Patents Issued in April 16, 2024
  • Patent number: 11958788
    Abstract: The present invention discloses a method of preparing an alkali activation material by using red mud-based wet grinding and carbon sequestration and an application thereof. The preparation method includes: (1) adding water, red mud, a crystalline control agent, and a grinding aid into a wet grinding carbon sequestration apparatus to perform wet grinding, and simultaneously introducing CO2 until a slurry pH reaches 7 to 7.5; and removing wet grinding balls by a sieve to obtain a slurry A; (2) adding carbide slag, water and a water reducer to a wet planetary ball grinder tank for wet grinding, and removing wet grinding balls by a sieve to obtain a slurry B; (3) taking 50 to 80 parts of the slurry A and 20 to 50 parts of the slurry B and mixing them to obtain an alkali activation material.
    Type: Grant
    Filed: May 23, 2023
    Date of Patent: April 16, 2024
    Assignee: Hubei University Of Technology
    Inventors: Xingyang He, Weilong Li, Ying Su, Zhengqi Zheng, Jin Yang, Yingbin Wang, Hongbo Tan, Chenghao Li
  • Patent number: 11958789
    Abstract: A method for determining a consistency coefficient of a power-law cement grout includes: determining a water-cement ratio of the power-law cement grout; according to engineering practice requirements, determining a time required to determine the consistency coefficient of the power-law cement grout; and obtaining the consistency coefficient of the power-law cement grout. The method is accurate and reliable, requires less calculation, etc.; and has very high practical value and popularization value in environmental protection and ecological restoration.
    Type: Grant
    Filed: December 12, 2023
    Date of Patent: April 16, 2024
    Assignee: KUNMING UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Zhi-quan Yang, Jun-fan Xiong, Ying-yan Zhu, Yi Yang, Yong-shun Han, Muhammad Asif Khan, Jian-bin Xie, Tian-bing Xiang, Bi-hua Zhang, Han-hua Xu, Jie Zhang, Shen-zhang Liu, Qi-jun Jia, Cheng-yin Ye, Gang Li
  • Patent number: 11958790
    Abstract: The invention is directed to a co-layered propellant grain having an exposed outer surface, wherein said propellant grain comprises an outer layer comprising a slow burning propellant composition located on essentially the entire outer surface of the grain, and an inner layer comprising a fast burning propellant composition having a higher linear burn rate than said slow burning propellant composition; wherein said propellant grain has a structure such that after ignition, the inner layer becomes increasingly exposed at the outer surface.
    Type: Grant
    Filed: August 20, 2018
    Date of Patent: April 16, 2024
    Assignee: Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNO
    Inventors: Christoffel Adrianus Van Driel, Martijn Zebregs, Dinesh Ravindre Ramlal, Michiel Hannes Straathof
  • Patent number: 11958791
    Abstract: A method for separating butenes from C4 hydrocarbon streams containing butanes and butenes involves extractive distillation with a suitable solvent. The method also involves heat integration, which makes it possible to use the heat of the solvent in order to heat various streams.
    Type: Grant
    Filed: January 21, 2022
    Date of Patent: April 16, 2024
    Assignee: EVONIK OXENO GMBH & CO. KG
    Inventors: Philip Lutze, Stephan Peitz, Armin Matthias Rix, Tanita Valèrie Six, Moritz Schröder, Niklas Paul
  • Patent number: 11958792
    Abstract: The disclosure pertains to a urea production plant and process using a thermal stripper, wherein the reaction mixture is separated in two parts, wherein the first part is supplied at least in part to the thermal stripper and the second part at least in part bypasses the thermal stripper and is supplied to a medium pressure recovery section.
    Type: Grant
    Filed: August 10, 2023
    Date of Patent: April 16, 2024
    Assignee: Stamicarbon B.V.
