Abstract: This disclosure concerns expandable devices, specifically self-deployed devices, for adherence to a tissue, for example intestinal tissue. The disclosure also concerns expandable devices, specifically self-deployed devices for delivery of at least one active agent to, or across, a tissue.

Abstract: The present disclosure describes microneedle array compositions comprising a plurality of microneedles projecting from a substrate. Each microneedle of the plurality of microneedles comprise a penetrating tip and a base that is integrally connected with the substrate, wherein each microneedle of the plurality of microneedles is a porous microneedle composed of a degradable hyaluronic acid polymer comprising a disulfide bond.

Abstract: A system, apparatus and method for a tightly sealed, low moisture vapor transmission, low relative humidity headspace atmosphere aseptic vaccine delivery with low particulate generation. The system can include a housing, desiccant and a biasing member designed to quickly and efficiently deliver medicament to a patient.

Abstract: We describe an improved conductive biocompatible scaffold for electroporation. The biocompatible scaffold comprises biocompatible material (e.g., collagen and/or other extracellular matrix) and incorporates a metal or polymer network or dispersion that conducts an electrical current through the scaffold. The material can adsorb or trap or bind nucleic acids (e.g., RNA or DNA), nanoparticles, proteins and/or small molecules; subsequently cells are placed in proximity to or in contact with the scaffold and an electrical current passed through the scaffold, thereby facilitating cellular entry of the nucleic acids, nanoparticles, proteins and/or small molecules, particularly into those cells that are in proximity of the scaffold.

Abstract: Described herein is an apparatus, comprising a substrate having a top surface and a bottom surface. In an embodiment, the apparatus comprises one or more piezoelectric transducers having a diameter of about 10 mm and a thickness of about 2 mm, embedded in the substrate. In an embodiment, the apparatus comprises one or more cavitation chambers having a depth of about 1 mm, each of the one or more cavitation chambers disposed between respective ones of the one or more piezoelectric transducers and the top surface of the substrate, wherein the one or more piezoelectric transducers generate vibrations within a frequency range about 20 kHz to about 1 MHz in the cavitation chambers that cause a substance stored in the cavitation chambers to be forcibly moved through the top surface of the substrate.

Abstract: Embodiments disclosed herein are directed to a stabilization device (100) configured to engage a subcutaneous medical device, or port (40). The device can include a guide cylinder (120) that aligns with a receiving cup (46) of the port when the port is engaged with a bottom surface (116) of the stabilization device. The guide cylinder can be rotatable between a first position and a second position. The guide cylinder can further include a needle channel (122) extending therethrough. An axis of the needle channel can be offset from the central axis of the guide cylinder. As such rotating the guide cylinder between the first position and the second position can align the needle channel with a different insertion site. The needle channel can align with the receiving cup of the port in both the first position and the second position. Accessing the receiving cup through different insertion sites can mitigate the formation of scar tissue.

Abstract: A connecting system for medical applications, which can be used in medical technology, particularly in the field of oncology, includes a male connector and a complementary female connector. The male connector has a plug and an annular wall that concentrically encloses the plug while forming an annular gap. The male connector also has an internal thread facing toward the plug. The female connector has a socket complementary to the plug and an external thread complementary to the internal thread. The female connector is inserted into the annular gap of the male connector in a connected state. An inactive adhesive arrangement is provided in the annular gap and assigned an activation system, in such a way that activation of the adhesive arrangement takes place as a result of insertion of the female connector into the annular gap of the male connector.

Abstract: A cap configured to engage at least a first connector and a second connector of different types includes a housing having a first end, an open second end, a sidewall extending between the first end and the second end, and a plurality of interfering protrusions extending inwardly from an inner surface of the sidewall configured to provide an interference engagement with the first connector or the second connector. The cap also includes an absorbent support positioned in the housing configured to contact portions of the first connector or the second connector, when the first connector or the second connecter is inserted into the housing and a seal mounted to a portion of the absorbent support configured to cover an opening of the first connector or the second connector when the first connector or the second connector is inserted into the housing.

