Abstract: The present application is directed to bispecific polypeptides comprising a first domain binding an antigen on an antigen presenting cell (ARC) and a second domain binding an antigen on an immune cell expressing a chimeric antigen receptor (CAR). Nucleic acids, vectors and host cells used in producing the polypeptide of the invention are also disclosed. Compositions comprising the bispecific polypeptides and methods of treating cancer and stimulating activation and expansion of immune cells in vivo and in vitro are also disclosed.

Abstract: The present disclosure provides pharmaceutical compositions comprising bispecific antibodies and antigen binding fragments thereof that bind to 4-1BB and OX40. Also provided are methods for treating disorders, such as cancer, using such compositions.

Abstract: Described herein are proteins comprising an Fc region or the like, such as monoclonal, bispecific and multispecific antibodies, wherein the Fc region has been modified to eliminate or strongly reduce Fc-mediated effector functions, while at the same time allow for good developability, for therapeutic purposes and where such effector functions are undesired.

Abstract: The disclosure is directed to treatment regimens for treating Multiple Sclerosis (MS).

Abstract: The invention concerns methods and means for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.

Abstract: Provided herein are dosing and combination therapies with a CD39 antibody, a PD-1 antibody, and FOLFOX or CAPDX in gastric cancer.

Abstract: Antibody molecules that specifically bind to C5aR1 are disclosed. The antibody molecules can be used to treat, prevent, and/or diagnose disorders, such as ANCA-vasculitis.

Abstract: Novel bispecific heterodimeric immunoglobulins that target both a component of the human CD47 antigen and human CD38 antigen are provided and in particular those comprising an anti-CD38 heavy chain variable region and a light chain variable region and an anti-CD47 heavy chain variable region and a light chain variable region. The present invention also relates to the use of this novel class of bispecific heterodimeric immunoglobulins to treat autoimmune and proliferative diseases and in particular cancers such as hematologic malignancies and solid tumors.

Abstract: A humanized antibody specifically recognizing human CA IX, and to therapeutic and diagnostic methods utilizing this antibody is disclosed. The methods relate in particular to treatment or diagnosis of cancers selected from squamous cell carcinoma, myeloma, small-cell lung cancer, non-small cell lung cancer, glioma, hodgkin's lymphoma, non-hodgkin's lymphoma, acute myeloid leukemia, multiple myeloma, gastrointestinal (tract) cancer, renal cancer, ovarian cancer, liver cancer, lymphoblastic leukemia, lymphocytic leukemia, colorectal cancer, endometrial cancer, kidney cancer, prostate cancer, thyroid cancer, melanoma, chondrosarcoma, neuroblastoma, pancreatic cancer, glioblastoma multiforme, cervical cancer, brain cancer, stomach cancer, bladder cancer, hepatoma, breast cancer, colon carcinoma, mesothelioma, and head and neck cancer.

Abstract: The invention provides anti-KLK7 antibodies, anti-KLK5 antibodies, anti-KLK5/KLK7 multispecific antibodies, and methods of using the same.

Abstract: Provided herein antibodies, activatable antibodies (AAs), bispecific antibodies, and bispecific activatable antibodies (BAAs). Also provided herein are methods of making and methods of use of these antibodies, AAs, bispecific antibodies, and BAAs.

Abstract: Provided herein, in one aspect, are antibodies that immunospecifically bind to a human KIT antigen comprising the fourth and/or fifth extracellular Ig-like domains (that is, D4 and/or D5 domains), polynucleotides comprising nucleotide sequences encoding such antibodies, and expression vectors and host cells for producing such antibodies. The antibodies can inhibit KIT activity, such as ligand-induced receptor phosphorylation. Also provided herein are kits and pharmaceutical compositions comprising antibodies that specifically bind to a KIT antigen, as well as methods of treating or managing a KIT-associated disorder or disease and methods of diagnosing a KIT-associated disorder or disease using the antibodies described herein.

Abstract: This disclosure is based, at least in part, on an unexpected discovery that the novel nanobodies and variants thereof are able to specifically bind afucosylated or sialylated IgG Fc glycoforms. Glycosylation of the IgG Fc domain is a major determinant of the strength and specificity of antibody effector functions, modulating the binding interactions of the Fc with the diverse family of Fc? receptors. These Fc glycan modifications, such as removal of the core fucose residue, are newfound clinical markers for predicting severity of diseases, such as diseases caused by dengue virus (DENV) or SARS-CoV-2. However, it remains challenging to accurately distinguish specific IgG glycoforms without costly and time-intensive methods. The novel glycol-specific nanobodies and variants thereof, as disclosed herein, can be used as rapid clinical diagnostics or prognostics to risk stratify patients with viral and inflammatory diseases.

