Abstract: A composite material for use, for example, as an orthopedic implant, that includes a porous reinforced composite scaffold that includes a polymer, reinforcement particles distributed throughout the polymer, and a substantially continuously interconnected plurality of pores that are distributed throughout the polymer, each of the pores in the plurality of pores defined by voids interconnected by struts, each pore void having a size within a range from about 10 to 500 nm. The porous reinforced composite scaffold has a scaffold volume that includes a material volume defined by the polymer and the reinforcement particles, and a pore volume defined by the plurality of pores. The reinforcement particles are both embedded within the polymer and exposed on the struts within the pore voids. The polymer may be a polyaryletherketone polymer and the reinforcement particles may be anisometric calcium phosphate particles.

Abstract: A spinal interbody device includes a base link comprising a first end and a second end, the base link including a cutout extending through the base link between the first end and the second end; a linkage including a first link having a first end coupled to the first end of the base link and a second end, the first link including a first aperture extending through the first link and defining a first longitudinal axis; and a second link having a first end coupled to the second end of the first link and a second end coupled to the second end of the base link, the second link including a second aperture extending through the second link and defining a second longitudinal axis. The base link and the first and second links define top and bottom surfaces configured to engage adjacent portions of bone, and first and second sides extending between the top and bottom surfaces.

Abstract: A system for performing interbody fusion surgery including an expandable intervertebral spacer and specialized instruments for choosing the correct size of implant, implanting the device within the intervertebral space, and for delivery of bone graft or bone substitute to the interior of the implant.

Abstract: A spinal implant comprises a first member, a second member and an actuator defining a transverse pivot axis. A first link is connected to the first member and the actuator adjacent the pivot axis. The first link includes an inner surface defining a cavity. A second link is connected to the second member and the actuator adjacent the pivot axis. The actuator is rotatable for translating the pivot axis such that the second link is movable within the cavity to move the members between a contracted configuration and an expanded configuration. Systems and methods of use are disclosed.

Abstract: The present disclosure relates to kits for bone graft delivery, and specifically, for near-simultaneous and integrated delivery of bone graft material during the placement of surgical cages or other medical implants in a patient's spine. The kits include integrated fusion cage and graft delivery devices that deliver and disperse biologic material through a fusion cage to a disc space and, that may, without withdrawal from the surgical site, allow for selectively detaching the fusion cage for deposit to the same disc space. The integrated fusion cage and graft delivery device is formed such that a hollow tube and plunger selectively and controllably place bone graft material and a fusion cage in or adjacent to the bone graft receiving area. The kits also include a cover plate that secures to the fusion cage.

Abstract: A surgical driver apparatus includes a housing and an inner driver shaft having a proximal end secured within the housing and a distal end extending out from a first side of the housing. The inner driver shaft is configured to rotate with respect to the housing. The surgical driver apparatus further includes an outer driver shaft and an idler driver shaft. The outer driver shaft is positioned coaxial with the inner driver shaft and configured to rotate independently from the inner driver shaft. The idler driver shaft is configured to transmit torque to the outer driver shaft. Additionally, the surgical driver apparatus includes a driver key comprising a driving feature and a counter-driving feature. The driver key is configured to engage a second side of the housing in one of a plurality of orientations configured to rotate the inner driver shaft and/or the outer driver shaft.

Abstract: Delivery systems for expandable and stented implants include adjustable tensioning members that control the expansion of the implant along the length of the implant. The tensioning members are wound onto one or more rotors located on the distal segment of the delivery system, which are rotated to unwind the tensioning members and incrementally expand the implant. Positioning mechanisms are also provided to adjust the position and orientation of the implant during delivery.

Abstract: A stent graft delivery system including a stent graft cover, a screw gear, and a handle assembly. The handle assembly includes an external slider, a T-tube, and a Y-adapter. The external slider is configured to rotate about the screw gear. The T-tube and the Y-adapter collectively form a hub configured to slide linearly along the screw gear as the external slider rotates. The T-tube defines a main lumen port extending therethrough and is configured to receive the stent graft cover and a main lumen. The Y-adapter defines a secondary lumen port and is configured to receive a secondary lumen.

Abstract: A device (100) includes a leg engaging section (101) and a foot engaging section (102) intersecting at a heel receiver (103). The leg engaging section and the foot engaging section define a leg insertion aperture (104). A compressible cushion layer (402) is disposed at least in the leg engaging section. At least one bolster tube (401) is disposed interior the leg engaging section. The bolster tube (401) can be selectively removable through one or more apertures (1105,1106).

