Abstract: A device implantable into the eye that includes an elongate duct portion defining two lumens that extend parallel to one another from a distal end to a neck spaced longitudinally from the distal end, a second portion including two tubular segments that extend or flare outwardly from the neck opposite one another with at least one additional tubular segment that extends between the two tubular segments such that the tubular segments of the second portion form a tubular loop that surrounds an interior area. The tubular segments of the second portion that form the tubular loop define a common lumen with a plurality of outlets that are in fluid communication with the two lumens of the duct portion to permit fluid to flow through the device.

Abstract: A treatment device for the surgical correction of hyperopia in the eye comprising a laser device controlled by a control device. The laser device separating corneal tissue by applying laser radiation. The control device controls the laser device for emitting the laser radiation into the cornea such that a lenticule-shaped volume is isolated. Removal thereof effects the desired correction. The control device predefines the volume such that a posterior surface and an anterior surface are connected via an edge surface that has a width in projection along the visual axis that is wider than the one which a straight line in the same projection, that is perpendicular at the edge of the posterior or the anterior surface would have relative to the associated surface and connects the anterior surface to the posterior surface or to the perceived extension thereof.

Abstract: In certain embodiments, a system for sensing occlusions in an optical system includes a first laser source configured to generate optical signals and a set of optical elements arranged to receive the optical signals from the first laser source and to direct the optical signals along a beam path. The system also includes a detector arranged to receive reflections of the optical signals traveling along at least a portion of the beam path and a control system communicably coupled to the detector. The control system is configured to detect, based on signals generated by the detector, reflection signals associated with the reflections of the optical signals, and disable a second laser source based on detection of the reflection signals.

Abstract: Devices and methods of laser surgery of an eye, especially for refractive surgery, preferably for keratoplasty. The invention includes a planning and control unit, a system for laser surgery of an eye and a planning and control method wherein a device coordinate system of the first laser device and a device coordinate system of the characterization device are coupled using registration and measurement data or model data of the lamella can be unambiguously registered to the device coordinate systems, further by a defined edge geometry of the lamella, an ametropia correction during the generation of the lamella and by taking into account the hydration condition of the lamella, as well as methods for surgery.

Abstract: A medical station includes a movable cart and a cassette system. The cassette system including a frame, a plurality of lockable drawers slidably mounted to the frame, and a graspable handle configured for movement between a closed position where the handle is not accessible or graspable by a user and a released position.

Abstract: A patient-positioning system, computer-control and data-integration system, and surgical componentry are provided. The patient-positioning system can be used to manipulate the patient prior to, during, and after surgery to globally or regionally articulate the patient's body to facilitate stabilization of the patient's spine. And the computer-control and data-integration system can be used to facilitate operation of the patient-positioning system and enabling technologies use to perform surgery. Furthermore, the surgical componentry can be used to locally articulate the patient's body and/or the stabilize patient's spine. Surgical methods of using the patient-positioning system, the computer-control and data-integration system, and the surgical componentry for improving patient health outcomes are also provided.

Abstract: A patient-positioning system, computer-control and data-integration system, and surgical componentry are provided. The patient-positioning system can be used to manipulate the patient prior to, during, and after surgery to globally or regionally articulate the patient's body to facilitate stabilization of the patient's spine. And the computer-control and data-integration system can be used to facilitate operation of the patient-positioning system and enabling technologies use to perform surgery. Furthermore, the surgical componentry can be used to locally articulate the patient's body and/or the stabilize patient's spine. Surgical methods of using the patient-positioning system, the computer-control and data-integration system, and the surgical componentry for improving patient health outcomes are also provided.

Abstract: A patient-positioning system, computer-control and data-integration system, and surgical componentry are provided. The patient-positioning system can be used to manipulate the patient prior to, during, and after surgery to globally or regionally articulate the patient's body to facilitate stabilization of the patient's spine. And the computer-control and data-integration system can be used to facilitate operation of the patient-positioning system and enabling technologies use to perform surgery. Furthermore, the surgical componentry can be used to locally articulate the patient's body and/or the stabilize patient's spine. Surgical methods of using the patient-positioning system, the computer-control and data-integration system, and the surgical componentry for improving patient health outcomes are also provided.

