHANG
  • Publication number: 20240100347
    Abstract: An example method is performed by a first medical device and includes generating first data indicating a physiological parameter of a subject; generating a filter configured to remove an artifact associated with a treatment; and generating second data by applying the filter to the first data. The example method further includes determining that a second medical device is administering the treatment to the subject. In response to determining that the second medical device is administering the treatment to the subject, the first medical device outputs an indication that filtering is available; receives an input signal selecting the filtering; and in response to receiving the input signal, displays the second data.
    Type: Application
    Filed: September 26, 2023
    Publication date: March 28, 2024
    Applicant: Stryker Corporation
    Inventors: Doan Huu Dinh, Tyson G. Taylor
  • Publication number: 20240100348
    Abstract: An ambulatory medical device capable of delivering therapy to a patient is provided. The ambulatory medical device comprises at least one controller operatively connected to at least one sensor configured to detect a health disorder of the patient, at least one treatment element configured to deliver therapy to the patient, and at least one response mechanism configured to be actuated by the patient, the at least one response mechanism having one of a first state and a second state. The at least one controller being configured to delay delivery of the therapy to patient for a first predetermined period of time responsive to detection of the health disorder and the at least one response mechanism having the first state, and to deliver the therapy to the patient in response to continued detection of the health disorder, the at least one response mechanism remaining in the first state.
    Type: Application
    Filed: December 12, 2023
    Publication date: March 28, 2024
    Inventors: Thomas E. Kaib, Marshal W. Linder
  • Publication number: 20240100349
    Abstract: A method of treating a heart, the method including providing an Implantable Pulse Generator (IPG) adapted to provide a combination of at least two treatment modalities including Cardiac Contractility Modulation therapy and one more modality selected from a group consisting of Cardiac pacing, Cardioversion, Defibrillation, Cardioversion and Defibrillation, and Cardiac Resynchronization Therapy (CRT), detecting a patient's physical condition, and selecting a combination of Cardiac Contractility Modulation therapy and at least one treatment modality from the group, and providing the combination of the Cardiac Contractility Modulation therapy and the at least one treatment modality. Related apparatus and methods are also described.
    Type: Application
    Filed: December 13, 2021
    Publication date: March 28, 2024
    Applicant: IMPULSE DYNAMICS NV
    Inventors: David PRUTCHI, Jason MEYERS, Tamir BEN DAVID
  • Publication number: 20240100350
    Abstract: The present invention relates to a step-up converter with a plurality of levels, in particular for use in an implantable medical device, comprising a transformer (11) comprising a single primary winding and a single secondary winding; a primary circuit (6) comprising the single primary winding; and a secondary circuit (7) comprising the single secondary winding and a plurality of step-up levels, each of the step-up levels comprising a first diode (4a, 4b, 4c, 4d, 4e, 4f) and a second diode (10a, 10b, 10c, 10d, 10e, 10f) and a first capacitor (9a, 9b, 9c, 9d, 9e, 9f) and a second capacitor (3a, 3b, 3c, 3d, 3e, 3f), wherein the first capacitors (9a, 9b, 9c, 9d, 9e, 9f) of the plurality of step-up levels are connected in series or in parallel with one another.
    Type: Application
    Filed: December 13, 2021
    Publication date: March 28, 2024
    Inventors: JEAN-CLAUDE BIERG, MARC LAFLUTTE, PAUL GIRAUD, EMMANUEL BÉGUIN
  • Publication number: 20240100351
    Abstract: A method for scoring and reporting electroencephalogram (EEG) data for use in transcranial magnetic stimulation (TMS) therapy. The method may include removing artifacts from the EEG data and determining EEG metrics from the EEG data. The method may further include determining a Brain Synchrony Index from the EEG metrics by applying a predetermined transfer function to the EEG metrics, and reporting the Brain Synchrony Index graphically.
    Type: Application
    Filed: September 28, 2023
    Publication date: March 28, 2024
    Inventors: James William Phillips, Alexander Joseph Ring
  • Publication number: 20240100352
    Abstract: A phototherapy device includes a base, at least one light conversion device and a light source module. The base has an installation slot. The light conversion device is detachably arranged in the installation slot. Each light conversion device includes a plurality of light conversion patterns. The light source module is arranged on a side of the base and configured to provide an excitation beam to the light conversion patterns, so that each of the light conversion patterns emits a converted beam. In this way, the light conversion device of the phototherapy device can be replaced according to the user's needs.
