Abstract: A device for delivering gas includes a frame, a gas delivery hose, and a noise reduction component. The gas delivery hose is detachably connectable to the frame. The noise reduction component includes a ventilation port and a muffler. The ventilation port is provided in communication with the cavity of the frame, and the muffler is connected to the frame and covers the ventilation port. The muffler has a first surface having a first breathable area exposed to the external environment, and a second surface having a second breathable area exposed to the cavity. The muffler also has multiple breathable channels connecting the first breathable area and the second breathable area, allowing gas in the cavity to be discharged from the muffler to the external environment. The multiple breathable channels in the muffler can disperse the gas flow, making it less turbulent and reducing the noise generated.

Abstract: A patient interface includes a plenum chamber pressurisable to a therapeutic pressure, a seal-forming structure to maintain the therapeutic pressure in the plenum chamber, and a positioning and stabilising structure (PSS) to provide a force to hold a seal-forming structure on a patient's head. The PSS has at least one arm to be positioned adjacent to a cheek of the patient, and a strap removably received around the arm to contact a posterior region of the patient's head. The strap has a first coupling having a mechanical connector to engage the arm and limit movement of the arm into and out of the cavity, a second coupling spaced apart from an outer surface of the first coupling, and a sleeve being folded over the second coupling and positioned between the first and second couplings.

Abstract: An oral capnography accessory device provides a pathway for sampling oral exhalations of carbon dioxide from a mouth of a patient. The device is used in combination with a bite block. The device includes a main body extending linearly along a longitudinal axis, latch arms extending from a buccal facing surface of the main body and forming a cavity into which the bite block is insertable, and tube attachment extending from a lingual facing surface of the main body. Tubing is insertable through a passageway therethrough of the tube attachment. The device is configured for use with a nose or face mask, and with a monitoring system.

Abstract: Apparatus for generating a supply of air at positive pressure for the amelioration or treatment of a respiratory disorder comprising a housing, a blower structured and configured to produce a flow of air at positive pressure, a flexible connector electrically and physically connected to the blower; and a blower rotation limitation structure configured to reduce rotation of the blower during use. The apparatus may comprise first and second blower suspensions for holding opposite ends of the blower. The blower suspension(s) may be flexible and in tension. The apparatus may comprise one or more connector anchors for anchoring a longitudinal middle section of the flexible connector to another part of the apparatus.

Abstract: The invention relates to a breathing assistance apparatus that may be configured to reduce the risk of damage to electronics within the apparatus as a result of liquid leaks within the apparatus or impacts to the apparatus. In other forms, the apparatus may be configured to allow for easy assembly and/or safe operation.

Abstract: The present disclosure pertains to automatically predicting a slow wave response of a subject to sensory stimulation during a sleep session. The sensory stimulation may be delivered to the subject upon detection of deep NREM sleep. The sensory stimulation may be auditory, haptic, visual, or other stimulation. The system delivers stimulation to the subject in blocks of stimulation separated from one another be intra-block intervals. The blocks are separated from each other by inter-block stimulations. The system compares the stimulated slow wave activity of the subject to the unstimulated slow wave activity of the subject. The system may update the stimulation parameters based on the comparison and deliver a subsequent block stimulation. Once the comparison indicates that the stimulated slow wave activity is significantly different from the unstimulated slow wave activity, the system may apply continuous fixed sensory stimulation to the user according to the most recent stimulation parameters.

Abstract: Disclosed are methods of using planar or defocused acoustic waves for providing non-invasive sonodynamic therapy. The method includes acoustically coupling an array of piezoelectric transducers to a patient. A controller is configured to generate an electrical drive signal at a frequency selected from a range of frequencies, modulate the drive signal, and drive the transducer with the modulated drive signal at the frequency to produce modulated acoustic waves to produce an average acoustic intensity sufficient to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.

Abstract: A flexible catheter includes an elongated body, a first monolithic wire, and a second monolithic wire. The first monolithic wire forms a first sensor that is disposed in the distal end portion of the elongated body. The first sensor is configured to detect the position of a distal end of the elongated body within anatomy of a patient. The second monolithic wire forms a second sensor that is disposed in the distal end portion of the elongated body a known distance from the first sensor. The first and second sensors are configured to determine the position of the distal end portion within six degrees-of-freedom. A method of manufacturing the flexible catheter is also provided.