Abstract: A convex ostomy barrier for attaching an ostomy appliance to a peristomal skin surrounding a stoma includes a skin barrier formed from a skin friendly adhesive, an inlet opening for receiving a stoma, and a convex insert system arranged adjacent the skin barrier to provide a convex body-side contour of the convex ostomy barrier. The convex insert system includes a convex insert and a ring, which are configured to be assembled together to form the convex insert system.

Abstract: Embodiments disclosed herein are directed to fluid collection assemblies that include at least one inflation device, methods for using the same, and systems including the same. An example fluid collection assembly includes a fluid impermeable barrier defining at least one opening, a chamber, and at least one fluid outlet. The fluid collection assembly also includes at least one porous material disposed in the chamber. The fluid collection assembly further includes at least one inflation device. The inflation device includes at least one bladder having one or more walls defining an interior region. The inflation device also includes at least one valve configured to selectively permit flow of at least one inflation fluid into and out of the interior region to switch the at least one bladder between a first state and a second state.

Abstract: An example device suitable for collecting and transporting urine away from the body of a person may include a fluid impermeable housing defining an internal volume. The device can include a porous material disposed within the internal volume. The fluid impermeable housing can define an opening in fluid communication with the internal volume. The porous material includes a contact surface and first and second sidewalls. The sidewalls can extend from the contact surface, for example, substantially orthogonal to the contact surface, or laterally and inwardly from the contact surface at an acute angle.

Abstract: The present invention relates to a menstrual cup, the menstrual cup according to the present invention comprising: a main body having an open end and a space therein in which menstrual blood is collected; an outlet on the other end of the main body; a stopper packing for blocking the outlet; and a connection part which has one end thereof connected to the stopper packing and the other end thereof directly or indirectly connected to the main body, and which is made of an elastic material so as to move the stopper packing to the original position thereof, if the stopper packing has been spaced away from the outlet due to an external force and then the external force is removed.

Abstract: A jig assembly may include an upper jig including an upper bite block for receiving upper teeth, a lower jig including a lower bite block for receiving lower teeth, and a fastener for securing each of the upper jig and the lower jig in a fixed position relative to one another. A jig assembly may include a first jig and a second jig coupled to the first jig. The first jig and the second jig may be switchable between a first configuration in which the first jig is slidable relative to the second jig in a first direction and a second configuration in which the first jig and the second jig are fixed relative to each other in the first direction.

Abstract: Fluid delivery devices and methods are described, where the device may comprise a piezoelectric actuator operatively coupled to an ampoule with fluid, under a preloading force. The ampoule may comprise a thin-walled thermoplastic package which includes one or more apertures positioned on the wall of the ampoule. The piezoelectric actuator may be configured to clamp at least partially around the circumference of the ampoule and apply oscillations to its wall. The oscillations, typically in ultrasonic frequency, produce cycles of acoustic pressure in the fluid, leading to ejection of the fluid droplets or streams from the apertures.

Abstract: An imaging probe comprises a camera or endoscope with an external detector array, in which the probe is sized and shaped for surgical placement in an eye to image the eye from an interior of the eye during treatment. The imaging probe and a treatment probe can be coupled together with a fastener or contained within a housing. The imaging probe and the treatment probe can be sized and shaped to enter the eye through an incision in the cornea and image one or more of the ciliary body band or the scleral spur. The treatment probe may comprise a treatment optical fiber or a surgical placement device to deliver an implant. A processor coupled to the detector can be configured with instructions to identify a location of one or more of the ciliary body band, the scleral spur, Schwalbe's line, or Schlemm's canal from the image.

Abstract: Certain aspects of the present disclosure provide a probe comprising a tube, wherein one or more optical fibers extend at least partially through the tube for transmitting at least one of a laser light and an illumination light from a light source to a target location. A distal end of the tube comprises a flat-walled morphology, and a protective window with a round edge is press-fit to the distal end. The flat-walled morphology of the distal end of the tube has a reduced diametric interference sensitivity, thus allowing a wider range of tolerances between the window and the tube walls for effective press-fitting.

