Abstract: Disclosed are Self-Gelling materials and structures or materials or structures having one or more self-gelling components that overcome existing gel limitations due to hydrogel localization for medical applications by providing, for example, 1) microstructurally, or physically, anchored characteristics to help localize the gel, and the overall printed, or otherwise formed structure, giving structural form to the gel that allows the gel to be localized within the body, and even sutured in place, and mitigates gel migration and extends its residence time; 2) to provide an underlying 3D printed structure to help contain and support the gel after implantation; and more. Self-Gelling 3D printed structures may be further processed via milling to yield deconstructed scaffold micro-granules, with the composition and nano-/micro-structure of the original larger structure.

Abstract: A crystallized bioabsorbable polymer scaffold comprises a polymer composition of poly (L-lactide-co-tri-methylene-carbonate) or poly (D-lactide-co-tri-methylene-carbonate) or poly (L-lactide-co-?-caprolactone) or poly (D-lactide-co-?-caprolactone) in the form of block copolymers of blocky copolymers, wherein the scaffold is cold-bendable. A crystallized bioabsorbable polymer scaffold comprising a polymer composition of poly (L-lactide-co-tri-methylene-carbonate) or poly (D-lactide-co-tri-methylene-carbonate) or poly (L-lactide-co-?-caprolactone) or poly (D-lactide-co-?-caprolactone) in the form of block copolymers of blocky copolymers, wherein the scaffold crystallizes in response to orthogonal strain.

Abstract: Drug eluting stents, methods of making, using, and verifying long-term stability of the drug eluting stents, and methods for predicting long term stent efficacy and patient safety after implantation of a drug eluting stent are disclosured. In one embodiment, a drug eluting stent may include a stent framework; a drug-containing layer; a drug embedded in the drug-containing layer; and a biocompatible base layer disposed over the stent framework and supporting the drug-containing layer. The drug-containing layer may have an uneven coating thickness. In addition or in alternative, the drug-containing layer may be configured to significantly dissolve/dissipate, disappear between 45 days and 60 days after stent implantation. Stents may reduce, minimize, or eliminate patient risks associated with the implantation of a stent, including, for example, restenosis, thrombosis, and or MACE.

Abstract: Various aspects of the present invention provide compositions and implantable devices including a water-insoluble therapeutic agent solubilized in a matrix of a gallate-containing compound. Other aspects provide methods of manufacturing and using such compositions and devices.

Abstract: A packaging tray for use in a blood processing system including a blood processing device having device components arranged on a component surface and a removable fluid flow circuit having circuit components configured to interact with corresponding device components, wherein the packaging tray configured to be selectively arranged on and removable from the component surface. The packaging tray includes a first surface and a second surface opposite to the first surface and spaced apart by a thickness, component sections arranged at positions corresponding to positions of respective device components, the component sections respectively formed, at least partially, as openings extending through the thickness, and a plurality of recessed pathways formed on the first surface, the recessed pathways extending between the component sections. A blood processing device may include the packaging tray, and a blood processing system may include a blood processing device and the packaging tray.

Abstract: A blood purification apparatus includes a first light-applying unit, a second light-applying unit, a third light-applying unit, a light-receiving unit, and an error-absorbing unit configured to acquire oxygen saturation from a ratio between a first received-light intensity and a second received-light intensity and to absorb any error in the oxygen saturation with reference to a third received-light intensity detected by the light-receiving unit. The error in the oxygen saturation occurs with a change in the blood concentration (hematocrit value).

Abstract: In draining liquid in an AV-coupling-type blood circuit, it is determined that the blood circuit is in an AV-coupled state. A blood purification apparatus can switch between an open state in which fluid can flow through a blood removal side circuit and a blood return side circuit and a closed state in which the fluid cannot flow therethrough. The apparatus generates a difference in pressure between the blood removal side circuit and the blood return side circuit by rotating a blood pump in the case of the closed state. The apparatus then determines whether the blood circuit is the closed circuit by switching to the open state and monitoring the difference in pressure from detecting pressure inside the blood circuit. The apparatus drains liquid remaining in the blood circuit to a predetermined drainage destination with the blood circuit forming the closed circuit.

Abstract: A blood purification apparatus that drains a residual liquid in a circuit. The blood purification apparatus includes: a sealed blood circuit including a blood removal side circuit and a blood return side circuit connected to each other; a drainage circuit that is connected to the blood circuit and drains a residual liquid in the blood circuit; an air introducer that is connected to the blood circuit and introduces air into the blood circuit; and a liquid delivery pump that is provided to at least one of the blood circuit and the drainage circuit and, by rotating, delivers the residual liquid to the drainage circuit from the blood circuit with the introduced air as a medium for pushing out the residual liquid.