Abstract: A patient support apparatus for supporting a patient in a prone position during a surgical procedure is provided, including an open fixed frame suspended above a floor and a pair of spaced opposed radially sliding joints cooperating with the frame, each joint including a virtual pivot point and an arc of motion spaced from the virtual pivot point, the joints being movable along the arc providing a pivot ship mechanism for a pair of pelvic pads attached to the joints. A base for supporting and suspending a patient support structure above the floor, for supporting a patient during a surgical procedure, the base including a pair of spaced opposed vertical translation subassemblies reversibly attachable to a patient support structure, a cross-bar, and a rotation subassembly having two degrees of rotational freedom; wherein a location of each vertical translation subassembly is substantially constant during operation of the patient support structure.

Abstract: An apparatus for powering a manual wheelchair with rear wheels that includes a motor and pair of powered drive wheels, with each powered drive wheel in contact with a respective rear wheel of the manual wheelchair. Some embodiments of the powered apparatus include a piston assembly coupled to each of the powered drive wheels, whereby movement of the piston assembly to a disengaged position ceases motorized control of the wheelchair. The piston assembly may also be utilized as a “build-in” emergency stopping feature for motorized wheelchairs. A controller for operating the powered apparatus also is contemplated.

Abstract: A wheelchair lift apparatus includes a vertical lift rail attached to a front frame of the wheelchair, a support plate slidably engaged with the lift rail and extending horizontally forward, and an actuator for moving the support plate along the lift rail. The wheelchair lift apparatus enables a person to move from sitting on the ground to sitting on the wheelchair, and vice versa, without using his/her legs and without assistance from another person. With the support plate lowered onto or near the ground, a person can maneuver, without using his/her legs, between sitting on the ground or on the support plate. With the support plate raised to flush with the wheelchair seat, the person can maneuver, without using his/her legs, between sitting on the wheelchair seat or on the support plate. The support plate can be positioned along the lift rail to act as a footrest.

Abstract: A female urination assistance apparatus for use by any women that can be easily fixed on a chair is disclosed. The apparatus may comprise a base layer for placing on the top of the chair. A lower foam assembly fixed on top of the base layer contains plurality of channels for positioning of collection tube for transferring the urine. The collection fittings comprising of an inlet portion, an outlet portion and the collection tube are disposed of in the lower foam assembly. Further, a silicon support is present to secure the inlet portion of the collection fittings. Furthermore, a collection funnel retained in the silicon support is also provided which has an opening for the outflow of urine. The entire structure is covered by a flap closure cover with gel insert. The gel insert provides the interface between the user and the apparatus.

Abstract: A wheel lock device includes a base, a first arm, and a second arm. A base/first-arm mating portion includes a base/first-arm mating portion cross-sectional profile that changes along a length of the base/first-arm mating portion. A base/second-arm mating portion includes a base/second-arm mating portion cross-sectional profile that changes along a length of the base/second-arm mating portion. The first arm includes a first-arm/base mating portion that includes a first-arm/base mating portion cross-sectional profile that changes along a length of the first-arm/base mating portion in a direction toward the first-arm first aperture in a manner complementary to the base/first-arm mating portion cross-sectional profile.

Abstract: Various implementations include a device for moving a person on a support apparatus. The device includes a base, an expandable volume, and a sheet. The base has a first side, a second side, and a support apparatus coupler for coupling the device to a support apparatus. The expandable volume is disposed on a surface of the base between the first side and the second side and is actuatable from a first position to a second position. The sheet has a first portion that is stationary with respect to the base and a second portion. The sheet extends from the first portion, over the second side, over the expandable volume, and over the first side. Actuation of the expandable volume from the first position to the second position increases a length of the sheet extending from the second side of the base to the first side of the base.

Abstract: A system and method is provided for a wearable robotic upper body garment. In an embodiment, an upper body garment or apparatus comprises a shoulder saddle, one or more actuators, one or more flexible tendons, back torso section, front, torso section, torso wrap, and upper arm cuff. The shoulder saddle may be comprised of a yoke and one or more elevated shoulder sections. The one or more elevated shoulder sections may be comprised of a first elevated shoulder section. In an embodiment, the back torso and front torso sections may be structurally connected to the yoke. In an embodiment, the one or more actuators may be structurally connected to either said back torso section or front torso section. In an embodiment, the one or more flexible tendons may be operationally connected to a predetermined one or more actuators and an upper arm cuff.

Abstract: A wearable multifunctional powered exoskeleton for cervical vertebra rehabilitation, and relates to the field of man-machine interaction rehabilitation aids, comprises an active drive motor module, a fixed supporting module and a movable joint component; wherein the active drive motor module is connected to the fixed supporting module, and comprises a left shoulder push rod motor, a right shoulder push rod motor, a cervico-thoracic vertebra left front side push rod motor, a cervico-thoracic vertebra left rear side push rod motor, a cervico-thoracic vertebra right front side push rod motor, and a cervico-thoracic vertebra right rear side push rod motor; wherein the active drive motor module and the movable joint component are combined to Jointly form a six-connecting rod power-driven structure.