    Type: Application
    Filed: September 19, 2023
    Publication date: March 28, 2024
    Inventors: CHUNG-JEN OU, YU-MIN CHEN, MING-WEI TSAI, CHIEN-CHIH CHEN
  • Publication number: 20240100353
    Abstract: A light therapy device for treating a user's skin (such as wrinkles or acne). The device comprises a neckband for wearing on the user's neck and a light-emitting appliance comprising light diodes for delivering light therapy. Example formats for the light-emitting appliance include facemasks, eyemasks, and helmets. The device further comprises a power supply that may be contained within the neckband or carried by the neckband. An external electrical wire is for connecting the light-emitting appliance to the power supply. The neckband could have a variety of different configurations. Also disclosed are skin therapy kits and methods for light therapy to a user's skin.
    Type: Application
    Filed: September 22, 2023
    Publication date: March 28, 2024
    Inventors: Steven Yu, Jianheng Dong
  • Publication number: 20240100354
    Abstract: This disclosure relates to methods for modulating activity of cells and tissue with materials that are capable of being activated by light, such methods useful for treating diseases. The disclosure also provides devices and systems suitable for use in such methods, particularly devices and systems having oxygen plasma-treated p-type (boron) silicon.
    Type: Application
    Filed: October 16, 2020
    Publication date: March 28, 2024
    Inventors: Bozhi Tian, Menahem Rotenberg, Aleksander Prominski
  • Publication number: 20240100355
    Abstract: A laser therapy device comprising a pulsed laser light source. Each triggering of tissue irradiation causes application of a first heating laser pulse of a first power and a first pulse duration and at least a second heating laser pulse of a second power and a second pulse duration to the tissue. Changes in volume resulting from the rising and the decreasing power gradient of the first laser pulse are detected. The therapy device, on the basis of the measured values relative to the change in volume and taking into consideration at least the predetermined rises of the power gradients of the first heating laser pulse, determines an estimated value for the temperature increase in the tissue during irradiation of the first heating laser pulse, and generates, from the estimated value, a command that causes adjustment of the second power and/or the second pulse duration of the second laser pulse.
    Type: Application
    Filed: February 4, 2022
    Publication date: March 28, 2024
    Inventors: Eric SEIFERT, Ralf BRINKMANN, Hossameldin ABBAS
  • Publication number: 20240100356
    Abstract: A customized template and method create a template that is customized for a particular patient based on a treatment plan of the patient to perform a brachytherapy treatment.
    Type: Application
    Filed: December 7, 2023
    Publication date: March 28, 2024
    Applicant: Cowles Ventures, LLC
    Inventors: Emily Lin, Byron Stuck, Kevin Kelley
  • Publication number: 20240100357
    Abstract: A control circuit configured as a multi-criteria optimizer generates a radiation therapy treatment plan. The circuit then determines a resultant dose distribution as a function of the radiation therapy treatment plan and presents, on a display, at least a part of that resultant dose distribution. The latter may comprise, for example, presenting at least one isodose line on the display. The control circuit then detects user manipulation of a user interface. By one approach, this manipulation does not include corresponding immediate movement of any part of the presented resultant dose distribution itself. In particular, the detected user manipulation does not result in dragged movement of an isodose line on the display.
    Type: Application
    Filed: September 27, 2022
    Publication date: March 28, 2024
    Inventors: Jani Kurki, Matti Kemppainen, Laura Korhonen, Veli-Pekka Kihniä, Lauri Halko, Jarmo Makkonen, Pekka Sorvari
  • Publication number: 20240100358
    Abstract: A control circuit accesses a memory having stored therein a plurality of hierarchically-diversified radiation treatment planning templates. These templates include at least a first radiation treatment planning template that specifies radiation treatment planning information at a first hierarchical level. These templates also include at least a second radiation treatment planning template that specifies radiation treatment planning information at a second hierarchical level, wherein the second hierarchical level is more granular than the first hierarchical level. By one approach, the control circuit may access a plurality of differing ones of the second radiation treatment planning templates wherein each such template specifies radiation treatment planning information at the second hierarchical level.
