Abstract: Described herein are immunoconjugates comprising an: a) antigen binding region; b) an immunoglobulin heavy chain constant region; and c) a radioisotope chelating agent; wherein the molecular weight of said immunoconjugate is between 60 and 110 kDa. The immunoconjugates can be used to deliver alpha and beta emitters for the treatment of tumors or cancer.

Abstract: A conjugate of an anti-epidermal growth factor receptor (EGFR) antibody site-specifically modified with a peptide and a chelating agent. The chelating agent is chelated with a metal radionuclide, the peptide and the chelating agent are linked by a linker (L), and the linker (L) does not contain a thiourea bond.

Abstract: A conjugate of an anti-CD20 antibody and a chelating agent. The chelating agent is chelated with a metal radionuclide, the anti-CD20 antibody and the chelating agent are linked by a linker (L), and the linker (L) does not contain a thiourea bond. A radiopharmaceutical containing the conjugate as an active ingredient.

Abstract: A vibration apparatus includes a base member, a protection member, and a vibration generating part configured between the base member and the protection member to output an ultrasound, wherein the vibration generating part includes a plurality of first signal lines and a plurality of second signal lines configured on the base member to intersect with one another and a plurality of vibration parts disposed at intersections of the plurality of first signal lines and the plurality of second signal lines.

Abstract: Systems and methods for disinfection of aircraft cabins, including galleys and lavatories. The embodiments may use UVC light sources having a wavelength between 200-230 nm for efficiently inactivating pathogens without harm to exposed mammalian skin or eyes.

Abstract: A surface-contaminated sanitizing apparatus is configured to emit energy, particularly user-safe 222 nanometer UV light, for sanitizing a surface, such as, a door handle, a bank of elevator floor selectors, and other potentially unsanitary surfaces that human beings touch repeatedly. This apparatus may be configured to operate automatically in response to detection of a user's finger or hand contacting/touching/nearing such a surface, and to sanitize the surface after any such contact.

Abstract: A disinfection device system of a building comprising: a controller comprising at least one processor and at least one memory having instructions stored thereon that, when executed by the at least one processor, are configured to cause the at least one processor to: monitor one or more conditions of a space in the building; and selectively activate and deactivate at least one Far UV-C disinfection device installed in the space using the conditions of the space and one or more of an energy budget, a target total operating cost, or a net emissions target, wherein the Far UV-C disinfection device comprises at least one Far UV-C light source structured to output disinfecting light at a wavelength between 200 nm and 230 nm.

Abstract: According to some embodiments, a condiment sterilizer can include: a base, a lid attached to the base and configured to move between an open position and a closed position, and a condiment tray mounted in the base. The base and the lid define an internal chamber when the lid is in the closed position. The condiment tray can include a center column, and one or more compartments disposed around the center column and configured to accommodate one or more condiment containers. The condiment sterilizer can further include at least one UV light device disposed on the center column and configured to emit UV light into the internal chamber. The condiment sterilizer can further include a controller configured to cause the lid to move from the closed position to the open position, and to raise the condiment tray, in response to a sensor sensing heat or motion.

Abstract: Provided are an ultraviolet irradiation device that can effectively inactivate pathogens while ensuring safety for a human body, a method for using the irradiation device, and the ultraviolet irradiation method. The ultraviolet irradiation device according to the present invention includes: a light source that emits ultraviolet light having a main emission wavelength belonging to a range from 190 nm to 240 nm; a housing that accommodates the light source; an extraction part that extracts the ultraviolet light emitted from the light source to the outside of the housing; and a diverging optical system that enlarges a light distribution angle of the ultraviolet light passing through the extraction part.

Abstract: A safety cabinet can include an enclosure defining an interior compartment accessible through an opening. The safety cabinet includes an interior lighting system. The interior lighting system can include at least one of an illuminating light to enable viewing to cabinet contents and an ultraviolet light configured to disinfect the interior compartment of the safety cabinet. To provide electrical power to the interior lighting system, the safety cabinet includes an electrical connection disposed through the enclosure. The electrical connection can include at least one of a bulkhead connector and an intumescent socket.