Abstract: The present invention provides a multivalent immunoglobulin or part thereof binding specifically to at least two cell surface molecules of a single cell with at least one modification in at least one structural loop region of the immunoglobulin determining binding to an epitope of the cell surface molecules wherein the unmodified immunoglobulin does not significantly bind to the epitope, its use and methods for producing it.

Abstract: The present invention relates to new aqueous curable binder compositions comprising a carbohydrate compound, a first cross linker and a second cross linker different from the first capable of undergoing radical polymerization and possibly a free radical initiator.

Abstract: Disclosed herein are detergent compositions that comprise at least one (i) glucan derivative and/or (ii) oxidized polysaccharide derivative. A glucan derivative of (i) can be substituted with at least one organic group that comprises a carboxylic acid group or a sulfonate group, and the degree of substitution (DoS) of the glucan derivative with the organic group can be about 0.1 to about 3.0. An oxidized polysaccharide derivative of (ii) can be produced by contacting a polysaccharide derivative under aqueous conditions with at least one agent that is capable of oxidizing the polysaccharide derivative. The polysaccharide derivative for oxidation has a degree of substitution (DoS) up to about 3.0 with at least one organic group. Further disclosed are various applications and products employing detergent compositions.

Abstract: The present invention relates to chitin with a differential purity of more than 97.75% and to a process for producing chitin and/or chitosan by the enzymatic and chemical pathway.

Abstract: A two-component hydrogel matrix system is described, which has a variety of benefits for cell and tissue culture; including without limitation hydrogels that allow for cells to more easily migrate into/through, proliferate, spread, and deposit matrix within the gel; stable hydrogels that allow for higher retention that can be held together for prolonged periods of time, etc. The components comprise: (1) chemically modified hyaluronic acid (HA) comprising an aldehyde or benzaldehyde containing side group, and a bicyclononyne containing side group, and (2) chemically modified elastin-like protein (ELP) comprising a hydrazine containing side group and an azide containing side group.

Abstract: A substrate processing apparatus includes a processing container; a stage on which a substrate is placed, the stage being provided in the processing container; a gas supply provided at a position facing the stage and configured to supply a first processing gas containing a first monomer and a second processing gas containing a second monomer into the processing container to form a film of a polymer on the substrate; and a driver configured to move the stage so as to change a distance between the gas supply and the stage. The gas supply is configured to supply the first processing gas and the second processing gas into a space between the gas supply and the stage from an outside of a region on the stage in which the substrate is placed, when viewed in a direction from the gas supply toward the stage.

Abstract: Fluorided silica-coated alumina activator-supports have a bulk density from 0.15 to 0.37 g/mL, a total pore volume from 0.85 to 2 mL/g, a BET surface area from 200 to 500 m2/g, an average pore diameter from 10 to 25 nm, and from 80 to 99% of pore volume in pores with diameters of greater than 6 nm. Methods of making the fluorided silica-coated alumina activator-supports and using the fluorided silica-coated aluminas in catalyst compositions and olefin polymerization processes also are described. Representative ethylene-based polymers produced using the compositions and processes have a melt index of 0.1 to 10 g/10 min and a density of 0.91 to 0.96 g/cm3, and contain from 70 to 270 ppm solid oxide and from 2 to 18 ppm fluorine.

Abstract: Embodiments are directed towards a use of a supported biphenylphenol polymerization catalyst to make a polymer via a slurry-phase polymerization process, where the supported biphenylphenol polymerization catalyst is made from a biphenylphenol polymerization precatalyst of Formula I.

Abstract: A propylene-ethylene copolymer includes propylene as a primary monomer, an ethylene content (ET) of 3.0% to 5% by weight, a melt flow rate of from 20 to 45 g/10 min, a xylene soluble fraction (XS) of from 2.0% to 7.0% by weight, and an XS/ET ratio of less than or equal to 1.51.

Abstract: The present disclosure relates to a method of preparing a polymer, which includes: adding an alkyl-substituted aromatic vinyl-based monomer and a vinyl cyanide-based monomer to a reactor and initiating polymerization; and performing polymerization while continuously adding an alkyl-substituted aromatic vinyl-based monomer and a multifunctional initiator to the reactor, wherein the continuous addition of the alkyl-substituted aromatic vinyl-based monomer and the multifunctional initiator is initiated when a polymerization conversion rate is 10 to 30%, and the continuous addition of the alkyl-substituted aromatic vinyl-based monomer and the multifunctional initiator is terminated when a polymerization conversion rate is 70 to 80%.

