Abstract: A method for supplying insufflation fluid to a patient cavity includes positioning a secondary trocar at least partially within a primary trocar, the secondary trocar being configured to facilitate delivery of insufflation fluid to a patient cavity. The method further includes, upon positioning the secondary trocar at least partially within the primary trocar, coupling the secondary trocar to the primary trocar thereby forming a trocar assembly. The method further includes coupling the primary trocar to a surgical robot and delivering the insufflation fluid to the patient cavity using the trocar assembly.

Abstract: An activation mechanism for an aerosol dispenser is presented having a first housing structure, an actuation member movably arranged in the first housing structure, wherein the first housing structure is provided with an actuation member opening in level with the axial position of the actuation member, and an activation member slidably attached to the first housing structure, the activation member slides between a non-triggering position and a triggering position relative to the first housing structure, wherein the activation member has a radially flexible tab portion that is offset from the actuation member opening when the activation member is in the non-triggering position, restricting radial flexing of the tab portion, and wherein the tab portion aligns with the actuation member opening when the activation member is in the triggering position, thereby enabling the tab portion to flex radially inwards to cause movement of the actuation member.

Abstract: A breath actuated metered dose inhaler may comprise a canister fire system configured to fire a medicament containing canister in response to patient inhalation. The canister fire system may comprise a pneumatic force holding unit and having a rest configuration in which a metering valve of the canister is in a refill configuration; a prepared configuration in which a canister actuation force is retained by the pneumatic force holding unit and the canister fire system is actuatable by patient inhalation induced airflow; and a fire configuration in which the metering valve is in a dose delivery position. When in the prepared configuration, the force retained by the pneumatic force holding unit may be reduced by less than about 6% over a period of 5 minutes, preferably less than about 3% over a period of 5 minutes.

Abstract: An electronic vapor provision system includes a vaporizer for vaporizing a payload for inhalation by a user of the electronic vapor provision system, the vaporizer taking a finite period of time from having power supplied to it to vaporize the payload; a power supply for supplying power to the vaporizer to vaporize the payload in response to a user activation; one or more sensors operable to output respective signals in response to interaction of the user with the electronic vapor provision system; an estimation processor configured to estimate a user's expected moment of activation, based upon analysis of one or more of the respective signals; and a control processor configured to cause power to be supplied to the vaporizer at a time that precedes the user's estimated expected moment of activation.

Abstract: The present disclosure relates to a heating inhaler and a controlling method thereof. The method includes: the sensing element detecting a suction action, and if the sensing element detects the suction action within a first predetermined time period, the control circuit board controlling the power source to supply power to the atomizer for a second predetermined time period then stop supplying, wherein the indicating element displays a first state within the second predetermined time period until the power source stops supplying power to the atomizer, then the indicating element displays a second state. If the sensing element detects no suction action within the first predetermined time period, the control circuit board controlling the power source to stop supplying the electric power to the atomizer, and the indicating element displaying the second state.

Abstract: An exchanger conduit permits temperature and/or humidity conditioning of a gas for a patient respiratory interface. In an example embodiment, a conduit has a first channel and a second channel where the first channel is configured to conduct an inspiratory gas and the second channel configured to conduct an expiratory gas. An exchanger is positioned along the first channel and the second channel to separate the first channel and the second channel. The exchanger is configured to transfer a component (e.g., temperature or humidity) of the gas of the second channel to the gas of the first channel. In some embodiments, an optional flow resistor may be implemented to permit venting at pressures above atmospheric pressure so as to allow pressure stenting of a patient respiratory system without a substantial direct flow from a flow generator of respiratory treatment apparatus to the patient during patient expiration.

Abstract: An automated drug delivery and monitoring system for use on mechanically ventilated patients in the intensive care unit is presented. Medication in the form of respirable particles is transported through ventilator circuitry by a delivery unit. Multiple medications may be delivered into the gas flow of the ventilator, with each medication delivered in a defined dose for a frequency and interval as specified by an operator. The particles mixed into the gas flow of the ventilator are inhaled and ingested by the patent's lungs.

