Abstract: The disclosure relates to a vision device for detecting eye movement, which comprises a screen for displaying stimuli, an LCD panel for selectively blocking the viewing by either eye of the stimuli displayed on the screen, the panel being capable of adopting a number of configurations, including a configuration blocking the vision of either eye and a configuration allowing the vision of either eye, and at least one camera for tracking eye movement in wavelengths outside the visible spectrum through the panel. The camera being capable of tracking the movement of the eyes under the effect of the stimuli in the configurations of the panel that allow vision and block vision.

Abstract: An eye measurement system includes an optical system. The eye measurement system is disposed in a housing which includes an aperture for providing light to and from the optical system and a subject's eye while the subject is separated and spaced apart from the housing, and the eye is not maintained in a fixed positional relationship with respect to the housing. An optical system movement arrangement moves the optical system. An automatic eye tracking arrangement ascertains a current positional relationship of the eye with respect to the optical system without human assistance, and in response thereto controls the optical system movement arrangement to move the optical system into a predetermined positional relationship with respect to the eye, for measurement of the eye, without human assistance. The eye measurement system can make objective, and/or subjective, refraction measurements of the eye.

Abstract: A processor acquires a fundus image, generates a choroidal vascular image from the fundus image, and detects a watershed of a choroidal vascular network in the choroidal vascular image.

Abstract: An ophthalmic instrument for measuring optical quality of an eye is provided, including: a multi-element eyepiece and a rotatable mirror. A mirror surface of the rotatable mirror is optically conjugated with a first focal plane in an object space of the multi-element eyepiece through a first lens, to adjust an angle of light entering the eye. A focal point of the first lens is arranged in a virtual focal plane of the multi-element eyepiece. The multi-element eyepiece includes an eyepiece, a field lens and a second lens arranged in sequence. The field lens includes a third lens, a fourth lens and a fifth lens arranged in sequence. The eyepiece, the third lens, the fourth lens and the fifth lens each is a positive lens, and the second lens is a negative lens.

Abstract: An information processing system is disclosed that can be rather easily introduced and can detect biological information in a preferred manner are provided. The information processing system includes: a holding device including a holding unit configured to hold a portable information processing terminal, and a communication unit configured to communicate with the portable information processing terminal, the portable information processing terminal including a first detector configured to detect biological information; and a control unit configured to perform control for acquiring the biological information. In a case where the portable information processing terminal is held by the holding unit, and communication between the portable information processing terminal and the holding device has been established via the communication unit, the control unit is configured to acquire the biological information detected by the first detector.

Abstract: According to some embodiments, a device for tissue evaluation comprises a sensor housing, the sensor housing comprising a sensor head and a sensor body, where the sensor head is configured to engage with target tissue for evaluation, and a sensing element disposed within the sensor housing and configured to measure a force or reaction force of the target tissue as the device is pressed against the target tissue.

Abstract: Embodiments of this application provide a PPG control method and apparatus, and an electronic device. The method is applied to an electronic device, the electronic device includes a PPG module, and the PPG module includes a light emitting module. The method includes: determining a current measurement environment and/or measurement target, where the measurement environment includes motion, rest, and sleep, and the measurement target includes a heart rate and blood oxygen; and determining a light emitting mode of the light emitting module based on the current measurement environment and/or measurement target. The method according to this embodiment of this application can reduce power consumption of the PPG module while ensuring measurement accuracy of the PPG module.

Abstract: Provided is a portable scalp sensing device including a camera module, wherein the camera module includes a camera part including an image sensor and a lens, a light diffusion member disposed on an optical axis of the camera part, a blue-cut filter disposed between the camera part and the light diffusion member to block light of a predetermined wavelength that is incident on the camera part, a UV light source, and a white light source, the light diffusion member may guide light diffused from each of the white light source and the UV light source to illuminate a measurement target region with the light, and the camera part may obtain an image of the measurement target region illuminated by the light.

Abstract: A diabetic visual assessment system is provided which utilizes an elongate reconfigurable neck having a proximal terminal end and a distal terminal end and comprising a gooseneck segment. The gooseneck segment utilizes a plurality of gooseneck sections with each gooseneck section being separated by an articulation joint. The gooseneck segment further utilizes a first inflection joint of a plurality of inflection joints disposed between the proximal terminal end and the distal terminal end. The diabetic visual assessment system further utilizes camera coupling system having a cylindrical shaft disposed within a proximal region thereof. The camera coupling system is disposed at the distal terminal end of the elongate reconfigurable neck and the cylindrical shaft is coupled to the distal terminal end of the elongate reconfigurable neck.