Abstract: A system and method for controlling the speed of operation of sexual stimulation devices from videos of sexual activity using a less computationally intensive method of estimating movement speed from a video. In an embodiment, the system and method involve estimating movement in a video using pixel-by-pixel color change over time, calculating a rate of color change in the video, estimating a speed of movement in the video from the rate of color change, and applying an algorithm to convert the estimated speed of movement in the video to a speed of operation of a sexual stimulation device.

Abstract: A system and method for controlling sexual stimulation devices using motion-sensing controllers. The system comprises a male sexual stimulation device and a motion sensing controller configured to control the operation of the reciprocating linear motion driver. In operation, natural motions of a user with the motion sensing controller result in corresponding motions of the male sexual stimulation device such as reciprocal linear motions and rotational motions.

Abstract: A stimulation device includes a rotary member, a fixing member, a sliding member and a swinging unit. The rotary member defines a first groove therein, wherein the first groove is annular and non-circular. The fixing member defines a second groove therein, wherein the second groove is linear-shaped. The sliding member includes a first sliding portion being slidably engaged into the first groove and a second sliding portion being slidably engaged into the second groove. The swinging unit includes at least one swinging bar being rotatably connected to the sliding member.

Abstract: A treatment system includes a treatment device adapted to contact a vulvar or vaginal tissue of a body and includes a treatment mechanism configured to apply a treatment to the tissue and at least one sensor configured to provide objective sensor data related to the tissue. An external device is configured to receive subjective information provided by a user or a third party and to receive the objective sensor data from the treatment device. The external device includes a processor configured to use the subjective information and the objective sensor data in a decision matrix to issue commands to at least the treatment mechanism that correspond to treatment instructions based on the subjective information and the objective data. The treatment instructions include instructions related to controlling the treatment mechanism and its application of treatment to the tissue and a treatment duration.

Abstract: A walking roller assembly includes a leg sling for receiving a patient's lower leg and pair of roller frames each attached to the leg sling. Each of the roller frames has a curved member which engages a support surface upon which the patient is walking. Thus, each of the roller frames inhibits the patient's lower leg from supporting the patient's body weight to facilitate a leg injury to heal. The curved member of each of the roller frames curves downwardly with respect to the leg sling thereby facilitating the leg sling to rock when the patient walks thereby simulating the patient's normal gait. A leg panel is pivotally attached to the pair of roller frames and the leg panel is oriented at an angle with the leg sling. In this way the leg panel can receive the patient's upper leg and orient the patient's leg in a bent position.

Abstract: A cover for a walking frame including: a central crossmember portion, a left arm portion, and a right arm portion; said left and right arm portions including a receptacle defined by an inner flap and an outer flap on each of said left and right arm portions; and wherein said central crossmember portion includes at least one fastener pair for securing said central crossmember portion.

Abstract: A walking assist device includes a vertical support with a proximal end and a distal end, the proximal end coupled to a seat for supporting a user's hip with the user's thigh in a generally horizontal position and a seat attachment member to secure the user's thigh to the seat. The distal end of the vertical support comprises a foot for transferring weight from the user's hip to the ground with the user's thigh in a generally horizontal position. An optional horizontal support extends from the vertical support between the proximal end and the distal end of the vertical support and includes a calf support member.

Abstract: A one handed walk assist device featuring a handle and plurality of legs affixed to a variably shaped support frame, featuring various independent embodiments including an embodiment trapezoidal orientation between the front and back legs, and an embodiment apparatus orientation that is angled backwardly. A variety of storage/carriage compartments are disclosed.

Abstract: A solid bar comprising a personal care composition and having at least one working feature for soft tissue mobilization, the working feature being a structural feature as found on a physical therapy soft tissue mobilization tool that is adapted to mobilize soft tissue.

Abstract: A blood flow stimulator may help encourage blood flow in a limb of a patient. The blood flow stimulator may include a housing configured for sealing about the limb of the patient. The housing may include a sealable volume, and the sealable volume may receive the limb of the patient. The blood flow stimulator may include a seal, and the seal may be coupled with the housing. The seal may engage with at least a portion of the limb, for instance to segregate the sealable volume from a surrounding environment of the blood flow stimulator. The blood flow stimulator may include a conduit extending through the housing. The conduit mat help provide access to the sealable volume, for instance from the surrounding environment. In some examples, an adjustable stent is utilized to enhance blood flow within vasculature of a patient. A stent operator may change a size of the stent.