Abstract: A method is provided for reducing the risk of sustaining a traumatic brain injury caused by a traumatic event that includes identifying a subject at risk of sustaining a traumatic brain injury, and then precisely increasing the partial pressure of carbon-dioxide (CO2) in the blood of the subject (pCO2). This method can be applied to raise the CO2 and pCO2 to improve orthostatic hypotension in conditions such as dysautonomias (like Positional Orthostatic Tachycardic Syndrome POTS) and to facilitate the drive to breathe in conditions like Central Sleep Apnea (CSA) and Sudden Infant Death Syndrome (SIDS). The pCO2 of the person is increased by placing a breathing apparatus over the mouth of the person through which the person must breath, wherein the breathing apparatus includes an enlarged dead space volume in which expired CO2 collects to be inhaled or re-breathed by the person on the next inhalation.

Abstract: There is described a ventilator for ventilating an airway of a patient. The ventilator is generally configured to perform a series of respiration cycles, wherein each respiration cycle includes the delivery of a main volume of fresh respiratory gas into the patient's airway, followed by the evacuation of a corresponding volume of used respiratory gas, and to further perform a series of subcycles during a corresponding one of the respiration cycles, wherein each subcycle includes the delivery of an auxiliary volume of fresh respiratory gas into the patient's airway, followed by the evacuation of a corresponding volume of used respiratory gas, the auxiliary volume being smaller than, and distinct from, the main volume.

Abstract: An intubation assembly and shield configured to at least partially reduce the risk of contagion of airborne illnesses. The intubation assembly comprises an intubation apparatus assembly, which may comprise an intubation apparatus such as a laryngoscope, endoscope, bronchoscope, or other fiberoptic device. The intubation apparatus assembly may be operatively disposed on the shield assembly. The intubation apparatus may be placed on a correspondingly dimensioned sleeve. The shield assembly comprises a body with a plurality of side segments and a first transparent component with a shield opening disposed thereon. The shield opening may be used for insertion of the intubation apparatus assembly. The shield assembly may also comprise a second transparent component with at least one longitudinally disposed slot for insertion of an endotracheal tube or other intubation apparatus(es). The shield assembly may be provided with ports to attach a vacuum device to provide negative pressure.

Abstract: A device combining a treatment of ear and sinus conditions along with speech therapy and administration of medication is disclosed. The device comprises a patient facemask, adapted to cover mouth and nose of a patient, and a visual and/or audio feedback mechanism connected to the facemask and adapted to provide feedback through internal air pressure in a device's compartment. The device's compartment is adapted to be in fluid communication with the patient mouth and nose during its operation. The device may comprise a supervisor facemask. Expiration into the facemask(s) increases air pressure. An increase in air pressure within the device activates the feedback mechanism and will lead to effective middle ear and sinus ventilation. The feedback mechanism may also be used in speech therapy for feedback to the patient. Drugs may be administered into the system for treatment of airway disease of for the purpose or general anaesthesia.

Abstract: A mask for the delivery of a medical gas under positive pressure. The engagement surface is generally circular in shape and is sufficiently rigid that operatively, when a suitable retention force is applied to the mask, an effective seal is produced at the interface of the engagement surface and the surrounding tissue primarily by deformation of the surrounding tissue.

Abstract: A patient interface for delivering breathable gas to a patient includes a sealing portion including a nose tip engagement portion adapted to form a seal with the patient's nose tip, an upper lip engagement portion adapted to form a seal with the patient's upper lip and/or base of the patient's nares, and nostril engagement flaps adapted to form a seal with the patient's nares. The nose tip engagement portion, the upper lip engagement portion, and the nostril engagement flaps are all structured to extend or curve outwardly from a supporting wall defining an air path.