Abstract: Medical devices and methods for using medical devices are disclosed. An example medical device includes a catheter having a proximal end region and a distal tip and an array of sealed chambers disposed along the distal tip, wherein each of the chambers includes a distal membrane disposed along an outer surface of the distal tip and a proximal membrane extending radially inward from the outer surface. Further, each proximal membrane is configured to shift between a first position and an expanded position in response to a change in pressure within the chamber.

Abstract: A stabilization device configured to stabilize an access device when a distal end portion of the access device is inserted through a target location of a patient. The stabilization device includes a coupling surface, a proximal surface, and a base surface. The coupling surface is configured to be placed in contact with an adapter coupled to a proximal end portion of the access device. The proximal surface forms at least one angle and is configured to facilitate securement of the stabilization device to the target location. The base surface forms a contoured portion configured to be placed in contact with the target location and a recessed portion configured to be spaced apart from the target location. The stabilization device is configured to be secured to the target location such that the adapter is retained in a fixed position relative to the coupling surface and the access device is stabilized.

Abstract: A peripheral intravenous catheter assembly may include a low-drag septum. The septum may include a body having a distal end and a proximal end, which may be sealed. The septum may include a slot disposed within an outer surface of the body and oriented along a longitudinal axis of the body. The slot may include a distal end spaced apart from the distal end of the body, and a proximal end spaced apart from the proximal end of the body. An introducer needle may extend through the slot.

Abstract: Balloon catheters, methods for preparing balloon catheters, and uses of balloon catheters are disclosed. The balloon catheter includes an elongate member, an expandable balloon, and a coating layer overlying an exterior surface of the expandable balloon. The coating layer includes a total drug load of a hydrophobic therapeutic agent and a combination of additives including a first additive and a second additive. The hydrophobic therapeutic agent is paclitaxel, rapamycin, or paclitaxel and rapamycin. The first additive is a surfactant. The second additive is a chemical compound having one or more hydroxyl, amino, carbonyl, carboxyl, acid, amide, or ester groups.

Abstract: A method and apparatus for delivery of cell therapies, introduced via percutaneous access to the circulation, and delivered to the site of vascular injury intervention.

Abstract: The present invention relates to an enema device comprising a delivery container arranged for accommodating an enema and an applicator nozzle for dispersing the enema, and wherein the delivery container is arranged as a hand held pump and for remaining in an at least partly compressed configuration when the user releases the pressure on said delivery container during use. Thereby is provided a simple, inexpensive and essentially maintenance free enema device which can be used for self-administrating of an enema.

Abstract: A drug delivery device capable of forming a medicated mist that reaches the nasal and paranasal sinus cavities contains a puncturing element within its canister. The puncturing element is used in combination with a compartment that contains a filling. The compartment is optionally detachable from an interior of the device or entirely separate from the device. The puncturing element punctures the compartment, releasing the filling into the reservoir of the device to provide a medicated liquid. The device may store any form of medication so long as the medication remains stable. When dry powder forms are desired, the reservoir and/or compartment may be filled with a solution or diluent so as to form the medicated liquid, which may then be dispensed as a mist through the device following the puncturing.

Abstract: A drug delivery system that includes an elongated inert support and at least two reservoirs containing a pharmaceutically active ingredient. The inert support has a number of wall segments that define at least two compartments arranged for accommodating the at least two reservoirs. The inert support is made of a material which prevents migration or diffusion of the active ingredient from one reservoir into the other or into the support. Since the drug delivery system is divided into compartments, one for each reservoir containing an active ingredient, the release rates of each active ingredient can be independently controlled or adjusted. This is due to the fact that there is no interaction between the active ingredients, and accordingly the active ingredients will not influence each other physically or chemically.

Abstract: A medical connector for minimizing discomfort to a patient may include a substantially rigid inner body and a flexible outer body having a patient interfacing surface and coupled to at least a portion of the substantially rigid inner body. The patient interfacing surface may include a cushion material. The cushion material may be interposed between the substantially rigid inner body and the patient's skin when the medical connector is attached to the patient.

Abstract: A medical connector can include a body having a fluid path with an inlet port, an outlet port, a luer portion, and a post extending through a fluid path. An arm having a latch member is coupled to the body to engage a ridge or thread on an exterior surface of a reciprocal connector. The arm may also include an extension. When the connector is in an open position, the latch member restricts retraction of the reciprocal connector from the outlet port. A seal is coupled to the body and includes a flap extending across the outlet port or a bellows to compress along an axis. In a closed position, the post restricts flow through the luer portion. In an open position, the post permits flow through the luer portion.

