Abstract: There is a need for more effective and efficient predictive data analysis solutions for processing genetic sequencing data. This need can be addressed by, for example, techniques for performing predictive data analysis based on genetic sequences that utilize at least one of cross-variant polygenic risk modeling using genetic risk profiles, cross-variant polygenic risk modeling using functional genetic risk profiles, per-condition polygenic clustering operations, cross-condition polygenic predictive inferences, and cross-condition polygenic diagnoses.

Abstract: An improved peptide library preparation method is described for constructing complete virtual peptide libraries such as a complete virtual tripeptide library, tetrapeptide library, pentapeptide library, hexapeptide library, heptapeptide library, or a complete octapeptide library, etc. The method includes constructing an expression vector for the expression of cyclic peptides. Each cyclic peptide displays an array of peptides of different sizes and sequences, and the number of cyclic peptides needed for constructing a complete virtual peptide library can be dramatically reduced compared with conventional chemical peptide synthesis. Furthermore, the cyclic peptide libraries can be readily reproduced by the expression and purification of the cyclic peptides using the constructed gene libraries.

Abstract: Systems, devices and methods for predicting binding on an array such as a peptide array. Certain methods utilize a peptide array having a plurality of peptides with one or more defined parameters and contacting the peptide array with a training sample containing one or more molecules of interest. Interactions between the plurality of peptides and the one or more molecules of interest are processed according to a data fitting model, which model is then is applied to interactions between the plurality of peptides and a test sample to predict binding associated with the one or more molecules of interest.

Abstract: A system is provided that considers allele fraction shifts as a function of copy number and clonal heterogeneity. The system leverages differences between allele frequencies to differentiate between somatic and normal variants in impure tumor samples. In solid tumors, stromal cells and infiltrating lymphocytes are typically interspersed among the tumor cells. The normal cell contamination in tumors can be leveraged to differentiate somatic from germline variants. We explicitly model allelic copy number and clonal sample fractions so that we can examine how these factors impact the power to detect somatic variants. The system models the copy number alterations, which can also affect the allele frequencies of both somatic and germline variants. The expected allele frequencies can be calculated. The expected allele frequencies for somatic and germline differ with tumor content for different copy number alterations.

Abstract: Disclosed herein are systems, methods and computer-program products to create synthetic immunohistochemistry (IHC) stained digital slides generated using artificial neural networks (ANNs). In some implementations, the created digital slides can be used as a ground truth to evaluate a method of analyzing IHC stained tissues.

Abstract: Pathogens invade and infect humans. Understanding the infection mechanism is essential for determining targets for new therapeutics. Existing methods provide too many false positive results. A method and system for predicting protein-protein interaction between a host and a pathogen has been provided. The disclosure provides a pipeline for predicting HPIs, which is a combination of biological knowledge-based filters, domain-based filter and sequence-based predictions. Biologically feasible interactions are only possible when both the proteins share common localization and overlapping expression profiles. This observation was used as the first filter to remove biologically irrelevant HPIs. Proteins interact with each other through domains. Both interacting and non-interacting protein pairs provide valuable information about the probability of protein-protein interactions and hence both were used to derive statistical inferences to remove improbable HPIs.

Abstract: Methods of associating a test compound with a compound property. One or more datasets including: for each of a plurality of cell lines and each of a plurality of compounds: for each respective exposure condition: a corresponding response signature for the respective compound in the respective cell line under the respective exposure condition is obtained. A correlation is determined for each unique combination of exposure conditions for a respective pair of compounds based on the corresponding response signature. A weight is determined for each respective pair of compounds based on the determined correlations. A plurality of compound clusters is formed, where each cluster represents compounds that satisfy one or more weight criteria with respect to a particular compound. A compound property of the test compound is determined from properties of one or more compounds in a one or more compound clusters that contain the test compound.

Abstract: Methods, systems, and computer-readable media for multi-domain, multi-modal data segmentation, and automatically generating and refining hypotheses. The method receives data from a plurality of data sources; synthesizing the receive data; identifying trigger event data based on the synthesized data; generating an episode based on a segmentation of the synthesized data and trigger event data; and identifying at least one set of observational features associated with the episode based on the synthesized data and a relevancy metric. The method also includes iteratively generating a hypothesis based on the observational features using machine learning, predicting an outcome based on the hypothesis using machine learning, generating an outcome measure, and validating the hypothesis based on the outcome measure.