Abstract: The disclosure provides a system that may: determine first multiple focal point distances associated with respective multiple positions of a plane orthogonal to a laser beam; determine second multiple focal point distances associated with the respective multiple positions via for each position of the multiple positions: determine multiple intensity values associated with respective multiple interim focal point distances, each interim focal point distance greater than each focal point distance of the first multiple focal point distances associated with the position; determine an interim focal point distance respectively associated with a maximum intensity value; and determine a focal point distance as the interim focal point distance; and determine a depth of at least one incision in an eye based at least on differences between each of the second multiple focal point distances and each respective one of the first multiple focal point distances.

Abstract: A patient interface for an ophthalmic system can include an attachment portion, configured to attach the patient interface to a distal end of the ophthalmic system; a contact portion, configured to dock the patient interface to an eye; and a contact element, coupled to the contact portion, configured to contact a surface of a cornea of the eye as part of the docking of the patient interface to the eye, and having a central portion with a central radius of curvature Rc and a peripheral portion with a peripheral radius of curvature Rp, wherein Rc is smaller than Rp.

Abstract: A protective eye mask for practicing winter sports and in particular alpine skiing is provided. The protective eye mask is provided with an electrically powered lyquid crystal (LC) lens having at least one LC layer made of guest-host (GH) type liquid crystals.

Abstract: Embodiments of the present invention are related to a patient protection apparatus with a first side, a second side, a back, a top and a front visor. The first side and second side each include at least one of a side arm aperture, an instrument aperture and an air filter interface. The back includes a plurality of back arm apertures and at least one back instrument aperture. The top has a wider length at the front of the apparatus and a shorter length at the back allowing the first side and second side to taper at an angle from the front to the back. Some embodiments include wheels for easy transportation and removable front enclosures. Other embodiments include smaller dimensions for ease of transport and more versatile application.

Abstract: The invention relates to a patient positioning device (1, 6, 28, 35) for an x-ray imaging apparatus (23), comprising an x-ray-transparent patient positioning board (5) for positioning a patient (21) in a longitudinal direction (8), and at least one carrier device (3) at least partially supporting the patient positioning board (5). The patient positioning board (5) is subdivided into at least two partial boards (4), wherein each partial board (4) is mounted on a carrier device (3) assigned to the partial board (4). Each carrier device (3) has at least one pivot joint for pivoting the partial boards (4) about a transverse axis (20) which extents horizontally perpendicularly to the longitudinal direction (8).

Abstract: This disclosure describes a low-profile, high-load, and hands-free ball-balancing omnidirectional rolling system with multiple human-robot interfaces for modular and adaptive design configurations and input control interfaces. The disclosed platform uses a self-balancing ball-based robot to allow for a safe, compact, high-load, self-balancing and intuitive mobility device for a person with lower-limb disability. Advanced driving assistance such as obstacle avoidance and semi-autonomous navigation between predefined locations is also disclosed.

Abstract: A support device includes a base portion, a leg coupled to the base portion, the leg including an upper segment, a central segment pivotally coupled to the upper segment at a front wheel, a lower segment pivotally coupled to the central segment, a rear wheel coupled to the lower segment, and an engagement member coupled to the lower segment, where the engagement member is positionable between a disengaged position, in which at least a portion of the engagement member is positioned above the rear wheel, and an engaged position, in which at least a portion of the engagement member is positioned at or below the rear wheel.

Abstract: The invention relates to retention systems for retaining items during use of a mobility chair. According to one embodiment, a mobility chair includes a frame, wheels and a seat; and an item retention system including one or more retractable straps such that when, in use, a user is positioned on the seat, the one or more retractable straps are arranged to be extended and secured to retain one or more items positioned on the user's lap or on the seat in front of the user. A related method of retaining an item or items on the user's lap is also described.

Abstract: A cushion has at least one fluid chamber and at least one cushion conduit to enable fluid to be added to or removed from the at least one fluid chamber of the cushion. A management system for the cushion has a pressure sensor to measure a pressure of fluid in the at least one fluid chamber of the cushion and to transmit a sensor report with the measured pressure, a tube having a first end connecting to the cushion conduit, a second end leading to the pressure sensor, and a valve to enable fluid to be added to or removed from the at least one fluid chamber of the cushion through the cushion conduit and a processor to receive the sensor report, determine a pressure value of the at least one fluid chamber of the cushion based on the measured pressure in the sensor report, and generate a status indicative of the pressure value of the fluid chamber of the cushion.

