Abstract: A process for preparing and isolating pharmaceutical active ingredient particles having a particle size of between about 0.1 and 30 microns, wherein a slurry comprising the active ingredient and one or more pharmaceutically acceptable excipients is fed into a thin film evaporator under suitable conditions for less than 10 minutes sufficient to generate solid matrix particles comprising active ingredient and one or more excipients, wherein the particles have less than 5% residual solvent.

Abstract: The present invention provides methods for preventing, inhibiting or treating a surgical site infection associated with a surgical operation comprising the step of applying to the surgical site a biocompatible, biodegradable substrate being impregnated and/or having its surface coated fully or partially with a matrix composition which provides local controlled and prolonged release of at least one pharmaceutically active agent at the surgical site.

Abstract: The invention relates to lyophilized products and reconstituted emulsions for parenteral application, which comprise all the 13 essential vitamins (A, D, E, K1, C, B1, B2, B3, B5, B6, B7, B9, and B12) in a single container, as well as to methods for preparing them.

Abstract: This disclosure provides pharmaceutical compositions comprising midodrine, a pharmaceutically acceptable salt thereof, desglymidodrine, a pharmaceutically acceptable salt thereof, or a combination therefore that can be administered to a human subject in need thereof in a supine position. The disclosure also provides pharmaceutical compositions which can be administered once-a-day. This disclosure further provides pharmaceutical compositions comprising an extended release composition and providing a delayed release period between about 30 min to about 12 hours.

Abstract: Provided herewith is a pharmaceutical composition comprising, separately or together, a pulsatile release component comprising levodopa and a DOPA decarboxylase inhibitor for the management of OFF-time episodes in patients with Parkinson's disease.

Abstract: The present invention relates to a modified-release composition comprising orlistat and acarbose, comprising individually distinct parts with different release patterns: a) a first part, G1, comprising from about 5 to about 70% w/w of the total dose of acarbose, b) a second part, G2A, comprising from about 30 to about 95% w/w of the total dose of acarbose, c) a third part, G2B, comprising from about 10 to about 90% w/w of the total dose of orlistat, and d) a fourth part, G3, comprising from about 10 to about 80% w/w of the total dose of orlistat, and the total concentration of acarbose and orlistat, respectively, in the composition is 100% w/w.

Abstract: A method for treating a viral infection of a mammalian subject that comprises administering a virus-inhibiting amount of a halogenated xanthene, a pharmaceutically acceptable salt, an alkyl ester or amide or aromatic ester or amide derivative thereof as disclosed within, to that mammalian subject. A method of inducing a type I interferon response in a mammalian subject that presents with a microbial infection, cancerous tumor or hematological malignancy that comprises administering an amount of a halogenated xanthene as discussed above, effective to induce the type I interferon response. A method of enhancing a mammalian immunogen-specific immune response that comprises contacting mammalian cells, in vivo or present in a mammalian cell growth supporting medium, with an adjuvant-effective amount of a halogenated xanthene as discussed above, and an immunogen to which that response is to be enhanced.

Abstract: An aqueous composition for making dip-molded comestible hard capsules comprising a film forming capsule base material and one or more colorants each consisting of a hydrophilic coloring foodstuff concentrate.

Abstract: A multi phase soft gelatin dosage form comprising at least one preformed solid dosage form comprising a statin compound and at least one liquid fill phase comprising Omega-3 fatty acids. The multi phase soft gelatin dosage forms of the present invention are especially useful to combine at least one solid dosage form and at least one liquid phase for single ingestion. The solid phase, liquid phase or coatings may further comprise active pharmaceutical ingredients, nutraceuticals, nutritional supplements, or therapeutic substances, functional excipients or combinations thereof.

Abstract: Methods and delivery agents for treatment of connective tissue that includes elastic fibers are described. Delivery agents are nano- or micro-sized particles that include a biologically active compound useful in treatment of degraded elastic fibers, and an anchoring agent at a surface that binds at or near the area of degraded elastic fibers. The delivery agents may be utilized for targeted delivery of biologically active compounds to degraded elastic fibers so as to maintain and/or regenerate the elastin component of connective tissue, and to prevent further degradation and/or rehabilitate the structural architecture of the connective tissue.