    Inventor: Wilhelmus Hubertus Geurts
  • Patent number: 11958793
    Abstract: A urea production plant including a synthesis and recovery section has a first evaporation section connected with the synthesis and recovery section and a first condensation section. A granulation section is connected to the first evaporation section. A scrubbing section is connected to the granulation section. A second evaporation section is connected to the scrubbing section. The second evaporation section is connected to the granulation section. A second condensation section is connected to the second evaporation section. A quenching section includes a liquid inlet for the distribution of a quenching liquid is located and connected between the granulation section and the scrubbing section and the quenching section is connected to a quenching liquid providing section and the second condensation section.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: April 16, 2024
    Assignees: THYSSENKRUPP FERTILIZER TECHNOLOGY GMBH, thyssenkrupp AG
    Inventors: Harald Franzrahe, Axel Erben, Simon Koch
  • Patent number: 11958794
    Abstract: Integrated processes are disclosed for the catalytic conversion of carbohydrate to ethylene glycol and/or propylene glycol using a homogeneous, tungsten-containing retro-aldol catalyst. In these processes, the carbohydrate is subjected to retro-aldol conversion and hydrogenation to provide a reaction product containing ethylene glycol and/or propylene glycol, other reaction process including organic acids, itols and tungsten species. Ethylene glycol and propylene glycol are separated from the reaction product for purification, and at least a portion of the remaining fraction is subjected to ion exclusion chromatography to provide an eluant containing tungsten species and a subsequent eluant containing organic acids and a substantially reduced concentration of tungsten species. At least a portion of the eluant containing tungsten species can be recycled for reuse directly or with intervening unit operations to enhance the catalytic activity of the tungsten species.
    Type: Grant
    Filed: January 19, 2023
    Date of Patent: April 16, 2024
    Assignee: T.EN Process Technology, Inc.
    Inventors: Thomas P. Binder, Louis Kapicak
  • Patent number: 11958795
    Abstract: A chloride salt eliminator system and method for removal of chloride salt from glycol circulated through a reboiler in natural gas dehydration, in a continuous process, close to the wellhead. Hot glycol from the reboiler is pumped into a salt eliminator unit having independently replaceable filter elements which trap chloride salts which are not soluble in hot glycol and pass clean glycol for return to the reboiler.
    Type: Grant
    Filed: March 9, 2022
    Date of Patent: April 16, 2024
    Assignee: GLY-TECH SERVICES, INC.
    Inventor: Michael J. Palasch
  • Patent number: 11958796
    Abstract: The present invention relates to a compound having the general formula (1) wherein in the general formula (1) the residues R1 to R8 and Ar are the same or different and are independently from each other selected from the group consisting of hydrogen, unsubstituted hydrocarbon groups, substituted hydrocarbon groups and inorganic groups, wherein at least one of the residues R1 to R8 and Ar is a hydrophilic group, such as for instance a group comprising one or more polyethylene groups.
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: April 16, 2024
    Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
    Inventors: Qiang Chen, Akimitsu Narita, Klaus Müllen, Sapun Parekh, Mischa Bonn, Xiaomin Liu
  • Patent number: 11958797
    Abstract: The application relates to a process for the preparation of a compound of formula (II) by cyclisation of a polyene of formula (I), and to an intermediate of formula (III). The obtained compounds are useful intermediates in the preparation of specific isoprenoids, preferably in the production of vitamin A and derivatives of vitamin A.
    Type: Grant
    Filed: April 3, 2020
    Date of Patent: April 16, 2024
    Assignee: DSM IP ASSETS B.V.
    Inventors: Fabrice Aquino, Werner Bonrath, Marc-André Mueller, Bettina Wuestenberg
  • Patent number: 11958798
    Abstract: The present invention relates to a process for the preparation of iloprost of formula I through new intermediates, isolation of iloprost of formula I in solid form, as well as preparation of the 16(S)-iloprost and 16(R)-iloprost isomers of formulae (S)-I and (R)-I and isolation of iloprost of formula I and 16(S)-iloprost of formula (S)-I in solid, crystalline form.