Abstract: A system for imaging teeth and identifying a status of said teeth comprises: a transillumination device (100) including a light source configured to transilluminate a tooth and a digital camera configured to capture one or more images of the transilluminated tooth; a smart device (200); and a remote server including a machine learning algorithm configured to identify a status of the tooth based on one or more images of the tooth captured by the transillumination device. The transillumination device is arranged to send captured images of the tooth to the smart device and the smart device is configured to select and send one or more of the captured images to the remote server.

Abstract: An intraoral scanner comprises a housing, a light source for generating light, an optics system for focusing the light, a detector for detecting returning light reflected off an intraoral object, and a focus shifting mechanism configured to shift a focal plane of the optics system. The optics system is configured such that, after having passed through the optics system, an outermost chief ray of the light with respect to an optical axis of the optics system is divergent to the optical axis and an outermost marginal ray of the light with respect to the optical axis is parallel or divergent to the optical axis.

Abstract: A wearable stretchable and/or flexible imaging device conforms to a shape of a patient surface to which it is attached. The device includes a stretchable and/or flexible encapsulation substrate and superstrate. The substrate is configured to be removably attachable to a patient surface. A stretchable and/or flexible imaging array layer is disposed between the substrate and superstrate and includes at least one ultrasound transducer for receiving ultrasound waves and at least one laser diode for generating pulses of light that cause ultrasonic emission from tissue within a patient. A stretchable and/or flexible electrical interconnect layered structure is disposed between the superstrate and substrate and is operatively coupled to the ultrasound transducer and the laser diode such that the stretchable and/or flexible electrical interconnect layered structure is configured to selectively address the at least one ultrasound transducer and the at least one laser diode.

Abstract: An electronic device for estimating human body microclimate temperature is provided. The electronic device may include: a main body; a first temperature sensor configured to measure a first temperature and a second temperature sensor configured to measure a second temperature, the first and second temperature sensors being disposed at different positions in the main body; and a processor, which while the main body is worn on a body part of a user or is carried by the user, is configured to estimate human body microclimate temperature of the user based on a difference between the first temperature and the second temperature.

Abstract: Temperature sensors and/or optical sensors can be used to determine whether an electronic device is worn or not worn by a user of the electronic device (e.g., on-wrist or off-wrist). In some examples, the temperature sensors can serve as a complement or a replacement to optical sensors when determining on-wrist or off-wrist. In some examples, detecting, via temperature sensors, a temperature difference between opposite sides of the wearable device (e.g., front face and back face) indicates on-wrist.

Abstract: Provided is a non-contact blood vessel analyzing method that enables speedy and detailed contactless analysis of states of blood vessels. This non-contact blood vessel analyzing method uses a non-contact blood vessel analyzing device 1 that includes a light irradiator 2 that casts light on a skin surface site including a blood vessel region, an image acquirer 3 that acquires an image 3im that is a moving image or a series of still images of the skin surface site, and an image processor 4 that derives at least a first waveform that indicates temporal change of a brightness value in a first wavelength domain and a second waveform that indicates temporal change of a brightness value in a second wavelength domain, in a certain region in the image 3im. A frequency, a phase, or an amplitude, of the first waveform and the second waveform, is derived.

Abstract: The invention provides a body-worn monitor that measures a patient's vital signs (e.g. blood pressure, SpO2, heart rate, respiratory rate, and temperature) while simultaneously characterizing their activity state (e.g. resting, walking, convulsing, falling). The body-worn monitor processes this information to minimize corruption of the vital signs by motion-related artifacts. A software framework generates alarms/alerts based on threshold values that are either preset or determined in real time. The framework additionally includes a series of ‘heuristic’ rules that take the patient's activity state and motion into account, and process the vital signs accordingly. These rules, for example, indicate that a walking patient is likely breathing and has a regular heart rate, even if their motion-corrupted vital signs suggest otherwise.

Abstract: A system integrating a hemodynamic parameter (Hdp) monitoring system and a radiofrequency generator synchronized by a processing system is disclosed. The system is capable of identifying health condition-specific Hdp variation value changes in a patient upon the exposure of low-energy amplitude modulated electromagnetic fields frequencies (SFq). The exposure of SFq influences cellular functions or malfunctions in a warm-blooded mammalian subject. The construction of a library of SFq can be used to efficiently and effectively diagnose and treat a health condition in a patient. Methods of using the system are further disclosed.