Abstract: Disclosed are cationic polymers comprising monomers such as those described in Formula (I). Such polymers can be useful for the preparation of therapeutic compositions [e.g., compositions comprising nucleic acids such as m RNA). Additionally, therapeutic compositions comprising these cationic, biodegradable polymers can have improved properties and reduced toxicity.

Abstract: The disclosure provides compositions comprising dactinomycin, formulated for delivery by nanoparticle, and methods for treating a myelodysplastic syndrome (MDS) or cancer, for example, NPM1-mutated acute myeloid leukemia (AML), by administration of the compositions of the disclosure.

Abstract: Compositions, devices, and methods for transdermal administration of olanzapine and uses thereof, e.g., to treat nausea and vomiting.

Abstract: A wound dressing material includes a particle having a crosslinked gelatin derivative, the gelatin derivative having the structure represented by the following formula (1): GltnNH—CHR1R2??(1) wherein “Gltn” represents a gelatin residue, R1 represents an alkyl group having 1-17 carbon atoms, and R2 represents a hydrogen atom or an alkyl group having 1-17 carbon atoms, and the particle having a particle size ranging from 1 to 1,000 ?m.

Abstract: A hemostatic surface application device having a region of hemostatic foam for contact with a patient's skin where a wound exists or is created, the device includes: a release layer, the release layer in contact with a hemostatic flexible foam section, and a structural foam layer having a front side and a back side surrounding the hemostatic flexible foam layer, forming a generally central hemostatic surface exposed through the front side of the surrounding structural foam layer, and a support layer adhered to the backside of the structural foam layer.

Abstract: A system for treating plant material uses a vessel capable of being brought to a vacuum and/or pressurized and maintained at a relatively low temperature. Plant material is placed within the vessel and the vessel draws a vacuum or is pressurized. A control system may monitor and control the creation of a vacuum, flow rate of a gas from a gas tank into the vessel, the temperature in the vessel, the flow rate of gas out of the vessel, and the pressure of the vessel.

Abstract: An entryway sanitizing assembly for neutralizing microbes on an entrant includes a frame, which defines an opening through which a user can pass. A first sensor, which detect motion, is engaged to the frame and can detect a user approaching the opening. A lamp engaged to the frame emits ultraviolet radiation into the opening to neutralize microbes on the user passes through the opening. A plurality of nozzles is engaged to the frame and is directed into the opening. A pump is operationally engaged to the plurality of nozzles and to a reservoir containing a disinfectant solution. The disinfectant solution is pumped by the pump to the nozzles to generate a disinfectant mist to neutralize the microbes on the user passing through the opening. A controller selectively actuates the lamp and the pump upon detection of motion by the first sensor.

Abstract: A dome-style light is provided for vehicles or other environments and includes one or more sanitizing feature such as light elements and/or a disinfectant dispenser. The light elements may be UVC emitting lights. The disinfectant dispenser may include a container or tank of aerosol or liquid disinfectant. The light includes a control unit for controlling the lights and/or dispenser at certain times. The control unit may receive an output for one or more sensors, such as detectors, for detecting activity in the presence of the light, where the control unit may prevent the illumination of the light(s) or the dispensing of disinfectant when activity is detected. The light may be retrofit into a vehicle for use in disinfecting a vehicle.

Abstract: The present invention relates to an aqueous ozone floor disinfection system. A floor cleaning machine traverses a floor surface entering a pre-hygienic zone prior to cleaning, cleaning within a midst-hygienic zone for a cleaning period, and moving away from the midst-hygienic zone creating a post-hygienic zone. An aqueous ozone generator receives water and generates an ozonated concentrate liquid. A post-hygienic mixer ratiometrically blends the ozonated concentrate liquid and water to form a post-hygienic ozone disinfection solution having a predetermined post-hygienic ozone treatment concentration. A post-hygienic nozzle spray of the post-hygienic ozone disinfection solution onto the post-hygienic zone portion of the floor surface for at least a post-hygienic treatment time absent agitation or removal by the floor cleaning machine improving disinfection of the floor surface. The service life of the aqueous ozone generator can be tracked and the disinfected floor surface can be GPS geofenced.