Abstract: A sterile interface system for placement between a syringe and an IV port to provide a closed system for drawing up and injecting liquid drugs, comprises an IV cannula interface for connection to an IV delivery tube, a syringe interface for a connection to a drug delivery syringe and a shrouded interface positioned between the IV cannula interface and the syringe interface. The sterile interface system includes several puncturable silicone structures which are pierced by a cannula mounted longitudinally within the IV cannula interface to provide a sterile flow path.

Abstract: Described herein are systems for an aseptic connector, including a reusable aseptic connector. A connector system is provided for establishing the aseptic fluid connection. The connector system includes a first connector, a second connector and an airlock. Also provided is an air lock and a connector, as well as methods of use thereof.

Abstract: A medical device, an elastically deformable functional part for a medical device, and a method for sterilizing and/or for establishing sterilization resistance of a medical device or an elastically deformable functional part. The elastically deformable functional part has an openable slit arrangement. The slit arrangement widens or opens upon elastic deformation of the elastically deformable functional part and recloses upon cessation of the elastic deformation. The slit arrangement has slit wall faces with a separating agent. The separating agent can be a solid.

Abstract: A needleless connector may include a housing having an inlet port, an outlet port, and an inner surface defining an internal cavity extending between the inlet and outlet ports, and a compressible valve reciprocally disposed within the internal cavity. In a closed state, a top section of a head portion of the compressible valve may have a planar shape configured to contact and seal against the inner surface of the housing. In an open state, where the compressible valve is subject to an axial force, the top section of the head portion may be lodged between two pinch points between opposing walls of an inwardly angled portion of the internal surface. Additionally, in the open state, the top section of the head portion may have a non-planar shape defining a fluid path extending at least partially between opposing walls on an outwardly angled portion of the internal surface.

Abstract: A pinch clamp device may include a first arm, which may include a first end, a second end, a first clamping surface, a first extension, and a set of first ledges proximate the first extension. The pinch clamp device may include a second arm, which may include a first end, a second end, a second clamping surface, a second extension, and a set of second ledges proximate the second extension and configured to align with the first clamping surface when the pinch clamp device is in a closed position. The set of first ledges may be configured to align with the second clamping surface when the pinch clamp device is in the closed position. The pinch clamp may include a hinge interconnecting the second end of the first arm and the second end of the second arm.

Abstract: A blood pump (100) and a driving device (10) thereof.

Abstract: Catheter blood pumps that include an expandable pump portion. The pump portions include a collapsible blood conduit that defines a blood lumen. The collapsible blood conduits include a collapsible scaffold adapted to provide radial support to the blood conduit. The pump portion also includes one or more impellers. The collapsible scaffold may include portions of differing radial stiffness based on location of the one or more impellers therein.

Abstract: A heart assist device comprising a rotary pump housing having a cylindrical bore, a pumping chamber and a motor stator including an electrically conductive coil located within the housing and surrounding a portion of the cylindrical bore. A rotor has a cylindrical shaft with an impeller and one or more rotor magnets located within the shaft that are responsive to the motor stator to drive actuation of the rotor. The housing bore is closely fitted to the outer surface of the shaft forming a hydrodynamic journal bearing with an annular clearance defining a leakage flow path. One or more of radial or axial thrust bearings may provide rotation stability to the rotor and flow within the leakage flow path. The relative orientation of positions of the inflow, outflow, and leakage flow paths may be varied within the pump, such as to accommodate different intended methods for implantation and/or use.

Abstract: The invention relates to a fluid pump device, in particular for the medical application, with a compressible pump housing and rotor, as well as with an actuation means which runs in the sleeve and on whose end the fluid pump is arranged. In order to utilize all possibilities of a space-saving arrangement of the respective pump housing of the rotor, which is compressible per se, and as the case may be, a bearing arrangement, the mentioned elements are displaceable to one another in the axial direction compared to an operation position. In particular these elements may be end-configured by way of an axial movement of the drive shaft after the assembly.