Abstract: Embodiments of a unified airflow system for ultraviolet disinfection devices are disclosed. One embodiment of the present disclosure includes a unified airflow assembly and a control unit. The unified airflow assembly provides a shared airflow passage between a UV source and an airflow accessory capable of extracting contaminants from a target surface using a suction airstream. The UV source may be fluidically disconnected from the airflow accessory. The unified airflow assembly may include at least one air restriction unit in the shared airflow passage for manipulating a suction airstream therein. The control unit may be configured to drive the at least one air restriction unit to restrict the suction airstream to only one of the UV source and the airflow accessory.

Abstract: Provided is a plasma treatment apparatus that does not use a separate process gas by discharging low-pressure atmosphere formed in a sealed space in which a plasma surface treatment is performed. Therefore, by discharging the low-pressure atmosphere using a relatively low voltage, stable plasma with high surface treatment efficiency may be generated, and thus a plasma treatment apparatus may be configured economically and no operation and management costs due to the use of a process gas are incurred. Also, the safety and the effectiveness of a plasma surface treatment process to be applied in the medical industry are secured, and sterility may be secured and usability may be maximized.

Abstract: A method and an apparatus are provided for cleaning, disinfecting, and/or sterilizing a device. The method comprises contacting an object with an obstructing substance such that the object is infiltrated with at least a portion of the obstructing substance. An absorptive and/or adsorptive capacity of the object is reduced by the obstructing substance. The object is contacted with a treatment agent after the capacity of the object is reduced. Infiltration of the object with the treatment agent is limited by the reduction of the capacity of the object.

Abstract: Systems and methods are disclosed that disinfect a populated venue/space in real-time by autonomously employing directed disinfecting light/radiation. One embodiment comprises an ultraviolet (UV) light source which may comprise coherent and incoherent light sources that disinfect surfaces of pathogens; a set of sensors collecting data correlating to characteristics of a plurality of objects and events in the space; a controller that receives data from the set of sensors; identifies areas to be disinfected; identifies whether the UV light source has a clear line-of-sight path to irradiate the area; and sends control signals to the light source to control the application of disinfecting light to areas in the space.

Abstract: Embodiments of the invention relate to room treatment devices, systems, and methods for sanitizing rooms and communicating emergency conditions in a wireless network formed between the room treatment devices.

Abstract: Described herein are systems and methods for treatment of various airborne or surface-associated contaminants in which UV aerosol technology is combined with the use of hydrogen peroxide vapor or aerosol to create potent airborne concentrations of reactive oxygen-containing radicals that react with the airborne or surface-associated contaminants to inactivate, disinfect, oxidize, rearrange, ablate and/or otherwise treat these materials and thereby achieve disinfection of indoor air and/or surfaces. This technology is referred to herein as peroxide-enhanced germicidal irradiation (PEGI).

Abstract: Disclosed embodiments may include a fragrance diffusing device including a fragrance reservoir and a vessel. The vessel may include a first substantially impermeable layer defining an internal space and comprising one or more openings; and a semi-permeable layer disposed within the internal space of the first substantially impermeable layer. The fragrance reservoir may be configured to be placed within the vessel with the semi-permeable layer disposed between the first substantially impermeable layer and the fragrance reservoir.

Abstract: The present invention discloses a fragrance machine, including a housing and an atomizing assembly. A limiting pipe is fixed in the housing; the limiting pipe is communicated with atmosphere outside the housing; an atomizing pipe and a liquid storage bottle are inserted in the limiting pipe; an atomizing core is fixed on the atomizing pipe; through holes are formed on the atomizing pipe; the liquid storage bottle is fixed with the atomizing pipe; the atomizing core and the through holes are limited at an inner side of an opened end of the liquid storage bottle; the atomizing core is provided with a liquid spray hole and an air spray hole which are arranged perpendicularly; the liquid spray hole is communicated with the interior of the liquid storage bottle; an air pump is communicated with the air spray hole; and a power supply is electrically connected with the air pump.

Abstract: The present invention relates to a fluid treatment module and a fluid treatment apparatus comprising same. In particular, according to an embodiment of the present invention, provided is a fluid treatment module comprising: a housing portion having a space formed therein for allowing a fluid to flow in the vertical direction, and having an inlet port for introducing the fluid there and a discharge port for discharging the fluid introduced therein to the outside; a light source portion which can irradiate light to the fluid flowing in the housing portion; and a fluid guide portion which guides the flow of fluid introduced in the housing portion and of which one side is opened in a direction misaligned from the direction in which the inlet port is opened and the other is in communication with the discharge port.