Abstract: Provided is a blood collection container capable of suppressing contamination of plasma by white blood cells and components in white blood cells. A blood collection container according to the present invention includes a blood collection container main body, a plasma separation material stored in the blood collection container main body, and an aqueous solution stored in the blood collection container main body, in which a solute contained in the aqueous solution contains an anticoagulant, and a total concentration of the solute in the aqueous solution is 100 mM or more and 450 mM or less, or 1200 mM or more.

Abstract: A laparoscopic flexible suction/irrigation device of the present invention encases a inner rigid cannula with an outer flexible cannula. Upon translating the distal end of outer flexible cannula beyond the distal end of the inner rigid cannula, the outer flexible cannula returns to a preexisting curvilinear shape. This curved extension can thereafter be positioned via a proximal handle to concavities within the surgical site for precise and effective fluid retraction.

Abstract: Described herein are syringe caps including a plug portion and a protruding member extending from one end of the plug portion. The protruding member can extend a length greater than a depth of an accumulated component in the syringe.

Abstract: A powered fluid injector including an assembly for retaining a pressure jacket and a syringe on a fluid injector is provided. The assembly includes a base plate comprising a body; a first retaining arm and a second retaining arm operatively mounted on the body of the base plate, wherein the first retaining arm have a first retaining surface and the second retaining arm having a second retaining surface. The first retaining surface and the second retaining surface abut a distal surface of at least one of the pressure jacket and the syringe. The assembly also includes a linkage assembly connected to at least one of the first retaining arm and/or the second retaining arm to move the retaining arms between at least a first open position and a closed position.

Abstract: The present disclosure is directed to a cap to be worn by an individual having a scalp intravenous tube so as to help in maintaining the body temperature of the individual. The cap includes a body, at least one opening and a fastener. The body has a plurality of panels. The at least one opening is formed between the plurality of panels of the body. The fastener is positioned on a portion of at least one of the plurality of panels of the body to connect the plurality of panels of the body so as to attach the body of the cap to a head of an individual.

Abstract: An insulin monitoring system includes one or more processors, one or more computer-readable storage devices, and program instructions stored on at least one of the one or more storage devices for execution by at least one of the one or more processors. The program instructions include: first program instructions to track, in real time, the amount of insulin active in a patient; second program instructions to calculate the amount of insulin need of the patient by tracking the patient's metabolic states; third program instructions to compare the insulin active in the patient with the insulin need of the patient; and fourth program instructions to determine an insulin fault level based on the comparison.

Abstract: A system and method can provide for a remote electronic device to be used to remotely initiate delivery of a medicament bolus with a medical device, such as an insulin pump, with the medical device providing audible or tactile confirmation of the programmed bolus. The bolus amount can be calculated by or programmed or otherwise entered into the smartphone, etc., and then transmitted to the medical device. When the pump receives the transmitted bolus amount, it issues one or more indications such as audible sounds and/or vibrations in any number of desired combinations. For instance, each individual sound or vibration may correspond to an increment of the medicament. The user can therefore determine the size of the medicament bolus by the number of sounds or vibrations and can confirm or cancel delivery of the bolus.

Abstract: A medical device includes one or more processors and memory including instructions that, when executed by the one or more processors, cause the medical device to monitor, using one or more sensors, a geofence parameter of the medical device; determine a change in a location setting of the medical device based on the geofence parameter; automatically switch, responsive to the changed location setting, an operation mode of the medical device from a first mode currently programmed for care of a patient to a second mode, the second mode using different parameters than the first mode to control the medical device; and restrict access to an element of the medical device in the second mode that is accessible in the first mode. An infusion pump and methods of using a medical device are also provided.

Abstract: A fluid delivery device comprises a drive unit including an actuator and one or more first features and a cartridge filled with a fluid prior to being inserted into the housing. The cartridge having a fluid reservoir sealed at one end by a movable piston and sealed at another end by a pierceable septum. The cartridge includes one or more second features that are configured to align and mate with the one or more first features allowing the cartridge to be inserted into the drive unit. The piston is moveabe by the actuator once the cartridge is inserted into the drive unit.

