Abstract: A Huber safety needle assembly including a body, configured to receive a needle. The body further including an upper portion having a first gripping portion coupled thereto, a lower portion having a second gripping portion coupled to thereto, and a hinge mechanism. The needle having a needle tip configured to be received in the body. The hinge mechanism is configured to operably transition the body between a closed configuration and an open configuration. The closed configuration allowing at least a portion of the needle, including the needle tip, to extend below the bottom surface of the lower portion of the body. The open configuration allowing the needle tip to be securely received within the lower portion such that it does not extend below the bottom surface of the lower portion.

Abstract: A device for performing injections in a patient includes a syringe holder with a needle guard, a cannula extending from the syringe holder, a needle slidably disposed over the cannula, and a slider on the syringe holder. The cannula has a blunt tip and a cannula length, and the needle has a sharp tip and a needle length that is shorter than the cannula length. The slider is coupled with the needle and is configured to slide the needle along the cannula from an extended position, in which the sharp tip of the needle is located at or immediately adjacent the blunt tip of the cannula, to a retracted position, in which the sharp tip is housed within the needle guard of the syringe holder.

Abstract: A sheath assembly for use with an elongated needle may include an elongated body portion configured to slidably receive the elongated needle therein, wherein the elongated sheath includes a top surface, a bottom surface, a proximal end, a distal end, and at least one joint portion formed adjacent or proximate the distal end of the sheath. Preferably, at least one joint portion is disposed adjacent or proximate the distal end of the sheath so that a bend in the elongated sheath at least one joint portion produces a corresponding bend in the needle. As such, the needle remains in the sterile environment of the sheath during the bending process, the sheath protecting the physician from needle pricks.

Abstract: Disclosed herein are puncturing devices and puncturing systems including the puncturing devices. Such puncturing devices and systems include those that sense a difference between venous blood and arterial blood as a function of blood oxygen, impedance, or pressure. As a result, the puncturing devices and systems are able to differentiate between a venipuncture and an arterial puncture. Methods of the puncturing devices and systems for differentiating between a venipuncture and an arterial puncture are also disclosed.

Abstract: A syringe includes a barrel having first and second ends, with the barrel defining an interior space and a stopper positioned therein, the stopper moveable within the interior space relative to the barrel, a plunger connected to the stopper, and a collar having threads configured to engage threads of a medical connector. The collar is at least partially received by the barrel, with one of the barrel and the collar defining a slot and the other of the barrel and the collar having a pin received within the slot. The collar has a connection position where the collar is fixed relative to the barrel when the syringe is being connected to the medical connector, a disconnection position where the collar is fixed relative to the barrel when the syringe is being disconnected from the medical connector, and a reuse prevention position wherein the collar is rotatable relative to the barrel.

Abstract: A device, for delivery of aerosolized drug in a portion of a body, comprising: a nozzle (100) comprising a head portion extending, distally, into an elongate shaft (108), said head portion comprising: piezoelectric transducers (104, 106) mounted between electrically conductive electrode discs (103, 105), said piezoelectric transducers (104, 106) creating capillary waves in a liquid film causing atomization of drug/s while passing through said nozzle (100); an aperture (101) on said nozzle (100), through which tubing (112) is connected, said aperture (101) follows through with a passage (300) ensconced in said elongate shaft (108), and passing through said piezoelectric transducers (104, 106) and said electrically conductive electrode discs (103, 105) in order to allow passage of drug received through said tubing (112); and said elongate shaft (108) supporting a body member (107) at its operative proximal end and having an opening (109), said drug being dispensed through said opening (109).

Abstract: A method includes applying an actuating voltage to a solenoid for a first time span to actuate the solenoid against a bias. The method includes lowering voltage applied to the solenoid to a holding voltage that is lower than the actuating voltage to hold the solenoid against the bias for a second span of time. The solenoid has a coil to which the actuating and holding voltages are applied. The coil is rated for continuous operation at a rated voltage. The actuating voltage is above the rated voltage.