Abstract: Systems and methods for detecting a pinch event or obstruction to a movable component of a patient support. In some embodiments, the patient support apparatus may include a control system capable of controlling one or more actuator systems coupled to one or more movable components of the patient support apparatus. The control system may operate according to one or more modes of operation in controlling the actuator system to move a component from a first position to a second position. In one embodiment, the control system may receive sensor feedback indicative of one or more operating characteristics of an actuator system, and analyze the sensor feedback differently in one mode than in another. In one embodiment, the controller may receive sensor feedback indicative of both a speed of a component coupled to the movable component and a current of power supplied to an electric motor of the actuator system.

Abstract: A patient support apparatus includes a support structure having a patient support deck and a side rail coupled to the support structure. The side rail is movable relative to the support structure. A lock releasably locks the side rail in one or more side rail positions, such as in a raised position and an intermediate position. A manual release is coupled to the side rail and operable to unlock the side rail. A bypass lever is provided to allow a user to raise the side rail from a lowered position to the raised position without locking in the intermediate position. A damper is located inside the side rail to counterbalance the weight of the side rail and assist the user in raising the side rail, bi-directionally. The side rail is formed of first and second walls that are heat staked together to form a lightweight side rail of suitable strength.

Abstract: A patient transport apparatus comprises a base, a patient support deck, a wheel assembly, and a braking system. The wheel assembly includes a wheel and a braking mechanism. The braking system includes a linkage assembly, a manual actuator, and an electrical braking assembly. The linkage assembly is arranged to place the braking mechanism in a braked state and a released state. The manual actuator moves the linkage assembly manually to place the braking mechanism in the braked state and the released state. The electrical braking assembly includes a driving assembly that moves to a first position and to a second positing that causes the linkage assembly to place the braking mechanism in the braked state and the released state. The linkage assembly is movable relative to the driving assembly to enable the braking mechanism to be manually actuated with the manual actuator.

Abstract: A patient support apparatus pneumatic system may include a mattress defining an interior and a pneumatic enclosure in fluid communication with the interior and comprising an inlet and an outlet. A blower may be in fluid communication with the interior and the pneumatic enclosure. A pressure sensor may be configured to detect a pressure at the outlet. A controller may be configured to monitor a speed of the blower and the pressure at the outlet for detecting at least one of an intake blockage condition and an exhaust blockage condition.

Abstract: The present invention relates to an electric propulsion system (1) for a rolling object, comprising a frame (2) with at least one motorized wheel (3), and at least one non-motorized wheel (4), a handlebar (6) and coupling means (5). Coupling means (5) are intended for gripping, orientation and lifting of at least one wheel of the rolling load. The means of orienting the wheel of the rolling object orient the wheel perpendicular to the longitudinal direction (x) of the frame.

Abstract: A treatment apparatus for providing spinal compensation therapy may include a base structure configured to support a patient lying in a supine position on the treatment apparatus, and an incrementally configurable adjustment assembly configured to modify the base structure between an initial configuration, an intermediate configuration, and a target configuration. The initial configuration may define spinal curves generated based on initial patient parameters associated with evaluation of the patient to define a first increment in progress toward the target configuration, and the intermediate configuration may define modified spinal curves relative to the initial configuration to define a second increment in the progress toward the target configuration.

Abstract: A massage device includes a shell, a massage member and a driving member arranged in the shell and connected to the massage member in a transmission way. The shell is configured to be inserted into a human body, and a moving space is defined in the shell and extends through a lateral wall of the shell to communicate with an outside environment out of the shell. The massage member is mounted in the moving space and rotatably connected to the shell by a pivot, and includes a plurality of massage portions arranged around the pivot. When the massage member rotates about the pivot, the plurality of massage portions of the massage member rotates to the outside environment out of the space of the shell sequentially, so as to stimulate a portion of the human body around the shell.

Abstract: Systems and processes for determining pressure settings for a percussive massage applicator are described. According to one embodiment, a method comprises obtaining an operational current measurement of the motor when the motor has a load. difference value is determined between the current measurement and the operational current measurement. The difference value is compared to two or more predetermined ranges of values that correspond to a pressure level of the percussive applicator. The pressure level may be provided as feedback to the user.

Abstract: A leg support exoskeleton is strapped on as a wearable device to support its user during squatting. The exoskeleton includes a knee joint connected to a first link and a second link, which is configured to allow flexion and extension motion between the first link and the second link. A force generator has a first end that is rotatably connected to the first link. A constraining mechanism is connected to the second link and has at least two operational positions. In a first operational position, the second end of the force generator engages the constraining mechanism, where the first link and the second link flex relative to each other. In a second operational position, the second end of the force generator does not engage the constraining mechanism; the first link and the second link are free to flex and extend relative to each other.