Abstract: A disinfection cap is described for connection to a medical connector, the disinfection cap includes a housing having a top wall and sidewall forming a cavity, disinfectant or antimicrobial agent and a ball disposed within the cavity. An outer surface of the housing includes a thread sufficient to interlock with a mating feature of a threaded connector, or more specifically a male luer connector. The cap may also include a peelable seal to prevent the disinfectant or the antimicrobial agent from exiting the cavity. The cavity of the cap may also include one or more ribs disposed on the inner surface of the cavity to retain the ball in the cavity, forming a flow channel as the ball is depressed further into the cavity. An exterior sidewall surface of the housing may include a plurality of grip members.

Abstract: This disclosure relates to symmetric tubing clamps for blood treatment systems and related systems and methods. In some aspects, a tubing clamp includes a resilient body that has symmetry with respect to a first plane with a normal along a longitudinal axis of the resilient body, the resilient body comprising a sidewall defining an opening such that a tubing is arrangeable through the opening along the longitudinal axis of the resilient body; first and second snap-fit features configured to engage with each other when the resilient body is compressed along a direction transverse to the longitudinal axis; and a protrusion configured to constrict the tubing when the resilient body is compressed along the direction transverse to the longitudinal axis.

Abstract: Roller clamp for regulating the flow of a fluid through an elastically deformable tubing including a generally channel-shaped body whose bottom wall has a clamping surface with a longitudinal groove with a cross-section decreasingly variable from an initial end towards a terminal end. The longitudinal groove is arranged asymmetrically with respect to the lateral walls of the body.

Abstract: A system includes a delivery system a tube having a first open end and a second closed end, wherein the inner wall of the tube exhibits or includes surface roughness, a first liquid volume including a first liquid within the tube, and a first gas volume within the tube adjacent the first open end and separating the first liquid volume from a surrounding environment. The system further include a drive system, remote from the delivery system, which is configured to transmit a signal to controllably oscillate the first gas volume and one or more other gas volumes within the tube.

Abstract: An engagement mechanism associated with a reciprocally movable piston of a fluid injector is configured for releasably engaging an engagement portion at a proximal end of a rolling diaphragm syringe having a flexible sidewall configured for rolling upon itself when acted upon by the piston. The engagement mechanism has a plurality of engagement elements reversibly and radially movable relative to the engagement portion of the syringe between a first position, where the plurality of engagement elements are disengaged from the engagement portion of the syringe, and a second position, where the plurality of engagement elements are engaged with the engagement portion of the syringe. The engagement mechanism further has a drive mechanism for moving the plurality of engagement elements between the first position and the second position.

Abstract: A device which regulates the flow of a medical liquid includes a first and a second body, the first body featuring a first passage fluidly connected to a regulation channel, the second body featuring a second passage which may be positioned at a desired point of the regulation channel and set, during use, in fluid passage communication with the first passage by means of the regulation channel. The device includes a limiter which, once engaged, can no longer be disengaged during normal use of the regulation device, the first body or the second body featuring at least a first stop, and the limiter, when engaged, encountering the first stop in order to prevent the second passage being positioned in a predetermined portion of the regulation channel and/or at the first passage.

Abstract: An apparatus for coupling to a fluid delivery system and for receiving a fluid into the apparatus; a portion of the apparatus permitting a change in shape or size to accommodate the fluid volume or pressure received therein. The apparatus including a housing with a cavity, an expandable reservoir with an opening and a passage, and a cap; the expandable reservoir positioned within the cavity and coupled to a fluid source. The expandable reservoir includes an unrestrained orientation when a fluid volume or pressure therein is below a threshold, and an expanded orientation, when the fluid volume or pressure therein is above the threshold; the expandable reservoir moving toward the expanded orientation to accommodate a fluid volume or pressure received through an opening, and the expandable reservoir moving toward the unrestrained orientation to direct a fluid volume or pressure through an opening.