Abstract: An attachable adherence monitor that may be attached to different types of medicant dispensers is disclosed. The adherence monitor has a sensor body including sensing electronics that are triggered to indicate the activation of a medicant dispenser and assign a timestamp to the activation. The sensor body includes a storage device storing data indicating the activation of the medicant dispenser. The sensor body includes a connector conduit. A number of attachment modules are provided. Each of the attachment modules includes a connector that allows attachment to the sensor body via the connector conduit. A first attachment module includes a first attachment mechanism for attaching the sensor body to a first medicant dispenser. A second attachment module includes a different second attachment mechanism for attaching the sensor body to a second different medicant dispenser.

Abstract: Provided herein are dry powder formulations comprising epinephrine alone or in combination with at least one enabling agent suitable for nasal application. Also provided are unit dose forms and devices comprising such formulations and methods of using such formulations for the treatment of various conditions including anaphylaxis, anaphylactoid reaction, respiratory conditions, hemodynamic collapse, and for administration during cardiopulmonary arrest and other life-threatening conditions.

Abstract: What is proposed is a nasal dispenser (10) for the nasal application of liquids in atomized form, in particular for children. The nasal dispenser (10) has a nasal applicator (40) which is for dispensing the liquid and is formed by an outer component and an inner component, which together define a vortex chamber and at least one inlet channel into the vortex chamber. In the case of components that are stationary in relation to one another, especially tapered inlet channels (96) for generating a high liquid velocity in the vortex chamber (98) are proposed. The cross-sectional area of the inlet channel (96), that is aligned transversely to the flow direction (4) in the inlet channel, at its narrowest point or the sum of the cross-sectional areas of the inlet channels, that are aligned transversely to the flow direction (4) in the inlet channels (96), at their respective narrowest points is at most 0.05 mm2.

Abstract: The present invention relates to a system for indicating an at-risk situation for a lung ventilator, comprising a screen (1) that displays at least one fixed-size drawing element (2) representing the lungs being ventilated, in which the shade of the drawing element switches according to predetermined criteria.

Abstract: The present disclosure relates generally to medical ventilators, and more particularly to systems and methods for detecting and quantifying patient-ventilator asynchrony. In an example, a processor receives ventilation data from a medical ventilator and outputs a data dashboard on a display screen. The data dashboard displays a detection of first and second different types of patient-ventilator asynchrony events in the ventilation data. The data dashboard also includes time-scaled asynchrony metrics organized into tiles for each of the first and second asynchrony events.

Abstract: Systems and methods provide transferring of access to patient data between organizations. In some implementations, one or more servers, with various services (12, 14, 16, 18, 20), transfer access to patient data from a first to a second organization. The server(s) may generate a user interface; receive job input data via the interface; and generate a transfer job based on the job input data. The transfer job may include list data indicative of one or more patients. The server(s) may execute the generated transfer job. The executing iterates through the list data and communicates transfer commands to services of the server(s). Access to the patient data associated with the patient(s) of central database(s) indicated by the list data is transferred from the first organization to the second organization. The server(s) may generate, for a display on the user interface, transfer job status information concerning the status of the executing.

Abstract: A laryngeal mask airway device (LMA) is disclosed comprising a ventilation conduit having operatively upper and lower ends, and a mask at the operatively lower end of the ventilation conduit. The mask has an inner surface forming a receptacle that is in fluid communication with the ventilation conduit, and an outer oropharyngeal surface facing away from the receptacle. The device includes a separate oropharyngeal suction conduit having an operatively lower end forming a collector defining a plurality of suction openings that extends across the oropharyngeal surface of the mask. In use secretions may be drawn through the suction openings into the oropharyngeal suction conduit for removal from the patient through the oropharyngeal suction conduit.

