Abstract: A system for delivering respiratory therapy to a patient includes a patient interface device for delivering pressurized gas to a patient, a connector system for connection to a source of pressurized gas and a conduit system fluidly connecting the connector system to the patient interface device. The connector system includes a plurality of closable ports that allow a plurality of different modes of respiratory therapy to be provided. The conduit system may include a first gas line, a second gas line and a third gas line. The second gas line and third gas line may be contained within the first gas line along at least part of their length.

Abstract: An air delivery conduit includes first and second conduit portions that cooperate to form the conduit, each conduit portion including an inner layer of a film laminate that forms an interior surface of the conduit and an outer layer of a textile that forms an exterior surface of the conduit.

Abstract: An exhaust arrangement for exhausting gases from a passage defined within a portion of a patient circuit used in providing a flow of a breathing gas to an airway of a patient, the exhaust arrangement comprising: a body defining a number of exhaust ports passing therethrough, each exhaust port having an inlet and an outlet and sized and configured to provide for the passage of gasses therethrough; and a raised portion positioned about the number of exhaust ports and extending from the body, wherein the raised portion is sized and configured to extend into the passage of the portion of the patient circuit from an inner surface of the portion of the patient circuit immediately adjacent the exhaust arrangement.

Abstract: An anesthesia machine is disclosed, which includes an anesthetic delivery apparatus, a respiratory loop, a first ventilation control apparatus, and a ventilation module. The anesthetic delivery apparatus mixes a first gas with an anesthetic to obtain a second gas, and delivers the second gas to the respiratory loop. The first ventilation control apparatus controls the respiratory loop to periodically deliver the second gas to a patient, thereby providing anesthesia and respiratory support for the patient. The ventilation module performs periodic respiratory support on the patient by using the first gas. Therefore, according to the requirements of the clinical scenario, the corresponding ventilation support can be performed on the patient by using the anesthesia machine, thereby improving the application range of the anesthesia machine without using additional devices.

Abstract: A wearable air treatment system includes a user interface configured to be coupled about at least a portion of a face of a user. The wearable air treatment system also includes an air treatment module coupled to the user interface. The air treatment module in turn includes an air inlet configured to receive ambient air therethrough. A light source is positioned distal of the air inlet and is configured to emit light to treat at least a portion of the received ambient air. The air treatment module also includes an air outlet positioned distal of the light source. The air outlet is configured to direct at least a portion of the treated ambient air towards an interior of the user interface.

Abstract: A humidification system comprises a first sensor and a second sensor. The first and second sensors are adapted to sense flow characteristics within the system. The first and second sensors are isolated from the flow by barriers formed by respective first and second sealing members. The sealing members extend through apertures formed in the system and have a portion that contacts the sensing elements of the respective first and second sensors. A cartridge can hold the sensors and provide repeatable penetration depths into a flow passage of the system. A medical tube has a composite structure made of two or more distinct components that are spirally wound to form an elongate tube. One component can be a spirally wound elongate hollow body; the other component can be an elongate structural component spirally wound between turns of the spirally wound hollow body.

Abstract: Disclosed is a vehicle-mounted aromatherapy device. An accommodating cavity is provided inside a main body; a first ventilation structure in communication with the accommodating cavity is provided at one end of the main body, and an air inlet in communication with the accommodating cavity is provided at the other end of the main body; a fragrance device is mounted inside the accommodating cavity of the main body; the fan blade is rotatably connected to the main body; and the fixing member is fixedly connected to the main body. When the vehicle-mounted aromatherapy device is in use, the air flow of an air outlet of an automobile air conditioner is used to accelerate the volatilization of a solid aromatherapy, the aromatherapy substance can be conveniently replaced, and the aromatherapy device can be used for many times.