    Type: Application
    Filed: September 28, 2022
    Publication date: March 28, 2024
    Inventors: Jarkko Y. Peltola, Esa Kuusela
  • Publication number: 20240100359
    Abstract: Provided is a method for estimating a total scatter factor in dose calculation for radiotherapy, wherein a linear accelerator, LINAC, is used to irradiate a medium. This method includes receiving geometric data of the LINAC, wherein the geometric data comprises geometric information about collimating devices of a LINAC head of the LINAC. The method further includes determining a head scatter factor based on a geometric head model using the received geometric data, wherein the head scatter factor quantifies a scatter contribution from the LINAC head, and determining a phantom scatter factor based on an empiric phantom scatter formula using the received geometric data, wherein the phantom scatter factor quantifies a scatter contribution from the irradiated medium. The method provides for determining an estimated total scatter factor using the determined head scatter factor and the determined phantom scatter factor.
    Type: Application
    Filed: March 30, 2021
    Publication date: March 28, 2024
    Inventor: Philipp PLEWA
  • Publication number: 20240100360
    Abstract: A control circuit accesses computed tomography images for a given patient and also accesses at least one image that includes an image of an artificial portion of the given patient. The control circuit then ascribes a density value to the artificial portion of the given patient and optimizes a radiation treatment plan for that given patient as a function of the computed tomography images, the image of the artificial portion of the given patient, and the density value ascribed to the artificial portion of the given patient to provide a resultant optimized radiation treatment plan.
    Type: Application
    Filed: September 28, 2022
    Publication date: March 28, 2024
    Inventor: Esa Kuusela
  • Publication number: 20240100361
    Abstract: Methods for treating tumors by administering FLASH radiation and a therapeutic agent to a patient with cancer are disclosed. The methods provide the dual benefits of anti-tumor efficacy plus normal tissue protection when combining therapeutic agents with FLASH radiation to treat cancer patients. The methods described herein also allow for the classification of patients into groups for receiving optimized radiation treatment in combination with a therapeutic agent based on patient-specific biomarker signatures. Also provided are radiation treatment planning methods and systems incorporating FLASH radiation and therapeutic agents.
    Type: Application
    Filed: August 24, 2023
    Publication date: March 28, 2024
    Applicant: Varian Medical Systems, Inc.
    Inventors: Renate PARRY, Eric ABEL, Swati GIRDHANI, Stanley MANSFIELD, Patrick KUPELIAN, Deepak KHUNTIA
  • Publication number: 20240100362
    Abstract: The accuracy charged-particle beam trajectories used for radiation therapy in patients is improved by providing feedback on the beam location within a patient's body or a quality assurance phantom. Particle beams impinge on a patient or phantom in an arrangement designed to deliver radiation dose to a tumor, while avoiding as much normal tissue as can be achieved. By placing fiducial markers in the tumor or phantom that contain specific atomic constituents, a detection signal consisting of atomic fluorescence is produced by the particle beam. An algorithm can combine the detected fluorescence signal with the known location of the fiducial markers to determine the location of the particle beam in the patient or phantom.
    Type: Application
    Filed: December 7, 2023
    Publication date: March 28, 2024
    Inventor: Brian P. Tonner
  • Publication number: 20240100363
    Abstract: Methods, systems and computer-readable media for controlling a radiotherapy apparatus are disclosed. A method for controlling a radiotherapy apparatus comprises obtaining a first treatment plan comprising positioning information of a beam shaping apparatus of the radiotherapy apparatus; receiving, during delivery of a radiation therapeutic beam to a target on a patient, information including a positional shift of the target; and generating a revised treatment plan based on the first treatment plan, the generating of the revised treatment plan comprising determining an updated configuration of the beam shaping apparatus from the positioning information of the first treatment plan based on the positional shift of the target.
    Type: Application
    Filed: September 28, 2022
    Publication date: March 28, 2024
    Inventor: Igor Sinitsyn
  • Publication number: 20240100364
    Abstract: Timing-based methods, systems, and computer readable mediums for a gated linear accelerator include synchronising a local clock of the linear accelerator with a clock of a patient monitoring system, determining latencies within one or more MR-gated radiotherapy processes and implementing latency based interlocks.