    Type: Grant
    Filed: October 25, 2022
    Date of Patent: April 16, 2024
    Assignee: EUROAPI HUNGARY LIMITED LIABILITY COMPANY
    Inventors: Imre Rozsumberszki, Zsuzsanna Kardos, Irén Hortobágyi, Tibor Szabó, Csaba Váradi, Tamás Bán
  • Patent number: 11958799
    Abstract: In a method for producing hydrogen and carboxylic acid, a primary alcohol of 1 to 7 carbon atoms and water are reacted by being continuously introduced into a flow reactor packed with a solid catalyst consisting of an alloy of ruthenium and tin on a support and passed through the reactor under temperature and pressure conditions at which the water assumes a gaseous state. This method enables hydrogen and carboxylic acid to be produced in a high yield or at a high purity from a primary alcohol and water in a short time and by simple operations.
    Type: Grant
    Filed: October 14, 2022
    Date of Patent: April 16, 2024
    Assignees: KYOTO UNIVERSITY, SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Haruo Kawamoto, Eiji Minami, Yuanyuan Zhao, Takashi Nomura, Kazuto Kobayashi, Akiko Miki
  • Patent number: 11958800
    Abstract: The invention relates to a method for preparation of (meth)acrylic acid esters from (meth)acrylic acid anhydrides. Wherein the method for preparation of the (meth)acrylic acid ester, comprises at least step (a) as follows: (a) reacting a (meth)acrylic acid anhydride of Formula (I): wherein R1 is a hydrogen atom or a methyl group; with a substrate in the presence of a first catalyst to form a product mixture comprising the (meth)acrylic acid ester; and wherein: the substrate is selected from the group consisting of: primary alcohols; secondary alcohols; tertiary alcohols; and phenols; and the first catalyst comprises a salt of magnesium or of a rare earth element.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: April 16, 2024
    Assignee: Evonik Operations GmbH
    Inventors: Marcel Treskow, Silvia Beyer, Thorben Schutz, Steffen Krill
  • Patent number: 11958801
    Abstract: A process for process for preparing 6-isopropenyl-3-methyl-9-decenyl acetate of the following formula (3), wherein Ac represents an acetyl group, the process comprising steps of: preparing a nucleophilic reagent, 5-isopropenyl-2-methyl-8-nonenyl compound, of the following general formula (1): wherein M1 represents Li, MgZ1, ZnZ1, Cu, CuZ1, or CuLiZ1, wherein Z1 represents a halogen atom or a 5-isopropenyl-2-methyl-8-nonenyl group, from a 5-isopropenyl-2-methyl-8-nonenyl halide compound of the following general formula (4): wherein X1 represents a halogen atom; subjecting the nucleophilic reagent (1), 5-isopropenyl-2-methyl-8-nonenyl compound, to an addition reaction with at least one electrophilic reagent selected from the group consisting of formaldehyde, paraformaldehyde, and 1,3,5-trioxane, followed by a hydrolysis reaction to form 6-isopropenyl-3-methyl-9-decenol of the following formula (2); and acetylating 6-isopropenyl-3-methyl-9-decenol (2) to form 6-isopropenyl-3-methyl-9-decenyl acetate (3).
    Type: Grant
    Filed: January 13, 2023
    Date of Patent: April 16, 2024
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Akihiro Baba, Takeshi Kinsho, Yusuke Nagae
  • Patent number: 11958802
    Abstract: A photopolymerization sensitizer may not cause problems of dusting or coloring of a cured product due to bleeding of additives such as the photopolymerization sensitizer on the surface, e.g., by blooming at the time of photo-curing or during storage of the cured product, and which provides a practically sufficient photo-curing rate. A 9,10-bis(alkoxycarbonylalkyleneoxy)anthracene compound having ester groups, of formula (I): wherein A is a C1-20 alkylene group, optionally branched by an alkyl group, R is a C1-20 alkyl group, optionally branched by the alkyl group, the C1-20 alkyl group optionally being a cycloalkyl group or a cycloalkylalkyl group, and X and Y are independently a hydrogen, a C1-8 alkyl group, or a halogen.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: April 16, 2024
    Assignee: Kawasaki Kasei Chemicals Ltd.
    Inventors: Akihiko Yamada, Hidehiko Tanaka, Shigeaki Numata
  • Patent number: 11958803
    Abstract: Various embodiments of the present invention are directed to methods of preparing a biogas purification system. Embodiments include flushing an adsorber with a gas stream that is separable by the downstream biogas purification process. Other embodiments include using the separable gas stream to flush a saturated adsorber. Additional embodiments include using a gas stream comprised of CO2.