Abstract: An apparatus comprising a housing, a detection system, and a transmission system. The detection system is disposed within the housing. The detection system is configured to measure a blood pressure of a patient. The transmission system is disposed within the housing. The transmission system is operatively coupled to the detection system and is configured to transmit a signal indicative of a blood pressure of the patient.

Abstract: An electronic device and a method for controlling the electronic device are provided. The electronic device includes a motion sensor and optical sensors. Each of the optical sensors includes a light emitter and a light receiver. The optical sensors are separately driven to determine a respective signal characteristic of each of the optical sensors. A current state of an object to be measured is determined, based on at least one signal received through the motion sensor or the optical sensors. A light emitter of at least one of the optical sensors is driven, based on the respective signal characteristics of the optical sensors according to the current state of the object to be measured. Based on the respective signal characteristics of the optical sensors, a light signal sensed through a light receiver of at least one of the optical sensors is selected and received.

Abstract: A heart rate detection method and an electronic device are provided. The method includes: acquiring a first PPG signal with a first preset duration; determining a plurality of heart rate values based on the first PPG signal; determining a difference of every two adjacent heart rates based on the plurality of heart rate values, the difference of every two adjacent heart rates being used for generating a heart rate difference trajectory graph; acquiring a parameter of a heart rate difference trajectory based on the heart rate difference trajectory graph, the parameter of the heart rate difference trajectory including one or more of the following parameters: an angle, a quantity, an angle standard deviation, and a distance standard deviation; determining a heart rhythm type of the first PPG signal according to the parameter of the heart rate difference trajectory; and displaying the heart rhythm type of the first PPG signal.

Abstract: A system for screening and management of hypertension, which includes a high precision fingertip photoplethysmography (PPG) acquisition device and the application software of hypertension screening and management in a portable device such as a smartphone. The former includes 905 nm wavelength infrared light emitting sensor, photoelectric receiving device, and Bluetooth transmission module. The latter includes PPG signal configuration and acquisition module, automatic hypertension classification and screening module and hypertension management module. The system can process the real-time PPG signal and can classify and evaluate the blood pressure level and carry on the long-term management and the hypertension health instruction.

Abstract: A biometric information measurement device includes: a layered film including a plurality of layered layers including two or more types of layers having different refractive indices; and a light receiving element configured to receive light transmitted through the layered film and generate a signal corresponding to the light.

Abstract: The present disclosure relates to noninvasive methods, devices, and systems for measuring various blood constituents or analytes, such as glucose. In an embodiment, a light source comprises LEDs and super-luminescent LEDs. The light source emits light at at least wavelengths of about 1610 nm, about 1640 nm, and about 1665 nm. In an embodiment, the detector comprises a plurality of photodetectors arranged in a special geometry comprising one of a substantially linear substantially equal spaced geometry, a substantially linear substantially non-equal spaced geometry, and a substantially grid geometry.

Abstract: The present disclosure provides systems and methods for determining a mean transit time of blood within a blood vessel using pressure measurements collected by an intravascular tool and not dependent on temperature measurements. The intravascular instrument may collect a plurality of pressure measurements distal to an area of interest within the blood vessel as a bolus passes through the blood vessel and over the instrument. The plurality of pressure measurements may be plotted on a pressure dilution curve. A function of the pressure dilution curve and time is used to determine the mean transit time of the blood within the blood vessel.

Abstract: The present invention describes a method and system for non-invasive management and monitoring of intracranial pressure and a device for measuring of a skull volumetric variation. Specifically, the present invention comprises detecting and receiving the analog signal of the skull volumetric variation of a user, processing its signal and transmitting the processed signal to a pre-configured receiver. The present invention is situated in the technical fields of medicine, biomedicine, neuro science, measuring of physical quantity and electrical engineering.

Abstract: The invention relates to a calibration system for automatically setting an intended operational filling of an esophageal catheter with balloon probe, which can be inserted into the esophagus, for determining an esophageal pressure, in particular for a ventilation device, comprising a device for filling the balloon probe with a measuring fluid after placing the balloon probe in the esophagus, a pressure sensor for detecting the esophageal pressure prevailing in the balloon probe, and a calibration controller which is designed such that it incrementally changes the amount of measuring fluid in the balloon probe, the calibration controller recording an esophageal pressure detected by the pressure sensor for each amount of measuring fluid in the balloon probe set incrementally as a measuring point in this way and assigning said esophageal pressure to the respective set amount of measuring fluid in the balloon probe.