Abstract: A blood pump (100) and a driving device thereof. The driving device (10) comprising a driving shell (11), a rotor (12) and a stator mechanism (13); the rotor (12) comprises a rotating shaft (121) and a first magnet (122), one end of the rotating shaft (121) is accommodated in the driving shell (11), and the first magnet (122) is fixedly connected with the rotating shaft (121); the stator mechanism is accommodated in the driving shell (11), the stator mechanism (13) comprises a driving stator (131), the driving stator (131) and the rotating shaft (121) are provided at intervals along the axis of the rotating shaft (121), and the driving stator (131) can generate a rotating magnetic field interacting with the first magnet (122), so that the first magnet (122) can drive the rotating shaft (121) to rotate.

Abstract: The invention relates to a blood pump. The blood pump comprises a flexible drive shaft guided in a catheter, a conveying element connected to the drive shaft in a distal region of the drive shaft, and a motor, wherein the motor has a stator and a rotor mounted such that it can move in the stator. The stator comprises a winding and the rotor comprises a rotor magnet. In addition, the drive shaft is connected to the rotor at a proximal end of the drive shaft. The stator and the rotor are nondetachably connected to one another, and form a gap with a ring-shaped cross-section, which is delimited by the rotor and the stator.

Abstract: Methods and apparatus for an auxiliary monitor for a patient monitoring system including a first patient monitoring device and a second patient monitoring device are described. The auxiliary monitor comprises a communication interface configured to receive first data from the first patient monitoring device and second data from the second patient monitoring device, and at least one computer processor. The at least one computer processor is programmed to display in a first portion of a user interface, an indication of the first data, and display in a second portion of the user interface, an indication of the second data.

Abstract: A patient-worn arrhythmia monitoring and treatment device includes an anterior adhesively coupled pad, a posterior adhesively coupled pad, and a wearable support integrated with the anterior and posterior adhesively coupled pads. The wearable support is configured to bear at least a portion of the weight of at least one of the anterior adhesively coupled pad or the posterior adhesively coupled pad. The device also includes a pair of therapy electrodes configured to deliver one or more therapeutic pulses, a plurality of ECG sensing electrodes, a first housing, a second housing, an ECG acquisition and conditioning circuit, a therapy delivery circuit, and a processor. The processor is configured to analyze the at least one ECG signal of the patient, detect one or more treatable arrhythmias, and cause the therapy delivery circuit to deliver up to five therapeutic pulses to the patient.

Abstract: A transducer array for use in tumor-treating fields (TTFields) therapy is particularly suited for use in treating abdominal or thoracic cancers. The transducer array has features that increase its flexibility and adhesion to the patient's skin, including a branching configuration and a correspondingly branching top covering adhesive-backed layer. Additionally, a skin-level adhesive layer is provided beneath the flex circuit to which the electrode elements are attached, to help ensure thorough, lasting adhesion of the transducer array to the patient's skin over the course of treatment.

Abstract: A system for stimulating body tissue may include a user interface and a control unit. The control unit may include a processor and non-transitory computer readable medium. The non-transitory computer readable medium may store instructions that, when executed by the processor, causes the processor to identify an electrode combination and determine a threshold charge for use in stimulating the body tissue. The processors identifications and determinations may be based at least partially on input received via the user interface.

Abstract: A method of forming a stimulation lead includes forming an implantable lead body, including helically winding at least one cable about a mandrel to form a coiled cable assembly in a first, restrained state. Helically winding the at least one cable includes applying a tensile force to the at least one cable as the at least one cable is wound about the mandrel. Forming the lead body also includes releasing the tensile force from the at least one cable to allow the coiled cable assembly to release stored mechanical energy and transition from the restrained state to a second, relaxed state in which the coiled cable assembly is substantially free of stored mechanical energy. The method further includes subjecting the lead body to a reflow process by applying heat to the lead body, where the tensile force is released prior to the lead body being subjected to the reflow process.