Abstract: Methods and systems for infusing a user. An infusion pump includes a housing with an elastic component configured to expand and store potential energy. The infusion pump includes a first tube fluidically coupled to an outlet of the housing. The first tube is configured to conduct the fluid from the housing at a first flow rate. The infusion pump includes an air filter fluidically coupled to a distal end of the first tube via an air filter inlet. The infusion pump includes a second tube fluidically coupled to the air filter via an air filter outlet. The second tube is configured to adjust the first flow rate of the fluid conducted from the housing to a second flow rate. The infusion pump further includes one or more components for distributing the fluid to a user, the one or more components fluidically coupled to an outlet of the second tube.

Abstract: Provided is a pushing device for a drug delivery device that is implanted in the body and coupled to a drug delivery device, which includes a press button for discharging a drug stored inside a housing to the outside, to selectively press the press button, the pushing device including: a body portion detachably coupled to the drug delivery device with skin tissue placed therebetween; and a presser supported to be movable from the body portion in a longitudinal direction thereof and disposed to face the press button.

Abstract: Systems and methods disclosed herein relate to a disease management device which includes at least one or more medication bladders, configured to store fluid and a medication delivery pump, configured to deliver a fluid from one or more medication bladders to a patient. Each medication bladder has at least a rigid portion and a flexible portion, the flexible portion coupled to the rigid portion to create an at least partially sealed enclosure. The rigid portion includes structures, such as channels, configured to facilitate emptying the medication bladder through an output port. On application of pressure from the pump, the flexible portion is configured to generate a pressure against the structures rigid portion, which facilitates emptying of fluid from the medication bladder through the output port.

Abstract: Rapidly administered emergency drug therapy represents life-saving treatment for a range of acute conditions including hypoglycemia, anaphylaxis, and cardiac arrest. A miniaturized (e.g., <3 cm3), lightweight (e.g., <2 g), minimally invasive fully wireless, emergency rescue device for the storage and active burst-release of indefinitely stable particulate forms of peptide and hormone drugs into subcutaneous sites for direct reconstitution in interstitial biofluids is disclosed. The device demonstrates a fast (e.g., <5 minutes) therapeutic effect. The device may deliver a drug across fibrotic tissue, which commonly accumulates following in vivo implantation, thereby accelerating systemic delivery. Fully wireless delivery of dry particulate glucagon in vivo is demonstrated, providing emergency hypoglycemic rescue in diabetic mice. Additionally, triggered delivery of epinephrine is demonstrated in vivo.

Abstract: The present invention relates to a manual insertion aid for inserting a cannula unit into a cannula holder. The manual insertion aid comprises a handle and two jaws projecting from the handle and forming a receiving opening that is configured for engaging with a cannula unit. In order to provide a simple and lightweight insertion aid, the minimum clearance between the two jaws is greater than or equal to 1.5 mm and smaller than or equal to 7 mm, and wherein the maximum projecting length of each of the two jaws from the handle is greater than or equal to 4 mm and smaller than or equal to 18 mm.

Abstract: A pump set for use with a pumping apparatus includes tubing for carrying a liquid. A valve mechanism is mounted to the tubing between an inlet section and a pump engagement section. The valve mechanism includes a first port connected to the inlet section of the tubing, a second port connected to the pump engagement section of the tubing, and a valve disposed between the first and second ports. The valve includes a stem rotatably mounted within a stem holder. The stem includes a flow passage extending through the stem and having an open V shape whereby a narrow open end of the flow passage communicates with the first port and a wide open end of the flow passage communicates with the second port to place the inlet section of the tubing in communication with the pump engagement section of the tubing.

Abstract: An automated, closed-loop gravity infusion system including a fluid source, a drop counter operatively engaged with a drip chamber of the fluid source, a roller clamp functionally linked with the drop counter, a processor operably engaged with the roller clamp, and a human-machine interface (HMI) functionally linked with the processor. Patient data is accessed by the HMI. The system utilizes the patient data and data from the drop counter to determine an appropriate roller clamp position. The drop counter continuously monitors the drip chamber's drip rate and feeds the data to the processor which then analyzes the data and automatically adjusts the roller clamp's position to provide an appropriate fluid dosage to the patient. The HMI is functionally linked to a remote centralized computing system configured to simultaneously monitor several identical systems, each of which is being used to infuse a different patient.

Abstract: A method of operating a system having a fluid pump mechanism and a related controller involves: operating the system in a first mode to automatically deliver the medication in accordance with a therapy control algorithm; and receiving stress-identifying data generated at least in part from gesture data for the user. The gesture data is provided by a gesture-based physical behavior detection system. The method determines, from the stress-identifying data, that the user is under stress while the medication delivery system is operating in the first mode. In response to detecting stress, the system is operated in a second mode to automatically deliver the medication to the user in accordance with a stress-correlated therapy control algorithm. The second mode compensates for user stress as determined from the stress-identifying data.