Abstract: A speech valve for placing and fitting on a tracheostomy cannula, having a throughflow body enclosing a throughflow channel which on one side at one end has a connection for joining to a proximal end of the tracheostomy cannula, a one-way valve located at an end of the throughflow body opposite the connection, and, at a distance along the throughflow channel between the connection and the one-way valve, a valve opening is located which is closable by an overpressure valve. The overpressure valve arrangement has at least one elastically deformable valve flap which, in a first state covers the valve opening provided between the connection structure and the one-way valve on the throughflow body and, at a predefinable overpressure occurring inside the throughflow channel converts, by an overpressure-driven elastic deformation of the valve flap, to a second state, in which it at least partially exposes the valve opening.

Abstract: A device combining a treatment of ear and sinus conditions along with speech therapy and administration of medication is disclosed. The device comprises a patient facemask, adapted to cover mouth and nose of a patient, and a visual and/or audio feedback mechanism connected to the facemask and adapted to provide feedback through internal air pressure in a device's compartment. The device's compartment is adapted to be in fluid communication with the patient mouth and nose during its operation. The device may comprise a supervisor facemask. Expiration into the facemask(s) increases air pressure. An increase in air pressure within the device activates the feedback mechanism and will lead to effective middle ear and sinus ventilation. The feedback mechanism may also be used in speech therapy for feedback to the patient. Drugs may be administered into the system for treatment of airway disease of for the purpose or general anaesthesia.

Abstract: A patient interface system to treat a respiratory disorder of a patient, the patient interface system comprising: a positioning and stabilising structure including a back portion and a pair of upper straps extending from the back portion; and a patient interface including a patient interface frame and a pair of rigidiser arms each connected to the patient interface frame at a connection point located in a plane substantially parallel to the patient's Frankfort horizontal plane, the pair of rigidiser arms further including a pair of upper attachment points, wherein the pair of upper straps are adapted to be releasably attached to the pair of upper attachment points such that, when donned by the patient, the pair of upper straps are vertically offset relative to the upper attachment points and substantially parallel to the patient's Frankfort horizontal plane, and wherein the patient interface does not include a forehead support.

Abstract: A patient interface including a plenum chamber, a first seal-forming structure for forming a seal around the patient's mouth, and a second seal-forming structure for forming a seal around the patient's nares. The patient interface further includes at least one stopper rib disposed in the cavity of the plenum chamber spaced apart from the first seal-forming structure in a rest position. The first seal-forming structure configured to contact the at least one stopper rib in an operational position. The at least one stopper rib configured to oppose compression of the first seal-forming structure in an anterior direction. The second seal-forming structure is not configured to contact the at least one stopper rib.

Abstract: A patient interface to provide breathable gas to a patient, comprising: a plenum chamber assembly, comprising: a nasal plenum chamber at least partly defining an upper gas chamber; an oral plenum chamber at least partly defining a lower gas chamber; and a decoupling structure at least partly connecting the nasal plenum chamber and the oral plenum chamber and at least party defining a flow path; a top plate including at least one connection feature configured to releasably retain a first portion of a positioning and stabilising structure; and a faceplate configured to releasably retain a second portion of a positioning and stabilising structure.

Abstract: Nasal cannula assemblies for providing respiratory therapy to patients are provided. A nasal cannula assembly can include a cannula, an optional manifold which may be removable, a gas supply tube, and a securement mechanism. Securement mechanisms can include headgear straps, cheek pads, or an adhesive nose strip. A nasal cannula assembly can also include a lanyard, lanyard clip, and/or lanyard connector to help support the weight of a main gas delivery conduit.

Abstract: A connector for connecting with an absorber canister includes a first connector port for detachably communicating with an input port of the absorber canister; a second connection port for detachably communicating with an output port of the absorber canister; and a seal. The seal being sleeved on a sidewall of a at least one connection port of the first connection port and the second connection port, and the seal including: an annular ring positioned on an outer sidewall of the at least one connection port; a guide chamfer portion, the guide chamfer portion being annular and extending obliquely from a bottom of the annular ring towards an interior of the at least one connection port; and a lip, the lip being annular and extending from an end portion of the guide chamfer portion in a direction towards or away from the annular ring.