    Type: Grant
    Filed: March 20, 2020
    Date of Patent: April 16, 2024
    Assignee: CALGON CARBON CORPORATION
    Inventors: Franck Michel Honore, Thomas Anthony Ryan
  • Patent number: 11958804
    Abstract: The present invention relates to the use of 2,5-furanedicarboxylate-based MOFs, such as, MIL-160(AI) metal-organic framework, for separating C6 alkane isomers into linear, mono-branched and di-branched isomers. The present invention also relates to the use of 2,5-furanedicarboxylate-based MOFs, such as, MIL-160(AI) metal-organic framework, preferably in combination with Zeolite 5A for producing higher research octane number gasoline blends. Also within the scope of the invention is a system for separating C6 and C5 alkane isomer mixtures into linear, mono-branched and di-branched fractions.
    Type: Grant
    Filed: January 7, 2020
    Date of Patent: April 16, 2024
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUTO POLITÉCNICO DE BRAGANÇA, ÉCOLE SUPÉRIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, ÉCOLE NORMALE SUPÉRIEURE DE PARIS, UNIVERSIDADE DO PORTO
    Inventors: Christian Serre, Farid Nouar, José Silva, Alírio Rodrigues, Pedro Brântuas
  • Patent number: 11958805
    Abstract: Provided herein are formulations, processes, solid forms and methods of use relating to (E)-1-(4-(1-(((4-cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)azetidine-3-carboxylic acid.
    Type: Grant
    Filed: August 18, 2020
    Date of Patent: April 16, 2024
    Assignee: NOVARTIS AG
    Inventors: Lianfeng Huang, Daozhong Zou
  • Patent number: 11958806
    Abstract: An object is to provide a method for easily producing maleimide (MI) in which trace amounts of residual acid components as impurities in a crude MI are efficiently reduced, that is, the acid value is sufficiently reduced. <1> A method for producing purified MI, comprising reducing an acid value of crude MI by 50% or more, by adding carbodiimide (CDI) to a solution comprising the crude MI to react an acid component in the crude MI with the CDI. <2> The method for producing purified MI, comprising adding 0.5% by mass or more and 8% by mass or less of the CDI with respect to a mass of the crude MI for reaction. <3> The method for producing purified MI, wherein the CDI is N,N?-diisopropyl carbodiimide (DIC). <4> The method for producing purified MI, comprising removing a urea derivative of the CDI (CDI-U) by-produced when reacting the acid component in the crude MI with the CDI.
    Type: Grant
    Filed: September 29, 2020
    Date of Patent: April 16, 2024
    Assignee: UNITIKA LTD.
    Inventors: Yuki Yamada, Tatsuya Morikita, Yosuke Sugimoto, Takeshi Yoshida, Akira Shigeta, Yoshiaki Echigo
  • Patent number: 11958807
    Abstract: The present disclosure is directed to chemical compounds and to the use of such compounds in the treatment of diseases associated with a serotonin 5-HT2 receptor.
    Type: Grant
    Filed: October 24, 2023
    Date of Patent: April 16, 2024
    Assignee: Cybin IRL Limited
    Inventor: Alex Nivorozhkin
  • Patent number: 11958808
    Abstract: An acetylsalicylic acid derivative and an application thereof. The present disclosure relates to the field of chemical pharmaceuticals, and in particular, to a compound shown in formula (I) or pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: December 26, 2019
    Date of Patent: April 16, 2024
    Assignee: ZHEJIANG HANMAI PHARMACEUTICAL TECHNOLOGY CO., LTD.
    Inventor: Jing Zhang
  • Patent number: 11958809
    Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
    Type: Grant
    Filed: September 24, 2021
    Date of Patent: April 16, 2024
    Assignee: CYTOKINETICS, INC.