Abstract: A kit of gel-forming solutions for a preparation of a biodegradable hydrogel based on a covalently crosslinked hydroxyphenyl derivative of hyaluronan is provided. The kit comprises at least two aqueous solutions, A and B, wherein the solution A comprises horseradish peroxidase and the solution B comprises hydrogen peroxide. At least one of the solution A and/or the solution B comprises a hydroxyphenyl derivative of a hyaluronan, and at least one of the solution A and/or the solution B comprises triclosan and hydroxypropyl-?-cyclodextrin. A method of preparing a hydrogel containing a covalently crosslinked hydroxyphenyl derivative of hyaluronan, from the kit, is also provided. The method comprises preparing separately the at least two solutions A and B, and mixing together the solution A with the solution B to form the hydrogel containing a covalently crosslinked hydroxyphenyl derivative of hyaluronan.

Abstract: A method of producing a bioactive surface on a medical device configured for cementless implantation is disclosed. The method can include treating a titanium metal or titanium alloy medical device, optionally having a titanium metal or titanium alloy porous coating, with a series of steps to obtain the bioactive surface having a nanofibrous network of titanate overlaid with hydroxyapatite particles or film. The steps can include treating the medical device with an acidic solution to obtain an activated surface; oxidizing the activated surface using plasma electrolytic oxidation to obtain an oxide layer having bioactive elements, compounds, or phases; treating the oxide layer with an alkaline solution to obtain the bioactive surface; and treating the bioactive surface with an iodine containing compound to obtain an antibacterial and bioactive surface.

Abstract: The present invention relates to a therapeutic drug for a disease accompanied by a disorder in retinal cells or a retinal tissue, the drug including a retinal tissue, the retinal tissue being of an allogeneic origin and having a three-dimensional structure, wherein an intended patient to be given the therapeutic drug is a patient affected by a disease accompanied by a disorder of retinal cells or a retinal tissue, to be given systemically, for 1 month or more after the administration of the therapeutic drug, no immunosuppressive agent aimed at preventing graft rejection.

Abstract: The present disclosure relates to methods for preparing car cartilage for eyelid reconstruction, including upper eyelid reconstruction, after trauma, disease, or tumor excision. The present disclosure also relates to compositions, uses, and methods for reconstructing an eyelid. The present disclosure also relates to kits for preparing ear cartilage for eyelid reconstruction. The disclosed compositions, uses, kits, and methods may also be used for autograft, allograft, isograft, and xenograft transplantation, for stored or banked grafts, and for other therapeutic uses.

Abstract: The present disclosure provides citrate-based constructs for use in the repair of osteochondral defects. The constructs generally include: (i) a citrate component, (ii) a diol component, (iii) a polyol, and (iv) particulate inorganic material. The scaffold may take the form of a 50-90% porous scaffold and may form a polymer network. The scaffold may be soaked in a hyaluronic acid solution and may be freeze-dried to produce a porous construct within the pores of the scaffold. The scaffold may be biphasic, containing a porous section for subchondral bone regeneration and a citrate-based polymer hydrogel for cartilage regeneration. The scaffold may form an implant and the implant may include an inner porous core of a biphasic core-shell construct.

Abstract: Disclosure herein are an implantable cell containing device, its subcomponent scaffold, methods of making the same and their methods of use. The implantable cell containing device includes a scaffold and a cell-containing hydrogel encapsulating the scaffold. The scaffold has a tracheal-like internal system of continuous air-filled, hydrophobic micro-channels that traverse the scaffold's dimensions and a hydrophilic external surface. The implantable cell containing device, when implanted in a subject, can be used for delivering a therapeutic agent to a subject in need thereof for the treatment of various conditions and diseases.

Abstract: The present disclosure is directed to viable bioengineered allogeneic cellularized construct.

Abstract: The present disclosure provides a variety of methods and compositions e.g., solutions) useful for making, sterilizing, and preserving tissues (e.g., acellular tissue matrices). The disclosure also features the acellular tissue matrices made by the methods, which matrices can be used for a variety of applications such as, but not limited to, treating an injury to, or repairing, a large number of tissues and/or organs (e.g., fascia, bones, and/or cartilage) in a mammal (e.g., a human).