Abstract: An integrated oxygen supply device that is configured to generate oxygen continuously and release the oxygen non-continuously is provided. In some embodiments, the oxygen generated by the integrated oxygen supply device is stored in a porous material with the integrated oxygen supply device. The delivery of the oxygen produced by integrated oxygen supply device to a patient, in those embodiments, is controlled. In some embodiments, the control of the delivering oxygen is according one or more breathing patterns. The breathing pattern(s) may or may not be a current breathing pattern of the patient. For example, in one embodiment, the breathing pattern is a predetermined breathing pattern with a specified inspiration period followed by a specified expiration period.

Abstract: A portable oxygen concentrator designed for medical use where the adsorbent beds, are designed to be replaced by a patient. The concentrator is designed so that the power supply and adsorbent bed mount is one module and the compressor and air filter are part of another module configured to provide a unitary cooling and air supply system. Replacement beds may be installed easily by patients, and all gas seals will function properly after installation.

Abstract: An HME device (1) has an outer housing (10) in two parts removably connected with one another by bayonet lugs (17) on one part (13) inserted in bayonet slots (48) on the other part (14) and twisted. An HME unit (50) has a tapered coupling at one end fitted on an internal port (45) in one part (14) so that it can be removed and replaced by separating the two parts of the housing. The outside of the HME unit (50) is spaced from the inside of the housing (10) by an annular bypass channel (55). A selector (31) has a rotatable plate that can be moved to cover either the passage through the HME unit or the bypass channel.

Abstract: Improved respiratory treatment systems are described e.g. for treatment of respiratory diseases and provision of respiratory therapy, together with components therefor. In one form, the technology relates to a positioning and stabilizing structure which includes a first headgear tube, a second headgear tube and a flow regulator. A flow regulator is provided to adjust the proportion of flow of respiratory gas to the first headgear tube and the second headgear tube. In another form, the technology relates to a patient interface configured to adjust the proportion of the supply of breathable gas that flows from a first flow path to a patient's first naris and from a second flow path to the patient's second naris. In yet a further form, the technology relates to improves conduits for respiratory treatment systems.

Abstract: The present application provides a light-assisted sleep and wake-up alarm clock and a wake-up method thereof, and relates to the field of human biological sleep. The light sleep aid and wake-up alarm clock comprises an alarm clock and a sleep monitoring device, a light-emitting unit is arranged on the front of the alarm clock, a timer is arranged in the middle of the alarm clock, and a control module is arranged inside the alarm clock and a control mainboard is electrically connected with the light-emitting unit and the timer, a wireless receiving module is also arranged on the control mainboard, a wireless sending module is arranged inside the sleep monitoring device, and the wireless sending module is wirelessly connected with the wireless receiving module, and a sleep aid module and a sleep detection module are also arranged inside the sleep monitoring device.

Abstract: A method for treating a person suffering from a negative psychologic reaction when a past traumatic event is recalled, the method comprising: (a) accessing clinical data of a person's mental state relating to the event causing the negative psychologic reaction; (b) creating a mixed reality (XR) environment for the person, the XR environment comprising at least a display; and (c) presenting sequential content on the display over a period of time, wherein the sequential content comprises multiple depictions of the event at increasing levels of immersion, including an initial depiction of the event at an initial immersion level, and a final depiction of the event at a final immersion level, wherein the final immersion level is the highest immersion level in the XR environment.

Abstract: A device for carrying out a relaxation treatment on the forehead of a person by producing a continuous liquid stream the device including an outlet nozzle for forming the liquid stream; a liquid reservoir; a sliding unit for reciprocating movement of the outlet nozzle in a lateral direction; at least one circulation pump; a pipe system connecting the outlet nozzle and/or the liquid reservoir with the circulation pump; and a housing. In order to simplify the use of the device, which is readily transportable and can be used without special knowledge of the treatment, it is provided that the housing has a base housing element and a top housing element wherein the top housing element is pivotally connected to the base housing element so that the device can be brought from a collapsed transporting state to an opened operating state.