Abstract: A system and device for collecting and delivering smoker statistics to an external storage device that accurately describe a smoker's smoking habits.

Abstract: Medical information is communicated between different entities. Personalized models of peoples' understanding of a medical field are created. Role information is used to assign user-appropriate ontologies. More information than mere role may be used for assigning ontologies, such as information on past medical history. The concepts and relationships in different ontologies may be linked, providing a translation from one personalized model to another. The terminology with similar or the same concepts and/or relationships is output for a given user based on their model.

Abstract: A system having patient image processing capability and being in compliance with health insurance portability and accountability act including a N-server having a database, wherein the N-server receives patient data in a form of numerical values from at least one sender and wherein the patient data is converted into numerical values prior to being sent to the N-server. Additionally, the system includes one or more artificial intelligence program to analyze the data in the form of numerical values and detect patterns for a predefined abnormality.

Abstract: The invention relates generally to a system and methods by which a microbiome-based action component may be developed that is useful in order to establish, restore, promote, or maintain subject health. More specifically, the system and methods of the present invention may be used to develop a microbiome-based action component that efficiently summarizes the state of a subject's microbiome along with measures of gut maturity in case of an infant and nutrition readiness in case of an adult subject. Such an efficient summary may be used to render more immediate support or health care to the subject.

Abstract: Described are embodiments of methods and systems for using a removable data storage device to efficiently transfer medical data from a medical device to a remote server. In some embodiments, the medical device tracks transfer statuses of medical data stored on a local storage. A transfer status assigned to a data portion of the medical data may inform the medical device of whether that data portion needs to be transferred, has been transferred, or has been successfully ingested at the remote server. The medical device can use information stored on the removable data storage device in conjunction with the tracked transfer statuses to determine which portions of the stored medical data should be transferred to a physically coupled removable data storage device. After completing a data transfer process, the medical device can update transfer statuses of portions of medical data that was transferred to the removable data storage device.

Abstract: Techniques for tracking a progression of a therapeutic procedure that is performed by a patient are disclosed. A notification is received from a server computer system. This notification relates to a tracking process designed to monitor a progress of the patient in performing the therapeutic procedure. After receipt of the notification, a UI is displayed. This UI has a particular visual layout that is designed to facilitate the tracking process. In response to a particular field being selected within the UI, a secret key that de-identifies the patient is accessed. The accessed secret key and a specific image are then encrypted. As a consequence, encrypted data is generated. The encrypted data is then transmitted to the server computer system.

Abstract: Adaptive on board estimation of exogenous pharmacon responsive to transient (i.e., impermanent) physiological effects is provided. Dynamically estimating an equivalent amount of an exogenous pharmacon on board (XOB), such as insulin and/or carbohydrates, left in the subject, is based on predictions of glucose time-series data. These estimated values, such as insulin on board (IOB), are useful for diabetes management software, including decision support and/or artificial pancreas (AP) algorithms, for example.

Abstract: The example systems, methods, and/or computer-readable media described herein help with design treatment plans for orthodontic treatments. Treatment templates expressed according to treatment domain-specific protocols may be processed to provide treatment planning software, including automated or real-time treatment planning software, that accommodates treatment preferences of a practitioner and/or patient data relevant to a treatment plan. These methods and systems may be also be useful for planning, designing and producing as series of dental appliances (e.g., aligners).

Abstract: The present disclosure relates to a medical image analysis method using a processor and a memory which are hardware. The method includes generating predicted second metadata for a medical image by using a prediction model, and determining a processing method of the medical image based on one of first metadata stored corresponding to the medical image and the second metadata.

Abstract: A processor acquires a radiographic image including a human body and a surgical tool image which indicates a surgical tool and is acquired by a method other than radiography. The processor combines the surgical tool image with the radiographic image to generate a training image for training a discriminator that discriminates a region of the surgical tool in a target image in a case in which the target image is input.