Abstract: A connector for connecting with an absorber canister includes a first connection port for detachably communicating with an input port of the absorber canister; a second connection port for detachably communicating with an output port of the absorber canister; and a seal. The seal being sleeved on a sidewall of at least one connection port of the first connection port and the second connection port, and the seal including: an annular ring positioned on an outer sidewall of the at least one connection port; a guide chamfer portion, the guide chamfer portion being annular and extending obliquely from a bottom of the annular ring towards an interior of the at least one connection port; and a lip, the lip being annular and extending from an end portion of the guide chamfer portion in a direction towards or away from the annular ring.

Abstract: The present invention provides for an improved method of determining a water out condition in a humidified gases supply apparatus. The method includes a two step process including a primary determination of a water out condition and a secondary determination of a water out condition. This primary determination is made during observation of the normal operation of the apparatus. During the secondary determination the method takes temporary control over the humidifying part of the apparatus. The secondary determination confirms or contradicts the primary determination.

Abstract: Catheters include first and second segments that each include a proximal end and a distal end. A first connector of each catheter includes a first portion connected to the distal end of the first segment and a second portion connected to the proximal end of the second segment. The first portion and the second portion are engaged so that the first portion can rotated relative to the second portion about an axis of the first connector. The first segment and the second segment can bend in multiple planes via a rotation of the first portion relative to the second portion about the axis.

Abstract: The invention resides in the field of introducing fluid pumps into a lumen and relates to a system for introducing a pump into a lumen which comprises a first sheath and a pump to be introduced into the first sheath, or a system which has a pump with a distal pump unit and a shaft catheter which emerges proximally to the pump unit. According to the invention one or two sheaths are used, the distal pump unit being pulled firstly into the distal end of one sheath, in order to avoid damage to a shaft catheter. Subsequently, the sheath receiving the pump unit is transferred into a further sheath or a receiving lumen.

Abstract: A deflectable catheter shaft with compression resistance coils configured to create different curve shapes when the catheter is steered or deflected in different directions. One or more compression resistance coils may include an elongated-pitch section. The compression resistance coils may be pull wire compression coils or body compression coils.

Abstract: A method of making magnetically controllable devices for interventional medical procedures comprises the steps of: Manufacturing a medical device for interventional medical procedures having magnetic materials which are without permanent magnetization; and establishing permanent magnetization within the magnetic materials subsequent to manufacturing, wherein the permanent magnetization allows the medical device to be magnetically controllable. The method may further including the step of packaging and sterilizing the medical device, wherein establishing permanent magnetization occurs after packaging and sterilization. The establishing permanent magnetization within the magnetic materials may include providing different magnetic orientations to distinct portions of the magnetic materials. The magnetic material includes one of a platinum alloy or a palladium alloy.

Abstract: The invention relates to a puncturing system comprising an outer tubular body which is designed to remain in a body part of a living being, characterized in that the puncturing system has at least one inner tubular body and a puncturing needle, wherein the inner tubular body is guided through a working lumen of the outer tubular body and can be longitudinally displaced with respect to the outer tubular body, and the puncturing needle is guided through a puncture lumen of the inner tubular body and the inner tubular body can be longitudinally displaced with respect to the puncturing needle, wherein, after a body part has been punctured by means of a puncturing section of the puncturing needle, which protrudes out of a patient-side end of the puncturing system, the inner tubular body can be moved out of the patient-side end of the catheter at least partially out of the outer tubular body, and is thereby designed to accommodate the puncturing section of the puncturing needle, which protrudes out of the patient-s

Abstract: Needle assemblies and related methods in which a valve opener is used to push into a valve to open one or more slits on the valve to open the valve. The needle assemblies each includes a needle hub with a needle, a catheter tube with a catheter hub and the valve and valve opener positioned in the interior cavity of the catheter hub. The valve can have a valve skirt and a nose section of the valve opener can locate therein. One or more reliefs can be provided with the valve opener so that an elbow or diagonal section on a needle guard can project from a holding space within the valve opener through the relief.