Abstract: A sleep-inducing electronic device, for being in skin contact with a user to operate, includes an input unit with first and second sensors detecting physiological signals of the user. A processor unit operatively connects to the sensors to receive the detected physiological signals therefrom and monitors at least one physiological parameter from a parameter group consisting of an electromyogram (EMG) signal and a galvanic skin response (GSR) signal. The processor unit converts the at least one physiological parameter into light stimulus signal parameters. An output unit connected to the processor unit to receive the light stimulus signal parameters therefrom produces a corresponding light stimulus signal for the user.

Abstract: One or more aspects of a sleep environment of a sleep platform for a user may be set or modified based on at least some sleep environment information for sleep platforms of other users. The other users may have similar characteristics as the user. The aspects of the sleep environment may be set or modified based on one or more aspects of sleep environments of sleep platforms of the other users indicated as providing improved sleep quality. The sleep environment of the sleep platform may include sleep surface conditions and/or conditions surrounding the sleep surface.

Abstract: A system and method for cloud-based gaming with health-related telemetry operates a game that entertains the user while simultaneously capturing data about the user's physical and mental performance which can later be used to diagnose medical conditions and, depending on configuration, implement treatment regimens comprising exercise routines and mental simulation via tasks in the gaming environment.

Abstract: A method, system and apparatus for treatment of pain which stimulates one or more of the five senses to reduce pain in a human. The five senses being visual (eyes), auditory (ears), olfactory (smell), gustatory (taste), and tactile (touch). The apparatus of the invention preferably uses a headset having an audio and video system along with a scent delivery device, food/tastants, and a haptic device to stimulate one or more of the five senses of the human.

Abstract: A drainage spigot guard may be configured to disinfect a spigot from a urinary catheter. The drainage spigot guard may include a shell with an interior cavity shaped to receive the spigot. The drainage spigot guard may further include a first disinfectant swab within the interior cavity. The first disinfectant swab may be positioned to disinfect at least part of the spigot in response to insertion of the spigot into the interior cavity. The shell may have an exterior shape configured to be received within a spigot retainer on a urinary catheter bag attached to the spigot.

Abstract: The invention provides an improved indwelling urinary catheter of the inflatable type having a unique, low profile device by which to retain the catheter within the bladder, so that urine can be removed therefrom while avoiding obstruction to the descending fetal vertex during the process of labor and delivery, Thus, making it better suited for obstetrical applications. The retaining device consumes less obstructing volume in the bladder than that which would ordinarily be consumed by a conventional Foley-style balloon, whereby both the frequency and severity of fetal vertex obstruction and its resulting increased time of labor, operative delivery and injury to maternal urologic tissue can be reduced. The obstetrical Foley retains the tradition Foley-style balloon distal to the improved low-profile laboring balloon for insufflation in the event a surgical delivery by cesarean section is indicated.

Abstract: An intermittent urinary catheter assembly comprises a catheter having a proximal insertion end and a distal end opposite to the proximal insertion end. The catheter has a lumen extending from a drainage opening at or near the proximal insertion end to a discharge opening at or near the distal end. Further, a protective sleeve arrangement is provided, having a proximal holder part, a distal holder part and a compactable sleeve connected to the proximal holder part and the distal holder part. The compactable sleeve has a compacted storage configuration and is extendable into an expanded configuration. The distal holder part is connected to the catheter at or near the distal end, and the proximal holder part and the distal holder part are releasably connected to each other.