Abstract: Disclosed is a septum holder for use in a connector section of a fluid transfer apparatus for the transfer of a drug from one container to another. The septum holder comprises a body part and a septum support that are moveable in relation to each other. A septum is attached to the septum support. The body part and septum support are configured to be locked to each other at the end of a movement that brings them to their closest positions to each other.

Abstract: A fixing device of a nasogastric tube contains: an adhesion member, a connection member, and a retainer. The adhesion member includes an adhesive face, a circular column, and an engagement portion. The connection member includes a connecting sheet, a locating post, and a spherical portion. The connecting sheet has a rectangular slot and an annular orifice, such that the annular orifice accommodates the engagement portion of the adhesion member, the rectangular slot slidably receives the circular column of the adhesion member, an end of the connecting sheet proximate to the annular orifice is connected with the locating post, and the other end of the locating post is connected with the spherical portion. The retainer includes a coupling bar and a joining knob. The retainer further includes a clamp section and two press portions. Furthermore, the clamp section has a hollowly circular space defined therein.

Abstract: A storage container for a storage and dispensing station for a blister machine for separable small piece goods, such as drug portions and food supplement portions, and a storage and dispensing station are provided. The storage container includes a housing having an inside circular-cylindrical portion, a separating device arranged in the inside circular-cylindrical portion having a surface, as well as a retaining assembly. The separating device includes an electrically dischargeable discharging device, the discharging device having at least one discharging projection extending from the surface of the separating device as well as a discharging contactor coupled in an electrically dischargeable manner to the at least one discharging projection for electrically coupling the discharging device to an electrically dischargeable component of a dispensing station coupled to the storage container, the dispensing station having a drive.

Abstract: Provided are a pharmaceutical composition and a method for treating a microbial infection in a subject in need thereof. In some cases, the composition comprises at least about 10% of thujopsene and at least about 10% of totarol. The present disclosure also provides a pharmaceutical composition and a method for treating a viral infection in a subject in need thereof. In some cases, the method comprises administering to the subject in need thereof a therapeutically effective amount of a composition comprising at least about 10% of thujopsene.

Abstract: Provided are methods of using curcuphenol compounds to increase expression of major histocompatibility complex class I (MHC-I) antigen in cells, particularly on the surface of diseased cells such as cancer cells, and thereby increase the immunogenicity of the cells. Also provided are pharmaceutical compositions that comprise curcuphenol compounds and methods of use thereof, for instance, to treat various cancers, alone or in combination with other therapies.

Abstract: Provided herein are novel synthetic compounds having the structure of formula (1), wherein X is a substituted or unsubstituted aromatic or heteroaromatic mono- or polycyclic ring system; and Y is substituted or unsubstituted C5-C10 alkyl or alkenyl group, or a pharmaceutically acceptable salt thereof. Also provided are pharmaceutical compositions. The compounds and pharmaceutical compositions are useful for inhibiting growth of a bacterium.

Abstract: The present invention relates to methods for treating uterine hypercontractility disorders. in particular, the present invention relates to methods for treating abnormal uterine bleeding and dysmenorrhea comprising administering to women suffering from such disorders a pharmaceutical composition comprising an S-alkylisothiouronium derivative.

Abstract: The present disclosure relates to methods for treating plexiform neurofibromas associated with neurofibromatosis type 1 (NF1-PN), comprising administering to a pediatric patient (e.g., 2 to 15 years of age) in need thereof mirdametinib or a pharmaceutically acceptable salt thereof.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: X-A-Y-L-R??(I) which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: Methods are disclosed for treating and/or preventing a neurological condition, such as neural injury or neurological disorder, in a subject through metabolic regulation of mitochondria using compounds that are natural metabolites, metabolite analogs, or derivatives of natural metabolites to modulate biochemical pathways comprising succinate and/or succinate dehydrogenase, thereby reducing microglial cell and/or astrocyte activation. Compounds and related formulations are also provided to modulate the biochemical pathways comprising succinate and/or succinate dehydrogenase for reducing or inhibiting microglial cell and/or astrocyte activation.

Abstract: The invention features methods of treating cancer with ?-GPA. The disclosure also provides methods of treating cancer including combinations of ?-GPA and additional anti-cancer therapies.