Abstract: The aspects of the disclosed embodiments relates to methods for optimization of the sliding properties of urinary catheters. The urinary catheters are first treated with a non-equilibrium gaseous plasma sustained in reactive gases or a mixture of a reactive gas with a noble gas. The first treatment enables a hydrophilic surface finish when oxygen is a reactive gas and an almost super-hydrophilic finish when the catheter is treated with hydrogen plasma followed by oxygen plasma. The hydrophilicity of the surface finish obtained upon the first plasma treatment is beneficial for adhering a layer of water solution of chitosan, which spreads uniformly on the entire outer surface of the catheter. The catheter with a layer of water solution of chitosan is dried and then treated with plasma containing an oxidative gas for better absorption of water by the dried chitosan film.

Abstract: A system for delivering a fluid to a target site of a patient's vasculature having a catheter having a proximal end, a distal end, and a lumen defined by an interior surface of the catheter extending longitudinally through the catheter between the proximal end and the distal end, a guiding element having a distal end, a proximal end, and an exterior surface, the guiding element positioned in the lumen creating an area, between the exterior surface of the guiding element and the interior surface of the catheter, having an effective cross-sectional area sized fluid communication while the guiding element is in the lumen. Also, a method of performing a neurovascular procedure includes providing a multi-catheter assembly including an access catheter, a guide catheter, and a procedure catheter, coupling the assembly to a robotic drive system, and injecting contrast media into the assembly without removing a guiding element.

Abstract: Devices and systems and method for treating a patient are described herein that are used with or include at least one infusion catheter having a proximal end with a hub, a distal end with a distal tip, and a lumen extending from the proximal end to the distal tip. The devices include a connector body having a first connector for fluidly coupling and detachably connecting to the hub of the at least one infusion catheter, a second connector for fluidly coupling and detachably connecting to at least one manual syringe pump, and a passive pressure-controlled mechanical flow regulator that regulates fluid flow supplied by manual pump action of the least one manual syringe pump to the infusion catheter and delivered by the infusion catheter into the vascular system of the patient.

Abstract: A catheter includes an elongated tubular shaft having a distal end, a proximal end, and a lumen extending therethrough. The elongated tubular shaft includes a polymeric outer layer, a polymeric inner layer, and a braided middle layer. A marker band is positioned adjacent the distal end of the elongated tubular shaft and may surround the middle layer, and a polymeric distal tip is attached to the distal end of the elongated tubular shaft. A distal end of the outer layer terminates proximal to the marker band such that the middle layer includes an exposed region that is exposed from the outer layer between the distal end of the outer layer and a proximal end of the marker band, and the distal tip is formed over the exposed region of the middle layer and the marker band, and extends distally beyond the distal end of the elongated tubular shaft.

Abstract: A pain management system includes a medication dispenser located external to a patient. A subcutaneous port is placed internally to the patient and receives a quantity of medication. The port can be filled from a syringe or medication dispensing system. An echogenic catheter can be placed in proximity to a patient's nerve or nerve center using a point-of-care ultrasound imaging system. A pain management method includes the steps of placing a subcutaneous port using ultrasound imaging for guidance and administering pharmacologic agents via a catheter connected to the port. Alternative embodiment catheter systems include echogenic tips, a stylet, and multiple internal coil sections to facilitate accurate placement. Alternative embodiment pain management methods include the steps of utilizing such features for optimizing patient outcomes.

Abstract: A torquer releasably securing an elongated medical device thereto and including a torque limiting actuator limiting a torque applied to the torquer.

Abstract: A catheter including a catheter body (60) formed of a polymeric material and having a lumen therethrough, a metallic reinforcement structure in contact with the polymeric material, a core, and a sensor wire with a first portion (71) formed in a plurality of windings wrapped around the core and a second portion formed as a twisted pair (80) extending the catheter body (60). The catheter may include a pull wire anchored to the core.

Abstract: Disclosed herein are catheter assemblies for controlling a position of a prosthetic device. The catheter assemblies can include a gimbal assembly, a catheter, and a plurality of control elements. The can include an outer gimbal member and an inner gimbal member. The catheter is coupled to the gimbal assembly. The control elements extend distally through the catheter. Movement of the gimbal assembly changes tension on the plurality of control elements.