    Type: Application
    Filed: September 28, 2023
    Publication date: March 28, 2024
    Inventors: Christopher Knox, Joshua Freedman, Kevin John Brown, David Roberts
  • Publication number: 20240100365
    Abstract: A method for monitoring a hadron beam during hadron-therapy treatment of a subject including tumour cells labelled with a radiopharmaceutical product, in which the hadron beam includes a plurality of discrete hadron bursts, the method including the following steps: when a burst impacts on the subject, detecting the prompt gamma generated by the interaction of the hadrons of the burst with the tissues of the subject using a Compton telescope and reconstructing an image of the interaction volume; when no burst impacts on the subject, extracting the position of the tumour cells labelled with the radiopharmaceutical product using the Compton telescope and reconstructing an image of the total volume of the tumour; comparing the image of the interaction volume and the image of the total volume of the tumour so as to locate the measured interaction volume relative to the measured total volume of the tumour.
    Type: Application
    Filed: October 16, 2020
    Publication date: March 28, 2024
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT MINES TÉLÉCOM
    Inventors: Dominique THERS, Jean-Sébastien STUTZMANN
  • Publication number: 20240100366
    Abstract: Systems, methods, and computer-readable media for enabling ultraviolet radiation treatments are provided.
    Type: Application
    Filed: June 2, 2023
    Publication date: March 28, 2024
    Inventors: Marigdalia Kaleth Ramirez-Fort, Migdalia Fort
  • Publication number: 20240100367
    Abstract: A radiation therapy system may include a magnetic resonance imaging (MRI) device configured to acquire MRI data with respect to a region of interest (ROI). The MRI device may include a main magnet that is around a longitudinal axis and configured to generate a magnetic field. The MRI device may also include a radiation therapy device configured to perform a treatment on at least one portion of the ROI by delivering, based on the MRI data, therapeutic radiation to the at least one portion of the ROI. The radiation therapy device may be rotatable around the longitudinal axis. The MRI device may also include a first shielding structure configured to provide interference shielding for the MRI device or the radiation therapy device. The radiation therapy device may be rotatable relative to the first shielding structure around the longitudinal axis.
    Type: Application
    Filed: December 7, 2023
    Publication date: March 28, 2024
    Applicant: SHANGHAI UNITED IMAGING HEALTHCARE CO., LTD.
    Inventors: Shuguang LIU, Cheng NI, Peng WANG, Jianfeng LIU, Jian ZHANG, Yuelin SHAO
  • Publication number: 20240100368
    Abstract: A face mask assembly configured with a drop down feature and a method of manufacturing the same are provided. The face mask assembly includes a face mask component slidable along a length of at least a first strap. The face mask component includes a first dynamic strap engagement feature defining a slide portion and a locking portion to engage the first strap. The slide portion includes a smooth edge such that the face mask component is slidable along the length of the first strap while the first strap is positioned within the slide portion. The locking portion includes a sharp edge to provide frictional restriction to the first strap during operation such that face mask component is locked relative to the length of the first strap while the first strap is positioned within the locking portion. A corresponding method of manufacture is also provided.
    Type: Application
    Filed: December 4, 2023
    Publication date: March 28, 2024
    Inventors: Oliver Gomez Rodriguez, Rodrigo Marin Barroeta, Edgar Ricardo Bautista Lopez, Tanguy Prevot, Joseph Rodrigues, Marie Hammer
  • Publication number: 20240100369
    Abstract: Provided are an electronic mask and a method of controlling the electronic mask. The electronic mask includes at least one filter; at least one sensor configured to obtain sensing data related to the at least one filter; a fan configured to generate a flow of air toward the at least one filter; and at least one processor configured to: identify a grade of the at least one filter based on the sensing data obtained from the at least one sensor, and control a rotation speed of the fan based on the grade of the at least one filter.
    Type: Application
    Filed: July 18, 2023
    Publication date: March 28, 2024
    Applicant: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Sungkoo Cho, Mukyong Kim, Mijo Kang, Kyungah Chang
  • Publication number: 20240100370
    Abstract: A facemask assembly including a framework and front clip and method of manufacturing the same where a filter material is inwardly folded over a back frame creating an expanded breathable filter surface area; and, a front clip with slot construct adapted for insertion of one or more of straps, cords, tubing and o-rings has a cell construct at the top of the post forming a quadrilateral cell from which the surrounding cell construct has one or more perpendicular members extending to one or more clips adapted to fit over a back frame. The filter material is cut and a facial sealing strip with conformal straps are bonded to the rim of the facemask.
    Type: Application
    Filed: December 11, 2023
    Publication date: March 28, 2024
    Inventor: Steve Waterford