Abstract: The present disclosure relates to a magnetic particle imaging device having a field of view (FOV) wide enough to be applicable to the human body. A magnetic particle imaging device according to some embodiments includes at least: an FFP generation unit generating a field free point (FFP) in a FOV; first to third operation coil units moving the FFP in first to third directions which are vertical to each other, respectively; an excitation coil unit generating a magnetic field in the FOV, and exciting a magnetic particle in the FOV; a reception coil unit receiving a magnetic signal generated from the magnetic particle; and a processor dividing the FOV into a plurality of partial FOVs, controlling the first to third operation coil units so that the FFP moves in each partial FOV, and generating an image for the FOV based on the magnetic signal for each partial FOV.

Abstract: A method for performing a scan of a subject utilizing a magnetic resonance imaging (MRI) system includes triggering a prescan by an MRI scanner of the MRI system upon the subject being setup on a table of the MRI scanner and the table reaching an iso-center of the MRI scanner. The method includes subsequent to the prescan, triggering a calibration scan of the subject with the MRI scanner, wherein the calibration scan is an acoustic noise suppressed MRI scan. The method includes obtaining calibration data from the calibration scan. The method includes obtaining prescription parameters for subsequent scans of the subject with the MRI scanner from the calibration data. The method includes triggering at least one scan of the subject with the MRI scanner based on the prescription parameters.

Abstract: The present disclosure provides systems and methods for magnetic resonance imaging using a radio frequency coil, such as, for example, an intracranial radio frequency coil. In at least one aspect, a system can include a surgical tool and a magnetic resonance imaging system. The surgical tool can include a distal end portion and a radio frequency reception coil attached to the distal end portion. The magnetic resonance imaging system can be configured to project a magnetic field within a field of view and intraoperatively image the radio frequency reception coil in the field of view.

Abstract: A control module for use in a magnetic resonance imaging (MRI) guided biopsy procedure using an MRI coil includes a body and a plurality of MRI compatibility features. The body includes one or more ports configured to couple the control module to a biopsy device. The body further includes a display configured to output one or more biopsy device status indicators. The MRI compatibility features are configured to reduce an electromagnetic footprint of the control module.

Abstract: Embodiments of the present invention disclose a magnetic resonance system and a magnetic resonance scanning control method, the method including: acquiring a three-dimensional body model of a scan subject; on the basis of the three-dimensional body model, estimating a value of a first body parameter and a value of a second body parameter of the scan subject; and determining a specific absorption rate on the basis of a site to be scanned of the scan subject, the value of the first body parameter and the value of the second body parameter.

Abstract: An electrode location determiner for an electro-anatomical mapping system utilizing a distal assembly. The determiner includes a center of mass calculator, a tilt angle calculator and an electrode position updater. The center of mass calculator calculates a center of mass of the distal assembly from active current locations (ACL) locations of electrodes of the distal assembly. The tilt angle calculator receives output from a sensor having a sensor longitudinal axis aligned along a shaft longitudinal axis of a shaft to which the distal assembly is attached, checks whether or not the shaft longitudinal axis extends through the center of mass and, if not, calculates a tilt angle of the center of mass from the longitudinal axis and a line extending from a position of the sensor and the center of mass. The electrode position updater corrects the ACL locations according to the tilt angle.

Abstract: Medical apparatus includes a probe including a distal part adapted for insertion into a body of a living subject and first and second magnetic transducers in the distal part of the probe. Control circuitry drives the first magnetic transducer to generate a first AC magnetic field at a first frequency and drives a magnetic field generator in proximity to the body to generate a second AC magnetic field within the body at a second frequency, calculates a disposition of the distal part of the probe by processing a first signal output by the second magnetic transducer at the first frequency, and calculates position coordinates of the distal part of the probe by processing a component of a second signal output by one of the first and second magnetic transducers at the second frequency while canceling from the second signal interference at the first frequency.

Abstract: The disclosed technology includes a medical probe comprising a substantially cylindrical structure including a proximal circular base, a distal circular base substantially parallel to the proximal circular base, and plurality of spines extending along a longitudinal axis between the proximal circular base and the distal circular base, and a membrane positioned over the plurality of spines defining an internal volume about the longitudinal axis. The plurality of spines comprise a bifurcated portion positioned along at least a portion of the spine between the distal circular base and the proximal circular base. The membrane comprises one or more electrodes coupled to an external surface of the membrane. The membrane is configured to permit fluid communication from outside the membrane to the internal volume.