Abstract: The present disclosure is enclosed in the area of multi-way bladder catheters, which are suitable for draining urine and/or blood and/or instillation liquid from the bladder of a patient. It refers to a bladder catheter (1) with a drainage outlet (5), a drainage channel (11) and drainage inlets (4), the drainage channel (11) connecting the drainage outlet (5) and the drainage inlets (4), and an instillation inlet (2), a branched channel (12) and more than one instillation outlets (3), the branched channel (12) having a portion with a single way connecting to the instillation inlet (2) and several portions each connecting to the instillation outlets (3), wherein the portion with a single way is furcated to each of the several portions connecting to an instillation outlet (3), such that instillation liquid injected in the instillation inlet (2) is furcated and ejected from each of the instillation outlets (3). It guarantees that no change of procedure is required for a practitioner, in a simplified manner.

Abstract: The invention relates to a tube device (100), in particular a lock-type device for insertion in a body lumen, that can be reversibly stiffened under the effect of pressure by a concentric arrangement of an inner (1) and outer tube (4), and a stiffening layer (3), the stiffening layer exerting pressure on the outer tube and thus producing high friction.

Abstract: The invention relates to medical technology, and more particularly to multipurpose extension catheters. A multipurpose extension catheter configured in the form of an elongate flexible body with a through-channel thereinside has a rectilinear proximal part and a straight or bent distal part for entering the aorta, the distal end of the guide catheter terminating in a soft tip. The curvature of the distal part of the catheter is in keeping with standard types of guide catheters, which correspond to the dimensions of the aortic arch and the type of origin of the coronary arteries and peripheral vessels.

Abstract: Balloon based therapy devices for treatment of diseased vessels are described. The devices are adapted for active aspiration of a closure zone prior to delivery of a closure agent. The devices may be used for treatment of diseased veins in the lower limbs and pelvis.

Abstract: An intravenous catheter securement sleeve includes a protective cover for placement over a bodily appendage, the protective cover having an opening configured to permit visual of the insertion site of an intravenous catheter on the bodily appendage. A flap is connected to the protective cover and is movable between an open position in which the opening is visually exposed and a closed position in which the opening is concealed. The intravenous catheter securement sleeve further includes at least one monitoring device connected to protective cover and configured to detect at least one functional parameter, and at least one remedy device connected to the protective cover and configured to administer a remedy.

Abstract: A protective cover for an affected area of a patient, particularly associated with an insertion site of a catheter or other puncture or opening in a patient's skin, comprising a body portion including an aperture, and a window portion, wherein the body portion and window portion each optionally comprises an antimicrobial composition. Aspects of the present invention provide articles, systems and kits for covering an incision, wound or catheter insertion site with a protective cover, and methods of using and making the protective cover.

Abstract: A catheter assembly configured for use with a medical device is provided herein. The catheter assembly can comprise a catheter hub having an interior chamber and a valve located in the interior chamber. The valve can comprise a distal portion, a proximal portion, and a sidewall extending therebetween to define a valve interior. The valve can include a barrier layer having a concave shape that extends in the valve interior from the sidewall at the distal portion. The barrier layer can have at least one slit extending therethrough that is in a normally closed configuration to prevent a fluid from passing through the barrier layer. The catheter assembly can further comprise a sealing ring located circumferentially at a distal end of the valve distally to the barrier layer. The sealing ring can form a seal between the valve and the interior chamber at the distal end.

Abstract: A vasculature navigation system may include a dilator having a proximal end and a distal end located opposite the proximal end, the dilator comprising a guidewire lumen extending between the proximal end and the distal end, the dilator defining a proximal portion and a distal portion located opposite the proximal portion. In some embodiments, the vasculature navigation system also includes an access port located at the proximal end of the dilator, a distal port located at the distal end of the dilator, and a hemostasis valve coupled to the proximal portion of the dilator. The hemostasis valve may be configured to control fluid flow between the proximal portion and the distal portion. In some embodiments, a flush port is coupled to the proximal portion of the dilator and located distal to the hemostasis valve, and the flush port is coupled to a fluid supply source.