Abstract: A catheter for guiding a body fluid of a subject includes an elongated body, an adjusting mechanism, and a valve mechanism. Moreover, the elongated body further includes a first portion, a second portion and a flexible portion between the first and the second portions. The second portion includes a passageway for the body liquid. The valve mechanism closes to the inlet of the passageway. Furthermore, the flexible portion expands when the adjusting mechanism is in a first state to prevent the catheter from being removed from the subject, and the flexible portion retracts when the adjusting mechanism alters to a second state to allow the catheter to be removed from or inserted into the subject. Hence, the body fluid is directed to enter the passageway via the inlet and exit via the outlet when the adjusting mechanism is not in the second state.

Abstract: A balloon catheter has a central tube that is configured to both structurally support and inflate a balloon membrane. The central tube has a lumen and sidewall inflation ports that provide a path for inflating the balloon. The lumen of the central tube is obstructed by a distal end piece, nose piece, or other structure to prevent fluid from exiting a distal end of the central tube. The central tube is configured such that, during inflation, inflation media is allowed to pass through an elongated shaft of the catheter, into a proximal open end of the central tube, and through the inflation ports into the balloon. The central tube can slide longitudinally in relation to the shaft to longitudinally elongate and/or truncate the balloon.

Abstract: Various embodiments disclosed relate to drug-coated balloon catheters for treating, preventing, or reducing the recurrence of a stricture and/or cancer, or for treating benign prostatic hyperplasia (BPH), in a non-vascular body lumen and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent. In some embodiments, the balloon catheter includes a length-control mechanism which stretches and elongates the balloon when it is in a deflated state, giving the balloon a smaller cross-sectional deflated profile for tracking through the body lumen and for removal after treatment.

Abstract: MVO is treated by introducing injectate into blood vessels affected by MVO at precise flow rates, while blocking retrograde flow, such that the natural pumping of the heart aids in forcing the injectate into the affected microvessels. Monitoring pressure distal of an occlusion balloon is used to determine treatment effectiveness and heart health.

Abstract: A balloon guide catheter including a catheter shaft having a main lumen defined therein extending axially therethrough to receive a guidewire therein and an inflation lumen defined axially therein arranged semi-encircling the main lumen. The inflation lumen having an inlet port radially outward from the catheter shaft and an exhaust vent(s) disposed proximate the distal end of the catheter shaft. The exhaust vent(s) being disposed longitudinally through a distal terminating end of the inflation lumen or radially inward in fluid communication with the main lumen. A porous membrane is disposed at the exhaust vent(s) to permit only gas to pass therethrough. Secured about the outer surface proximate the distal end of the catheter shaft and coinciding with the inlet port is a balloon.

Abstract: A balloon catheter device with a fluid management system includes a source of balloon fill media and a balloon catheter in fluid communication with the source of balloon fill media. A first conduit is provided for delivering the balloon fill media from the source to the balloon catheter for inflation of a balloon of the catheter device. A second conduit is provided for returning the balloon fill media from the balloon catheter to the source for deflating the balloon. A first pump is disposed along one of the first conduit and the second conduit for pumping the balloon fill media through the respective conduits.

Abstract: A process for arranging a protective sheath on a drug-coated balloon catheter in a machine. The protective sheath is transported via a transport system into a holding device. A drug coated area of the balloon catheter from contact with the machine. The protective sheath is arranged on a drug-coated area of the balloon catheter by machine relative motion between the balloon catheter and the protective sheath. The protecting can be placing at least one first and one second flexible film between the balloon catheter and a guide of the machine during the relative motion or can be holding the balloon catheter at a position on the catheter away from the drug-coated area during the relative motion.

Abstract: A wound therapy system includes a dressing an instillation pump fluidly communicable with the dressing and configured to provide instillation fluid to the dressing, a negative pressure pump fluidly communicable with the dressing and configured to remove air from the dressing, and a control circuit communicably coupled to the instillation pump and the negative pressure pump. The control circuit is configured to control the instillation pump to provide an amount of the instillation fluid to the dressing, provide a soak period, and control the negative pressure pump to provide a cyclic variation of negative pressure at the dressing.