Abstract: A method and system for determining an extent of matter removed from a targeted anatomical structure are disclosed. The method includes acquiring an initial representation of a targeted anatomical structure and then removing matter from the targeted anatomical structure. An instrument is then navigated within the targeted anatomical structure. The instrument includes a tracking array, and a relative position of the instrument within the targeted anatomical structure is determined by the tracking array. The method includes recording the relative position of the instrument within the targeted anatomical structure to determine a final representation of the targeted anatomical structure. Finally, the method includes determining an extent of matter removed from the targeted anatomical structure by comparing the initial representation of the targeted anatomical structure with the final representation of the targeted anatomical structure.

Abstract: A system including an instrument having an elongate body, and a control system communicatively coupled to the instrument. The control system is configured to access a branched skeleton model defining a skeleton including a plurality of segments representing respective segments of a luminal network, identify a segment of the plurality of segments of the branched skeleton model corresponding to a position of a distal end of the instrument, determine a depth along the segment corresponding to the position of the distal end of the instrument, and determine a position of the distal end of the instrument relative to an anatomical map of the luminal network based on the identified segment and the depth along the segment.

Abstract: A registration method whereby a sensor-based approach is used to establish initial registration and whereby upon the commencement of navigating an endoscope, image-based registration methods are used in order to more accurately maintain the registration between the endoscope location and previously-acquired images. A six-degree-of-freedom location sensor is placed on the probe in order to reduce the number of previously-acquired images that must be compared to a real-time image obtained from the endoscope.

Abstract: A device for treating an aneurysm of a human or mammal patient, wherein the aneurysm may self-expand. The device comprising an implantable member adapted to be placed in around an outside of a blood vessel having the aneurysm to enable the implantable member to exercise a pressure on the outside of the blood vessel having the aneurysm. The device further comprising a measuring device or sensor for measuring or sensing an expansion of the aneurysm and a monitoring system adapted to monitor the expansion of the aneurysm based on a signal received from the measuring device or sensor.

Abstract: A computing device is provided for providing triggering times to a medical scanning apparatus adapted to perform triggered imaging data acquisition. Said computing device includes an input data interface configured to obtain real-time data of respiratory cycles of a patient; a computation module configured to implement an artificial intelligence entity, which is trained and adapted to generate a prediction of a number of respiratory cycles of the patient based on the obtained real-time data; a triggering module configured to determine triggering times corresponding to the predicted respiratory cycles; and an output data interface configured to output the determined triggering times to the medical scanning apparatus.

Abstract: A method of cough detection in a headset, the method comprising: receiving a first signal from an external transducer of the headset; receiving a second signal from an in-ear transducer of the headset; and detecting a cough of a user of the headset based on the first and second signals.

Abstract: A facial recognition system and a physiological information generative method are disclosed. The facial recognition system includes a visible light sensor, a thermal imaging sensor, and a processor. The generative method is executed by the processor, using a real-time object detection algorithm. The generative method includes receiving one or more current visible and thermal images, and identifying the nasal area in the current thermal images when a face region in the current visible images is not identifiable by the real-time object detection algorithm in the processor; determining in the processor that respiratory information is abnormal according to the cycles of exhalation and inhalation, as detected through brightness changes in the nostril area; and notifying abnormal respiratory information.

Abstract: According to an aspect, there is provided an apparatus for predicting a ballistic force on a subject, the apparatus comprising: a memory comprising instruction data representing a set of instructions; and a processor configured to communicate with the memory and to execute the set of instructions, wherein the set of instructions, when executed by the processor, cause the processor to: model the body of the subject as a mechanical system comprising a plurality of masses joined by springs and dampers, wherein each of the masses represents a different region of the body of the subject, and predict the ballistic force on the subject, based on oscillations of the mechanical system.

Abstract: Disclosed is a system, method and/or computer readable medium for use with for imaging the heart and/or segments of the chambers of the heart. Segments from a heart pair (i.e., an ES model and an ED model of the heart) are preferably matched between segments that make up the respective surfaces of the ES and ED models, each segment having a relative angle and displacement. The same segment is present in the two models but at a different position and orientation in three-dimensional space. The displacement of the matching or paired segments indicates the movement of that segment over the heart cycle. In a preferred embodiment, the segments are positioned in the same anatomical structure of the heart, therefore tracking the segments represents the actual anatomic movement. A four-dimensional model may preferably be created from two-dimensional echocardiogram images.