Abstract: A medication injector assembly allowing for bubble removal without loss of liquid medicine includes a tubular body fitted containing a cartridge proximate to its first end, to which a needle is selectively attachable so that the needle is in fluidic communication with the cartridge. A plunger and an actuator, which are operationally engaged, are positioned in the tubular body. The actuator is positioned to selectively motivate a stopper of the plunger incrementally through the cartridge to dispense a dose of a liquid medicine from the cartridge through the needle. A valve is positioned in a sidewall of the tubular body proximate to its second end. A tube extends from the valve through the stopper so that the valve is in fluidic communication with the cartridge. Air that is adjacent to the stopper passes through the tube to remove the air from the liquid medicine.

Abstract: A medicament delivery device (1) comprising: a housing (3), an actuator structure (5) arranged in the housing (3) and configured to be moved linearly from an initial position relative to the housing (3) to a final position, the actuator structure (5) having a medicament container holder (5c) configured to receive a mechanically flexible medicament container (13a), the actuator structure (5) comprising a movable button (5a) arranged in a default position protruding from the housing (3) when the actuator structure (5) is in the initial position, wherein the button (5a) is configured to be moved from the default position into the medicament container holder (5c) to a squeeze position to squeeze the medicament container (13a), wherein the actuator structure (5) has a first engagement structure (5d) and the housing (3) has a second engagement structure (3e) configured to engage with the first engagement structure (5d) when the button (5a) is in the default position, to prevent the actuator structure (5) from movem

Abstract: A separation syringe assembly comprising: a syringe barrel assembly and a plunger assembly configured to travel relative to the syringe barrel, the syringe barrel assembly having a distal end and a proximal end with a longitudinal axis extending therebetween, the syringe barrel assembly having an outer wall in the form of a hollow cylinder, an inner wall in the form of a hollow cylinder capable of being axially translated and arranged concentrically within the outer wall, a drain actuator provided secured to the proximal end of the inner wall, and a cap provided at the distal end of the syringe barrel assembly; the plunger assembly having a proximal end and a distal end and aligned with the longitudinal axis, the plunger assembly providing a first plunger and a second plunger, the first plunger is a generally cylindrical hollow barrel having an entrance port near the distal end of the first plunger and enclosed on the proximal end, the second plunger provides a cylindrical body with an open distal end and con

Abstract: A syringe for injecting a fluid into a patient is provided. A syringe tip defining a substantially frusto-conical interior void extends from an end wall of the syringe. A hub is configured so that the hub can be selectively and securedly attached to the syringe. A frusto-conical member of the hub matingly engages the frusto-conical void of the syringe tip when the hub is secured to the syringe, forming a fluid-tight seal.

Abstract: A drug delivery device, in the form of an injector, may include one of a number of systems for limiting the delivery of a medical fluid or drug product in case of movement of (e.g., removal of) the injector relative to the patient as determined by a proximity sensor. The drug delivery system may in the alternative or in addition include systems for indicating the amount of medical fluid or drug product delivered (or not delivered) in case of movement of (e.g., removal of) the injector relative to the patient as determined by the proximity sensor. The injector may be, for example, an on-body injector or an hand-held autoinjector.

Abstract: A medication delivery device usable with a medication container wherein advancement of a piston within the container expels medication. The device includes a housing and a drive assembly. The drive assembly includes a drive ribbon having distal and proximal edge sections. The drive ribbon has a retracted configuration defining a spiral and an extended configuration defining a helix. The drive ribbon is movable from the retracted configuration to the extended configuration with such movement defining a drive axis and advancing the piston. In some embodiments, the drive ribbon may not rotate as it is advanced while in other embodiments, the ribbon does rotate. The disclosed drive assemblies include manually driven assemblies, spring driven assemblies and motor driven assemblies. The containers may be replaceable to allow for reuse of the device. In some embodiments, replaceable cartridges which includes both a medication container and a drive ribbon are employed.

Abstract: A stopper is configured to be disposed within a medical cartridge includes a shell defining a cavity and an exterior surface sized and shaped to fit inside the medical cartridge and an insert configured to be inserted into the cavity, where the insert includes an electronic device having a sensor configured to generate a sensing signal. The shell is configured to be advanced into the medical cartridge by a plunger to apply pressure to a substance contained in the medical cartridge and the shell is configured to pass the sensing signal therethrough. The sensor is configured to be responsive to the position of the stopper in the medical cartridge.