Abstract: An object is to provide an endoscopic image learning device, an endoscopic image learning method, an endoscopic image learning program, and an endoscopic image recognition device that appropriately learn a learning model for image recognition for recognizing an endoscopic image in which a treatment tool for an endoscope appears. The object is achieved by an endoscopic image learning device including an image generation unit and a machine learning unit. The image generation unit generates a superimposed image where a foreground image in which a treatment tool for an endoscope is extracted is superimposed on a background-endoscopic image serving as a background of the foreground image, and the machine learning unit performs the learning of a learning model for image recognition using the superimposed image.

Abstract: The invention provides for a medical instrument (100, 300) comprising: a subject support (110) comprising a support surface (112); a camera system (118); and a signal system (148). The execution of the machine executable instructions (152) cause a processor (142) controlling the medical instrument to: receive (400) a list of selected objects (160) each with a selected coordinate (162); and signal (402) the list of selected objects.

Abstract: A medical services kiosk supporting private and secure telemedicine sessions between a patient and a remote network terminal utilized by a remote health care professional. The medical services kiosk comprising at least one privacy chamber having at least one door and at least one window. Each privacy chamber may include a user interactive display terminal that includes a display device, an input device, and a centralized processor, wherein the centralized processor is electronically communicable with the remote network terminal and a cloud based system. Each patient station may each include at least one documentation receiving device, at least one biometric device for obtaining biometric health measurements of the patient utilizing the at least one patient station, an arm mechanism, a seating mechanism, a camera, a retractable diagnostic camera device, a lighting mechanism that lights the privacy chamber, and a purification system.

Abstract: An information recording device includes: a sensing unit that senses information related to each of a plurality of functions provided in a product; a storage unit that stores usage information related to use of each of the plurality of functions selected or generated from the information sensed by the sensing unit; and an output unit that outputs the usage information stored in the storage unit.

Abstract: Systems, methods and devices for initiating pairing of wireless surgical instruments to a modular energy system are disclosed herein. In various aspects, a modular energy system includes an a radio frequency identification (RFID) reader that is configured to read an RFID card that is uniquely associated with a surgical instrument. When the RFID reader reads the RFID card, the RFID reader initiates a wireless pairing process with the surgical instrument. Initiating the wireless pairing process may include causing the module energy system to wirelessly search for the surgical instrument and causing a display screen to display instructions for wirelessly pairing the surgical instrument.

Abstract: A wearable electronic device, a system and methods of monitoring with a wearable electronic device. The device includes a hybrid wireless communication module with wireless communication sub-modules to selectively acquire location data from both indoor and outdoor sources, as well as a wireless communication sub-module to selectively transmit a cellular-based LPWAN signal to provide location information based on the acquired data. The device may also include sensors to collect one or more of environmental, activity and physiological data. The device may transmit some or all of its acquired data to the system to provide a predictive model to correlate changes in the acquired data to corresponding health, safety or related changes to a wearer of the device. In one form, the predictive health care protocol uses a machine learning model at least some of which may be performed on the device.

Abstract: Provided herein, in some embodiments, are methods for classifying the tandem duplicator phenotype of a tumor into one of at least six TDP subtypes based on the length distribution of tandem duplications (TDs) in the genome of the tumor sample.

Abstract: A system (10) that provides diagnosis support information (110) relating to a disease of a target subject (5) includes: an acquisition unit (11) that acquires subject information (105) including actual image data (15) of an MR image including at least a reference region including part of an evaluation target region of the subject; and an information providing unit (12) that provides diagnosis support information (110) based on pseudo PET image data (115) of the evaluation target region generated by an image processing model (60) machine learned with training data (70) including actual image data (71) of a MR image of a reference region and actual image data (72) of a PET image including the evaluation target region of a plurality of test subjects so as to generate pseudo PET image data (75) of the evaluation target region from actual image data (71) of an MR image of the reference region, from the actual image data (15) of an individual MR image of the target subject.