Abstract: A breathing treatment apparatus delivers breathing gas to a user. The apparatus may be configured to comprise one or more sensors for sensing microbial growth within the apparatus.

Abstract: A chitosan for use in an antimicrobial treatment of a patient's tissue and a pharmaceutical composition comprising a chitosan for use in an antimicrobial treatment of a patient's tissue. A method of treating a microbial infection, the method comprising the step of administering to a patient an effective amount of a chitosan and an aqueous solution comprising chitosan. A chitosan or a pharmaceutical composition comprising a chitosan for use in an epithelial cell growth stimulating treatment of a patient's tissue. A method of stimulating the growth of epithelial cells the method comprising the step of administering to a patient or to an epithelial cells containing cell culture an effective amount of a chitosan or a pharmaceutical composition comprising chitosan. A tissue dressing material characterized in that it consists of chitosan or a chitosan comprising composition.

Abstract: The present invention relates to protein biocoacervates and biomaterials and the methods of making and using protein biocoacervates and biomaterials. More specifically the present invention relates to protein biocoacervates and biomaterials that may be utilized for various medical applications including, but not limited to, drug delivery devices for the controlled release of pharmacologically active agents, coated medical devices (e.g. stents, valves . . . ), vessels, tubular grafts, vascular grafts, wound healing devices including protein suture biomaterials and biomeshes, dental plugs and implants, skin/bone/tissue grafts, tissue fillers, protein biomaterial adhesion prevention barriers, cell scaffolding and other biocompatible biocoacervate or biomaterial devices.

Abstract: A method for preparing a biocompatible tissue for revitalization thereof, wherein such tissue has an essentially tubular shape. The method provides inserting a support that mainly extends along a longitudinal extension axis inside the cavity defined by the tissue and performing on the outer and/or inner surface of the tissue a plurality of holes spread out on at least one of the generatrixes of the tissue. Holes are made with a depth which occupies at least a part of the thickness of the tissue.

Abstract: A method of preventing tissue adhesion includes forming an incision in tissue, applying a hydrogel to tissue through the incision, and closing the incision with the hydrogel therein. The hydrogel includes a polymer non-covalently cross-linked with a plurality of nanoparticles and prevents a formation of adhesions between tissues and/or organs.

Abstract: Provided are multilayer synthetic rubber compositions formed from a layer of a styrene block copolymer composition and a layer of one or more synthetic elastomers, such as polychloroprene, polyisoprene, nitrile rubber, styrene butadiene rubber, butyl rubber and polyurethane. The multilayer compositions find use in the manufacture of thin walled articles, for example gloves, particularly medical or industrial gloves.

Abstract: Described are medical devices including expandable tubular bodies configured to be implanted into a lumen, wherein the outer surface of the expandable tubular bodies are coupled to a polymer(s).

Abstract: An aroma diffuser using a cassette type aroma bottle: includes a cassette type aroma bottle with a carrier having capillary pores for absorbing an aroma liquid, and a heater for heating the aroma liquid in the capillary pores of the carrier to dissipate the aromatic molecules into the outside air. When the aroma liquid is used up, the cassette type aroma bottle can be easily and rapidly detached for replacement. The aroma liquid absorbed by the carrier will not flow out of the carrier even if the cassette type aroma bottle is tilted or dumped during use or movement, ensuring safe use.

Abstract: A breast milk collection and storage system and methods of use is described. The breast milk collection and storage system may include a milk container operable to hold and store breast milk for an extended period of time. The milk container may include a container wall with an oxygen blocking layer, a light blocking layer, and an inner surface that is non-adherent for lipids and proteins, a container opening surrounded by the container wall, and a foil seal operable to seal the container opening. The milk container may have low oxygen head space and a storage system to enable the rapid cooling of the breast milk.

Abstract: A medical treatment system, such as a peritoneal dialysis system, may include a control and other features to enhance patient comfort and ease of use. For example, a cycler device may include a heater bag receiving section and a lid mounted to cover and uncover the heater bag receiving section, potentially enabling faster heating of a dialysate. A user interface may be moveable to be received into the receiving section and covered by the lid, if desired. The system may detect anomalous conditions, such as tilting of a housing of the system, and automatically recover without terminating a treatment. The system may include noise reduction features, such as porting pneumatic outputs to a common chamber, and others. The system may also automatically detect any one of several different solution lines connected to the system, and control operation accordingly, e.g., to mix solutions provided by two or more lines and form a needed dialysate solution.