Abstract: A medical device that may include an elongate member having a proximal end and a distal end, and a lumen disposed through the elongate member is disclosed. The medical device may also include an opening disposed at the distal end of the elongate member in communication with the lumen, and a pushing element disposed with the lumen. The medical device may also include at least one fiducial disposed within the lumen and distal to the pushing element, and a separating mechanism disposed at the distal end of the elongate member. The separating mechanism may be configured to apply a separating force to deploy the at least one fiducial.

Abstract: A wirelessly powered tattoo machine is disclosed, which has a substantially radially symmetric exterior shape for optimal manipulability by a user, and integrated controls for on-device configuration and operation. The power supply component of the machine may be removed, and multiple battery packs may be utilized with a single machine for continuous use. The machine may also be powered by wire and simultaneously operate the machine while charging a connected battery pack. The machine may further include wireless communication with one or more separate devices to operate the machine or control the machine's settings, such as a foot pedal or mobile phone.

Abstract: An apparatus for providing instrument access through a gel pad of a surgical access device disposed to seal an opening to a body cavity of a patient is disclosed. The apparatus includes a stem having a bore extending therethrough, the stem having a length sufficient such that when the stem is inserted through the gel pad a distal end of the stem protrudes beyond an inner surface of the gel pad. The bore is sized to permit an instrument to be inserted through the bore and through the opening into the body cavity. The stem includes a flanged opening to the bore that remains external to an outer surface of the gel pad and limits the insertion of the stem through the gel pad. The apparatus also includes a displaceable seal disposed within the bore below the flanged opening, the displaceable seal being operable to seal the bore prior to insertion of the instrument and to displace to permit insertion of the instrument while maintaining the seal.

Abstract: A connector is disclosed that includes comprising a body having a tubing portion, a luer portion axially opposite the tubing portion and connected thereto, and an inner circumferential surface defining an internal bore of the connector. The inner circumferential surface extends axially between the tubing portion and the luer portion, and the internal bore being is in fluid communication with the tubing portion and the luer portion. The inner circumferential surface includes a plurality of splines extending axially along a length of the inner circumferential surface in the tubing portion of the connector. The inner circumferential surface is configured to engage an external surface of a tubing in a coupled configuration. In the coupled configuration edges of the splines grip and engage the external surface of the tubing to retain the tubing in the body.

Abstract: An exemplary pharmaceutical compounding system and device for mixing materials from at least two distinct material sources can include a transfer set and junction structure that has a junction body, a first inlet port located at a first portion of the junction body, a second inlet port located at a second portion of the junction body, and an outlet port located at a third portion of the junction body. The junction structure can be configured to mix fluid received from both the first inlet port and second inlet port and to deliver the fluid to the outlet port. The junction structure can also include attachment structure located on the junction body and configured to attach the junction structure to the housing of the compounding device at a location downstream of a pump system.

Abstract: A device for clamping and holding medical hose lines includes a hose clamp with two clamping legs on opposite sides of a passage. The passage is configured to receive a first hose portion. The clamping legs are movable between a clamping position, in which the clamping legs constrict the passage and clamp the first hose portion, and a release position in which the constriction is eliminated. The device also includes a holding clip connected to the hose clamp. The holding clip has two arms arranged opposite one another bordering a recess. The recess is configured to receive at least one second hose portion to be held between the arms. The arms are movable relative to one another between an open position, in which the arms expose a slot opening radially into the recess, and a holding position in which the slot is closed or at least constricted.

Abstract: A blinding cap for covering a needle shield that is covering a needle of a syringe includes an elongated body extending between a proximal end and an opposing distal end, the body at least partially bounding a chamber. An annular sleeve projects from the proximal end of the body and at least partially bounds a channel. A first flange radially inwardly projects from the body into the chamber, the first flange at least partially bounding an opening that provides communication between the chamber and the channel.