Abstract: Methods and systems are provided for determining fluid administration. The system may determine fluid administration based on the fluid responsiveness and regional oxygen saturation of a subject. The system may receive the fluid responsiveness and regional oxygen saturation from external sources or may determine one or both based on received physiological signals. In some embodiments, the system may determine whether to administer fluid based on the fluid responsiveness and regional oxygen saturation. In some embodiments, the system may determine the amount of fluid to administer based on the fluid responsiveness and regional oxygen saturation. In some embodiments, the system may determine the effectiveness of fluid administration. In some embodiments, the system may provide an indication of the determined fluid administration so that a care-giver can implement the appropriate fluid administration. In some embodiments, the system may control the fluid administration based on its determination.

Abstract: The present disclosure relates to a syringe including a container, for containing a primary fluid, and at least one secondary fluid chamber configured to contain a secondary fluid. The container comprises a proximal end and a distal end and having a distal end opening at the distal end. The syringe further comprises a stopper, movably arranged within the container; and a plunger engageable with the stopper and configured to apply a force to the stopper to move the stopper within the container towards the distal end of the container, to expel primary fluid from the container through the distal end opening. The plunger is further configured to expel secondary fluid from the at least one secondary fluid chamber towards the distal end opening, to expel at least a portion of a residual volume of primary fluid through the distal end opening. A plunger system and assembly for a syringe and methods of expelling fluid from a syringe are also disclosed.

Abstract: An injection device and method are shown. Devices and methods include a forceps and a needle advancement mechanism to clamp a portion of tissue and control a depth of penetration of the needle between gripping ends of the forceps. An injection device and method are shown where selected components of the injection device such as a syringe and forceps are disposable, while the remaining portions of the injection device are reusable. Devices and methods are shown that utilize micro-needles to control a depth of penetration.

Abstract: A resin syringe includes: a syringe body made of polyolefin, and a printing layer having a shape that extends in a band around an outer surface of the syringe body. The printing layer comprises components including chlorinated polypropylene having a degree of chlorination in a range of 15 to 30%, a colorant, and a filler. A plurality of recessed portions is formed in the outer surface of the syringe body on which the printing layer is printed and the recessed portions form a shape that extends in a band around the outer surface of the syringe body and that is entirely covered by the printing layer. Each of the recessed portions has a depth of 50 nm or more and less than 1 ?m and a width of 50 nm or more and less than 1 ?m and is filled with at least one of the components of the printing layer.

Abstract: An assembly for a drug delivery device and an associated drug delivery device are provided. The device has a drug delivery device housing and a medicament contained in the drug delivery device housing. A clutch is established between the dose knob and the dial link to prevent inadvertent proximal axial movement of the lead screw away from the cartridge piston, which can lead to dosing inaccuracies.

Abstract: A needle stick protection device includes a distal shield member having a slot which allows a needle to freely pass between shielded and unshielded positions an infinite number of times. The needle stick protection device also includes a proximal base member and a hinge connecting the distal shield member to the proximal base member. A locking mechanism secures the proximal base member to the distal shield member. The locking mechanism includes a compressive sleeve of the distal shield member and a distal cylindrical collar of the proximal base member, which frictionally fit together in a manner securing the proximal base member and the distal shield member.

Abstract: An injection system includes a molded body member having a body connection member at a distal end of the molded body member. The system also includes a needle hub assembly coupled to the distal end of the molded body member. The needle hub assembly includes a needle hub coupled to the body connection member of the molded body member, a needle coupled to the needle hub, and a barbed band disposed around a proximal end of the needle hub and having a barb. The barbed band allows rotation of the needle hub assembly relative to the body connection member in a first direction, while preventing rotation of the needle hub assembly relative to the body connection member in a second direction.

Abstract: Embodiments of the present disclosure relate to a circulatory support device with an integrated cannula. In an exemplary embodiment, an apparatus for attachment to a cardiac pump, comprises an adaptor. The adaptor comprises an annular cross section configured to receive the cardiac pump. The annular cross section is secured to the cardiac pump. The adaptor also comprises a plurality of channels arranged around the adapter and a cannula comprising a proximal portion, a distal portion, and an intermediate portion comprising a braided mesh extending between the distal portion and the proximal portion. The proximal portion has a proximal end comprising a plurality of elements arranged through the channels and the distal portion comprises a plurality of wires and a tip element. The plurality of wires extend in a distal direction from the braided mesh to the tip element and are secured to the tip element. And, a coating covers at least a portion of the braided mesh.