Abstract: An exoskeleton device that includes an artificial joint and a frame member extending from the artificial joint. The frame member is configured for extension over a limb of a user. The exoskeleton device also includes a self-aligning mechanism connected to the frame member. The self-aligning mechanism includes three passive degrees of freedom (pDOF) provided in a prismatic-revolute-revolute (PRR) configuration. The self-aligning mechanism also includes a limb attachment member configured for mechanically coupling to a portion of the limb of the user.

Abstract: There is presented a system and method for providing real-time object recognition to a remote user. The system comprises a portable communication device including a camera, at least one client-server host device remote from and accessible by the portable communication device over a network, and a recognition database accessible by the client-server host device or devices. A recognition application residing on the client-server host device or devices is capable of utilizing the recognition database to provide real-time object recognition of visual imagery captured using the portable communication device to the remote user of the portable communication device. In one embodiment, a sighted assistant shares an augmented reality panorama with a visually impaired user of the portable communication device where the panorama is constructed from sensor data from the device.

Abstract: A method, apparatus, and device for controlling a moxibustion manipulator are disclosed. The method includes: acquiring acupuncture point position information; determining coordinate information of the moxibustion manipulator based on the acupuncture point position information and safe distance information, and controlling the moxibustion manipulator to move to a position corresponding to the coordinate information; acquiring coordinate information of a light spot, and determining a plane corresponding to the light spot based on the coordinate information of the light spot; determining rotation angle information of the moxibustion manipulator based on the plane corresponding to the light spot, the rotation angle information being used to adjust an angle of the manipulator relative to the plane corresponding to the light spot; and controlling, based on the rotation angle information, the moxibustion manipulator to adjust the angle.

Abstract: A bioprocess vessel includes a flexible bag or substantially rigid container that defines an interior volume and having a bottom surface, the bottom surface being open or containing an aperture therein for the passage of fluid. A pump is secured to the bottom surface of the flexible bag or substantially rigid container. In some embodiments is secured directly to the flexible bag or substantially rigid container. In other embodiments, the pump is secured indirectly the flexible bag or substantially rigid container using, for example, a port that extends through the aperture on the bottom surface. The port or flanged surface may also be integrated into the pump, which is secured to the vessel. An optional mixing adaptor may be provided inside the interior volume of the flexible bag or substantially rigid container and at least partially covers the inlet that leads to the pump.

Abstract: Provided is packaged medicine capable of inhibiting deterioration of electrodes over a long period of time and reliably transmitting a signal after ingestion even when a long period of time has elapsed since production to ingestion. The packaged medicine includes a solid medicine including drug powder and a micro-device, a container provided with a solid medicine accommodating space accommodating the solid medicine therein, and inert gas encapsulated in the solid medicine accommodating space. The micro-device includes two electrodes with mutually different ionization tendencies and a transmitter operable to transmit a signal using electromotive force generated when the electrodes come in contact with electrolyte.

Abstract: A filling machine for filling capsules with at least one product includes operating stations for operating on the capsules, and a moving system for transferring the capsules through the operating stations that include first and second dosing stations that are configured to fill the capsules with respective products. The moving system includes a linear electric motor, a guide rail, which includes a stator of the motor, and transfer carriages associated with the guide rail and provided with respective seats to house bodies and caps of the capsules. The transfer carriages have respective rotors of the motor interacting independently with respective magnetic fields generated by the stator to move the respective transfer carriages along the guide rail with an intermittent motion at the first dosing station when the first dosing station is activated and/or with a continuous motion at the second dosing station when the second dosing station is activate.

Abstract: The present invention disclosed a full automatic medication dispensing system and methods of solid medication separation, comprising of a medication feeding device, a medication separation device, a medication distributing channel device, a medication supply device, a medication returning device and a central processing unit. The system has no requirement on the size, shape and weight of solid medications, the medications can be automatically and accurately dispensed into the sealed medication supply box according to the set parameters, and the excessive medications are automatically returned to the medication retrieving bottles. The system can remind a medication taking person to take the medication in time and supply the medications when confirmed. User can choose a portable medication box or a fixed medication box with a larger capacity.