Abstract: The described technology generally relates to wearable devices, smart apparel, systems and methods for movement wellbeing, and performance through haptic feedback. One or more wearable devices (e.g., standalone or incorporated into apparel, accessories, or other wearable items) may promote neuromuscular feedback for joint centration often referred as joint stability. Joint centration or joint stability combines the functioning cartilage, ligaments, fascia, tendons, and muscles that allow joints to stay secure as forces transfer through them during movement with minimal stress on the passive soft structures. In some embodiments, there may be an electronic control unit with at least one sensor to detect user's joint movement, such as movement on a three-axis position or joint speed, and acceleration. Depending on the movement of the users, the electronic control may communicate joint movement to a user and provide cues for joint stability, joint movement range, muscle memory, and body position awareness.

Abstract: Disclosed is a computer-implemented method of analyzing the setup of an array of acceleration sensors on an anatomical body part of a patient encompasses acquisition of acceleration data using a cranial headset having acceleration sensors and determining an appropriate contact of the acceleration sensor to the patient's head, detecting, marking, filtering out, or removing different kinds of noise as well as acceleration signals which are considered to be due to gross patient movement. This is done to determine whether the setup of the headset on the patient's head is good enough to generate measurement signals of acceptable quality. If this is the case, the headset is subsequently used to acquire continuous datasets of acceleration data which is then evaluated to determine the patient's physiological status.

Abstract: Examples of head-mounted devices for postural alignment correction are provided. In one aspect, a head-mounted device is implemented to include a display, a plurality of sensors including an inertial measurement unit, and a controller. The controller includes instructions executable to control the head-mounted device to receive inertial measurement data from the inertial measurement unit, to input the received inertial measurements into a machine learning model, and to receive an estimated body posture from the neural machine learning model. In this aspect, additionally or alternatively, the machine learning model is an artificial neural network that has been trained to estimate the body posture by calculating a craniovertebral angle, where the craniovertebral angle is defined as an angle between a first line crossing a tragus point and a cervical vertebra point and a second line crossing the cervical vertebra point.

Abstract: A system, a wearable device, and a method are provided which can increase the accuracy of physiological metrics while detecting if the patient ingested digital medicine and/or improve performance of the wearable device. The wearable device can comprise machine executable instructions that when executed by the processor, cause the processor to perform various algorithms, such as, for example, at least one of a step count algorithm, a body angle algorithm, a heart rate algorithm, a peak finder algorithm, an adaptive thresholding algorithm, a heart rate variability algorithm, a R-R cleaning Algorithm, a deltaR-R cleaning algorithm, a merge twin interval algorithm, a split tall intervals algorithm, an absorb short intervals algorithm, a bimodal detection algorithm, and a resting algorithm.

Abstract: A wearable device is illustrated. The wearable device has a body, at least one light emitting unit, at least one light sensing unit and an action recognition module. The wearable device is suitable for wearing on a wrist of a user. The light emitting unit is disposed on an inner side of the body, and the light emitting unit emits a light beam illuminating at least a portion of the wrist. The light sensing unit operatively senses the light beam reflected by the at least portion of the wrist and generates a light sensing signal. The action recognition module is configured to operatively determine a function that corresponds to an action of the user.

Abstract: Provided herein is a sepsis monitoring device including: a patch having a first side and an opposing second side, where the second side is adapted to adhere to human skin; a plurality of microneedles arranged on the second side of the patch and configured to penetrate the human skin to a depth sufficient to collect interstitial fluid when the patch is adhered to the human skin, where the plurality of microneedles are configured to collect the interstitial fluid when the patch is adhered to the human skin; and a sensor in fluid communication with the plurality of microneedles and configured to detect a biomarker indicating a sepsis condition or an onset of the sepsis condition when contacted with the interstitial fluid collected by the plurality of microneedles.

Abstract: The present disclosure relates to a continuous blood glucose measurement device configured to prevent, in a state where a body attachment unit is inserted in and attached to a human body, an incision portion made by a guide needle from being formed to surround at least a part of a sensing area formed at a sensing member, whereby an incision portion is not formed around the sensing area so as to prevent the incision portion from causing a drop in a blood glucose measurement value and thus enable detection of an accurate blood glucose measurement value from the early stage of operation. Further, the guide needle has a shape not surrounding at least a part of the sensing area, so as to prevent, even without an additional device, the guide needle from forming an incision portion around the sensing area in a human body and thus enhance, by a simple structure, the accuracy of blood glucose measurement.