Abstract: A method for producing a polytetrafluoroethylene powder, which includes subjecting tetrafluoroethylene to suspension polymerization in an aqueous medium to prepare a suspension-polymerized particle of non melt-processible polytetrafluoroethylene, drying the suspension-polymerized particle to prepare a dry particle, subjecting the dry particle to fluorine radical treatment to prepare a fluorine radical-treated particle, and crushing the fluorine radical-treated particle to produce a polytetrafluoroethylene powder. Also disclosed is a polytetrafluoroethylene formed article obtained by forming the polytetrafluoroethylene powder, as well as a polytetrafluoroethylene compression-molded article obtained by compression molding the polytetrafluoroethylene powder.

Abstract: Provided herein are curable fluoroelastomer compounds comprising a fluoroelastomer and a curing agent. The curing agent comprises an amidocarboxylic acid and an amidine-containing molecule or a salt that is the product of a reaction between an amidocarboxylic acid and an amidine-containing molecule. Further provided are articles comprising the curable fluoroelastomer compounds or a product of curing the fluoroelastomer compounds; processes for curing the compounds; and processes for making the articles.

Abstract: The present invention pertains to liquid droplets including a polymer according to Formula (I) and to their use in an aqueous medium for the uptake of compounds from outside the droplets into the droplets for separation, storage and/or reaction of compounds inside the droplets, as well as associated methods of production of the polymer.

Abstract: In some examples, novel photochemically-reversible hydrogels and nanogel particles are described comprising copolymer chains including at least one reactive alkene or reactive 1,4-diene end group capable of [2+2] or [2+2+2+2] photodimerization, respectively, at wavelengths >270 nm. In various examples, the photochemically-reversible hydrogels comprise copolymer chains including at least one —N3, —C?CH or —CO2H end group for dual functionality and/or pH responsiveness. For nucleic acid sequencing, amplification primers are grafted to photochemically-reversible hydrogels or nanogel particles reversibly bound to surfaces within a flow cell. After sequencing is complete, the photochemically-reversible hydrogel or nanogel particles is/are removable from the flow cell surfaces by irradiation, enabling the flow cell to be reusable.

Abstract: A novel synthetic functionalized backbone polymer is provided which is a polyanionic side-chain functionalized backbone polymer comprising a hydrophilic backbone polymer functionalized with an activated alkene or epoxy group. The functionalized backbone polymer may be combined with a free or protected thiol-containing compound to form a crosslinked hydrogel having biomedical application, and may additionally be combined with a hydrogel matrix to yield a hydrogel system useful for in vivo delivery of cells and other therapeutic agents.

Abstract: Disclosed are a photo-curable resin composition, and a molded article manufactured therefrom, the photo-curable resin composition comprising: 60-80 parts by weight of a (meth)acrylated urethane-based polymer; 10-30 parts by weight of a (meth)acrylate-based compound including at least one C3-C20 cyclic alkyl group; and 1-3 parts by weight of a photopolymerization initiator.

Abstract: A weak base anion resin has alkylamine segments covalently bound to cross-linking segments, the alkylamine segments being selected from a group consisting of: vinylamine, N-methylvinylamine, N,N-dimethylvinylamine, N-methyl-N-ethylvinylamine, and N,N-diethylvinylamine, and the weak base anion resin including ions adsorbed to the alkylamine segments. A method for ion exchange includes providing a weak base anion resin, contacting the weak base anion resin with a solution containing ions to one of capture or adsorb ions from solution to the weak base anion resin, and regenerating the weak base anion resin. A method to capture and release an acid gas includes providing a weak base anion resin, contacting the weak base anion resin with a gas including an acid gas to one of capture or adsorb the acid gas from the gas to the weak base anion resin, and regenerating the weak base anion resin to release the acid gas.

Abstract: The resin composition incudes a polymer compound represented by the formula (1), where in formula (1), R1 and R2 each independently represent a hydrogen atom or a methyl group, and m and n represent the average numbers of repeating units, and are each independently in the range between 1 and 2000 inclusive; a compound that can radically polymerize with the polymer compound; and a radical initiator. The compound that can radically polymerize with the polymer compound is at least one selected from the group consisting of phenylmaleimide compounds, acenaphthylene compounds, modified polyphenylene ether resins having an unsaturated double bond at an end, and aryl isocyanurate compounds.