Abstract: A breastfeeding device is disclosed comprising a nipple, a housing, and one or more adjustable straps. The nipple is removably coupled to an amorphous liquid bag via a nozzle assembly. The housing comprises a protuberant portion having a first aperture, a back portion, and one or more fasteners. The protuberant portion and the back portion are removably attached to one another and form an interior cavity. The one or more fasteners are configured to removably attach the a protuberant portion to the back portion. The nipple is insertable into the first aperture of the protuberant portion and protrudes through the first aperture while the amorphous liquid bag remains within the interior cavity. The one or more adjustable straps are attached to the back portion.

Abstract: The present disclosure relates to compositions and methods for the diagnosis and treatment or prevention of proteinopathies, particularly MUC1-associated kidney disease (ADTKD-MUC1 or MKD), Retinitis Pigmentosa (e.g., due to rhodopsin mutations), autosomal dominant tubulo-interstitial kidney disease due to UMOD mutation(s) (ADTKD-UMOD), and other forms of toxic proteinopathies resulting from mutant protein accumulation in the ER or other secretory pathway compartments and/or vesicles, among others. The disclosure also identifies and provides TMED9-binding agents as capable of treating or preventing proteinopathies of the secretory pathway, and further provides methods for identifying additional TMED9-binding agents.

Abstract: The invention relates to novel veterinary compositions comprising torasemide or a pharmaceutically acceptable salt thereof and administered in domestic animals according to a predetermined dosage for symptomatic treatment of pulmonary edema associated with heart failure.

Abstract: Disclosed is a pharmaceutical composition comprising a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent. Also disclosed is a method of treating a myelin related disorder in a subject, the method comprising administering to the subject an effective amount of a compound of Structural Formula (I) or a pharmaceutical composition comprising the compound of Structural Formula (I). The variables of Structural Formula (I) are described herein.

Abstract: The molecular mechanism of the function of TBC1D15 in NOTCH activation and stabilization is associated with maintenance and expansion of tumor-initiating stem-like cells (TICs). We herein demonstrate that TBC1D15 preferentially binds an NUMB isoform and NOTCH1-PEST domain and stabilizes NOTCH1 protein. This interaction enhances phosphorylation of NUMB, taking it away from NUMB-mediated ubiquitin degradation of NOTCH. Thus, TBC1D15 acts as a switch to augment NOTCH signaling in TICs. We also have identified inhibitors of TBC1D15 such as latanoprost acid and a salt thereof, which blocks the NOTCH-TBC1D15 interaction and selectively kills CD133-positive TICs, resulting in a reduction in the tumor size in a patient-derived, hepatocellular carcinoma xenograft model.

Abstract: A use of Gemifibrozil and a pharmaceutically acceptable salt, ester, or stereoisomer thereof in the preparation of a medicament for the treatment and/or prevention of a neurodegenerative disease. The neurodegenerative disease is selected from Alzheimer's disease, Parkinson's disease, Huntington's disease, or amyotrophic lateral sclerosis. Further provided is a pharmaceutical composition for treating and/or preventing a neurodegenerative disease, wherein the pharmaceutical composition comprises Gemifibrozil, or a pharmaceutically acceptable salt, ester, or stereoisomer thereof, and, preferably, the pharmaceutical composition further comprises one or a plurality of pharmaceutically acceptable carriers. Further provided is a use of the pharmaceutical composition comprising Gemifibrozil, or a pharmaceutically acceptable salt, ester, or stereoisomer thereof in the preparation of a medicament for the treatment and/or prevention of a neurodegenerative disease.

Abstract: A composition is provided comprising an effective amount of a combination of gamma linolenic acid (GLA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA). The composition comprises about 5% w/w to about 25% w/w GLA, and about 5% w/w to about 25% w/w of a mixture of DHA and EPA. Methods of modulating fatty acid profiles or treating an inflammatory condition in a horse include administering an effective amount of the composition to the horse. The inflammatory conditions capable of being treated include gastric ulcers, airway inflammation, joint inflammation, or combinations thereof.

Abstract: Nanoparticles comprising micheliolide (MCL) or derivatives thereof, and optionally additional therapeutic agents, such as chemotherapeutic agents, are described. Also described are methods of treating diseases, such as cancer, comprising the use of combinations of MCL or a derivative thereof with X-ray irradiation and/or other therapeutic agents, such as immune checkpoint inhibitors. The use of the combinations can provide synergistic anticancer therapeutic efficacy, for example, as the MCL or derivative thereof can both sensitize cancer cells to therapy and target resistant cancer stem cells (CSCs) for selective cell death.