Abstract: A hemodialysis system is disclosed. The hemodialysis system includes a dialyzer, a saline container including saline, and a disposable set comprising a blood pumping tube fluidly connected to a first end of the dialyzer, an arterial line fluidly connected to a first end of the blood pumping tube, a venous line fluidly connected to a second end of the dialyzer, a saline line fluidly connected to the blood pumping tube and the saline container, and a dialyzer line fluidly connected to a second end of the blood pumping tube and a second end of the dialyzer. The hemodialysis system also includes a dialysis instrument comprising an arterial line clamp, a venous line clamp, and a saline valve. The saline rinses blood out of the arterial line when the venous line clamp is closed, the arterial line clamp is opened, and the saline value is opened.

Abstract: A system and a method for renal replacement therapy includes a blood treatment unit connected to a blood circuit and a dialysis fluid circuit, the system further including a control unit configured to control the system according to control instructions during a treatment, so as to determine a system parameter value and an indication of membrane fouling of the membrane, and activate an automatic anti-fouling measure that includes a temporary change of the flow rate in the blood circuit and a temporary decrease of the ultrafiltration rate wherein a timing of the temporary change and a timing of the temporary reduction are synchronized.

Abstract: A medical treatment system includes a disposable fluid circuit that includes a water inlet and a batch container arranged to hold a mixture, the mixture including water that is received from the water inlet and at least one concentrate. The fluid circuit also includes a drain line for draining fluid from the disposable fluid circuit, and a manifold with a plurality of fluid lines, the manifold connecting the water inlet, the batch container, a source of the at least one concentrate, and the drain line. A source of purified water supplies the purified water to the water inlet and a sensor detects a property of fluid in the disposable fluid circuit. A controller controls flowing of a first fluid followed by displacement by a second fluid causing the first fluid to flow to the sensor.

Abstract: The presently disclosed subject-matter provides specific compositions, conjugates, device, kits and systems for depleting fibrinolytic agents from biological fluids. The presently disclosed subject-matter further relates to the resulting biological fluid products that are devoid in fibrinolytic activity, therapeutic methods and uses thereof. The conjugates comprise a particle, at least one linker and at least one amino acid, derivative thereof or analog thereof being at least one of 4-(aminomethyl)-cyclo-hexane-carboxylic acid (tranexamic acid), epsilon-amino caproic acid, lysine, cyclohexanecarboxylic acid and 4-methyl-cyclohexanecarboxylic acid. A plurality of different conjugates (e.g. differing in particle size or type of linker) can be used.

Abstract: A dialysis system may include a blood circuit, a cassette, a subsystem having a processor, a sensor, and a blood pumping mechanism, a housing in which the subsystem is arranged, a movable support arranged in the housing and configured to hold the sensor and/or the blood pumping mechanism of the subsystem, a cassette holder configured to removably receive the cassette, and a loading system. The loading system may be configured to move the movable support, e.g. by an axial movement, to a first position and to a second position relatively to the housing while the cassette holder is fixedly arranged in the housing. The loading system may have an electric motor controlled by the processor, a drive assembly coupled to the electric motor, and a guiding assembly configured to cooperate with the drive assembly.

Abstract: Embodiments of apparatuses and methods for providing negative pressure wound therapy to multiple wounds are disclosed. In some embodiments, presence of blockage in one or more fluid flow paths connecting a negative pressure source to one or more dressings can be performed. Determination of a blockage can be performed based on comparing one or more pressure measurements to at least one threshold. The at least one threshold can be determined based on detected capacities of the one or more dressings.

Abstract: A device for moving contents of a tube by acting on the exterior of the tube is provided. The device includes a housing having a tube passageway extending along a length thereof for holding a tube therein. A first roller and a second roller are moveable between a first position and a second position and configured to compress the tube in the second position. A first roller chassis is coupled to the housing for mounting the first roller therein and a second roller chassis is coupled to the housing for mounting the second roller therein. The first and second roller chassis are moveable between a first position in which the tube is disengaged and a second position in which the tube is engaged. A lever operably coupled to the housing causes the first or second roller to pivot and engage the tube positioned within the passageway.