Abstract: The present disclosure relates to a porous inorganic particle which comprises a sintered body of calcium-based particles, and pores distributed in the sintered body, and has a core-shell structure of a core having a high porosity and a shell having a porosity lower than that of the core, wherein the calcium-based particles comprise first calcium-based particles having a maximum diameter of 10 nm to 500 nm, and second calcium-based particles having a maximum diameter of 1 ?m to 10 ?m, and to a composite fillers and product using the same.

Abstract: A one-piece integrally moulded device includes a tubular part (2) having a distal end (5). a proximal end (4) and a hand grip (10). An inlet opening (3) at the proximal end allows drainage of urine through an outlet opening (6) at the distal end. A closure (7) is connected to the tubular part by a first hinge (8) for closing the outlet opening (6). The device is moulded from a vinyl alcohol polymer with the chemical formula [CH2CH(OR)]n where R?H or COCH3, with the COCH3 groups being randomly distributed throughout the molecule. The material has a degree of hydrolysis from 85-89% and is water soluble down to 10 degrees Celsius.

Abstract: The presently-disclosed subject matter includes a compound comprising a first monomer, which is allyl-functionalized and crosslinkable, and a second monomer, which is not crosslinkable. In some embodiments the compounds are photocrosslinkable, and in certain embodiments are photo crosslinkable by ultraviolet light. Also provided are shape memory vascular grafts comprised the of present compounds that can transition from a temporary shape to an original shape when heated above a melting temperature of the graft. Still further provided are methods for treating vascular conditions that utilize embodiments of the present grafts.

Abstract: Provided are a drug-eluting medical device in which drug elution is sustained release and the peeling durability of the coating layer is high, and a method for producing the same. A drug-eluting medical device including: a substrate; a first coating layer coated on the substrate and having a first polymer obtained by autoxidation polymerization of a dopamine molecule or an analog thereof; a second coating layer coated on the first coating layer having a second polymer covalently bonded to the first polymer; and a third coating layer coated on the second coating layer and having a drug and a third polymer supporting the drug, wherein the second polymer and the third polymer form an interpenetrating polymer network structure.

Abstract: A breast pump shaped at least in part to fit inside a bra and having a housing, a breast shield including a nipple tunnel adapted to receive a nipple and further including a milk compartment adapted to contain a predetermined amount of expressed milk, a working fluid chamber assigned to a vacuum source and a pumping chamber in fluid communication with the nipple tunnel, wherein the working fluid chamber and the pumping chamber are fluidically separated from each other by a membrane. For providing a breast pump which can be manufactured and assembled by handling a reduced number of parts, the present invention proposes to define the housing, the milk compartment, the working fluid chamber, and the pumping chamber by only three components.

Abstract: The present disclosure relates to a method for controlling a blood treatment apparatus when air bubbles or air pockets are present in an extracorporeal blood circuit connected to the blood treatment apparatus, which have been detected by an air bubble detector. It further relates to a control device or closed-loop control device and a blood treatment apparatus by which the method described herein is brought into effect, a digital storage medium, a computer program product, and a computer program.

Abstract: A method for producing a blood filter, the blood filter being a filter for filtering blood, the method comprising providing a first layer; providing a block copolymer layer above the first layer; converting the block copolymer layer to a mask by selectively removing domains of the block copolymer layer; etching pores through the first layer in regions exposed by the mask; wherein a pore size is below 20 nm, the pore size preferably being 6.6 nm or smaller.

Abstract: A medical fluid container tubing assembly includes a medical fluid container, a first luer connector, a tube extending from the medical fluid container and terminating at the first luer connector, and a cap fitted onto the first luer connector. The cap includes a hydrophobic filter positioned and arranged to allow air to aseptically enter the tube to equalize pressure inside and outside of the tube. The medical fluid container tubing assembly also includes a supply line extending from a medical fluid destination and terminating with a second luer connector. The second luer connector is configured to mate with the first luer connector when the cap is removed from the first luer connector.