Abstract: Disclosed are intravascular devices for navigating tortuous vascular environments like the human brain. The disclosed guidewire includes a core wire, a first tube within which the distal section of the core is inserted, and a second tube within which the proximal section of the core is inserted. The first and second tubes have a substantially similar outer diameter such that the guidewire has a uniform outer diameter over its complete length for effective catheter tracking over the guidewire.

Abstract: Various aspects of the present disclosure may be directed toward apparatuses, systems, and methods that include a medical device including an elongate body having a proximal portion, a distal portion, and three mutually perpendicular planes. The medical device may include a first steering line and a second steering line and a first stiffening material and a second stiffening material. The first stiffening material and the second stiffening material may be configured to maintain planarity of deflection of at least the distal portion of the elongate body.

Abstract: A method of making magnetically controllable devices for interventional medical procedures comprises the steps of: manufacturing a medical device for interventional medical procedures having magnetic materials which are without permanent magnetization; and establishing permanent magnetization within the magnetic materials subsequent to manufacturing, wherein the permanent magnetization allows the medical device to be magnetically controllable. The method may further include the step of packaging and sterilizing the medical device, wherein establishing permanent magnetization occurs after packaging and sterilization. The establishing permanent magnetization within the magnetic materials may include providing different magnetic orientations to distinct portions of the magnetic materials. The magnetic material includes one of a platinum alloy or a palladium alloy.

Abstract: A securement device holds a medical article having flexible portions in position upon the body of a patient and inhibits movement of the medical article. The medical article may be insertable into the securement device from above from below or along a longitudinal axis of the device. The securement device may have abutment surfaces which interact with the flexible portions of the medical article to further inhibit rotation of the device. A securement kit can include a securement device and a catheter.

Abstract: A ureteral catheter includes a drainage lumen including a proximal portion configured to be positioned in at least a portion of a patient's urethra and/or bladder and a distal portion configured to be positioned in a patient's kidney, renal pelvis, and/or in the ureter adjacent to the renal pelvis, the distal portion including a retention portion for maintaining positioning of the distal portion of the drainage lumen, the retention portion including two or more openings on a sidewall of the retention portion for permitting fluid flow into the drainage lumen, wherein a number of the openings nearer to a distal end of the retention portion is greater than a number of the opening(s) nearer to a proximal end of the retention portion.

Abstract: Vascular access system embodiments can be configured to remove gas and a piercing member from a catheter assembly. In some embodiments, vascular access systems can remove gas and at least a portion of a piercing member concurrently or simultaneously. In some embodiments, vascular access systems can remove gas before removing at least a portion of a piercing member. In several embodiments, a vascular access system can include a first barrel configured to remove gas and a second barrel configured to retract a piercing member.

Abstract: Provided herein is a cannula tip protector assembly for a Luer type syringe having a Luer connector with a syringe needle having a first diameter, and a needle tip having a second diameter smaller than the first diameter, the needle tip is attached in fluid communication to the syringe needle at an end of the syringe needle opposite the Luer connector, a protection sleeve slidably positioned over the syringe needle and needle tip, and a cannula tip protector actuator unit having a Luer connector attachment part and a protection sleeve connector, the cannula tip protector actuator unit arranged to move the protection sleeve from a first position in which the needle tip is covered by the protection sleeve to a second position in which the needle tip is exposed outside the protection sleeve.

Abstract: A method for accessing a blood vessel using a catheter insertion device. The catheter insertion device includes a housing, a needle, a catheter, a guidewire, and a thumbwheel. The thumbwheel is rotatably fastened at a front end of the housing and accessible through an opening in the housing. The guidewire is coupled to the thumbwheel such that an axis of rotation of the thumbwheel is perpendicular to the guidewire and rotation of the thumbwheel advances the guidewire through the lumen of the needle. The method includes preparing the catheter insertion device, inserting a tip of the needle and distal end of the catheter into a blood vessel, advancing the guidewire out of the lumen of the needle into the blood vessel by holding the housing and rotating the thumbwheel, furthering the distal end of the catheter over the guidewire, and removing the needle and the guidewire from the catheter.