Abstract: An autoinjector having a housing, a product container axially fixed in the housing, a torsion spring, a drive element, a propulsion member, and a needle protection sleeve which, when the autoinjector is pressed against a point of injection, carries out an actuation movement in the proximal direction. The autoinjector includes a display for signaling the progression or persistence of a discharge, with a display element, which is driven by the drive element, rotates about the longitudinal axis and has an optical contrast pattern, and a transparent window at the proximal end of the autoinjector, through which the rotating contrast pattern is visible. The window is completely circumferential by 360° about the longitudinal axis, i.e., is not interrupted by a frame or web parallel to the longitudinal axis, which otherwise creates a dead angle for the view on the display element.

Abstract: The present disclosure relates to an injector device having a housing, a cartridge with a reservoir for medicament, a needle unit with a needle, and a needle sleeve rotatably mounted to the housing about an axis. Prior to use of the injector device the needle is sealed from the reservoir, and at least one of the needle unit and the cartridge is axially slidably mounted to the housing. The needle sleeve includes an engagement member arranged to engage the needle unit and/or the cartridge. The engagement member is adapted such that rotation of the needle sleeve moves the needle unit and/or the cartridge in an axial direction to move the needle into fluid communication with the reservoir.

Abstract: A syringe that includes an adapter section and a barrel having a chamber that holds a fluid. The adapter section includes outer and inner walls that form a first groove. The inner wall includes barrel threads and the outer wall includes a first projection. A cap having cap threads engages the barrel threads to removably attach the cap to the adapter section. A locking element having a sidewall that includes a second projection is received in the first groove and removably attached to the cap by an interference fit. Rotation of the cap causes upward movement of the cap that overcomes the interference fit thereby removing the cap. The locking element is prevented from being removed from the first groove due to contact between the first and second projections. Presence of the locking element in the first groove after the cap is removed provides evidence of tampering.

Abstract: A medical treatment system including a treatment chamber, a source of an aqueous mist containing a medication, a source of an oxygen-enriched gas, and a control system adapted to alternately surround a human body part with a mist containing a medication and the oxygen enriched gas, which can be used to treat various skin disorders including infected lesions, bacterial infections such as acne (i.e. Propionibacterium acnes), fungal infections such as Athlete's foot (i.e. fungal genus Trichophyton), conditions associated with hair loss including alopecia as well as ulcerations and frostbite resulting from poor circulation. A method of treating skin disorders is also disclosed, that includes providing a mist containing a medication and enriched oxygen gas to the site being treated as well as providing oxygen to the patient during treatment.

Abstract: A temperature control method of a vaporizer that is provided with a heater to heat and vaporize an inflowing chemical liquid, includes determining an input power to the heater at a current time, based on an inflow rate of the chemical liquid into the vaporizer at each time in a first prediction interval from a current time to a first predetermined future time, a measured temperature of the vaporizer at the current time, and a predicted temperature of the vaporizer at each time in the first prediction interval.

Abstract: A system, method and device for integrating the application of acoustic resonance, as correlated with a wearer of the device, with the application of a continuous positive airway pressure system. The aspects disclosed herein are directed to improving CPAP compliance and efficacy. In various embodiments, the acoustic resonance may be applied directly to a wearer's paranasal sinus, or to an air passageway that communicates with an orifice of a person.

Abstract: The systems, devices, and methods described herein relate to providing breathing gas at a high velocity to a patient using a base unit and an auxiliary unit configured to be removably disposed on or at least partially in the base unit. The base unit has several couplings for improved control and sensing of the auxiliary unit and its components, wherein the couplings are configured to be non-contact with the corresponding components of the auxiliary unit and/or otherwise configured to minimize operational defects or improve efficiency. Non-contact couplings include induction heating, capacitive level sensing, a magnetically coupled rotor pump. RFID tag and reader, and Hall effect sensing. The breathing gas can be provided at high velocities by setting breathing gas flowrates based on dimensions of a nasal cannula used to direct the breathing gas into a patient's nares.

Abstract: A portable hyperbaric oxygen (PHBO) hood system includes a main hood, a neck sleeve configured to be disposed below the main hood, a pump system configured to control a pressure in the main hood to create hyperbaric environment in the PHBO hood system, and an intelligent controller. The pump system includes a pump and a flow line configured to supply oxygen to the main hood via the pump. The intelligent controller is configured to receive an oxygen saturation value of a patient, receive an oxygen concentration value of the flow line, determine a target pressure of the main hood based on the oxygen saturation value and the oxygen concentration value, and control the pump system to change the pressure of the main hood to the target pressure.