    Inventors: Sheng Cui, Henry Morrison, Karthik Nagapudi, Shawn D. Walker, Charles Bernard, Karl Bennett Hansen, Neil Fred Langille, Alan Martin Allgeier, Steven M. Mennen, Jacqueline C. S. Woo, Bradley Paul Morgan, Alex Muci
  • Patent number: 11958810
    Abstract: Preparation of optionally substituted dihydroisoquinolines. The present invention relates to a process for the preparation of optionally substituted dihydroi-soquinolines of the formula I.
    Type: Grant
    Filed: January 14, 2019
    Date of Patent: April 16, 2024
    Assignee: BASF SE
    Inventors: Bernd Mueller, Michael Rack, Michael Seet, Ana Escribano Cuesta, Jan Klaas Lohmann, Georg Christoph Rudolf, Markus Nett, Rainer Hoffmann
  • Patent number: 11958811
    Abstract: An 1-[4,5-bis(4-bromophenyl)-1-hexyl-1H-imidazol-2-yl]-2-naphthol compound, its synthesis, and its use as an antimicrobial agent.
    Type: Grant
    Filed: October 27, 2023
    Date of Patent: April 16, 2024
    Assignee: KING FAISAL UNIVERSITY
    Inventors: Hany Mohamed Abd El-Lateef Ahmed, Mai Mostafa Khalaf Ali, Antar Ahmed Abdelhamid Ahmed
  • Patent number: 11958812
    Abstract: Provided is a compound superior in an ATX inhibitory action and useful for the prophylaxis or treatment of diseases involving ATX. A carboxylic acid compound represented by the following formula (1) or a pharmacologically acceptable salt thereof: wherein each symbol is as defined in the SPECIFICATION.
    Type: Grant
    Filed: July 26, 2019
    Date of Patent: April 16, 2024
    Assignee: MITSUBISHI TANABE PHARMA CORPORATION
    Inventors: Taichi Takahashi, Hisayuki Takamatsu, Daisuke Iijima, Shuzo Takeda
  • Patent number: 11958813
    Abstract: A uracil compound containing a carboxylate fragment, a preparation method therefor, and a herbicidal composition and use thereof are provided. The preparation method includes a contact reaction between a carboxylic acid compound and different substituted alcohol, halogenated, or sulfonate compound in a presence of a solvent. The uracil compound containing a carboxylate fragment provided by the present invention has better herbicidal activity compared with the prior art.
    Type: Grant
    Filed: February 5, 2022
    Date of Patent: April 16, 2024
    Assignee: JIANGSU FLAG CHEMICAL INDUSTRY CO., LTD.
    Inventors: Pu Zhang, Kaicheng Yao, Yaojun Wu, Dan Xu, Pin Qian, Long Bu, Congqiang Bai
  • Patent number: 11958814
    Abstract: A 3-(4-nitrophenyl)-5-((2-isopropyl-5-methylphenoxy)methyl)-1,2,4-oxadiazole compound, its synthesis, and its use as an antimicrobial agent.
    Type: Grant
    Filed: November 2, 2023
    Date of Patent: April 16, 2024
    Assignee: KING FAISAL UNIVERSITY
    Inventors: Hany Mohamed Abd El-Lateef Ahmed, Mai Mostafa Khalaf Ali, Antar Ahmed Abdelhamid Ahmed, Amer A. Amer
  • Patent number: 11958815
    Abstract: A N?-(2-(5-phenyl-1,3,4-oxadiazol-2-ylthio)acetoxy)-2-naphthimidamide compound, its synthesis, and its use as an anti-microbial agent.
    Type: Grant
    Filed: October 11, 2023
    Date of Patent: April 16, 2024
    Assignee: KING FAISAL UNIVERSITY
    Inventors: Hany Mohamed Abd El-Lateef Ahmed, Mai Mostafa Khalaf Ali, Antar Ahmed Abdelhamid Ahmed, Amer A. Amer
  • Patent number: 11958816
    Abstract: A N?-({[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetyl}oxy)benzenecarboximidamide compound, its synthesis, and its use as an antimicrobial agent.