Abstract: The invention relates to a device for supplying and/or draining substances in a minimally irritating, tissue-compatible manner that is preferably adapted to the movements of the body and its organs, the device comprising a balloon, which can be placed in an interior space of the body and filled from outside the body, which balloon (optionally together with a supplying and/or draining tube or shaft segment that carries the balloon) surrounds a fillable compartment, to which a tube or shaft-like segment is attached which connects the interior space to the body surface; wherein the balloon is produced by blow moulding from a tube blank made of a multilayer film-like material; wherein the tube blank is extruded in multiple layers: wherein, in addition to at least one elastically deformable layer of polyurethane (PUR), at least one non-elastically deformable, odour- and/or media-tight barrier layer of ethylene vinyl alcohol copolymer (EVOH) or of polyvinylidene chloride (PVCD) or of polyamide (PA) or of a thermopl

Abstract: Devices, systems, and methods are disclosed that help deliver catheters or other treatment devices to locations within a patient's body. The system includes at least the treatment device, at least an outer sheath, and at least a catheter located inside the outer sheath, said outer sheath comprising a proximal end and a distal end, said catheter comprising a proximal portion and a distal portion, the treatment device positioned at the distal portion of the catheter, at least one orienting balloon positioned on the catheter distal to the treatment device, the at least one orienting balloon upon inflation protruding at least partially outside the distal end of the outer sheath.

Abstract: The disclosed technology includes a fluid evacuation device for a balloon catheter including at least one spine having a curved proximal portion and a straight distal portion extending along a longitudinal axis, a first coupler coupled to the curved proximal portion of the spine to constrain at least one spine to move along the longitudinal axis, and a second coupler attached to the distal portion of the at least one spine so that in a first operational mode, the curved proximal portion of the at least one spine is expanded to a first outer profile and in a second operational mode, the curved proximal portion of the at least one spine is compressed to a smaller outer profile than the first outer profile such that the at least one spine moves the second coupler along the longitudinal axis.

Abstract: A method of manufacturing a therapeutic device includes forming a container wall that is sized to contain multiple cells capable of producing a therapeutic agent within an interior region of the container wall. The method further includes exposing the container wall to a solvent to remove material from the container wall to define first pores along an interior portion of the container wall and second pores along an exterior portion of the container wall. The first pores have a first average size that (i) allows passage of the therapeutic agent through the first pores and (ii) prevents passage of immune cells through the first pores. The second pores have a second average size that is larger than the first average size, and the second pores are sized to promote vascularization along the exterior portion.

Abstract: The invention concerns a self-anchoring microneedle based delivery system which is operable to quickly and easily deploy microneedles into a tissue substrate such as the eye, for the purposes of targeted drug delivery and includes a body having a first section and a second section displaceable relative to one another, first hollow microneedles provided on the first section and second hollow microneedles provided on the second section, the first and second sections being displaceable relative to one another in order to transition the microneedles between a disengaged state and an engaged state.

Abstract: A microneedle patch according to one embodiment of the present disclosure includes: a base including an invasive part and a non-invasive part; and a microneedle located in the invasive part of the base, wherein at least a portion of the microneedle is loaded with drug, and no microneedle is located in the non-invasive part.

Abstract: An allergen-loadable microneedle cartridge is disclosed. The cartridge includes at least one substrate, a plurality of microneedles in a microneedle layout protruding from at least one substrate, and fillable allergen sites corresponding to the microneedle layout. The fillable allergen sites and microneedle layout are configured such that the microneedles can penetrate subject skin and deliver pharmacologically active doses of allergens in a minimally invasive process. A planar allergen filling system for loading the allergen-loadable microneedle cartridges is also disclosed. The system has a loading section with spaced-apart allergen loading sites that correspond to the microneedle layout of the microneedle cartridge. Filling wells having allergen deposition areas larger than the allergen loading sites transfer deposited allergen to the allergen loading sites through capillary channels.