Abstract: A component for conducting a fluid having a sensor, wherein the component comprises an inner and an outer wall, where-in the inner wall is configured to conduct the fluid, the outer wall terminates the component to the outside, and a wall region is formed between the inner and outer walls. The component in accordance with the invention is characterized in that the sensor has an electromechanical element and is arranged in the wall region at the inner wall, wherein the sensor is adapted to measure a degree of deformation of the inner wall in the region of the sensor by means of the sensor element and to output it as an electrical signal, wherein the sensor element preferably has a length and/or a width of ?50 ?m.

Abstract: A training device for training a trainee to operate a defibrillator including a housing having a shape which imitates a shape of a defibrillator, a defibrillator function emulation device attached to the housing and configured to emulate a predefined subset of functions of a defibrillator, and electrodes attached to the housing. The trainer defibrillator of the disclosure simulates a real defibrillator, but, due to limited functionality and construction, will be much less expensive than existing trainer defibrillators and will therefore be able to be distributed more widely.

Abstract: A wearable cardioverter defibrillator (“WCD”) system may include an impedance detector configured to render an impedance signal of the patient. The WCD system may determine, from the impedance signal, a characteristic of breathing by the patient that can be used as a vital sign. The WCD system may determine, from at least the breathing characteristic, whether or not a shock criterion is met. If the shock criterion is met, the WCD system may control a discharge circuit to discharge a stored electrical charge through the patient. An advantage can be that the breathing characteristic may be used to determine whether or not a patient is experiencing a condition that requires defibrillation therapy, such as sudden cardiac arrest. Even more advantages can be had in discerning the state of the patient when the breathing characteristic is combined with other data, such as from a motion detector.

Abstract: A wearable monitoring and therapeutic device includes at least two sensing electrodes. Each sensing electrode includes a metallic surface integrated in a garment. The device includes at least two therapy electrodes. Each of the at least two therapy electrodes includes a receptacle, and each receptacle includes at least one dose of conductive fluid. The device includes the garment. The garment includes a fabric that is stretchable and that is breathable and/or moisture wicking, and conductive wiring configured to at least partially electrically connect that at least two sensing electrodes to at least one defibrillator component. The device includes the at least one defibrillator component. The at least two therapy electrodes are configured to provide an electric shock to the subject. Prior to the application of the electric shock, each receptacle is configured to release the conductive fluid from the receptacle.

Abstract: Techniques are disclosed for delivering electrical stimulation therapy to a patient. In one example, a medical system delivers electrical stimulation therapy to a tissue of the patient via electrodes. The medical system determines a first change of a first sensed signal of the patient to movement by the patient and a second change of a second sensed signal of the patient to the movement by the patient. Based on the first change and the second change, the medical system selects one of the first sensed signal and the second sensed signal of the patient for controlling the electrical stimulation therapy. The medical system adjusts a level of at least one parameter of the electrical stimulation therapy based on the selected one of the first sensed signal and the second sensed signal.

Abstract: An apparatus includes an elongate thin film body extending from a first end to a second end. A plurality of electrodes is disposed on the thin film body. A plurality of electrode connection traces each coupled to a respective one of the electrodes. A plurality of attachment structures is placed at predetermined locations about the thin film body. An outer molding surrounds the thin film body. The attachment structures provide connection points for the outer molding, thus allowing for adhesion between the outer molding and the thin film body.

Abstract: Systems and methods for cardiac pacing are provided, where a pacing lead is placed at or near the bundle of His. A method for pacing a heart of a patient comprises: introducing a sheath to vasculature of the patient; steering the sheath within a coronary sinus in the heart to lodge a distal end of the sheath to a target location proximal to the bundle of His above a septum separating a left ventricle and a right ventricle of the heart; advancing a pacing lead through a lumen of the sheath to the target location; coupling the pacing lead to cardiac tissue at the target location; removing the sheath; and electrically pacing the bundle of His using the pacing lead.

Abstract: The present invention promotes the activation of various physiological functions according to the stimulation of the body by superimposing a reference wave microcurrent of a low frequency and a main wave microcurrent of a high frequency into a preset pattern, or by additionally superimposing a multiple superimposed wave microcurrent discretely having a frequency of a larger magnitude sequentially than the main wave microcurrent and applying it to living organisms, and enables that the use and expandability can be increased by providing an additional configuration in which a multifunctional portable housing that can select AC electric stimulation and DC electric stimulation is worn on the wrist of the human body, thereby enabling the application of an electrical stimulation tailored to the body or disease/health condition of a user.