Abstract: A Predictive Diagnostic Information Capability-Technology (PreDICT™) system (100) enables users including expert and nonexpert users to provide information regarding a condition of a subject and receive timely and accurate information regarding risk stratification, treatment options and other medical evaluation information. The illustrated system (100) generally includes a user device (102) for use by a user assisting a subject (104), a processing platform (108), and a network (106) for connecting the user device (102) to the processing platform (108). The system (100) may also involve an emergency response network (130) that includes public-safety answering points (PSAPs) (132).

Abstract: Systems and methods for identifying a condition of a user. A treatment apparatus is configured to be manipulated by the user for performing an exercise, and an interface is communicably coupled to the treatment apparatus. One or more sensors are configured to sense one or more characteristics of an anatomical structure of the user. A processing device and a memory is communicatively coupled to the processing device. The memory includes computer readable instructions, that when executed by the processing device, cause the processing device to: receive, from the sensors, one or more sensor inputs representative of the one or more of characteristics of the anatomical structures; calculate an infection probability of a disease based on the one or more characteristics of the anatomical structures; and output, to the interface, a representation of the infection probability.

Abstract: Systems and methods are disclosed for processing digital images to identify diagnostic tests, the method comprising receiving one or more digital images associated with a pathology specimen, determining a plurality of diagnostic tests, applying a machine learning system to the one or more digital images to identify any prerequisite conditions for each of the plurality of diagnostic tests to be applicable, the machine learning system having been trained by processing a plurality of training images, identifying, using the machine learning system, applicable diagnostic tests of the plurality of diagnostic tests based on the one or more digital images and the prerequisite conditions, and outputting the applicable diagnostic tests to a digital storage device and/or display.

Abstract: Disclosed is a medical data processing method for determining an indicator relating to an injury of an anatomical structure (1) of a patient, wherein the method comprises executing, on at least one processor (5) of at least one computer (3), steps of: a) acquiring (S1) acceleration data describing an energy of a set of one or more signals in dependence on both time and frequency, the set of signals acquired by measuring the acceleration of the anatomical structure (1) over time; b) acquiring (S2) analysis data describing an analysis rule for determining at least one of b1) an overall energy level of at least one signal of the set of signals, b2) a correlation between at least two signals of the set of signals in the frequency domain, the at least two signals respectively measured at at least two different respective regions of the anatomical structure (1), or b3) a relationship between energies given for at least two different frequency ranges of at least one signal of the set of signals; c) determining

Abstract: Systems and methods for a radar-based viral transmission prevention for a protected space are disclosed. The system comprises a gateway screening system 104 configured for remotely screening subjects crossing a boundary of a protected space, an elevator monitoring system 106 configured for monitoring passengers using an elevator system and a social distance monitoring system 108 configured for monitoring social distancing compliance within the protected space. The system also includes a telemedical monitoring system 110 configured and operable for remotely measuring one or more parameters of a patient using a radar-based system. The system further includes a gesture recognition system 112 configured and operable to identify hand gestures remotely.

Abstract: Methods and systems for providing a secure healthcare communication exchange platform. The methods and systems perform operations comprising: accessing a collection of data records from a plurality of sources, the collection of data records corresponding to a given entity; generating, based on the collection of data records, an aggregated representation of one or more conditions associated with the given entity; determining, based on the aggregated representation, that a given condition of the one or more conditions satisfies an outreach parameter; in response to determining that the given condition satisfies the outreach parameter, triggering an outreach event to communicate with the given entity; generating status information in the aggregated representation, the status information corresponding to the outreach event; and tracking the status information to establish a relationship between the given condition and the outreach parameter.

Abstract: Systems and methods to facilitate adjusting content to facilitate therapeutic outcomes of subjects are disclosed.

Abstract: A sodium-cooled nuclear reactor includes at least one electromagnetic pump assembly and a backflow reduction pipe. The backflow reduction pipe may include an inlet, an outlet, at least one tubular section having a first length and a first diameter, and at least one fluid diode section between the inlet and the outlet.

Abstract: The present application relates to the field of mechanical engineering technologies, and particularly to an unloading device. The unloading device includes a power mechanism, a transmission mechanism, and an execution mechanism that are connected in sequence from top to bottom; wherein the execution mechanism includes a shafting assembly and a turntable assembly that are connected in sequence from top to bottom; wherein the turntable assembly includes an upper auxiliary fence, a middle main disturbance disk, and a lower reclaiming portion that are arranged in sequence from top to bottom. The unloading device provided by the present application is easy to control, and ensures the reclaiming reliability of the spherical materials and the stability of the sphere flow unloading, which can meet the requirements of long life and reliable operation of the unloading device under light load and low speed working conditions and achieve the convenient maintenance.