Abstract: A hemostasis valve assembly includes a housing, hemostasis valve, through-member, actuator, and pin. The through-member is slidable along a first direction between a first position that closes a hemostasis valve, and a second position that opens the valve. The actuator can displace the through-member distally along the first direction by sliding along a second direction transverse to the first direction. A motion restricting groove on the through-member includes a closed position portion in which the pin is disposed when the through-member is in the first position; a first top portion in which the pin is disposed when the through-member reaches a position distal of the second position; an open holding portion in which the pin is disposed when the through-member is in the second position; and a second top portion in which the pin is disposed when the through-member reaches a position distal of the second position.

Abstract: Devices, systems, and methods for sealing medical devices, particularly during intravascular access, are disclosed herein. Some aspects relate to a hemostatic valve for sealing a wide range of medical devices, such as catheters, wires, embolectomy systems. The valve can include an elongate member having a first end, a second end, and a central lumen extending therebetween. A reinforcement structure extends along at least a portion of the elongate member and is coupled to the elongate member. A shell defining a first aperture and a second aperture may be included, which first and second apertures can be fluidly coupled by the elongate member. A tensioning mechanism is coupled to the shell and to the elongate member, the tensioning mechanism can be moveable between a first configuration wherein the tensioning mechanism is collapsed and the central lumen is sealed and a second configuration wherein the central lumen is open.

Abstract: A coupler including a first connector having a first end, a second end opposite the first end, and a first valve disposed between the first end and the second end. The first valve having a compressed state and an expanded state. The coupler includes a second connector having a housing, a connecting portion extending from the housing, and a second valve disposed at least partially within the housing, the second valve having a compressed state and an expanded state. The coupler further includes a collar coupled to the housing of the second connector and configured to receive at least a portion of the first connector to detachably couple the first connector to the collar and the second connector such that the housing of the second connector is at least partially disposed within the first connector.

Abstract: A simply lockable quick coupling for releasably connecting a hose to an implantable apparatus, comprises a first attachment piece that can be connected to the hose and a second attachment piece that can be connected to the apparatus, wherein the attachment pieces can be rotated relative to each other in the locked state.

Abstract: A disinfection cap is described for connection to a medical connector, the disinfection cap includes a housing having a top wall and sidewall forming a cavity, disinfectant or antimicrobial agent and a ball disposed within the cavity. An outer surface of the housing includes a thread sufficient to interlock with a mating feature of a threaded connector, or more specifically a male luer connector. The cap may also include a peelable seal to prevent the disinfectant or the antimicrobial agent from exiting the cavity. The cavity of the cap may also include one or more ribs disposed on the inner surface of the cavity to retain the ball in the cavity, forming a flow channel as the ball is depressed further into the cavity. An exterior sidewall surface of the housing may include a plurality of grip members.

Abstract: A medical fluid container tubing assembly includes a medical fluid container, a luer connector including a luer port, a tube extending from the medical fluid container and terminating at the luer connector, and a cap fitted onto the luer connector. The cap includes a port sized to provide an interference fit with the luer port of the luer connector. The cap further includes a hydrophobic filter positioned and arranged to allow air to aseptically enter the tube to equalize pressure inside and outside of the tube. The cap may include an inner port including an inner surface tapered for forming an interference fit with an outer surface of a male luer port of a luer connector, an outer shroud sized to fit around an outer shroud of the luer connector, a lumen extending from the port to an opening, and a hydrophobic filter covering an opening formed by the lumen.

Abstract: A system for treating atrial dysfunction, including heart failure and/or atrial fibrillation, that includes one or more pressurizing elements and control circuitry. The one or more pressurizing elements can comprise one or more balloons and can be configured to be positioned in the left atrium, and optionally the pulmonary artery, of a patient's heart. The one or more pressurizing elements can be coupled to one or more positioning structures that can be configured to position the one or more pressurizing elements in the left atrium, and optionally the pulmonary artery. The control circuitry can be configured to operate the one or more pressurizing elements to decrease or increase pressure and/or volume in the left atrium, and optionally the pulmonary artery, in accordance with different phases of the cardiac cycle.