Abstract: Provided is an epoxy resin which can improve the durability when used with a rubber material, and a method of producing an epoxy resin. In the present disclosure, a diene-based polymer is grafted onto a main chain of an epoxy resin.

Abstract: The present application is directed to methods for preparation of carbon materials. The carbon materials comprise enhanced electrochemical properties and find utility in any number of electrical devices, for example, as electrode material in ultracapacitors or batteries.

Abstract: The present invention relates to catalyst compositions including (i) urethane, thiourethane and urea adducts of amine catalysts and (ii) ?-diols with 3 to 12 carbon atoms as well their use for the crosslinking of aliphatically, cycloaliphatically, araliphatically or aromatically bonded isocyanate groups with one another.

Abstract: The present invention provides a sulfur containing polyisocyanate polyaddition (PIPA) polyether polyol dispersion at a readily processible viscosity for use in making flexible polyurethane foams having inherent flame retardant properties that comprises a polyether polyol carrier and from 10 to 25 wt. %, based on the total weight of the dispersion, of particles of a sulfur containing polyisocyanate polyaddition (PIPA) polyether polyol having a particle size diameter (PSD), as determined by laser light scattering, of 90%, by volume, of the particles in the dispersion having a maximum PSD of from 0.2 to 4.5 am and that, further, contain two or more aromatic carbamate groups. The dispersion may further comprise water or a blowing agent, g) one or more catalysts; and f) one or more polyisocyanates in a foam forming mixture.

Abstract: The purposes of the present invention are: to provide an epoxy resin composition having excellent impregnation into reinforcing fibers, excellent shapability under low-temperature conditions after thickening, and excellent heat resistance after curing; to provide a molding material for a fiber-reinforced composite material, said molding material having excellent shapability during handling and excellent fluidity during press molding; and to provide a fiber-reinforced composite material having excellent heat resistance and bending strength. To achieve the abovementioned purposes, the present invention provides an epoxy resin composition containing all of the following components (A)-(D), wherein: the content of the component (A), in terms of 100 mass % of the total mass of the epoxy resin composition, is 30-95 mass %; and the ratio Wc/Wd of the content We of the component (C) to the content Wd of the component (D) is 0.01-10.

Abstract: The present disclosure generally relates to a one component epoxy resin-based composition including an epoxy resin, a reactive diluent, a cyanoacetamide derived from a cycloaliphatic-type diamine and a polyoxyalkylene amine, a protected base in the form of an adduct or salt which can release a base upon heating at a temperature of greater than about 50° C. and a polyacid and its use in trickle impregnation processes.

Abstract: This disclosure relates to polymeric membranes that incorporate a hydroxyl-functionalized CARDO moiety that can be used in sour natural gas separation and purification applications.

Abstract: Methods for regioselective ring-opening polymerization of unsymmetrical cyclic diester monomers, polymers, which may be made by the methods, and uses of same. Monomers may include cyclic hydroxy-acid dimers, such as, for example, 3-methyl glycolide and the like. Polymerization initiators may include chiral metal alkoxide initiators, such as, for example, (SalBinam)Al-01Pr initiators and the like. Polymers may include polyesters, such as, for example, poly(lactic-co-glycolic acid) (PLGA) and the like, with 90% or greater regioselectivity for alternating ester units (e.g., glycolic unit-lactic unit (G—L) linkages). Polymers may be utilized for substained or targeted drug delivery vehicles, scaffolding for tissue engineering, bioabsorbable sutures, or the like.

Abstract: A polycarbonate resin including a unit of Chemical Formula 1, a method for preparing the same, a polycarbonate resin composition including the same, and a molded article including the polycarbonate resin composition are described: wherein all the variables are described herein.

Abstract: Provided is a water-repellent member in which a silica layer having a specific thickness and mainly composed of silica nanoparticles is provided on the outer surfaces of various substrates, and then a water- and oil-repellent layer having a specific thickness and containing a cured product of a fluorine-containing organosilicon compound as a main component is provided on the outer surface of the silica layer. The water-repellent member is obtained by a method comprising: a step for wet coating a dispersion containing silica nanoparticles and a solvent onto the outer surface of a substrate; a step for drying and removing the solvent from the dispersion; a step for wet coating a solution containing a fluorine-containing organosilicon compound and a solvent onto the outer surface of a silica layer formed by drying and removing the solvent; and a step for drying and removing the solvent from the solution to cure the fluorine-containing organosilicon compound.