Abstract: A medical device, including an implantable portion of the medical device, the implantable portion including at least one electrode, wherein the implantable portion is configured to, while implanted in a human, obtain data indicative of wear of the at least one electrode. In an exemplary embodiment, the medical device is a cochlear implant.

Abstract: A device for treating a user's skin using plasma is provided. The device comprises a plasma generation assembly and a power supply. The plasma generation assembly comprises a discharge electrode including a first surface; a first dielectric material layer provided on the first surface of the discharge electrode and the first surface, a ground electrode surrounding the discharge electrode, and an insulation member spacing around the discharge electrode from the ground electrode. The power supply configured to apply power to the plasma generation assembly so that plasma is generated from the first surface of the discharge electrode to the ground electrode and between the first dielectric material layer and the user's skin.

Abstract: A method for treatment of erectile dysfunction is described using RF energy with multiple electrodes applied to the treated tissue.

Abstract: A system and method for visualizing a position of a needle inside a patient's body for use in providing regional anesthesia and a system and method for providing electro anesthesia during surgery, post surgery and during rehabilitation. The method and system use EMG/AMG information regarding activity of a muscle associated with a target nerve to provide a visualization of a position of a needle or other device relative to the target nerve and to determine efficacy of the electro anesthesia. EMG/AMG information and feedback information such as EEG information may be used to provide automatic adjustment of a waveform provided for electro anesthesia to maintain a suitable pain level.

Abstract: The electrical stimulation device includes: positive and negative electrodes to be attached to epidermis of agonist-antagonist muscles acting on a target joint; a display unit; an EMG rehabilitation unit that detects an electromyogram of the agonist-antagonist muscles via the electrodes and outputs variation information corresponding to the detected electromyogram to the display unit; a FES rehabilitation unit that instructs motion of the agonist-antagonist muscles via the display unit and outputs a stimulation current signal corresponding to the instructed motion of the agonist-antagonist muscles to the electrodes; a model (inverse model) storage unit that stores models obtained beforehand and relating to target muscle characteristics, the models including: a model for converting the detected electromyogram into the variation information; and a model for converting information on the motion of the agonist-antagonist muscles into the stimulation current signal; and a rehabilitation processing unit that select

Abstract: Disclosed are techniques for treating pain and/or inflammation. In an aspect, a method of treating pain and/or inflammation includes determining, based on information associated with a treatment recipient, that a flare-up of pain and/or inflammation (“flare-up”) is in progress or that a likelihood of a flare-up exceeds a threshold level, and providing, to the treatment recipient, treatment to avoid or mitigate the flare-up. In some aspects, the treatment recipient can select a preferred treatment. In some aspects, the treatment is provided to the treatment recipient via a portable, wearable unit that includes hardware for providing multiple therapies, such heat, cold, infrared light, transcutaneous electrical nerve stimulation, and low frequency pulsed electromagnetic field, singly, in sequence, and/or in combination. In some aspects, a software application detects the flare-up or potential flare-up via a machine learning model and provides treatment via the portable, wearable unit.

Abstract: Described herein are apparatuses (e.g., systems and devices) and methods of delivering nanosecond pulsed electrical fields (nsPEF). In particular, these apparatuses and methods may provide enhanced safety and robust operation over even very short (e.g., nanosecond and sub-nanosecond pulses) and high voltage pulsing; these benefits may be accomplished by multi-functional isolation of various subsystems and components of the apparatus, even including the low-voltage, control and command portions of the apparatus with extremely low capacitance, high voltage isolation.

Abstract: A method of treating an inflammation in a patient is provided. The method includes stimulating, in a patient suffering from inflammation, the patient's vagus nerve with an electrical signal to achieve a therapeutic effect for treating the inflammation. The signal current is 0.4 mA, the pulse width is 250 ?s, the signal frequency is 20 Hz, and the signal on-time is twenty minutes. The method also includes re-stimulating the patient's vagus nerve a second time within 24 hours of the first stimulation. The electrical signal for a first stimulation and the second stimulation are the same.