Abstract: A total artificial heart system includes at least one artificial ventricle coupled to (or capable of being coupled to) a chamber or a vessel of a human heart and at least one drive system coupled to the artificial ventricle. The drive system contains at least one implanted in a chest cavity electric motor. The drive system causes the artificial ventricle to contract and/or expand in a specific fashion dependent on a value inversely proportional to a rotational speed of a rotorcam and/or a height of the cam follower of the heart system.

Abstract: Circulatory support systems and related methods are disclosed in which a ventricular assist device is controlled based on cardiac activity monitored via cardiogram electrodes. A circulatory support system includes a ventricular assist device, cardiogram electrodes, and a controller. The controller processes a cardiogram signal generated via the cardiogram electrodes to determine one or more physiological parameters indicative of an activity level and/or cardiac cycle timing, determines at least one operating parameter for the ventricular assist device based on the one or more physiological parameters, and controls operation of the ventricular assist device in accordance with the at least one operating parameter.

Abstract: The invention relates to a clamping element for securing a tube, having the following: a first guide and a second guide for receiving a tube, wherein the two guides run towards each other, and the clamping element is designed in such a manner that it is connectable to a pump device such that a tube guide can be formed by the two guides at a pump inlet and pump outlet.

Abstract: Systems and methods for delivering pharmaceutical compositions to the nasal cavity using iontophoresis. The systems and methods include a delivery system that is disposed in operative apposition with a tissue surface, which delivery system can circulate iontophoretic solution having ions of a therapeutic substance in the nasal cavity. The circulation can be continuous or periodic. The circulation can replace the iontophoretic solution within the nasal cavity over a period of time, such as from 15 seconds to 1 minute. The systems and methods further include an electrode device that is utilized to apply current to perform the iontophoresis while the circulating of the iontophoretic solution in the nasal cavity. In some embodiments, the therapeutic substance is a steroid, and in further embodiments, the ions are betamethasone ions.

Abstract: A multimodal cranial nerve stimulation treatment system for personalized optimal rehabilitation, includes a measurement unit that measures a brain activity signal transmitted from a brain of a subject; an electrical stimulation unit that controls a brain activity of the subject by applying electrical stimulation to the brain of the subject; a haptic stimulation unit that controls the brain activity of the subject by inducing a haptic stimulation motion of the subject based on a content to be provided to the subject from a content providing unit; a detection unit that detects a brain activity region of interest requiring rehabilitation treatment by comparing the brain activity signal measured by the measurement unit with a preset reference brain activity signal; and a control unit that controls at least one of the electrical stimulation unit, the content providing unit, and the haptic stimulation unit.

Abstract: The paths that alternating electric fields take through a body part can be controlled by providing at least eight electrically isolated signal generators, each of which is configured to apply electrical signals between a respective electrode element on one side of the target region and a respective electrode element on the opposite side of the target region. This replaces the prior art's single wide-cross-section electric field with eight independently controllable electric fields, each of which has a relatively narrow cross-section. Using these relatively narrow cross-section fields, either alone or in combination, can improve aiming of the electric field, which can in turn increase the field strength in the target region. Optionally, activation of these relatively narrow cross-section fields can be shifted in time to achieve steering of the overall electric field.

Abstract: The present disclosure relates to neuromuscular stimulation and sensing cuffs. The neuromuscular stimulation cuff has at least two fingers and a plurality of electrodes disposed on each finger. More generally, the neuromuscular stimulation cuff includes an outer, reusable component and an inner, disposable component. One or more electrodes are housed within the reusable component. The neuromuscular stimulation cuff may be produced by providing an insulating substrate layer, forming a conductive circuit on the substrate layer to form a conductive circuit layer, adhering a cover layer onto the conductive circuit layer to form a flexible circuit, and cutting at least one flexible finger from the flexible circuit. The neuromuscular stimulation cuff employs a flexible multi-electrode design which allows for reanimation of complex muscle movements in a patient, including individual finger movement.