    Type: Grant
    Filed: October 13, 2023
    Date of Patent: April 16, 2024
    Assignee: KING FAISAL UNIVERSITY
    Inventors: Mai Mostafa Khalaf Ali, Hany Mohamed Abd El-Lateef Ahmed, Antar Ahmed Abdelhamid Ahmed, Amer A. Amer
  • Patent number: 11958817
    Abstract: A 4-chloro-N?-(2-(5-phenyl-1,3,4-oxadiazol-2-ylthio)acetoxy)benzimidamide compound, its synthesis, and its use as an antimicrobial agent.
    Type: Grant
    Filed: October 13, 2023
    Date of Patent: April 16, 2024
    Assignee: KING FAISAL UNIVERSITY
    Inventors: Hany Mohamed Abd El-Lateef Ahmed, Mai Mostafa Khalaf Ali, Antar Ahmed Abdelhamid Ahmed, Amer A. Amer
  • Patent number: 11958818
    Abstract: The present invention relates to compound of formula (I), wherein R1 is chloro, bromo iodo or a brosylate group. The present invention also relates to methods of making this compound and its use in carrying out organic transformations.
    Type: Grant
    Filed: April 29, 2020
    Date of Patent: April 16, 2024
    Assignee: Boehringer Ingelheim International GmbH
    Inventor: Nitinchandra D. Patel
  • Patent number: 11958819
    Abstract: The present invention relates to copolymers, particularly to copolymers comprising a photoactive unit, the copolymers being particularly suitable for ophthalmic devices. The copolymers include one or more different polymer units in addition to the photoactive unit, such as polymerized units derived from ethylene, propylene, an acrylate, a methacrylate, or a styrene.
    Type: Grant
    Filed: July 30, 2021
    Date of Patent: April 16, 2024
    Assignee: Johnson & Johnson Surgical Vision, Inc.
    Inventors: Lars Dobelmann-Mara, Stefan Riedmueller, Martin Schraub
  • Patent number: 11958820
    Abstract: The present invention relates to the technical field of chemical industry, and in particular to a method for purifying ethylene carbonate through dynamic crystallization, which includes the following steps: adding an ethylene carbonate-containing raw material into a cavity of a crystallization device under a condition of stirring for dynamic crystallization, wherein the crystallization device further includes a jacket attached and circumferentially disposed along the outer wall of the cavity, the jacket is provided with cooling water therein, a temperature of the cooling water is 1-2.5° C. lower than the temperature in the cavity until a granular ethylene carbonate crystal is generated. The present invention using a rake dryer as the crystallization device to realize dynamic crystallization at a certain rotating speed. The technical solution is simple to operate and short in processing cycle, which facilitates improvement in production efficiency and product quality and is suitable for industrial application.
    Type: Grant
    Filed: December 15, 2022
    Date of Patent: April 16, 2024
    Assignee: SHENZHEN CAPCHEM TECHNOLOGY CO., LTD.
    Inventors: Baichun Yang, Qiyou Huang, Zihao Ye, Ao He
  • Patent number: 11958821
    Abstract: Disclosed herein are salts and solid forms of MDMA, (R)-MDMA, (S)-MDMA, MDE, S-MDE, R-MDE, MDAI, MBDB, S-MBDB, R-MBDB, MEAI, and 5,6-Dimethoxy-2-aminoindane, including salts, solid forms of the compound and salts thereof, as well as polymorphs of solid forms. The solid forms disclosed herein may have improved properties, such as improved physical, chemical, and/or pharmacokinetic properties. Also disclosed are methods for making the salts and solid forms and methods for administering the same. The disclosed salt and solid forms of MDMA, (R)-MDMA, (S)-MDMA, MDE, S-MDE, R-MDE, MDAI, MBDB, S-MBDB, R-MBDB, MEAI, and 5,6-Dimethoxy-2-aminoindane may be useful for treating neurological disease and/or a psychiatric disorder in a subject.
    Type: Grant
    Filed: February 28, 2023
    Date of Patent: April 16, 2024
    Assignee: Terran Biosciences Inc.
    Inventor: Samuel Clark
  • Patent number: 11958822
    Abstract: Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.
    Type: Grant
    Filed: October 14, 2022
    Date of Patent: April 16, 2024
    Assignee: Corsair Pharma, Inc.