Abstract: A system for aseptic collection of mammalian amniotic fluid. The system includes a cannula having an attachment end and external end. The attachment end provides a concentric opening to a hollow chamber disposed about a central passage. The hollow chamber has a port disposed adjacent to the external end permitting at least a partial suction to be established within the hollow chamber, the attachment end thereby suctionally attached to a surface when the attachment end is disposed upon the surface. The central passage provides access to a central portion of the surface surrounded by the concentric opening of the hollow chamber. An extraction needle is disposed within the central passage of the cannula and presented to the central portion of the surface. The extraction needle penetrates the central portion of the surface and extracts amniotic fluid there beneath. An associated method of use is also provided.

Abstract: A syringe-shaped spraying device includes: a barrel; a nozzle; a packing disposed therebetween; and a core disposed inside the nozzle. The nozzle is connected to a connecting portion provided at a front end of the barrel. The nozzle has a first facing surface facing a front end surface of the connecting portion and a second facing surface facing an outer circumferential surface of the connecting portion. The outer circumferential surface is provided with an annular recess portion, and the second facing surface is provided with a first annular protrusion portion and a second annular protrusion portion. By engaging the first annular protrusion portion with the annular recess portion, the packing is compressed in an axial direction by the front end surface and the first facing surface. The second annular protrusion portion is in pressure contact with the outer circumferential surface of the connecting portion entirely in a circumferential direction.

Abstract: An aerosol generating device for receiving an aerosol generating article includes an electrical circuit including a controller for determining a change in an electrical property of the circuit. The change in the electrical property of the circuit is caused by the user interacting with an aerosol generating article received by the device.

Abstract: Systems and methods are provided for delivering one or more drugs. In some embodiments, a drug delivery system includes a housing having a distal end with an inlet through which an inspiratory flow of air passes into the housing, a proximal end having a patient interface attached thereto, the patient interface being configured to interface with a user, and an inspiratory flow pathway extending from the distal end to the proximal end of the housing. A nitric oxide (NO) source is positioned within the housing and is configured to deliver NO-containing gas to the patient interface. A secondary drug source is positioned within the housing and is configured to deliver a secondary drug to the patient interface. A controller is configured to control an amount of NO-containing gas and an amount of the secondary drug delivered using a control scheme.

Abstract: A medication delivery system having a holding chamber capable of delivering dosages of medicament from a metered dose inhaler. The holding chamber includes an actuator detector, a flow detector, and a display. In another embodiment, a medication delivery system includes a holding chamber having an input end and an output end, a metered dose inhaler operably coupled to the input end of the holding chamber, and a metered dose inhaler identifier associated with the holding chamber and operable to identify the metered dose inhaler coupled to the holding chamber.

Abstract: An accessory (50,80) adapted to be used with a breath actuated inhaler (10), the breath actuated inhaler (10) comprising an air inlet (19), an outlet (20) for delivering medicament and a trigger mechanism (30) for triggering the delivery of a dose of the medicament in response to a flow (40) between the air inlet (19) and the outlet (20), wherein the accessory comprises: a pressure assist unit (52, 54) for application to the air inlet, comprising an assist chamber (52) for holding a volume of air and a mechanical release system (54, 70) for expelling air from the assist chamber to the air inlet, at a rate sufficient to trigger the trigger mechanism. Hence, it has an assist chamber for holding a volume of air and a mechanical release system for expelling air from the assist chamber to the air inlet, at a rate sufficient to trigger a dose trigger mechanism of the breath actuated inhaler.

Abstract: A control device for an electronic aerosol provision system is provided. The control device is configured to receive a replaceable component to form an electronic aerosol provision system. The control device includes a communication interface for performing communications external to the electronic aerosol provision system; a memory configured to hold a set of stored identifiers; and a control system. The control system is configured to: receive control information from a remote server via the communication interface; update the set of stored identifiers based on the control information received from the remote server; receive an identifier from a replaceable component received by the control device; make a comparison of the received identifier against the set of stored identifiers; and perform a control action for the electronic aerosol provision system dependent upon the result of said comparison.