Abstract: Systems and methods for treating bladder and/or bowel dysfunction of a patient includes a stimulation element implanted to stimulate one or more target sites, and a sensor to sense sensing at least one parameter of the patient indicative of a potential bladder or bowel dysfunction event. In some examples, stimulation energy is applied to an anatomical structure of the patient as a function of the sensed parameter, for example to address the potential bladder or bowel dysfunction event.

Abstract: A method for assessment, optimization and logging of the effects of a therapy for a medical condition, including (a) receiving into a signal processor input signals indicative of the subject's brain activity; (b) characterizing the spatio-temporal behavior of the brain activity using the signals; (c) delivering a therapy to a target tissue of the subject; (d) characterizing the spatio-temporal effect of the therapy on the brain activity; (e) in response to the characterizing, optimizing at least one parameter of the therapy if the brain activity has not been satisfactorily modified and/or has been adversely modified by the therapy; (f) characterizing the spatio-temporal effect of the at least one optimized parameter; and (g) logging to memory the at least one optimized parameter. A computer readable program storage unit encoded with instructions that, when executed by a computer, performs the method.

Abstract: An example of a system for delivering neurostimulation from a stimulation device may include a programming control circuit and a programming control circuit. The programming control circuit may be configured to generate information for programming the stimulation device to deliver the neurostimulation according to a pattern of neurostimulation pulses. The stimulation programming circuit may be configured to: receive goal option(s) selected from a plurality of goal options each including at least one goal for deep brain stimulation; select programmability option(s) associated with the received goal option(s) from a plurality of programmability options each allowing one or more aspects of the pattern of neurostimulation pulses and/or its delivery to be programmable; receive programming information required by the selected programmability option(s); and determine the pattern of neurostimulation pulses for the selected goal option(s) using the received programming information.

Abstract: A method, system and device for implanting an electrode assembly of an implantable medical device in a patient's heart. Positioning one or more radiopaque markers in a coronary sinus of the patient's heart. Positioning, by using the one or more positioned radiopaque markers as a fluoroscopic visual reference, a distal tip of a delivery catheter within a right atrium of the patient's heart so that a distal opening of a lumen of the catheter is against a septal wall of the heart at a location between the ostium of the coronary sinus and the A-V nodal area of the right atrium, and so that the tip of the catheter is generally directed toward a left ventricle of the patient's heart. Advancing the electrode assembly through the lumen of the catheter and into the septal wall.

Abstract: A medical device system and method estimate a time from a first voltage of a power source of a medical device to a second voltage of the power source. The medical device includes a sensor coupled to the power source for generating a physiological signal. The medical device system determines a current drain from the power source required for generating the physiological signal and/or processing the physiological signal for detecting events from the physiological signal. A processor of the medical device system is configured to estimate the time from the first voltage of the power source until the second voltage based on at least the determined current drain.

Abstract: Techniques for pairing an external device such as a clinician programmer (CP) to an implantable medical device (IMD) are disclosed, which involve use of a remote controller (RC) paired to the IMD. The RC is placed into a CP pairing mode, which acts differently depending on the type of IMD paired to the RC. If the IMD is RF based, the CP pairing mode places the IMD in a pairing mode, thus allowing the CP to connect directly with the IMD via a RF telemetry protocol. If the IMD is magnetic-induction based, the CP pairing mode causes the RC to advertise its presence to the CP, allowing the CP to connect to the RC via the RF telemetry protocol. Because the RC is also paired with the IMD via a magnetic induction telemetry protocol, the RC acts as a passthrough device to allow communications between the CP and the IMD.

Abstract: An electric potential generation method that includes generating a magnetic field having an intensity based on an arbitrary first temporal pattern in a region including a target position inside an object, using a magnetic field formation unit that generates a magnetic field: generating one or more ultrasonic waves in which respective parameters of direction, frequency, amplitude, and phase are separately adjusted, by separately controlling one or more wave sources; generating a force having a desired direction, intensity, and shape in accordance with the first temporal pattern so as to move a prescribed region of the object at the target position based on the force, by irradiating the target position with the one or more ultrasonic waves; and generating an arbitrary electric potential based on the magnetic field in the prescribed region.