Abstract: A telescopic lead blanket lifting frame and method for shielding workers from a radiation source. The lifting frame includes, first and second hollow vertical tubular members attached orthogonally on first ends thereof to first and second ends of a horizontal base member. Third and fourth vertical tubular members and slidably disposed in the first and second hollow vertical tubular members. A first cross member is attached orthogonally to second ends of the first and second hollow vertical tubular members. A second cross member is attached orthogonally to distal ends of the third and fourth vertical tubular members. A plurality of hooks are attached to the first and second cross members on side portions thereof for engaging lead blankets. A lifting gear is provided for telescopically extending and retracting the third and fourth vertical tubular members and second cross member in a vertical direction.

Abstract: A method for stabilizing a neutralization slag of uranium associated zirconium and zirconia, and a stabilization agent used therein are disclosed. The stabilization agent includes the following components in parts by weight: a pretreatment agent of 2-8 parts, anhydrous calcium chloride of 2-6 parts, an adsorbent of 3-5 parts and a stabilizer of 4-9 parts. The stabilization agent is used to stabilize the uranium that is existed in the neutralization slag in a waste slag. The method includes the following steps: the pretreatment agent is used to alkalize and disperse the neutralization slag; soluble calcium salt is added to cement the neutralization slag; and the adsorbent and the stabilizer are used as a composite material to passivate the neutralization slag. The method has low cost, fast effectiveness, simple process, easy operation, and long-term stable remediation efficiency, which can be applied to the treatment and disposal of associated radioactive waste residues.

Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.

Abstract: An antioxidant conductive thermal paste and a method of manufacturing the same are provided. The antioxidant conductive thermal paste includes a reactive monomer, a thermosetting resin, a polymerization inhibitor, an electrically conductive filler, and a thixotropic agent. The method consists of the steps of mixing a reactive monomer, a thermosetting resin, and a polymerization inhibitor evenly to get a first polymer mixture, and adding an electrically conductive filler and a thixotropic agent into the first polymer mixture in turn and blending the mixture evenly to obtain an antioxidant conductive thermal paste with good adherence, high electrical conductivity, high thermal conductivity, improved thermal-mechanical fatigue resistance or mechanical fatigue resistance.

Abstract: A method of coiling a superconducting cable, where the superconducting cable is comprised of a plurality of stacked superconducting tapes, where the superconducting cable has a clocking feature that identifies an orientation of the superconducting tapes, the method comprising the step of orienting coils of the superconducting cable, such that a magnetic field from surrounding coils impinge upon a given coil at a desired angle, based upon an orientation of the clocking feature.

Abstract: A superconducting cable (1) includes a superconducting cable core (2) and a corrugated pipe (21) storing the superconducting cable core (2). The superconducting cable core (2) has a corrugated pipe (11), a superconductor (12) provided on the outer peripheral side of the corrugated pipe (11), and a heat insulating pipe (23) stored in the corrugated pipe (11) and having a smooth inner peripheral surface. A coolant flows through a flow passage (FP1) formed in the heat insulating pipe (23) and then flows through a flow passage (FP2) formed between an outer peripheral surface of the corrugated pipe (11) and an inner peripheral surface of the corrugated pipe (21).

Abstract: A coaxial cable includes an inner conductor having one center wire, and six outer wires stranded around the center wire, an insulator covering an outer periphery of the inner conductor, and a shield conductor covering an outer periphery of the insulator, wherein, in a cross section perpendicular to a longitudinal direction of the coaxial cable, a ratio of a total area of first regions which are respectively formed by a gap between the center wire and two adjacent outer wires, with respect to an area of a circumscribed circle of the inner conductor, is 0.5% or higher and 2.0% or lower, and a ratio of a total area of second regions which are respectively formed by a gap between surfaces of the two adjacent outer wires and a surface of the insulator, with respect to the area of the circumscribed circle of the inner conductor, is 2.0% or higher and 5.0% or lower.