Abstract: A method for performing port cleaning of an apparatus having a casing, a fluid circuit enclosed inside the casing, and a port arrangement. The method includes producing a cleaning fluid with the fluid circuit; passing the cleaning fluid through a first port via a first tube of the first port to a first circumferential space, from the first circumferential space via a bypass channel to a second circumferential space, and thereafter to a second tube of a second port; and passing the cleaning fluid from the second tube to a drain.

Abstract: An example peritoneal dialysis system is disclosed. The example peritoneal dialysis system includes at least one pump and a memory device configured to store therapy prescriptions including a first ultrafiltration (“UF”) therapy prescription for removing ultrafiltrate from a patient, and a second UF therapy prescription for removing less ultrafiltrate from the patient compared to the first UF therapy prescription. The system further includes a logic implementer configured to receive UF removed data, use the UF removed data to form or update a moving average UF removed trend, and compare the moving average UF removed trend to an expected UF removal trend or an expected UF removal minimum value. When the moving average UF removed trend is below the expected UF removal trend or the expected UF removal minimum value, the logic implementer provides a recommendation that the first UF therapy prescription should be selected for a next peritoneal dialysis treatment.

Abstract: A patient monitoring system may be used with catheters to monitor the infusion and drainage of any solution into the human body. The system may be used, for example, with in-dwelling catheters for peritoneal dialysis in end stage renal disease (ESRD) patients, urinary tract catheters, insulin pumps in diabetic patients, feeding tubes and central venous line catheters. The patient monitoring system includes one or more fluid pathways for infusing into and/or draining solutions out of the catheter, and one or more sensors to monitor the fluid. The patient monitoring system transmits the patient monitoring data to a database, allowing data storage, processing, and access through graphical user interfaces to patients and providers via device applications or browser-based web access portals.

Abstract: A dialysis sheath is used with a catheter that cleans clots from a synthetic blood vessel or fistula. The dialysis sheath comprises a main hollow body and a stop mechanism. The main body has a lower portion for insertion into the synthetic blood vessel or fistula. The stop mechanism is movable between (i) a first position in which the stop mechanism is adjacent to or within a surface of the main hollow body and (ii) a second position in which the stop mechanism radially protrudes from the main hollow body. The stop mechanism is configured to engage an inner surface of the synthetic blood vessel or fistula to maintain the lower portion of the dialysis sheath within the synthetic blood vessel or fistula when the dialysis sheath is moved to a different position. The stop mechanism can be fluid-actuated and include a balloon-like structure.

Abstract: A pumping system for a phacoemulsification system, consisting of: a phacoemulsification probe, an irrigation tube providing irrigation fluid into an eye, an irrigation pump pumping the irrigation fluid, an aspiration tube conveying aspiration fluid from the eye, an aspiration pump pumping the aspiration fluid from the eye, an aspiration pump sensor providing a first signal indicating activation of the aspiration pump, and a pressure sensor providing a second signal indicating intraocular pressure (IOP) in the eye. A controller receives the first signal and second signals, and in response controls the irrigation pump to alter a registered flow rate of the irrigation fluid to a preset adjusted flow rate until a threshold, dependent on at least one of a time of operation of the irrigation pump at the preset adjusted flow rate and the second signal, is crossed. When crossed the irrigation fluid is pumped at the registered flow rate.

Abstract: A chest drainage system including a collection device configured to receive fluid from the pleural cavity of a patient. A sensor is included to detect a pressure differential in the fluid. A display is configured to display a trend in occurrences of changes in pressure of the fluid over time in predetermined time increments based on a number of detections of pressure differentials that exceed a predetermined pressure differential during each of the predetermined time increments. The trend is correlative to the percentage of time that the patient is deemed to have an air leak in the pleural cavity in the predetermined time increments. The trend is derived from a ratio of the quantity of respiratory cycles of the patient for which the predetermined pressure differential is detected (QRCleak) in the predetermined time increments to the total quantity of respiratory cycles of the patient in respective predetermined time increments (QRCtotal).

Abstract: A phacoemulsification probe includes an irrigation sleeve configured to fit over a hollow aspiration needle and a probe body, the irrigation sleeve to provide a fluid pathway for the flow of irrigation fluid between the needle and the walls of the irrigation sleeve, the sleeve having a distal end insertable into an incision made in an eye, the distal end having ports to release said irrigation fluid into said eye, where the walls of the irrigation sleeve have at least one anti-tortional element longitudinally placed along a length of the irrigation sleeve to provide structural support to prevent twisting of the sleeve and where the at least one anti-tortional element allows flattening of the irrigation sleeve for maneuvering of the sleeve within the eye while preserving the integrity of the incision.