    Inventors: Cyrus K. Becker, Meenakshi S. Venkatraman, Xiaoming Zhang, Jürg R. Pfister, Gwenaella Rescourio
  • Patent number: 11958823
    Abstract: Object of the invention is a process for the manufacturing of a polymer with urethane groups, wherein in a first alternative A) a five-membered cyclic monothiocarbonate B) a compound with at least two amino groups, selected from primary or secondary amino groups, and C) a compound which at least two functional groups that react with a group —SH or, in case of a carbon-carbon triple bond as functional group that react with a group —SH, a compound with at least one carbon-carbon triple bond are reacted or wherein in a second alternative A) a five-membered cyclic monothiocarbonate and D) a compound with at least one primary or secondary amino group and at least one functional group that reacts with a group —SH.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: April 16, 2024
    Assignee: BASF SE
    Inventors: Peter Rudolf, Indre Thiel, Hans-Josef Thomas, Hannes Blattmann
  • Patent number: 11958824
    Abstract: Described are visible light absorbing compounds. The compounds have a visible light absorption maximum between 430 and 480 nm and a full width half maximum (FWHM) at the visible light absorption maximum of at least 35 nm and up to 100 nanometers, wherein the compounds are photostable. The compounds substantially mimic the visible light absorbance properties of macular pigment while remaining photostable. The compounds may be used in a variety of articles, including ophthalmic devices.
    Type: Grant
    Filed: June 11, 2020
    Date of Patent: April 16, 2024
    Assignee: Johnson & Johnson Vision Care, Inc.
    Inventor: Shivkumar Mahadevan
  • Patent number: 11958825
    Abstract: The present invention includes novel compounds containing deuterated or partially deuterated xanthene and thioxanthene structures. These compounds may be useful as host materials with high triplet energies for phosphorescent electroluminescent devices.
    Type: Grant
    Filed: January 31, 2023
    Date of Patent: April 16, 2024
    Inventor: Peter Wolohan
  • Patent number: 11958826
    Abstract: A 6?-(2-chlorophenyl)-2?-ethoxy-3,4?-bipyridine-3?-carbonitrile compound, its synthesis, and its use as an antimicrobial agent.
    Type: Grant
    Filed: October 13, 2023
    Date of Patent: April 16, 2024
    Assignee: KING FAISAL UNIVERSITY
    Inventors: Mai Mostafa Khalaf Ali, Hany Mohamed Abd El-Lateef Ahmed, Antar Ahmed Abdelhamid Ahmed, Amer A. Amer
  • Patent number: 11958827
    Abstract: A 9-(2-hydroxyquinoline-3-yl)-10-[3-(dimethylamino)propyl]-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione compound, its synthesis, and its use as an antimicrobial agent.
    Type: Grant
    Filed: November 7, 2023
    Date of Patent: April 16, 2024
    Assignee: KING FAISAL UNIVERSITY
    Inventors: Hany Mohamed Abd El-Lateef Ahmed, Mai Mostafa Khalaf Ali, Antar Ahmed Abdelhamid Ahmed
  • Patent number: 11958828
    Abstract: An 4,5-bis(4-bromophenyl)-1-hexyl-2-(3-pyridyl)-1H-imidazole compound, its synthesis, and its use as an antimicrobial agent.
    Type: Grant
    Filed: November 7, 2023
    Date of Patent: April 16, 2024
    Assignee: KING FAISAL UNIVERSITY
    Inventors: Hany Mohamed Abd El-Lateef Ahmed, Mai Mostafa Khalaf Ali, Antar Ahmed Abdelhamid Ahmed
  • Patent number: 11958829
    Abstract: A 3-(4,5-Diphenyl-2-(pyridin-3-yl)-1H-imidazol-1-yl)-N,N-dimethylpropan-1-amine compound, its synthesis, and its use as an antimicrobial agent.
    Type: Grant
    Filed: December 8, 2023
    Date of Patent: April 16, 2024
    Assignee: KING FAISAL UNIVERSITY
    Inventors: Hany Mohamed Abd El-Lateef Ahmed, Mai M. Khalaf, Antar A. Abdelhamid, Adel A. Marzouk
  • Patent number: 11958830
    Abstract: The disclosure provides at compounds of Formula I, compositions comprising the same, and methods of using the same, including use in treating a disease and/or a symptom of a disease caused by a coronavirus.