Abstract: Provided is a balloon for a balloon catheter that is easy to insert in a body cavity, has good pushability, and can easily incise a stenosis. A balloon for a balloon catheter, having a balloon body (20), the balloon body (20) having a protrusion part (60) that projects outwardly in the radial direction y from its outer surface in the straight tubular part (23) and the proximal tapered part (22), wherein a ratio W1/H1 of a height H1 of the protrusion part (60) and a width W1 of the protrusion part (60) in the straight tubular part (23) is greater than a ratio W2/H2 of a height H2 of the protrusion part (60) and a width W2 of the protrusion part (60) in the proximal tapered part (22).

Abstract: In some aspects, catheter devices can include: a reinforcing member having a proximal and distal ends, the reinforcing member comprising: discrete longitudinally arranged structural regions between the proximal and distal ends comprising: a first, proximal, structural region defining a first series of wall perforations that generate structural properties within the first structural region, the first series of wall perforations setting a first stiffness of the first structural region; and a second structural region, disposed distally relative to the first structural region, defining a second series of wall perforations that generate structural properties within the second structural region, the second series of wall perforations setting a second stiffness of the second structural region, which is less than the first stiffness, wherein the second series of wall perforations differs from the first series of wall perforations by at least one of: cut balance, cut frequency, or pitch.

Abstract: An apparatus of an elongated cylindrical shape, which is inserted into the anal canal and expands progressively in segments, beginning with the distal end positioned in the rectal chamber, and finishing at or near the anal verge at the proximal end. Expansion is gradually increased by the user as directed, and then decreased to its original dimensions, with a purpose of conditioning the anus for insertion of desired objects.

Abstract: Disclosed is an arterial access sheath for introducing an interventional device into an artery. The arterial access sheath includes an elongated body sized and shaped to be transcervically introduced into a common carotid artery at an access location in the neck and an internal lumen in the elongated body having a proximal opening in a proximal region of the elongated body and a distal opening in a distal region of the elongated body. The internal lumen provides a passageway for introducing an interventional device into the common carotid artery when the elongated body is positioned in the common carotid artery. The elongated body has a proximal section and a distalmost section that is more flexible than the proximal section. A ratio of an entire length of the distalmost section to an overall length of the sheath body is one tenth to one half the overall length of the sheath body.

Abstract: An urethral antimicrobial delivery device (1) comprising; a deformable reservoir (101) in fluid connection with an elongate member (102), the elongate member comprising a lumen, the elongate member having a proximal end and a distal end, the elongate member having a plurality of pores (103) defined therein, said pores being distributed along a length of said elongate member, the elongate member being dimensioned for insertion through an external urethral orifice of a female subject, whereby the elongate member is insertable into a distal urethral cavity for delivery of at: antimicrobial in said distal urethral cavity, and wherein the device comprises a collar (105) to prevent said elongate member entering a proximal urethral cavity.

Abstract: Embodiments herein relate to an implantable device comprising a casing, a semi-permeable membrane plug at or near a first end of the casing, a piston, beads, and an opening for release of the beads from the implantable device within a body of a human or an animal; wherein the implantable device is configured to be implanted within the body of the human or the animal during delivery of the beads into the body of the human or the animal; wherein the beads comprise a core and a shell with the core being enclosed by the shell and the beads contain a drug; and wherein the implantable device is configured to produce a desired flow rate of elution of the drug from the implantable device when the implantable device is implanted within the body of the human or the animal.

Abstract: A swallowable oral drug delivery device comprises: a driving part including an actuator, and a cylinder linearly moving by means of the actuator; a drug accommodation part including a first chamber for accommodating a piston linked with the cylinder to linearly move and an inactivated first drug, a second chamber for accommodating a second drug activating the first drug, a separation membrane for isolating the first chamber from the second chamber, and an outlet membrane for closing an outlet allowing either the first chamber or the second chamber to communicate with an external environment; a sensing part for identifying the movement or position of the drug delivery device; and a control part for receiving a signal provided from the sensing part, and controlling the operation of the actuator on the basis of the signal.