Abstract: A wound therapy system includes a dressing an instillation pump fluidly communicable with the dressing and configured to provide instillation fluid to the dressing, a negative pressure pump fluidly communicable with the dressing and configured to remove air from the dressing, and a control circuit communicably coupled to the instillation pump and the negative pressure pump. The control circuit is configured to control the instillation pump to provide an amount of the instillation fluid to the dressing, provide a soak period, and control the negative pressure pump to provide a cyclic variation of negative pressure at the dressing.

Abstract: Guided relay infusion systems and methods are provided. The guided relay system may be a portion of an infusion pump that can simultaneously deliver a medical fluid from two syringes. When a first one of the syringes is running out of the medical fluid and a second one of the syringes is more full of the medical fluid than the first one of the syringes, guided relay messages are provided for a relay handoff from the first one of the syringes to the second one of the syringes that ensures a smooth continuous delivery of more of the medical fluid than the first one of the syringes holds.

Abstract: An insulin injection pump, a manufacturing method of an insulin injection pump and a closed-loop system is provided. The insulin injection pump includes an upper housing and a lower housing. A film is arranged between the upper housing and the low housing. An insulin storage chamber is formed between the film and the upper housing. Several conical holes are formed in the film. Large-diameter ends of the conical holes are adjacent to the insulin storage chamber. A piezoelectric ring is arranged on a side of the film facing away from the insulin storage chamber. The edges of two opposite sides of the film and the piezoelectric ring are connected with an external alternating current power supply through wires, respectively. A liquid outlet is formed in the lower housing.

Abstract: Exemplary embodiments provide methods, apparatuses, and supporting structures for deploying a flexible, slender element (such as a conduit or subcutaneous sensor) into a user's tissue (such as skin tissue). A first embodiment leverages rotary motion to deploy the element while constraining the element to prevent buckling. A second embodiment leverages linear motion to deploy the flexible, slender element with the assistance of an introducer element to provide support. Other embodiments provide support features; for instance, a sacrificial sleeve may impermanently hold or embrace the slender element to temporarily increase the structural stiffness of the slender element. Another support structure may provide for tensioning the user's tissue, such as by causing the skin to bulge in an area where deployment of a slender element is facilitated. The cannula or sensor itself may also be structured or configured to support deployment.

Abstract: A bioelectronic implantable device includes engineered cells and an electronically controlled stimulator that regulates a quantity and timing of therapeutic agent produced by the engineered cells.

Abstract: A fluid injector system includes at least one injector for pressurizing and delivering at least one fluid from at least one fluid reservoir, at least one fluid path section providing fluid communication between a bulk fluid reservoir and a syringe connected to the at least one injector, and at least one sensor arranged along the at least one fluid path section. The at least one sensor includes an emitter configured to emit light through the at least one fluid path section, and a detector configured to receive the light emitted through the at least one fluid path section and generate an electrical signal based on at least one property of the received light.

Abstract: A device for administering a medical liquid, in particular a syringe pump. The device includes a main part into which a hollow body containing the liquid to be administered is receivable. The device includes a drive for acting on the hollow body such that the liquid is conveyed. The drive includes a drive head projecting from the main part. The device also includes a damping element disposed on an outside of the drive head for absorbing external impact forces acting on the drive head.

Abstract: A device for subcutaneous delivery of a medicament includes a dispensing module with a base wall applied to skin of a patient, an elongated seat arranged inside the dispensing module, the elongated seat including a rest portion, a cartridge arranged in the elongated seat and including a container holding the medicament, an elongated opening formed on the base wall at the elongated seat to allow the insertion of the cartridge into the elongated seat, and retaining members that interact with the cartridge and lock the cartridge inside the elongated seat . The device has an initial configuration where the retaining members do not act on the cartridge and the cartridge rests on the rest portion and is movable in the elongated seat along a longitudinal direction, and a final configuration where the retaining members interact with the cartridge and lock the cartridge in a predetermined position.