    Type: Grant
    Filed: March 29, 2021
    Date of Patent: April 16, 2024
    Assignee: WESTLAKE PHARMACEUTICALS (HANGZHOU) CO., LTD.
    Inventors: Hongtao Yu, Qi Hu, Jing Huang, Tingliang Wang, Ningke Hou, Lijing Zhang, Wenyi Zhang, Qiaozhu Tan
  • Patent number: 11958831
    Abstract: Disclosed are pyrazole compounds represented by formula (I), pharmaceutical compositions containing such compounds, a method for preparing such compounds, and use of the pyrazole compounds and the pharmaceutical compositions. Such compounds are useful for inhibiting IRAK family kinases, and also useful for treating diseases caused by IRAK family kinases, such as autoimmune diseases, inflammatory diseases and cancers.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: April 16, 2024
    Assignee: ARTIVILA (SHENZHEN) INNOVATION CENTER, LTD.
    Inventors: Chubiao Xue, Liye Huang, Hua Li, Tao Li, Huabin Liu
  • Patent number: 11958832
    Abstract: A 2-alkoxy[4,3:6,3-terpyridine]-3-carbonitrile compound, its synthesis, and its use as an antimicrobial agent.
    Type: Grant
    Filed: October 12, 2023
    Date of Patent: April 16, 2024
    Assignee: KING FAISAL UNIVERSITY
    Inventors: Hany Mohamed Abd El-Lateef Ahmed, Mai Mostafa Khalaf Ali, Antar Ahmed Abdelhamid Ahmed, Amer A. Amer
  • Patent number: 11958833
    Abstract: The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase 30 or Ubiquitin Specific Peptidase 30 (USP30). The invention further relates to the use of DUB inhibitors in the treatment of conditions involving mitochondrial dysfunction and cancer. Compounds of the Invention include compounds having the formula (I): (I) or a pharmaceutically acceptable salt thereof, wherein R1a, R1b, R1c, R1d, R1e, R1f, R1g, R2, X, L and A are as defined herein.
    Type: Grant
    Filed: August 16, 2021
    Date of Patent: April 16, 2024
    Assignee: Mission Therapeutics Limited
    Inventors: Mark Ian Kemp, Martin Lee Stockley, Andrew Madin
  • Patent number: 11958834
    Abstract: Compounds of Formula I, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth:
    Type: Grant
    Filed: August 7, 2019
    Date of Patent: April 16, 2024
    Assignee: VIIV Healthcare UK (No.5) Limited
    Inventors: Makonen Belema, Manoj Patel
  • Patent number: 11958835
    Abstract: A 6-(6-bromo-2-oxo-2H-chromen-3-yl)-4-(4-chlorophenyl)-2-alkoxynicotinonitrile compound, its synthesis, and its use as an antimicrobial agent.
    Type: Grant
    Filed: October 9, 2023
    Date of Patent: April 16, 2024
    Assignee: KING FAISAL UNIVERSITY
    Inventors: Mai Mostafa Khalaf Ali, Hany Mohamed Abd El-Lateef Ahmed, Antar Ahmed Abdelhamid Ahmed, Amer A. Amer
  • Patent number: 11958836
    Abstract: The present invention relates to a novel micronized 1,4-di(benzoxazol-2?-yl)benzene as well as to the use thereof in topical compositions.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: April 16, 2024
    Assignee: DSM IP ASSETS B.V.
    Inventors: Christine Mendrok-Edinger, Alexander Schlifke-Poschalko
  • Patent number: 11958837
    Abstract: The present invention relates to quinazolinones and related compounds which are inhibitors of PARP14 and are useful, for example, in the treatment of cancer and inflammatory diseases.
    Type: Grant
    Filed: April 14, 2021
    Date of Patent: April 16, 2024
    Assignee: Ribon Therapeutics, Inc.
    Inventors: Laurie B. Schenkel, Melissa Marie Vasbinder, Kevin Wayne Kuntz, Kerren Kalai Swinger