Abstract: An electronic smoking article includes an outer tube extending in a longitudinal direction, an inner tube within the outer tube and including a pair of opposing slots, a liquid supply comprising a liquid material, a coil heater, a wick and a mouth end insert. The coil heater is located in the inner tube. The coil heater is formed of an iron-free, nickel-chromium alloy and has substantially uniformly spaced windings. The wick is surrounded by the coil heater such that the wick delivers liquid material to the coil heater and the coil heater heats the liquid material to a temperature sufficient to vaporize the liquid material and form an aerosol in the inner tube.

Abstract: An emergency ventilation system ventilates a patient and includes a chamber housing defining a breathing chamber; a piston; and a motor operably connected to the piston. The motor applies an exhalation force to move the piston in an exhalation direction applies an inhalation force to move the piston in an inhalation direction. The piston increases air in the breathing chamber as the exhalation force is applied and decreases air in the breathing chamber as the inhalation force is applied. An exhalation check valve allows airflow from the air source to the breathing chamber and not to allow airflow from the breathing chamber to the air source as the inhalation force is applied. An inhalation check valve allows airflow from the breathing chamber to the air output and not to allow airflow from the air output to the breathing chamber as the exhalation force is applied.

Abstract: An endo-tracheal catheter for use in an anesthetic procedure comprises a catheter tube to be inserted into the trachea of a patient, the catheter tube having a tubular wall defining an inner lumen for guiding a gaseous flow, and a connection piece which defines a chamber in fluid connection with the catheter tube and comprising a port for connecting a detection device to the endo-tracheal catheter for detecting at least one substance in the gaseous flow flowing through the catheter tube. An insert tube is received in the inner lumen of the catheter tube for guiding the gaseous flow through the catheter tube and/or a coating covers the tubular wall at a side facing the inner lumen for guiding the gaseous flow through the catheter tube.

Abstract: The invention relates to a positioning sputum suction laryngeal mask. The positioning sputum suction laryngeal mask comprises a mask body and a mask body tube, wherein the mask body comprises a mask body bottom plate and a mask main body arranged on the mask body bottom plate, a central region in the mask main body is provided with a mask body cavity communicated with the mask body tube, a stomach decompression tube corresponding to the stomach mouth is arranged on the back side of the mask body bottom plate, and the stomach decompression tube is isolated from the mask body cavity through the mask body bottom plate. The positioning sputum suction laryngeal mask also comprises a connection suction mechanism capable of realizing negative pressure suction in a gas supply process.

Abstract: A guide, system and method for endotracheal intubation using a pre-shaped, curvilinear guide to deliver a flexible bougie into the trachea under videoscopic visualization. The guide comprises an elongate tube with sufficient rigidity to maintain a pre-shaped path with multiple curvatures to provide a conduit through which the bougie is passed to the proper location and orientation with respect to the glottis and upper trachea.

Abstract: Intubation devices and methods of intubating a patient are provided. The intubation devices include a laryngeal mask airway (LMA) component having a mask portion and a tube portion and an endotracheal tube (ETT) component positioned in the laryngeal mask airway (LMA) component having a translatable and/or rotatable endotracheal tube. The endotracheal tube can be translated and/or rotated by a manipulation rod extending through the laryngeal mask airway (LMA) component and mounted to the endotracheal tube (ETT). The intubation devices may include inflatable cuffs adapted to manipulate the positioning or orientation of the endotracheal tube and/or to seal openings about the endotracheal tubes. Various ports, passages, and conduits are provided to enhance the use and manipulation of the intubation device.

Abstract: A low-noise breathing mask includes an elastic liner, a mask body, and a noise reduction component. The noise reduction component includes a ventilation opening and a muffler. The ventilation opening is provided on the mask body and communicates with a third opening. The muffler is connected to the mask body and covers the ventilation opening. The muffler has a first surface facing the external environment and a second surface opposite to the first surface. The first surface has a first breathable area exposed to the external environment, and the second surface has a second breathable area exposed to the cavity. The muffler also has multiple breathable channels that communicate with the first and the second breathable area, allowing gas in the cavity to be discharged to the external environment through the muffler. The multiple breathable channels in the muffler can render the gas flow smaller and less turbulent.