Abstract: Provided is a stretchable wiring board including: a base material having stretchability; a wiring line having at least a portion coated and formed on the base material with a conductive stretchable material; and an uneven engaging portion that is electrically connected to the wiring line and has a protrusion or a recess configured to engage with a connection terminal of an external device.

Abstract: A hearing-aid apparatus includes an audio collector, an audio processor, a speaker and an inner-ear implant device. The audio collector collects audio information. The speaker generates a sound wave by reference to the audio information. The sound wave is transmitted to an inner ear of a user. The inner-ear implant device is implanted aside a round window of the user for generating an electrical signal encoded by the audio processor based on the audio information to stimulate high frequency auditory nerve cells of the user with an electrode of the inner-ear implant device. The audio wave sent to the inner ear of and the electrical signal stimulating the auditory nerve cells together form an integrated auditory recognition corresponding to the audio information.

Abstract: A method and a cochlea implant system for providing reliably control and stability of the ratio between the positive charge and the capacitive discharge of an electrical pulse are disclosed. The system includes an external unit configured to receive acoustical sound and process the acoustical sound into a coded audio signal, and an implantable unit configured to receive the coded audio signal. The system further comprises a pulse generating unit configured to generate a first electrical pulse of a first pulse duration and a second electrical pulse of a second pulse duration different from the first pulse duration based on the coded audio signal. The system still further comprises an electrode array including a plurality of electrodes, wherein at least one of the plurality of electrodes is configured to receive at least the first electrical pulse and the second electrical pulse, and a capacitor connected to the at least one of the plurality of electrodes.

Abstract: Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide a lower average frequency. The systems and methods for stimulation of neurological tissue may be used to increase the efficacy of treatment in patients with Parkinson's Disease.

Abstract: The present invention relates to methods for remotely and intelligently tuning movement disorder of therapy systems. The present invention still further provides methods of quantifying movement disorders for the treatment of patients who exhibit symptoms of such movement disorders including, but not limited to, Parkinson's disease and Parkinsonism, Dystonia, Chorea, and Huntington's disease, Ataxia, Tremor and Essential Tremor, Tourette syndrome, stroke, and the like. The present invention yet further relates to methods of remotely and intelligently or automatically tuning a therapy device using objective quantified movement disorder symptom data to determine the therapy setting or parameters to be transmitted and provided to the subject via his or her therapy device. The present invention also provides treatment and tuning intelligently, automatically and remotely, allowing for home monitoring of subjects.

Abstract: Methods and systems for assisting a patient to reprogram parameters of an implantable medical device, such as a spinal cord stimulator, are disclosed. A patient may use an external controller, which may be either a dedicated device or a personal computing device, to interact with their implantable medical device and evaluate the efficacy of their therapy. If the efficacy diminishes, the patient may use their external controller to adjust either the neural dosage (i.e., frequency, pulse width, and/or amplitude) and/or the location at which stimulation is provided. A reprogramming assistant is provided, which guides the patient in adjusting their stimulation using their external controller. The patient may use supra-perception or sub-perception stimulation for the adjustment. The implantable medical device may include pre-programmed “rescue programs” to assist the patient in recovering the efficacy of their therapy.

Abstract: A cuff electrode includes at least an array of electrodes to extend circumferentially about a nerve, and methods of making and using a cuff electrode.

Abstract: A nerve stimulator and a manufacturing method thereof. The nerve stimulator includes a glass substrate, and a plurality of metal pins provided on the substrate, wherein the metal pins form stimulation portions on one side of the substrate, and the density of the metal pins is greater than 15 Pin/mm2. The stimulation portions in the present nerve stimulator have a high density and a good stimulation effect. The processing method thereof is to cut out a high-density metal pin array first by using a metal underlayer, then the manufacturing method overcomes the deficiency in the prior art that it is rather difficult to manufacture a high density of nerve stimulation electrodes by using other substrates such as ceramics and the like.

Abstract: A device may receive, from one or more electrodes, information identifying brain activity for a first time period. The device may predict, based on the information identifying the brain activity for the first time period, predicted brain activity for a second time period that is to occur after the first time period. The device may determine, based on the predicted brain activity for the second time period, a brain stimulus for the second time period, wherein the brain stimulus is associated with a frequency and a phase determined based on the predicted brain activity for the second time period. The device may cause the brain stimulus to be applied in accordance with the frequency and the phase during the second time period.