Abstract: A diffuser element for use over a vent opening of a breathing assistance apparatus. In some configurations, the diffuser element is formed by knitting or weaving one or more threads together into an interlocking pattern. In some configurations, the diffuser pad has a first surface and an opposing second surface and at least the first surface includes a surface texture. Arrangements for coupling the diffuser element to a structure that defines or carries the vent are also disclosed.

Abstract: A universal respiratory detector for detecting a respiratory gas. The universal respiratory detector may include a plurality of layers with a visual indicator to quickly and reversibly change color to detect a respiratory gas parameter such as carbon dioxide. The color change may be visible from both sides of the detector. In some examples, the respiratory detector may be a biocompatible and conformable sticker for mounting on a person's face or an oxygen delivery device.

Abstract: Apparatus for generating a supply of air at positive pressure for the amelioration or treatment of a respiratory disorder comprising a housing, a blower structured and configured to produce a flow of air at positive pressure, a flexible connector electrically and physically connected to the blower; and a blower rotation limitation structure configured to reduce rotation of the blower during use. The apparatus may comprise first and second blower suspensions for holding opposite ends of the blower. The blower suspension(s) may be flexible and in tension. The apparatus may comprise one or more connector anchors for anchoring a longitudinal middle section of the flexible connector to another part of the apparatus.

Abstract: A handpiece tip for refrigerant injection of an RF high frequency device for skin treatment including a refrigerant injection nozzle configured to inject a refrigerant for local anesthesia in a plane direction is provided. Also provided is a handpiece tip for refrigerant injection of an RF high frequency device configured such that a needle is inserted into a projecting piece of the skin, which is projected as the result of being suctioned by a skin adsorption contact unit, whereby the needle is located in a place at a position desired by an operator.

Abstract: An electronic device includes a controller that acquires, in a first period, a plurality of first period data that is biological signal data of a user; generates a first corrected data group by executing predetermined filter processing on the acquired plurality of first period data; generates a standard deviation data group by executing predetermined statistical processing on the plurality of first period data; derives a threshold based on the first corrected data group and the standard deviation data group that are generated; and determines a sleep state of the user, based on the threshold and second period data acquired in a second period different from the first period.

Abstract: A smart bed with a mattress that detects the one or more physical inputs, identifies at least one function corresponding to each physical input, and responds to each physical input by executing the at least one function. The physical input may be provided as a tap, pat, slap, stomp, or kick on a surface of the mattress. One or more sensors of the mattress may detect each physical input. A processor of the smart bed may identify and execute the at least one function associated with the at least one physical input. In addition, the processor may identify an individual who provided the physical input(s) and execute the corresponding function(s) in a manner tailored to the individual who provided the physical input(s). Methods of using such a smart bed are also disclosed.

Abstract: The signal processing device includes: a beat sound frequency determination unit that determines an optimal beat sound frequency of a user on the basis of a brain wave signal of the user; and a binaural beat signal generation unit that acquires an ambient environment sound, converts a sample acoustic signal prepared in advance into a binaural beat, on the basis of an optimal beat sound frequency, and mixes the binaural-beat-converted sample acoustic signal with the ambient environment sound, to generate a binaural-beat-converted ambient environmental sound signal.

Abstract: Methods of making sleeved hydrophilic urinary catheters (10).

Abstract: A vascular prosthesis deployment device and related methods are disclosed. In some embodiments the deployment device may include a delivery catheter assembly. The delivery catheter assembly may include an outer sheath, an intermediate sheath, and an inner sheath. One or more of the outer sheath, the intermediate sheath, and the inner sheath may be reinforced with a braided structure to prevent elongation and ovalization of the sheaths. The braided structure may include one or more yarn members imbedded in a material and formed from a plurality of twisted singles. The twisted singles may be formed from an aromatic polyamide material.

Abstract: A flexible catheter includes an elongated body, a first monolithic wire, and a second monolithic wire. The first monolithic wire forms a first sensor that is disposed in the distal end portion of the elongated body. The first sensor is configured to detect the position of a distal end of the elongated body within anatomy of a patient. The second monolithic wire forms a second sensor that is disposed in the distal end portion of the elongated body a known distance from the first sensor. The first and second sensors are configured to determine the position of the distal end portion within six degrees-of-freedom. A method of manufacturing the flexible catheter is also provided.