Abstract: A neurostimulator for applying electrical stimulation through a subjects skin includes a wearable configured to be worn by the subject and a control unit connected to the wearable. Electrodes are mounted on the wearable and electrically connected to the control unit. An interface pad overlies the electrodes and is configured to be positioned on the subjects skin. The interface pad is configured to conduct electrical signals between the electrodes and the subjects skin. The interface pad includes a body of elastomeric material supporting a conductive material. The interface pad is mounted on the wearable so that the interface pad covers the electrodes and distributes electrical current uniformly across the electrodes.

Abstract: The present disclosure relates to a tip for a high-frequency skin treatment apparatus irradiating uniform radio frequency (RF), the tip being coupled to a handpiece to radiate a radio frequency (RF) signal to a human body in a non-invasive way, and comprising: a housing; a contact portion coupled to the housing and comprising a plurality of contact pins that come into close contact with skin of the human body to irradiate the skin with the RF signal; and a driver configured to drive the contact portion so that the contract portion radiates the RF signal according to a control signal transferred from the handpiece. Each of the contact pins comprises: a fixed frame; a moving frame; and an elastic body. The elastic body connects an upper inner surface of the fixed frame to an upper inner surface of the moving frame.

Abstract: An electrical stimulation device includes a control circuit, a power supply circuit, and an electrical stimulation circuit. The power supply circuit provides a first power supply signal. The electrical stimulation circuit is controlled by the control circuit to generate an electrical stimulation signal according to the first power supply signal. The electrical stimulation signal includes two burst signals. A burst duty cycle of the first burst signal ranges from 0.0005% to 50%. A burst frequency of the first burst signal ranges from 0.1 Hz to 200 Hz. The burst signals are monophasic burst signals with opposite polarities or both are biphasic burst signals. Pulse frequencies of pulses in the monophasic burst signals and the biphasic burst signals range from 1000 Hz to 10 million Hz. Pulse duty cycles of the pulses in the monophasic burst signals and the biphasic burst signals range from 0.01% to 50%.

Abstract: Devices, systems and methods provide forms of asymptomatic diaphragmatic stimulation (ADS) therapy that affect pressures within the intrathoracic cavity, including: 1) dual-pulse ADS therapy, during which a first ADS pulse is delivered during a diastolic phase of a cardiac cycle and a second ADS pulse is delivered during a systolic phase, 2) paired-pulse ADS therapy, during which a first ADS pulse is delivered, closely followed by a second ADS pulse, with the second ADS pulse functioning to extend or enhance a phase of a transient, partial contraction of the diaphragm, and 3) multiple-pulse ADS therapy, during which a stream of ADS pulses is delivered, wherein the time between pulses is based on heart rate. Devices, systems and methods also monitor electromyography (EMG) activity of the diaphragm relative to baseline activity to assess the health of a diaphragm subject to ADS therapy and to adjust ADS therapy parameters or sensing parameters.

Abstract: A kit for treating lung disease includes at least one lead having at least one contact, and a pulse generator configured to connect to the least one lead. The pulse generator is programmed to generate electrical signals for transmission through the at least one lead and for release by the at least one contact in a predetermined location of an epidural space to mitigate lung disease symptoms.

Abstract: A sarcopenia diagnostic system of present invention comprises, an electrical stimulation and measurement unit configured to apply multi-frequency electrical stimulation to the body and measure a multi-frequency impulse response signal m-FIRS to the multi-frequency electrical stimulation, a response signal analysis unit configured to remove noise and distortion from the multi-frequency impulse response signal m-FIRS to obtain an involuntary muscle contraction signal, and configured to extract a feature vector in each of time domain and frequency domain from the involuntary muscle contraction signal, and an artificial intelligence model learning unit receiving the extracted feature vector as input, and generates a classification for muscle strength and muscular endurance from the feature vector through artificial intelligence-based model learning to diagnose sarcopenia, wherein the multi-frequency impact response signal m-FIRS is provided in units of a plurality of segments divided by frequency.