Abstract: A method of stimulating ventilatory and/or respiratory drive in a subject in need thereof includes administering to the subject a therapeutically effective amount of a composition comprising an glutathione alkyl ester, adduct thereof, or pharmaceutically acceptable salt, tautomer, or solvate thereof.

Abstract: The present disclosure targets West Nile virus, Respiratory Syncytial Virus, Influenza viruses such as Avian influenza, and other disease-causing microbes, including viruses, bacteria, fungi, and parasites. It does this using agents and methods with little toxicity compared to existing therapies.

Abstract: The present disclosure provides pharmaceutical compositions comprising a cannabinoid, and dosage forms comprising same, for oral delivery, such as sublingual or buccal delivery. The compositions of the present disclosure are substantially homogeneous and remain stable and monophasic upon storage. Also provided are methods of using the compositions for pain management and to treat various diseases and conditions, including dementia, sleep disorders, movement disorders, mental disorders, and multiple sclerosis.

Abstract: A pharmaceutical composition containing forskolin and retinoic acid as active ingredients which is suitable for preventing or treating sensorineural hearing loss is disclosed. A pharmaceutical composition containing forskolin and retinoic acid as active ingredients has an excellent effect of preventing, alleviating or treating hearing loss caused by ototoxic drugs during anticancer treatment, and thus is useful as a pharmaceutical composite preparation capable of reducing side effects of anticancer drugs and, additionally, as an agent for preventing or treating sensorineural hearing loss.

Abstract: A method of modulating ribonucleotide reductase activity in a neoplastic cell includes administering to the cell an amount of a hydrazone or hydrazine ribonucleotide reductase modulator (RRmod), the amount being effective to inhibit neoplastic cell growth.

Abstract: The invention relates to a new class of compounds targeting COX-1. The invention also relates to the use of some of such compounds as a tool to investigate the structure and function of the enzyme, in the treatment targeting COX-1 or detection of COX-1 in relating disorders or diseases such as cancer and neuroinflammation, in particular in neurological (e.g. autism spectrum disorders) and neurodegenerative diseases (e.g. Alzheimer's diseases, Parkinson's diseases, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), traumatic brain injury (TBI), HIV dementia and prion diseases), and in gynecological tumor (e.g. ovarian cancer), neck and head tumor, and haematological tumors (e.g. multiple myeloma) and in the detection of COX-1 in “in vitro” (cells and tissues) and in “in vivo”.

Abstract: The present disclosure relates to improved methods of treatment with nirogacestat.

Abstract: The present disclosure relates to improved methods of treatment with nirogacestat.

Abstract: The present invention is related to compounds, methods, compositions and uses that are able to restore responsiveness to immunotherapy, in particular immune check point inhibitors or anti-cancer vaccine or to anti-angiogenesis treatment.

Abstract: An improved method is provided for treating a patient having a disorder responsive to PDE-4 inhibition by administering roflumilast. The improvement involves administering the roflumilast topically in a composition having a roflumilast release profile that produces in the patient a flattened plasma concentration time curve and a reduced Cmax relative to oral administration of a PDE4-inhibiting amount of roflumilast. Such disorders include inflammatory disorders such as inflammatory dermatoses, including psoriasis, atopic dermatitis and seborrheic dermatitis. Such disorders also include inflammatory diseases in a variety of organs, especially the lungs (asthma, COPD). Because of reduced side effects with topical administration due to the improved pharmacokinetics (PK) characteristics, it may be possible to provide higher systemic exposures (AUCs) with topical administration, resulting in greater therapeutic efficacy than with the oral route of administration.

Abstract: The inventors have found that the compounds of formula (I) protect cardiomyocytes. Accordingly, the disclosure provides a pharmaceutical composition for protecting a cardiomyocyte comprising a compound of formula (I) or an ester, oxide, pharmaceutically acceptable salt or solvate thereof. The pharmaceutical composition may be used for treating or preventing a disease associated with cardiomyocyte death, such as myocardial infarction, chronic heart failure, hypertensive heart failure, or dilated cardiomyopathy, especially for treating myocardial infarction.

Abstract: The present disclosure is drawn to the combination therapy of a C-C Chemokine Receptor 4 (CCR4) antagonist and one or more immune checkpoint inhibitors in the treatment of cancer.

Abstract: The present disclosure relates to a ready-to-administer (RTA), intravenous (IV) bag presentation for hydromorphone. In particular, the present disclosure relates to terminally sterilized liquid formulations comprising hydromorphone hydrochloride in sodium chloride packaged in an RTA IV bag. The present disclosure also relates to methods of treating patients by administration of such formulations and RTA IV bags containing such formulations.