Abstract: A syringe stabilizing apparatus has a base and a syringe support. The syringe support is vertically disposed above the base, elevating a fluid-filled portion of an infusion set vertically above the base and orienting a delivery end of the fluid-filled portion upwardly relative to a horizontal plane to take advantage of a gravitational effect on a fluid during delivery of the fluid from the fluid-filled portion to a patient. The syringe support comprises a first retainer and a selectively actuated tube clamp. The first retainer has an opening in which a rigid portion of the infusion set is received and retained therein without further user intervention. The selectively actuated tube clamp is operatively aligned with the first retainer. A flexible tube extending from the rigid portion of the infusion set extends through the selectively actuated tube clamp.

Abstract: A system for transporting persons with reduced mobility includes a chassis having two lateral cross members, a device for connecting to an IV pole including a rod and a wheeled support attached to an end of the rod, the connection device including an attachment support fixed to the chassis, a coupling element designed to be solidly fixed to the rod, a member for connecting the coupling element to the attachment support, a lateral stop attached to at least one of the cross members, the lateral stop being built and arranged to brace the wheeled support in relation to the chassis and to position the IV pole laterally in relation to the transportation system.

Abstract: An infusion pump includes a housing, a wireless transceiver, a pump motor mounted within the housing, a location sensor configured to provide information associated with a location of the infusion pump, a battery conductively coupled to the wireless transceiver, the pump motor, the location sensor and processor(s), and memory. The infusion pump is configured to monitor, using the location sensor, a geofence parameter of the infusion pump, determine a change in the location of the infusion pump based on the geofence parameter, identify an operation mode of the infusion pump associated with the geofence parameter, and automatically switch, responsive to the changed location, the operation mode of the infusion pump from a first mode currently programmed for care of a patient to a second mode, the second mode using different parameters than the first mode to control elements of the infusion pump.

Abstract: The subject invention provides a drug delivery device for injecting medicament which includes a tubular reservoir; a stopper slidably disposed in the reservoir; a spring for moving the stopper in the reservoir; at least one needle, the needle having a distal end for insertion into a patient, and a lumen extending proximally from the distal end, the lumen being in direct or indirect communication with the reservoir; a needle driver for displacing the needle; and an actuator. Activation of the actuator causes the spring to move the stopper and the needle driver to displace the needle. The needle moves relative to, and separately from, the reservoir with the needle being displaced. Advantageously, with the subject invention, a drug delivery device is provided wherein a needle is moved, relative to the reservoir, in being displaced for injection. This permits control of the needle displacement separate from the reservoir.

Abstract: A medical device having an antimicrobial coating on a surface of the medical device and an inserter device for subcutaneously inserting the medical device. The inserter device includes an outer part having one or more locking elements including a first locking element and one or more release elements including a first release element; a housing; and a functional part accommodated in the housing. The housing includes a sidewall with an inner surface forming a cavity, the housing extending from a first end to a second end along a first axis and comprising one or more housing guide members including a first housing guide member for engagement with one or more guide members of the functional part. The functional part comprises a first part with a first body extending from a first end to a second end along the first axis.

Abstract: A valve for controlling delivery of fluid includes a valve seat comprising a fluid inlet, a fluid outlet, a well having a passage, and a valve membrane comprising a conical portion having a base and a tip. The conical portion is configured to fit within the passage of the valve seat. The valve membrane is configured to fluidly connect the fluid inlet to the fluid outlet when the valve membrane is in an undeformed position and fluidly disconnect the fluid inlet from the fluid outlet when the valve membrane is in a radially deformed position.