Abstract: A torque transfer assembly comprising a drive shaft and a driven shaft and a dielectric insert arranged to be positioned between the drive shaft and the driven shaft, the insert assembly comprising a body of dielectric material shaped to form an insulating layer and configured to engage, respectively, with a first shaped engagement feature on the drive shaft and a second shaped engagement feature on the driven shaft, in torque transfer engagement, the insulating layer providing a dielectric barrier between the drive shaft and the driven shaft.

Abstract: Power umbilical (1) comprising a plurality of power cables (7) for electric power transmission, elongated filler elements (5), and an outer sheath (3). The elongated filler elements (5) abut against each other at abutment faces (5a), thereby forming a complete ring enclosing the power cables (7). The elongated filler elements (5) comprise cable recesses (5b) within which the power cables (7) are embedded. The power umbilical (1) further comprises one or more friction control profiles (13, 15, 116), wherein the material of the friction control profile (13, 15, 116) is softer than the material of the elongated filler elements (5). The one or more friction control profiles (13, 15) are arranged in a deformed state.

Abstract: A method for preparing a sintered magnet is provided according to one embodiment of the present disclosure. The method includes preparing a mixed powder by coating fluorides on a surface of magnetic powder, adding heavy rare earth hydrides to the mixed powder, and heating the mixed powder, wherein the magnetic powder includes rare earth element-iron-boron-based powder, and the fluorides include at least one of an organic fluoride or an inorganic fluoride.

Abstract: An inductor includes a coil having a winding portion, and a pair of lead-out portions extended from the winding portion; a body containing the coil and including a magnetic portion, the magnetic portion including metallic particles and a first resin; and a pair of outer electrodes on a surface of the body. The body has a metallic-particle exposed region on its surface. Each outer electrode includes a conductive resin layer, and a first plating layer on the conductive resin layer. The conductive resin layer is disposed on at least the metallic-particle exposed region. The first plating layer includes a first covering region covering the conductive resin layer, and a first extending region continuous to the first covering region and extending to at least the metallic-particle exposed region. The first plating layer is connected with at least a portion of the metallic particles on the metallic-particle exposed region.

Abstract: Radio frequency filtering circuitry blocks certain frequencies in an outgoing signal so that the signal may be transmitted over a desired frequency. The radio frequency filtering circuitry includes a first inductor having a first coil and a second inductor coupled to and disposed within the first coil. The second inductor has a second coil and a third coil symmetrical to the second coil. When current is applied to the radio frequency filtering circuitry, the current in the second coil causes a first induced current in the first coil and the current in the third coil causes a second induced current in the first coil, wherein the second induced current is approximately equal in magnitude and opposite in direction to the first induced current. As such, the second induced current may compensate for the first induced current.

Abstract: The coil component includes a magnetic body containing a metallic material and a resin material, a coil conductor embedded in the magnetic body, and a pair of outer electrodes electrically connected to ends of the coil conductor. The coil conductor includes an exposed portion at each end portion of the coil conductor, and a covered portion covered with an insulating substance disposed between the exposed portions. The covered portion is disposed inside a face of the magnetic body on which the outer electrodes are disposed.

Abstract: A first dimension of each of a first connection portion 12 and a second connection portion 14 in the direction in which a pair of side surfaces 2e and 2f face each other is smaller than an inner diameter W2 of a coil 8 in the direction and is larger than a width W1 of each of a plurality of coil conductors in the direction. A second dimension of each of the first connection portion 12 and the second connection portion 14 in the direction in which a pair of main surfaces 2c and 2d face each other is larger than a thickness H1 of each of the plurality of coil conductors in the direction and is smaller than a height H2 of the coil 8 in the direction.

Abstract: A magnetic-component module includes a substrate, a core on a first surface of the substrate, a spacer on the core, a gap between a bottom surface of the core and the first surface of the substrate, a winding including wire bonds extending over the core and electrically connecting a first portion of the substrate and a second portion of the substrate, and traces on and/or in the substrate, and an overmold material encapsulating the core, the spacer, and the wire bonds and filling the gap.