Abstract: The present invention is a magnet device for relieving aches and/or pain. One non-limiting embodiment is a magnet device for relieving aches and/or pain of a particular body area of a user wherein magnet device includes a plurality of magnets arranged end to end in close proximity to one another in a generally linear configuration, and a wire, a rod or an elongated extension for securing the magnets together in a generally linear configuration. Another non-limiting embodiment is a magnet device for relieving aches and/or pain of a particular body area of a user wherein magnet device includes a plurality of magnets arranged end to end in close proximity to one another, and a body brace or pad adapted for securing at least one linear configuration of the magnets to or inside the body brace or pad. This embodiment may also include a wire, a rod or an elongated extension.

Abstract: Combined methods for treating a patient using time-varying magnetic field are described. The treatment methods combine various approaches for aesthetic treatment. The methods are focused on enhancing a visual appearance of the patient.

Abstract: A skin treatment device, typically but not exclusively an IPL device, has a housing, a light source for discharging light energy pulses, a control system for controlling discharge of the light source and a housing output window in the housing for transmission of light energy pulses emitted by the light source to external of the housing onto a skin treatment area. One or more sensors are disposed in the housing adjacent to the output window to provide sensing zones. The control system is arranged to receive one or more sensor outputs and based on these outputs control operation of the device. A head is releasably engaged with the housing and has a shield portion and a head window portion where in an engaged configuration the shield portion partially shields the output window to reduce the skin treatment area and leave one or more of the sensing zones exposed.

Abstract: A system and method for treating a tissue is provided. The treatment causes a tightening or lifting of tissue. The method includes delivering a photochemical agent through a depth of the tissue to distribute the photochemical agent adjacent proteins within the tissue and irradiating the tissue with an electromagnetic irradiation at a wavelength that activates the photochemical agent, causing a protein response that brings fibers of the tissue closer together in order to one of reduce tissue laxity and tighten the tissue. A kit is provided to facilitate the method.

Abstract: An automated brachytherapy apparatus and method include robotics and/or image guided brachytherapy.

Abstract: A radiotherapy device may comprise a fixed support structure and an inner cover defining a bore. The inner cover may be movable with respect to the fixed support structure from a first position. In an example, the inner cover may be movable from the first position in two dimensions, in a plane of a circular cross section of the inner cover.

Abstract: Retinal disease is responsible for many instances of vision impairment. Often, individuals with vision impaired due to retinal disease continue to have functioning retinal neurons. Thus, systems, methods, and devices to stimulate retinal neurons may restore sight for vision-impaired individuals. Systems, methods, and devices provided herein direct ultrasound energy into retinal neurons and modulate phase and amplitude of ultrasound energy in time and space domains in order to variously stimulate various retinal neurons, generating neural responses consistent with visual reproduction of intended images.

Abstract: A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening/non-target tissues or structures.

Abstract: Disclosed are a high-intensity focused ultrasound (HIFU) device capable of the three-dimensional treatment, a control method thereof and a treatment method using the same, in which treatment spots are formed along a circular path by rotating ultrasound transducers during skin treatment, thereby enabling three-dimensional treatment.

Abstract: A cleanroom coverall includes a coverall suit and a ventilator positioned inside the coverall suit. The ventilator is fluidly connected to the ambient of the coverall, such that between the ambient of the coverall suit and the ventilator, a one-way valve is present which is situated upstream the ventilator and which one-way valve opens when the ventilator is active.

Abstract: Methods and devices with noninvasive means for providing moisture from breath to the eyes and nose, for relieving dry eye symptoms and relieving dry nose symptoms, and to hydrate the eyes, nose and facial skin are described. The device for relieving dry eye symptoms comprises a face covering over the nose, a breath deflector and a means that can attach the device to the face.