Abstract: A fluid extravasation detection device detects the subcutaneous extravasation of fluid from a vein containing an intravenous (IV) catheter. The device includes one or more first temperature sensors for positioning on skin near an entry point of the IV catheter into the vein, and one or more second temperature sensors for positioning on skin near a tip of the subcutaneously located IV catheter. The first and second temperature sensors are operably connected to an electronic thermometer that compares the temperature difference between a first temperature and a second temperature. The first temperature is determined based on temperature detected by at least one of the one or more first temperature sensors. The second temperature is determined based on temperature detected by at least one of the one or more second temperature sensors. An alarm is activated if the difference between the first and second temperatures changes more than a predetermined amount.

Abstract: Some embodiments an infusion pump system can be configured to modify alarm limit parameters as the user's insulin load increases or decreases. Moreover, in particular embodiments, the infusion pump system can be configured to provide a “missed bolus” or “missed meal” alarm in response to the user's blood glucose characteristics, the user's insulin load information, or the like.

Abstract: Disclosed are a device, system, methods and computer-readable medium products that provide an updated insulin-to-carbohydrate ratio and an updated total daily insulin. The described processes may be used for periodic updating of the insulin-to-carbohydrate ratio and the total daily insulin. The insulin-to-carbohydrate ratio and/or the total may be used in the calculation of new doses of insulin that a drug delivery device may be commanded to deliver to a user.

Abstract: An automated blood glucose control system is configured to generate a backup therapy protocol comprising insulin therapy instructions derived from autonomously determined doses of insulin. The system generates a dose control signal using a control algorithm configured to autonomously determine doses of insulin to be infused into a subject for the purpose of controlling blood glucose of the subject based at least in part on a glucose level signal received from a glucose sensor. The system can track insulin therapy administered to the subject over a tracking period, including storing an indication of the autonomously determined doses of insulin delivered to the subject as basal insulin, as correction boluses of insulin, or as mealtime boluses of insulin. The system can generate a backup injection therapy protocol or a backup pump therapy protocol with insulin therapy instructions based at least in part on the insulin therapy administered to the subject over the tracking period.

Abstract: Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, a controller module, and optionally a single point glucose monitor are provided. Integration may be manual, semi-automated and/or fully automated.

Abstract: The invention provides methods and apparatus for injecting a medicine, especially a highly viscous medicine. Conventional methods and apparatus for injecting viscous medicines suffers suffer from a variety of problems such as excessive force during the initial needle insertion and initial injection. In an inventive method, during the initial phase of the injection, energy is stored in a torsion spring that is subsequently released during a later stage of the injection. The present invention also provides for an improved autoinjector; especially via the use of a combination compression and torsion spring that powers the injection through controlling force applied to a plunger via a screw flange or nut having pins that ride in a prescribed path down the length of the autoinjector.

Abstract: An autoinjector includes a case configured to receive a syringe, a slidable member that is movable axially within the case to cause at least a portion of the syringe to move axially when the syringe is disposed within the case for dispensing a medicament through a needle of the syringe, a locking member configured to prevent actuation of the slidable member when the autoinjector is in a pre-dispense configuration, a sleeve coupled to a distal end of the case and surrounding at least a portion of a needle of the syringe when the syringe is disposed within the case, an elongate member extending proximally from the sleeve and configured to deflect the locking member to allow actuation of the plunger, and two drive springs coupled to the slidable member and configured to apply a biasing force that acts on the slidable member to move the slidable member distally.

Abstract: Disclosed herein is an auto injector for administering a medicament, the auto injector comprising: a housing; a cartridge receiver configured to receive a cartridge comprising a first stopper and a cartridge compartment containing the medicament, the cartridge compartment having a first cartridge subcompartment containing a first medicament component of the medicament and a second cartridge subcompartment containing a second medicament component of the medicament; a drive module coupled to move a plunger rod between a retracted plunger rod position and an extended plunger rod position, the plunger rod being configured to move the first stopper; a processing unit coupled to the drive module, wherein the processing unit is configured to control the drive module to move the plunger rod from a first plunger rod position to a mix plunger rod position with a mix plunger rod speed, wherein the mix plunger rod position is selected to position the first stopper in a position wherein the first medicament component is m