Abstract: The present disclosure provides a semi-aromatic copolyamide, its preparation method, compositions, and a molded product thereof. The semi-aromatic copolyamide is formed from raw materials including diacid monomers and diamine monomers. The diacid monomers include aromatic diacid or derivatives of the aromatic diacid and aliphatic diacid. The diamine monomers include decamethylene diamine and pentamethylene diamine. The molar ratio of the decamethylene diamine to the pentamethylene diamine is in a range of 1:1 to 30:1.

Abstract: The present invention relates to novel polyimide polymers containing certain fluorinated diamine moieties, said polyimide polymers being characterized by excellent dielectric performances. The present invention also relates to the use of said polyimide-based polymers in polymer compositions in microelectronics applications.

Abstract: Provided are: a thermosetting resin composition from which a molded body exhibiting little change in optical characteristics when exposed to high temperatures can be obtained, and which can be applied to various packaging processes; an organosilicon compound from which the composition can be achieved; and a molded body and an optical semiconductor device which are obtained using such a thermosetting resin composition. The thermosetting resin composition includes: a compound that is selected from among organosilicon compounds (A) represented by Formula (1-1) or Formula (1-2); an organosilicon compound (B) that has a plurality of crosslinkable groups in its molecule and is other than the organosilicon compounds (A); and a hydrosilylation catalyst (C), in which the organosilicon compound (B) contains a compound that is crosslinkable with the organosilicon compounds (A).

Abstract: Provided is an organopolysiloxane compound serving as a raw material of an organopolysiloxane pressure-sensitive adhesive which has necessary and sufficient pressure-sensitive adhesive strength in a step such as temporary fixing or the like and can be easily peeled off from a substrate in a subsequent step; an organopolysiloxane pressure-sensitive adhesive composition containing the same; and a method for using the same. A chain co-modified organopolysiloxane containing a specific functional group having a (meth)acryl group (RA) and a functional group having an alcoholic hydroxyl group (ROH), wherein the amount of RA is in the range of 0.10 to 10.0 mol % with regard to all silicon atom-bonded functional groups in the molecule, and the average amount of ROH is in a range of 0.1 to 1.0 moles per mole of RA.

Abstract: Disclosed are liquid vinyl functionalized cage-type polyhedral oligomeric silsesquioxane modified by low-molecular-weight polysiloxane and a preparation method thereof. Under the catalytic action of tris(pentafluorophenyl)borane, cage-type octakis (dimethylsiloxy)-T8-silsesquioxane and hetero telechelic polydimethylsiloxane undergo a Piers-Rubinsztajn reaction, to obtain liquid Vi-POSS. Side chains of the liquid vinyl functionalized POSS in the present disclosure are Si—O—Si chain links, have better heat stability than that of common long-carbon-chain side chains, and contain vinyl functional groups capable of participating in chemical reactions, which not only have good mechanical enhancement and heat resistance properties, but also have chemical reactivity.

Abstract: The disclosure is directed at a hydrophilic silicone material with tunable viscoelastic features for forming a three-dimensional object that includes a hydrophilic polymer matrix; at least one cross-linking material; and at least one photoinitiator.

Abstract: Disclosed herein is a polymeric article comprises an elastomeric layer comprising cured synthetic polyisoprene particles that comprise a rare earth catalysed polyisoprene. The polyisoprene particles may comprise sulfur crosslinks and/or may be pre- vulcanized. Also disclosed herein are methods for producing polymeric articles comprising an elastomeric layer comprising cured synthetic polyisoprene particles that comprise a rare earth catalysed polyisoprene.

Abstract: To provide a resin composition, from which a molded body excellent in mechanical properties and having high elasticity, can be obtained, and the molded body obtained from such a resin composition. A resin composition comprising a melt-moldable fluororesin and inorganic fibers, wherein the ratio of the fluororesin to the sum of the fluororesin and the inorganic fibers is from 60 to 95 mass %, the inorganic fibers are inorganic fibers, of which at least a portion of the surface is treated with a sizing agent, and the mass loss ratio after heating the inorganic fibers at 400° C. for 60 minutes, is at most 3%; a method for producing the resin composition; and a molded body formed from the resin composition.

Abstract: The present invention relates to hard optically transparent films suitable as protective films for displays, in particular flexible OLED displays.